format-version: 1.2 data-version: releases/2025-05-15 subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" subsetdef: blood_and_immune_upper_slim "" subsetdef: cell_quality "" subsetdef: cellxgene_subset "" subsetdef: common_anatomy "" subsetdef: cumbo "" subsetdef: developmental_classification "" subsetdef: disposition_slim "" subsetdef: early_development "" subsetdef: efo_slim "" subsetdef: emapa_ehdaa2 "" subsetdef: eye_upper_slim "" subsetdef: functional_classification "" subsetdef: general_cell_types_upper_slim "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_obsoletion_candidate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_euk_cellular_processes_ribbon "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_plant_ribbon "" subsetdef: goslim_pombe "" subsetdef: goslim_prokaryote "" subsetdef: goslim_prokaryote_ribbon "" subsetdef: goslim_synapse "" subsetdef: goslim_yeast "" subsetdef: grouping_class "" subsetdef: homology_grouping "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: human_reference_atlas "" subsetdef: human_subset "" subsetdef: inconsistent_with_fma "" subsetdef: location_grouping "" subsetdef: major_organ "" subsetdef: mouse_subset "" subsetdef: mpath_slim "" subsetdef: non_informative "" subsetdef: organ_slim "" subsetdef: pheno_slim "" subsetdef: phenotype_rcn "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: uberon_slim "" subsetdef: ubprop:upper_level "" subsetdef: unverified_taxonomic_grouping "" subsetdef: upper_level "" subsetdef: value_slim "" subsetdef: vertebrate_core "" ontology: ecao property_value: http://purl.org/dc/elements/1.1/description "None" xsd:string property_value: http://purl.org/dc/elements/1.1/title "Echinoderm Anatomy and Development Ontology" xsd:string property_value: http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/3.0/ [Term] id: BFO:0000001 name: entity property_value: BFO:0000179 "entity" xsd:string property_value: BFO:0000180 "Entity" xsd:string property_value: editor_note "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string property_value: editor_note "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", http://www.w3.org/2000/01/rdf-schema#seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"} property_value: IAO:0000112 "Julius Caesar" xsd:string property_value: IAO:0000112 "the Second World War" xsd:string property_value: IAO:0000112 "Verdi’s Requiem" xsd:string property_value: IAO:0000112 "your body mass index" xsd:string property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant property_value: BFO:0000179 "continuant" xsd:string property_value: BFO:0000180 "Continuant" xsd:string property_value: editor_note "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string property_value: editor_note "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"} property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 ! occurrent property_value: editor_note "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string property_value: editor_note "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string property_value: IAO:0000589 "processual entity (BFO)" xsd:string [Term] id: BFO:0000004 name: independent continuant def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000004 ! independent continuant property_value: BFO:0000179 "ic" xsd:string property_value: BFO:0000180 "IndependentContinuant" xsd:string property_value: IAO:0000112 "a chair" xsd:string property_value: IAO:0000112 "a heart" xsd:string property_value: IAO:0000112 "a leg" xsd:string property_value: IAO:0000112 "a molecule" xsd:string property_value: IAO:0000112 "a spatial region" xsd:string property_value: IAO:0000112 "an atom" xsd:string property_value: IAO:0000112 "an orchestra." xsd:string property_value: IAO:0000112 "an organism" xsd:string property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string property_value: IAO:0000112 "the interior of your mouth" xsd:string property_value: IAO:0000589 "anatomical entity (BFO)" xsd:string property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000006 name: spatial region is_a: BFO:0000141 ! immaterial entity property_value: editor_note "BFO 2 Reference: Spatial regions do not participate in processes." xsd:string [Term] id: BFO:0000015 name: process def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. is_a: BFO:0000003 ! occurrent property_value: editor_note "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string property_value: IAO:0000112 "a process of meiosis" xsd:string property_value: IAO:0000112 "a process of sleeping" xsd:string property_value: IAO:0000112 "the course of a disease" xsd:string property_value: IAO:0000112 "the flight of a bird" xsd:string property_value: IAO:0000112 "the life of an organism" xsd:string property_value: IAO:0000112 "your process of aging." xsd:string [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role [Term] id: BFO:0000017 name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 ! realizable entity property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string property_value: IAO:0000112 "the function of your reproductive organs" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string property_value: IAO:0000112 "the color of a tomato" xsd:string property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string property_value: IAO:0000112 "the mass of this piece of gold." xsd:string property_value: IAO:0000112 "the shape of your nose" xsd:string property_value: IAO:0000112 "the shape of your nostril" xsd:string [Term] id: BFO:0000020 name: specifically dependent continuant def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000020 ! specifically dependent continuant property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the shape of this hole." xsd:string property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string [Term] id: BFO:0000023 name: role def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] is_a: BFO:0000017 ! realizable entity property_value: editor_note "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives." xsd:string property_value: IAO:0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string property_value: IAO:0000112 "the priest role" xsd:string property_value: IAO:0000112 "the role of a boundary to demarcate two neighboring administrative territories" xsd:string property_value: IAO:0000112 "the role of a building in serving as a military target" xsd:string property_value: IAO:0000112 "the role of a stone in marking a property boundary" xsd:string property_value: IAO:0000112 "the role of subject in a clinical trial" xsd:string property_value: IAO:0000112 "the student role" xsd:string [Term] id: BFO:0000034 name: function is_a: BFO:0000016 ! disposition [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity property_value: BFO:0000179 "material" xsd:string property_value: BFO:0000180 "MaterialEntity" xsd:string property_value: editor_note "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string property_value: editor_note "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string property_value: editor_note "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string property_value: editor_note "Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." xsd:string property_value: IAO:0000112 "a flame" xsd:string property_value: IAO:0000112 "a forest fire" xsd:string property_value: IAO:0000112 "a human being" xsd:string property_value: IAO:0000112 "a hurricane" xsd:string property_value: IAO:0000112 "a photon" xsd:string property_value: IAO:0000112 "a puff of smoke" xsd:string property_value: IAO:0000112 "a sea wave" xsd:string property_value: IAO:0000112 "a tornado" xsd:string property_value: IAO:0000112 "an aggregate of human beings." xsd:string property_value: IAO:0000112 "an energy wave" xsd:string property_value: IAO:0000112 "an epidemic" xsd:string property_value: IAO:0000112 "the undetached arm of a human being" xsd:string property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant property_value: editor_note "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10" xsd:string [Term] id: CARO:0000000 name: anatomical entity namespace: spatial def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH] [Term] id: CHEBI:10545 name: electron namespace: chebi_ontology def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." [] subset: 3_STAR synonym: "beta" RELATED [IUPAC] synonym: "beta(-)" RELATED [ChEBI] synonym: "beta-particle" RELATED [IUPAC] synonym: "e" RELATED [IUPAC] synonym: "e(-)" RELATED [UniProt] synonym: "e-" RELATED [KEGG_COMPOUND] synonym: "electron" EXACT [KEGG_COMPOUND] synonym: "electron" EXACT IUPAC_NAME [IUPAC] synonym: "electron" EXACT [ChEBI] synonym: "Elektron" RELATED [ChEBI] synonym: "negatron" RELATED [IUPAC] xref: KEGG:C05359 xref: PMID:21614077 {source="Europe PMC"} xref: Wikipedia:Electron is_a: CHEBI:36338 ! lepton [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives namespace: chebi_ontology def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." [] subset: 3_STAR synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI] is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:132153 name: hyaluronate namespace: chebi_ontology def: "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "hyaluronan" RELATED [UniProt] synonym: "hyaluronate polyanion" RELATED [ChEBI] is_a: CHEBI:61469 ! polyanionic polymer is_a: CHEBI:63551 ! carbohydrate acid derivative anion relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid [Term] id: CHEBI:136889 name: 5beta steroid namespace: chebi_ontology def: "Any steroid that has beta-configuration at position 5." [] subset: 3_STAR synonym: "5beta steroids" RELATED [ChEBI] synonym: "5beta-steroid" RELATED [ChEBI] synonym: "5beta-steroids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:138103 name: inorganic acid namespace: chebi_ontology def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." [] subset: 3_STAR synonym: "inorganic acids" RELATED [ChEBI] synonym: "mineral acid" RELATED [ChEBI] synonym: "mineral acids" RELATED [ChEBI] xref: Wikipedia:Mineral_acid is_a: CHEBI:39141 ! Bronsted acid [Term] id: CHEBI:138366 name: bile acids namespace: chebi_ontology def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." [] subset: 3_STAR is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:35350 ! hydroxy steroid is_a: CHEBI:36078 ! cholanoid [Term] id: CHEBI:138675 name: gas molecular entity namespace: chebi_ontology def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." [] subset: 3_STAR synonym: "gas molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entity" RELATED [ChEBI] xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:13941 name: carbamate namespace: chebi_ontology subset: 3_STAR synonym: "Carbamat" RELATED [ChEBI] synonym: "carbamate" EXACT [UniProt] synonym: "carbamate" EXACT IUPAC_NAME [IUPAC] synonym: "carbamate ion" RELATED [ChemIDplus] synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Karbamat" RELATED [ChEBI] xref: Beilstein:3903503 {source="Beilstein"} xref: CAS:302-11-4 {source="ChemIDplus"} xref: Gmelin:239604 {source="Gmelin"} is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid [Term] id: CHEBI:142163 name: 24G7 epitope namespace: chebi_ontology def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." [] subset: 3_STAR is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24433 ! group relationship: RO:0000087 CHEBI:53000 ! has role epitope [Term] id: CHEBI:15339 name: acceptor namespace: chebi_ontology alt_id: CHEBI:13699 alt_id: CHEBI:2377 def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." [] subset: 3_STAR synonym: "A" RELATED [KEGG_COMPOUND] synonym: "accepteur" RELATED [ChEBI] synonym: "Acceptor" EXACT [KEGG_COMPOUND] synonym: "Akzeptor" RELATED [ChEBI] synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND] synonym: "Oxidized donor" RELATED [KEGG_COMPOUND] xref: KEGG:C00028 xref: KEGG:C16722 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:15355 name: acetylcholine namespace: chebi_ontology alt_id: CHEBI:12686 alt_id: CHEBI:13715 alt_id: CHEBI:22197 alt_id: CHEBI:2416 alt_id: CHEBI:40559 def: "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." [] subset: 3_STAR synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "ACETYLCHOLINE" EXACT [PDBeChem] synonym: "Acetylcholine" EXACT [KEGG_COMPOUND] synonym: "acetylcholine" EXACT [UniProt] synonym: "ACh" RELATED [ChemIDplus] synonym: "Azetylcholin" RELATED [ChEBI] synonym: "choline acetate" RELATED [ChemIDplus] synonym: "O-Acetylcholine" RELATED [KEGG_COMPOUND] xref: Beilstein:1764436 {source="ChemIDplus"} xref: CAS:51-84-3 {source="KEGG COMPOUND"} xref: CAS:51-84-3 {source="ChemIDplus"} xref: Drug_Central:65 {source="DrugCentral"} xref: DrugBank:DB03128 xref: Gmelin:326108 {source="Gmelin"} xref: KEGG:C01996 xref: LINCS:LSM-5888 xref: PDBeChem:ACH xref: PMID:14764638 {source="Europe PMC"} xref: PMID:15014918 {source="Europe PMC"} xref: PMID:15231705 {source="Europe PMC"} xref: PMID:15361288 {source="Europe PMC"} xref: PMID:18050502 {source="Europe PMC"} xref: PMID:18407448 {source="Europe PMC"} xref: PMID:19255787 {source="Europe PMC"} xref: PMID:20963497 {source="Europe PMC"} xref: PMID:21130809 {source="Europe PMC"} xref: PMID:21246223 {source="Europe PMC"} xref: PMID:21545631 {source="Europe PMC"} xref: PMID:21601579 {source="Europe PMC"} xref: Wikipedia:Acetylcholine is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35287 ! acylcholine is_a: CHEBI:47622 ! acetate ester relationship: RO:0000087 CHEBI:24621 ! has role hormone relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:38325 ! has role muscarinic agonist relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:15366 name: acetic acid namespace: chebi_ontology alt_id: CHEBI:22169 alt_id: CHEBI:2387 alt_id: CHEBI:40486 def: "A simple monocarboxylic acid containing two carbons." [] subset: 3_STAR synonym: "ACETIC ACID" EXACT [PDBeChem] synonym: "Acetic acid" EXACT [KEGG_COMPOUND] synonym: "acetic acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide acetique" RELATED [ChemIDplus] synonym: "AcOH" RELATED [ChEBI] synonym: "CH3-COOH" RELATED [IUPAC] synonym: "CH3CO2H" RELATED [ChEBI] synonym: "E 260" RELATED [ChEBI] synonym: "E-260" RELATED [ChEBI] synonym: "E260" RELATED [ChEBI] synonym: "Essigsaeure" RELATED [ChEBI] synonym: "Ethanoic acid" RELATED [KEGG_COMPOUND] synonym: "ethoic acid" RELATED [ChEBI] synonym: "Ethylic acid" RELATED [ChemIDplus] synonym: "HOAc" RELATED [ChEBI] synonym: "INS No. 260" RELATED [ChEBI] synonym: "MeCO2H" RELATED [ChEBI] synonym: "MeCOOH" RELATED [ChEBI] synonym: "Methanecarboxylic acid" RELATED [ChemIDplus] xref: CAS:64-19-7 {source="ChemIDplus"} xref: CAS:64-19-7 {source="NIST Chemistry WebBook"} xref: CAS:64-19-7 {source="KEGG COMPOUND"} xref: Drug_Central:4211 {source="DrugCentral"} xref: Gmelin:1380 {source="Gmelin"} xref: HMDB:HMDB0000042 xref: KEGG:C00033 xref: KEGG:D00010 xref: KNApSAcK:C00001176 xref: LIPID_MAPS_instance:LMFA01010002 {source="LIPID MAPS"} xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PDBeChem:ACY xref: PMID:12005138 {source="Europe PMC"} xref: PMID:15107950 {source="Europe PMC"} xref: PMID:16630552 {source="Europe PMC"} xref: PMID:16774200 {source="Europe PMC"} xref: PMID:17190852 {source="Europe PMC"} xref: PMID:19416101 {source="Europe PMC"} xref: PMID:19469536 {source="Europe PMC"} xref: PMID:22153255 {source="Europe PMC"} xref: PMID:22173419 {source="Europe PMC"} xref: PPDB:1333 xref: Reaxys:506007 {source="Reaxys"} xref: Wikipedia:Acetic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:30089 ! acetate relationship: RO:0000087 CHEBI:48356 ! has role protic solvent relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:15379 name: dioxygen namespace: chebi_ontology alt_id: CHEBI:10745 alt_id: CHEBI:13416 alt_id: CHEBI:23833 alt_id: CHEBI:25366 alt_id: CHEBI:30491 alt_id: CHEBI:44742 alt_id: CHEBI:7860 subset: 3_STAR synonym: "[OO]" RELATED [MolBase] synonym: "dioxygen" EXACT IUPAC_NAME [IUPAC] synonym: "dioxygene" RELATED [ChEBI] synonym: "Disauerstoff" RELATED [ChEBI] synonym: "E 948" RELATED [ChEBI] synonym: "E-948" RELATED [ChEBI] synonym: "E948" RELATED [ChEBI] synonym: "molecular oxygen" RELATED [ChEBI] synonym: "O2" RELATED [UniProt] synonym: "O2" RELATED [IUPAC] synonym: "O2" RELATED [KEGG_COMPOUND] synonym: "Oxygen" RELATED [KEGG_COMPOUND] synonym: "OXYGEN MOLECULE" RELATED [PDBeChem] xref: CAS:7782-44-7 {source="NIST Chemistry WebBook"} xref: CAS:7782-44-7 {source="ChemIDplus"} xref: CAS:7782-44-7 {source="KEGG COMPOUND"} xref: Gmelin:485 {source="Gmelin"} xref: HMDB:HMDB0001377 xref: KEGG:C00007 xref: KEGG:D00003 xref: MetaCyc:OXYGEN-MOLECULE xref: MolBase:750 xref: PDBeChem:OXY xref: PMID:10906528 {source="Europe PMC"} xref: PMID:16977326 {source="Europe PMC"} xref: PMID:18210929 {source="Europe PMC"} xref: PMID:18638417 {source="Europe PMC"} xref: PMID:19840863 {source="Europe PMC"} xref: PMID:7710549 {source="Europe PMC"} xref: PMID:9463773 {source="Europe PMC"} xref: Wikipedia:Oxygen is_a: BFO:0000004 ! independent continuant is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:25362 ! elemental molecule is_a: CHEBI:33263 ! diatomic oxygen relationship: is_conjugate_base_of CHEBI:29793 ! hydridodioxygen(1+) relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:33893 ! has role reagent relationship: RO:0000087 CHEBI:35472 ! has role anti-inflammatory drug relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas [Term] id: CHEBI:15693 name: aldose namespace: chebi_ontology alt_id: CHEBI:13755 alt_id: CHEBI:22305 alt_id: CHEBI:2561 def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." [] subset: 3_STAR synonym: "Aldose" EXACT [KEGG_COMPOUND] synonym: "aldoses" RELATED [ChEBI] synonym: "an aldose" RELATED [UniProt] xref: KEGG:C01370 xref: Wikipedia:Aldose is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:15841 name: polypeptide namespace: chebi_ontology alt_id: CHEBI:14860 alt_id: CHEBI:8314 def: "A peptide containing ten or more amino acid residues." [] subset: 3_STAR synonym: "polipeptido" RELATED [ChEBI] synonym: "Polypeptid" RELATED [ChEBI] synonym: "Polypeptide" EXACT [KEGG_COMPOUND] synonym: "polypeptides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00403 is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:15986 name: polynucleotide namespace: chebi_ontology alt_id: CHEBI:13672 alt_id: CHEBI:14859 alt_id: CHEBI:8312 def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." [] subset: 3_STAR synonym: "Polynucleotide" EXACT [KEGG_COMPOUND] synonym: "polynucleotides" RELATED [ChEBI] xref: KEGG:C00419 is_a: CHEBI:33695 ! information biomacromolecule is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_part CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:16134 name: ammonia namespace: chebi_ontology alt_id: CHEBI:13405 alt_id: CHEBI:13406 alt_id: CHEBI:13407 alt_id: CHEBI:13771 alt_id: CHEBI:22533 alt_id: CHEBI:44269 alt_id: CHEBI:44284 alt_id: CHEBI:44404 alt_id: CHEBI:7434 def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." [] subset: 3_STAR synonym: "[NH3]" RELATED [MolBase] synonym: "AMMONIA" EXACT [PDBeChem] synonym: "Ammonia" EXACT [KEGG_COMPOUND] synonym: "ammonia" EXACT IUPAC_NAME [IUPAC] synonym: "ammoniac" RELATED [ChEBI] synonym: "Ammoniak" RELATED [ChemIDplus] synonym: "amoniaco" RELATED [ChEBI] synonym: "azane" EXACT IUPAC_NAME [IUPAC] synonym: "NH3" RELATED [KEGG_COMPOUND] synonym: "NH3" RELATED [IUPAC] synonym: "R-717" RELATED [ChEBI] synonym: "spirit of hartshorn" RELATED [ChemIDplus] xref: CAS:7664-41-7 {source="ChemIDplus"} xref: CAS:7664-41-7 {source="NIST Chemistry WebBook"} xref: CAS:7664-41-7 {source="KEGG COMPOUND"} xref: Drug_Central:4625 {source="DrugCentral"} xref: Gmelin:79 {source="Gmelin"} xref: HMDB:HMDB0000051 xref: KEGG:C00014 xref: KEGG:D02916 xref: KNApSAcK:C00007267 xref: MetaCyc:AMMONIA xref: MolBase:930 xref: PDBeChem:NH3 xref: PMID:110589 {source="Europe PMC"} xref: PMID:11139349 {source="Europe PMC"} xref: PMID:11540049 {source="Europe PMC"} xref: PMID:11746427 {source="Europe PMC"} xref: PMID:11783653 {source="Europe PMC"} xref: PMID:13753780 {source="Europe PMC"} xref: PMID:14663195 {source="Europe PMC"} xref: PMID:15092448 {source="Europe PMC"} xref: PMID:15094021 {source="Europe PMC"} xref: PMID:15554424 {source="Europe PMC"} xref: PMID:15969015 {source="Europe PMC"} xref: PMID:16008360 {source="Europe PMC"} xref: PMID:16050680 {source="Europe PMC"} xref: PMID:16348008 {source="Europe PMC"} xref: PMID:16349403 {source="Europe PMC"} xref: PMID:16614889 {source="Europe PMC"} xref: PMID:16664306 {source="Europe PMC"} xref: PMID:16842901 {source="Europe PMC"} xref: PMID:17025297 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17569513 {source="Europe PMC"} xref: PMID:17737668 {source="Europe PMC"} xref: PMID:18670398 {source="Europe PMC"} xref: PMID:22002069 {source="Europe PMC"} xref: PMID:22081570 {source="Europe PMC"} xref: PMID:22088435 {source="Europe PMC"} xref: PMID:22100291 {source="Europe PMC"} xref: PMID:22130175 {source="Europe PMC"} xref: PMID:22150211 {source="Europe PMC"} xref: PMID:22240068 {source="Europe PMC"} xref: PMID:22290316 {source="Europe PMC"} xref: PMID:22342082 {source="Europe PMC"} xref: PMID:22385337 {source="Europe PMC"} xref: PMID:22443779 {source="Europe PMC"} xref: PMID:22560242 {source="Europe PMC"} xref: Reaxys:3587154 {source="Reaxys"} xref: Wikipedia:Ammonia is_a: BFO:0000004 ! independent continuant is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:35107 ! azane is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:29337 ! azanide relationship: is_conjugate_base_of CHEBI:28938 ! ammonium relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor relationship: RO:0000087 CHEBI:78433 ! has role refrigerant [Term] id: CHEBI:16189 name: sulfate namespace: chebi_ontology alt_id: CHEBI:15135 alt_id: CHEBI:45687 alt_id: CHEBI:9335 def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." [] subset: 3_STAR synonym: "[SO4](2-)" RELATED [IUPAC] synonym: "SO4(2-)" RELATED [IUPAC] synonym: "Sulfate" EXACT [KEGG_COMPOUND] synonym: "sulfate" EXACT [UniProt] synonym: "sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfate anion(2-)" RELATED [HMDB] synonym: "Sulfate dianion" RELATED [HMDB] synonym: "SULFATE ION" RELATED [PDBeChem] synonym: "Sulfate(2-)" RELATED [HMDB] synonym: "Sulfuric acid ion(2-)" RELATED [HMDB] synonym: "sulphate" RELATED [ChEBI] synonym: "sulphate ion" RELATED [ChEBI] synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] xref: CAS:14808-79-8 {source="ChemIDplus"} xref: CAS:14808-79-8 {source="NIST Chemistry WebBook"} xref: Gmelin:2120 {source="Gmelin"} xref: HMDB:HMDB0001448 xref: KEGG:C00059 xref: KEGG:D05963 xref: MetaCyc:SULFATE xref: PDBeChem:SO4 xref: PMID:11200094 {source="Europe PMC"} xref: PMID:11452993 {source="Europe PMC"} xref: PMID:11581495 {source="Europe PMC"} xref: PMID:11798107 {source="Europe PMC"} xref: PMID:12166931 {source="Europe PMC"} xref: PMID:12668033 {source="Europe PMC"} xref: PMID:14597181 {source="Europe PMC"} xref: PMID:15093386 {source="Europe PMC"} xref: PMID:15984785 {source="Europe PMC"} xref: PMID:16186560 {source="Europe PMC"} xref: PMID:16345535 {source="Europe PMC"} xref: PMID:16347366 {source="Europe PMC"} xref: PMID:16348007 {source="Europe PMC"} xref: PMID:16483812 {source="Europe PMC"} xref: PMID:16534979 {source="Europe PMC"} xref: PMID:16656509 {source="Europe PMC"} xref: PMID:16742508 {source="Europe PMC"} xref: PMID:16742518 {source="Europe PMC"} xref: PMID:17120760 {source="Europe PMC"} xref: PMID:17420092 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17709180 {source="Europe PMC"} xref: PMID:18398178 {source="Europe PMC"} xref: PMID:18815700 {source="Europe PMC"} xref: PMID:18846414 {source="Europe PMC"} xref: PMID:19047345 {source="Europe PMC"} xref: PMID:19244483 {source="Europe PMC"} xref: PMID:19544990 {source="Europe PMC"} xref: PMID:19628332 {source="Europe PMC"} xref: PMID:19812358 {source="Europe PMC"} xref: PMID:30398859 {source="Europe PMC"} xref: Reaxys:3648446 {source="Reaxys"} xref: Wikipedia:Sulfate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:16336 name: hyaluronic acid namespace: chebi_ontology alt_id: CHEBI:14412 alt_id: CHEBI:24622 alt_id: CHEBI:24623 alt_id: CHEBI:5772 def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." [] subset: 3_STAR synonym: "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n" RELATED [ChEBI] synonym: "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n" RELATED [KEGG_COMPOUND] synonym: "acide hyaluronique" RELATED [ChEBI] synonym: "acido hialuronico" RELATED [ChEBI] synonym: "hyaluronan" RELATED [ChEBI] synonym: "Hyaluronic acid" EXACT [KEGG_COMPOUND] synonym: "Hyaluronsaeure" RELATED [ChEBI] xref: Beilstein:8538277 {source="Beilstein"} xref: CAS:9004-61-9 {source="KEGG COMPOUND"} xref: CAS:9004-61-9 {source="ChemIDplus"} xref: HMDB:HMDB0010366 xref: KEGG:C00518 xref: KEGG:D08043 xref: KEGG:G10505 xref: PMID:11122186 {source="Europe PMC"} xref: PMID:18056362 {source="Europe PMC"} xref: PMID:18290544 {source="Europe PMC"} xref: Reaxys:8187837 {source="Reaxys"} xref: Wikipedia:Hyaluronan is_a: BFO:0000004 ! independent continuant is_a: CHEBI:37395 ! mucopolysaccharide is_a: CHEBI:72813 ! exopolysaccharide relationship: is_conjugate_acid_of CHEBI:132153 ! hyaluronate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:16541 name: protein polypeptide chain namespace: chebi_ontology alt_id: CHEBI:8526 def: "A naturally occurring polypeptide synthesized at the ribosome." [] subset: 3_STAR synonym: "a protein" RELATED [UniProt] synonym: "polypeptide chain" RELATED [ChEBI] synonym: "Protein" RELATED [KEGG_COMPOUND] synonym: "protein polypeptide chains" RELATED [ChEBI] xref: KEGG:C00017 is_a: CHEBI:15841 ! polypeptide relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue [Term] id: CHEBI:16646 name: carbohydrate namespace: chebi_ontology alt_id: CHEBI:15131 alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] subset: 3_STAR synonym: "a carbohydrate" RELATED [UniProt] synonym: "carbohidrato" RELATED [IUPAC] synonym: "carbohidratos" RELATED [IUPAC] synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC] synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC] synonym: "glucide" RELATED [ChEBI] synonym: "glucides" RELATED [ChEBI] synonym: "glucido" RELATED [ChEBI] synonym: "glucidos" RELATED [ChEBI] synonym: "hydrates de carbone" RELATED [ChEBI] synonym: "Kohlenhydrat" RELATED [ChEBI] synonym: "Kohlenhydrate" RELATED [ChEBI] synonym: "saccharide" RELATED [IUPAC] synonym: "saccharides" RELATED [IUPAC] synonym: "saccharidum" RELATED [ChEBI] xref: Wikipedia:Carbohydrate is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16670 name: peptide namespace: chebi_ontology alt_id: CHEBI:14753 alt_id: CHEBI:25906 alt_id: CHEBI:7990 def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." [] subset: 3_STAR synonym: "Peptid" RELATED [ChEBI] synonym: "Peptide" EXACT [KEGG_COMPOUND] synonym: "peptides" EXACT IUPAC_NAME [IUPAC] synonym: "peptido" RELATED [ChEBI] synonym: "peptidos" RELATED [ChEBI] xref: KEGG:C00012 is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound relationship: has_part CHEBI:33708 ! amino-acid residue relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion [Term] id: CHEBI:166902 name: noradrenaline(1+) namespace: chebi_ontology subset: 2_STAR synonym: "noradrenaline" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:33569 ! noradrenaline [Term] id: CHEBI:167559 name: glycan namespace: chebi_ontology def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." [] subset: 3_STAR synonym: "glycans" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16765 name: tryptamine namespace: chebi_ontology alt_id: CHEBI:15274 alt_id: CHEBI:27161 alt_id: CHEBI:46157 alt_id: CHEBI:9767 def: "An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position." [] subset: 3_STAR synonym: "1H-indole-3-ethanamine" RELATED [NIST_Chemistry_WebBook] synonym: "2-(1H-INDOL-3-YL)ETHANAMINE" RELATED [PDBeChem] synonym: "2-(1H-indol-3-yl)ethanamine" EXACT IUPAC_NAME [IUPAC] synonym: "2-(3-indolyl)ethylamine" RELATED [ChemIDplus] synonym: "3-(2-Aminoethyl)indole" RELATED [KEGG_COMPOUND] synonym: "Tryptamine" EXACT [KEGG_COMPOUND] xref: CAS:61-54-1 {source="ChemIDplus"} xref: CAS:61-54-1 {source="NIST Chemistry WebBook"} xref: CAS:61-54-1 {source="KEGG COMPOUND"} xref: DrugBank:DB08653 xref: Gmelin:603448 {source="Gmelin"} xref: HMDB:HMDB0000303 xref: KEGG:C00398 xref: KNApSAcK:C00001434 xref: MetaCyc:TRYPTAMINE xref: PDBeChem:TSS xref: PMID:16126914 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:24345948 {source="Europe PMC"} xref: PMID:24558969 {source="Europe PMC"} xref: Reaxys:125513 {source="Reaxys"} xref: Wikipedia:Tryptamine is_a: CHEBI:27162 ! tryptamines is_a: CHEBI:38631 ! aminoalkylindole is_a: CHEBI:38958 ! indole alkaloid is_a: CHEBI:64365 ! aralkylamino compound relationship: is_conjugate_base_of CHEBI:57887 ! tryptaminium relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:16990 name: bilirubin IXalpha namespace: chebi_ontology alt_id: CHEBI:13898 alt_id: CHEBI:22870 alt_id: CHEBI:3099 def: "A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." [] subset: 3_STAR synonym: "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid" RELATED [ChemIDplus] synonym: "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" RELATED [ChemIDplus] synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" RELATED [IUPAC] synonym: "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione" RELATED [JCBN] synonym: "Bilirubin" RELATED [KEGG_COMPOUND] synonym: "bilirubin" EXACT IUPAC_NAME [IUPAC] synonym: "bilirubin(Z,Z)" RELATED [ChEBI] synonym: "bilirubin-IXalpha" RELATED [ChEBI] xref: CAS:635-65-4 {source="KEGG COMPOUND"} xref: CAS:635-65-4 {source="ChemIDplus"} xref: Gmelin:411033 {source="Gmelin"} xref: HMDB:HMDB0000054 xref: KEGG:C00486 xref: KNApSAcK:C00029828 xref: MetaCyc:BILIRUBIN xref: PDBeChem:BLR xref: PMID:12799017 {source="Europe PMC"} xref: PMID:18442622 {source="Europe PMC"} xref: PMID:23763371 {source="Europe PMC"} xref: PMID:23768684 {source="Europe PMC"} xref: PMID:30224965 {source="Europe PMC"} xref: PMID:8605219 {source="Europe PMC"} xref: PMID:9587403 {source="Europe PMC"} xref: Reaxys:74376 {source="Reaxys"} xref: Wikipedia:Bilirubin is_a: CHEBI:35692 ! dicarboxylic acid is_a: CHEBI:36735 ! biladienes relationship: has_part CHEBI:142163 ! 24G7 epitope relationship: is_conjugate_acid_of CHEBI:57977 ! bilirubin(2-) relationship: RO:0000087 CHEBI:22586 ! has role antioxidant relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17087 name: ketone namespace: chebi_ontology alt_id: CHEBI:13427 alt_id: CHEBI:13646 alt_id: CHEBI:24974 alt_id: CHEBI:6127 alt_id: CHEBI:8742 def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." [] subset: 3_STAR synonym: "a ketone" RELATED [UniProt] synonym: "cetone" RELATED [ChEBI] synonym: "Keton" RELATED [ChEBI] synonym: "Ketone" EXACT [KEGG_COMPOUND] synonym: "ketones" EXACT IUPAC_NAME [IUPAC] synonym: "ketones" RELATED [ChEBI] synonym: "R-CO-R'" RELATED [KEGG_COMPOUND] xref: KEGG:C01450 xref: Wikipedia:Ketone is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:17089 name: glycoprotein namespace: chebi_ontology alt_id: CHEBI:14349 alt_id: CHEBI:5481 alt_id: CHEBI:5493 def: "A compound in which a carbohydrate component is covalently bound to a protein component." [] subset: 3_STAR synonym: "a glycoprotein" RELATED [UniProt] synonym: "glicoproteina" RELATED [ChEBI] synonym: "glicoproteinas" RELATED [ChEBI] synonym: "Glycoprotein" EXACT [KEGG_COMPOUND] synonym: "glycoproteine" RELATED [ChEBI] synonym: "glycoproteines" RELATED [ChEBI] synonym: "glycoproteins" EXACT IUPAC_NAME [IUPAC] synonym: "Glykoprotein" RELATED [ChEBI] synonym: "Glykoproteine" RELATED [ChEBI] xref: KEGG:C00326 is_a: CHEBI:33837 ! conjugated protein is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:17234 name: glucose namespace: chebi_ontology alt_id: CHEBI:14313 alt_id: CHEBI:24277 alt_id: CHEBI:33929 alt_id: CHEBI:5418 def: "An aldohexose used as a source of energy and metabolic intermediate." [] subset: 3_STAR synonym: "DL-glucose" RELATED [ChEBI] synonym: "Glc" RELATED [JCBN] synonym: "gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "Glucose" EXACT [KEGG_COMPOUND] synonym: "glucose" EXACT IUPAC_NAME [IUPAC] synonym: "Glukose" RELATED [ChEBI] xref: CAS:50-99-7 {source="KEGG COMPOUND"} xref: KEGG:C00293 xref: Wikipedia:Glucose is_a: BFO:0000004 ! independent continuant is_a: CHEBI:33917 ! aldohexose relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:17544 name: hydrogencarbonate namespace: chebi_ontology alt_id: CHEBI:13363 alt_id: CHEBI:22863 alt_id: CHEBI:40961 alt_id: CHEBI:5589 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." [] subset: 3_STAR synonym: "[CO2(OH)](-)" RELATED [IUPAC] synonym: "Acid carbonate" RELATED [KEGG_COMPOUND] synonym: "Bicarbonate" RELATED [KEGG_COMPOUND] synonym: "BICARBONATE ION" RELATED [PDBeChem] synonym: "HCO3(-)" RELATED [IUPAC] synonym: "HCO3-" RELATED [KEGG_COMPOUND] synonym: "hydrogen carbonate" RELATED [PDBeChem] synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND] synonym: "hydrogencarbonate" EXACT [UniProt] synonym: "hydrogencarbonate" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogencarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3903504 {source="Beilstein"} xref: CAS:71-52-3 {source="ChemIDplus"} xref: Gmelin:49249 {source="Gmelin"} xref: HMDB:HMDB0000595 xref: KEGG:C00288 xref: MetaCyc:HCO3 xref: PDBeChem:BCT xref: PMID:17215880 {source="Europe PMC"} xref: PMID:17505962 {source="Europe PMC"} xref: PMID:18439416 {source="Europe PMC"} xref: PMID:28732801 {source="Europe PMC"} xref: PMID:29150416 {source="Europe PMC"} xref: PMID:29460248 {source="Europe PMC"} xref: PMID:29466234 {source="Europe PMC"} xref: PMID:4208463 {source="Europe PMC"} xref: Wikipedia:Bicarbonate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17608 name: D-aldohexose namespace: chebi_ontology alt_id: CHEBI:12990 alt_id: CHEBI:21038 def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] subset: 3_STAR synonym: "D-aldohexoses" RELATED [ChEBI] is_a: CHEBI:33917 ! aldohexose is_a: CHEBI:4194 ! D-hexose [Term] id: CHEBI:17634 name: D-glucose namespace: chebi_ontology alt_id: CHEBI:12965 alt_id: CHEBI:20999 def: "A glucose with D-configuration." [] subset: 3_STAR synonym: "D(+)-glucose" RELATED [ChemIDplus] synonym: "D-(+)-glucose" RELATED [NIST_Chemistry_WebBook] synonym: "D-gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "D-glucose" EXACT IUPAC_NAME [IUPAC] synonym: "dextrose" RELATED [NIST_Chemistry_WebBook] synonym: "grape sugar" RELATED [ChemIDplus] synonym: "Traubenzucker" RELATED [ChemIDplus] xref: CAS:50-99-7 {source="NIST Chemistry WebBook"} xref: CAS:50-99-7 {source="ChemIDplus"} is_a: CHEBI:17234 ! glucose is_a: CHEBI:17608 ! D-aldohexose [Term] id: CHEBI:17891 name: donor namespace: chebi_ontology alt_id: CHEBI:14202 alt_id: CHEBI:4697 def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." [] subset: 3_STAR synonym: "Donator" RELATED [ChEBI] synonym: "donneur" RELATED [ChEBI] synonym: "Donor" EXACT [KEGG_COMPOUND] xref: KEGG:C01351 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:18059 name: lipid namespace: chebi_ontology alt_id: CHEBI:14517 alt_id: CHEBI:25054 alt_id: CHEBI:6486 def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [] subset: 3_STAR synonym: "Lipid" EXACT [KEGG_COMPOUND] synonym: "lipids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C01356 is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:18085 name: glycosaminoglycan namespace: chebi_ontology alt_id: CHEBI:14361 alt_id: CHEBI:24398 alt_id: CHEBI:5495 def: "Any polysaccharide containing a substantial proportion of aminomonosaccharide residues." [] subset: 3_STAR synonym: "glicosaminoglicano" RELATED [IUPAC] synonym: "Glycosaminoglycan" EXACT [KEGG_COMPOUND] synonym: "glycosaminoglycan" EXACT IUPAC_NAME [IUPAC] synonym: "glycosaminoglycane" RELATED [IUPAC] synonym: "glycosaminoglycans" RELATED [ChEBI] synonym: "Glykosaminoglykan" RELATED [ChEBI] xref: KEGG:C02545 xref: Wikipedia:Glycosaminoglycan is_a: CHEBI:22506 ! aminoglycan [Term] id: CHEBI:18133 name: hexose namespace: chebi_ontology alt_id: CHEBI:14399 alt_id: CHEBI:24590 alt_id: CHEBI:5709 def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." [] subset: 3_STAR synonym: "Hexose" EXACT [KEGG_COMPOUND] synonym: "hexoses" RELATED [ChEBI] synonym: "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" RELATED [GlyTouCan] xref: GlyGen:G70994MS xref: GlyTouCan:G70994MS xref: KEGG:C00738 is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:18154 name: polysaccharide namespace: chebi_ontology alt_id: CHEBI:14864 alt_id: CHEBI:26205 alt_id: CHEBI:8322 def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." [] subset: 3_STAR synonym: "Glycan" RELATED [KEGG_COMPOUND] synonym: "Glycane" RELATED [ChEBI] synonym: "glycans" RELATED [IUPAC] synonym: "Glykan" RELATED [ChEBI] synonym: "Glykane" RELATED [ChEBI] synonym: "polisacarido" RELATED [ChEBI] synonym: "polisacaridos" RELATED [IUPAC] synonym: "Polysaccharide" EXACT [KEGG_COMPOUND] synonym: "polysaccharides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00420 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:18282 name: nucleobase namespace: chebi_ontology alt_id: CHEBI:13873 alt_id: CHEBI:25598 alt_id: CHEBI:2995 def: "That part of DNA or RNA that may be involved in pairing." [] subset: 3_STAR synonym: "Base" RELATED [KEGG_COMPOUND] synonym: "nucleobases" RELATED [ChEBI] xref: KEGG:C00701 xref: Wikipedia:Nucleobase is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:18357 name: (R)-noradrenaline namespace: chebi_ontology alt_id: CHEBI:1 alt_id: CHEBI:14668 alt_id: CHEBI:25592 alt_id: CHEBI:258884 alt_id: CHEBI:43725 def: "The R-enantiomer of noradrenaline." [] subset: 3_STAR synonym: "(-)-arterenol" RELATED [ChemIDplus] synonym: "(-)-noradrenaline" RELATED [IUPHAR] synonym: "(-)-norepinephrine" RELATED [ChemIDplus] synonym: "(R)-(-)-norepinephrine" RELATED [ChemIDplus] synonym: "(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol" RELATED [ChemIDplus] synonym: "(R)-norepinephrine" RELATED [ChemIDplus] synonym: "4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol" RELATED [KEGG_COMPOUND] synonym: "4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] synonym: "Arterenol" RELATED [KEGG_COMPOUND] synonym: "L-Noradrenaline" RELATED [KEGG_COMPOUND] synonym: "L-NOREPINEPHRINE" RELATED [PDBeChem] synonym: "Noradrenaline" RELATED [KEGG_COMPOUND] synonym: "norepinefrina" RELATED INN [ChEBI] synonym: "Norepinephrine" RELATED [KEGG_COMPOUND] synonym: "norepinephrine" RELATED INN [ChemIDplus] synonym: "norepinephrine" RELATED INN [WHO_MedNet] synonym: "norepinephrinum" RELATED INN [ChEBI] xref: Beilstein:4231961 {source="ChemIDplus"} xref: CAS:51-41-2 {source="ChemIDplus"} xref: CAS:51-41-2 {source="KEGG COMPOUND"} xref: Drug_Central:1960 {source="DrugCentral"} xref: DrugBank:DB00368 xref: HMDB:HMDB0000216 xref: KEGG:C00547 xref: KEGG:D00076 xref: KNApSAcK:C00001424 xref: PDBeChem:LNR xref: Reaxys:2804840 {source="Reaxys"} xref: Wikipedia:Norepinephrine is_a: CHEBI:33569 ! noradrenaline relationship: is_conjugate_base_of CHEBI:72587 ! (R)-noradrenaline(1+) relationship: is_enantiomer_of CHEBI:33571 ! (S)-noradrenaline relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent relationship: RO:0000087 CHEBI:35569 ! has role alpha-adrenergic agonist relationship: RO:0000087 CHEBI:50514 ! has role vasoconstrictor agent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:20664 name: 5beta-cholane namespace: chebi_ontology subset: 3_STAR synonym: "5beta-cholane" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:2048472 {source="Beilstein"} is_a: CHEBI:35519 ! cholane [Term] id: CHEBI:22221 name: acyl group namespace: chebi_ontology def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." [] subset: 3_STAR synonym: "acyl group" EXACT [IUPAC] synonym: "acyl groups" RELATED [ChEBI] synonym: "alkanoyl" EXACT IUPAC_NAME [IUPAC] synonym: "alkanoyl group" RELATED [ChEBI] synonym: "groupe acyle" RELATED [IUPAC] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:22314 name: alkali metal atom namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal" RELATED [ChEBI] synonym: "alkali metals" EXACT IUPAC_NAME [IUPAC] synonym: "Alkalimetall" RELATED [ChEBI] synonym: "Alkalimetalle" RELATED [ChEBI] synonym: "metal alcalin" RELATED [ChEBI] synonym: "metal alcalino" RELATED [ChEBI] synonym: "metales alcalinos" RELATED [ChEBI] synonym: "metaux alcalins" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22315 name: alkaloid namespace: chebi_ontology def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." [] subset: 3_STAR synonym: "alcaloide" RELATED [ChEBI] synonym: "alcaloides" RELATED [ChEBI] synonym: "Alkaloid" EXACT [ChEBI] synonym: "Alkaloide" RELATED [ChEBI] synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Alkaloid is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:22506 name: aminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycans" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative [Term] id: CHEBI:22563 name: anion namespace: chebi_ontology def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." [] subset: 3_STAR synonym: "Anion" EXACT [ChEBI] synonym: "anion" EXACT IUPAC_NAME [IUPAC] synonym: "anion" EXACT [ChEBI] synonym: "Anionen" RELATED [ChEBI] synonym: "aniones" RELATED [ChEBI] synonym: "anions" RELATED [IUPAC] is_a: CHEBI:24870 ! ion [Term] id: CHEBI:22586 name: antioxidant namespace: chebi_ontology def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." [] subset: 3_STAR synonym: "antioxidants" RELATED [ChEBI] synonym: "antioxydant" RELATED [ChEBI] synonym: "antoxidant" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22695 name: base namespace: chebi_ontology def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." [] subset: 3_STAR synonym: "Base" EXACT [ChEBI] synonym: "base" EXACT [ChEBI] synonym: "base" EXACT IUPAC_NAME [IUPAC] synonym: "Base1" RELATED [KEGG_COMPOUND] synonym: "Base2" RELATED [KEGG_COMPOUND] synonym: "Basen" RELATED [ChEBI] synonym: "bases" RELATED [ChEBI] synonym: "Nucleobase" RELATED [KEGG_COMPOUND] xref: KEGG:C00701 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22728 name: benzopyrrole namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrroles" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:228364 name: NMR chemical shift reference compound namespace: chebi_ontology def: "Any compound that produces a peak used as reference frequency in the delta chemical shift scale." [] subset: 3_STAR synonym: "NMR chemical shift reference compounds" RELATED [ChEBI] synonym: "NMR chemical shift standard" RELATED [ChEBI] synonym: "NMR chemical shift standards" RELATED [ChEBI] synonym: "NMR internal standard" RELATED [ChEBI] synonym: "NMR internal standards" RELATED [ChEBI] synonym: "NMR reference standard" RELATED [ChEBI] synonym: "NMR reference standards" RELATED [ChEBI] is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22868 name: bile salt namespace: chebi_ontology def: "A sodium salt of the conjugate of any bile acid with either glycine or taurine." [] subset: 3_STAR synonym: "Bile acid" RELATED [KEGG_COMPOUND] synonym: "bile salts" RELATED [ChEBI] xref: KEGG:C01558 is_a: CHEBI:36078 ! cholanoid is_a: CHEBI:38700 ! organic sodium salt [Term] id: CHEBI:23004 name: carbamoyl group namespace: chebi_ontology def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." [] subset: 3_STAR synonym: "-C(O)NH2" RELATED [ChEBI] synonym: "-CONH2" RELATED [IUPAC] synonym: "aminocarbonyl" RELATED [IUPAC] synonym: "carbamoyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbamyl" RELATED [ChEBI] synonym: "carbamyl group" RELATED [ChEBI] synonym: "carboxamide" RELATED [IUPAC] xref: PMID:24168430 {source="Europe PMC"} is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid [Term] id: CHEBI:23019 name: carbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=O" RELATED [IUPAC] synonym: "carbonyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbonyl group" EXACT [UniProt] synonym: "carbonyl group" EXACT [ChEBI] is_a: CHEBI:51422 ! organodiyl group [Term] id: CHEBI:23357 name: cofactor namespace: chebi_ontology def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." [] subset: 3_STAR synonym: "cofactor" EXACT [IUPAC] synonym: "cofactors" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Cofactor_(biochemistry) is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] subset: 3_STAR synonym: "entidad molecular" RELATED [IUPAC] synonym: "entidades moleculares" RELATED [IUPAC] synonym: "entite moleculaire" RELATED [IUPAC] synonym: "molecular entities" RELATED [IUPAC] synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "molekulare Entitaet" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:23449 name: cyclic peptide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic peptides" RELATED [ChEBI] synonym: "Cyclopeptid" RELATED [ChEBI] synonym: "peptide cyclique" RELATED [IUPAC] synonym: "peptido ciclico" RELATED [IUPAC] synonym: "Zyklopeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23888 name: drug namespace: chebi_ontology def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." [] subset: 3_STAR synonym: "drugs" RELATED [ChEBI] synonym: "medicine" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:23906 name: monoatomic cation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic cations" RELATED [ChEBI] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:23924 name: enzyme inhibitor namespace: chebi_ontology def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." [] subset: 3_STAR synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "enzyme inhibitors" RELATED [ChEBI] synonym: "inhibidor enzimatico" RELATED [ChEBI] synonym: "inhibidores enzimaticos" RELATED [ChEBI] synonym: "inhibiteur enzymatique" RELATED [ChEBI] synonym: "inhibiteurs enzymatiques" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:24384 name: glycogens namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:37163 ! glucan [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] [Term] id: CHEBI:24432 name: biological role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a biological context." [] subset: 3_STAR synonym: "biological function" RELATED [ChEBI] is_a: CHEBI:50906 ! role [Term] id: CHEBI:24433 name: group namespace: chebi_ontology def: "A defined linked collection of atoms or a single atom within a molecular entity." [] subset: 3_STAR synonym: "group" EXACT IUPAC_NAME [IUPAC] synonym: "groupe" RELATED [IUPAC] synonym: "grupo" RELATED [IUPAC] synonym: "grupos" RELATED [IUPAC] synonym: "Gruppe" RELATED [ChEBI] synonym: "Rest" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:33250 ! atom [Term] id: CHEBI:24532 name: organic heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." [] subset: 3_STAR synonym: "organic heterocycle" RELATED [ChEBI] synonym: "organic heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:24533 name: heterodetic cyclic peptide namespace: chebi_ontology def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." [] subset: 3_STAR synonym: "heterodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC] synonym: "heterodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique heterodetique" RELATED [IUPAC] synonym: "peptido ciclico heterodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24621 name: hormone namespace: chebi_ontology def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." [] subset: 3_STAR synonym: "endocrine" RELATED [ChEBI] synonym: "hormones" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] subset: 3_STAR is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:43176 ! hydroxy group [Term] id: CHEBI:24663 name: hydroxy-5beta-cholanic acid namespace: chebi_ontology def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." [] subset: 3_STAR synonym: "hydroxy-5beta-cholanic acids" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:36248 ! 5beta-cholanic acids relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid [Term] id: CHEBI:24828 name: indoles namespace: chebi_ontology def: "Any compound containing an indole skeleton." [] subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24833 name: oxoacid namespace: chebi_ontology def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "oxacids" RELATED [ChEBI] synonym: "oxiacids" RELATED [ChEBI] synonym: "oxo acid" RELATED [ChEBI] synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC] synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC] synonym: "oxy-acids" RELATED [ChEBI] synonym: "oxyacids" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24651 ! hydroxides relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid [Term] id: CHEBI:24834 name: inorganic anion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36914 ! inorganic ion [Term] id: CHEBI:24835 name: inorganic molecular entity namespace: chebi_ontology def: "A molecular entity that contains no carbon." [] subset: 3_STAR synonym: "anorganische Verbindungen" RELATED [ChEBI] synonym: "inorganic compounds" RELATED [ChEBI] synonym: "inorganic entity" RELATED [ChEBI] synonym: "inorganic molecular entities" RELATED [ChEBI] synonym: "inorganics" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24836 name: inorganic oxide namespace: chebi_ontology subset: 3_STAR synonym: "inorganic oxides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide [Term] id: CHEBI:24866 name: salt namespace: chebi_ontology def: "A salt is an assembly of cations and anions." [] subset: 3_STAR synonym: "ionic compound" RELATED [ChEBI] synonym: "ionic compounds" RELATED [ChEBI] synonym: "sal" RELATED [ChEBI] synonym: "sales" RELATED [ChEBI] synonym: "salt" EXACT IUPAC_NAME [IUPAC] synonym: "salts" RELATED [ChEBI] synonym: "Salz" RELATED [ChEBI] synonym: "Salze" RELATED [ChEBI] synonym: "sel" RELATED [ChEBI] synonym: "sels" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:22563 ! anion relationship: has_part CHEBI:36916 ! cation [Term] id: CHEBI:24867 name: monoatomic ion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:24868 name: organic salt namespace: chebi_ontology subset: 3_STAR synonym: "organic salts" RELATED [ChEBI] synonym: "organisches Salz" RELATED [ChEBI] is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24870 name: ion namespace: chebi_ontology def: "A molecular entity having a net electric charge." [] subset: 3_STAR synonym: "Ion" EXACT [ChEBI] synonym: "ion" EXACT IUPAC_NAME [IUPAC] synonym: "ion" EXACT [ChEBI] synonym: "Ionen" RELATED [ChEBI] synonym: "iones" RELATED [ChEBI] synonym: "ions" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:25046 name: linear tetrapyrrole namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26932 ! tetrapyrrole [Term] id: CHEBI:25212 name: metabolite namespace: chebi_ontology alt_id: CHEBI:26619 alt_id: CHEBI:35220 def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." [] subset: 3_STAR synonym: "metabolite" EXACT IUPAC_NAME [IUPAC] synonym: "metabolites" RELATED [ChEBI] synonym: "primary metabolites" RELATED [ChEBI] synonym: "secondary metabolites" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:25213 name: metal cation namespace: chebi_ontology subset: 3_STAR synonym: "a metal cation" RELATED [UniProt] synonym: "metal cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:25362 name: elemental molecule namespace: chebi_ontology def: "A molecule all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic molecule" RELATED [ChEBI] synonym: "homoatomic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:25367 name: molecule namespace: chebi_ontology def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." [] subset: 3_STAR synonym: "molecula" RELATED [IUPAC] synonym: "molecule" EXACT [IUPAC] synonym: "molecules" RELATED [IUPAC] synonym: "Molekuel" RELATED [ChEBI] synonym: "neutral molecular compounds" RELATED [IUPAC] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25375 name: monoamine molecular messenger namespace: chebi_ontology def: "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [] subset: 3_STAR synonym: "monamines" RELATED [ChEBI] synonym: "monoamines" RELATED [ChEBI] is_a: CHEBI:63534 ! monoamine relationship: RO:0000087 CHEBI:33280 ! has role molecular messenger [Term] id: CHEBI:25384 name: monocarboxylic acid namespace: chebi_ontology def: "An oxoacid containing a single carboxy group." [] subset: 3_STAR synonym: "monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion [Term] id: CHEBI:25414 name: monoatomic monocation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monocations" RELATED [ChEBI] synonym: "monovalent inorganic cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:25512 name: neurotransmitter namespace: chebi_ontology def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." [] subset: 3_STAR synonym: "neurotransmitters" RELATED [ChEBI] xref: Wikipedia:Neurotransmitter is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:25555 name: nitrogen atom namespace: chebi_ontology subset: 3_STAR synonym: "7N" RELATED [IUPAC] synonym: "azote" RELATED [IUPAC] synonym: "N" RELATED [IUPAC] synonym: "nitrogen" EXACT IUPAC_NAME [IUPAC] synonym: "nitrogen" RELATED [ChEBI] synonym: "nitrogeno" RELATED [ChEBI] synonym: "Stickstoff" RELATED [ChEBI] xref: WebElements:N is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:25585 name: nonmetal atom namespace: chebi_ontology subset: 3_STAR synonym: "Nichtmetall" RELATED [ChEBI] synonym: "Nichtmetalle" RELATED [ChEBI] synonym: "no metal" RELATED [ChEBI] synonym: "no metales" RELATED [ChEBI] synonym: "non-metal" RELATED [ChEBI] synonym: "non-metaux" RELATED [ChEBI] synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC] synonym: "nonmetal" RELATED [ChEBI] synonym: "nonmetals" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:25696 name: organic anion namespace: chebi_ontology def: "Any organic ion with a net negative charge." [] subset: 3_STAR synonym: "organic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion [Term] id: CHEBI:25697 name: organic cation namespace: chebi_ontology def: "Any organic ion with a net positive charge." [] subset: 3_STAR synonym: "organic cations" RELATED [ChEBI] is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:25699 name: organic ion namespace: chebi_ontology subset: 3_STAR synonym: "organic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:25704 name: organic sulfate namespace: chebi_ontology def: "Compounds of the general formula SO3HOR where R is an organyl group" [] subset: 3_STAR synonym: "organic sulfates" RELATED [ChEBI] is_a: CHEBI:26820 ! sulfates relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion [Term] id: CHEBI:25741 name: oxide namespace: chebi_ontology def: "An oxide is a chemical compound of oxygen with other chemical elements." [] subset: 3_STAR synonym: "oxide" EXACT [ChEBI] synonym: "oxides" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25805 name: oxygen atom namespace: chebi_ontology subset: 3_STAR synonym: "8O" RELATED [IUPAC] synonym: "O" RELATED [IUPAC] synonym: "oxigeno" RELATED [ChEBI] synonym: "oxygen" EXACT IUPAC_NAME [IUPAC] synonym: "oxygen" RELATED [ChEBI] synonym: "oxygene" RELATED [ChEBI] synonym: "Sauerstoff" RELATED [ChEBI] xref: KEGG:C00007 xref: WebElements:O is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "oxygen molecular entities" RELATED [ChEBI] synonym: "oxygen molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:25805 ! oxygen atom [Term] id: CHEBI:25905 name: peptide hormone namespace: chebi_ontology def: "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." [] subset: 3_STAR synonym: "peptide hormones" RELATED [ChEBI] synonym: "polypeptide hormone" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide relationship: RO:0000087 CHEBI:24621 ! has role hormone [Term] id: CHEBI:26708 name: sodium atom namespace: chebi_ontology subset: 3_STAR synonym: "11Na" RELATED [IUPAC] synonym: "Na" RELATED [IUPAC] synonym: "Natrium" RELATED [ChemIDplus] synonym: "natrium" RELATED [IUPAC] synonym: "sodio" RELATED [ChemIDplus] synonym: "sodium" EXACT IUPAC_NAME [IUPAC] synonym: "sodium" RELATED [ChEBI] xref: CAS:7440-23-5 {source="ChemIDplus"} xref: Gmelin:16221 {source="Gmelin"} xref: KEGG:C01330 xref: WebElements:Na is_a: BFO:0000004 ! independent continuant is_a: CHEBI:22314 ! alkali metal atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite [Term] id: CHEBI:26712 name: sodium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sodium compounds" RELATED [ChEBI] synonym: "sodium molecular entities" RELATED [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: has_part CHEBI:26708 ! sodium atom [Term] id: CHEBI:26714 name: sodium salt namespace: chebi_ontology def: "Any alkali metal salt having sodium(1+) as the cation." [] subset: 3_STAR synonym: "Natriumsalz" RELATED [ChEBI] synonym: "Natriumsalze" RELATED [ChEBI] synonym: "sodium salts" RELATED [ChEBI] is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: has_part CHEBI:29101 ! sodium(1+) [Term] id: CHEBI:26764 name: steroid hormone namespace: chebi_ontology def: "Any steroid that acts as hormone." [] subset: 3_STAR synonym: "hormona esteroide" RELATED [ChEBI] synonym: "hormonas esteroideas" RELATED [ChEBI] synonym: "hormone steroide" RELATED [ChEBI] synonym: "hormones steroides" RELATED [ChEBI] synonym: "steroid hormones" RELATED [ChEBI] synonym: "Steroidhormon" RELATED [ChEBI] synonym: "Steroidhormone" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35341 ! steroid relationship: RO:0000087 CHEBI:24621 ! has role hormone [Term] id: CHEBI:26819 name: sulfuric ester namespace: chebi_ontology def: "An ester of an alcohol and sulfuric acid." [] subset: 3_STAR synonym: "sulfate ester" RELATED [ChEBI] synonym: "sulfuric acid ester" RELATED [ChEBI] synonym: "sulfuric acid esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26820 name: sulfates namespace: chebi_ontology def: "Salts and esters of sulfuric acid" [] subset: 3_STAR synonym: "sulfates" EXACT [ChEBI] synonym: "sulfuric acid derivative" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26833 name: sulfur atom namespace: chebi_ontology subset: 3_STAR synonym: "16S" RELATED [IUPAC] synonym: "azufre" RELATED [ChEBI] synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND] synonym: "S" RELATED [IUPAC] synonym: "S" RELATED [KEGG_COMPOUND] synonym: "Schwefel" RELATED [ChEBI] synonym: "soufre" RELATED [ChEBI] synonym: "sulfur" EXACT IUPAC_NAME [IUPAC] synonym: "sulfur" RELATED [ChEBI] synonym: "sulfur" RELATED [UniProt] synonym: "sulphur" RELATED [ChEBI] synonym: "theion" RELATED [IUPAC] xref: CAS:7704-34-9 {source="ChemIDplus"} xref: CAS:7704-34-9 {source="NIST Chemistry WebBook"} xref: KEGG:C00087 xref: KEGG:D06527 xref: PPDB:605 xref: WebElements:S is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:26835 name: sulfur molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sulfur molecular entities" RELATED [ChEBI] synonym: "sulfur molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:26833 ! sulfur atom [Term] id: CHEBI:26836 name: sulfuric acid namespace: chebi_ontology def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." [] subset: 3_STAR synonym: "[S(OH)2O2]" RELATED [MolBase] synonym: "[SO2(OH)2]" RELATED [IUPAC] synonym: "Acide sulfurique" RELATED [ChemIDplus] synonym: "Acido sulfurico" RELATED [ChemIDplus] synonym: "Acidum sulfuricum" RELATED [ChemIDplus] synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "H2SO4" RELATED [IUPAC] synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus] synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND] synonym: "sulfuric acid" EXACT IUPAC_NAME [IUPAC] synonym: "sulfuric acid" EXACT [ChEBI] synonym: "sulphuric acid" RELATED [MolBase] synonym: "tetraoxosulfuric acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:7664-93-9 {source="ChemIDplus"} xref: CAS:7664-93-9 {source="KEGG COMPOUND"} xref: CAS:7664-93-9 {source="NIST Chemistry WebBook"} xref: Gmelin:2122 {source="Gmelin"} xref: KEGG:C00059 xref: KEGG:D05963 xref: KNApSAcK:C00007530 xref: MolBase:4 xref: PMID:13568755 {source="Europe PMC"} xref: PMID:16122922 {source="Europe PMC"} xref: PMID:19397353 {source="Europe PMC"} xref: PMID:22047659 {source="Europe PMC"} xref: PMID:22136045 {source="Europe PMC"} xref: PMID:22204399 {source="Europe PMC"} xref: PMID:22267186 {source="Europe PMC"} xref: PMID:22296037 {source="Europe PMC"} xref: PMID:22364556 {source="Europe PMC"} xref: PMID:22435616 {source="Europe PMC"} xref: PPDB:606 xref: Reaxys:2037554 {source="Reaxys"} xref: Wikipedia:Sulfuric_acid is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:35223 ! has role catalyst [Term] id: CHEBI:26932 name: tetrapyrrole namespace: chebi_ontology def: "A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [] subset: 3_STAR synonym: "a tetrapyrrole" RELATED [UniProt] synonym: "tetrapyrrole" EXACT IUPAC_NAME [IUPAC] synonym: "tetrapyrroles" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38077 ! polypyrrole [Term] id: CHEBI:27027 name: micronutrient namespace: chebi_ontology def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." [] subset: 3_STAR synonym: "micronutrients" RELATED [ChEBI] synonym: "trace elements" RELATED [ChEBI] xref: Wikipedia:Micronutrient is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:27162 name: tryptamines namespace: chebi_ontology def: "Tryptamine and its substitution derivatives." [] subset: 3_STAR is_a: CHEBI:24828 ! indoles [Term] id: CHEBI:27171 name: organic heterobicyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterobicyclic compounds" RELATED [ChEBI] synonym: "organic heterobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33672 ! heterobicyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:27207 name: univalent carboacyl group namespace: chebi_ontology def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "univalent acyl group" RELATED [ChEBI] synonym: "univalent carboacyl groups" RELATED [ChEBI] synonym: "univalent carboxylic acyl groups" RELATED [ChEBI] is_a: CHEBI:37838 ! carboacyl group [Term] id: CHEBI:27369 name: zwitterion namespace: chebi_ontology def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." [] subset: 3_STAR synonym: "compose zwitterionique" RELATED [IUPAC] synonym: "compuestos zwitterionicos" RELATED [IUPAC] synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC] synonym: "zwitteriones" RELATED [IUPAC] synonym: "zwitterionic compounds" RELATED [IUPAC] synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51151 ! dipolar compound [Term] id: CHEBI:27594 name: carbon atom namespace: chebi_ontology alt_id: CHEBI:23009 alt_id: CHEBI:3399 subset: 3_STAR synonym: "6C" RELATED [IUPAC] synonym: "C" RELATED [KEGG_COMPOUND] synonym: "C" RELATED [IUPAC] synonym: "Carbon" RELATED [KEGG_COMPOUND] synonym: "carbon" EXACT IUPAC_NAME [IUPAC] synonym: "carbon" RELATED [ChEBI] synonym: "carbone" RELATED [ChEBI] synonym: "carbonium" RELATED [ChEBI] synonym: "carbono" RELATED [ChEBI] synonym: "Kohlenstoff" RELATED [ChEBI] xref: CAS:7440-44-0 {source="KEGG COMPOUND"} xref: CAS:7440-44-0 {source="ChemIDplus"} xref: KEGG:C06265 xref: WebElements:C is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33306 ! carbon group element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:28087 name: glycogen namespace: chebi_ontology alt_id: CHEBI:24379 alt_id: CHEBI:5466 def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." [] subset: 3_STAR synonym: "animal starch" RELATED [ChemIDplus] synonym: "Glycogen" EXACT [KEGG_COMPOUND] synonym: "liver starch" RELATED [ChemIDplus] synonym: "WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1" RELATED [GlyTouCan] xref: CAS:9005-79-2 {source="KEGG COMPOUND"} xref: CAS:9005-79-2 {source="ChemIDplus"} xref: GlyGen:G99991IU xref: GlyTouCan:G99991IU xref: HMDB:HMDB0000757 xref: KEGG:C00182 xref: MetaCyc:CPD0-971 xref: Wikipedia:Glycogen is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24384 ! glycogens relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:28616 name: carbamic acid namespace: chebi_ontology alt_id: CHEBI:22504 alt_id: CHEBI:23002 alt_id: CHEBI:3386 alt_id: CHEBI:44573 def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." [] subset: 3_STAR synonym: "Aminoameisensaeure" RELATED [ChEBI] synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND] synonym: "Carbamate" RELATED [KEGG_COMPOUND] synonym: "CARBAMIC ACID" EXACT [PDBeChem] synonym: "Carbamic acid" EXACT [KEGG_COMPOUND] synonym: "carbamic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Carbamidsaeure" RELATED [ChEBI] xref: Beilstein:1734754 {source="Beilstein"} xref: CAS:463-77-4 {source="KEGG COMPOUND"} xref: CAS:463-77-4 {source="ChemIDplus"} xref: DrugBank:DB04261 xref: Gmelin:130345 {source="Gmelin"} xref: KEGG:C01563 xref: PDBeChem:OUT xref: Wikipedia:Carbamic_acid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:28790 name: serotonin namespace: chebi_ontology alt_id: CHEBI:1420 alt_id: CHEBI:26652 alt_id: CHEBI:49894 def: "A primary amino compound that is the 5-hydroxy derivative of tryptamine." [] subset: 3_STAR synonym: "3-(2-Aminoethyl)-1H-indol-5-ol" RELATED [KEGG_COMPOUND] synonym: "3-(2-aminoethyl)-1H-indol-5-ol" EXACT IUPAC_NAME [IUPAC] synonym: "5-HT" RELATED [IUPHAR] synonym: "5-Hydroxytryptamine" RELATED [KEGG_COMPOUND] synonym: "Enteramine" RELATED [KEGG_COMPOUND] synonym: "SEROTONIN" EXACT [PDBeChem] synonym: "Serotonin" EXACT [KEGG_COMPOUND] synonym: "serotonine" RELATED [ChEBI] synonym: "thrombocytin" RELATED [ChemIDplus] synonym: "thrombotonin" RELATED [ChemIDplus] xref: CAS:50-67-9 {source="KEGG COMPOUND"} xref: CAS:50-67-9 {source="ChemIDplus"} xref: Gmelin:1861995 {source="Gmelin"} xref: HMDB:HMDB0000259 xref: KEGG:C00780 xref: KNApSAcK:C00001429 xref: LINCS:LSM-6589 xref: MetaCyc:SEROTONIN xref: PDBeChem:SRO xref: PMID:18593914 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:24136337 {source="Europe PMC"} xref: Reaxys:143524 {source="Reaxys"} xref: Wikipedia:Serotonin is_a: CHEBI:25375 ! monoamine molecular messenger is_a: CHEBI:27162 ! tryptamines is_a: CHEBI:33853 ! phenols is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:84729 ! hydroxyindoles relationship: has_functional_parent CHEBI:16765 ! tryptamine relationship: is_conjugate_base_of CHEBI:350546 ! serotonin(1+) relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:28938 name: ammonium namespace: chebi_ontology alt_id: CHEBI:22534 alt_id: CHEBI:49783 alt_id: CHEBI:7435 def: "An onium cation obtained by protonation of ammonia." [] subset: 3_STAR synonym: "[NH4](+)" RELATED [MolBase] synonym: "ammonium" EXACT [ChEBI] synonym: "ammonium" EXACT IUPAC_NAME [IUPAC] synonym: "ammonium cation" RELATED [ChemIDplus] synonym: "ammonium ion" RELATED [PDBeChem] synonym: "Ammonium(1+)" RELATED [ChemIDplus] synonym: "azanium" EXACT IUPAC_NAME [IUPAC] synonym: "NH4(+)" RELATED [UniProt] synonym: "NH4(+)" RELATED [IUPAC] synonym: "NH4+" RELATED [KEGG_COMPOUND] xref: CAS:14798-03-9 {source="NIST Chemistry WebBook"} xref: CAS:14798-03-9 {source="ChemIDplus"} xref: Gmelin:84 {source="Gmelin"} xref: KEGG:C01342 xref: MetaCyc:AMMONIUM xref: MolBase:929 xref: PDBeChem:NH4 xref: PMID:11319011 {source="Europe PMC"} xref: PMID:11341317 {source="Europe PMC"} xref: PMID:12096804 {source="Europe PMC"} xref: PMID:14512268 {source="Europe PMC"} xref: PMID:14879753 {source="Europe PMC"} xref: PMID:16345391 {source="Europe PMC"} xref: PMID:16903292 {source="Europe PMC"} xref: PMID:17392693 {source="Europe PMC"} xref: PMID:18515490 {source="Europe PMC"} xref: PMID:19199063 {source="Europe PMC"} xref: PMID:19596600 {source="Europe PMC"} xref: PMID:19682559 {source="Europe PMC"} xref: PMID:19716251 {source="Europe PMC"} xref: PMID:21993530 {source="Europe PMC"} xref: PMID:22265469 {source="Europe PMC"} xref: PMID:22524020 {source="Europe PMC"} xref: PMID:22562341 {source="Europe PMC"} xref: PMID:22631217 {source="Europe PMC"} xref: Reaxys:16093784 {source="Reaxys"} xref: Wikipedia:Ammonium is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:50313 ! onium cation is_a: CHEBI:60242 ! monovalent inorganic cation relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:28965 name: dicarboxylic acid dianion namespace: chebi_ontology alt_id: CHEBI:13632 alt_id: CHEBI:23688 alt_id: CHEBI:23689 alt_id: CHEBI:38711 def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." [] subset: 3_STAR synonym: "a dicarboxylate" RELATED [UniProt] synonym: "dicarboxylate" RELATED [ChEBI] synonym: "dicarboxylates" RELATED [ChEBI] synonym: "dicarboxylic acid dianion" EXACT [ChEBI] synonym: "dicarboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion is_a: CHEBI:38716 ! carboxylic acid dianion [Term] id: CHEBI:28976 name: carbonic acid namespace: chebi_ontology alt_id: CHEBI:13351 alt_id: CHEBI:23017 alt_id: CHEBI:23744 alt_id: CHEBI:3401 subset: 3_STAR synonym: "[CO(OH)2]" RELATED [IUPAC] synonym: "Carbonic acid" EXACT [KEGG_COMPOUND] synonym: "carbonic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND] synonym: "dihydroxidooxidocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "H2CO3" RELATED [KEGG_COMPOUND] synonym: "H2CO3" RELATED [IUPAC] synonym: "Koehlensaeure" RELATED [ChEBI] xref: CAS:463-79-6 {source="ChemIDplus"} xref: CAS:463-79-6 {source="KEGG COMPOUND"} xref: Gmelin:25554 {source="Gmelin"} xref: KEGG:C01353 xref: PDBeChem:CO3 is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36961 ! chalcocarbonic acid relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:29067 name: carboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13626 alt_id: CHEBI:13945 alt_id: CHEBI:23026 alt_id: CHEBI:58657 def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a carboxylate" RELATED [UniProt] synonym: "carboxylic acid anions" RELATED [ChEBI] synonym: "carboxylic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:29101 name: sodium(1+) namespace: chebi_ontology alt_id: CHEBI:26717 alt_id: CHEBI:49766 alt_id: CHEBI:9175 def: "A monoatomic monocation obtained from sodium." [] subset: 3_STAR synonym: "Na(+)" RELATED [UniProt] synonym: "Na(+)" RELATED [IUPAC] synonym: "Na+" RELATED [KEGG_COMPOUND] synonym: "sodium cation" EXACT IUPAC_NAME [IUPAC] synonym: "SODIUM ION" RELATED [PDBeChem] synonym: "sodium(1+)" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(1+) ion" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(I) cation" EXACT IUPAC_NAME [IUPAC] xref: CAS:17341-25-2 {source="ChemIDplus"} xref: CAS:17341-25-2 {source="NIST Chemistry WebBook"} xref: Gmelin:15196 {source="Gmelin"} xref: KEGG:C01330 xref: PDBeChem:NA is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37246 ! elemental sodium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:29337 name: azanide namespace: chebi_ontology subset: 3_STAR synonym: "amide" EXACT IUPAC_NAME [IUPAC] synonym: "azanide" EXACT IUPAC_NAME [IUPAC] synonym: "dihydridonitrate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "NH2(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-) relationship: is_conjugate_base_of CHEBI:16134 ! ammonia [Term] id: CHEBI:29340 name: hydridonitrate(2-) namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." [] subset: 3_STAR synonym: "azanediide" EXACT IUPAC_NAME [IUPAC] synonym: "hydridonitrate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "imide" RELATED [IUPAC] synonym: "NH(2-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29337 ! azanide [Term] id: CHEBI:29793 name: hydridodioxygen(1+) namespace: chebi_ontology subset: 3_STAR synonym: "[HO2](+)" RELATED [ChEBI] synonym: "dioxidenium" EXACT IUPAC_NAME [IUPAC] synonym: "HO2(+)" RELATED [IUPAC] synonym: "HOO(+)" RELATED [ChEBI] synonym: "hydridodioxygen(1+)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:508 {source="Gmelin"} is_a: CHEBI:33693 ! oxygen hydride relationship: is_conjugate_acid_of CHEBI:15379 ! dioxygen [Term] id: CHEBI:30089 name: acetate namespace: chebi_ontology alt_id: CHEBI:13704 alt_id: CHEBI:22165 alt_id: CHEBI:40480 def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." [] subset: 3_STAR synonym: "acetate" EXACT [UniProt] synonym: "acetate" EXACT IUPAC_NAME [IUPAC] synonym: "ACETATE ION" RELATED [PDBeChem] synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Azetat" RELATED [ChEBI] synonym: "CH3-COO(-)" RELATED [IUPAC] synonym: "Ethanoat" RELATED [ChEBI] synonym: "ethanoate" RELATED [ChEBI] synonym: "MeCO2 anion" RELATED [NIST_Chemistry_WebBook] xref: CAS:71-50-1 {source="ChemIDplus"} xref: CAS:71-50-1 {source="NIST Chemistry WebBook"} xref: DrugBank:DB03166 xref: Gmelin:1379 {source="Gmelin"} xref: KEGG:C00033 xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PMID:17190852 {source="Europe PMC"} xref: PMID:22211106 {source="Europe PMC"} xref: PMID:22371380 {source="Europe PMC"} xref: Reaxys:1901470 {source="Reaxys"} xref: UM-BBD_compID:c0050 {source="UM-BBD"} xref: Wikipedia:Acetate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:30212 name: photon namespace: chebi_ontology alt_id: CHEBI:10581 alt_id: CHEBI:14383 def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force." [] subset: 3_STAR synonym: "foton" RELATED [ChEBI] synonym: "gamma" RELATED [IUPAC] synonym: "hnu" RELATED [IUPAC] synonym: "hnu" RELATED [UniProt] synonym: "Lichtquant" RELATED [ChEBI] synonym: "Light" RELATED [KEGG_COMPOUND] synonym: "light quantum" RELATED [ChEBI] synonym: "photon" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00205 is_a: CHEBI:36341 ! boson [Term] id: CHEBI:3098 name: bile acid namespace: chebi_ontology def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." [] subset: 3_STAR synonym: "5beta-bile acid" RELATED [ChEBI] synonym: "5beta-bile acids" RELATED [ChEBI] synonym: "Bile acid" EXACT [KEGG_COMPOUND] synonym: "bile acids" RELATED [ChEBI] synonym: "Bile salt" RELATED [KEGG_COMPOUND] synonym: "Gallensaeure" RELATED [ChEBI] synonym: "Gallensaeuren" RELATED [ChEBI] xref: KEGG:C01558 is_a: CHEBI:138366 ! bile acids is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid [Term] id: CHEBI:32952 name: amine namespace: chebi_ontology alt_id: CHEBI:13814 alt_id: CHEBI:22474 alt_id: CHEBI:2641 def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "Amin" RELATED [ChEBI] synonym: "Amine" EXACT [KEGG_COMPOUND] synonym: "amines" EXACT IUPAC_NAME [IUPAC] synonym: "Substituted amine" RELATED [KEGG_COMPOUND] xref: KEGG:C00706 is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:32988 name: amide namespace: chebi_ontology alt_id: CHEBI:22473 alt_id: CHEBI:2633 def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "Amide" EXACT [KEGG_COMPOUND] synonym: "amides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00241 is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33232 name: application namespace: chebi_ontology def: "Intended use of the molecular entity or part thereof by humans." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:33233 name: fundamental particle namespace: chebi_ontology def: "A particle not known to have substructure." [] subset: 3_STAR synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC] synonym: "elementary particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:33238 name: monoatomic entity namespace: chebi_ontology def: "A monoatomic entity is a molecular entity consisting of a single atom." [] subset: 3_STAR synonym: "atomic entity" RELATED [ChEBI] synonym: "monoatomic entities" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33241 name: oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_functional_parent CHEBI:24833 ! oxoacid [Term] id: CHEBI:33242 name: inorganic hydride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic hydrides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:33245 name: organic fundamental parent namespace: chebi_ontology def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." [] subset: 3_STAR synonym: "organic fundamental parents" RELATED [ChEBI] synonym: "organic parent hydrides" RELATED [ChEBI] is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33246 name: inorganic group namespace: chebi_ontology def: "Any substituent group which does not contain carbon." [] subset: 3_STAR synonym: "inorganic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:33247 name: organic group namespace: chebi_ontology def: "Any substituent group or skeleton containing carbon." [] subset: 3_STAR synonym: "organic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group [Term] id: CHEBI:33249 name: organyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." [] subset: 3_STAR synonym: "groupe organyle" RELATED [IUPAC] synonym: "grupo organilo" RELATED [IUPAC] synonym: "grupos organilo" RELATED [IUPAC] synonym: "organyl group" EXACT IUPAC_NAME [IUPAC] synonym: "organyl groups" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51447 ! organic univalent group [Term] id: CHEBI:33250 name: atom namespace: chebi_ontology alt_id: CHEBI:22671 alt_id: CHEBI:23907 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." [] subset: 3_STAR synonym: "atom" EXACT IUPAC_NAME [IUPAC] synonym: "atome" RELATED [IUPAC] synonym: "atomo" RELATED [IUPAC] synonym: "atoms" RELATED [ChEBI] synonym: "atomus" RELATED [ChEBI] synonym: "element" RELATED [ChEBI] synonym: "elements" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:10545 ! electron relationship: has_part CHEBI:33252 ! atomic nucleus [Term] id: CHEBI:33252 name: atomic nucleus namespace: chebi_ontology def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." [] subset: 3_STAR synonym: "Atomkern" RELATED [ChEBI] synonym: "Kern" RELATED [ChEBI] synonym: "noyau" RELATED [IUPAC] synonym: "noyau atomique" RELATED [ChEBI] synonym: "nuclei" RELATED [ChEBI] synonym: "nucleo" RELATED [IUPAC] synonym: "nucleo atomico" RELATED [ChEBI] synonym: "nucleus" EXACT IUPAC_NAME [IUPAC] synonym: "nucleus atomi" RELATED [ChEBI] is_a: CHEBI:36347 ! nuclear particle relationship: has_part CHEBI:33253 ! nucleon [Term] id: CHEBI:33253 name: nucleon namespace: chebi_ontology def: "Heavy nuclear particle: proton or neutron." [] subset: 3_STAR synonym: "nucleon" EXACT [IUPAC] synonym: "nucleon" EXACT IUPAC_NAME [IUPAC] synonym: "nucleons" RELATED [ChEBI] synonym: "Nukleon" RELATED [ChEBI] synonym: "Nukleonen" RELATED [ChEBI] is_a: CHEBI:36339 ! baryon is_a: CHEBI:36347 ! nuclear particle [Term] id: CHEBI:33256 name: primary amide namespace: chebi_ontology def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "primary amide" EXACT [IUPAC] synonym: "primary amides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33259 name: elemental molecular entity namespace: chebi_ontology def: "A molecular entity all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic entity" RELATED [ChEBI] synonym: "homoatomic molecular entities" RELATED [ChEBI] synonym: "homoatomic molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33262 name: elemental oxygen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33263 name: diatomic oxygen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33262 ! elemental oxygen [Term] id: CHEBI:33273 name: polyatomic anion namespace: chebi_ontology def: "An anion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion [Term] id: CHEBI:33280 name: molecular messenger namespace: chebi_ontology subset: 3_STAR synonym: "chemical messenger" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33281 name: antimicrobial agent namespace: chebi_ontology alt_id: CHEBI:22582 def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." [] subset: 3_STAR synonym: "antibiotic" RELATED [ChEBI] synonym: "antibiotics" RELATED [ChEBI] synonym: "Antibiotika" RELATED [ChEBI] synonym: "Antibiotikum" RELATED [ChEBI] synonym: "antibiotique" RELATED [IUPAC] synonym: "antimicrobial" RELATED [ChEBI] synonym: "antimicrobial agents" RELATED [ChEBI] synonym: "antimicrobials" RELATED [ChEBI] synonym: "microbicide" RELATED [ChEBI] synonym: "microbicides" RELATED [ChEBI] xref: PMID:12964249 {source="Europe PMC"} xref: PMID:22117953 {source="Europe PMC"} xref: PMID:22439833 {source="Europe PMC"} xref: PMID:22849268 {source="Europe PMC"} xref: PMID:22849276 {source="Europe PMC"} xref: PMID:22958833 {source="Europe PMC"} is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33284 name: nutrient namespace: chebi_ontology def: "A nutrient is a food component that an organism uses to survive and grow." [] subset: 3_STAR synonym: "nutrients" RELATED [ChEBI] is_a: CHEBI:78295 ! food component [Term] id: CHEBI:33285 name: heteroorganic entity namespace: chebi_ontology def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." [] subset: 3_STAR synonym: "heteroorganic entities" RELATED [ChEBI] synonym: "organoelement compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33296 name: alkali metal molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of an alkali metal." [] subset: 3_STAR synonym: "alkali metal molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:22314 ! alkali metal atom [Term] id: CHEBI:33300 name: pnictogen namespace: chebi_ontology def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." [] subset: 3_STAR synonym: "group 15 elements" RELATED [ChEBI] synonym: "group V elements" RELATED [ChEBI] synonym: "nitrogenoideos" RELATED [ChEBI] synonym: "nitrogenoides" RELATED [ChEBI] synonym: "pnictogene" RELATED [ChEBI] synonym: "pnictogenes" RELATED [ChEBI] synonym: "pnictogens" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33302 name: pnictogen molecular entity namespace: chebi_ontology def: "A p-block molecular entity containing any pnictogen." [] subset: 3_STAR synonym: "pnictogen molecular entities" RELATED [ChEBI] synonym: "pnictogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33300 ! pnictogen [Term] id: CHEBI:33303 name: chalcogen namespace: chebi_ontology def: "Any p-block element belonging to the group 16 family of the periodic table." [] subset: 3_STAR synonym: "anfigeno" RELATED [ChEBI] synonym: "anfigenos" RELATED [ChEBI] synonym: "calcogeno" RELATED [ChEBI] synonym: "calcogenos" RELATED [ChEBI] synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC] synonym: "chalcogene" RELATED [ChEBI] synonym: "chalcogenes" RELATED [ChEBI] synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC] synonym: "Chalkogen" RELATED [ChEBI] synonym: "Chalkogene" RELATED [ChEBI] synonym: "group 16 elements" RELATED [ChEBI] synonym: "group VI elements" RELATED [ChEBI] xref: PMID:17084588 {source="Europe PMC"} is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] subset: 3_STAR synonym: "chalcogen compounds" RELATED [ChEBI] synonym: "chalcogen molecular entities" RELATED [ChEBI] synonym: "chalcogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33303 ! chalcogen [Term] id: CHEBI:33306 name: carbon group element atom namespace: chebi_ontology subset: 3_STAR synonym: "carbon group element" RELATED [ChEBI] synonym: "carbon group elements" RELATED [ChEBI] synonym: "carbonoides" RELATED [ChEBI] synonym: "cristallogene" RELATED [ChEBI] synonym: "cristallogenes" RELATED [ChEBI] synonym: "group 14 elements" EXACT IUPAC_NAME [IUPAC] synonym: "group IV elements" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33308 name: carboxylic ester namespace: chebi_ontology alt_id: CHEBI:13204 alt_id: CHEBI:23028 alt_id: CHEBI:3408 def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." [] subset: 3_STAR synonym: "a carboxylic ester" RELATED [UniProt] synonym: "carboxylic acid esters" RELATED [ChEBI] synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND] synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02391 xref: Wikipedia:Ester is_a: CHEBI:35701 ! ester is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:33318 name: main group element atom namespace: chebi_ontology def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." [] subset: 3_STAR synonym: "Hauptgruppenelement" RELATED [ChEBI] synonym: "Hauptgruppenelemente" RELATED [ChEBI] synonym: "main group element" RELATED [ChEBI] synonym: "main group elements" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33402 name: sulfur oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "oxoacids of sulfur" RELATED [ChEBI] synonym: "sulfur oxoacids" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33484 ! chalcogen oxoacid [Term] id: CHEBI:33424 name: sulfur oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfur oxoacid derivative" EXACT [ChEBI] synonym: "sulfur oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative [Term] id: CHEBI:33482 name: sulfur oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of sulfur" RELATED [ChEBI] synonym: "sulfur oxoanion" EXACT [ChEBI] synonym: "sulfur oxoanions" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion [Term] id: CHEBI:33484 name: chalcogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoacid" EXACT [ChEBI] synonym: "chalcogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:33485 name: chalcogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoanion" EXACT [ChEBI] synonym: "chalcogen oxoanions" RELATED [ChEBI] is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33504 name: alkali metal cation namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal cations" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33521 name: metal atom namespace: chebi_ontology alt_id: CHEBI:25217 alt_id: CHEBI:6788 def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." [] subset: 3_STAR synonym: "elemental metal" RELATED [ChEBI] synonym: "elemental metals" RELATED [ChEBI] synonym: "metal element" RELATED [ChEBI] synonym: "metal elements" RELATED [ChEBI] synonym: "metals" RELATED [ChEBI] xref: KEGG:C00050 xref: PMID:21784043 {source="Europe PMC"} xref: Wikipedia:Metal is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33558 name: alpha-amino-acid anion namespace: chebi_ontology def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino acid anion" RELATED [ChEBI] synonym: "alpha-amino acid anions" RELATED [ChEBI] synonym: "alpha-amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33559 name: s-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "s-block element" RELATED [ChEBI] synonym: "s-block elements" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33560 name: p-block element atom namespace: chebi_ontology def: "Any main group element atom belonging to the p-block of the periodic table." [] subset: 3_STAR synonym: "p-block element" RELATED [ChEBI] synonym: "p-block elements" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom [Term] id: CHEBI:33566 name: catechols namespace: chebi_ontology alt_id: CHEBI:134187 alt_id: CHEBI:13628 alt_id: CHEBI:18862 def: "Any compound containing an o-diphenol component." [] subset: 3_STAR synonym: "1,2-benzenediols" RELATED [ChEBI] synonym: "a catechol" RELATED [UniProt] synonym: "benzene-1,2-diols" RELATED [ChEBI] xref: KEGG:C15571 is_a: CHEBI:33570 ! benzenediols [Term] id: CHEBI:33567 name: catecholamine namespace: chebi_ontology alt_id: CHEBI:23056 alt_id: CHEBI:3468 def: "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [] subset: 3_STAR synonym: "Catecholamine" EXACT [KEGG_COMPOUND] synonym: "catecholamines" EXACT IUPAC_NAME [IUPAC] synonym: "catecholamines" RELATED [ChEBI] xref: KEGG:C02012 is_a: CHEBI:25375 ! monoamine molecular messenger is_a: CHEBI:33566 ! catechols [Term] id: CHEBI:33569 name: noradrenaline namespace: chebi_ontology def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." [] subset: 3_STAR synonym: "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] synonym: "noradrenalina" RELATED [ChEBI] synonym: "norepinephrine" RELATED [ChEBI] xref: Beilstein:2210994 {source="Beilstein"} xref: CAS:138-65-8 {source="NIST Chemistry WebBook"} xref: CAS:138-65-8 {source="ChemIDplus"} xref: Gmelin:863925 {source="Gmelin"} xref: LINCS:LSM-5181 is_a: CHEBI:33567 ! catecholamine relationship: is_conjugate_base_of CHEBI:166902 ! noradrenaline(1+) relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite [Term] id: CHEBI:33570 name: benzenediols namespace: chebi_ontology alt_id: CHEBI:22705 alt_id: CHEBI:22711 subset: 3_STAR is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33571 name: (S)-noradrenaline namespace: chebi_ontology def: "The S-enantiomer of noradrenaline." [] subset: 3_STAR synonym: "4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] xref: LINCS:LSM-37072 xref: Reaxys:2937999 {source="Reaxys"} is_a: CHEBI:33569 ! noradrenaline relationship: is_enantiomer_of CHEBI:18357 ! (R)-noradrenaline [Term] id: CHEBI:33575 name: carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13428 alt_id: CHEBI:13627 alt_id: CHEBI:23027 def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." [] subset: 3_STAR synonym: "acide carboxylique" RELATED [IUPAC] synonym: "acides carboxyliques" RELATED [IUPAC] synonym: "acido carboxilico" RELATED [IUPAC] synonym: "acidos carboxilicos" RELATED [IUPAC] synonym: "Carbonsaeure" RELATED [ChEBI] synonym: "Carbonsaeuren" RELATED [ChEBI] synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Karbonsaeure" RELATED [ChEBI] synonym: "RC(=O)OH" RELATED [IUPAC] xref: PMID:17147560 {source="Europe PMC"} xref: PMID:18433345 {source="Europe PMC"} xref: Wikipedia:Carboxylic_acid is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid relationship: has_part CHEBI:46883 ! carboxy group relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] subset: 3_STAR synonym: "main group compounds" RELATED [ChEBI] synonym: "main group molecular entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:33318 ! main group element atom [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "carbon group molecular entities" RELATED [ChEBI] synonym: "carbon group molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33306 ! carbon group element atom [Term] id: CHEBI:33595 name: cyclic compound namespace: chebi_ontology def: "Any molecule that consists of a series of atoms joined together to form a ring." [] subset: 3_STAR synonym: "cyclic compounds" RELATED [ChEBI] xref: Wikipedia:Cyclic_compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "hydrogen compounds" RELATED [ChEBI] synonym: "hydrogen molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:49637 ! hydrogen atom [Term] id: CHEBI:33635 name: polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33636 name: bicyclic compound namespace: chebi_ontology def: "A molecule that features two fused rings." [] subset: 3_STAR synonym: "bicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33655 name: aromatic compound namespace: chebi_ontology def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [] subset: 3_STAR synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "aromatics" RELATED [ChEBI] synonym: "aromatische Verbindungen" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33659 name: organic aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic aromatic compounds" RELATED [ChEBI] is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33671 name: heteropolycyclic compound namespace: chebi_ontology def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." [] subset: 3_STAR synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "polyheterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33672 name: heterobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." [] subset: 3_STAR synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] subset: 3_STAR synonym: "s-block compounds" RELATED [ChEBI] synonym: "s-block molecular entities" RELATED [ChEBI] synonym: "s-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33559 ! s-block element atom [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A main group molecular entity that contains one or more atoms of a p-block element." [] subset: 3_STAR synonym: "p-block compounds" RELATED [ChEBI] synonym: "p-block molecular entities" RELATED [ChEBI] synonym: "p-block molecular entitiy" RELATED [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33692 name: hydrides namespace: chebi_ontology def: "Hydrides are chemical compounds of hydrogen with other chemical elements." [] subset: 3_STAR is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33693 name: oxygen hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of oxygen" RELATED [ChEBI] synonym: "oxygen hydride" EXACT [ChEBI] synonym: "oxygen hydrides" RELATED [ChEBI] is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33694 name: biomacromolecule namespace: chebi_ontology def: "A macromolecule formed by a living organism." [] subset: 3_STAR synonym: "biomacromolecules" RELATED [ChEBI] synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC] synonym: "Biopolymere" RELATED [ChEBI] synonym: "biopolymers" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33695 name: information biomacromolecule namespace: chebi_ontology subset: 3_STAR synonym: "genetically encoded biomacromolecules" RELATED [ChEBI] synonym: "genetically encoded biopolymers" RELATED [ChEBI] synonym: "information biomacromolecules" RELATED [ChEBI] synonym: "information biopolymers" RELATED [ChEBI] synonym: "information macromolecule" RELATED [ChEBI] synonym: "information macromolecules" RELATED [ChEBI] is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:33696 name: nucleic acid namespace: chebi_ontology def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." [] subset: 3_STAR synonym: "acide nucleique" RELATED [ChEBI] synonym: "acides nucleiques" RELATED [ChEBI] synonym: "acido nucleico" RELATED [ChEBI] synonym: "acidos nucleicos" RELATED [ChEBI] synonym: "NA" RELATED [ChEBI] synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Nukleinsaeure" RELATED [ChEBI] synonym: "Nukleinsaeuren" RELATED [ChEBI] is_a: CHEBI:15986 ! polynucleotide relationship: has_part CHEBI:33791 ! canonical nucleoside residue relationship: has_part CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:33697 name: ribonucleic acid namespace: chebi_ontology def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." [] subset: 3_STAR synonym: "pentosenucleic acids" RELATED [ChemIDplus] synonym: "ribonucleic acid" EXACT [IUPAC] synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "ribonucleic acids" RELATED [ChEBI] synonym: "Ribonukleinsaeure" RELATED [ChEBI] synonym: "ribose nucleic acid" RELATED [ChEBI] synonym: "RNA" RELATED [UniProt] synonym: "RNA" RELATED [IUPAC] synonym: "RNS" RELATED [ChEBI] synonym: "yeast nucleic acid" RELATED [ChEBI] xref: CAS:63231-63-0 {source="ChemIDplus"} is_a: CHEBI:33696 ! nucleic acid relationship: has_part CHEBI:33792 ! canonical ribonucleoside residue relationship: has_part CHEBI:50299 ! canonical ribonucleotide residue [Term] id: CHEBI:33700 name: proteinogenic amino-acid residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical amino-acid residue" RELATED [ChEBI] synonym: "canonical amino-acid residues" RELATED [ChEBI] synonym: "common amino acid residues" RELATED [ChEBI] synonym: "proteinogenic amino-acid residues" RELATED [ChEBI] synonym: "standard amino acid residues" RELATED [ChEBI] synonym: "standard amino-acid residues" RELATED [ChEBI] is_a: CHEBI:33710 ! alpha-amino-acid residue [Term] id: CHEBI:33702 name: polyatomic cation namespace: chebi_ontology def: "A cation consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic cations" RELATED [ChEBI] is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:33703 name: amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "amino acid cation" RELATED [ChEBI] synonym: "amino acid cations" RELATED [ChEBI] synonym: "amino-acid cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:33702 ! polyatomic cation relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid [Term] id: CHEBI:33704 name: alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:10208 alt_id: CHEBI:13779 alt_id: CHEBI:22442 alt_id: CHEBI:2642 def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." [] subset: 3_STAR synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-amino acids" RELATED [JCBN] synonym: "alpha-amino acids" RELATED [ChEBI] synonym: "alpha-amino carboxylic acids" RELATED [IUPAC] synonym: "Amino acid" RELATED [KEGG_COMPOUND] synonym: "Amino acids" RELATED [KEGG_COMPOUND] xref: KEGG:C00045 xref: KEGG:C05167 is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation relationship: is_tautomer_of CHEBI:78608 ! alpha-amino-acid zwitterion [Term] id: CHEBI:33708 name: amino-acid residue namespace: chebi_ontology def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [] subset: 3_STAR synonym: "amino acid residue" RELATED [ChEBI] synonym: "amino acid residues" RELATED [ChEBI] synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC] synonym: "amino-acid residues" RELATED [JCBN] is_a: CHEBI:33247 ! organic group relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue relationship: is_substituent_group_from CHEBI:33709 ! amino acid [Term] id: CHEBI:33709 name: amino acid namespace: chebi_ontology alt_id: CHEBI:13815 alt_id: CHEBI:22477 def: "A carboxylic acid containing one or more amino groups." [] subset: 3_STAR synonym: "amino acids" RELATED [ChEBI] synonym: "Aminocarbonsaeure" RELATED [ChEBI] synonym: "Aminokarbonsaeure" RELATED [ChEBI] synonym: "Aminosaeure" RELATED [ChEBI] xref: Wikipedia:Amino_acid is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation [Term] id: CHEBI:33710 name: alpha-amino-acid residue namespace: chebi_ontology def: "An amino-acid residue derived from an alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino-acid residues" RELATED [ChEBI] synonym: "an alpha-amino acid residue" RELATED [UniProt] is_a: CHEBI:33708 ! amino-acid residue relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33719 name: alpha-amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "alpha-amino acid cation" RELATED [ChEBI] synonym: "alpha-amino acid cations" RELATED [ChEBI] synonym: "alpha-amino-acid cations" RELATED [ChEBI] is_a: CHEBI:33703 ! amino-acid cation relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33720 name: carbohydrate acid namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate acid" EXACT [ChEBI] synonym: "carbohydrate acids" RELATED [ChEBI] is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:33721 ! carbohydrate acid anion [Term] id: CHEBI:33721 name: carbohydrate acid anion namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate acid anion" EXACT [ChEBI] synonym: "carbohydrate acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:33720 ! carbohydrate acid [Term] id: CHEBI:33791 name: canonical nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleoside residues" RELATED [ChEBI] synonym: "common nucleoside residues" RELATED [CBN] synonym: "nucleoside residue" RELATED [CBN] synonym: "standard nucleoside residues" RELATED [ChEBI] is_a: CHEBI:50320 ! nucleoside residue [Term] id: CHEBI:33792 name: canonical ribonucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleoside residues" RELATED [ChEBI] synonym: "common ribonucleoside residue" RELATED [CBN] synonym: "common ribonucleoside residues" RELATED [CBN] synonym: "N" RELATED [CBN] synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology alt_id: CHEBI:64710 def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] subset: 3_STAR synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organic alcohol" RELATED [ChEBI] synonym: "organic hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound namespace: chebi_ontology def: "Any organic molecule that consists of atoms connected in the form of a ring." [] subset: 3_STAR synonym: "organic cyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33833 name: heteroarene namespace: chebi_ontology def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." [] subset: 3_STAR synonym: "hetarenes" RELATED [IUPAC] synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33837 name: conjugated protein namespace: chebi_ontology def: "Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion." [] subset: 3_STAR synonym: "complex protein" RELATED [COMe] synonym: "conjugated proteins" EXACT IUPAC_NAME [IUPAC] xref: COMe:PRX000001 is_a: CHEBI:36080 ! protein [Term] id: CHEBI:33839 name: macromolecule namespace: chebi_ontology def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [] subset: 3_STAR synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC] synonym: "macromolecules" RELATED [ChEBI] synonym: "polymer" RELATED [ChEBI] synonym: "polymer molecule" RELATED [IUPAC] synonym: "polymers" RELATED [ChEBI] xref: Wikipedia:Macromolecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:33853 name: phenols namespace: chebi_ontology alt_id: CHEBI:13664 alt_id: CHEBI:13825 alt_id: CHEBI:25969 alt_id: CHEBI:2857 def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." [] subset: 3_STAR synonym: "a phenol" RELATED [UniProt] synonym: "arenols" RELATED [IUPAC] synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND] synonym: "phenols" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C15584 xref: MetaCyc:Phenols xref: Wikipedia:Phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:33893 name: reagent namespace: chebi_ontology def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." [] subset: 3_STAR synonym: "reactif" RELATED [IUPAC] synonym: "reactivo" RELATED [IUPAC] synonym: "reagent" EXACT IUPAC_NAME [IUPAC] synonym: "reagents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:33917 name: aldohexose namespace: chebi_ontology alt_id: CHEBI:2558 def: "A hexose with a (potential) aldehyde group at one end." [] subset: 3_STAR synonym: "aldohexose" EXACT [ChEBI] synonym: "aldohexoses" RELATED [ChEBI] is_a: CHEBI:15693 ! aldose is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:33937 name: macronutrient namespace: chebi_ontology def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." [] subset: 3_STAR synonym: "macronutrients" RELATED [ChEBI] is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:350546 name: serotonin(1+) namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3." [] subset: 3_STAR synonym: "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "serotonin" RELATED [UniProt] synonym: "serotonin cation" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28790 ! serotonin relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:35106 name: nitrogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen hydrides" RELATED [ChEBI] is_a: CHEBI:35881 ! pnictogen hydride is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35107 name: azane namespace: chebi_ontology def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." [] subset: 3_STAR synonym: "azanes" RELATED [ChEBI] is_a: CHEBI:35106 ! nitrogen hydride [Term] id: CHEBI:35222 name: inhibitor namespace: chebi_ontology def: "A substance that diminishes the rate of a chemical reaction." [] subset: 3_STAR synonym: "inhibidor" RELATED [ChEBI] synonym: "inhibiteur" RELATED [ChEBI] synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "inhibitors" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35223 name: catalyst namespace: chebi_ontology def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." [] subset: 3_STAR synonym: "catalizador" RELATED [ChEBI] synonym: "catalyseur" RELATED [ChEBI] synonym: "catalyst" EXACT IUPAC_NAME [IUPAC] synonym: "Katalysator" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:35238 name: amino-acid zwitterion namespace: chebi_ontology def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." [] subset: 3_STAR synonym: "amino acid zwitterion" RELATED [ChEBI] synonym: "amino acid zwitterions" RELATED [ChEBI] synonym: "amino-acid zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35267 name: quaternary ammonium ion namespace: chebi_ontology alt_id: CHEBI:26470 alt_id: CHEBI:8693 def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." [] subset: 3_STAR synonym: "a quaternary ammonium" RELATED [UniProt] synonym: "Quaternary amine" RELATED [KEGG_COMPOUND] synonym: "quaternary ammonium ion" EXACT IUPAC_NAME [IUPAC] synonym: "quaternary ammonium ions" RELATED [ChEBI] xref: KEGG:C06703 is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative [Term] id: CHEBI:35274 name: ammonium ion derivative namespace: chebi_ontology def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." [] subset: 3_STAR synonym: "ammonium ion derivatives" RELATED [ChEBI] synonym: "azanium ion derivative" RELATED [ChEBI] synonym: "azanium ion derivatives" RELATED [ChEBI] is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_parent_hydride CHEBI:28938 ! ammonium [Term] id: CHEBI:35287 name: acylcholine namespace: chebi_ontology alt_id: CHEBI:13245 alt_id: CHEBI:22227 alt_id: CHEBI:2463 def: "A choline ester formed from choline and a carboxylic acid." [] subset: 3_STAR synonym: "acylcholines" RELATED [ChEBI] synonym: "an acylcholine" RELATED [UniProt] xref: KEGG:C01777 is_a: CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:35341 name: steroid namespace: chebi_ontology alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." [] subset: 3_STAR synonym: "a steroid" RELATED [UniProt] synonym: "Steroid" EXACT [KEGG_COMPOUND] synonym: "steroids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00377 xref: MetaCyc:Steroids is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:35350 name: hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:24748 alt_id: CHEBI:5814 subset: 3_STAR synonym: "hydroxy steroids" RELATED [ChEBI] synonym: "Hydroxysteroid" RELATED [KEGG_COMPOUND] synonym: "hydroxysteroids" RELATED [ChEBI] xref: KEGG:C02159 is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:35352 name: organonitrogen compound namespace: chebi_ontology def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [] subset: 3_STAR synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organonitrogens" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35381 name: monosaccharide namespace: chebi_ontology alt_id: CHEBI:25407 alt_id: CHEBI:6984 def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." [] subset: 3_STAR synonym: "monosacarido" RELATED [ChEBI] synonym: "monosacaridos" RELATED [IUPAC] synonym: "Monosaccharid" RELATED [ChEBI] synonym: "Monosaccharide" EXACT [KEGG_COMPOUND] synonym: "monosaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Monosacharid" RELATED [ChEBI] xref: KEGG:C06698 is_a: CHEBI:16646 ! carbohydrate [Term] id: CHEBI:35406 name: oxoanion namespace: chebi_ontology alt_id: CHEBI:33274 alt_id: CHEBI:33436 def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." [] subset: 3_STAR synonym: "oxoacid anions" RELATED [ChEBI] synonym: "oxoanion" EXACT [ChEBI] synonym: "oxoanions" RELATED [ChEBI] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion [Term] id: CHEBI:35472 name: anti-inflammatory drug namespace: chebi_ontology def: "A substance that reduces or suppresses inflammation." [] subset: 3_STAR synonym: "anti-inflammatory drugs" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory drug" RELATED [ChEBI] synonym: "antiinflammatory drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:67079 ! anti-inflammatory agent [Term] id: CHEBI:35479 name: alkali metal salt namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal salts" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity [Term] id: CHEBI:35507 name: natural product fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "natural product fundamental parents" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35508 name: steroid fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "steroid fundamental parents" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:35507 ! natural product fundamental parent [Term] id: CHEBI:35519 name: cholane namespace: chebi_ontology subset: 3_STAR synonym: "cholane" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35508 ! steroid fundamental parent [Term] id: CHEBI:35524 name: sympathomimetic agent namespace: chebi_ontology def: "A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." [] subset: 3_STAR synonym: "sympathomimetic" RELATED [ChEBI] synonym: "sympathomimetics" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:35554 name: cardiovascular drug namespace: chebi_ontology def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." [] subset: 3_STAR synonym: "cardiovascular agent" RELATED [ChEBI] synonym: "cardiovascular drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35569 name: alpha-adrenergic agonist namespace: chebi_ontology def: "An agent that selectively binds to and activates alpha-adrenergic receptors." [] subset: 3_STAR synonym: "alpha-adrenergic agonists" RELATED [ChEBI] synonym: "alpha-adrenergic receptor agonist" RELATED [ChEBI] synonym: "alpha-adrenoceptor agonists" RELATED [IUPHAR] is_a: CHEBI:37886 ! adrenergic agonist is_a: CHEBI:48539 ! alpha-adrenergic drug [Term] id: CHEBI:35604 name: carbon oxoanion namespace: chebi_ontology def: "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." [] subset: 3_STAR synonym: "carbon oxoanion" EXACT [ChEBI] synonym: "carbon oxoanions" RELATED [ChEBI] synonym: "oxocarbon anion" RELATED [ChEBI] synonym: "oxocarbon anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35605 name: carbon oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "carbon oxoacids" RELATED [ChEBI] synonym: "oxoacids of carbon" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35620 name: vasodilator agent namespace: chebi_ontology def: "A drug used to cause dilation of the blood vessels." [] subset: 3_STAR synonym: "vasodilator" RELATED [ChEBI] synonym: "vasodilator agents" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35692 name: dicarboxylic acid namespace: chebi_ontology alt_id: CHEBI:23692 alt_id: CHEBI:36172 alt_id: CHEBI:4501 def: "Any carboxylic acid containing two carboxy groups." [] subset: 3_STAR synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND] synonym: "dicarboxylic acids" RELATED [ChEBI] xref: KEGG:C02028 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35693 name: dicarboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "dicarboxylic acid anion" EXACT [ChEBI] synonym: "dicarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid [Term] id: CHEBI:35701 name: ester namespace: chebi_ontology alt_id: CHEBI:23960 alt_id: CHEBI:4859 def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." [] subset: 3_STAR synonym: "Ester" EXACT [KEGG_COMPOUND] synonym: "esters" RELATED [ChEBI] xref: KEGG:C00287 xref: Wikipedia:Ester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35722 name: sulfated glycosaminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "glycosaminoglycan sulfate" RELATED [ChEBI] synonym: "glycosaminoglycan sulfates" RELATED [ChEBI] synonym: "sulfated glycosaminoglycans" RELATED [ChEBI] is_a: CHEBI:18085 ! glycosaminoglycan is_a: CHEBI:35724 ! carbohydrate sulfate [Term] id: CHEBI:35724 name: carbohydrate sulfate namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate sulfates" RELATED [ChEBI] synonym: "carbohydrate sulphates" RELATED [ChEBI] is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:35757 name: monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13657 alt_id: CHEBI:25382 alt_id: CHEBI:3407 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a monocarboxylate" RELATED [UniProt] synonym: "Carboxylate" RELATED [KEGG_COMPOUND] synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND] synonym: "monocarboxylates" RELATED [ChEBI] synonym: "monocarboxylic acid anions" RELATED [ChEBI] xref: KEGG:C00060 is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid [Term] id: CHEBI:35881 name: pnictogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen hydride" EXACT [ChEBI] synonym: "pnictogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:35942 name: neurotransmitter agent namespace: chebi_ontology def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." [] subset: 3_STAR synonym: "neurotransmitter agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:36078 name: cholanoid namespace: chebi_ontology alt_id: CHEBI:22867 alt_id: CHEBI:50419 subset: 3_STAR synonym: "bile acids and derivatives" RELATED [LIPID_MAPS] synonym: "cholanoids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMST04 {source="LIPID MAPS"} is_a: CHEBI:35341 ! steroid relationship: has_parent_hydride CHEBI:35519 ! cholane [Term] id: CHEBI:36080 name: protein namespace: chebi_ontology alt_id: CHEBI:13677 alt_id: CHEBI:14911 def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." [] subset: 3_STAR synonym: "proteins" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33695 ! information biomacromolecule relationship: has_part CHEBI:16541 ! protein polypeptide chain [Term] id: CHEBI:36235 name: bile acid anion namespace: chebi_ontology subset: 3_STAR synonym: "bile acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:36237 name: cholanic acid namespace: chebi_ontology def: "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." [] subset: 3_STAR synonym: "cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:25312-65-6 {source="ChemIDplus"} xref: Patent:JP2008069152 xref: Reaxys:13246008 {source="Reaxys"} is_a: CHEBI:36278 ! cholanic acids [Term] id: CHEBI:36238 name: 5beta-cholanic acid namespace: chebi_ontology subset: 3_STAR synonym: "(5beta)-cholan-24-oic acid" RELATED [ChemIDplus] synonym: "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" RELATED [ChemIDplus] synonym: "5beta-cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] synonym: "5beta-cholanic acid" EXACT [ChemIDplus] synonym: "5beta-cholanoic acid" RELATED [ChemIDplus] synonym: "ursocholanic acid" RELATED [ChemIDplus] xref: Beilstein:3214794 {source="Beilstein"} xref: CAS:546-18-9 {source="ChemIDplus"} xref: LIPID_MAPS_instance:LMST04010441 {source="LIPID MAPS"} is_a: CHEBI:36237 ! cholanic acid is_a: CHEBI:36248 ! 5beta-cholanic acids [Term] id: CHEBI:36248 name: 5beta-cholanic acids namespace: chebi_ontology def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." [] subset: 3_STAR is_a: CHEBI:136889 ! 5beta steroid is_a: CHEBI:36278 ! cholanic acids relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane [Term] id: CHEBI:36277 name: bile acid salt namespace: chebi_ontology def: "A salt of a bile acid." [] subset: 3_STAR synonym: "bile acid salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:36078 ! cholanoid [Term] id: CHEBI:36278 name: cholanic acids namespace: chebi_ontology alt_id: CHEBI:23166 alt_id: CHEBI:23211 subset: 1_STAR is_a: CHEBI:36078 ! cholanoid is_a: CHEBI:47891 ! steroid acid [Term] id: CHEBI:36338 name: lepton namespace: chebi_ontology def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." [] subset: 3_STAR synonym: "leptons" RELATED [ChEBI] is_a: CHEBI:33233 ! fundamental particle is_a: CHEBI:36340 ! fermion [Term] id: CHEBI:36339 name: baryon namespace: chebi_ontology def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." [] subset: 3_STAR synonym: "baryons" RELATED [ChEBI] is_a: CHEBI:36340 ! fermion is_a: CHEBI:36344 ! hadron [Term] id: CHEBI:36340 name: fermion namespace: chebi_ontology def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." [] subset: 3_STAR synonym: "fermion" EXACT IUPAC_NAME [IUPAC] synonym: "fermions" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36341 name: boson namespace: chebi_ontology def: "Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose." [] subset: 3_STAR synonym: "boson" EXACT IUPAC_NAME [IUPAC] synonym: "bosons" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36342 name: subatomic particle namespace: chebi_ontology def: "A particle smaller than an atom." [] subset: 3_STAR synonym: "subatomic particles" RELATED [ChEBI] xref: Wikipedia:Subatomic_particle [Term] id: CHEBI:36343 name: composite particle namespace: chebi_ontology def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." [] subset: 3_STAR synonym: "composite particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36344 name: hadron namespace: chebi_ontology def: "Hadron is a subatomic particle which experiences the strong force." [] subset: 3_STAR synonym: "hadrons" RELATED [ChEBI] is_a: CHEBI:36343 ! composite particle [Term] id: CHEBI:36347 name: nuclear particle namespace: chebi_ontology def: "A nucleus or any of its constituents in any of their energy states." [] subset: 3_STAR synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:24433 ! group [Term] id: CHEBI:36358 name: polyatomic ion namespace: chebi_ontology def: "An ion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:36586 name: carbonyl compound namespace: chebi_ontology def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." [] subset: 3_STAR synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23019 ! carbonyl group [Term] id: CHEBI:36587 name: organic oxo compound namespace: chebi_ontology def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." [] subset: 3_STAR synonym: "organic oxo compounds" RELATED [ChEBI] synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:72695 ! organic molecule relationship: has_part CHEBI:46629 ! oxo group [Term] id: CHEBI:36735 name: biladienes namespace: chebi_ontology def: "Compounds based on a biladiene skeleton." [] subset: 3_STAR is_a: CHEBI:25046 ! linear tetrapyrrole [Term] id: CHEBI:36902 name: chalcogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen hydride" EXACT [ChEBI] synonym: "chalcogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36914 name: inorganic ion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic ions" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36915 name: inorganic cation namespace: chebi_ontology subset: 3_STAR synonym: "inorganic cations" RELATED [ChEBI] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:36916 name: cation namespace: chebi_ontology alt_id: CHEBI:23058 alt_id: CHEBI:3473 def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." [] subset: 3_STAR synonym: "Cation" EXACT [KEGG_COMPOUND] synonym: "cation" EXACT IUPAC_NAME [IUPAC] synonym: "cation" EXACT [ChEBI] synonym: "cationes" RELATED [ChEBI] synonym: "cations" RELATED [ChEBI] synonym: "Kation" RELATED [ChEBI] synonym: "Kationen" RELATED [ChEBI] xref: KEGG:C01373 is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36961 name: chalcocarbonic acid namespace: chebi_ontology subset: 3_STAR synonym: "chalcocarbonic acid" EXACT [ChEBI] synonym: "chalcocarbonic acids" EXACT IUPAC_NAME [IUPAC] synonym: "chalcocarbonic acids" RELATED [ChEBI] is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36962 name: organochalcogen compound namespace: chebi_ontology def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." [] subset: 3_STAR synonym: "organochalcogen compound" EXACT [ChEBI] synonym: "organochalcogen compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36963 name: organooxygen compound namespace: chebi_ontology def: "An organochalcogen compound containing at least one carbon-oxygen bond." [] subset: 3_STAR synonym: "organooxygen compound" EXACT [ChEBI] synonym: "organooxygen compounds" RELATED [ChEBI] xref: PMID:17586126 {source="Europe PMC"} is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:37022 name: amino-acid anion namespace: chebi_ontology subset: 3_STAR synonym: "amino acid anion" RELATED [ChEBI] synonym: "amino acid anions" RELATED [ChEBI] synonym: "amino-acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound relationship: is_conjugate_base_of CHEBI:33709 ! amino acid [Term] id: CHEBI:37163 name: glucan namespace: chebi_ontology alt_id: CHEBI:24255 alt_id: CHEBI:5392 def: "A polysaccharide composed of glucose residues." [] subset: 3_STAR synonym: "Glucan" EXACT [KEGG_COMPOUND] synonym: "glucan" EXACT IUPAC_NAME [IUPAC] synonym: "glucans" RELATED [ChEBI] xref: CAS:9037-91-6 {source="ChemIDplus"} xref: KEGG:C01379 is_a: CHEBI:37164 ! homopolysaccharide [Term] id: CHEBI:37164 name: homopolysaccharide namespace: chebi_ontology def: "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." [] subset: 3_STAR synonym: "homoglycan" RELATED [IUPAC] synonym: "homopolysaccharide" EXACT IUPAC_NAME [IUPAC] synonym: "homopolysaccharides" RELATED [ChEBI] is_a: CHEBI:18154 ! polysaccharide [Term] id: CHEBI:37175 name: organic hydride namespace: chebi_ontology subset: 3_STAR synonym: "organic hydrides" RELATED [ChEBI] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37176 name: mononuclear parent hydride namespace: chebi_ontology subset: 3_STAR synonym: "mononuclear hydride" RELATED [ChEBI] synonym: "mononuclear hydrides" RELATED [IUPAC] synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37246 name: elemental sodium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26712 ! sodium molecular entity [Term] id: CHEBI:37395 name: mucopolysaccharide namespace: chebi_ontology alt_id: CHEBI:25425 alt_id: CHEBI:7011 def: "Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid." [] subset: 3_STAR synonym: "mucopolisacarido" RELATED [ChEBI] synonym: "mucopolisacaridos" RELATED [IUPAC] synonym: "Mucopolysaccharid" RELATED [ChEBI] synonym: "Mucopolysaccharide" EXACT [KEGG_COMPOUND] synonym: "mucopolysaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Mukopolysaccharid" RELATED [ChEBI] xref: KEGG:C05114 is_a: CHEBI:18085 ! glycosaminoglycan [Term] id: CHEBI:37527 name: acid namespace: chebi_ontology alt_id: CHEBI:13800 alt_id: CHEBI:13801 alt_id: CHEBI:22209 alt_id: CHEBI:2426 def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." [] subset: 3_STAR synonym: "Acid" EXACT [KEGG_COMPOUND] synonym: "acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide" RELATED [IUPAC] synonym: "acido" RELATED [ChEBI] synonym: "acids" RELATED [ChEBI] synonym: "Saeure" RELATED [ChEBI] synonym: "Saeuren" RELATED [ChEBI] xref: KEGG:C00174 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] subset: 3_STAR synonym: "chemical compound" RELATED [ChEBI] synonym: "heteroatomic molecular entities" RELATED [ChEBI] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:37622 name: carboxamide namespace: chebi_ontology alt_id: CHEBI:35354 alt_id: CHEBI:35355 def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC] synonym: "carboxamides" RELATED [ChEBI] synonym: "primary carboxamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23004 ! carbamoyl group [Term] id: CHEBI:37661 name: glucopyranose namespace: chebi_ontology subset: 3_STAR synonym: "glucopyranose" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:17234 ! glucose [Term] id: CHEBI:37826 name: sulfuric acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfuric acid derivative" EXACT [ChEBI] synonym: "sulfuric acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:37838 name: carboacyl group namespace: chebi_ontology def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "carboacyl groups" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl group" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl groups" RELATED [IUPAC] is_a: CHEBI:22221 ! acyl group relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:37886 name: adrenergic agonist namespace: chebi_ontology def: "An agent that selectively binds to and activates adrenergic receptors." [] subset: 3_STAR synonym: "adrenergic agonists" RELATED [ChEBI] synonym: "adrenergic receptor agonist" RELATED [ChEBI] synonym: "adrenoceptor agonists" RELATED [IUPHAR] synonym: "adrenomimetic" RELATED [ChEBI] synonym: "adrenomimetics" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:37962 name: adrenergic agent namespace: chebi_ontology def: "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter." [] subset: 3_STAR synonym: "adrenergic agents" RELATED [ChEBI] synonym: "adrenergic drug" RELATED [ChEBI] synonym: "adrenergic drugs" RELATED [ChEBI] synonym: "adrenergic neuron agents" RELATED [ChEBI] synonym: "adrenergics" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:38077 name: polypyrrole namespace: chebi_ontology def: "A compound composed of two or more pyrrole units." [] subset: 3_STAR synonym: "poly(pyrrole)s" RELATED [ChEBI] synonym: "polypyrroles" RELATED [ChEBI] synonym: "PPys" RELATED [ChEBI] xref: Beilstein:8538310 {source="Beilstein"} is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound namespace: chebi_ontology def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." [] subset: 3_STAR synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI] synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38166 name: organic heteropolycyclic compound namespace: chebi_ontology alt_id: CHEBI:25429 alt_id: CHEBI:38075 subset: 3_STAR synonym: "organic heteropolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:38180 name: polycyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38323 name: cholinergic drug namespace: chebi_ontology def: "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." [] subset: 3_STAR synonym: "cholinergic agent" RELATED [ChEBI] synonym: "cholinergic drugs" RELATED [ChEBI] synonym: "cholinomimetic" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:38324 name: cholinergic agonist namespace: chebi_ontology def: "Any drug that binds to and activates cholinergic receptors." [] subset: 3_STAR synonym: "acetylcholine agonist" RELATED [ChEBI] synonym: "acetylcholine agonists" RELATED [ChEBI] synonym: "acetylcholine receptor agonist" RELATED [IUPHAR] synonym: "cholinergic agonists" RELATED [ChEBI] synonym: "cholinomimetic" RELATED [ChEBI] synonym: "cholinomimetics" RELATED [ChEBI] is_a: CHEBI:38323 ! cholinergic drug [Term] id: CHEBI:38325 name: muscarinic agonist namespace: chebi_ontology def: "Any drug that binds to and activates a muscarinic cholinergic receptor." [] subset: 3_STAR synonym: "muscarinic acetylcholine receptor agonist" RELATED [ChEBI] synonym: "muscarinic agonists" RELATED [ChEBI] synonym: "muscarinic cholinergic agonist" RELATED [ChEBI] synonym: "muscarinic cholinergic agonists" RELATED [ChEBI] is_a: CHEBI:38324 ! cholinergic agonist [Term] id: CHEBI:38631 name: aminoalkylindole namespace: chebi_ontology alt_id: CHEBI:22503 alt_id: CHEBI:24792 subset: 3_STAR synonym: "aminoalkylindoles" RELATED [ChEBI] is_a: CHEBI:24828 ! indoles [Term] id: CHEBI:38700 name: organic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sodium salt" EXACT [ChEBI] synonym: "organic sodium salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38716 name: carboxylic acid dianion namespace: chebi_ontology def: "Any dianion containing at least one carboxy group." [] subset: 3_STAR synonym: "carboxylic acid dianion" EXACT [ChEBI] synonym: "carboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:38958 name: indole alkaloid namespace: chebi_ontology alt_id: CHEBI:24795 alt_id: CHEBI:5901 def: "An alkaloid containing an indole skeleton." [] subset: 3_STAR synonym: "Indole alkaloid" EXACT [KEGG_COMPOUND] synonym: "indole alkaloids" RELATED [ChEBI] xref: KEGG:C06073 xref: Wikipedia:Indole_alkaloid is_a: CHEBI:22315 ! alkaloid relationship: has_part CHEBI:73398 ! indole skeleton [Term] id: CHEBI:39141 name: Bronsted acid namespace: chebi_ontology def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." [] subset: 3_STAR synonym: "acide de Bronsted" RELATED [IUPAC] synonym: "Bronsted acid" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Saeure" RELATED [ChEBI] synonym: "donneur d'hydron" RELATED [IUPAC] synonym: "hydron donor" RELATED [IUPAC] is_a: CHEBI:17891 ! donor is_a: CHEBI:37527 ! acid [Term] id: CHEBI:39142 name: Bronsted base namespace: chebi_ontology def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." [] subset: 3_STAR synonym: "accepteur d'hydron" RELATED [IUPAC] synonym: "base de Bronsted" RELATED [IUPAC] synonym: "Bronsted base" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Base" RELATED [ChEBI] synonym: "hydron acceptor" RELATED [IUPAC] is_a: CHEBI:15339 ! acceptor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39144 name: Lewis base namespace: chebi_ontology def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." [] subset: 3_STAR synonym: "base de Lewis" RELATED [IUPAC] synonym: "donneur d'une paire d'electrons" RELATED [ChEBI] synonym: "electron donor" RELATED [ChEBI] synonym: "Lewis base" EXACT IUPAC_NAME [IUPAC] synonym: "Lewis-Base" RELATED [ChEBI] is_a: CHEBI:17891 ! donor is_a: CHEBI:22695 ! base [Term] id: CHEBI:41609 name: carbonate namespace: chebi_ontology alt_id: CHEBI:29201 alt_id: CHEBI:41605 subset: 3_STAR synonym: "[CO3](2-)" RELATED [IUPAC] synonym: "carbonate" EXACT [IUPAC] synonym: "CARBONATE ION" RELATED [PDBeChem] synonym: "CO3(2-)" RELATED [ChEBI] synonym: "Karbonat" RELATED [ChEBI] synonym: "trioxidocarbonate(2-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3600898 {source="Beilstein"} xref: CAS:3812-32-6 {source="ChemIDplus"} xref: Gmelin:1559 {source="Gmelin"} xref: PDBeChem:CO3 is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate [Term] id: CHEBI:4167 name: D-glucopyranose namespace: chebi_ontology def: "A glucopyranose having D-configuration." [] subset: 3_STAR synonym: "D-Glc" RELATED [ChEBI] synonym: "D-Glcp" RELATED [ChEBI] synonym: "D-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Glucose" RELATED [KEGG_COMPOUND] synonym: "D-glucose" RELATED [UniProt] synonym: "Dextrose" RELATED [KEGG_COMPOUND] synonym: "Glc-OH" RELATED [ChEBI] synonym: "Glucose" RELATED [KEGG_COMPOUND] synonym: "glucose" RELATED [ChEBI] synonym: "Grape sugar" RELATED [KEGG_COMPOUND] synonym: "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" RELATED [GlyTouCan] xref: CAS:2280-44-6 {source="ChemIDplus"} xref: GlyGen:G15021LG xref: GlyTouCan:G15021LG xref: Gmelin:83256 {source="Gmelin"} xref: HMDB:HMDB0000122 xref: KEGG:C00031 xref: KEGG:D00009 xref: KNApSAcK:C00001122 xref: MetaCyc:D-Glucose xref: PMID:15987845 {source="Europe PMC"} xref: PMID:16901854 {source="Europe PMC"} xref: PMID:17336832 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17928662 {source="Europe PMC"} xref: PMID:19913595 {source="Europe PMC"} xref: PMID:26812026 {source="Europe PMC"} xref: PMID:32619908 {source="Europe PMC"} xref: PMID:7524207 {source="Europe PMC"} xref: PMID:9140037 {source="Europe PMC"} xref: PMID:9501190 {source="Europe PMC"} xref: PMID:9506998 {source="Europe PMC"} xref: PMID:9545565 {source="Europe PMC"} xref: Reaxys:1281604 {source="Reaxys"} xref: Wikipedia:Glucose is_a: CHEBI:17634 ! D-glucose is_a: CHEBI:37661 ! glucopyranose relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:4194 name: D-hexose namespace: chebi_ontology def: "A hexose that has D-configuration at position 5." [] subset: 3_STAR synonym: "a D-hexose" RELATED [UniProt] synonym: "D-hexopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Hexose" EXACT [KEGG_COMPOUND] synonym: "D-hexoses" RELATED [ChEBI] xref: KEGG:C00738 is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:43176 name: hydroxy group namespace: chebi_ontology alt_id: CHEBI:24706 alt_id: CHEBI:43171 subset: 3_STAR synonym: "-OH" RELATED [IUPAC] synonym: "hydroxy" EXACT IUPAC_NAME [IUPAC] synonym: "HYDROXY GROUP" EXACT [PDBeChem] synonym: "hydroxy group" EXACT [UniProt] synonym: "hydroxyl" RELATED [ChEBI] synonym: "hydroxyl group" RELATED [ChEBI] xref: PDBeChem:OH is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:45696 name: hydrogensulfate namespace: chebi_ontology alt_id: CHEBI:29199 alt_id: CHEBI:45693 subset: 3_STAR synonym: "[SO3(OH)](-)" RELATED [IUPAC] synonym: "HSO4(-)" RELATED [IUPAC] synonym: "HYDROGEN SULFATE" RELATED [PDBeChem] synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogensulfate" EXACT [IUPAC] synonym: "hydrogensulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:2121 {source="Gmelin"} is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:46629 name: oxo group namespace: chebi_ontology alt_id: CHEBI:29353 alt_id: CHEBI:44607 subset: 3_STAR synonym: "=O" RELATED [IUPAC] synonym: "oxo" EXACT IUPAC_NAME [IUPAC] synonym: "OXO GROUP" EXACT [PDBeChem] xref: PDBeChem:O is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:46787 name: solvent namespace: chebi_ontology def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." [] subset: 3_STAR synonym: "Loesungsmittel" RELATED [ChEBI] synonym: "solvant" RELATED [ChEBI] synonym: "solvents" RELATED [ChEBI] xref: Wikipedia:Solvent is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:46883 name: carboxy group namespace: chebi_ontology alt_id: CHEBI:23025 alt_id: CHEBI:41420 subset: 3_STAR synonym: "-C(O)OH" RELATED [IUPAC] synonym: "-CO2H" RELATED [ChEBI] synonym: "-COOH" RELATED [IUPAC] synonym: "carboxy" EXACT IUPAC_NAME [IUPAC] synonym: "CARBOXY GROUP" EXACT [PDBeChem] synonym: "carboxyl group" RELATED [ChEBI] xref: PDBeChem:FMT is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:47622 name: acetate ester namespace: chebi_ontology alt_id: CHEBI:13244 alt_id: CHEBI:13799 alt_id: CHEBI:22189 alt_id: CHEBI:2406 def: "Any carboxylic ester where the carboxylic acid component is acetic acid." [] subset: 3_STAR synonym: "acetate" RELATED [ChEBI] synonym: "acetate esters" RELATED [ChEBI] synonym: "acetates" RELATED [ChEBI] synonym: "Acetic ester" RELATED [KEGG_COMPOUND] synonym: "Acetyl ester" RELATED [KEGG_COMPOUND] synonym: "acetyl esters" RELATED [ChEBI] synonym: "an acetyl ester" RELATED [UniProt] xref: KEGG:C01883 xref: Wikipedia:Acetate#Esters is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:15366 ! acetic acid [Term] id: CHEBI:47891 name: steroid acid namespace: chebi_ontology def: "Any steroid substituted by at least one carboxy group." [] subset: 3_STAR synonym: "steroid acids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:48154 name: sulfur oxide namespace: chebi_ontology subset: 3_STAR synonym: "oxides of sulfur" RELATED [ChEBI] synonym: "Schwefeloxide" RELATED [ChEBI] synonym: "sulfur oxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48354 name: polar solvent namespace: chebi_ontology def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." [] subset: 3_STAR synonym: "polar solvent" EXACT IUPAC_NAME [IUPAC] synonym: "polar solvents" RELATED [ChEBI] is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48356 name: protic solvent namespace: chebi_ontology def: "A polar solvent that is capable of acting as a hydron (proton) donor." [] subset: 3_STAR synonym: "protogenic solvent" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:39141 ! Bronsted acid is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48539 name: alpha-adrenergic drug namespace: chebi_ontology def: "Any drug that acts on an alpha-adrenergic receptor." [] subset: 3_STAR synonym: "alpha-adrenergic drugs" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:48705 name: agonist namespace: chebi_ontology def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." [] subset: 3_STAR synonym: "agonist" EXACT IUPAC_NAME [IUPAC] synonym: "agonista" RELATED [ChEBI] synonym: "agoniste" RELATED [ChEBI] synonym: "agonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:49637 name: hydrogen atom namespace: chebi_ontology alt_id: CHEBI:24634 alt_id: CHEBI:49636 subset: 3_STAR synonym: "1H" RELATED [IUPAC] synonym: "H" RELATED [IUPAC] synonym: "hidrogeno" RELATED [ChEBI] synonym: "hydrogen" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen" RELATED [ChEBI] synonym: "hydrogene" RELATED [ChEBI] synonym: "Wasserstoff" RELATED [ChEBI] xref: WebElements:H is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33559 ! s-block element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:50047 name: organic amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "organic amino compounds" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base [Term] id: CHEBI:50160 name: steroid acid anion namespace: chebi_ontology def: "Any anion formed by loss of a proton from a steroid acid." [] subset: 3_STAR synonym: "steroid acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid [Term] id: CHEBI:50297 name: canonical nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:50299 name: canonical ribonucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:50312 name: onium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:50313 name: onium cation namespace: chebi_ontology def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." [] subset: 3_STAR synonym: "onium cations" EXACT IUPAC_NAME [IUPAC] synonym: "onium cations" RELATED [ChEBI] synonym: "onium ion" RELATED [ChEBI] synonym: "onium ions" RELATED [ChEBI] is_a: CHEBI:50312 ! onium compound [Term] id: CHEBI:50319 name: nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleotide residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50320 name: nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleoside residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50514 name: vasoconstrictor agent namespace: chebi_ontology def: "Drug used to cause constriction of the blood vessels." [] subset: 3_STAR is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] subset: 3_STAR synonym: "organic compounds" RELATED [ChEBI] synonym: "organic entity" RELATED [ChEBI] synonym: "organic molecular entities" RELATED [ChEBI] is_a: CHEBI:33582 ! carbon group molecular entity relationship: has_part CHEBI:27594 ! carbon atom [Term] id: CHEBI:50906 name: role namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] subset: 3_STAR [Term] id: CHEBI:50910 name: neurotoxin namespace: chebi_ontology alt_id: CHEBI:50911 def: "A poison that interferes with the functions of the nervous system." [] subset: 3_STAR synonym: "agente neurotoxico" RELATED [ChEBI] synonym: "nerve poison" RELATED [ChEBI] synonym: "nerve poisons" RELATED [ChEBI] synonym: "neurotoxic agent" RELATED [ChEBI] synonym: "neurotoxic agents" RELATED [ChEBI] synonym: "neurotoxicant" RELATED [ChEBI] synonym: "neurotoxins" RELATED [ChEBI] xref: Wikipedia:Neurotoxin is_a: CHEBI:52209 ! aetiopathogenetic role is_a: CHEBI:64909 ! poison [Term] id: CHEBI:50994 name: primary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [] subset: 3_STAR synonym: "primary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion [Term] id: CHEBI:51086 name: chemical role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a chemical context." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:51143 name: nitrogen molecular entity namespace: chebi_ontology alt_id: CHEBI:25556 alt_id: CHEBI:7594 subset: 3_STAR synonym: "nitrogen compounds" RELATED [ChEBI] synonym: "nitrogen molecular entities" RELATED [ChEBI] synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND] xref: KEGG:C06061 is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:25555 ! nitrogen atom [Term] id: CHEBI:51151 name: dipolar compound namespace: chebi_ontology def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." [] subset: 3_STAR synonym: "dipolar compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:51422 name: organodiyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." [] subset: 3_STAR synonym: "organodiyl groups" RELATED [ChEBI] is_a: CHEBI:51446 ! organic divalent group [Term] id: CHEBI:51446 name: organic divalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51447 name: organic univalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51958 name: organic polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:52206 name: biochemical role namespace: chebi_ontology def: "A biological role played by the molecular entity or part thereof within a biochemical context." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52209 name: aetiopathogenetic role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." [] subset: 3_STAR synonym: "etiopathogenetic agent" RELATED [ChEBI] synonym: "etiopathogenetic role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52210 name: pharmacological role namespace: chebi_ontology def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52211 name: physiological role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52217 name: pharmaceutical namespace: chebi_ontology alt_id: CHEBI:33293 alt_id: CHEBI:33294 def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." [] subset: 3_STAR synonym: "farmaco" RELATED [ChEBI] synonym: "medicament" RELATED [ChEBI] synonym: "pharmaceuticals" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:52845 name: cyclic organic group namespace: chebi_ontology def: "An organic group that consists of a closed ring. It may be a substituent or a skeleton." [] subset: 3_STAR synonym: "cyclic organic groups" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:53000 name: epitope namespace: chebi_ontology def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." [] subset: 3_STAR synonym: "antigenic determinant" RELATED [ChEBI] synonym: "epitope function" RELATED [ChEBI] synonym: "epitope role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:53309 name: polyanionic macromolecule namespace: chebi_ontology def: "A polymer carrying multiple negative charges." [] subset: 3_STAR synonym: "polyanion" RELATED [ChEBI] synonym: "polyanions" RELATED [SUBMITTER] is_a: CHEBI:53368 ! ionic macromolecule [Term] id: CHEBI:53368 name: ionic macromolecule namespace: chebi_ontology def: "A macromolecule containing ionic groups." [] subset: 3_STAR synonym: "ionic polymer" RELATED [ChEBI] synonym: "polyionic macromolecule" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:5391 name: glucagon namespace: chebi_ontology def: "A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence." [] subset: 3_STAR synonym: "Glucagon" EXACT [KEGG_COMPOUND] synonym: "glucagon" RELATED INN [ChemIDplus] synonym: "Glucagone" RELATED [ChemIDplus] synonym: "glucagonum" RELATED INN [ChemIDplus] synonym: "His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr" RELATED [ChEBI] synonym: "His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr" RELATED [ChemIDplus] synonym: "HSQGTFTSDYSKYLDSRRAQDFVQWLMNT" RELATED [ChEBI] synonym: "L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine" EXACT IUPAC_NAME [IUPAC] xref: CAS:16941-32-5 {source="ChemIDplus"} xref: CAS:9007-92-5 {source="KEGG COMPOUND"} xref: CAS:9007-92-5 {source="ChemIDplus"} xref: Drug_Central:2994 {source="DrugCentral"} xref: DrugBank:DB00040 xref: KEGG:C01501 xref: KEGG:D00116 xref: PMID:21940356 {source="Europe PMC"} xref: PMID:22014161 {source="Europe PMC"} xref: PMID:22154917 {source="Europe PMC"} xref: PMID:22166985 {source="Europe PMC"} xref: PMID:22167521 {source="Europe PMC"} xref: PMID:22214853 {source="Europe PMC"} xref: PMID:22227186 {source="Europe PMC"} xref: PMID:22286080 {source="Europe PMC"} xref: PMID:22294753 {source="Europe PMC"} xref: PMID:22318544 {source="Europe PMC"} xref: PMID:22334714 {source="Europe PMC"} xref: PMID:22399501 {source="Europe PMC"} xref: PMID:22438981 {source="Europe PMC"} xref: PMID:22454291 {source="Europe PMC"} xref: Reaxys:13191924 {source="Reaxys"} xref: Wikipedia:Glucagon is_a: CHEBI:25905 ! peptide hormone [Term] id: CHEBI:5686 name: heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of at least two different elements." [] subset: 3_STAR synonym: "compuesto heterociclico" RELATED [IUPAC] synonym: "compuestos heterociclicos" RELATED [IUPAC] synonym: "heterocycle" RELATED [ChEBI] synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND] synonym: "heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:57887 name: tryptaminium namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "2-(1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "tryptamine" RELATED [UniProt] synonym: "tryptaminium cation" RELATED [ChEBI] synonym: "tryptaminium(1+)" RELATED [ChEBI] xref: Gmelin:533978 {source="Gmelin"} is_a: BFO:0000004 ! independent continuant is_a: CHEBI:65296 ! primary ammonium ion relationship: is_conjugate_acid_of CHEBI:16765 ! tryptamine relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:57977 name: bilirubin(2-) namespace: chebi_ontology def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." [] subset: 3_STAR synonym: "(4Z,15Z)-bilirubin IXalpha" RELATED [UniProt] synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate" RELATED [ChEBI] synonym: "bilirubin dianion" RELATED [ChEBI] xref: Beilstein:4083310 {source="Beilstein"} is_a: BFO:0000004 ! independent continuant is_a: CHEBI:28965 ! dicarboxylic acid dianion is_a: CHEBI:59252 ! linear tetrapyrrole anion relationship: is_conjugate_base_of CHEBI:16990 ! bilirubin IXalpha relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:58942 name: cationic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue protonated on nitrogen." [] subset: 3_STAR synonym: "amino acid cation residue" RELATED [ChEBI] synonym: "amino acid cation residues" RELATED [ChEBI] synonym: "amino-acid cation residue" RELATED [ChEBI] synonym: "amino-acid cation residues" RELATED [ChEBI] synonym: "cationic amino acid residue" RELATED [ChEBI] synonym: "cationic amino acid residues" RELATED [ChEBI] synonym: "cationic amino-acid residues" RELATED [ChEBI] is_a: CHEBI:64769 ! organic cationic group relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:58958 name: organosulfate oxoanion namespace: chebi_ontology def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." [] subset: 3_STAR synonym: "organosulfate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:33482 ! sulfur oxoanion relationship: has_functional_parent CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate [Term] id: CHEBI:59252 name: linear tetrapyrrole anion namespace: chebi_ontology def: "An organic anion arising from deprotonation of a acyclic tetrapyrrole compound." [] subset: 3_STAR synonym: "acyclic tetrapyrrole anion" RELATED [ChEBI] synonym: "acyclic tetrapyrrole anions" RELATED [ChEBI] synonym: "linear tetrapyrrole anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:59740 name: nucleophilic reagent namespace: chebi_ontology def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." [] subset: 3_STAR synonym: "nucleophile" RELATED [ChEBI] synonym: "nucleophiles" RELATED [ChEBI] synonym: "nucleophilic reagents" RELATED [ChEBI] is_a: CHEBI:33893 ! reagent is_a: CHEBI:39144 ! Lewis base [Term] id: CHEBI:59999 name: chemical substance namespace: chebi_ontology def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." [] subset: 3_STAR synonym: "Chemische Substanz" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:60004 name: mixture namespace: chebi_ontology def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." [] subset: 3_STAR synonym: "Mischung" RELATED [ChEBI] is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:60027 name: polymer namespace: chebi_ontology def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." [] subset: 3_STAR synonym: "Kunststoff" RELATED [ChEBI] synonym: "Polymer" EXACT [ChEBI] xref: Wikipedia:Polymer is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:33839 ! macromolecule [Term] id: CHEBI:60164 name: ionic polymer namespace: chebi_ontology def: "An ionic polymer is a polymer, composed of ionic macromolecules." [] subset: 3_STAR synonym: "polyionic polymer" RELATED [ChEBI] is_a: CHEBI:60027 ! polymer relationship: has_part CHEBI:53368 ! ionic macromolecule [Term] id: CHEBI:60242 name: monovalent inorganic cation namespace: chebi_ontology def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." [] subset: 3_STAR synonym: "a monovalent cation" RELATED [UniProt] is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:60466 name: peptide zwitterion namespace: chebi_ontology def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." [] subset: 3_STAR synonym: "a peptide" RELATED [UniProt] synonym: "peptide zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:16670 ! peptide [Term] id: CHEBI:61120 name: nucleobase-containing molecular entity namespace: chebi_ontology def: "Any compound that has a nucleobase as a part." [] subset: 3_STAR synonym: "nucleobase-containing compound" RELATED [SUBMITTER] synonym: "nucleobase-containing compounds" RELATED [ChEBI] synonym: "nucleobase-containing molecular entities" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_functional_parent CHEBI:18282 ! nucleobase [Term] id: CHEBI:61469 name: polyanionic polymer namespace: chebi_ontology def: "A polymer, composed of polyanion macromolecules." [] subset: 3_STAR synonym: "polyanion" RELATED [ChEBI] synonym: "polyanions" RELATED [ChEBI] is_a: CHEBI:60164 ! ionic polymer relationship: has_part CHEBI:53309 ! polyanionic macromolecule [Term] id: CHEBI:63248 name: oxidising agent namespace: chebi_ontology def: "A substance that removes electrons from another reactant in a redox reaction." [] subset: 3_STAR synonym: "oxidant" RELATED [ChEBI] synonym: "oxidants" RELATED [ChEBI] synonym: "oxidiser" RELATED [ChEBI] synonym: "oxidisers" RELATED [ChEBI] synonym: "oxidising agents" RELATED [ChEBI] synonym: "oxidizer" RELATED [ChEBI] synonym: "oxidizers" RELATED [ChEBI] synonym: "oxidizing agent" RELATED [ChEBI] synonym: "oxidizing agents" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63299 name: carbohydrate derivative namespace: chebi_ontology def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." [] subset: 3_STAR synonym: "carbohydrate derivatives" RELATED [ChEBI] synonym: "derivatised carbohydrate" RELATED [ChEBI] synonym: "derivatised carbohydrates" RELATED [ChEBI] synonym: "derivatized carbohydrate" RELATED [ChEBI] synonym: "derivatized carbohydrates" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives relationship: has_functional_parent CHEBI:16646 ! carbohydrate [Term] id: CHEBI:63436 name: carbohydrate acid derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a carbohydrate acid." [] subset: 3_STAR synonym: "carbohydrate acid derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:33720 ! carbohydrate acid relationship: is_conjugate_acid_of CHEBI:63551 ! carbohydrate acid derivative anion [Term] id: CHEBI:63534 name: monoamine namespace: chebi_ontology def: "An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes." [] subset: 3_STAR synonym: "monoamines" RELATED [ChEBI] synonym: "naturally occurring monoamine" RELATED [ChEBI] synonym: "naturally occurring monoamines" RELATED [ChEBI] xref: PMID:21822758 {source="Europe PMC"} xref: PMID:21993877 {source="Europe PMC"} xref: PMID:22005599 {source="Europe PMC"} xref: PMID:22082101 {source="Europe PMC"} xref: PMID:22153577 {source="Europe PMC"} xref: PMID:22213370 {source="Europe PMC"} xref: PMID:22218931 {source="Europe PMC"} xref: PMID:22342987 {source="Europe PMC"} xref: PMID:22371656 {source="Europe PMC"} is_a: CHEBI:64365 ! aralkylamino compound [Term] id: CHEBI:63551 name: carbohydrate acid derivative anion namespace: chebi_ontology def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." [] subset: 3_STAR synonym: "carbohydrate acid anion derivative" RELATED [ChEBI] synonym: "carbohydrate acid anion derivatives" RELATED [ChEBI] synonym: "carbohydrate acid derivative anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative [Term] id: CHEBI:64047 name: food additive namespace: chebi_ontology def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." [] subset: 3_STAR synonym: "food additives" RELATED [ChEBI] xref: Wikipedia:Food_additive is_a: CHEBI:33232 ! application is_a: CHEBI:78295 ! food component [Term] id: CHEBI:64049 name: food acidity regulator namespace: chebi_ontology def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." [] subset: 3_STAR synonym: "acidity regulator" RELATED [ChEBI] synonym: "acidity regulators" RELATED [ChEBI] synonym: "food acidity regulators" RELATED [ChEBI] synonym: "pH control agent" RELATED [ChEBI] synonym: "pH control agents" RELATED [ChEBI] xref: Wikipedia:Acidity_regulator is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64365 name: aralkylamino compound namespace: chebi_ontology def: "An organic amino compound in which an aminoalkyl group is linked to an arene." [] subset: 3_STAR synonym: "aralkylamino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:64628 name: somatostatin namespace: chebi_ontology def: "A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14." [] subset: 3_STAR synonym: "Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]" RELATED [ChEBI] synonym: "L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide" EXACT IUPAC_NAME [IUPAC] synonym: "L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide" RELATED [ChemIDplus] synonym: "somatostatin" RELATED INN [KEGG_DRUG] synonym: "Somatostatin-1" RELATED [KEGG_COMPOUND] synonym: "Somatostatin-14" RELATED [KEGG_COMPOUND] synonym: "somatostatina" RELATED INN [ChemIDplus] synonym: "somatostatine" RELATED INN [ChemIDplus] synonym: "somatostatinum" RELATED INN [ChemIDplus] synonym: "Synthetic growth hormone release-inhibiting hormone" RELATED [ChemIDplus] xref: CAS:38916-34-6 {source="KEGG DRUG"} xref: CAS:38916-34-6 {source="ChemIDplus"} xref: Drug_Central:2997 {source="DrugCentral"} xref: HMDB:HMDB0013072 xref: KEGG:C16022 xref: KEGG:D07431 xref: LINCS:LSM-5326 xref: PMID:21922516 {source="Europe PMC"} xref: PMID:22129035 {source="Europe PMC"} xref: PMID:22147011 {source="Europe PMC"} xref: PMID:22251942 {source="Europe PMC"} xref: PMID:22483686 {source="Europe PMC"} xref: PMID:22509294 {source="Europe PMC"} xref: Reaxys:10148626 {source="Reaxys"} xref: Wikipedia:Somatostatin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25905 ! peptide hormone [Term] id: CHEBI:64708 name: one-carbon compound namespace: chebi_ontology def: "An organic molecular entity containing a single carbon atom (C1)." [] subset: 3_STAR synonym: "one-carbon compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64709 name: organic acid namespace: chebi_ontology def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." [] subset: 3_STAR synonym: "organic acids" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64766 name: cationic group namespace: chebi_ontology def: "A group that carries an overall positive charge." [] subset: 3_STAR synonym: "cationic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64767 name: anionic group namespace: chebi_ontology def: "A group that carries an overall negative charge." [] subset: 3_STAR synonym: "anionic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64769 name: organic cationic group namespace: chebi_ontology def: "A cationic group that contains carbon." [] subset: 3_STAR synonym: "organic cationic groups" RELATED [ChEBI] is_a: CHEBI:64766 ! cationic group relationship: is_conjugate_acid_of CHEBI:33247 ! organic group [Term] id: CHEBI:64775 name: organic anionic group namespace: chebi_ontology def: "An anionic group that contains carbon." [] subset: 3_STAR synonym: "organic anionic groups" RELATED [ChEBI] is_a: CHEBI:64767 ! anionic group relationship: is_conjugate_base_of CHEBI:33247 ! organic group [Term] id: CHEBI:64898 name: anionic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue carrying an overall negative charge." [] subset: 3_STAR synonym: "amino acid anion residue" RELATED [ChEBI] synonym: "amino acid anion residues" RELATED [ChEBI] synonym: "amino-acid anion residue" RELATED [ChEBI] synonym: "amino-acid anion residues" RELATED [ChEBI] synonym: "anionic amino acid residue" RELATED [ChEBI] synonym: "anionic amino acid residues" RELATED [ChEBI] is_a: CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:64909 name: poison namespace: chebi_ontology def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." [] subset: 3_STAR synonym: "poisonous agent" RELATED [ChEBI] synonym: "poisonous agents" RELATED [ChEBI] synonym: "poisonous substance" RELATED [ChEBI] synonym: "poisonous substances" RELATED [ChEBI] synonym: "poisons" RELATED [ChEBI] synonym: "toxic agent" RELATED [ChEBI] synonym: "toxic agents" RELATED [ChEBI] synonym: "toxic substance" RELATED [ChEBI] synonym: "toxic substances" RELATED [ChEBI] xref: Wikipedia:Poison is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:65212 name: polysaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is any derivative of a polysaccharide." [] subset: 3_STAR synonym: "polysaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:18154 ! polysaccharide [Term] id: CHEBI:65255 name: food preservative namespace: chebi_ontology def: "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." [] subset: 3_STAR synonym: "food preservatives" RELATED [ChEBI] is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:65256 name: antimicrobial food preservative namespace: chebi_ontology def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." [] subset: 3_STAR synonym: "antimicrobial food preservatives" RELATED [ChEBI] synonym: "antimicrobial preservative" RELATED [ChEBI] synonym: "antimicrobial preservatives" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:65255 ! food preservative [Term] id: CHEBI:65296 name: primary ammonium ion namespace: chebi_ontology def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." [] subset: 3_STAR synonym: "a primary amine" RELATED [UniProt] synonym: "substituted ammonium" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound [Term] id: CHEBI:67079 name: anti-inflammatory agent namespace: chebi_ontology def: "Any compound that has anti-inflammatory effects." [] subset: 3_STAR synonym: "anti-inflammatory agents" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:72587 name: (R)-noradrenaline(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-noradrenaline" RELATED [UniProt] synonym: "(R)-noradrenaline cation" RELATED [ChEBI] synonym: "(R)-noradrenalinium cation" RELATED [ChEBI] synonym: "(R)-noradrenalinium(1+)" RELATED [ChEBI] xref: PDBeChem:E5E is_a: BFO:0000004 ! independent continuant is_a: CHEBI:166902 ! noradrenaline(1+) relationship: is_conjugate_acid_of CHEBI:18357 ! (R)-noradrenaline relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:72695 name: organic molecule namespace: chebi_ontology def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." [] subset: 3_STAR synonym: "organic compound" RELATED [ChEBI] synonym: "organic compounds" RELATED [ChEBI] synonym: "organic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72813 name: exopolysaccharide namespace: chebi_ontology def: "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." [] subset: 3_STAR synonym: "exopolysaccharides" RELATED [ChEBI] synonym: "extracellular polymeric substance" RELATED [ChEBI] synonym: "extracellular polymeric substances" RELATED [ChEBI] xref: MetaCyc:Exopolysaccharides xref: PMID:11160795 {source="Europe PMC"} xref: PMID:11785425 {source="Europe PMC"} xref: PMID:1444258 {source="Europe PMC"} xref: PMID:15738217 {source="Europe PMC"} xref: PMID:16075348 {source="Europe PMC"} xref: PMID:17440912 {source="Europe PMC"} xref: PMID:18097339 {source="Europe PMC"} xref: PMID:19453747 {source="Europe PMC"} xref: PMID:20172021 {source="Europe PMC"} xref: PMID:20631870 {source="Europe PMC"} xref: PMID:20718297 {source="Europe PMC"} xref: PMID:2688547 {source="Europe PMC"} xref: PMID:6354590 {source="Europe PMC"} xref: Wikipedia:Exopolysaccharide xref: Wikipedia:Extracellular_polymeric_substance is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:73398 name: indole skeleton namespace: chebi_ontology def: "A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring." [] subset: 3_STAR is_a: CHEBI:73541 ! organic heterobicyclic ring [Term] id: CHEBI:73541 name: organic heterobicyclic ring namespace: chebi_ontology def: "A bicyclic organic group that contains both carbon and hetero atoms." [] subset: 3_STAR synonym: "organic heterobicyclic rings" RELATED [ChEBI] is_a: CHEBI:52845 ! cyclic organic group [Term] id: CHEBI:75763 name: eukaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." [] subset: 3_STAR synonym: "eukaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75767 name: animal metabolite namespace: chebi_ontology alt_id: CHEBI:77721 alt_id: CHEBI:77743 def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." [] subset: 3_STAR synonym: "animal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:75768 name: mammalian metabolite namespace: chebi_ontology alt_id: CHEBI:77464 alt_id: CHEBI:77744 def: "Any animal metabolite produced during a metabolic reaction in mammals." [] subset: 3_STAR synonym: "mammalian metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:75771 name: mouse metabolite namespace: chebi_ontology def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." [] subset: 3_STAR synonym: "mouse metabolites" RELATED [ChEBI] synonym: "Mus musculus metabolite" RELATED [ChEBI] synonym: "Mus musculus metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:75772 name: Saccharomyces cerevisiae metabolite namespace: chebi_ontology alt_id: CHEBI:76949 alt_id: CHEBI:76951 def: "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." [] subset: 3_STAR synonym: "baker's yeast metabolite" RELATED [ChEBI] synonym: "baker's yeast metabolites" RELATED [ChEBI] synonym: "baker's yeast secondary metabolite" RELATED [ChEBI] synonym: "baker's yeast secondary metabolites" RELATED [ChEBI] synonym: "S. cerevisiae metabolite" RELATED [ChEBI] synonym: "S. cerevisiae metabolites" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:75787 name: prokaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." [] subset: 3_STAR synonym: "prokaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76206 name: xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound." [] subset: 3_STAR synonym: "xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor namespace: chebi_ontology def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." [] subset: 3_STAR synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.* inhibitors" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI] synonym: "hydrolase inhibitor" RELATED [ChEBI] synonym: "hydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Hydrolase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76764 name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor namespace: chebi_ontology def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." [] subset: 3_STAR synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76807 name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." [] subset: 3_STAR synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76924 name: plant metabolite namespace: chebi_ontology alt_id: CHEBI:75766 alt_id: CHEBI:76925 def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." [] subset: 3_STAR synonym: "plant metabolites" RELATED [ChEBI] synonym: "plant secondary metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76946 name: fungal metabolite namespace: chebi_ontology alt_id: CHEBI:75765 alt_id: CHEBI:76947 def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." [] subset: 3_STAR synonym: "fungal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76967 name: human xenobiotic metabolite namespace: chebi_ontology def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." [] subset: 3_STAR synonym: "human xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:76969 name: bacterial metabolite namespace: chebi_ontology alt_id: CHEBI:75760 alt_id: CHEBI:76970 def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." [] subset: 3_STAR is_a: CHEBI:75787 ! prokaryotic metabolite [Term] id: CHEBI:76971 name: Escherichia coli metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." [] subset: 3_STAR synonym: "E.coli metabolite" RELATED [ChEBI] synonym: "E.coli metabolites" RELATED [ChEBI] synonym: "Escherichia coli metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:77746 name: human metabolite namespace: chebi_ontology alt_id: CHEBI:75770 alt_id: CHEBI:77123 def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." [] subset: 3_STAR synonym: "H. sapiens metabolite" RELATED [ChEBI] synonym: "H. sapiens metabolites" RELATED [ChEBI] synonym: "Homo sapiens metabolite" RELATED [ChEBI] synonym: "Homo sapiens metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:77941 name: EC 3.5.1.4 (amidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." [] subset: 3_STAR synonym: "acylamidase inhibitor" RELATED [ChEBI] synonym: "acylamidase inhibitors" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI] synonym: "amidase inhibitor" RELATED [ChEBI] synonym: "amidase inhibitors" RELATED [ChEBI] synonym: "amidohydrolase inhibitor" RELATED [ChEBI] synonym: "amidohydrolase inhibitors" RELATED [ChEBI] synonym: "deaminase inhibitor" RELATED [ChEBI] synonym: "deaminase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI] synonym: "fatty acylamidase inhibitor" RELATED [ChEBI] synonym: "fatty acylamidase inhibitors" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Amidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:77974 name: food packaging gas namespace: chebi_ontology def: "A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container." [] subset: 3_STAR synonym: "food packaging gases" RELATED [ChEBI] xref: Wikipedia:Packaging_gas is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:78295 name: food component namespace: chebi_ontology def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." [] subset: 3_STAR synonym: "dietary component" RELATED [ChEBI] synonym: "dietary components" RELATED [ChEBI] synonym: "food components" RELATED [ChEBI] is_a: CHEBI:52211 ! physiological role [Term] id: CHEBI:78433 name: refrigerant namespace: chebi_ontology def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." [] subset: 3_STAR synonym: "refrigerants" RELATED [ChEBI] xref: Wikipedia:Refrigerant is_a: CHEBI:33232 ! application [Term] id: CHEBI:78608 name: alpha-amino-acid zwitterion namespace: chebi_ontology alt_id: CHEBI:83409 def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." [] subset: 3_STAR synonym: "alpha-amino acid zwitterion" RELATED [ChEBI] synonym: "alpha-amino acid zwitterions" RELATED [ChEBI] synonym: "alpha-amino-acid zwitterions" RELATED [ChEBI] synonym: "an alpha-amino acid" RELATED [UniProt] xref: MetaCyc:Alpha-Amino-Acids {source="SUBMITTER"} is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives namespace: chebi_ontology def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." [] subset: 3_STAR synonym: "carbohydrates and derivatives" RELATED [ChEBI] synonym: "carbohydrates and their derivatives" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:78675 name: fundamental metabolite namespace: chebi_ontology def: "Any metabolite produced by all living cells." [] subset: 3_STAR synonym: "essential metabolite" RELATED [ChEBI] synonym: "essential metabolites" RELATED [ChEBI] synonym: "fundamental metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:79388 name: divalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of two." [] subset: 3_STAR synonym: "divalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79389 name: monovalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of one." [] subset: 3_STAR synonym: "monovalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:83039 name: crustacean metabolite namespace: chebi_ontology def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." [] subset: 3_STAR synonym: "crustacean metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:83056 name: Daphnia magna metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia magna." [] subset: 3_STAR synonym: "Daphnia magna metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83057 name: Daphnia metabolite namespace: chebi_ontology def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" [] subset: 3_STAR synonym: "Daphnia metabolites" RELATED [ChEBI] xref: Wikipedia:Daphnia is_a: CHEBI:83039 ! crustacean metabolite [Term] id: CHEBI:84729 name: hydroxyindoles namespace: chebi_ontology def: "Any member of the class of indoles carrying at least one hydroxy group." [] subset: 3_STAR is_a: CHEBI:24828 ! indoles is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: cellxgene_subset subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! nucleus relationship: in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: CL:0000005 name: neural crest derived fibroblast def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] synonym: "fibroblast neural crest derived" EXACT [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] subset: cellxgene_subset synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell (metazoa) def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] synonym: "germline stem cell" EXACT [] is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] subset: cellxgene_subset xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0048477 ! oogenesis relationship: capable_of GO:0048477 ! oogenesis [Term] id: CL:0000022 name: female germ line stem cell def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FMA:18644 xref: MESH:D009865 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: participates_in GO:0007143 ! female meiotic nuclear division [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset xref: FMA:83673 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0000278 ! mitotic cell cycle relationship: capable_of GO:0000278 ! mitotic cell cycle relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FMA:67343 xref: MESH:D010063 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte relationship: participates_in GO:0007143 ! female meiotic nuclear division property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Egg_cell.svg xsd:anyURI [Term] id: CL:0000027 name: smooth muscle cell neural crest derived def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] synonym: "neuron neural crest derived" EXACT [] is_a: CL:0000540 {is_inferred="true"} ! neuron intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] subset: cellxgene_subset synonym: "neuroblast" EXACT [] xref: BTO:0000930 xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent [Term] id: CL:0000036 name: epithelial fate stem cell subset: cellxgene_subset subset: human_reference_atlas synonym: "epithelial stem cell" EXACT [] is_a: CL:0000035 ! single fate stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" RELATED OMO:0003000 [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:86475 xref: MESH:D006412 xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: capable_of GO:0048103 ! somatic stem cell division intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: general_cell_types_upper_slim subset: ubprop:upper_level is_a: CL:0000000 ! cell relationship: capable_of GO:0022414 ! reproductive process [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: capable_of GO:0030219 ! megakaryocyte differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000052 name: totipotent stem cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000055 name: non-terminally differentiated cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? subset: cellxgene_subset synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0011115 ! precursor cell [Term] id: CL:0000056 name: myoblast def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] subset: cellxgene_subset xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: NCIT:C12482 xref: VHOG:0001482 is_a: CL:0000499 ! stromal cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000058 name: chondroblast def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast relationship: produces UBERON:0002418 ! cartilage tissue [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] subset: cellxgene_subset xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: has_part GO:0005929 ! cilium relationship: has_part GO:0005929 ! cilium [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Epithelial_cells.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cilia." [GOC:tfm] subset: cellxgene_subset xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: has_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct [Term] id: CL:0000069 name: branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0004638 ! blood vessel endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000066 ! epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000076 name: squamous epithelial cell def: "Any epithelial cell that is part of some squamous epithelium." [FBC:Autogenerated] subset: cellxgene_subset xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0006914 ! squamous epithelium relationship: part_of UBERON:0006914 ! squamous epithelium [Term] id: CL:0000077 name: mesothelial cell def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328] comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"} subset: cellxgene_subset subset: human_reference_atlas synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: part_of UBERON:0001136 ! mesothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] subset: cellxgene_subset subset: general_cell_types_upper_slim xref: FMA:62844 xref: MESH:D001773 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0008015 ! blood circulation [Term] id: CL:0000082 name: epithelial cell of lung def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000115 ! lung epithelium relationship: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:0000083 name: epithelial cell of pancreas def: "An epithelial cell of the pancreas." [GOC:tfm] subset: cellxgene_subset synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000095 name: neuron associated cell subset: cellxgene_subset is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] subset: cellxgene_subset subset: human_reference_atlas synonym: "CNS interneuron" RELATED [] xref: BTO:0003811 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:2000029 ! central nervous system neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] subset: cellxgene_subset subset: human_reference_atlas synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0001037 xref: FMA:84649 xref: MESH:D011984 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000107 name: autonomic neuron def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 xref: MESH:D059329 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: CL:0000114 name: surface ectodermal cell def: "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." [doi:/10.1101/2024.07.02.601324, PMID:7892198, Wikipedia:Surface_ectoderm] subset: cellxgene_subset synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [doi:/10.1101/2024.07.02.601324] xref: FMA:72552 xref: https://cellxgene.cziscience.com/cellguide/CL_0000114 is_a: CL:0000221 ! ectodermal cell intersection_of: CL:0000221 ! ectodermal cell intersection_of: part_of UBERON:0000076 ! external ectoderm relationship: part_of UBERON:0000076 ! external ectoderm [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. subset: cellxgene_subset subset: human_reference_atlas synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0000255 ! eukaryotic cell relationship: develops_from CL:0000222 ! mesodermal cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 xref: https://cellxgene.cziscience.com/cellguide/CL_0000125 is_a: CL:0000095 ! neuron associated cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. subset: cellxgene_subset synonym: "BMSC" RELATED OMO:0003000 [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED OMO:0003000 [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED OMO:0003004 [] synonym: "MSC" RELATED OMO:0003000 [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/474 xsd:string [Term] id: CL:0000136 name: adipocyte def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "adipose cell" EXACT [] synonym: "fat cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000138 name: chondrocyte def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] subset: cellxgene_subset synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast relationship: located_in UBERON:0002418 ! cartilage tissue [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000149 name: visual pigment cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular secretory epithelial cell def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172] subset: cellxgene_subset synonym: "glandular epithelial cell" EXACT [] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002530 ! gland relationship: part_of UBERON:0002530 ! gland [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0032940 ! secretion by cell [Term] id: CL:0000152 name: exocrine cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] subset: general_cell_types_upper_slim xref: FMA:16014 is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: part_of UBERON:0002365 ! exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0009306 ! protein secretion relationship: capable_of GO:0009306 ! protein secretion [Term] id: CL:0000159 name: seromucus secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000164 {gci_relation="part_of", gci_filler="UBERON:0000945"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="part_of"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="part_of"} ! enteroendocrine cell is_a: CL:0000255 ! eukaryotic cell relationship: part_of UBERON:0000949 ! endocrine system property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000164 name: enteroendocrine cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] subset: cellxgene_subset xref: BTO:0003865 xref: FMA:62930 xref: https://cellxgene.cziscience.com/cellguide/CL_0000164 xref: MESH:D019858 is_a: CL:0000163 ! endocrine cell is_a: CL:1100001 ! secretory epithelial cell [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} subset: cellxgene_subset subset: human_reference_atlas synonym: "neurosecretory cell" RELATED [] synonym: "neurosecretory neuron" RELATED [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0046879 ! hormone secretion property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000167 name: peptide hormone secreting cell def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030072 ! peptide hormone secretion relationship: capable_of GO:0030072 ! peptide hormone secretion [Term] id: CL:0000168 name: insulin secreting cell def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated] xref: BTO:0000783 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030073 ! insulin secretion relationship: capable_of GO:0030073 ! insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. subset: cellxgene_subset subset: human_reference_atlas synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0030073 ! insulin secretion intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000170 name: glucagon secreting cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070091 ! glucagon secretion relationship: capable_of GO:0070091 ! glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas synonym: "alpha cell of islet of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 xref: MESH:D050416 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000172 name: somatostatin secreting cell def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070253 ! somatostatin secretion relationship: capable_of GO:0070253 ! somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000174 name: steroid hormone secreting cell def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035929 ! steroid hormone secretion relationship: capable_of GO:0035929 ! steroid hormone secretion [Term] id: CL:0000182 name: hepatocyte def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 xref: https://cellxgene.cziscience.com/cellguide/CL_0000182 is_a: CL:0000066 ! epithelial cell is_a: CL:0000417 ! endopolyploid cell relationship: capable_of GO:0006699 ! bile acid biosynthetic process relationship: capable_of GO:0098754 ! detoxification relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002107 ! liver property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [FB:ma] subset: cellxgene_subset is_a: CL:0000000 ! cell [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] subset: cellxgene_subset synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000393 ! electrically responsive cell relationship: develops_from CL:0000056 ! myoblast property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Muscle_cells.svg xsd:anyURI [Term] id: CL:0000188 name: cell of skeletal muscle def: "A somatic cell located in skeletal muscle." [GOC:tfm] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 xref: https://cellxgene.cziscience.com/cellguide/CL_0000188 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000192 name: smooth muscle cell def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" BROAD [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 xref: https://cellxgene.cziscience.com/cellguide/CL_0000192 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] synonym: "receptor cell" EXACT [] xref: MESH:D011984 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: part_of UBERON:0001032 ! sensory system relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of UBERON:0001032 ! sensory system [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786] subset: cellxgene_subset xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FMA:86740 is_a: CL:0000101 ! sensory neuron is_a: CL:0008028 ! visual system neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg xsd:anyURI [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000213 name: lining cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] synonym: "synoviocyte" EXACT [] xref: CALOHA:TS-0995 is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell relationship: part_of UBERON:0002217 ! synovial joint [Term] id: CL:0000215 name: barrier cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0048870 ! cell motility relationship: capable_of GO:0048870 ! cell motility [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] subset: cellxgene_subset synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [MESH:D008648] subset: cellxgene_subset synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 xref: https://cellxgene.cziscience.com/cellguide/CL_0000222 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate] synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate] synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: capable_of GO:0015671 ! oxygen transport intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0000053 PATO:0002039 ! has characteristic biconcave relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: develops_from CL:0000558 ! reticulocyte relationship: RO:0000053 PATO:0002039 ! has characteristic biconcave property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000255 name: eukaryotic cell def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated] xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: in_taxon NCBITaxon:2759 ! Eukaryota relationship: in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: CL:0000287 name: eye photoreceptor cell def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000293 name: structural cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000000 ! cell [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FMA:18649 xref: https://cellxgene.cziscience.com/cellguide/CL_0000300 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0009566 ! fertilization intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid relationship: capable_of GO:0009566 ! fertilization [Term] id: CL:0000306 name: crystallin accumulating cell subset: eye_upper_slim synonym: "lens cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell def: "An epithelial cell found in the trachea." [GOC:tfm] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from CL:0000377 ! tracheoblast relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:0000313 name: serous secreting cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] subset: cellxgene_subset synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000319 name: mucus secreting cell def: "Any cell that is capable of some mucus secretion." [FBC:Autogenerated] subset: cellxgene_subset synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0070254 ! mucus secretion relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: ubprop:upper_level is_a: CL:0000000 ! cell [Term] id: CL:0000327 name: extracellular matrix secreting cell is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0015671 ! oxygen transport relationship: capable_of GO:0015671 ! oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000347 name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] subset: eye_upper_slim is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye def: "A structural cell that is part of optic choroid." [GOC:add] subset: eye_upper_slim is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] subset: cellxgene_subset subset: general_cell_types_upper_slim is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754] synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8] xref: FMA:83028 xref: https://cellxgene.cziscience.com/cellguide/CL_0000351 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell relationship: develops_from CL:1000274 ! trophectodermal cell [Term] id: CL:0000352 name: epiblast cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. xref: FMA:86767 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000358 name: sphincter associated smooth muscle cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] xref: https://cellxgene.cziscience.com/cellguide/CL_0000358 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0000359 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000362 name: epidermal cell def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] subset: cellxgene_subset synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelium relationship: part_of UBERON:0007376 ! outer epithelium [Term] id: CL:0000365 name: animal zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] synonym: "zygote" BROAD [] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: in_taxon NCBITaxon:33208 ! Metazoa relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: CL:0000377 name: tracheoblast is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion relationship: RO:0002100 UBERON:0000045 ! has soma location ganglion [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000412 name: polyploid cell def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001377 ! has characteristic polyploid relationship: RO:0000053 PATO:0001377 ! has characteristic polyploid [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid relationship: RO:0000053 PATO:0001375 ! has characteristic haploid [Term] id: CL:0000417 name: endopolyploid cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000447 name: carbohydrate secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000457 name: biogenic amine secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001820 ! serotonin secretion relationship: capable_of GO:0001820 ! serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] subset: cellxgene_subset synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion relationship: capable_of GO:0048243 ! norepinephrine secretion [Term] id: CL:0000488 name: visible light photoreceptor cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009584 ! detection of visible light relationship: capable_of GO:0009584 ! detection of visible light [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue." [GOC:tfm, MESH:D017154] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000502 name: type D enteroendocrine cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] subset: cellxgene_subset synonym: "D cell" EXACT [] xref: FMA:62935 xref: https://cellxgene.cziscience.com/cellguide/CL_0000502 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell def: "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863, PMID:10700044, PMID:35674015, PMID:37240181] subset: cellxgene_subset synonym: "G cell" EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell [Term] id: CL:0000509 name: gastrin secreting cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] subset: human_reference_atlas is_a: CL:0000167 ! peptide hormone secreting cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000513 name: cardiac muscle myoblast def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] subset: cellxgene_subset synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue relationship: part_of UBERON:0001133 ! cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] subset: cellxgene_subset synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 xref: https://cellxgene.cziscience.com/cellguide/CL_0000514 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000192 ! smooth muscle cell relationship: develops_into CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 ! myoblast is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell relationship: develops_into CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000521 name: fungal cell def: "Any cell that in taxon some Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: in_taxon NCBITaxon:4751 ! Fungi relationship: in_taxon NCBITaxon:4751 ! Fungi [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_reference_atlas synonym: "plasmidotrophoblast cell" RELATED [] synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 is_a: CL:0000351 ! trophoblast cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: part_of UBERON:0000371 ! syncytiotrophoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/2100 xsd:string [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] subset: human_reference_atlas synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] subset: cellxgene_subset synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Neuron_cells.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_part CL:0017503 ! basophilic cytoplasm intersection_of: has_part GO:0005730 ! nucleolus intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_part CL:0017503 ! basophilic cytoplasm relationship: has_part GO:0005730 ! nucleolus relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017503 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: has_part CL:0017503 ! basophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017504 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CL:0017504 ! polychromatophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017502 ! acidophilic cytoplasm intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CL:0017502 ! acidophilic cytoplasm relationship: participates_in GO:0030263 ! apoptotic chromosome condensation [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0007113 ! endomitotic cell cycle intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: capable_of GO:0007113 ! endomitotic cell cycle relationship: capable_of GO:0030219 ! megakaryocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000556 name: megakaryocyte def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell relationship: RO:0000053 PATO:0001393 ! has characteristic euploid property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] subset: blood_and_immune_upper_slim subset: cellxgene_subset xref: BTO:0001173 xref: CALOHA:TS-0864 xref: MESH:D012156 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0071971 ! extracellular exosome assembly intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: capable_of GO:0071971 ! extracellular exosome assembly relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated relationship: develops_from CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000566 name: angioblastic mesenchymal cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 relationship: develops_from CL:0000134 ! mesenchymal stem cell relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] subset: cellxgene_subset is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: develops_into CL:0002494 ! cardiocyte relationship: develops_into CL:0002494 ! cardiocyte [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] subset: cellxgene_subset subset: human_reference_atlas synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000575 name: corneal epithelial cell def: "An epithelial cell of the cornea." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0001772 ! corneal epithelium relationship: part_of UBERON:0001772 ! corneal epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [MESH:D005854] subset: cellxgene_subset xref: BTO:0000535 xref: NCIT:C12597 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: capable_of_part_of GO:0009566 ! fertilization [Term] id: CL:0000593 name: androgen secreting cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035935 ! androgen secretion relationship: capable_of GO:0035935 ! androgen secretion [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] subset: cellxgene_subset subset: human_reference_atlas synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] subset: cellxgene_subset synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 xref: https://cellxgene.cziscience.com/cellguide/CL_0000622 xref: MESH:D061354 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000154 ! protein secreting cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: CL:0000154 ! protein secreting cell intersection_of: part_of UBERON:0009842 ! glandular acinus relationship: part_of UBERON:0009842 ! glandular acinus [Term] id: CL:0000630 name: supporting cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] subset: cellxgene_subset synonym: "supportive cell" EXACT [] xref: BTO:0002315 is_a: CL:0000000 ! cell [Term] id: CL:0000666 name: fenestrated endothelial cell def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] subset: cellxgene_subset synonym: "window cell" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0000666 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: RO:0000053 PATO:0002064 ! has characteristic fenestrated relationship: RO:0000053 PATO:0002064 ! has characteristic fenestrated [Term] id: CL:0000667 name: collagen secreting cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] subset: cellxgene_subset is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] subset: cellxgene_subset synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0048870 ! cell motility intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000680 name: muscle precursor cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] subset: cellxgene_subset is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0011115 ! precursor cell intersection_of: develops_into CL:0000187 ! muscle cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_into CL:0000187 ! muscle cell [Term] id: CL:0000696 name: PP cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] subset: cellxgene_subset synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 xref: https://cellxgene.cziscience.com/cellguide/CL_0000696 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: MESH:D053687 is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: capable_of GO:0048103 ! somatic stem cell division relationship: capable_of GO:0048103 ! somatic stem cell division [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: has_part GO:0030017 ! sarcomere intersection_of: RO:0000053 PATO:0001410 ! has characteristic striated disjoint_from: CL:0008000 ! non-striated muscle cell relationship: has_part GO:0030017 ! sarcomere relationship: RO:0000053 PATO:0001410 ! has characteristic striated [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] subset: cellxgene_subset subset: human_reference_atlas synonym: "immune cell" RELATED [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 xref: MESH:D007962 xref: NCIT:C12529 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002405 ! immune system property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] xref: BTO:0001800 xref: FMA:67765 xref: MESH:D012165 is_a: CL:0000540 ! neuron relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002100 UBERON:0000966 ! has soma location retina property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000746 name: cardiac muscle cell def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 xref: https://cellxgene.cziscience.com/cellguide/CL_0000746 xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0007100 ! primary circulatory organ intersection_of: participates_in GO:0060047 ! heart contraction intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: participates_in GO:0060047 ! heart contraction relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] subset: cellxgene_subset xref: BTO:0001441 xref: CALOHA:TS-0647 xref: MESH:D022423 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. subset: cellxgene_subset subset: human_reference_atlas synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 xref: MESH:D004900 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_part GO:0005634 ! nucleus relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part GO:0005634 ! nucleus [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] subset: cellxgene_subset is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_reference_atlas synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030099 ! myeloid cell differentiation relationship: capable_of GO:0030099 ! myeloid cell differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000850 name: serotonergic neuron def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: MESH:D059326 xref: WBbt:0006837 is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] subset: cellxgene_subset synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000000 ! cell [Term] id: CL:0001035 name: bone cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] subset: general_cell_types_upper_slim subset: human_reference_atlas xref: https://cellxgene.cziscience.com/cellguide/CL_0001035 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9990-8331 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] subset: cellxgene_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] subset: blood_and_immune_upper_slim is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). subset: blood_and_immune_upper_slim is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell relationship: RO:0000053 PATO:0001401 ! has characteristic oligopotent property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002064 name: pancreatic acinar cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] subset: cellxgene_subset subset: human_reference_atlas synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 xref: https://cellxgene.cziscience.com/cellguide/CL_0002064 is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 ! zymogen granule membrane relationship: part_of UBERON:0001263 ! pancreatic acinus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002067 name: type A enteroendocrine cell def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] subset: cellxgene_subset xref: FMA:62939 xref: https://cellxgene.cziscience.com/cellguide/CL_0002067 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0070091 ! glucagon secretion property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] subset: human_reference_atlas synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] subset: cellxgene_subset xref: FMA:69075 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000223 ! endodermal cell relationship: develops_from CL:0000223 ! endodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000221 ! ectodermal cell relationship: develops_from CL:0000221 ! ectodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000222 ! mesodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:63099 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001064 ! ventral pancreatic duct property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] subset: human_reference_atlas synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001263 ! pancreatic acinus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [GOC:tfm] subset: blood_and_immune_upper_slim synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. subset: cellxgene_subset subset: human_reference_atlas synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction relationship: capable_of GO:0043134 ! regulation of hindgut contraction property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. subset: cellxgene_subset xref: BTO:0004850 xref: FMA:83621 xref: MESH:D001854 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002095 name: hilus cell of ovary def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] subset: human_reference_atlas synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [GOC:tfm] subset: cellxgene_subset synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. subset: cellxgene_subset synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 xref: https://cellxgene.cziscience.com/cellguide/CL_0002139 is_a: CL:0000115 ! endothelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002144 name: capillary endothelial cell def: "An endothelial cell found in capillaries." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002178 name: epithelial cell of stomach def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach relationship: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002180 name: mucous cell of stomach def: "An epithelial cell of the stomach. This cell produces mucous." [GOC:tfm] xref: FMA:63464 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002178 ! epithelial cell of stomach is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0070254 ! mucus secretion intersection_of: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002183 name: stem cell of gastric gland def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0008397 ! tracheobronchial epithelium relationship: part_of UBERON:0008397 ! tracheobronchial epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002209 name: intermediate epitheliocyte def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] subset: eye_upper_slim xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: part_of UBERON:0000965 ! lens of camera-type eye property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002224 name: lens epithelial cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0010001 ! stromal cell of bone marrow intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] subset: cellxgene_subset synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 xref: https://cellxgene.cziscience.com/cellguide/CL_0002243 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002246 name: peripheral blood stem cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 xref: MESH:D000072916 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002250 name: intestinal crypt stem cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset synonym: "stem cell of intestinal crypt of Lieberkuhn" EXACT [] xref: FMA:63379 xref: https://cellxgene.cziscience.com/cellguide/CL_0002250 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003929 ! digestive tract epithelium relationship: part_of UBERON:0003929 ! digestive tract epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus def: "An epithelial cell of the lining of the esophagus." [GOC:tfm] subset: cellxgene_subset xref: FMA:63071 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus relationship: part_of UBERON:0001976 ! epithelium of esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine def: "An epithelial cell of the lining of the large intestine." [GOC:tfm] subset: cellxgene_subset synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine def: "An epithelial cell of the lining of the small intestine." [GOC:tfm] subset: cellxgene_subset xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002262 name: endothelial cell of sinusoid def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:63134 xref: https://cellxgene.cziscience.com/cellguide/CL_0002262 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002264 name: type A cell of stomach def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:1001517 ! stomach enteroendocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon def: "A D cell located in the colon." [GOC:tfm] synonym: "colon D-cell" EXACT [] synonym: "colonic delta cell" EXACT [] synonym: "delta cell of colon" EXACT [] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009042 ! enteroendocrine cell of colon is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine def: "A type D cell of the small intestine." [GOC:tfm] synonym: "delta cell of small intestine" EXACT [] synonym: "small intestine D-cell" EXACT [] synonym: "small intestine delta cell" EXACT [] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009006 ! enteroendocrine cell of small intestine intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach def: "A type D cell found in the stomach." [GOC:tfm] synonym: "delta cell of stomach" EXACT [] synonym: "stomach D-cell" EXACT [] synonym: "stomach delta cell" EXACT [] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach is_a: CL:1000222 ! stomach neuroendocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002275 name: pancreatic PP cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. subset: cellxgene_subset subset: human_reference_atlas synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 xref: https://cellxgene.cziscience.com/cellguide/CL_0002275 xref: MESH:D050418 is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002308 name: epithelial cell of skin gland def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset xref: CALOHA:TS-2096 xref: FMA:63875 xref: MESH:D003239 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell (metazoa) def: "A cell of the embryo." [FMA:0618947256] xref: CALOHA:TS-0263 xref: FMA:82840 xref: https://cellxgene.cziscience.com/cellguide/CL_0002321 xref: WBbt:0007028 is_a: CL:0000000 ! cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002328 name: bronchial epithelial cell def: "An epithelial cell of the bronchus." [GOC:tfm] subset: cellxgene_subset xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002333 name: neural crest derived adipocyte def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000005 ! neural crest derived fibroblast property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002350 name: endocardial cell def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] subset: cellxgene_subset subset: human_reference_atlas synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 xref: https://cellxgene.cziscience.com/cellguide/CL_0002350 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667] subset: cellxgene_subset synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0011026 ! progenitor cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002368 name: respiratory tract epithelial cell def: "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [GOC:tfm] subset: cellxgene_subset synonym: "airway epithelial cell" EXACT [] synonym: "respiratory epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium relationship: part_of UBERON:0004802 ! respiratory tract epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002372 name: myotube def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] subset: cellxgene_subset synonym: "myofiber" EXACT [FBbt:00005812] synonym: "myofibril" EXACT [FBbt:00005812] is_a: CL:0000737 ! striated muscle cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000187 ! muscle cell intersection_of: has_part GO:0030017 ! sarcomere intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002494 name: cardiocyte def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0007100 ! primary circulatory organ relationship: part_of UBERON:0007100 ! primary circulatory organ property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002503 name: adventitial cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] subset: cellxgene_subset xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0005742 ! adventitia relationship: part_of UBERON:0005742 ! adventitia property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell def: "A smooth muscle cell of the intestine." [GOC:tfm] subset: cellxgene_subset synonym: "intestinal smooth muscle cell" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0002504 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002521 name: subcutaneous adipocyte def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "subcutaneous fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002538 name: intrahepatic cholangiocyte def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] subset: cellxgene_subset synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296] xref: https://cellxgene.cziscience.com/cellguide/CL_0002538 is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell def: "A smooth muscle cell of the aorta." [GOC:tfm] subset: cellxgene_subset xref: BTO:0004577 xref: https://cellxgene.cziscience.com/cellguide/CL_0002539 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002543 name: vein endothelial cell def: "An endothelial cell that is part of the vein." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: https://cellxgene.cziscience.com/cellguide/CL_0002543 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia relationship: part_of UBERON:0004664 ! aorta tunica adventitia property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue def: "A fibroblast that is part of the heart." [GOC:tfm] subset: cellxgene_subset synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002494 {is_inferred="true"} ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002551 name: fibroblast of dermis def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002553 name: fibroblast of lung def: "A fibroblast that is part of lung." [GOC:tfm] subset: cellxgene_subset xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery def: "A fibroblast of pulmonary artery." [GOC:tfm] subset: human_reference_atlas is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002563 name: intestinal epithelial cell def: "An epithelial cell of the lining of the intestine." [GOC:tfm] subset: cellxgene_subset is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium relationship: part_of UBERON:0001277 ! intestinal epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] subset: cellxgene_subset synonym: "mesenchymal stem cell of adipose" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0002570 is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell def: "A mesenchymal stem cell of liver." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002107 ! liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002574 name: stromal cell of pancreas def: "A stromal cell of the pancreas." [GOC:tfm] subset: human_reference_atlas is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002585 name: retinal blood vessel endothelial cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas xref: https://cellxgene.cziscience.com/cellguide/CL_0002585 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 ! brachiocephalic artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery def: "A smooth muscle of the pulmonary artery." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0003336 xref: https://cellxgene.cziscience.com/cellguide/CL_0002591 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001533 ! subclavian artery relationship: part_of UBERON:0001533 ! subclavian artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002598 name: bronchial smooth muscle cell def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0004402 xref: https://cellxgene.cziscience.com/cellguide/CL_0002598 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea def: "A smooth muscle cell of the trachea." [GOC:tfm] subset: cellxgene_subset xref: https://cellxgene.cziscience.com/cellguide/CL_0002600 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002610 name: raphe nuclei neuron def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002620 name: skin fibroblast def: "A fibroblast of skin." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0002368 ! respiratory tract epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004815 ! lower respiratory tract epithelium relationship: part_of UBERON:0004815 ! lower respiratory tract epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002653 name: squamous endothelial cell def: "A squamous shaped endothelial cell." [GOC:dos] is_a: CL:0000115 ! endothelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002657 name: glandular cell of esophagus def: "A glandular epithelial cell of the esophagus." [GOC:tfm] subset: cellxgene_subset xref: FMA:86548 is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine def: "A glandular epithelial cell of the large intestine." [GOC:tfm] xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular epithelial cell of stomach def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] synonym: "glandular cell of stomach" EXACT [] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] synonym: "CPC" RELATED OMO:0003000 [PMID:19745164] is_a: CL:0000048 ! multi fate stem cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002672 name: retinal progenitor cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] subset: cellxgene_subset is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000133 ! neurectodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002676 name: neural crest derived neuroblast def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0000333 ! migratory neural crest cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002680 name: PP cell of intestine def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] is_a: CL:0000696 {is_inferred="true"} ! PP cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS] synonym: "somatic motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron is_a: CL:0000108 ! cholinergic neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of RO:0002577 ! system relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] subset: cellxgene_subset xref: https://cellxgene.cziscience.com/cellguide/CL_0005026 is_a: CL:0000048 ! multi fate stem cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string [Term] id: CL:0007001 name: skeletogenic cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000000 ! cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007004 name: premigratory neural crest cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: CL:0011012 ! neural crest cell relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0002342 ! neural crest property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007009 name: prechondroblast def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] subset: cellxgene_subset is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: develops_from CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:8600004 ! visceral muscle tissue relationship: part_of UBERON:8600004 ! visceral muscle tissue [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! has characteristic striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! has characteristic transversely striated relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. synonym: "myogenic precursor cell" BROAD [PMID:23303905] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] subset: cellxgene_subset subset: human_reference_atlas synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell relationship: capable_of GO:0016477 ! cell migration relationship: part_of UBERON:0003104 ! mesenchyme property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: part_of UBERON:0002062 ! endocardial cushion relationship: part_of UBERON:0002062 ! endocardial cushion [Term] id: CL:0008024 name: pancreatic endocrine cell def: "An endocrine cell that is part of the pancreas." [GOC:dos] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000163 ! endocrine cell intersection_of: part_of UBERON:0001264 ! pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos] is_a: CL:0000459 ! noradrenergic cell is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission [Term] id: CL:0008028 name: visual system neuron def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of_part_of GO:0007601 ! visual perception relationship: capable_of_part_of GO:0007601 ! visual perception property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2017-07-09T19:12:36Z [Term] id: CL:0008034 name: mural cell def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas is_a: CL:4033054 ! perivascular cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2020-02-29T17:33:55Z [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0010523 ! microcirculatory vessel relationship: part_of UBERON:0010523 ! microcirculatory vessel property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-02-29T17:37:00Z [Term] id: CL:0008041 name: mesothelial cell of intestine def: "A mesothelial cell that is part of the intestinal serosa." [https://orcid.org/0000-0002-7073-9172] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001243 ! serosa of intestine relationship: part_of UBERON:0001243 ! serosa of intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 property_value: http://purl.org/dc/terms/date 2025-02-04T18:42:26Z xsd:dateTime [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] synonym: "spinal sensory neuron" EXACT [] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] subset: general_cell_types_upper_slim xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: part_of UBERON:0005388 ! photoreceptor array relationship: part_of UBERON:0005388 ! photoreceptor array [Term] id: CL:0009006 name: enteroendocrine cell of small intestine def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: location_grouping synonym: "small intestine enteroendocrine cell" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0009006 is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009016 name: intestinal crypt stem cell of large intestine def: "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682] subset: cellxgene_subset subset: human_reference_atlas subset: location_grouping synonym: "crypt stem cell of large intestine" BROAD [] synonym: "stem cell of large intestine crypt of Lieberkuhn" EXACT [] is_a: CL:0002250 ! intestinal crypt stem cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine relationship: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0009017 name: intestinal crypt stem cell of small intestine def: "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682] subset: cellxgene_subset subset: location_grouping synonym: "crypt stem cell of small intestine" BROAD [] synonym: "stem cell of small intestine crypt of Lieberkuhn" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0009017 is_a: CL:0002250 ! intestinal crypt stem cell is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine relationship: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009021 name: stromal cell of lamina propria of large intestine def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine relationship: part_of UBERON:0011189 ! lamina propria of large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009022 name: stromal cell of lamina propria of small intestine def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: location_grouping is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009024 name: mesothelial cell of small intestine def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping is_a: CL:0008041 ! mesothelial cell of intestine intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001206 ! serosa of small intestine relationship: part_of UBERON:0001206 ! serosa of small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009025 name: mesothelial cell of colon def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] subset: location_grouping synonym: "mesothelial cell of large intestine" BROAD [] is_a: CL:0008041 ! mesothelial cell of intestine intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0003335 ! serosa of colon relationship: part_of UBERON:0003335 ! serosa of colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009040 name: stromal cell of lamina propria of colon def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "stromal cell of colon lamina propria" EXACT [] is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0007177 ! lamina propria of mucosa of colon relationship: part_of UBERON:0007177 ! lamina propria of mucosa of colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009042 name: enteroendocrine cell of colon def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: location_grouping synonym: "colon enteroendocrine cell" EXACT [] is_a: CL:0011108 ! colon epithelial cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009043 name: intestinal crypt stem cell of colon def: "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon." [http://orcid.org/0000-0003-3440-1876, PMID:10841502] subset: cellxgene_subset subset: location_grouping xref: https://cellxgene.cziscience.com/cellguide/CL_0009043 is_a: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon relationship: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009052 name: smooth muscle cell of anorectum def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "anorectum smooth muscle cell" EXACT [] is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009053 name: stromal cell of anorectum lamina propria def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009061 name: intestinal crypt stem cell of anorectum def: "An intestinal crypt stem cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "anorectum intestinal crypt stem cell" EXACT [] is_a: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009063 name: enteroendocrine cell of anorectum def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "anorectum enteroendocrine cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009094 name: endothelial cell of hepatic portal vein def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] subset: location_grouping synonym: "portal endothelial cell" BROAD [] xref: EFO:0010704 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001639 ! hepatic portal vein relationship: part_of UBERON:0001639 ! hepatic portal vein property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2021-12-13T14:01:05Z xsd:dateTime [Term] id: CL:0009097 name: embryonic skeletal muscle fiber def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: existence_starts_and_ends_during UBERON:0000068 ! embryo stage relationship: existence_starts_and_ends_during UBERON:0000068 ! embryo stage property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2022-02-21T15:39:10Z xsd:dateTime [Term] id: CL:0009100 name: hepatic portal fibroblast def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] subset: human_reference_atlas synonym: "portal fibroblast" BROAD [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001279 ! portal triad relationship: part_of UBERON:0001279 ! portal triad property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2022-03-17T12:00:44Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000948 ! heart [Term] id: CL:0010007 name: His-Purkinje system cell def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0004146 ! His-Purkinje system relationship: part_of UBERON:0004146 ! His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas xref: https://cellxgene.cziscience.com/cellguide/CL_0010008 is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010009 name: camera-type eye photoreceptor cell def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0000966 {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://github.com/obophenotype/cell-ontology/issues/2245"} ! retina [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] xref: MESH:D015053 is_a: CL:0000000 ! cell relationship: seeAlso https://github.com/obophenotype/cell-ontology/issues/786 [Term] id: CL:0010020 name: cardiac glial cell def: "Any glial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010021 name: cardiac myoblast def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell relationship: develops_into CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] comment: This term is used in 3 GO terms that were created as part of the heart development focus project. subset: cellxgene_subset is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002100 UBERON:0000948 ! has soma location heart property_value: seeAlso https://github.com/obophenotype/cell-ontology/pull/1488 xsd:string [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] subset: cellxgene_subset is_a: CL:0000100 {is_inferred="true"} ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord [Term] id: CL:0011007 name: paraxial cell def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] synonym: "paraxial mesoderm cell" EXACT [] synonym: "presomitic mesoderm cell" NARROW [] synonym: "somitic mesoderm cell" EXACT [] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: part_of UBERON:0003059 ! presomitic mesoderm relationship: part_of UBERON:0003059 ! presomitic mesoderm [Term] id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] subset: cellxgene_subset xref: https://cellxgene.cziscience.com/cellguide/CL_0011012 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0011019 name: mesothelial cell of epicardium def: "A mesothelial cell that is part of the epicardium." [] subset: cellxgene_subset is_a: CL:0000077 ! mesothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002348 ! epicardium relationship: part_of UBERON:0002348 ! epicardium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011021 name: fibroblast of upper back skin def: "A fibroblast that is part of upper back skin." [] is_a: CL:0011022 ! fibroblast of skin of back intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0009015 ! upper back skin relationship: part_of UBERON:0009015 ! upper back skin property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011022 name: fibroblast of skin of back def: "A fibroblast that is part of skin of back." [] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001068 ! skin of back relationship: part_of UBERON:0001068 ! skin of back property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] subset: cellxgene_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: develops_from CL:0000034 ! stem cell relationship: develops_from CL:0000034 ! stem cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011027 name: skeletal muscle fibroblast def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] subset: cellxgene_subset synonym: "skeleton muscle fibroblast" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0011027 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011030 name: dermal microvascular endothelial cell def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] synonym: "dermal microvascular endothelium cell" EXACT [] synonym: "DMEC cell" EXACT [] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] subset: cellxgene_subset synonym: "colonic epithelial cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000397 ! colonic epithelium relationship: part_of UBERON:0000397 ! colonic epithelium [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. subset: cellxgene_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0030154 ! cell differentiation relationship: capable_of GO:0030154 ! cell differentiation [Term] id: CL:0017502 name: acidophilic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002418 ! has characteristic acidophilic relationship: RO:0000053 PATO:0002418 ! has characteristic acidophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:23:25Z [Term] id: CL:0017503 name: basophilic cytoplasm def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002094 ! has characteristic basophilic relationship: RO:0000053 PATO:0002094 ! has characteristic basophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:24:54Z [Term] id: CL:0017504 name: polychromatophilic cytoplasm def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic relationship: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-28T04:25:23Z [Term] id: CL:0019001 name: tracheobronchial serous cell def: "Any serous secreting cell that is part of the tracheobronchial epithelium." [] subset: added_for_HCA subset: cellxgene_subset synonym: "serous cell of tracheobronchial tree" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0019001 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000313 ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-05-07T16:03:27Z xsd:dateTime [Term] id: CL:0019002 name: tracheobronchial chondrocyte def: "Any chondrocyte that is part of the tracheobronchial tree." [] subset: added_for_HCA subset: human_reference_atlas synonym: "chondrocyte of tracheobronchial tree" EXACT [] is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-05-07T17:29:51Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019018 name: blood vessel smooth muscle cell def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] subset: cellxgene_subset subset: human_reference_atlas synonym: "smooth muscle cell of blood vessel" EXACT [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-07-21T12:42:48Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] comment: The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the Lung with a confidence of 0.69 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas synonym: "smooth muscle cell of tracheobronchial tree" EXACT [] xref: https://cellxgene.cziscience.com/cellguide/CL_0019019 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree relationship: RO:0015004 CLM:1000056 ! has characterizing marker set property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-07-21T12:50:22Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019020 name: extrahepatic cholangiocyte def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296] is_a: CL:1000488 ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: part_of UBERON:0004822 ! extrahepatic bile duct epithelium relationship: part_of UBERON:0004822 ! extrahepatic bile duct epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-03T12:24:24Z xsd:dateTime [Term] id: CL:0019021 name: endothelial cell of periportal hepatic sinusoid def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "periportal LSEC" EXACT [PMID:28287163] xref: EFO:0010705 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: adjacent_to UBERON:0001279 ! portal triad relationship: adjacent_to UBERON:0001279 ! portal triad property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-09T13:56:47Z xsd:dateTime [Term] id: CL:0019022 name: endothelial cell of pericentral hepatic sinusoid def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "pericentral LSEC" EXACT [PMID:28287163] xref: EFO:0010706 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: adjacent_to UBERON:0006841 ! central vein of liver relationship: adjacent_to UBERON:0006841 ! central vein of liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-10T12:38:29Z xsd:dateTime [Term] id: CL:1000222 name: stomach neuroendocrine cell def: "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles." [PMID:15153415] synonym: "DES cell" BROAD [PMID:15153415] synonym: "diffuse endocrine system cell" BROAD [PMID:15153415] is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1001517 ! stomach enteroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach relationship: capable_of GO:0046717 ! acid secretion relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) [Term] id: CL:1000223 name: pulmonary neuroendocrine cell def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] comment: The marker set CHGA, GRP can identify the Human cell type lung neuroendocrine cell in the Lung with a confidence of 0.94 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas synonym: "lung neuroendocrine cell" EXACT [PMID:15018448] synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253] xref: https://cellxgene.cziscience.com/cellguide/CL_1000223 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0002048 ! lung relationship: capable_of GO:0070483 ! detection of hypoxia relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_part GO:0031045 ! dense core granule relationship: RO:0015004 CLM:1000043 ! has characterizing marker set property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000272 name: lung secretory cell def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000274 name: trophectodermal cell def: "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." [PMID:22918806] synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0004345 ! trophectoderm relationship: develops_into CL:0000351 ! trophoblast cell relationship: part_of UBERON:0004345 ! trophectoderm [Term] id: CL:1000275 name: smooth muscle cell of small intestine def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] subset: cellxgene_subset synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] xref: FMA:15050 xref: https://cellxgene.cziscience.com/cellguide/CL_1000275 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000276 name: smooth muscle fiber of duodenum def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] xref: FMA:15058 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0001902 ! epithelium of small intestine relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000279 name: smooth muscle cell of large intestine def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] xref: FMA:15653 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000280 name: smooth muscle cell of colon def: "A smooth muscle cell that is part of the colon." [GOC:tfm] synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] xref: FMA:15663 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001278 ! epithelium of large intestine [Term] id: CL:1000285 name: smooth muscle cell of sigmoid colon def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] xref: FMA:17521 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon [Term] id: CL:1000286 name: smooth muscle cell of rectum def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] synonym: "smooth muscle fiber of rectum" EXACT [] xref: FMA:17522 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001278 ! epithelium of large intestine [Term] id: CL:1000303 name: fibroblast of areolar connective tissue def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] xref: FMA:261279 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0006815 ! areolar connective tissue relationship: part_of UBERON:0006815 ! areolar connective tissue [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] xref: FMA:261285 is_a: CL:4052030 ! adventitial fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0007240 ! tunica adventitia of artery relationship: part_of UBERON:0007240 ! tunica adventitia of artery [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0007846 ! dense regular connective tissue relationship: part_of UBERON:0002521 ! elastic tissue relationship: part_of UBERON:0007846 ! dense regular connective tissue [Term] id: CL:1000309 name: epicardial adipocyte def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte relationship: part_of UBERON:0002348 ! epicardium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] subset: cellxgene_subset synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: CL:1000330 name: serous cell of epithelium of trachea def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:263078 xref: https://cellxgene.cziscience.com/cellguide/CL_1000330 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000331 name: serous cell of epithelium of bronchus def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:263080 xref: https://cellxgene.cziscience.com/cellguide/CL_1000331 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000361 name: transitional myocyte of interatrial septum def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263182 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000398 name: endothelial cell of hepatic sinusoid def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] subset: cellxgene_subset subset: human_reference_atlas synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "LSEC" EXACT [PMID:30348985] xref: BTO:000125 xref: FMA:62911 xref: https://cellxgene.cziscience.com/cellguide/CL_1000398 is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002262 ! endothelial cell of sinusoid intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: part_of UBERON:0001281 ! hepatic sinusoid property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000409 name: myocyte of sinoatrial node def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] subset: cellxgene_subset synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000412 name: endothelial cell of arteriole def: "An endothelial cell that is part of the arteriole." [GOC:tfm] subset: human_reference_atlas xref: FMA:67760 xref: KUPO:0001097 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000413 name: endothelial cell of artery def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: https://cellxgene.cziscience.com/cellguide/CL_1000413 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001917 ! endothelium of artery property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000414 name: endothelial cell of venule def: "An endothelial cell that is part of the venule." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000415 name: epithelial cell of gallbladder def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] xref: FMA:67780 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: CL:1000428 name: stem cell of epidermis def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] subset: cellxgene_subset synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis [Term] id: CL:1000443 name: ciliary muscle cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 xref: https://cellxgene.cziscience.com/cellguide/CL_1000443 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001775 ! ciliary body relationship: part_of UBERON:0001775 ! ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001366 ! parietal peritoneum relationship: part_of UBERON:0001366 ! parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] subset: human_reference_atlas xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001178 ! visceral peritoneum relationship: part_of UBERON:0001178 ! visceral peritoneum property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] xref: FMA:83386 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000488 name: cholangiocyte def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] subset: cellxgene_subset synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 xref: https://cellxgene.cziscience.com/cellguide/CL_1000488 is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0002394 ! bile duct relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002394 ! bile duct [Term] id: CL:1000490 name: mesothelial cell of peritoneum def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0002358 ! peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura def: "A mesothelial cell that is part of the pleura." [GOC:tfm] subset: cellxgene_subset synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 xref: https://cellxgene.cziscience.com/cellguide/CL_1000491 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002400 ! parietal pleura relationship: part_of UBERON:0002400 ! parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:86739 xref: https://cellxgene.cziscience.com/cellguide/CL_1000493 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0002401 ! visceral pleura property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000083 ! epithelial cell of pancreas intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001516 name: intestinal enteroendocrine cell def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] subset: cellxgene_subset xref: https://cellxgene.cziscience.com/cellguide/CL_1001516 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium relationship: develops_from CL:4052006 ! intestinal enteroendocrine progenitor relationship: develops_from UBERON:0000160 ! intestine relationship: develops_from UBERON:0001007 ! digestive system relationship: develops_from UBERON:0001242 ! intestinal mucosa relationship: develops_from UBERON:0001262 ! wall of intestine relationship: develops_from UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0001983 ! crypt of Lieberkuhn relationship: develops_from UBERON:0005409 ! alimentary part of gastrointestinal system relationship: develops_from UBERON:0011184 ! epithelium of crypt of Lieberkuhn relationship: directly_develops_from CL:4052006 ! intestinal enteroendocrine progenitor [Term] id: CL:1001517 name: stomach enteroendocrine cell def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." [MP:0010803] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach [Term] id: CL:1001567 name: lung endothelial cell def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000102 ! lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0005317 ! pulmonary artery endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001572 name: colon endothelial cell def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] synonym: "colon endothelial cells" RELATED OMO:0003004 [CALOHA:TS-2397] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] xref: CALOHA:TS-2397 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0013695 ! colon endothelium [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: part_of UBERON:0002424 ! oral epithelium [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] xref: CALOHA:TS-1274 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0001155 ! colon [Term] id: CL:1001589 name: duodenum secretory cell def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] subset: cellxgene_subset synonym: "duodenum glandular cells" NARROW [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1001592 name: gallbladder glandular cell def: "Glandular cell of gallbladder epithelium." [NPX:PDR] synonym: "gall bladder glandular cell" EXACT [FMA:7202] synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] xref: CALOHA:TS-1278 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:1000415 ! epithelial cell of gallbladder intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002029 ! epithelium of gall bladder [Term] id: CL:1001595 name: rectum glandular cell def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] xref: CALOHA:TS-1281 is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0003354 ! epithelium of rectum [Term] id: CL:1001598 name: small intestine secretory cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR] synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestinal glandular cell" NARROW [CALOHA:TS-1286] synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286] xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR] subset: human_reference_atlas synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242] synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242] xref: BTO:0000028 xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0001630 ! muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0012429 ! hematopoietic tissue [Term] id: CL:1100001 name: secretory epithelial cell def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172] is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 property_value: http://purl.org/dc/terms/date 2024-07-21T09:24:44Z xsd:dateTime [Term] id: CL:2000008 name: microvascular endothelial cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium relationship: part_of UBERON:0008339 ! microvascular endothelium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:07:42Z [Term] id: CL:2000010 name: dermis blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:12:06Z [Term] id: CL:2000013 name: fibroblast of skin of abdomen def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001416 ! skin of abdomen relationship: part_of UBERON:0001416 ! skin of abdomen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:18:16Z [Term] id: CL:2000016 name: lung microvascular endothelial cell def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T16:00:56Z [Term] id: CL:2000019 name: compound eye photoreceptor cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000018 ! compound eye relationship: part_of UBERON:0000018 ! compound eye property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:45Z [Term] id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000087 ! inner cell mass relationship: part_of UBERON:0000087 ! inner cell mass property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:53Z [Term] id: CL:2000022 name: cardiac septum cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0002099 ! cardiac septum relationship: part_of UBERON:0002099 ! cardiac septum property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000029 name: central nervous system neuron def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system relationship: RO:0002100 UBERON:0001017 ! has soma location central nervous system property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T01:17:43Z [Term] id: CL:2000032 name: peripheral nervous system neuron def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas synonym: "peripheral neuron" EXACT [] synonym: "PNS neuron" EXACT [] xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-06-25T02:28:17Z [Term] id: CL:2000042 name: embryonic fibroblast def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:12:00Z [Term] id: CL:2000044 name: brain microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:24:53Z [Term] id: CL:2000046 name: ventricular cardiac muscle cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] subset: cellxgene_subset xref: https://cellxgene.cziscience.com/cellguide/CL_2000046 is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 ! has soma location brainstem relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-02T23:52:53Z [Term] id: CL:2000051 name: splenic fibroblast def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T18:58:47Z [Term] id: CL:2000053 name: splenic endothelial cell def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 subset: human_reference_atlas is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-06T19:06:04Z [Term] id: CL:2000063 name: ovarian fibroblast def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 is_a: CL:0000057 ! fibroblast is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:57:42Z [Term] id: CL:2000064 name: ovarian surface epithelial cell def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 subset: cellxgene_subset is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:59:13Z [Term] id: CL:2000066 name: cardiac ventricle fibroblast def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 subset: human_reference_atlas is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-07T18:35:38Z [Term] id: CL:2000067 name: cardiac atrium fibroblast def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 subset: human_reference_atlas is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-07T18:36:54Z [Term] id: CL:2000068 name: pericardium fibroblast def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002407 ! pericardium relationship: part_of UBERON:0002407 ! pericardium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:38:06Z [Term] id: CL:2000069 name: gallbladder fibroblast def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:41:43Z [Term] id: CL:2000070 name: optic choroid fibroblast def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:50:43Z [Term] id: CL:2000072 name: adipose microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T22:13:45Z [Term] id: CL:2000073 name: migratory cardiac neural crest cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] synonym: "cardiac neural crest cell" EXACT [PMID:33060096] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: part_of UBERON:0000095 ! cardiac neural crest relationship: part_of UBERON:0000095 ! cardiac neural crest property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:18:43Z [Term] id: CL:2000074 name: splenocyte def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:26:50Z [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] synonym: "mesenchymal stem cell of abdominal adipose" EXACT [] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:10:34Z [Term] id: CL:2000093 name: bronchus fibroblast of lung def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-03-31T21:16:22Z [Term] id: CL:3000004 name: peripheral sensory neuron def: "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." [GOC:CellBLAST, https://www.britannica.com/science/sensory-neuron, https://www.ncbi.nlm.nih.gov/books/NBK539846/, PMID:30096314, PMID:31554486, PMID:35858549, Wikipedia:Sensory_neuron] comment: Typically, a sensory neuron has a pseudounipolar morphology. {xref="Wikipedia:Sensory_neuron"} is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-25T19:34:33Z [Term] id: CL:4023072 name: brain vascular cell def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0008998 ! vasculature of brain relationship: part_of UBERON:0008998 ! vasculature of brain property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas is_a: CL:2000029 ! central nervous system neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: develops_from UBERON:0001891 ! midbrain relationship: develops_from UBERON:0001891 ! midbrain property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023168 name: somatosensory neuron def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0003942 ! somatosensory system intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: part_of UBERON:0003942 ! somatosensory system property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4028001 name: pulmonary capillary endothelial cell def: "Any capillary endothelial cell that is part of a lung." [] synonym: "lung capillary endothelial cell" EXACT [] is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000016 ! lung microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0016405 ! pulmonary capillary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T02:31:40Z [Term] id: CL:4033002 name: neuroendocrine cell of epithelium of crypt of Lieberkuhn def: "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn." [PMID:31390635] is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033005 name: serous secreting cell of bronchus submucosal gland def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178] comment: The marker set PRR4, C6orf58 can identify the Human cell type serous secreting cell of bronchus submucosal gland in the Lung with a confidence of 0.75 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000152 ! exocrine cell is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland relationship: part_of UBERON:8410043 ! bronchus submucosal gland relationship: RO:0015004 CLM:1000054 ! has characterizing marker set property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033008 name: vein endothelial cell of respiratory system def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] subset: human_reference_atlas is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033018 name: lung megakaryocyte def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] subset: human_reference_atlas synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116] synonym: "lung resident megakaryocyte" EXACT [PMID:36524131] synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131] synonym: "MKL" RELATED OMO:0003000 [PMID:36524131] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000556 ! megakaryocyte intersection_of: part_of UBERON:0000114 ! lung connective tissue relationship: part_of UBERON:0000114 ! lung connective tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-9185-3994 property_value: http://purl.org/dc/terms/date 2023-03-16T11:31:23Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033020 name: mucus secreting cell of trachea gland def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [PMID:18931053, PMID:29656943] subset: human_reference_atlas synonym: "tracheal submucosal gland mucous cell" EXACT [PMID:18931053] is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland intersection_of: CL:0000319 ! mucus secreting cell intersection_of: part_of UBERON:0005203 ! trachea gland relationship: part_of UBERON:0005203 ! trachea gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-9185-3994 property_value: http://purl.org/dc/terms/date 2023-03-16T13:03:13Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033022 name: mucus secreting cell of bronchus submucosal gland def: "A mucus secreting cell of a submucosal gland of the bronchus." [PMID:19965983] comment: The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the Lung with a confidence of 0.93 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_reference_atlas synonym: "bronchial gland mucous cell" EXACT [PMID:5487122] is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland intersection_of: CL:0000319 ! mucus secreting cell intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland relationship: part_of UBERON:8410043 ! bronchus submucosal gland relationship: RO:0015004 CLM:1000053 ! has characterizing marker set property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-9185-3994 property_value: http://purl.org/dc/terms/date 2023-03-16T15:12:52Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033037 name: mucus secreting cell of tracheobronchial tree submucosal gland def: "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." [PMID:30864819] is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000319 ! mucus secreting cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree intersection_of: part_of UBERON:8410077 ! airway submucosal gland relationship: part_of UBERON:8410077 ! airway submucosal gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/date 2023-04-20T10:55:50Z xsd:dateTime [Term] id: CL:4033050 name: catecholaminergic neuron def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209] comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"} subset: human_reference_atlas is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0160043 ! catecholamine secretion, neurotransmission relationship: capable_of GO:0160043 ! catecholamine secretion, neurotransmission property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/date 2023-05-18T12:07:45Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033054 name: perivascular cell def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] subset: cellxgene_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: adjacent_to UBERON:0002049 ! vasculature relationship: adjacent_to UBERON:0002049 ! vasculature property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/date 2023-08-22T13:40:28Z xsd:dateTime [Term] id: CL:4033061 name: endothelial cell of central vein of liver def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163] synonym: "endothelial cell of central vein" BROAD [PMID:28287163] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0006841 ! central vein of liver relationship: part_of UBERON:0006841 ! central vein of liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033093 name: limbal epithelial stem cell of cornea def: "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." [PMID:20614614, PMID:29105366, PMID:36983561, PMID:37768272] synonym: "LESC" RELATED OMO:0003000 [PMID:20614614] synonym: "limbal epithelial stem cell" EXACT [PMID:20614614] synonym: "limbal stem cell" EXACT [PMID:17562792] synonym: "LSC" RELATED OMO:0003000 [PMID:36983561] is_a: CL:0000036 ! epithelial fate stem cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0006761 ! corneo-scleral junction relationship: develops_into CL:0000575 ! corneal epithelial cell relationship: part_of UBERON:0000482 ! basal lamina of epithelium relationship: part_of UBERON:0006761 ! corneo-scleral junction property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-7655-4833 property_value: http://purl.org/dc/terms/date 2024-12-11T13:59:19Z xsd:dateTime [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] synonym: "OAMSC" EXACT [PMID:31377878] synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878] synonym: "Orbital ASCs" EXACT [PMID:30210548] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: part_of UBERON:0004088 ! orbital region relationship: part_of UBERON:0004088 ! orbital region property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-0819-0473 property_value: http://purl.org/dc/terms/date 2023-09-18T10:43:00Z xsd:dateTime [Term] id: CL:4047023 name: intestinal lamina propria fibroblast def: "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin." [PMID:21252048, PMID:36032088] synonym: "S1 fibroblast" RELATED [PMID:30270042] is_a: CL:0000057 ! fibroblast is_a: CL:0000151 ! secretory cell intersection_of: CL:0000057 ! fibroblast intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion intersection_of: part_of UBERON:0004780 ! gastrointestinal system lamina propria relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion relationship: part_of UBERON:0004780 ! gastrointestinal system lamina propria property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0005-7919-4905 property_value: http://purl.org/dc/terms/date 2024-09-24T15:45:18Z xsd:dateTime [Term] id: CL:4047025 name: type G cell of stomach def: "Any type G enteroendocrine cell that is part of some epithelium of stomach." [FBC:Autogenerated] is_a: CL:0000508 ! type G enteroendocrine cell is_a: CL:1000222 ! stomach neuroendocrine cell intersection_of: CL:0000508 ! type G enteroendocrine cell intersection_of: part_of UBERON:0001276 ! epithelium of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0005-7919-4905 property_value: http://purl.org/dc/terms/date 2024-10-24T10:43:22Z xsd:dateTime [Term] id: CL:4052002 name: syncytial cell def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium] synonym: "SC" RELATED OMO:0003000 [PMID:9067520] synonym: "syncytium" EXACT [WBbt:0008074] is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000000 ! cell intersection_of: output_of GO:0000768 ! syncytium formation by plasma membrane fusion intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: output_of GO:0000768 ! syncytium formation by plasma membrane fusion property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-08-15T10:38:46Z xsd:dateTime [Term] id: CL:4052003 name: intestinal villus capillary endothelial cell def: "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier." [PMID:18480313, PMID:35810168, PMID:38051275] synonym: "villus blood capillary endothelial cells" BROAD [PMID:35810168] synonym: "villus tip endothelial cell" RELATED [PMID:38051275] is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0001213 ! intestinal villus relationship: part_of UBERON:0001213 ! intestinal villus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-09-17T10:03:25Z xsd:dateTime [Term] id: CL:4052006 name: intestinal enteroendocrine progenitor def: "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs." [doi:/10.1038/s41467-021-27901-5, PMID:31756561, PMID:32531023, PMID:35913117, PMID:38260422] comment: The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+. {xref="PMID:25670791"} synonym: "EEC Progenitor" RELATED OMO:0003000 [PMID:31756561] is_a: CL:0002563 ! intestinal epithelial cell is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0002250 ! intestinal crypt stem cell relationship: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-09-20T12:13:26Z xsd:dateTime [Term] id: CL:4052014 name: pancreatic islet capillary endothelial cell def: "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture." [PMID:16607697, PMID:27124642, PMID:28396983, PMID:33200981] synonym: "islet endothelial cell" BROAD [PMID:16607697, PMID:28396983] synonym: "pancreatic islet endothelial cell" BROAD [PMID:16607697] is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-09-30T14:36:12Z xsd:dateTime [Term] id: CL:4052015 name: endocrine gland capillary endothelial cell def: "Any capillary endothelial cell that is part of an endocrine gland." [PMID:18480313] is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0002368 ! endocrine gland relationship: part_of UBERON:0002368 ! endocrine gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-09-30T15:27:49Z xsd:dateTime [Term] id: CL:4052030 name: adventitial fibroblast def: "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" [PMID:28705796, PMID:36718802] comment: Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice. {xref="PMID:36718802"} is_a: CL:0000057 ! fibroblast is_a: CL:0000151 ! secretory cell is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel relationship: capable_of GO:0001816 ! cytokine production relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel property_value: http://purl.org/dc/terms/contributor https://orcid.org/0009-0000-8480-9277 property_value: http://purl.org/dc/terms/date 2024-12-05T11:01:15Z xsd:dateTime [Term] id: ECAO:00000000 name: root node [Term] id: ECAO:0000009 name: Life cycle [Term] id: ECAO:0000010 name: Life cycle phase def: "A temporal phase encompassing some part of the life cycle of an organism." [] relationship: part_of ECAO:0000009 ! Life cycle [Term] id: ECAO:0000020 name: gametogenesis phase def: "Biological process during which certain cells of a female or male individual (parent) are transformed into specialized reproductive cells (gametes) that will initiate development of a progeny individual (offspring) upon fertilization." [] relationship: part_of ECAO:0000010 ! Life cycle phase [Term] id: ECAO:0000030 name: oogenesis period def: "Period during which female gametes (or oocytes, or eggs) develop and mature from primordial female germ cells to generate cells competent to further development upon fertilization by a mature spermatozoid." [] synonym: "ovogenesis period" EXACT [] relationship: part_of ECAO:0000020 ! gametogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000040 name: previtellogenic primary oocyte stage def: "A female gamete that is small in size, i.e. about 10 microm in diameter, and that is at the previtellogenic stage." [] relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000050 name: not fully grown oocyte stage def: "A developing female gamete that started growing in size by accumulation of yolk proteins. At this stage, it is characterized by the presence of a large nucleus, the germinal vesicle, which contains a prominent nucleolus and occupies most of the cytoplasm." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000060 name: fully grown oocyte with centered germinal vesicle stage def: "A developing female gamete that has reached its full size. It has grown up to ten times its original size, i.e. 80 to 100microm. It also displays a large germinal vesicle that is centered, but it is still not competent for fertilization." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000050 ! not fully grown oocyte stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000070 name: fully grown oocyte with off-centered germinal vesicle stage def: "A developing female gamete that has reached its full size and in which the germinal vesicle has moved asymmetrically to the cell periphery. The germinal vesicle is now close to the animal pole." [] synonym: "primary oocyte" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000060 ! fully grown oocyte with centered germinal vesicle stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000080 name: fully grown oocyte with no nucleus stage def: "A developing female gamete in which the germinal vesicle has broken down. The germinal vesicle is no longer visible. However, the female gamete is still not mature. It is undergoing meiotic maturation, extruding successively a first and a second polar body." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000070 ! fully grown oocyte with off-centered germinal vesicle stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000090 name: mature oocyte stage def: "A mature female gamete that has achieved its meiotic maturation and in which the female pronucleus is visible. The mature oocyte is arrested in G1 phase and its average size is 80 to 100 µm. It is surrounded by a transparent jelly coat that is about 30 µm thick. It is competent to fertilization and it is located in the female gonad where it may be stored for weeks to months before its release in sea water by spawning. In the P. lividus species, the mature female gametes are characterized by the presence of pigment granules concentrated in a subequatorial band. This band is classically called the pigment band and allows to visualize the first embryonic axis, i.e. the animal-vegetal axis, which is perpendicular to the band." [] synonym: " spawned egg" EXACT [] synonym: "unfertilized egg" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000080 ! fully grown oocyte with no nucleus stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000100 name: spermatogenesis period def: "Period during which male gametes (or spermatozoa, or spermatozoid) develop and mature from primordial male germ cells to generate cells competent to further development upon fertilization of a mature oocyte." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000030 ! oogenesis period relationship: part_of ECAO:0000020 ! gametogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000110 name: developing spermatozoa stage def: "A developing, immature male gamete undergoing mitosis and meiosis to ultimately produce mature spermatozoa." [] synonym: "spermatid" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000090 ! mature oocyte stage relationship: part_of ECAO:0000100 ! spermatogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000120 name: mature spermatozoid stage def: "A mature male gamete that is composed of a head, encompassing a compact nucleus, a neck, a middle piece, and a tail (or flagellum) that propels it towards the oocyte upon spawning." [] synonym: " spermatozoa" EXACT [] synonym: "sperm" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000110 ! developing spermatozoa stage relationship: part_of ECAO:0000100 ! spermatogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000130 name: embryogenesis phase def: "The phase of the life cycle that begins with fertilization, continues with the formation and maturation of the embryo, and ends with the opening of the mouth, the onset of feeding, and the beginning of the growth of the organism." [] relationship: part_of ECAO:0000010 ! Life cycle phase [Term] id: ECAO:0000135 name: stage 1 def: "Fertilization has occurred but the zygote has not divided (1-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000100 ! spermatogenesis period relationship: part_of ECAO:0000130 ! embryogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000140 name: 1-cell stage def: "Fertilization has occurred, but the zygote has not undergone cell division. The embryo is a single diploid cell surrounded by a fertilization envelope" [] synonym: " fertilized egg" EXACT [] synonym: "zygote stage" EXACT [] xref: UBERON:0000106 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000100 ! spermatogenesis period relationship: part_of ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000150 name: cleavage period def: "The period that immediately follows fertilization and is characterized by rapid, synchronous mitotic cell divisions in the absence of cell growth. Cleavage culminates in the formation of a hollow, spherical, multicellular, monolayered embryo (a blastula) with a hollow cavity (the blastocoel) in the center." [] xref: UBERON:0000107 relationship: part_of ECAO:0000130 ! embryogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000155 name: stage 2 def: "The embryo is composed of 2 cells (2-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000135 ! stage 1 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000160 name: 2-cell stage def: "The embryo is composed of two cells and is surrounded by a fertilization envelope. The first cleavage division has taken place meridionally (i.e. along the animal-vegetal axis), thereby generating two blastomeres of equal size, each containing both animal and vegetal cytoplasm." [] synonym: "2c" EXACT [] xref: UBERON:0007232 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000140 ! 1-cell stage relationship: part_of ECAO:0000155 ! stage 2 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000165 name: stage 3 def: "The embryo is composed of 4 cells (4-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000155 ! stage 2 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000170 name: 4-cell stage def: "The embryo is composed of four cells and is surrounded by a fertilization envelope. The second cleavage division has taken place meridional and perpendicular to the first cleavage division. This has produced four blastomeres of equal size, all of which contain both animal and vegetal cytoplasm." [] synonym: "4c" EXACT [] xref: UBERON:0007233 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000160 ! 2-cell stage relationship: part_of ECAO:0000165 ! stage 3 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000175 name: stage 4 def: "The embryo is composed of 8 cells (8-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000165 ! stage 3 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000180 name: 8-cell stage def: "The embryo is composed of eight cells and is surrounded by a fertilization envelope. The third cleavage division has taken place equatorial and perpendicular to the first two cleavage divisions." [] synonym: "8c" EXACT [] xref: UBERON:0007236 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000170 ! 4-cell stage relationship: part_of ECAO:0000175 ! stage 4 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000185 name: stage 5 def: "The embryo is composed of 16 cells (16-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000175 ! stage 4 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000190 name: 16-cell stage def: "The embryo is composed of 16 cells and is surrounded by a fertilization envelope." [] synonym: "16c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000180 ! 8-cell stage relationship: part_of ECAO:0000185 ! stage 5 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000195 name: stage 6 def: "The embryo is composed of 28-32 cells (includes 28- and 32-cell stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000185 ! stage 5 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000200 name: 28-cell stage def: "The embryo is composed of 28 cells and is surrounded by a fertilization envelope. " [] synonym: "28c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000190 ! 16-cell stage relationship: part_of ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000210 name: 32-cell stage def: "The embryo is composed of 32 cells and is surrounded by a fertilization envelope. " [] synonym: "32c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000200 ! 28-cell stage relationship: part_of ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000215 name: stage 7 def: "The embryo is composed of 56-64 cells (includes 56-, 60-, and 64-cell stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000195 ! stage 6 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000220 name: 56-cell stage def: "The embryo is composed of 56 cells and is surrounded by a fertilization envelope." [] synonym: "56c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000230 name: 60-cell stage def: "The embryo is composed of 60 cells and is surrounded by a fertilization envelope." [] synonym: "60c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000220 ! 56-cell stage relationship: part_of ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000235 name: 64-cell stage def: "The embryo is composed of 64 cells and is surrounded by a fertilization envelope." [] synonym: "64c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000240 name: blastula period def: "The period that immediately follows cleavage and precedes gastrulation. It is characterized by the progressive maturation of the embryo into a hollow sphere, which is one cell layer thick and encompasses a central, fluid-filled cavity (the blastocoel). This period is associated with a gradual increase in cell cycle length and a loss of mitotic synchrony. During mitosis, cells round up and the wall of the blastula becomes irregular, while during interphase the cells flatten and the wall of the blastula appears smooth. During this period, the blastocoel gradually expands and becomes lined by a thin basal lamina. Cells in the wall of the blastula thereby become polarized; the inner (basal) surface of each cell contacts the basal lamina while the outer (apical) surface contacts the hyaline layer, an extracellular matrix that surrounds the embryo. Each cell further forms a single apical cilium. The onset of ciliary motility causes the blastula to move within the fertilization envelope and, after hatching, coordinated ciliary beating allows the embryo to swim freely. The blastula period culminates in the formation of the vegetal plate, a placode of elongated, presumptive endomesoderm cells. " [] xref: UBERON:0000307 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000150 ! cleavage period relationship: part_of ECAO:0000130 ! embryogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000250 name: very early blastula stage def: "The embryo is composed of about 100 cells and is surrounded by a fertilization envelope. All cells are about the same size and there are no obvious morphological indications of embryonic polarity or territories. The embryo has started to transform into a hollow sphere." [] synonym: " 120-cell stage" EXACT [] synonym: " B1" EXACT [] synonym: "vEB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000230 ! 60-cell stage relationship: part_of ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000255 name: stage 8 def: "The embryo is an early blastula (early blastula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000215 ! stage 7 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000260 name: early blastula stage def: "The embryo is composed of about 100-200 cells and is surrounded by a fertilization envelope. Most blastomeres have completed at least one additional mitotic division since the 60- or 64-cell stage. All cells are approximately the same size and there are no obvious morphological indications of the primary or secondary embryonic axes. All cells have begun to acquire an apical-basal polarity and the embryo is beginning to transform into a hollow sphere with a monolayered epithelial wall and a fluid-filled cavity (the blastocoel) in the center. " [] synonym: " B2" EXACT [] synonym: "EB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000250 ! very early blastula stage relationship: part_of ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000265 name: stage 9 def: "The embryo is a mid-blastula (includes mid-blastula and motile blastula stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000255 ! stage 8 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000270 name: mid-blastula stage def: "The embryo is composed of about 200-500 cells and is surrounded by a fertilization envelope. Most cells have completed at least one additional mitotic division since the early blastula stage. The cell divisions are now less synchronous than at earlier stages. The embryo remains spherical in shape and one cell layer thick. It does not display any morphological indications of the embryonic axes or of the vegetal plate. The cells have started to flatten on their inner (basal) surface, further contributing to the enlargement of the blastocoel, which has expanded since the early blastula stage." [] synonym: " B3" EXACT [] synonym: " midB" EXACT [] synonym: "mid-B" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000260 ! early blastula stage relationship: part_of ECAO:0000265 ! stage 9 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000275 name: stage 10 def: "The embryo is a late blastula, it is still spherical, and the vegetal plate has not formed (late blastula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000265 ! stage 9 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000280 name: late blastula stage def: "The embryo is composed of about 600-1000 cells. Most cells have completed at least one additional mitotic division since the mid-blastula stage and developed an apical cilium. The embryo is still spherical in shape and one cell layer thick. It still lacks obvious morphological landmarks of the embryonic axes and of the vegetal plate. Cells have further continued to flatten along the apical-basal axis, accentuating the enlargement of the blastocoel. They are also now joined to one another apically by septate and adherens junctions and laterally by desmosomes." [] synonym: " B4" EXACT [] synonym: " LB" EXACT [] synonym: " pre-HB" EXACT [] synonym: " prehatched blastula" EXACT [] synonym: "Late-B" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000270 ! mid-blastula stage relationship: part_of ECAO:0000275 ! stage 10 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000284 name: stage 11 def: "The embryo, whether or not hatched from the fertilization envelope, has formed a vegetal plate but gastrulation has not begun (vegetal plate stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000275 ! stage 10 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000286 name: stage 12 def: "The embryo has hatched from the fertilization envelope and is undergoing the earliest cell movements of gastrulation (includes early, mid-, and late mesenchyme blastula episodes and blastopore formation stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000284 ! stage 11 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000290 name: hatched blastula stage def: "The fertilization envelope has started to break down due to the secretion by ectodermal cells of the hatching enzyme, a metalloprotease that digests the fertilization envelope and frees the embryo. The embryo rotates within the envelope or swims away as soon as it is free.The vegetal plate has not formed. " [] synonym: " B5" EXACT [] synonym: " very late blastula stage" EXACT [] synonym: "HB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000300 name: swimming blastula stage def: "The embryo has hatched from the fertilization envelope and swims freely. It is still a hollow sphere that is one cell layer thick, but the cells constituting the vegetal plate (i.e. located at the vegetal pole) have started thickening along the apico-basal axis, thereby creating a morphological landmark that enables orienting the embryo along the animal-vegetal axis." [] synonym: "SB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000290 ! hatched blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000310 name: late swimming blastula stage def: "The embryo has started elongated along the animal-vegetal axis. Its vegetal region has further continued to thicken and it is marked by a characteristic 'V' shape formed by the blastocoel at the level of the cells constituting the vegetal plate, thereby pointing to the vegetal pole. " [] synonym: "late-SB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000300 ! swimming blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000320 name: gastrula period def: "The period that immediately follows the blastula period and precedes organogenesis. It is characterized by extensive movements of cells in the vegetal region of the embryo. This period culminates in the formation of a multilayered embryo composed of three primary germ layers (ectoderm, mesoderm, and endoderm). The cell movements of gastrulation include ingression of migratory, mesenchymal cells into the blastocoel and invagination of the vegetal plate that creates the primitive gut (archenteron). " [] xref: UBERON:0000109 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000240 ! blastula period relationship: part_of ECAO:0000130 ! embryogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000330 name: mesenchyme blastula episode def: "The first episode of the gastrulation period, characterized by the ingression into the blastocoel of the skeletogenic primary mesenchyme cells (PMCs), prior to the invagination of the vegetal plate." [] synonym: "MB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000320 ! gastrula period [Term] id: ECAO:0000340 name: early mesenchyme blastula episode def: "Skeletogenic primary mesenchyme cells (PMCs) are starting to ingress from the vegetal plate into the blastocoel through an epithelial–to-mesenchymal transition (EMT). " [] synonym: "eMB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000350 name: mid-mesenchyme blastula episode def: "Almost all skeletogenic primary mesenchyme cells (PMCs) have ingressed into the blastocoel and remain in a mound on the vegetal plate. " [] synonym: "mid-MB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000340 ! early mesenchyme blastula episode relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000360 name: late mesenchyme blastula episode def: "All skeletogenic primary mesenchyme cells (PMCs) have ingressed into the blastocoel. Many of these cells have extended filopodia and migrated away from the vegetal plate. The cells are found along the blastocoel wall, although they remain concentrated in the vegetal hemisphere of the embryo. The vegetal plate has flattened following the ingression of the PMCs. However, it has not started to invaginate. It is now composed at its center of the 8 small micromere descendants (the germ line) surrounded by non-skeletogenic mesoderm (NSM). " [] synonym: "late-MB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000350 ! mid-mesenchyme blastula episode relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000370 name: invagination episode def: "Period during which the inpocketing and elongation of the archenteron takes place." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000380 name: blastopore formation stage def: "The embryo is characterized morphologically by a slight invagination of the vegetal plate. This invagination has generated the anterior portion of the archenteron (primitive digestive tract) and the blastopore, an opening that will persist as the larval anus. " [] synonym: " blastopore gastrula stage" EXACT [] synonym: "blasto-G" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000360 ! late mesenchyme blastula episode relationship: part_of ECAO:0000710 ! invagination episode property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000385 name: stage 13 def: "The embryo is undergoing the first phase of archenteron extension (early gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000286 ! stage 12 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000390 name: early gastrula stage def: "The archenteron (primitive digestive tract) has elongated up to 1/3 of its final length. This elongation has occurred through the inward movement of all non-skeletogenic mesoderm (NSM) cells and part of the endoderm." [] synonym: " EG" EXACT [] synonym: "eG" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000380 ! blastopore formation stage relationship: part_of ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000395 name: stage 14 def: "The embryo is undergoing the middle phase of archenteron extension (mid-gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000385 ! stage 13 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000400 name: mid-gastrula stage def: "The archenteron (primitive digestive tract) has elongated to about half (1/3-2/3) of its final length. " [] synonym: " mid-G" EXACT [] synonym: "G" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0000395 ! stage 14 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000405 name: stage 15 def: "The embryo is undergoing the last phase of archenteron extension (late gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000395 ! stage 14 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000410 name: late gastrula stage def: "The archenteron (primitive digestive tract) has elongated up to more than 2/3 of its maximal length." [] synonym: " late-G" EXACT [] synonym: "LG" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000420 name: organogenesis period def: "The period that immediately follows the gastrula period. It is characterized by the progressive maturation of tissues and organs. This period culminates in the opening of the mouth. " [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000320 ! gastrula period relationship: part_of ECAO:0000130 ! embryogenesis phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000422 name: stage 16 def: "The embryo has completed archenteron elongation and mesenchyme cell ingression is complete (includes early prism and early organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000405 ! stage 15 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000424 name: stage 17 def: "The embryo has paired coelomic evaginations at the tip of the archenteron but lacks a stomodeal invagination and gut constrictions (includes late prism and mid-organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000422 ! stage 16 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000426 name: stage 18 def: "The embryo has paired coelomic pouches along with a stomodeal invagination and gut constrictions (includes late and very late organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000424 ! stage 17 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000428 name: stage 19 def: "The embryo has an open mouth (open mouth stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000426 ! stage 18 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000430 name: prism stage def: "The embryo is mainly characterized morphologically by a typical triangular shape, the beginning of the tripatition of the digestive tract and the presence of pigmented cells. The oral (or ventral) ectoderm has by now even more flattened, making an almost perfect right angle with the blastoporal side of the embryo. By contrast, on the opposite side, the aboral (or dorsal) ectoderm has round up and slightly elongated, thereby forming the primitive apex of the future larvae. These changes have conferred the embryo a typical and easy recognizable triangular shape. In the oral ectoderm, a small depression has further appeared, called the stomodeum, which will later fuse with the tip of the archenteron to form the mouth. In the blastocoel, the digestive tract has also by now bended toward the stomodeum and started to become tripartite. The cardiac sphincter has started forming, separating the future esophagus from the future stomach. The triradiate spicules have also continued elongating, thereby forming by now, towards the animal pole, the right and left dorsoventral connecting rods, towards the apex, the body rods, and along the vegetal, oral ectoderm the left and right ventral transverse rods. Moreover, some non-skeletogenic mesenchyme cells (or NSM cells, secondary mesenchyme cells or SMC) have started becoming pigmented and inserted into the aboral ectoderm. These cells represent part of the future immune system of the larvae along with other blastocoelar cells that are present in the blastocoel around the gut. In the vicinity of the future esophagus, other non-skeletogenic mesoderm descendant cells along with some endoderm cells have further arranged to form a single unpaired coelomic pouch. At the animal pole, the apical pole domain has also started to flatten making the embryo look like a square when viewed from the oral side, and it still arbors a tuft a long and immotile cilia. Finally, within the apical pole domain, but not yet in the ciliary band, molecular labeling surveys also start by this stage to reveal the presence of differentiating neuronal cells." [] synonym: " D" EXACT [] synonym: "Pr" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000710 ! invagination episode relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000440 name: larval development phase def: "The phase of the life cycle that begins when the mouth opens and the larva starts to feed, continues through the growth and maturation of the larva, and ends with metamorphosis." [] relationship: part_of ECAO:0000010 ! Life cycle phase [Term] id: ECAO:0000450 name: early feeding larva period def: "Biological process during which the specific outcome is the progression of a free-living larva before the development of the adult. Indirect development represents the mainstream developmental mode of metazoans. This process usually starts with the emergence of a larva that is planktonic and stops at the end of metamorphosis once the animal assumes adult characters." [] xref: UBERON:0000069 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ECAO:0000420 ! organogenesis period relationship: part_of GO:0002164 ! larval development property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000460 name: early pluteus larva stage def: "The embryo is by now a fully formed pluteus larva. The mouth has opened and the digestive tract is becoming functional. On the ventral side, the mouth is surrounded anteriorly by an oral hood and posteriorly by two postoral arms. On the dorsal side, the apex has lengthened. The skeleton has indeed continued extending, expending the dorsoventral connecting rods, the body rods, and the ventral transverse rods as well as developing the anterolateral rods and the postoral rods. Within the larva, the tripartition of the digestive tract has further progressed. The cardiac sphincter is now fully formed in between the esophagus and the stomach, and the pyloric sphincter in between the stomach and the intestine and the anal sphincter at the level of the anus have also started forming. Around the esophagus, the coelomic pouch has further developed into two bilobed sacs (or pouches), one on each side of the digestive tract. Finally, within the apical pole domain, as well as within the ciliary band, differentiated neurons with their extended axons can also now be distinguished by immunostaining. In parallel, the apical tuft of long and immotile cilia remains discernable at the tip of the oral hood, while in parallel the ciliary band has further started growing a concentrated number of intermediate size motile cilia, which will be used by the larva to swim directionally." [] synonym: " 2-arm pluteus stage" EXACT [] synonym: " early pluteus stage" EXACT [] synonym: "Eplut" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000430 ! prism stage relationship: part_of ECAO:0000450 ! early feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000470 name: 4-arm pluteus larva stage def: "The larva is characterized by the presence, on the ventral side, of four extended arms (two anterolateral arms at the level of the oral hood and two postoral arms) and on the dorsal side by a sleeked apex. The larva now possesses a completely tripartite and functional digestive tract composed of an esophagus, a stomach, and an intestine, respectively limited by a cardiac sphincter, a pyloric sphincter, and an anal sphincter. " [] synonym: " P" EXACT [] synonym: " Plut" EXACT [] synonym: " Plut4a" EXACT [] synonym: " pluteus larva" EXACT [] synonym: "Pluteus" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000480 name: late feeding larva period def: "To be written" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000450 ! early feeding larva period relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000490 name: 6-arm pluteus larva stage def: "The larva is characterized by the presence on the ventral side of six arms, and by the development, on the anterior midline of the esophagus, of the dorsal arch. " [] synonym: "Plut6a" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000500 name: 8-arm pluteus larva stage def: "The larva is characterized by the presence on the ventral side of eight arms and by the development within the larva, on the left side of the stomach, of the adult rudiment. This stage is relatively long. It includes distinct changes occurring to the larva as well as within the larva, although the larva consistently exhibits 8 arms. " [] synonym: "Plut8a" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000510 name: competent pluteus larva stage def: "The competent pluteus larva is characterized by the presence, within the larva, on the left side of its stomach, of the adult rudiment. The rudiment is now the size of or even bigger than the stomach and harbors five long primary podia (i.e. tube feet) and five quartets of definitive spines. Under the right environemental cue, the larva is competent to undergo metamorphosis. " [] synonym: " Cpt8a" EXACT [] synonym: "cPlut" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000520 name: metamorphic larva stage def: "The metamorphic larva stage is essentially when the larva undergoes metamorphsis. The larva goes through drastic morphological changes to transofrm the bilateral, planctonic larva into a benthic, pentaradial juvenile. " [] synonym: " meta" EXACT [] synonym: "metamorphosis" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0000440 ! larval development phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000530 name: adulthood phase def: "The phase of the life cycle that begins after metamorphosis, continues through the growth and maturation of the juvenile, and culminates in the formation of a sexually mature adult that produces functional gametes" [] relationship: part_of ECAO:0000010 ! Life cycle phase [Term] id: ECAO:0000540 name: juvenile period def: "Period during which a young benthic individual, posing as a small adult, grows but remains unable to reproduce." [] xref: UBERON:0034919 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000480 ! late feeding larva period relationship: part_of ECAO:0000530 ! adulthood phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000550 name: early juvenile stage def: "The early juvenile is morphologically similar to a miniature sea urchin adult. It harbors primary podia (or tube feet) and definitive spines, along with other appendages (e.g., immature spines, pedicellariae). Compare to the adult, however, it is smaller in size, deprived of a functional digestive system, and is sexually immature. " [] synonym: " endotrophic juvenile" EXACT [] synonym: " postlarva" EXACT [] synonym: "PLJuv" EXACT [] xref: UBERON:0007021 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000520 ! metamorphic larva stage relationship: part_of ECAO:0000540 ! juvenile period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000560 name: late juvenile stage def: "The late juvenile still looks like a small adult. Its digestive tract is now functional. However, the late juvenile remains sexually immature." [] synonym: "ExJuv" EXACT [] xref: UBERON:0007021 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0000540 ! juvenile period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000570 name: adult period def: "Period during which the animal reaches sexual maturity." [] xref: UBERON:0000066 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000540 ! juvenile period relationship: part_of ECAO:0000530 ! adulthood phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000580 name: adult stage def: "The adult stage corresponds to a fully formed pentaradial sea urchin individual that has reached sexual maturity. The gonads have developed within the perivisceral cavity and are connected to the outside by the genital pores pierced into the genital plates. " [] synonym: " gravid sea urchin" EXACT [] synonym: "sexual mature sea urchin" EXACT [] xref: UBERON:0000113 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0000570 ! adult period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000590 name: very late blastula stage def: "The embryo is composed of about 800 cells and is surrounded by a fertilization envelope. The wall of the embryo is thinner and smoother than at previous stages. The vegetal plate has not formed. Many cells are ciliated but the embryo has not begun to rotate within the fertilization envelope. Note for euechinoid indirect developers: molecular labeling typically indicates the presence of 32 large micromere descendants and 4 small micromere descendants at this stage." [] synonym: "vLB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000310 ! late swimming blastula stage relationship: part_of ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000600 name: vegetal plate stage def: "The embryo now displays a vegetal epithelial placode, the vegetal plate, that formed at the vegetal pole and thereby provides the first morphological indication of the animal-vegetal axis of the blastula. All cells have developed an apical cilium, although the embryo may or may not have hatched from the fertilization envelope." [] synonym: "VP" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000284 ! stage 11 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000610 name: open mouth stage def: "This stage is characterized by the opening of the mouth. The right and left coelomic pouches are prominent and well-separated from the foregut by narrow coelomic constrictions. Pronounced cardiac and developing pyloric constrictions (separating respectively the foregut and midgut, and the midgut and hindgut) are visible; the gut is thus visibly tripartite. The developing stomach (former midgut) is enlarged relative to the other segments of the gut and muscle bands surrounding the esophagus are apparent. The ciliary band(s) is (are) also discernable." [] synonym: " early pluteus stage" EXACT [] synonym: "2-arm stage" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000620 name: early prism stage def: "The embryo has a distinctive, angular shape due to the elongation of the skeletal rods. The body rods have elongated toward the apex (posterior end) of the embryo. The dorsoventral connecting rods are elongated, and the postoral rods are still very short although they already support thickened regions of ectoderm that will later form the distal tip of the postoral arms. The archenteron tip is slightly expanded, and its oral surface is directed toward the oral ectoderm. Ingression of secondary mesenchyme cells (SMCs) is complete. The embryo is reddish in color due to the presence of pigment cells within the aboral ectoderm. The animal pole domain (or apical plate) is prominent and the lateral walls of the embryo have thinned. The coelomic pouches and gut constrictions have not yet appeared." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000630 name: late prism stage def: "The embryo has a distinctive, angular shape due to the elongation of the skeletal rods. The body rods have expended even further compared to earlier stages and the postoral rods support short postoral arm buds. The anterior ends of the dorsoventral connecting rods are also now branched or bent. The archenteron tip is still bent toward the oral ectoderm. At the tip of the archenteron coelomic evaginations start to be apparent, although no gut constrictions are visible yet. The embryo is reddish in color due to the presence of pigment cells within the aboral ectoderm. The animal pole domain is prominent, and it still bears long, immotile cilia. " [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000640 name: early pluteus stage def: "early pluteus stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000630 ! late prism stage relationship: part_of ECAO:0000450 ! early feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000650 name: early organogenesis stage def: "The embryo is elongated along the animal-vegetal axis and has thus a characteristic oblong shape. The archenteron is fully extended, even though it still does not reach the blastocoel roof. The tip of the archenteron is enlarged, rounded, and smooth, and the archenteron has begun to deflect orally. Mesenchyme cell ingression is complete. However, paired coelomic pouches and gut constrictions have not yet formed." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000660 name: mid-organogenesis stage def: "The embryo is elongated along the animal-vegetal axis and has thus a characteristic oblong shape. The archenteron is overall deflected orally and its tip is enlarged, rounded, and smooth. The tip of the archenteron is further starting to display filopodia that interact with the ectoderm site where the mouth will form. At the tip of the archenteron, unpaired evaginations of the coelom are also now apparent, even though the stomodeal invagination, gut constrictions, and ciliary band(s) are still not discernable. Mesenchyme cells have dispersed through the blastocoel. " [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000650 ! early organogenesis stage relationship: part_of ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000670 name: late organogenesis stage def: "The embryo is characterized by the presence, at the tip of the archenteron, of two well-formed coelomic pouches, separated from the foregut by pronounced constrictions. The cardiac constriction, which separates the foregut and the midgut, has started to form. On the oral side of the embryo, the stomodeal invagination is visible, although the mouth has not yet opened. The ciliary band(s) is (are) not yet visible." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000660 ! mid-organogenesis stage relationship: part_of ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000680 name: very late organogenesis stage def: "The embryo displays prominent right and left anterior coelomic pouches, and the posterior enterocoel has enlarged. Pronounced cardiac and developing pyloric constrictions (separating respectively the foregut and midgut, and the midgut and hindgut) are formed, and the gut is thus visibly tripartite, with the posterior enterocoel projecting from the developing stomach (former midgut). The wall of the left anterior coelom is distended at both its anterior and posterior margins, where strands of cells extend to the ectoderm. Muscle bands surrounding the esophagus are apparent. Ridges of thickened ectoderm mark the positions of the future ciliary bands." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000670 ! late organogenesis stage relationship: part_of ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000690 name: mesenchyme blastula phase def: "mesenchyme blastula episode" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000700 name: motile blastula stage def: "The embryo is composed of 400-500 cells and is no longer surrounded by a fertilization envelope. Most cells have completed at least one additional mitotic division after the early blastula stage and the cell divisions are now less synchronous than at earlier stages. The embryo remains spherical in shape and one cell layer thick. It does not display any morphological indications of the embryonic axes or of the vegetal plate. The cells have started to flatten on their inner (basal) surface, further contributing to the enlargement of the blastocoel, which has expanded since the early blastula stage." [] synonym: "MotB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000265 ! stage 9 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000710 name: invagination episode def: "The second episode of the gastrulation period, characterized by the invagination of the vegetal plate into the blastocoel to form the primitive digestive tract (archenteron). " [] is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0103500 name: echinoderm anatomy def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [] xref: UBERON:0001062 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103510 name: anatomical structure def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome" [] xref: UBERON:0000061 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103520 name: anatomical system def: "A system that has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity. Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function" [] synonym: " body system" EXACT [] synonym: " connected anatomical system" EXACT [] synonym: "organ system" EXACT [] xref: UBERON:0000467 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103530 name: anatomical region def: "A region of the whole organism without well-defined compartmental boundaries" [] synonym: "organism subdivision" EXACT [] xref: UBERON:0000475 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103540 name: anatomical space xref: UBERON:0000464 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103550 name: whole organism def: "Anatomical structure that is an individual member of a species and consists of one cell or more" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103560 name: multicellular organism def: "Anatomical structure that is an individual member of a species and consists of more than one cell" [] xref: UBERON:0000468 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000155 ! stage 2 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103570 name: embryo def: "Anatomical entity that comprises the animal in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems" [] xref: UBERON:0000922 is_a: ECAO:0103560 ! multicellular organism relationship: existence_ends_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103580 name: larva xref: UBERON:0002548 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103570 ! embryo relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103590 name: juvenile xref: UBERON:0034919 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103580 ! larva relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103600 name: adult xref: UBERON:0007023 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103590 ! juvenile relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103610 name: digestive system def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [] xref: UBERON:0001007 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103620 name: embryonic digestive system def: "The gastrointestinal tract that is being formed during embryonic development starting with the formation of the primitive gut tube (or archenteron)" [] is_a: ECAO:0103610 ! digestive system relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000380 ! blastopore formation stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103630 name: larval digestive system def: "Organ system responsible for the food uptake and processing in the larva" [] is_a: ECAO:0103610 ! digestive system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103620 ! embryonic digestive system relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103640 name: juvenile digestive system is_a: ECAO:0103610 ! digestive system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103650 name: adult digestive system def: "Anatomical system that processes ingested substances in the adult" [] is_a: ECAO:0103610 ! digestive system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103640 ! juvenile digestive system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103660 name: immune system xref: UBERON:0002405 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103670 name: embryonic immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103680 name: larval immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103690 name: juvenile immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103700 name: adult immune system is_a: ECAO:0103660 ! immune system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103710 name: reproductive system def: "Anatomical system that has as its parts the organs concerned with reproduction, i.e. the male and female gonads." [] xref: UBERON:0000990 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103720 name: nervous system xref: UBERON:0001016 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103730 name: embryonic nervous system def: "The sum of all the structures in the embryo that will develop into the larval nervous system" [] is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103740 name: larval nervous system def: "The sum of all the neural structures present in the larva" [] is_a: ECAO:0103720 ! nervous system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103730 ! embryonic nervous system relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103750 name: juvenile nervous system is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103760 name: adult nervous system xref: UBERON:6003559 is_a: ECAO:0103720 ! nervous system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103750 ! juvenile nervous system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103770 name: muscular system xref: UBERON:0000383 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103780 name: larval muscular system is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103790 name: juvenile muscular system is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103800 name: adult muscular system xref: UBERON:6003218 is_a: ECAO:0103770 ! muscular system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103790 ! juvenile muscular system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103810 name: endoskeleton def: "Internal support structure of an animal composed of mineralized tissue. It gives shape, support and protection to the body." [] xref: UBERON:0001434 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103820 name: embryonic endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103830 name: larval endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103840 name: rudiment endoskeleton synonym: "skeletal rudiment" EXACT [] is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103850 name: juvenile endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103860 name: adult endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103870 name: water vascular system def: "The water vascular system is a hydraulic system used by sea urchins for locomotion, food and waste transportation, and respiration. The system is composed of canals connecting numerous tube feet." [] xref: UBERON:0008251 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103880 name: hemal system def: "The hemal system contains the blood. It is composed of a complex network of vessels mainly located around the gut." [] synonym: "haemal system" EXACT [] is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103890 name: animal hemisphere def: "Anatomical region that corresponds to the upper half of the embryo, which later is composed of the mesomeres, and ultimately encompasses the presumptive ectoderm" [] synonym: " upper half" EXACT [] synonym: " upper hemisphere" EXACT [] synonym: "animal half" EXACT [] xref: UBERON:0012284 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103900 name: vegetal hemisphere def: "Anatomical region that corresponds to the lower half of the embryo, which later is composed of the macromeres and the micromeres, and ultimately encompasses the endoderm and mesoderm" [] synonym: " lower half" EXACT [] synonym: " lower hemisphere" EXACT [] synonym: "vegetal half" EXACT [] xref: UBERON:0012285 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103910 name: cell cortex is_a: ECAO:0104040 ! cell part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103920 name: cleavage furrow is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103930 name: animal cortex def: "Cell component comprising the outermost layer of the animal region of the oocyte. It consists of a phospholipid bilayer and associated proteins" [] is_a: ECAO:0103910 ! cell cortex relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103940 name: vegetal cortex def: "Cell component comprising the outermost layer of the vegetal region of the oocyte. It consists of a phospholipid bilayer and associated proteins" [] is_a: ECAO:0103910 ! cell cortex relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103950 name: animal pole def: "The apical region of the animal hemisphere" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103960 name: vegetal pole def: "The apical most region of the vegetal hemisphere. Once cleavages have started the vegetal pole is characterized by the presence of the micromeres initially and then that of the small micromeres" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103970 name: animal pole domain synonym: " animal plate" EXACT [] synonym: " anterior neuroectoderm" EXACT [] synonym: " apical plate" EXACT [] synonym: " neurogenic ectoderm" EXACT [] synonym: "apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000250 ! very early blastula stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103980 name: blastopore xref: UBERON:0000100 is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103620 ! embryonic digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103990 name: blastopore lip xref: UBERON:3010455 is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103980 ! blastopore property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104000 name: bottle cell is_a: ECAO:0104010 ! embryonic cell relationship: existence_ends_during ECAO:0000286 ! stage 12 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104010 name: embryonic cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000155 ! stage 2 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104020 name: vegetal plate is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000286 ! stage 12 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104030 name: cell def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane" [] is_a: ECAO:0103510 ! anatomical structure property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104040 name: cell part def: "Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104050 name: digestive system element def: "Any of the organs or elements that are part of the digestive system" [] xref: UBERON:0013765 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104060 name: skeletal element xref: UBERON:0004765 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104070 name: embryonic structure def: "Any anatomical structure that is part of an embryo" [] xref: UBERON:0002050 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104080 name: larval structure def: "Any anatomical structure that is part of a larva" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104090 name: juvenile structure def: "Any anatomical structure that is part of a juvenile" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104100 name: adult structure def: "Any anatomical structure that is part of an adult" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104110 name: tissue xref: UBERON:0000479 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104120 name: rudiment synonym: " imaginal adult rudiment" EXACT [] synonym: "adult rudiment" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104130 name: rudiment structure is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104140 name: non-rudiment adult structure is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104147 name: intracellular part is_a: ECAO:0104040 ! cell part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104148 name: cytoskeleton is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104150 name: microtubule is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104160 name: nucleus def: "A membrane-bounded organelle of in which chromosomes are housed and replicated. In most cells, it contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some specialized cell types, RNA metabolism or DNA replication may be absent" [] is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104168 name: oocyte def: "A female haploid germ cell." [] is_a: ECAO:0104580 ! gamete relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104170 name: germinal vesicle def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity" [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104180 name: equatorial pigment band def: "The subequatorial accumulation of pigment granules (the so-called ‘pigment band’) in eggs or early stage embryos, which constitutes an unambiguous marker of animal-vegetal polarity" [] synonym: " pigmented band" EXACT [] synonym: "pigment band" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104190 name: cytoplasm def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures" [] is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104200 name: centrosome is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104210 name: mitotic spindle is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104220 name: meiotic spindle is_a: ECAO:0104147 ! intracellular part relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104230 name: fertilization envelope def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release" [] synonym: "fertilization membrane" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104247 name: spermatozoid def: "A mature male germ cell" [] synonym: " male gamete" EXACT [] synonym: " mature sperm cell" EXACT [] synonym: " spermatozoa" EXACT [] synonym: " spermatozoan" EXACT [] synonym: "sperm" EXACT [] is_a: ECAO:0104580 ! gamete relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104248 name: aster synonym: " mitotic aster" EXACT [] synonym: "spindle aster" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104250 name: sperm aster synonym: "spermatozoid aster" EXACT [] is_a: ECAO:0104248 ! aster relationship: existence_ends_during ECAO:0000120 ! mature spermatozoid stage relationship: existence_starts_during ECAO:0000120 ! mature spermatozoid stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104270 name: acellular membrane xref: UBERON:0005764 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000090 ! mature oocyte stage relationship: existence_starts_during ECAO:0000090 ! mature oocyte stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104280 name: vitelline membrane synonym: " vitelline envelope" EXACT [] synonym: "vitelline layer" EXACT [] xref: UBERON:0003125 is_a: ECAO:0104270 ! acellular membrane relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104300 name: hyaline layer synonym: "hyaline membrane" EXACT [] is_a: ECAO:0104270 ! acellular membrane relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104310 name: microvillus is_a: ECAO:0104040 ! cell part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104320 name: apical lamina synonym: "fibropellin layer" EXACT [] is_a: ECAO:0104270 ! acellular membrane relationship: part_of ECAO:0104300 ! hyaline layer property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104330 name: secretory vesicle is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104340 name: cilium is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104350 name: filopodium is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104360 name: basal lamina xref: UBERON:0000482 is_a: ECAO:0104270 ! acellular membrane relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104370 name: basal laminar vesicle synonym: " basal vesicle" EXACT [] synonym: "basal lamina vesicle" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104380 name: apical vesicle is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104390 name: cortical granule synonym: "cortical vesicle" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104400 name: echinonectin vesicle synonym: " echinonectin granule" EXACT [] synonym: "nectosome" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104410 name: mitochondrion is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104420 name: actin cytoskeleton is_a: ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104430 name: actin filament synonym: " F-actin filament" EXACT [] synonym: "microfilament" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104420 ! actin cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104440 name: nuclear part is_a: ECAO:0104147 ! intracellular part relationship: existence_starts_during ECAO:0000090 ! mature oocyte stage relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104450 name: nucleoplasm is_a: ECAO:0104440 ! nuclear part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104460 name: nuclear envelope is_a: ECAO:0104440 ! nuclear part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104470 name: endoplasmic reticulum is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104480 name: spermatozoid entry point is_a: ECAO:0104040 ! cell part relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104490 name: plasma membrane synonym: "cell membrane" EXACT [] is_a: ECAO:0104040 ! cell part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104500 name: polar body def: "A small cell formed by the meiotic division of an oocyte" [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104510 name: spermatozoid part synonym: "sperm part" EXACT [] is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104520 name: spermatozoid head def: "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome." [] is_a: ECAO:0104510 ! spermatozoid part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104530 name: spermatozoid flagellum def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid" [] synonym: "sperm tail" EXACT [] is_a: ECAO:0104510 ! spermatozoid part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104540 name: acrosomal vesicle def: "An organelle that develops over the anterior half of the head in the spermatozoa" [] synonym: "acrosome" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104520 ! spermatozoid head property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104548 name: small micromere descendant cell synonym: "presumptive primordial germ cell" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104720 ! small micromere relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104550 name: presumptive primordial germ cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104548 ! small micromere descendant cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104560 name: primordial germ cell is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104570 name: germ cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104580 name: gamete is_a: ECAO:0104570 ! germ cell relationship: existence_ends_during ECAO:0000020 ! gametogenesis phase relationship: existence_starts_during ECAO:0000020 ! gametogenesis phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104600 name: immature occyte synonym: "immature egg" EXACT [] is_a: ECAO:0104168 ! oocyte relationship: existence_ends_during ECAO:0000080 ! fully grown oocyte with no nucleus stage relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0104560 ! primordial germ cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104610 name: mature oocyte def: "A mature female gamet that has entered meiosis." [] synonym: " female gamete" EXACT [] synonym: " female germ cell" EXACT [] synonym: " unfertilized egg" EXACT [] synonym: "egg" EXACT [] is_a: ECAO:0104168 ! oocyte relationship: develops_from ECAO:0104600 ! immature occyte relationship: part_of ECAO:0104570 ! germ cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104630 name: blastomere def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)" [] synonym: "blastoderm cell" EXACT [] is_a: ECAO:0104010 ! embryonic cell relationship: existence_ends_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104640 name: blastomere of 2-cell embryo is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000160 ! 2-cell stage relationship: existence_starts_during ECAO:0000160 ! 2-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104650 name: blastomere of 4-cell embryo is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000170 ! 4-cell stage relationship: existence_starts_during ECAO:0000170 ! 4-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104660 name: mesomere def: "Intermediate size blastomere forming the animal hemisphere of the cleaving embryo" [] synonym: "mesomeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000185 ! stage 5 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104670 name: macromere def: "Larger blastomere of the vegetal hemisphere of the cleaving embryo located below the equator" [] synonym: "macromeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000185 ! stage 5 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104678 name: cell tier synonym: "blastomere tier" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000175 ! stage 4 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104680 name: macromere daughter cell tier is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000195 ! stage 6 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104690 name: micromere def: "Small blastomere of the vegetal hemisphere of the cleaving embryo located at to the vegetal pole" [] synonym: "micromeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000195 ! stage 6 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104700 name: large micromere is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104690 ! micromere relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104710 name: large micromere descendant cell synonym: " presumptive PMC" EXACT [] synonym: " presumptive primary mesenchyme cell" EXACT [] synonym: " presumptive skeletogenic mesenchyme cell" EXACT [] synonym: "large micromere progeny" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104720 name: small micromere synonym: "SM" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104690 ! micromere relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104740 name: presumptive neuron def: "A progenitor cell of the nervous system that will develop into a neuron" [] synonym: "neuronal progenitor cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104750 name: animal pole domain presumptive neuron synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104760 name: ectoderm presumptive neuron synonym: "ectoderm neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104770 name: ciliary band presumptive neuron synonym: "ciliary band neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104780 name: endoderm associated presumptive neuron synonym: "endoderm associated neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104790 name: neuron synonym: "nerve cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104740 ! presumptive neuron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104800 name: larval neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104810 name: serotonergic neuron is_a: ECAO:0104790 ! neuron relationship: develops_from ECAO:0104750 ! animal pole domain presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104820 name: synaptotagmin-B neuron is_a: ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104830 name: dopaminergic neuron is_a: ECAO:0104790 ! neuron relationship: develops_from ECAO:0104760 ! ectoderm presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104840 name: GABAergic neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104850 name: sensory neuron synonym: "sensory cell" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104860 name: biopolar neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104870 name: multipolar neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104878 name: neural structure synonym: "neuronal structure" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104880 name: axon tract synonym: " axon bundle" EXACT [] synonym: "axonal tract" EXACT [] xref: UBERON:0001018 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104900 name: ciliary band neuron synonym: "peripheral neuron" EXACT [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104770 ! ciliary band presumptive neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104908 name: ectoderm def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [] xref: UBERON:0000924 is_a: ECAO:0105150 ! germ layer property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104910 name: presumptive ciliary band cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000422 ! stage 16 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104920 name: endoderm associated neuron is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104780 ! endoderm associated presumptive neuron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104930 name: ganglion xref: UBERON:0000045 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104940 name: apical ganglion synonym: "apical organ" EXACT [] is_a: ECAO:0104930 ! ganglion is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103970 ! animal pole domain relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104950 name: adult neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104960 name: circumoral nerve ring is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104970 name: enteric nerve plexus synonym: " digestive nerve plexus" EXACT [] synonym: "enteric plexus" EXACT [] xref: UBERON:0000429 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104980 name: radial nerve cord is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104990 name: primary podia associated neuron is_a: ECAO:0104950 ! adult neuron relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105000 name: secondary podia associated neuron is_a: ECAO:0104950 ! adult neuron relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105010 name: definitive spine associated neuron is_a: ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105020 name: pedicellaria associated neuron is_a: ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105030 name: basiepidermal nerve plexus is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105050 name: animal quartet def: "Group of four cells of equal size forming the animal hemisphere of an eight-cell stage embryo" [] is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105060 name: vegetal quartet def: "Group of four cells of equal size forming the vegetal hemisphere of an eight-cell stage embryo" [] is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105070 name: animal tier 1 synonym: "an1" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105080 name: animal tier 2 synonym: "an2" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105090 name: vegetal tier 1 synonym: " ectoendoderm" EXACT [] synonym: "veg1" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000255 ! stage 8 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105100 name: vegetal tier 2 synonym: " endomesoderm" EXACT [] synonym: "veg2" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000255 ! stage 8 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105110 name: vegetal tier 1 upper synonym: " presumptive vegetal ectoderm" EXACT [] synonym: " veg1 upper" EXACT [] synonym: "veg1U" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105120 name: vegetal tier 1 lower synonym: " veg1 lower" EXACT [] synonym: "veg1L" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105130 name: vegetal tier 2 upper synonym: " veg2 upper" EXACT [] synonym: "veg2U" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105140 name: vegetal tier 2 lower synonym: " presumptive non-skeletogenic mesoderm" EXACT [] synonym: " veg2 lower" EXACT [] synonym: "veg2L" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105150 name: germ layer synonym: " embryonic germ layer" EXACT [] synonym: "primary germ layer" EXACT [] xref: UBERON:0000923 is_a: ECAO:0104070 ! embryonic structure relationship: existence_starts_during ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105158 name: embryonic tissue xref: UBERON:0005291 is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105160 name: presumptive ectoderm xref: UBERON:0006601 is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105180 name: animal ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105190 name: vegetal ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000600 ! vegetal plate stage relationship: existence_starts_during ECAO:0000260 ! early blastula stage relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105200 name: ventral ectoderm synonym: "oral ectoderm" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105210 name: dorsal ectoderm synonym: "aboral ectoderm" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105220 name: ectoendoderm synonym: " veg1" EXACT [] synonym: "vegetal tier 1" EXACT [] is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105230 name: endomesoderm synonym: " mesoendoderm" EXACT [] synonym: " veg2" EXACT [] synonym: "vegetal tier 2" EXACT [] is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105240 name: inner animal pole domain synonym: "inner apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105250 name: outer animal pole domain synonym: "outer apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105260 name: central ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105270 name: border ectoderm synonym: "BE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105280 name: near-apical ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000710 ! invagination episode relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105290 name: apical ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105300 name: veg1-lateral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000710 ! invagination episode relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105310 name: veg-1 oral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000710 ! invagination episode relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105320 name: lateral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105330 name: right lateral ectoderm is_a: ECAO:0105320 ! lateral ectoderm relationship: existence_ends_during ECAO:0000710 ! invagination episode relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105340 name: left lateral ectoderm is_a: ECAO:0105320 ! lateral ectoderm relationship: existence_ends_during ECAO:0000710 ! invagination episode relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105350 name: arm tip ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105360 name: dorsal arm tip ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105370 name: ventral arm tip ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105380 name: apical tuft is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105400 name: larval tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105410 name: rudiment tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105420 name: juvenile tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105430 name: adult tissue is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105440 name: presumptive stomodeum is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105450 name: stomodeum synonym: "presumptive mouth" EXACT [] xref: UBERON:0000930 is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105440 ! presumptive stomodeum relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105460 name: ciliary band is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105470 name: oral hood ciliary band is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105480 name: arm ciliary band is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105490 name: animal pole ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105500 name: vegetal ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105510 name: lateral ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105520 name: oral hood synonym: " PL" EXACT [] synonym: " preoral lobe" EXACT [] synonym: "oh" EXACT [] is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105530 name: apex is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105540 name: larval arm is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105550 name: right anterolateral arm synonym: " ALA" EXACT [] synonym: "AL" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105560 name: left anterolateral arm synonym: " ALA" EXACT [] synonym: "AL" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105570 name: right postoral arm synonym: "PO" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105580 name: left postoral arm synonym: "PO" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105590 name: right posterodorsal arm synonym: "PD" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105600 name: left posterodorsal arm synonym: "PD" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105610 name: right preoral arm synonym: " PRO" EXACT [] synonym: "PR" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105620 name: left preoral arm synonym: " PRO" EXACT [] synonym: "PR" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105628 name: spicule rudiment is_a: ECAO:0104060 ! skeletal element property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105630 name: spicule granule synonym: "spicule dot" EXACT [] is_a: ECAO:0105628 ! spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105650 name: triradiate spicule rudiment synonym: "spicule primordium" EXACT [] is_a: ECAO:0105628 ! spicule rudiment is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105660 name: right ventrolateral triradiate spicule rudiment synonym: "triradiate spicule" EXACT [] is_a: ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105670 name: left ventrolateral triradiate spicule rudiment is_a: ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105680 name: hexaradiate spicule rudiment synonym: "hexaradiate spicule" EXACT [] is_a: ECAO:0105628 ! spicule rudiment is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105690 name: larval spicule def: "A triradiate or hexaradiate minute calcareous skeletal element that initiates most if not all skeletal structures found within the sea urchin embryo, larva and adult." [] synonym: "primary triradiate skeletal rudiment" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105698 name: embryonic skeletogenic mesenchyme def: "The embryonic tissue made up of loosely connected mesoderm cells that will produce all of the skeletal elements." [] synonym: " primary mesenchyme" EXACT [] synonym: "SM" EXACT [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106220 ! embryonic skeletogenic mesoderm relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105700 name: skeletal rod synonym: "spicule rod" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105710 name: anonymous rod is_a: ECAO:0105700 ! skeletal rod relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105720 name: right anonymous rod is_a: ECAO:0105710 ! anonymous rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105730 name: left anonymous rod is_a: ECAO:0105710 ! anonymous rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105738 name: right dorsoventral connecting rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105740 name: right anterolateral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105738 ! right dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105748 name: left dorsoventral connecting rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105750 name: left anterolateral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105748 ! left dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105760 name: right postoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105720 ! right anonymous rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105770 name: left postoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105730 ! left anonymous rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105780 name: right posterodorsal rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105790 name: left posterodorsal rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105798 name: dorsal arch is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105800 name: right preoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105798 ! dorsal arch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105810 name: left preoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105798 ! dorsal arch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105850 name: right ventral transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105860 name: left ventral transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105868 name: posterior tip of body rod is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105870 name: scheitel synonym: "body rod end" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105880 name: body rod is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105890 name: left body rod is_a: ECAO:0105880 ! body rod is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105900 name: right body rod is_a: ECAO:0105880 ! body rod is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105920 name: posterior tip of left body rod is_a: ECAO:0105868 ! posterior tip of body rod relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105930 name: posteror tip of right body rod is_a: ECAO:0105868 ! posterior tip of body rod relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105940 name: right recurrent rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105738 ! right dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105950 name: left recurrent rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105748 ! left dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105960 name: posterior transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105970 name: mouth xref: UBERON:0000165 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105980 name: larval mouth is_a: ECAO:0105970 ! mouth is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105450 ! stomodeum relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105990 name: anus xref: UBERON:0001245 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106000 name: larval anus is_a: ECAO:0105990 ! anus is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103980 ! blastopore relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106010 name: presumptive endoderm synonym: "prospective endoderm" EXACT [] xref: UBERON:0006595 is_a: ECAO:0105158 ! embryonic tissue relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106020 name: endoderm xref: UBERON:0000925 is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106010 ! presumptive endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106030 name: archenteron synonym: " primitive gut" EXACT [] synonym: "embryonic gut" EXACT [] xref: UBERON:0004735 is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106040 name: hindgut xref: UBERON:0001046 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106050 name: dorsal hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106060 name: ventral hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106070 name: midgut xref: UBERON:0001045 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106080 name: ventral midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106090 name: dorsal midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106100 name: anterior midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106110 name: posterior midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106120 name: anterior hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106130 name: posterior hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106140 name: foregut synonym: "tip of the digestive tract" EXACT [] xref: UBERON:0001041 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106150 name: ventral foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106160 name: dorsal foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106170 name: anterior foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106180 name: posterior foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106190 name: tip of archenteron synonym: "archenteron roof" EXACT [] xref: UBERON:3010432 is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106200 name: presumptive mesoderm synonym: "prospective mesoderm" EXACT [] xref: UBERON:0006603 is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106210 name: mesoderm xref: UBERON:0000926 is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106220 name: embryonic skeletogenic mesoderm def: "The subset of the embryonic mesoderm that will later give rise to the skeletogenic mesenchyme and embryonic skeleton." [] is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000590 ! very late blastula stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106240 name: embryonic skeletogenic mesenchyme cell synonym: " primary mesenchyme cell" EXACT [] synonym: "PMC" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0105698 ! embryonic skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106250 name: syncytium synonym: " multinucleated cell" EXACT [] synonym: " syncytial cell" EXACT [] synonym: " syncytium" EXACT [] synonym: "multinucleate cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106260 name: embryonic skeletogenic mesenchyme syncytium def: "Anatomical structure composed of skeletogenic mesenchyme cells that have fused to form a single syncytial network." [] is_a: ECAO:0106250 ! syncytium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106270 name: subequatorial skeletogenic mesenchyme ring synonym: " PMC ring" EXACT [] synonym: " primary mesenchyme cell ring" EXACT [] synonym: " subequatorial PMC ring" EXACT [] synonym: " subequatorial primary mesenchyme cell ring" EXACT [] synonym: " subequatorial SM ring" EXACT [] synonym: "SM ring" EXACT [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106260 ! embryonic skeletogenic mesenchyme syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106280 name: ventral skeletogenic mesenchyme chain def: "Subpopulation of skeletogenic mesenchyme forming a chain on the oral (i.e. ventral) side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106290 name: dorsal skeletogenic mesenchyme chain def: "Subpopulation of skeletogenic mesenchyme forming a chain on the aboral (i.e. dorsal) side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106300 name: right ventrolateral skeletogenic mesenchyme cluster def: "Subpopulation of skeletogenic mesenchyme forming a cluster (i.e. a group of cells) in the ventrolateral region of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106310 name: left ventrolateral skeletogenic mesenchyme cluster is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106320 name: lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain on either side of the developing digestive tract, along the blastocoel wall and towards the animal pole." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106260 ! embryonic skeletogenic mesenchyme syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106330 name: right lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain along the blastocoel wall towards the animal pole on the right side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0106320 ! lateral chain of skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106340 name: left lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain along the blastocoel wall towards the animal pole on the left side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0106320 ! lateral chain of skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106350 name: embryonic non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000590 ! very late blastula stage relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106360 name: ventral non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106370 name: dorsal non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula phase relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106380 name: embryonic non-skeletogenic mesenchyme synonym: " NSM" EXACT [] synonym: "secondary mesenchyme" EXACT [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106390 name: embryonic non-skeletogenic mesenchyme cell synonym: " secondary mesenchyme cell" EXACT [] synonym: "SMC" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106380 ! embryonic non-skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106400 name: larval non-skeletogenic mesenchyme is_a: ECAO:0104110 ! tissue relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106410 name: larval non-skeletogenic mesenchyme cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106400 ! larval non-skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106420 name: presumptive blastocoelar cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106430 name: presumptive pigment cell synonym: " presumptive immunocyte" EXACT [] synonym: "presumptive pigmented cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106440 name: pigment cell def: "a cell that contains red coloring matter" [] synonym: " pigmented immunocyte" EXACT [] synonym: "pigmented cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106430 ! presumptive pigment cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106450 name: embryonic pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0103670 ! embryonic immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106460 name: larval pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106470 name: juvenile pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103690 ! juvenile immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106480 name: rudiment pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106490 name: blastocoelar cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106420 ! presumptive blastocoelar cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106500 name: globular cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106510 name: filopodial cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106520 name: ovoid cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106530 name: amoeboid cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106540 name: muscle precursor cell synonym: "presumptive muscle cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000460 ! early pluteus larva stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106550 name: muscle is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106560 name: larval muscle synonym: "contractile muscle" EXACT [] is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103780 ! larval muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106570 name: rudiment muscle is_a: ECAO:0105410 ! rudiment tissue relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106580 name: juvenile muscle is_a: ECAO:0105420 ! juvenile tissue relationship: part_of ECAO:0103790 ! juvenile muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106590 name: adult muscle is_a: ECAO:0105430 ! adult tissue relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103800 ! adult muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106600 name: blastocoel xref: UBERON:0000090 is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106610 name: sphincter is_a: ECAO:0104050 ! digestive system element relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106620 name: pyloric sphincter synonym: "midgut-hindgut constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106630 name: cardiac sphincter synonym: "foregut-midgut constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106640 name: anal sphincter synonym: "hindgut-ectoderm constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106650 name: sphincter muscle xref: UBERON:0004590 is_a: ECAO:0106550 ! muscle is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106660 name: sphincter muscle cell synonym: "myoepithelial cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0106650 ! sphincter muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106670 name: pyloric sphincteric muscle synonym: "pyloric sphincter" EXACT [] xref: UBERON:0001202 is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106680 name: cardiac sphincteric muscle synonym: "cardiac sphincter" EXACT [] is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106690 name: anal sphincteric muscle synonym: "anal sphincter" EXACT [] xref: UBERON:0004916 is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106700 name: larval esophagus is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106140 ! foregut relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106708 name: circumesophageal muscle is_a: ECAO:0106560 ! larval muscle is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106700 ! larval esophagus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106710 name: circumesophageal muscle cell synonym: "presumptive circumesophageal muscle cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106708 ! circumesophageal muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106730 name: larval stomach is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106070 ! midgut relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106740 name: larval intestine is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106040 ! hindgut relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106750 name: larval skeletogenic mesenchyme def: "The mesenchyme cells that produce new skeletal elements (i.e., the posterodorsal rods, dorsal arch, and preoral rods) in the larva after feeding begins" [] is_a: ECAO:0104110 ! tissue relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106760 name: larval skeletogenic mesenchyme cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0106750 ! larval skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106770 name: coelom xref: UBERON:0011997 is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106780 name: unpaired coelomic pouch synonym: "unpaired coelomic rudiment" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106790 name: right coelomic pouch is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106800 name: left coelomic pouch synonym: "left coelomic sac" EXACT [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106810 name: right coelomic constriction is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0106790 ! right coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106820 name: left coelomic constriction is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106828 name: larval epithelium is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106830 name: vestibule synonym: "amniotic sac" EXACT [] is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105200 ! ventral ectoderm relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106840 name: oral epithelium synonym: " circumoral ectoderm" EXACT [] synonym: " circumoral epithelium" EXACT [] synonym: "oral epidermis" EXACT [] xref: UBERON:0002424 is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106850 name: aboral epithelium is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106858 name: left lateral field def: "The left lateral field is the lateral field located on the left side of the larva" [] is_a: ECAO:0107100 ! lateral field property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106860 name: vestibular pore def: "Opening located in the left lateral field" [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106858 ! left lateral field relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106868 name: axocoel synonym: "anterior coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106870 name: left axocoel is_a: ECAO:0106868 ! axocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106880 name: axial coelom is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106870 ! left axocoel relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106890 name: hydrocoel synonym: "central coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106910 name: somatocoel synonym: "posterior coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106920 name: left hydrocoel is_a: ECAO:0106890 ! hydrocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106930 name: left somatocoel is_a: ECAO:0106910 ! somatocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106940 name: right axohydrocoel synonym: "anterior sac" EXACT [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106790 ! right coelomic pouch relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106950 name: right somatocoel is_a: ECAO:0106910 ! somatocoel relationship: develops_from ECAO:0106790 ! right coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106958 name: axial complex is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106960 name: stone canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106970 name: ring canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106920 ! left hydrocoel relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106980 name: radial canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106920 ! left hydrocoel relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106990 name: primary pore canal synonym: "hydropore canal" EXACT [] is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106380 ! embryonic non-skeletogenic mesenchyme relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107000 name: hydropore is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107010 name: right axocoel is_a: ECAO:0106868 ! axocoel relationship: develops_from ECAO:0106940 ! right axohydrocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107020 name: right hydrocoel is_a: ECAO:0106890 ! hydrocoel relationship: develops_from ECAO:0106940 ! right axohydrocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107040 name: axial sinus is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107020 ! right hydrocoel relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107050 name: axial organ is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107060 name: dorsal sac is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107070 name: ciliated epaulette is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105460 ! ciliary band relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107080 name: anterior ciliated epaulette is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107070 ! ciliated epaulette property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107090 name: posterior ciliated epaulette is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107070 ! ciliated epaulette property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107100 name: lateral field def: "The lateral field is located in the aboral ectoderm of the larva. It separates the anterior and posterior pairs of epaulettes" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107120 name: right lateral field def: "The right lateral field is the lateral field located on the right side of the larva" [] is_a: ECAO:0107100 ! lateral field property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107140 name: ambulacral plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107150 name: adult skeletogenic mesenchyme def: "The mesenchyme cells that produce biomineralized elements (e.g., spines, test plates, and teeth) in the juvenile and adult." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107160 name: interambulacral plate synonym: "int" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107170 name: ambulacra is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107180 name: interambulacra is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107190 name: genital plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107200 name: appendage is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107210 name: pedicellaria xref: UBERON:0008261 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107220 name: ocular plate synonym: "terminal plate" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107230 name: buccal plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107240 name: genital plate AB is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107250 name: genital plate BC is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107260 name: genital plate CD is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107270 name: genital plate DE is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107280 name: genital plate EA is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107290 name: podia synonym: "tube foot" EXACT [] xref: UBERON:0008247 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107300 name: primary podia synonym: "primary tube foot" EXACT [] is_a: ECAO:0107290 ! podia relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107310 name: disk of primary podia is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107300 ! primary podia property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107320 name: secondary podia synonym: "secondary tube foot" EXACT [] is_a: ECAO:0107290 ! podia relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107330 name: disk of secondary podia is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107320 ! secondary podia property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107340 name: buccal podia is_a: ECAO:0104990 ! primary podia associated neuron relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107350 name: spine synonym: "spine appendage" EXACT [] xref: UBERON:0008260 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107360 name: juvenile spine synonym: "splayed spines" EXACT [] is_a: ECAO:0107350 ! spine relationship: existence_ends_during ECAO:0000560 ! late juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107370 name: definitive spine synonym: "adult spine" EXACT [] is_a: ECAO:0107350 ! spine property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107380 name: sphaeridium is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107390 name: ampulla synonym: "tube foot ampulla" EXACT [] xref: UBERON:0008252 is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106980 ! radial canal relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107400 name: adult mouth is_a: ECAO:0105970 ! mouth relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107410 name: adult anus is_a: ECAO:0105990 ! anus relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107418 name: Aristotles lantern xref: UBERON:0008253 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107420 name: tooth is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107418 ! Aristotles lantern property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107440 name: madreporite xref: UBERON:0009476 is_a: ECAO:0107190 ! genital plate is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107260 ! genital plate CD relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107450 name: gonopore synonym: "genital pore" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107460 name: gonad xref: UBERON:0000991 is_a: ECAO:0104100 ! adult structure relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107470 name: ovary xref: UBERON:0000992 is_a: ECAO:0107460 ! gonad property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107480 name: testis xref: UBERON:0000473 is_a: ECAO:0107460 ! gonad property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107490 name: juvenile digestive tract is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103640 ! juvenile digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107510 name: adult digestive tract is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103630 ! larval digestive system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107520 name: mesentery xref: UBERON:0002095 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107530 name: perivisceral cavity is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107540 name: photosensory cell synonym: "photoreceptor cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107560 name: embryonic territory def: "A population of embryonic cells that share a common developmental fate or program of gene expression and comprising a region that lacks clear morphological boundaries" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000610 ! open mouth stage relationship: existence_starts_during ECAO:0000190 ! 16-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107570 name: adult organism def: "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage." [] xref: UBERON:0007023 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103580 ! larva relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107580 name: embryonic muscular system def: "The muscle system of the embryo." [] is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during ECAO:0000610 ! open mouth stage relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107590 name: extracellular matrix def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [] is_a: ECAO:0104270 ! acellular membrane relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107600 name: blastomere of 8-cell embryo def: "A blastomere of an 8-cell embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000180 ! 8-cell stage relationship: existence_starts_during ECAO:0000180 ! 8-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107610 name: blastomere of 16-cell embryo def: "A blastomere of a 16-cell embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000190 ! 16-cell stage relationship: existence_starts_during ECAO:0000190 ! 16-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107620 name: presumptive animal pole domain neuron def: "A cell that will develop into a neuron of the animal pole domain." [] synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107630 name: presumptive ectoderm neuron def: "An ectodermal cell that will develop into a neuron." [] synonym: "ectoderm neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107640 name: presumptive ciliary band neuron def: "A cell that will develop into a neuron of the ciliary band." [] synonym: "ciliary band neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107650 name: presumptive endoderm-associated neuron def: "An endodermal cell that will develop into a neuron." [] synonym: " endoderm-ssociated neuronal progenitor cell" EXACT [] synonym: "presumptive endodermal neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107660 name: postoral neuron def: "A neuron located near the base of an oral arm and outside the ciliary band." [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000620 ! early prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107670 name: presumptive postoral neuron def: "A cell that will give rise to a postoral neuron." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107680 name: synaptotagmin-B-expressing neuron def: "A neuron that produces the synaptotagmin-B protein." [] synonym: " synaptotagmin-positive neuron" EXACT [] synonym: "synaptotagmin- B neuron" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_ends_during ECAO:0000530 ! adulthood phase relationship: existence_starts_during ECAO:0000410 ! late gastrula stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107690 name: nitric oxide synthase-expressing neuron def: "A neuron that produces the nitric oxide synthase protein." [] is_a: ECAO:0104790 ! neuron relationship: existence_ends_during ECAO:0000530 ! adulthood phase relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107700 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [] is_a: ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107710 name: catecholaminergic/cholinergic neuron def: "A neuron that uses both acetylcholine and catecholamines as vesicular neurotransmitters." [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000640 ! early pluteus stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107720 name: endoderm-associated neuron def: "A neuron derived from endoderm." [] synonym: "endodermal neuron" EXACT [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104780 ! endoderm associated presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107730 name: lateral ganglion def: "One of two bilateral ganglia that arise in the oral ectoderm near the ciliary band." [] is_a: ECAO:0104930 ! ganglion is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103970 ! animal pole domain relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107740 name: right lateral ganglion def: "The lateral ganglion that forms on the right side of the embryo." [] is_a: ECAO:0107730 ! lateral ganglion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107750 name: left lateral ganglion def: "The lateral ganglion that forms on the left side of the embryo." [] is_a: ECAO:0107730 ! lateral ganglion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107760 name: presumptive ventral ectoderm def: "The part of the blastula that will give rise to ventral ectoderm." [] synonym: "presumptive oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory relationship: existence_ends_during ECAO:0000400 ! mid-gastrula stage relationship: existence_starts_during ECAO:0000230 ! 60-cell stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107770 name: presumptive dorsal ectoderm def: "The part of the blastula that will give rise to dorsal ectoderm." [] synonym: "presumptive aboral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory relationship: existence_ends_during ECAO:0000400 ! mid-gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107780 name: anterior neuroectoderm def: "A dynamic terriritory within the prospective ectoderm of the early embryo, located at the anterior (animal) end of the embryo and shaped by Wnt signaling, that contains cells with neurogenic potential." [] synonym: " ANE" EXACT [] synonym: "animal ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107790 name: equatorial ectoderm def: "A dynamic territory within the prospective ectoderm of the early embryo, located between the anterior neuroectoderm and the endomesoderm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107800 name: inner anterior neuroectoderm def: "The innermost part of the anterior neuroectoderm, immediately surrounding the animal pole." [] synonym: " inner apical pole domain" EXACT [] synonym: "inner ANE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107810 name: outer anterior neuroectoderm def: "A torus shaped region comprising the outer part of the anterior neuroectoderm." [] synonym: " outer apical pole domain" EXACT [] synonym: "outer ANE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107820 name: central ventral ectoderm def: "A region of the ectoderm derived from the animal hemisphere (i.e., mesomere descendants) and located just above the equator on the ventral side of the embryo." [] synonym: "central oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107830 name: near apical ectoderm def: "A region of the ectoderm derived from the animal hemisphere (i.e., mesomere descendants) and located between the central ventral ectoderm and the animal pole domain on the ventral side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107840 name: lateral border ectoderm def: "A region of border ectoderm located on a lateral surface of the embryo." [] synonym: " lateral BE" EXACT [] synonym: "veg1 lateral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107850 name: ventral border ectoderm def: "A region of border ectoderm located on the ventral side of the embryo." [] synonym: " oral BE" EXACT [] synonym: " oral border ectoderm" EXACT [] synonym: " ventral BE" EXACT [] synonym: "veg1 oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107860 name: dorsal border ectoderm def: "A region of border ectoderm located on the dorsal side of the embryo." [] synonym: " aboral BE" EXACT [] synonym: " aboral border ectoderm" EXACT [] synonym: " dorsal BE" EXACT [] synonym: "veg1 aboral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107870 name: animal lateral ectoderm def: "A region of ectoderm derived from the animal hemisphere and located laterally at the boundary between hte ventral and dorsal ectoderm; this region overlaps with part of the prospective ciliary band." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107880 name: right animal lateral ectoderm def: "The animal lateral ectoderm on the right side of the embryo." [] is_a: ECAO:0105320 ! lateral ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107890 name: left animal lateral ectoderm def: "The animal lateral ectoderm on the left side of the embryo." [] is_a: ECAO:0105320 ! lateral ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula episode relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107900 name: postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107910 name: right postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of the right postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0107900 ! postoral arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107920 name: left postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of the left postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0107900 ! postoral arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107930 name: presumptive ciliary band def: "The cells that will give rise to the ciliary band." [] synonym: "presumptive ciliated band" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107940 name: arm def: "An elongated extension of the embryo on the ventral side, supported by a simple or fenestrated skeletal rod and often covered in part by a ciliary band. Arms develop in bilaterally symmetrical pairs." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107950 name: anterolateral arm def: "A type of arm that projects from the oral hood; forms after the postoral arms appear and prior to the appearance of the preoral and posterodorsal arms." [] is_a: ECAO:0107940 ! arm relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107960 name: postoral arm def: "A type of arm that forms between the equator and the posterior pole, near the position of the skeletal rudiment; the first type of arm to appear." [] is_a: ECAO:0107940 ! arm relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107970 name: anterolateral rod def: "A rod that forms by the branching or pronounced curving of the anterior tip of a dorsoventral connecting rod and that projects ventrally from the oral hood, supporting an anterolateral arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0107990 ! dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107980 name: postoral rod def: "A rod that forms by the branching of the anonymous rod and projects ventrally, supporting a postoral arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105710 ! anonymous rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107990 name: dorsoventral connecting rod def: "A rod that initially forms as one of the three arms of the embryonic triradiate spicule rudiment; this rod extends toward the animal pole before branching or curving to form the anterolateral rod and, in some species, the recurrent rod." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108000 name: ventral transverse rod def: "A rod that initially forms as one of the three arms of the embryonic triradiate spicule rudiment; this rod projects toward the ventral midline and ceases growth early in development without branching." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108010 name: distal tip of body rod def: "The growing tip of the body rod as it extends dorsally." [] is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108020 name: distal tip of right body rod def: "The distal tip of the body rod that forms on the right side of the embryo." [] is_a: ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108030 name: distal tip of left body rod def: "The distal tip of the body rod that forms on the left side of the embryo.." [] is_a: ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108040 name: recurrent rod def: "A rod that forms from the branching of a dorsoventral transverse rod and extends dorsally." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0107990 ! dorsoventral connecting rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108050 name: presumptive embryonic skeletogenic mesoderm def: "The part of the embryonic presumptive mesoderm that will later give rise to the skeletogenic mesenchyme and embryonic skeleton." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000600 ! vegetal plate stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108060 name: ventrolateral skeletogenic mesenchyme cluster def: "A cluster of skeletogenic cell bodies that forms in the ventrolateral region of the subequatorial skeletogenic mesenchyme ring; one triradiate spicule rudiment will form in each of two ventrolateral clusters." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108070 name: presumptive embryonic non-skeletogenic mesoderm def: "Embryonic cells tin the epithelial wall of the vegetal plate or the archenteron that will give rise to mesodermal derivatives other than skeleton." [] synonym: "NSM" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108080 name: ventral presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm on the ventral side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108090 name: dorsal presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm on the dorsal side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108100 name: presumptive muscle cell def: "A cell that will give rise to a muscle cell." [] synonym: "muscle precursor cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108110 name: muscle cell def: "A cell that is part of a muscle." [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0108100 ! presumptive muscle cell relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106550 ! muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108120 name: presumptive blastocoel def: "The inner, extracellular space between blastomeres of the cleavage stage embryo that will gradually expand and form the blastocoel." [] is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108130 name: pyloric sphincter muscle cell def: "A cell that is part of the pyloric sphincter." [] is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000610 ! open mouth stage relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108140 name: cardiac sphincter muscle cell def: "A cell that is part of the cardiac sphincter." [] is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108150 name: anal sphincter muscle cell def: "A cell that is part of the anal sphincter." [] synonym: "anal pore muscle cell" EXACT [] xref: UBERON:0004916 is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108160 name: primary pore canal rudiment def: "A strand of mesenchyme cells that extends from the left coelom to the ectoderm and that will give rise to the primary pore canal." [] synonym: "presumptive hydropore canal" EXACT [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108170 name: posterior enterocoel def: "An evagination of the midgut that will contribute to the coelom." [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106070 ! midgut relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108180 name: left anterior coelomic pouch def: "In species with a posterior enterocoel, the left coelomic pouch that evaginates from the unpaired coelomic pouch at the anterior end of the archenteron." [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108190 name: right anterior coelomic pouch def: "In species with a posterior enterocoel, the right coelomic pouch that evaginates from the unpaired coelomic pouch at the anterior end of the archenteron." [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108200 name: preoral ciliary band def: "In species with two separate ciliary bands, a ciliary band that surrounds the anterior-ventral end of the embryo, anterior to the mouth." [] is_a: ECAO:0105460 ! ciliary band is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107930 ! presumptive ciliary band relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108210 name: postoral ciliary band def: "In species with two separate ciliary bands, a ciliary band that surrounds the posterior-dorsal end of the embryo, posterior to the mouth." [] is_a: ECAO:0105460 ! ciliary band is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107930 ! presumptive ciliary band relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109000 name: anatomical element def: "An anatomical structure that is a subdivision of a tissue, a germ layer, or an organ of the whole organism but with well-defined morphological boundaries." [] synonym: "anatomical object" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109010 name: zygote def: "A diploid cell produced by the fusion of a male and a female gamete at fertilization. It constitutes the first stage of the embryogenesis life cycle phase." [] synonym: " 1-cell" EXACT [] synonym: "fertilized egg" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109020 name: cleavage embryo def: "A multicellular organism at an early stage of development characterized by cleavage. It includes all forms of the cleavage period during the embryogenesis life cycle phase (i.e., from first cleavage to before the formation of the blastula)." [] synonym: "cleaving embryo" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109010 ! zygote relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109030 name: blastula def: "A multicellular organism at an early stage of development corresponding to a hollow, spherical, multicellular, monolayered embryo with a hollow cavity (the blastocoel) in the center. It includes all forms of the blastula period during the embryogenesis life cycle phase." [] synonym: "morula" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109020 ! cleavage embryo relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109040 name: gastrula def: "A multicellular organism at an early stage of development characterized by morphogenetic movements. It includes all forms of the gastrula period during the embryogenesis life cycle phase." [] synonym: "gastrulating embryo" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109030 ! blastula relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109050 name: pre-metamorphic organism def: "A multicellular organism the existence of which starts at fertilization and ends with metamorphosis. It includes all forms during the embryogenesis and larval development life cycle phases." [] synonym: "pre-metamorphosing organism" EXACT [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109010 ! zygote relationship: existence_ends_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109060 name: post-embryonic organism def: "A multicellular organism the existence of which starts upon the opening of the mouth and ends with death. It includes all forms during the larval development and adulthood phase life cycle phases." [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103570 ! embryo relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109070 name: mature adult def: "A multicellular organism the existence of which starts with gamete production and ends with death." [] synonym: " post-juvenile adult" EXACT [] synonym: "sexually mature adult" EXACT [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103590 ! juvenile relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109080 name: embryonic region def: "A portion of an embryo (or a population of embryonic cells) that is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "embryonic territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109090 name: larval region def: "A portion of a larva (or a population of larval cells) that is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "larval territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109100 name: pre-metamorphic organism region def: "A population of cells that, throughout the embryogenesis and larval development life cycle phases, is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "pre-metamorphic territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109110 name: organ def: "A multicellular anatomical structure made of several tissues, performing a specific function or group of functions." [] is_a: ECAO:0109000 ! anatomical element relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103520 ! anatomical system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109120 name: pre-metamorphic organism tissue def: "A tissue that is present in a pre-metamorphic organism." [] is_a: ECAO:0104110 ! tissue relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109130 name: pre-metamorphic organism structure def: "An anatomical structure that is part of a pre-metamorphic organism." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109140 name: pre-metamorphic organism immune system def: "The immune system of a pre-metamorphic organism." [] is_a: ECAO:0103660 ! immune system relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109150 name: female reproductive system def: "An anatomical reproductive system that is present in a female multicellular organism." [] is_a: ECAO:0103710 ! reproductive system relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109160 name: male reproductive system def: "An anatomical reproductive system that is present in a male multicellular organism." [] is_a: ECAO:0103710 ! reproductive system relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109170 name: pre-metamorphic organism nervous system def: "The neurons and glial cells constituting the nervous system of a pre-metamorphic organism." [] is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109180 name: pre-metamorphic organism endoskeleton def: "The endoskeleton of a pre-metamorphic organism." [] synonym: "pre-metamorphic organism skeleton" EXACT [] is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109190 name: skeletal tissue def: "A specialized form of connective tissue in which the extracellular matrix is mineralized and that functions in mechanical and structural support." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109200 name: embryonic hemisphere def: "One of two hemispheres of an embryo." [] synonym: "hemisphere of embryo" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109210 name: animal cell tier def: "A cell tier present in the animal hemisphere of an embryo." [] synonym: "animal blastomere tier" EXACT [] is_a: ECAO:0104678 ! cell tier relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109220 name: vegetal cell tier def: "A cell tier present in the vegetal hemisphere of an embryo." [] synonym: "vegetal blastomere tier" EXACT [] is_a: ECAO:0104678 ! cell tier relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109230 name: cell body def: "The portion of a cell bearing surface projections such as axons, filopodia, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109240 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [] synonym: " germline cell" EXACT [] synonym: "germ line stem cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109250 name: female germ cell def: "A germ cell that supports female gamete production." [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109260 name: male germ cell def: "A germ cell that supports male gamete production." [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109270 name: mature germ cell def: "The reproductive haploid, mature sexual reproductive cell of a multicellular organism." [] synonym: "gamete" EXACT [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109280 name: primary oocyte def: "An immature oocyte that is diploid and has not completed female meiosis I." [] is_a: ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109290 name: secondary oocyte def: "An immature oocyte that is haploid but has not completed female meiosis II." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109280 ! primary oocyte relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109300 name: spermatogonium def: "An euploid male germ cell of an early stage of spermatogenesis. It is morphologically unlike spermatocytes and spermatids." [] is_a: ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109310 name: spermatocyte def: "A male germ cell that develops from spermatogonia." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109300 ! spermatogonium relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109320 name: spermatid def: "A male germ cell that develops from spermatocytes." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109310 ! spermatocyte relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109330 name: spermatozoid nucleus def: "An intracellular anatomical structure in which the male chromosomes are housed." [] synonym: " male germ cell nucleus" EXACT [] synonym: "sperm nucleus" EXACT [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109340 name: oocyte nucleus def: "An intracellular anatomical structure in which the female chromosomes are housed." [] synonym: " female germ cell nucleus" EXACT [] synonym: "female nucleus" EXACT [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109350 name: cellular anatomical entity def: "Any constituent part of a cell that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical structure." [] synonym: "cell part" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109360 name: intracellular anatomical structure def: "A component of a cell contained within (but not including) the plasma membrane. It includes as examples the nucleus, mitochondria, vesicles, and the cytoskeleton." [] synonym: " organelle" EXACT [] synonym: "intracellular part" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109370 name: cell-cell junction def: "A cell junction that forms a connection between two or more cells of a multicellular organism." [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000165 ! stage 3 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109380 name: desmosome def: "A strong cell-cell junction usually found in tissue that experience intense mechanical stress." [] synonym: "spot desmosome" EXACT [] is_a: ECAO:0109370 ! cell-cell junction property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109390 name: septate junction def: "A cell-cell junction that forms a continuous band around each cell in an epithelium." [] synonym: "spetate desmosome" EXACT [] is_a: ECAO:0109370 ! cell-cell junction property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109400 name: adherens junction def: "A cell-cell junction composed of the epithelial cadherin-catenin complex." [] is_a: ECAO:0109370 ! cell-cell junction relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109410 name: microtubule cytoskeleton def: "The part of the cytoskeleton composed of microtubules and associated proteins." [] is_a: ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109420 name: filament def: "A component of a cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [] synonym: " fiber" EXACT [] synonym: " polymeric cytoskeletal fiber" EXACT [] synonym: "protein filament" EXACT [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109430 name: spindle pole def: "The either end of a spindle, from where the spindle microtubules emanate." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0109410 ! microtubule cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109440 name: equator region def: "The middle region of an oocyte or a zygote, which comprises the most basal portion of the animal and vegetal hemispheres." [] synonym: "equator" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109450 name: kinetochore def: "A multisubunit complex that is located on chromosomes and provides an attachment point for the spindle microtubules." [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: part_of ECAO:0109510 ! chromosome property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109460 name: apical cilium def: "A cilium that develops on the apical surface of a cell." [] is_a: ECAO:0104340 ! cilium relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109470 name: short motile cilium def: "A cilium of short size exhibiting motility thanks to the molecular motors it contains. In echinoderms, short motile cilia are encountered on the outer surface of the developing embryo as well as in the developing and developed digestive tract of embryos and larvae." [] is_a: ECAO:0104340 ! cilium relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109480 name: long immotile cilium def: "A cilium of long size that does not contain molecular motors and as such does not exhibit any beating movement. In some echinoderms, long immotile cilia are found, when present, at the animal pole of embryos and constitute the apical tuft." [] synonym: " elongated cilium" EXACT [] synonym: "long non-motile cilium" EXACT [] is_a: ECAO:0104340 ! cilium relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0105380 ! apical tuft property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109490 name: filopodial cable def: "A sheet-like cellular projection that is supported by an ordered network of actin filaments and that is involved in cellular motility and syncytium formation." [] synonym: "lamellipodia" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109500 name: nucleolus def: "A small, dense body present in the nucleus of cells and that is rich in RNA and protein, not bounded by a limiting membrane, and not seen during mitosis." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109510 name: chromosome def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109520 name: animal blastomere def: "An undifferentiated cell part of the animal hemisphere of an embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_starts_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109530 name: vegetal blastomere def: "An undifferentiated cell part of the vegetal hemisphere of an embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_starts_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109540 name: macromere descendant cell def: "A cell derived from a macromere through cell division." [] is_a: ECAO:0104010 ! embryonic cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109550 name: presumptive blastocoel def: "The inner, extracellular space between blastomeres of the cleavage stage embryos that will gradually expand and form the blastocoel." [] is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109560 name: blastocoel roof def: "The most apical region of the blastocoel." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0106600 ! blastocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109570 name: blastocoel wall def: "The region of the blastocoel comprised in the middle region of the embryo, below the blastocoel roof." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0106600 ! blastocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109580 name: ectoderm cell def: "A cell part of the ectoderm germ layer." [] synonym: "ectodermal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109590 name: epidermis def: "An epithelium derived from ectoderm and constituting the outermost protective layer of an embryo, a larva, or an adult." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109600 name: epithelium def: "A tissue that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109610 name: embryonic ectoderm def: "The ectoderm that is specifically present in an embryo" [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109620 name: larval ectoderm def: "The ectoderm that is specifically present in a larva." [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109610 ! embryonic ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109630 name: pre-metamorphic organism ectoderm def: "The ectoderm that is specifically present in an embryo and a larva but not in an adult." [] is_a: ECAO:0104908 ! ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109640 name: vegetal tier 1 ectoderm def: "The ectoderm that specifically derives from cells of the veg1 tier." [] synonym: " veg1 ectoderm" EXACT [] synonym: "veg1 ecto" EXACT [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_starts_during ECAO:0000265 ! stage 9 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109650 name: non-apical ectoderm def: "The ectoderm that is part of the animal ectoderm but located below the apical pole domain ectoderm." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0105180 ! animal ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109660 name: apical pole domain def: "A thickened region at the animal hemisphere, located at the animal pole, and that contains developing neurons and cells with elongated cilia." [] synonym: " animal plate" EXACT [] synonym: " apical plate" EXACT [] synonym: "animal pole domain" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109670 name: apical pole domain ectoderm def: "The ectoderm that is part of the animal ectoderm and is specifically restricted to the apical pole domain." [] synonym: "apical ectoderm" EXACT [] is_a: ECAO:0105180 ! animal ectoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0109660 ! apical pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109680 name: presumptive oral ectoderm def: "The portion of the presumptive ectoderm that is located on the oral side of the embryo (which will later generate the ventral side of the larva)." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109690 name: oral ectoderm def: "The portion of the embryonic ectoderm that is located on the oral side of the embryo and will give rise to ventral ectoderm of the larva." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0109680 ! presumptive oral ectoderm relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109700 name: presumptive aboral ectoderm def: "The portion of the presumptive ectoderm that is located on the aboral side of the embryo (which will later generate the dorsal side of the larva)." [] synonym: "lateral-aboral pre-state ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109710 name: aboral ectoderm def: "The portion of the embryonic ectoderm that is located on the aboral side of the embryo and will give rise to dorsal ectoderm of the larva." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0109700 ! presumptive aboral ectoderm relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109720 name: oral border ectoderm def: "The portion of the border ectoderm that is located on the oral side of the embryo." [] synonym: " equatorial oral ectoderm" EXACT [] synonym: " oral BE" EXACT [] synonym: " ventral BE" EXACT [] synonym: "veg1 oral ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109730 name: aboral border ectoderm def: "The portion of the border ectoderm that is located on the aboral side of the embryo." [] synonym: " aboral BE" EXACT [] synonym: " dorsal BE" EXACT [] synonym: "veg1 aboral ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109740 name: stomodeal presumptive ectoderm def: "The portion of the presumptive oral ectoderm where the stomodeum will form." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0109680 ! presumptive oral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109750 name: stomodeal ectoderm def: "The portion of the oral ectoderm where the stomodeum forms." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0109690 ! oral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109760 name: neuroectoderm def: "The portion of the ectoderm where neurons form." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109770 name: presumptive apical pole domain neuron def: "An ectodermal progenitor cell from the animal pole domain that will develop into a neuron." [] synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0109660 ! apical pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109780 name: presumptive endoderm neuron def: "An endodermal cell that will develop into a neuron." [] synonym: " endoderm-ssociated neuronal progenitor cell" EXACT [] synonym: "presumptive endodermal neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109790 name: presumptive postoral arm neuron def: "A neuronal progenitor cell present in the epidermis of a postoral arm." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0110400 ! postoral arm ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109800 name: presumptive oral hood neuron def: "A neuronal progenitor cell present in the epidermis of the oral hood." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0105520 ! oral hood property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109810 name: postoral arm neuron def: "A neuron that is located in the postoral arm ectoderm outside the ciliary band." [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0109790 ! presumptive postoral arm neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109820 name: oral hood neuron def: "A neuron that is located in the oral hood." [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0109800 ! presumptive oral hood neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105520 ! oral hood property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109830 name: nitric oxide synthase neuron def: "A neuron of which transmission is mediated by nitric oxide." [] synonym: "nitrergic neuron" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109840 name: axon def: "The long process of a neuron that conducts nerve impulses, usually away from the neural cell body." [] synonym: "nerve fiber" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109850 name: neural cell body def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons." [] synonym: "neuonal cell body" EXACT [] is_a: ECAO:0109230 ! cell body relationship: part_of ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109860 name: apical organ def: "A neural structure that develops from the apical pole domain, above the mouth, and contains neurons." [] is_a: ECAO:0104878 ! neural structure relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109870 name: presumptive oral hood ciliary band def: "A specific embryonic or larval ectodermal territory located on the oral side and that will give rise to the oral hood ciliary band." [] synonym: "pre-oral ciliary band" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109880 name: ciliary band cell def: "A cell that composes the ciliary band." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109890 name: oral hood ciliary band cell def: "A cell that composes the oral hood ciliary band." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105470 ! oral hood ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109900 name: arm bud ciliary band def: "The portion of the ciliary band that covers the arm buds." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109910 name: arm distal tip ciliary band def: "The portion of the arm ciliary band that covers the arm distal tip." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109920 name: arm proximal tip ciliary band def: "The portion of the arm ciliary band that covers the arm proximal tip." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109930 name: arm middle portion ciliary band def: "The portion of the arm ciliary band that covers the region of the arm between the distal and proximal tips." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109940 name: animal presumptive ciliary band def: "The portion of the presumptive ciliary band that overlaps with the animal pole domain." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109950 name: vegetal presumtive ciliary band def: "The portion of the presumptive ciliary band located close to the vegetal pole." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109960 name: lateral presumptive ciliary band def: "The portion of the presumptive ciliary located between the animal and the vegetal presumptive ciliary bands." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109970 name: preoral presumptive ciliary band def: "In species with two separate ciliary bands, a specific embryonic territory that will develop into the preoral ciliary band." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109980 name: postoral presumptive ciliary band def: "In species with two separate ciliary bands, a specific embryonic territory that will develop into the postoral ciliary band." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109990 name: pre-oral hood def: "A specific ectodermal territory located on the oral side of the embryo or the larva and that will give rise to the oral hood." [] synonym: " preoral lobe" EXACT [] synonym: "preoral hood" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110000 name: arm bud def: "An embryonic region that will develop into an arm." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110010 name: arm distal tip def: "The distal extremity of a larval arm, i.e. the further away from the larval body" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110020 name: arm proximal tip def: "The proximal extremity of a larval arm, i.e. the closest to the larval body" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110030 name: arm middle portion def: "The portion of a larval arm comprised between the distal and proximal tips of the arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110040 name: arm bud ectoderm def: "The thickened ectodermal region that outlines the arm bud." [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110000 ! arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110050 name: arm ectoderm def: "The ectodermal (or epidermal) portion of the arm skin and that does not include the ciliary band." [] synonym: "arm epidermis" EXACT [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0110040 ! arm bud ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110060 name: arm distal tip ectoderm def: "The ectodermal (or epidermal) that covers the distal arm tip and does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110010 ! arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110070 name: arm proximal tip ectoderm def: "The ectodermal (or epidermal) that covers the proximal arm tip and does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110020 ! arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110080 name: arm middle portion ectoderm def: "The ectodermal (or epidermal) that covers the portion of the arm located between the distal and proximal tips and that does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110030 ! arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110090 name: arm bud skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell present in the arm bud and that will contribute to the development of a skeletal rod." [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110000 ! arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110100 name: skeletal rod distal tip def: "The distal tip of a skeletal rod, i.e. the further away from its initiation site." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110110 name: skeletal rod proximal tip def: "The proximal tip of a skeletal rod, i.e. the closest to its initiation site." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110120 name: skeletal rod middle portion def: "The portion of a skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110130 name: arm skeletal rod def: "A skeletal rod supporting an arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105700 ! skeletal rod relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110140 name: arm skeletal rod distal tip def: "The distal tip of an arm skeletal rod, i.e. the further away from its initiation site and the larval body." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110150 name: arm skeletal rod proximal tip def: "The proximal tip of an arm skeletal rod, i.e. the closest to its initiation site and the larval body." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110160 name: arm skeletal rod middle portion def: "The portion of an arm skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110170 name: skeletal rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a skeletal rod." [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110180 name: skeletal rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a skeletal rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110100 ! skeletal rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110190 name: skeletal rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a skeletal rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110110 ! skeletal rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110200 name: skeletal rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the region of a skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110120 ! skeletal rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110210 name: arm skeletal rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an arm skeletal rod." [] synonym: "arm skeletogenic mesenchyme cell" EXACT [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110220 name: arm skeletal rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an arm skeletal rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110140 ! arm skeletal rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110230 name: arm skeletal rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an arm skeletal rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110150 ! arm skeletal rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110240 name: arm skeletal rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the region of an arm skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110160 ! arm skeletal rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110250 name: postoral arm bud def: "An arm bud that will develop into a postoral arm." [] is_a: ECAO:0110000 ! arm bud is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110260 name: right postoral arm bud def: "The arm bud on the right side of the embryo that will develop into a postoral arm." [] is_a: ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110270 name: left postoral arm bud def: "The arm bud on the left side of the embryo that will develop into a postoral arm." [] is_a: ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110280 name: postoral arm distal tip def: "The distal tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110290 name: right postoral arm distal tip def: "The distal tip of a right postoral arm." [] is_a: ECAO:0110280 ! postoral arm distal tip relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110300 name: left postoral arm distal tip def: "The distal tip of a left postoral arm." [] is_a: ECAO:0110280 ! postoral arm distal tip relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110310 name: postoral arm proximal tip def: "The proximal tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110320 name: right postoral arm proximal tip def: "The proximal tip of a right postoral arm." [] is_a: ECAO:0110310 ! postoral arm proximal tip relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110330 name: left postoral arm proximal tip def: "The proximal tip of a left postoral arm." [] is_a: ECAO:0110310 ! postoral arm proximal tip relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110340 name: postoral arm middle portion def: "The middle region of a postoral arm comprised between the distal and proximal tip of the arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110350 name: right postoral arm middle portion def: "The middle region of a right postoral arm." [] is_a: ECAO:0110340 ! postoral arm middle portion relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110360 name: left postoral arm middle portion def: "The middle region of a left postoral arm." [] is_a: ECAO:0110340 ! postoral arm middle portion relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110370 name: postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud." [] is_a: ECAO:0110040 ! arm bud ectoderm relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110380 name: right postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud on the right side of the embryo." [] is_a: ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0110260 ! right postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110390 name: left postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud on the left side of the embryo." [] is_a: ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0110270 ! left postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110400 name: postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a postoral arm but does not include the ciliary band." [] synonym: "postoral ectoderm" EXACT [] is_a: ECAO:0110050 ! arm ectoderm relationship: develops_from ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110410 name: right postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a right postoral arm but does not include the ciliary band." [] synonym: "right postoral ectoderm" EXACT [] is_a: ECAO:0110400 ! postoral arm ectoderm relationship: develops_from ECAO:0110380 ! right postoral arm bud ectoderm relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110420 name: left postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a left postoral arm but does not include the ciliary band." [] synonym: "left postoral ectoderm" EXACT [] is_a: ECAO:0110400 ! postoral arm ectoderm relationship: develops_from ECAO:0110390 ! left postoral arm bud ectoderm relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110430 name: postoral arm distal tip ectoderm def: "The portion of a postoral arm ectoderm located at the distal tip of the arm." [] is_a: ECAO:0110060 ! arm distal tip ectoderm relationship: part_of ECAO:0110280 ! postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110440 name: right postoral arm distal tip ectoderm def: "The postoral arm distal tip ectoderm part of a right postoral arm." [] is_a: ECAO:0110430 ! postoral arm distal tip ectoderm relationship: part_of ECAO:0110290 ! right postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110450 name: left postoral arm distal tip ectoderm def: "The postoral arm distal tip ectoderm part of a left postoral arm." [] is_a: ECAO:0110430 ! postoral arm distal tip ectoderm relationship: part_of ECAO:0110300 ! left postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110460 name: postoral arm proximal tip ectoderm def: "The portion of a postoral arm ectoderm located at the proximal tip of the arm." [] is_a: ECAO:0110070 ! arm proximal tip ectoderm relationship: part_of ECAO:0110310 ! postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110470 name: right postoral arm proximal tip ectoderm def: "The postoral arm proximal tip ectoderm part of a right postoral arm." [] is_a: ECAO:0110460 ! postoral arm proximal tip ectoderm relationship: part_of ECAO:0110320 ! right postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110480 name: left postoral arm proximal tip ectoderm def: "The postoral arm proximal tip ectoderm part of a left postoral arm." [] is_a: ECAO:0110460 ! postoral arm proximal tip ectoderm relationship: part_of ECAO:0110330 ! left postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110490 name: postoral arm middle portion ectoderm def: "The portion of a postoral arm ectoderm located between the distal and proximal tips of the arm." [] is_a: ECAO:0110080 ! arm middle portion ectoderm relationship: part_of ECAO:0110340 ! postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110500 name: right postoral arm middle portion ectoderm def: "The postoral arm middle portion ectoderm part of a right postoral arm." [] is_a: ECAO:0110490 ! postoral arm middle portion ectoderm relationship: part_of ECAO:0110350 ! right postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110510 name: left postoral arm middle portion ectoderm def: "The postoral arm middle portion ectoderm part of a left postoral arm." [] is_a: ECAO:0110490 ! postoral arm middle portion ectoderm relationship: part_of ECAO:0110360 ! left postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110520 name: postoral rod distal tip def: "The distal tip of a postoral rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110530 name: right postoral rod distal tip def: "The distal tip of a right postoral rod." [] is_a: ECAO:0110520 ! postoral rod distal tip relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110540 name: left postoral rod distal tip def: "The distal tip of a left postoral rod." [] is_a: ECAO:0110520 ! postoral rod distal tip relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110550 name: postoral rod proximal tip def: "The proximal tip of a postoral rod." [] is_a: ECAO:0110150 ! arm skeletal rod proximal tip relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110560 name: right postoral rod proximal tip def: "The proximal tip of a right postoral rod." [] is_a: ECAO:0110550 ! postoral rod proximal tip relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110570 name: left postoral rod proximal tip def: "The proximal tip of a left postoral rod." [] is_a: ECAO:0110550 ! postoral rod proximal tip relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110580 name: postoral rod middle portion def: "The middle region of a postoral rod comprised between the distal and proximal tip of the rod." [] is_a: ECAO:0110160 ! arm skeletal rod middle portion relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110590 name: right postoral rod middle portion def: "The middle region of a right postoral rod." [] is_a: ECAO:0110580 ! postoral rod middle portion relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110600 name: left postoral rod middle portion def: "The middle region of a left postoral rod." [] is_a: ECAO:0110580 ! postoral rod middle portion relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110610 name: postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a postoral rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110620 name: right postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right postoral rod." [] is_a: ECAO:0110610 ! postoral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110630 name: left postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left postoral rod." [] is_a: ECAO:0110610 ! postoral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110640 name: postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a postoral rod." [] is_a: ECAO:0110220 ! arm skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110520 ! postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110650 name: right postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right postoral rod." [] is_a: ECAO:0110640 ! postoral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110530 ! right postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110660 name: left postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left postoral rod." [] is_a: ECAO:0110640 ! postoral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110540 ! left postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110670 name: postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a postoral rod." [] is_a: ECAO:0110230 ! arm skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110550 ! postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110680 name: right postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right postoral rod." [] is_a: ECAO:0110670 ! postoral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110560 ! right postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110690 name: left postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left postoral rod." [] is_a: ECAO:0110670 ! postoral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110570 ! left postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110700 name: postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a postoral rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110240 ! arm skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110580 ! postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110710 name: right postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right postoral rod." [] is_a: ECAO:0110700 ! postoral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110590 ! right postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110720 name: left postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left postoral rod." [] is_a: ECAO:0110700 ! postoral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110600 ! left postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110730 name: anonymous rod distal tip def: "The distal tip of an anonymous rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110740 name: right anonymous rod distal tip def: "The distal tip of a right anonymous rod." [] is_a: ECAO:0110730 ! anonymous rod distal tip relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110750 name: left anonymous rod distal tip def: "The distal tip of a left anonymous rod." [] is_a: ECAO:0110730 ! anonymous rod distal tip relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110760 name: anonymous rod proximal tip def: "The proximal tip of an anonymous rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110770 name: right anonymous rod proximal tip def: "The proximal tip of a right anonymous rod." [] is_a: ECAO:0110760 ! anonymous rod proximal tip relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110780 name: left anonymous rod proximal tip def: "The proximal tip of a left anonymous rod." [] is_a: ECAO:0110760 ! anonymous rod proximal tip relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110790 name: anonymous rod middle portion def: "The middle region of an anonymous rod comprised between the distal and proximal tip of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110800 name: right anonymous rod middle portion def: "The middle region of a right anonymous rod." [] is_a: ECAO:0110790 ! anonymous rod middle portion relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110810 name: left anonymous rod middle portion def: "The middle region of a left anonymous rod." [] is_a: ECAO:0110790 ! anonymous rod middle portion relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110820 name: anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110830 name: right anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right anonymous rod." [] is_a: ECAO:0110820 ! anonymous rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110840 name: left anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left anonymous rod." [] is_a: ECAO:0110820 ! anonymous rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110850 name: anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0110730 ! anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110860 name: right anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right anonymous rod." [] is_a: ECAO:0110850 ! anonymous rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110740 ! right anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110870 name: left anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left anonymous rod." [] is_a: ECAO:0110850 ! anonymous rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110750 ! left anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110880 name: anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0110760 ! anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110890 name: right anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right anonymous rod." [] is_a: ECAO:0110880 ! anonymous rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110770 ! right anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110900 name: left anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left anonymous rod." [] is_a: ECAO:0110880 ! anonymous rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110780 ! left anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110910 name: anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of an anonymous rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0110790 ! anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110920 name: right anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right anonymous rod." [] is_a: ECAO:0110910 ! anonymous rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110800 ! right anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110930 name: left anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left anonymous rod." [] is_a: ECAO:0110910 ! anonymous rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110810 ! left anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110940 name: anterolateral rod distal tip def: "The distal tip of an anterolateral rod, i.e. away from its connection with the dorsoventral connecting rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110950 name: right anterolateral rod distal tip def: "The distal tip of a right anterolateral rod." [] is_a: ECAO:0110940 ! anterolateral rod distal tip relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110960 name: left anterolateral rod distal tip def: "The distal tip of a left anterolateral rod." [] is_a: ECAO:0110940 ! anterolateral rod distal tip relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110970 name: anterolateral rod proximal tip def: "The proximal tip of an anterolateral rod, i.e. in connection with the dorsoventral connecting rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110980 name: right anterolateral rod proximal tip def: "The proximal tip of a right anterolateral rod." [] is_a: ECAO:0110970 ! anterolateral rod proximal tip relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110990 name: left anterolateral rod proximal tip def: "The proximal tip of a left anterolateral rod." [] is_a: ECAO:0110970 ! anterolateral rod proximal tip relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111000 name: anterolateral rod middle portion def: "The middle portion of an anterolateral rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111010 name: right anterolateral rod middle portion def: "The middle portion of a right anterolateral rod." [] is_a: ECAO:0111000 ! anterolateral rod middle portion relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111020 name: left anterolateral rod middle portion def: "The middle portion of a left anterolateral rod." [] is_a: ECAO:0111000 ! anterolateral rod middle portion relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111030 name: anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an anterolateral rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111040 name: right anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right anterolateral rod." [] is_a: ECAO:0111030 ! anterolateral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111050 name: left anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left anterolateral rod." [] is_a: ECAO:0111030 ! anterolateral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111060 name: anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an anterolateral rod." [] is_a: ECAO:0110220 ! arm skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110940 ! anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111070 name: right anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right anterolateral rod." [] is_a: ECAO:0111060 ! anterolateral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110950 ! right anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111080 name: left anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left anterolateral rod." [] is_a: ECAO:0111060 ! anterolateral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110960 ! left anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111090 name: anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an anterolateral rod." [] is_a: ECAO:0110230 ! arm skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110970 ! anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111100 name: right anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right anterolateral rod." [] is_a: ECAO:0111090 ! anterolateral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110980 ! right anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111110 name: left anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left anterolateral rod." [] is_a: ECAO:0111090 ! anterolateral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110990 ! left anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111120 name: anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of an anterolateral rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110240 ! arm skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111000 ! anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111130 name: right anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right anterolateral rod." [] is_a: ECAO:0111120 ! anterolateral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111010 ! right anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111140 name: left anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left anterolateral rod." [] is_a: ECAO:0111120 ! anterolateral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111020 ! left anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111150 name: dorsoventral connecting rod animal tip def: "The portion of a dorsoventral connecting rod that bends (or branches) to give rise to the anterolateral rod and in some echinoid species to the recurrent rod." [] synonym: " anterior tip of dorsoventral connecting rod" EXACT [] synonym: "anterior end of dorsoventral connecting rod" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111160 name: right dorsoventral connecting rod animal tip def: "The animal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111150 ! dorsoventral connecting rod animal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111170 name: left dorsoventral connecting rod animal tip def: "The animal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111150 ! dorsoventral connecting rod animal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111180 name: dorsoventral connecting rod distal tip def: "The distal tip of a dorsoventral connecting rod, i.e. in connection with the anterolateral rod and in some echinoid species the recurrent rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111190 name: right dorsoventral connecting rod distal tip def: "The distal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111200 name: left dorsoventral connecting rod distal tip def: "The distal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111210 name: dorsoventral connecting rod proximal tip def: "The proximal tip of a dorsoventral connecting rod, i.e. in connection with the anonymous and ventral transverse rods." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111220 name: right dorsoventral connecting rod proximal tip def: "The proximal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111230 name: left dorsoventral connecting rod proximal tip def: "The proximal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111240 name: dorsoventral connecting rod middle portion def: "The middle portion of a dorsoventral connecting rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111250 name: right dorsoventral connecting rod middle portion def: "The middle portion of a right dorsoventral connecting rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111260 name: left dorsoventral connecting rod middle portion def: "The middle portion of a left dorsoventral connecting rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111270 name: dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a dorsoventral connecting rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111280 name: right dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right dorsoventral connecting rod." [] is_a: ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111290 name: left dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left dorsoventral connecting rod." [] is_a: ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111300 name: dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the bended portion of a dorsoventral connecting rod, before this portion elongates and becomes an anterolateral rod or in some echinoid species branches into a anterolateral and a recurrent rods." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111310 name: right dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the animal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111300 ! dorsoventral connecting rod animal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111280 ! right dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111320 name: left dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the animal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111300 ! dorsoventral connecting rod animal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111290 ! left dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111330 name: dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a dorsoventral connecting rod, before its bended portion." [] is_a: ECAO:0110180 ! skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111180 ! dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111340 name: right dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111330 ! dorsoventral connecting rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111190 ! right dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111350 name: left dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111330 ! dorsoventral connecting rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111200 ! left dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111360 name: dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a dorsoventral connecting rod, in the vicinity of an anonymous and ventral transverse rod." [] is_a: ECAO:0110190 ! skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111210 ! dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111370 name: right dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111360 ! dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111220 ! right dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111380 name: left dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111360 ! dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111230 ! left dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111390 name: dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a dorsoventral connecting rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111240 ! dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111400 name: right dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right dorsoventral connecting rod." [] is_a: ECAO:0111390 ! dorsoventral connecting rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111250 ! right dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111410 name: left dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left dorsoventral connecting rod." [] is_a: ECAO:0111390 ! dorsoventral connecting rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111260 ! left dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111420 name: ventral transverse rod distal tip def: "The distal tip of a ventral transverse rod, i.e. away from the connection with the dorsoventral connecting and anonymous rods." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111430 name: right ventral transverse rod distal tip def: "The distal tip of a right ventral transverse rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111440 name: left ventral transverse rod distal tip def: "The distal tip of a left ventral transverse rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111450 name: ventral transverse rod proximal tip def: "The proximal tip of a ventral transverse rod, i.e. in connection with the dorsoventral connecting and anonymous rods." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111460 name: right ventral transverse rod proximal tip def: "The proximal tip of a right ventral transverse rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111470 name: left ventral transverse rod proximal tip def: "The proximal tip of a left ventral transverse rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111480 name: ventral transverse rod middle portion def: "The middle portion of a ventral transverse rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111490 name: right ventral transverse rod middle portion def: "The middle portion of a right ventral transverse rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111500 name: left ventral transverse rod middle portion def: "The middle portion of a left ventral transverse rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111510 name: ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111520 name: right ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right ventral transverse rod." [] is_a: ECAO:0111510 ! ventral transverse rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111530 name: left ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left ventral transverse rod." [] is_a: ECAO:0111510 ! ventral transverse rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111540 name: ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111420 ! ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111550 name: right ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right ventral transverse rod." [] is_a: ECAO:0111540 ! ventral transverse rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111430 ! right ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111560 name: left ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left ventral transverse rod." [] is_a: ECAO:0111540 ! ventral transverse rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111440 ! left ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111570 name: ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111450 ! ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111580 name: right ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right ventral transverse rod." [] is_a: ECAO:0111570 ! ventral transverse rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111460 ! right ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111590 name: left ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left ventral transverse rod." [] is_a: ECAO:0111570 ! ventral transverse rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111470 ! left ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111600 name: ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a ventral transverse rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0111480 ! ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111610 name: right ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right ventral transverse rod." [] is_a: ECAO:0111600 ! ventral transverse rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111490 ! right ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111620 name: left ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left ventral transverse rod." [] is_a: ECAO:0111600 ! ventral transverse rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111500 ! left ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111630 name: body rod distal tip def: "The growing tip of a body rod as it extends dorsally away from an anonymous rod." [] synonym: " body rod distal tip" EXACT [] synonym: "posterior tip body rod" EXACT [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111640 name: right body rod distal tip def: "The distal tip of a right body rod." [] synonym: "right body rod distal tip" EXACT [] is_a: ECAO:0111630 ! body rod distal tip relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111650 name: left body rod distal tip def: "The distal tip of a left body rod." [] synonym: "left body rod distal tip" EXACT [] is_a: ECAO:0111630 ! body rod distal tip relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111660 name: body rod proximal tip def: "The proximal tip of a body rod, i.e. in connection with an anonymous rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111670 name: right body rod proximal tip def: "The proximal tip of a right body rod." [] is_a: ECAO:0111660 ! body rod proximal tip relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111680 name: left body rod proximal tip def: "The proximal tip of a left body rod." [] is_a: ECAO:0111660 ! body rod proximal tip relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111690 name: body rod middle portion def: "The middle portion of a body rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111700 name: right body rod middle portion def: "The middle portion of a right body rod." [] is_a: ECAO:0111690 ! body rod middle portion relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111710 name: left body rod middle portion def: "The middle portion of a left body rod." [] is_a: ECAO:0111690 ! body rod middle portion relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111720 name: body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111730 name: right body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right body rod." [] is_a: ECAO:0111720 ! body rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111740 name: left body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left body rod." [] is_a: ECAO:0111720 ! body rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111750 name: body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111630 ! body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111760 name: right body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right body rod." [] is_a: ECAO:0111750 ! body rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111640 ! right body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111770 name: left body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left body rod." [] is_a: ECAO:0111750 ! body rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111650 ! left body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111780 name: body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111660 ! body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111790 name: right body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right body rod." [] is_a: ECAO:0111780 ! body rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111670 ! right body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111800 name: left body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left body rod." [] is_a: ECAO:0111780 ! body rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111680 ! left body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111810 name: body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a body rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111690 ! body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111820 name: right body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right body rod." [] is_a: ECAO:0111810 ! body rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111700 ! right body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111830 name: left body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left body rod." [] is_a: ECAO:0111810 ! body rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111710 ! left body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111840 name: scheitel skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a scheitel." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105870 ! scheitel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111850 name: recurrent rod distal tip def: "The distal tip of a recurrent rod, i.e. in connection with a dorsoventral connecting rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111860 name: right recurrent rod distal tip def: "The distal tip of a right recurrent rod." [] is_a: ECAO:0111850 ! recurrent rod distal tip relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111870 name: left recurrent rod distal tip def: "The distal tip of a left recurrent rod." [] is_a: ECAO:0111850 ! recurrent rod distal tip relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111880 name: recurrent rod proximal tip def: "The proximal tip of a recurrent rod, i.e. away from a dorsoventral connecting rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111890 name: right recurrent rod proximal tip def: "The proximal tip of a right recurrent rod." [] is_a: ECAO:0111880 ! recurrent rod proximal tip relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111900 name: left recurrent rod proximal tip def: "The proximal tip of a left recurrent rod." [] is_a: ECAO:0111880 ! recurrent rod proximal tip relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111910 name: recurrent rod middle portion def: "The middle portion of a recurrent rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111920 name: right recurrent rod middle portion def: "The middle portion of a right recurrent rod." [] is_a: ECAO:0111910 ! recurrent rod middle portion relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111930 name: left recurrent rod middle portion def: "The middle portion of a left recurrent rod." [] is_a: ECAO:0111910 ! recurrent rod middle portion relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111940 name: recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111950 name: right recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right recurrent rod." [] is_a: ECAO:0111940 ! recurrent rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111960 name: left recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left recurrent rod." [] is_a: ECAO:0111940 ! recurrent rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111970 name: recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111850 ! recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111980 name: right recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right recurrent rod." [] is_a: ECAO:0111970 ! recurrent rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111860 ! right recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111990 name: left recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left recurrent rod." [] is_a: ECAO:0111970 ! recurrent rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111870 ! left recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112000 name: recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111880 ! recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112010 name: right recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right recurrent rod." [] is_a: ECAO:0112000 ! recurrent rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111890 ! right recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112020 name: left recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left recurrent rod." [] is_a: ECAO:0112000 ! recurrent rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111900 ! left recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112030 name: recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a recurrent rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111910 ! recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112040 name: right recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right recurrent rod." [] is_a: ECAO:0112030 ! recurrent rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111920 ! right recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112050 name: left recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left recurrent rod." [] is_a: ECAO:0112030 ! recurrent rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111930 ! left recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112060 name: enoderm cell def: "A cell part of the endoderm germ layer." [] synonym: "endodermal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112070 name: vegetal tier 1 endoderm def: "The presumptive endoderm that develops specifically from the cells of the vegetal tier 1." [] synonym: " veg1 endoderm" EXACT [] synonym: "veg1 endo" EXACT [] is_a: ECAO:0106010 ! presumptive endoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112080 name: vegetal tier 2 endoderm def: "The presumptive endoderm that develops specifically from the cells of the vegetal tier 2." [] synonym: " veg2 endoderm" EXACT [] synonym: "veg2 endo" EXACT [] is_a: ECAO:0106010 ! presumptive endoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105230 ! endomesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112090 name: embryonic endoderm def: "The endoderm that is specifically present in an embryo." [] is_a: ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112100 name: larval endoderm def: "The endoderm that is specifically present in a larva." [] is_a: ECAO:0106020 ! endoderm relationship: develops_from ECAO:0112090 ! embryonic endoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112110 name: pre-metamorphic organism endoderm def: "The endoderm that is specifically present in an embryo post-gastrulation and a larva but not in an adult." [] is_a: ECAO:0106020 ! endoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112120 name: archenteron tip def: "The anterior territory of the archenteron." [] synonym: " anterior archenteron" EXACT [] synonym: " tip of archetron" EXACT [] synonym: "archenteron roof" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112130 name: archenteron wall def: "The layer of cells that form the archenteron, but at the level of its anterior tip and that of the blastopore." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112140 name: middle hindgut def: "The middle portion of the hindgut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112150 name: middle midgut def: "The middle portion of the midgut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112160 name: middle foregut def: "The middle portion of the foregut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112170 name: esophagus def: "The anterior end of the animal digestive tract that connects the mouth to the stomach." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112180 name: stomach def: "The central region of the animal digestive tract that serves as a digestive organ." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112190 name: intestine def: "The posterior region of the animal digestive tract that extends from the stomach to the anus." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112200 name: coelomic evagination def: "The outpocketing of the mesoderm constituting the tip of the archenteron and forming a bilobed bag (or pouch) lying on the top of the archenteron roof." [] synonym: " unpaire evagination of the coelom" EXACT [] synonym: " unpaired coelomic evaginations" EXACT [] synonym: " unpaired coelomic outpocketing" EXACT [] synonym: " unpaired coelomic rudiment" EXACT [] synonym: "unpaired coelomic pouch" EXACT [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112120 ! archenteron tip relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112210 name: coelomic pouch def: "A mesodermally lined pouch (or pocket) lying between the anterior tip of the archenteron and the outer body wall." [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0112120 ! archenteron tip relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112220 name: constriction def: "A narrowing (or shrinking) within a tissue or organ to delineate different regions with different fates." [] is_a: ECAO:0109000 ! anatomical element relationship: existence_starts_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112230 name: coelomic constriction def: "A constriction taking place at the level of a coelom. It can either separate the coelom from the archenteron or lead to the compartmentalization of the coelom into distinct regions." [] synonym: "coelom constriction" EXACT [] is_a: ECAO:0112220 ! constriction relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0106770 ! coelom property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112240 name: anterior coelomic pouch def: "In species with a posterior enterocoel, the anterior coelomic pouch is the one that develops from the unpaired coelomic evaginations at the tip of the archenteron." [] is_a: ECAO:0112210 ! coelomic pouch relationship: develops_from ECAO:0112200 ! coelomic evagination relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112250 name: larval epidermis def: "An epidermal tissue present in the larva." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112260 name: ventral epiderms def: "The epidermal tissue of the larva that surrounds the mouth." [] synonym: " circumoral ectoderm" EXACT [] synonym: " circumoral epithelium" EXACT [] synonym: "oral epidermis" EXACT [] is_a: ECAO:0106828 ! larval epithelium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105200 ! ventral ectoderm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112270 name: dorsal epidermis def: "The epidermal tissue of the larva that is on the side opposite to the mouth." [] synonym: "aboral epidermis" EXACT [] is_a: ECAO:0106828 ! larval epithelium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105210 ! dorsal ectoderm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112280 name: mesenchyme def: "A tissue composed of mesenchymal cells." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112290 name: mesenchyme cell def: "A cell that has undergone epithelial to mesenchymal transition and is capable of migration." [] synonym: " migratory cell" EXACT [] synonym: " motile cell" EXACT [] synonym: "mesenchymal cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112300 name: presumptive skeletogenic mesoderm def: "The region of the early embryo that will develop into skeletogenic mesoderm." [] is_a: ECAO:0106200 ! presumptive mesoderm relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_ends_during ECAO:0000395 ! stage 14 relationship: existence_starts_during ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112310 name: skeletogenic mesoderm def: "The subset of the mesoderm germ layer that will exclusively give rise to the endoskeleton." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112300 ! presumptive skeletogenic mesoderm relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112320 name: skeletogenic mesoderm cell def: "A cell that has the potential of developing into a skeletogenic mesenchyme cell (or skeletal cell)." [] synonym: "skeletogenic cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112310 ! skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112330 name: skeletogenic mesenchyme def: "The portion of the mesenchyme tissue that constitutes the endoskeleton." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112310 ! skeletogenic mesoderm relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112340 name: skeletogenic mesenchyme cell def: "A cell that after having undergone epithelial to mesenchymal transition participates in constituting the endoskeleton." [] synonym: "skeletal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112330 ! skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112350 name: syncytial filipodial cable def: "A filopodial cable that participates in the establishment of a syncytium." [] synonym: " syncytial cable" EXACT [] synonym: "syncytial lamellipodia" EXACT [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106250 ! syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112360 name: chain of skeletogenic mesenchyme cell def: "A straight, syncitial network that either links the two ventrolateral skeletogenic mesenchyme clusters within the subequatorial skeletogenic mesenchyme ring or extends from the ventrolateral skeletogenic mesenchyme clusters towards the animal pole domain." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112370 name: oral chain of skeletogenic mesenchyme cell def: "The chain of skeletogenic mesenchyme cell that within the subequatorial skeletogenic mesenchyme ring links the two ventrolateral skeletogenic mesenchyme clusters on the oral side of the embryo. The ventral transverse rods will be deposited along this cellular strand." [] synonym: " oral chain of PMCs" EXACT [] synonym: " ventral skeletogenic mesenchyme chain" EXACT [] synonym: "ventral chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112380 name: aboral chain of skeletogenic mesenchyme cell def: "The chain of skeletogenic mesenchyme cell that within the subequatorial skeletogenic mesenchyme ring links the two ventrolateral skeletogenic mesenchyme clusters on the aboral side of the embryo. The body rods will be deposited along this cellular strand." [] synonym: " aboral chain of PMCs" EXACT [] synonym: " dorsal skeletogenic mesenchyme chain" EXACT [] synonym: "dorsal chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112390 name: skeletogenic mesenchyme cluster def: "A cluster of skeletogenic mesenchyme cells that aggregates before any calcification event whether in the embryo, the larva, or the adult." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112400 name: lateral chain of skeletogenic mesenchyme cell def: "A chain of skeletogenic mesenchyme cell that extends from a ventrolateral cluster toward the animal pole. A dorsoventral connecting rod will be deposited along this cellular strand." [] synonym: "lateral chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell relationship: develops_from ECAO:0106240 ! embryonic skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112410 name: right lateral chain of skeletogenic mesenchyme cell def: "The lateral chain that forms on the right side of the embryo from the right ventrolateral cluster." [] synonym: "right lateral chain of PMCs" EXACT [] is_a: ECAO:0106320 ! lateral chain of skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112420 name: left lateral chain of skeletogenic mesenchyme cell def: "The lateral chain that forms on the left side of the embryo from the left ventrolateral cluster." [] synonym: "left lateral chain of PMCs" EXACT [] is_a: ECAO:0106320 ! lateral chain of skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112430 name: triradiate spicule def: "A skeletal, calcified structure composed of three elongated skeletal rods." [] synonym: "triradiate element" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112440 name: ventrolateral spicule granule def: "A spicule granule that forms within a ventrolateral cluster of skeletogenic mesenchyme cells." [] is_a: ECAO:0105630 ! spicule granule is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0108060 ! ventrolateral skeletogenic mesenchyme cluster relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103820 ! embryonic endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112450 name: right ventrolateral spicule granule def: "A ventrolateral spicule granule that forms on the right side of the embryo." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0106300 ! right ventrolateral skeletogenic mesenchyme cluster property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112460 name: left ventrolateral spicule granule def: "A ventrolateral spicule granule that forms on the left side of the embryo." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0106310 ! left ventrolateral skeletogenic mesenchyme cluster property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112470 name: ventrolateral triradiate spicule rudiment def: "A triradiate spicule rudiment that forms within a ventrolateral cluster of skeletogenic mesenchyme cells." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0112440 ! ventrolateral spicule granule relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112480 name: presumptive non-skeletogenic mesoderm def: "An embryonic, larval or adult region that will develop into non-skeletogenic mesoderm and/or mesenchyme derivatives." [] is_a: ECAO:0106200 ! presumptive mesoderm relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000284 ! stage 11 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112490 name: non-skeletogenic mesoderm def: "The subset of the mesoderm germ layer that will give rise to all mesoderm tissue derivatives but the endoskeleton; e.g. muscles, coeloms, pigment cells, blastocoelar cells." [] is_a: ECAO:0106210 ! mesoderm relationship: develops_from ECAO:0112480 ! presumptive non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112500 name: non-skeletogenic mesoderm cell def: "A cell part of the mesoderm germ layer subset that will give rise to all mesoderm tissue derivatives but the endoskeleton; e.g. muscles, coeloms, pigment cells, blastocoelar cells." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0112490 ! non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112510 name: non-skeletogenic mesenchyme def: "All mesenchyme present in the embryo, larva, or adult but that does not constitute the endoskeleton." [] is_a: ECAO:0112280 ! mesenchyme relationship: develops_from ECAO:0112490 ! non-skeletogenic mesoderm relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112520 name: non-skeletogenic mesenchyme cell def: "A mesenchymal cell that participates in the elaboration of all mesenchyme derivatives but the endoskeleton; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112530 name: vegetal tier 2 non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that derives from the vegetal 2 tier cells and not from the small micromere descendants." [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000284 ! stage 11 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112540 name: embryonic mesenchyme cell def: "In echinoderms with no embryonic endoskeleton, all embryonic cells that have undergone an epithelial-to-mesenchymal transition and will participate in the elaboration of non-skeletogenic mesoderm derivatives; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112550 name: larval mesenchyme cell def: "In echinoderms with no larval endoskeleton, all larval mesenchyme cells that participate in the elaboration of non-skeletogenic mesoderm derivatives; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112560 name: oral presumptive non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that in the vegetal plate is on the oral side of the embryo." [] synonym: " oral non-skeletogenic mesoderm" EXACT [] synonym: " ventral non-skeletogenic mesoderm" EXACT [] synonym: "ventral presumptive embryonic non-skeletogenic mesoderm" EXACT [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112570 name: aboral presumptive non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that in the vegetal plate is on the aboral side of the embryo." [] synonym: " aboral non-skeletogenic mesoderm" EXACT [] synonym: " dorsal non-skeletogenic mesoderm" EXACT [] synonym: "dorsal presumptive embryonic non-skeletogenic mesoderm" EXACT [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112580 name: immune cell def: "A cell of the immune system that is involved in protecting the body against infectious disease and foreign invaders." [] synonym: "immunocyte" EXACT [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112590 name: phagocytic filopodial cell def: "The subset of the filopodial cells that are phagocytic and express the immune effector gene 185/333." [] is_a: ECAO:0106510 ! filopodial cell relationship: develops_from ECAO:0106490 ! blastocoelar cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112600 name: sphincter primordium def: "An initial constriction within the archenteron marking where a sphincter will form." [] synonym: " gut constriction" EXACT [] synonym: "sphincter constriction" EXACT [] is_a: ECAO:0112220 ! constriction relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112610 name: pyloric sphincter primordium def: "The initial constriction within the archenteron that will develop into the pyloric sphincter and separates the midgut and hindgut." [] synonym: " midgut-hindgut constriction" EXACT [] synonym: " pyloric constriction" EXACT [] synonym: "pyloric sphincter constriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112620 name: cardiac sphincter primordium def: "The initial constriction within the archenteron that will develop into the cardiac sphincter and separates the foregut and the midgut." [] synonym: " cardiac constriction" EXACT [] synonym: " foregut-midgut constriction" EXACT [] synonym: "cardiac sphincter constriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112630 name: anal sphincter primordium def: "The initial constriction at the posterior end of the archenteron (i.e. at the level of the blastopore) that will develop into the anal sphincter." [] synonym: " anal constriction" EXACT [] synonym: "anal sphincter contriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during GO:0002164 ! larval development relationship: existence_starts_during GO:0002164 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112640 name: sphincter cell def: "A cell that is part of a sphincter." [] synonym: "myoepithelial cell" EXACT [] is_a: ECAO:0108110 ! muscle cell relationship: existence_ends_during GO:0002164 ! larval development relationship: part_of ECAO:0106610 ! sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112650 name: pyloric sphincter cell def: "A cell that is part of a pyloric sphincter." [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112660 name: cardiac sphincter cell def: "A cell that is part of a cardiac sphincter." [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112670 name: anal sphincter cell def: "A cell that is part of an anal sphincter." [] synonym: "anal pore muscle cell" EXACT [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005773 ! vacuole relationship: results_in_distribution_of GO:0005773 ! vacuole property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] xref: Reactome:R-HSA-2500257 "Resolution of Sister Chromatid Cohesion" is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] synonym: "Golgi apparatus membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005794 ! Golgi apparatus relationship: bounding_layer_of GO:0005794 ! Golgi apparatus relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23114 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23195 xsd:anyURI [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18154 ! has primary output polysaccharide relationship: RO:0004008 CHEBI:18154 ! has primary output polysaccharide [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process alt_id: GO:0044244 def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic" xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division relationship: in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005634 ! nucleus relationship: results_in_fission_of GO:0005634 ! nucleus [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion intersection_of: RO:0012008 GO:0005634 ! results in fusion of nucleus relationship: part_of GO:0006997 ! nucleus organization relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation intersection_of: has_part GO:0045026 ! plasma membrane fusion [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0000789 alt_id: GO:0000790 alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005694 ! chromosome property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28301 xsd:anyURI [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component alt_id: GO:0005720 alt_id: GO:0035328 def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] synonym: "nuclear heterochromatin" NARROW [] synonym: "transcriptionally inactive chromatin" EXACT [] synonym: "transcriptionally silent chromatin" EXACT [] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22355 xsd:anyURI [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal system [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process intersection_of: GO:0006581 ! acetylcholine catabolic process intersection_of: BFO:0000066 GO:0043083 ! occurs in synaptic cleft relationship: BFO:0000066 GO:0043083 ! occurs in synaptic cleft relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048514 ! blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000023 ! results in growth of oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: RO:0002343 CL:0000023 ! results in growth of oocyte [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000023 ! results in maturation of oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016049 ! regulates cell growth relationship: RO:0002211 GO:0016049 ! regulates cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: part_of GO:0051716 ! cellular response to stimulus relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001944 ! vasculature development relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048514 ! blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0000057 GO:0005874 ! has participant microtubule relationship: RO:0002297 GO:0097427 ! results in formation of anatomical entity microtubule bundle [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0150063 ! visual system development relationship: RO:0002296 UBERON:0000970 ! results in development of eye [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004122 ! results in development of genitourinary system relationship: has_part GO:0072001 ! renal system development relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0004122 ! results in development of genitourinary system property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22178 xsd:anyURI [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: part_of CL:0000021 ! female germ cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of CL:0000021 ! female germ cell [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0006413 ! translational initiation relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex [Term] id: GO:0001678 name: intracellular glucose homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "cellular glucose homeostasis" EXACT [] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of D-glucopyranose [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: in_taxon NCBITaxon:50557 ! Insecta [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: in_taxon NCBITaxon:32525 ! Theria [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007369 ! gastrulation relationship: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm relationship: part_of GO:0007398 ! ectoderm development relationship: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9823730 "Formation of definitive endoderm" is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm relationship: part_of GO:0007492 ! endoderm development relationship: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm relationship: part_of GO:0048332 ! mesoderm morphogenesis relationship: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm [Term] id: GO:0001743 name: lens placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] synonym: "optic placode formation" RELATED [] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0048598 ! embryonic morphogenesis relationship: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0048749 ! compound eye development relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0001745 ! compound eye morphogenesis relationship: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell relationship: part_of GO:0048592 ! eye morphogenesis relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Reactome:R-HSA-9824272 "Somitogenesis" xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development relationship: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte [Term] id: GO:0001816 name: cytokine production namespace: biological_process alt_id: GO:0042032 alt_id: GO:0042089 alt_id: GO:0042107 alt_id: GO:0050663 def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cytokine biosynthetic process" NARROW [] synonym: "cytokine metabolic process" NARROW [] synonym: "cytokine secretion" NARROW [] synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0010467 ! gene expression is_a: GO:0032501 ! multicellular organismal process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19116 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process alt_id: GO:0042035 alt_id: GO:0050707 def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "regulation of cytokine anabolism" EXACT [] synonym: "regulation of cytokine biosynthesis" EXACT [] synonym: "regulation of cytokine biosynthetic process" NARROW [] synonym: "regulation of cytokine formation" EXACT [] synonym: "regulation of cytokine secretion" NARROW [] synonym: "regulation of cytokine synthesis" EXACT [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001816 ! regulates cytokine production relationship: RO:0002211 GO:0001816 ! regulates cytokine production property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process alt_id: GO:0042036 alt_id: GO:0050710 def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine biosynthetic process" EXACT [] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine biosynthetic process" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine biosynthetic process" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine biosynthetic process" NARROW [] synonym: "inhibition of cytokine production" NARROW [] synonym: "negative regulation of cytokine anabolism" EXACT [] synonym: "negative regulation of cytokine biosynthesis" EXACT [] synonym: "negative regulation of cytokine biosynthetic process" NARROW [] synonym: "negative regulation of cytokine formation" EXACT [] synonym: "negative regulation of cytokine secretion" NARROW [] synonym: "negative regulation of cytokine synthesis" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001816 ! negatively regulates cytokine production relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process alt_id: GO:0042108 alt_id: GO:0050715 def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "positive regulation of cytokine biosynthetic process" NARROW [] synonym: "positive regulation of cytokine secretion" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001816 ! positively regulates cytokine production relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. synonym: "blastula development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001701 ! in utero embryonic development relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29162 xsd:anyURI [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. synonym: "blastula formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001824 ! blastocyst development relationship: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29162 xsd:anyURI [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001825 ! blastocyst formation relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001825 ! blastocyst formation relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001829 ! trophectodermal cell differentiation relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. synonym: "blastula growth" RELATED [] is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001824 ! blastocyst development relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29162 xsd:anyURI [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001832 ! blastocyst growth relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001832 ! blastocyst growth relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] xref: Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation" is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell intersection_of: RO:0004009 CL:0000066 ! has primary input epithelial cell relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0001840 ! neural plate development relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0043009 ! chordate embryonic development relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0021915 ! neural tube development relationship: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0014020 ! primary neural tube formation relationship: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0045446 ! endothelial cell differentiation relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001885 ! endothelial cell development relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002107 ! results in development of liver relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061008 ! hepaticobiliary system development relationship: RO:0002296 UBERON:0002107 ! results in development of liver [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0072359 ! circulatory system development relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001568 ! blood vessel development relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion relationship: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0060429 ! epithelium development relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006814 ! regulates sodium ion transport relationship: RO:0002211 GO:0006814 ! regulates sodium ion transport [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0051216 ! cartilage development relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0002062 ! chondrocyte differentiation relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0030855 ! epithelial cell differentiation relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell relationship: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0002067 ! glandular epithelial cell differentiation relationship: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0002064 ! epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0002068 ! glandular epithelial cell development relationship: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060900 ! embryonic camera-type eye formation relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0043010 ! camera-type eye development relationship: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009850 ! results in development of nematode larva relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0009850 ! results in development of nematode larva [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030097 ! hemopoiesis relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18737 xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000763 ! acts on population of myeloid cell relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process alt_id: GO:0002374 alt_id: GO:0002375 def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "cytokine biosynthetic process involved in immune response" NARROW [] synonym: "cytokine production during immune response" RELATED [GOC:dph] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] synonym: "cytokine secretion involved in immune response" RELATED [] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0002251 ! organ or tissue specific immune response intersection_of: GO:0006955 ! immune response intersection_of: BFO:0000066 UBERON:0002107 ! occurs in liver relationship: BFO:0000066 UBERON:0002107 ! occurs in liver relationship: in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002405 ! results in development of immune system relationship: RO:0002296 UBERON:0002405 ! results in development of immune system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0030097 ! hemopoiesis relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002376 ! regulates immune system process relationship: RO:0002211 GO:0002376 ! regulates immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002376 ! negatively regulates immune system process relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002376 ! positively regulates immune system process relationship: RO:0002213 GO:0002376 ! positively regulates immune system process [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process relationship: RO:0002211 GO:0002252 ! regulates immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002252 ! negatively regulates immune effector process relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002252 ! positively regulates immune effector process relationship: RO:0002213 GO:0002252 ! positively regulates immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010629 ! negative regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010628 ! positive regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response relationship: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process alt_id: GO:0002739 alt_id: GO:0002742 def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process alt_id: GO:0002740 alt_id: GO:0002743 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "negative regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process alt_id: GO:0002741 alt_id: GO:0002744 def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "positive regulation of cytokine secretion involved in immune response" NARROW [] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002790 ! regulates peptide secretion relationship: RO:0002211 GO:0002790 ! regulates peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002790 ! negatively regulates peptide secretion relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002790 ! positively regulates peptide secretion relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035989 ! tendon development relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheath created_by: hjd creation_date: 2012-04-23T02:11:22Z [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007507 ! heart development relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] subset: goslim_drosophila subset: goslim_generic synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] subset: goslim_generic synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] subset: goslim_generic synonym: "respiratory gaseous exchange" EXACT [] is_a: GO:0003008 ! system process relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport intersection_of: GO:0006814 ! sodium ion transport intersection_of: BFO:0000066 UBERON:0001008 ! occurs in renal system relationship: BFO:0000066 UBERON:0001008 ! occurs in renal system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0000222 ! has start location mesodermal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell created_by: tb creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell intersection_of: RO:0002232 CL:0000222 ! has end location mesodermal cell relationship: RO:0002231 CL:0000223 ! has start location endodermal cell relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell created_by: tb creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate created_by: tb creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development relationship: part_of GO:0048562 ! embryonic organ morphogenesis relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube created_by: tb creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis relationship: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube created_by: tb creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation created_by: tb creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum relationship: part_of GO:0003151 ! outflow tract morphogenesis relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum created_by: tb creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060412 ! ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part created_by: tb creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060412 ! ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part created_by: tb creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract created_by: tb creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: part_of GO:0003144 ! embryonic heart tube formation relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tb creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation relationship: RO:0002211 GO:0048645 ! regulates animal organ formation created_by: tb creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium created_by: dph creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium created_by: dph creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003158 ! endothelium development relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium created_by: dph creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003157 ! endocardium development relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium created_by: dph creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart created_by: dph creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003161 ! cardiac conduction system development relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node created_by: dph creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node relationship: part_of GO:0003161 ! cardiac conduction system development relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node created_by: dph creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system relationship: in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of GO:0003161 ! cardiac conduction system development relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system created_by: dph creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber relationship: in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of GO:0003164 ! His-Purkinje system development relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber created_by: dph creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte relationship: part_of GO:0003165 ! Purkinje myocyte development relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte created_by: dph creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein created_by: dph creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion created_by: dph creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion created_by: dph creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton created_by: dph creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber created_by: dph creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber created_by: dph creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber created_by: dph creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle relationship: part_of GO:0003231 ! cardiac ventricle development relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle created_by: dph creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium relationship: part_of GO:0003230 ! cardiac atrium development relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium created_by: dph creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002081 ! results in formation of anatomical entity cardiac atrium relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: RO:0002297 UBERON:0002081 ! results in formation of anatomical entity cardiac atrium created_by: dph creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002082 ! results in formation of anatomical entity cardiac ventricle relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis relationship: RO:0002297 UBERON:0002082 ! results in formation of anatomical entity cardiac ventricle created_by: dph creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium created_by: dph creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium created_by: dph creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle created_by: dph creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle created_by: dph creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002079 ! results in formation of anatomical entity left cardiac atrium relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis relationship: RO:0002297 UBERON:0002079 ! results in formation of anatomical entity left cardiac atrium created_by: dph creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002078 ! results in formation of anatomical entity right cardiac atrium relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis relationship: RO:0002297 UBERON:0002078 ! results in formation of anatomical entity right cardiac atrium created_by: dph creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002084 ! results in formation of anatomical entity heart left ventricle relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis relationship: RO:0002297 UBERON:0002084 ! results in formation of anatomical entity heart left ventricle created_by: dph creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002080 ! results in formation of anatomical entity heart right ventricle relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis relationship: RO:0002297 UBERON:0002080 ! results in formation of anatomical entity heart right ventricle created_by: dph creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle created_by: dph creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle created_by: dph creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle relationship: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle created_by: dph creation_date: 2009-10-13T10:33:00Z [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium relationship: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium created_by: dph creation_date: 2009-10-13T10:45:09Z [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium relationship: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium created_by: dph creation_date: 2009-10-13T10:50:59Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22614 xsd:anyURI created_by: dph creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle created_by: dph creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium created_by: dph creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle created_by: dph creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosus created_by: dph creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus relationship: part_of GO:0003235 ! sinus venosus development relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus created_by: dph creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002063 ! results in formation of anatomical entity sinus venosus relationship: part_of GO:0003236 ! sinus venosus morphogenesis relationship: RO:0002297 UBERON:0002063 ! results in formation of anatomical entity sinus venosus created_by: dph creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth created_by: dph creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary created_by: dph creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002062 ! results in formation of anatomical entity endocardial cushion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: RO:0002297 UBERON:0002062 ! results in formation of anatomical entity endocardial cushion created_by: dph creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0003272 ! endocardial cushion formation relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003205 ! cardiac chamber development relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac septum created_by: dph creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum relationship: part_of GO:0003231 ! cardiac ventricle development relationship: RO:0002296 UBERON:0002094 ! results in development of interventricular septum created_by: dph creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum relationship: part_of GO:0003230 ! cardiac atrium development relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial septum created_by: dph creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003279 ! cardiac septum development relationship: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell created_by: dph creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0055017 ! cardiac muscle tissue growth created_by: dph creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031018 ! endocrine pancreas development relationship: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell created_by: dph creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031018 ! endocrine pancreas development relationship: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell created_by: dph creation_date: 2009-10-26T09:28:05Z [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031018 ! endocrine pancreas development relationship: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell created_by: dph creation_date: 2009-10-26T09:30:27Z [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031018 ! endocrine pancreas development relationship: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell created_by: dph creation_date: 2009-10-26T09:32:32Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035050 ! embryonic heart tube development relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudiment created_by: dph creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003313 ! heart rudiment development relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22938 xsd:anyURI created_by: dph creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004291 ! results in formation of anatomical entity heart rudiment relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003314 ! heart rudiment morphogenesis relationship: RO:0002297 UBERON:0004291 ! results in formation of anatomical entity heart rudiment created_by: dph creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000171 ! results in development of pancreatic A cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003310 ! pancreatic A cell differentiation relationship: RO:0002296 CL:0000171 ! results in development of pancreatic A cell created_by: dph creation_date: 2009-11-02T08:13:55Z [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003309 ! type B pancreatic cell differentiation relationship: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell created_by: dph creation_date: 2009-11-02T08:20:11Z [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000173 ! results in development of pancreatic D cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003311 ! pancreatic D cell differentiation relationship: RO:0002296 CL:0000173 ! results in development of pancreatic D cell created_by: dph creation_date: 2009-11-02T08:23:26Z [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003312 ! pancreatic PP cell differentiation relationship: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell created_by: dph creation_date: 2009-11-02T08:25:03Z [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion relationship: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:07:40Z [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion relationship: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:11:22Z [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion relationship: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:13:49Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion created_by: dph creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003343 ! septum transversum development relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardium created_by: dph creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum relationship: RO:0002296 UBERON:0004161 ! results in development of septum transversum created_by: dph creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060039 ! pericardium development relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium created_by: dph creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell relationship: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell created_by: dph creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron relationship: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron created_by: dph creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron relationship: part_of GO:0003357 ! noradrenergic neuron differentiation relationship: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron created_by: dph creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem created_by: dph creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation intersection_of: GO:0003357 ! noradrenergic neuron differentiation intersection_of: part_of GO:0003360 ! brainstem development relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003360 ! brainstem development created_by: dph creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0001667 ! ameboidal-type cell migration property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2009-12-08T05:42:46Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0042074 ! cell migration involved in gastrulation created_by: dph creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0007369 ! gastrulation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration created_by: dph creation_date: 2009-12-09T07:10:57Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: part_of GO:0007369 ! gastrulation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007369 ! gastrulation created_by: dph creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0002064 ! epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell created_by: dph creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004128 ! results in formation of anatomical entity optic vesicle relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation relationship: RO:0002297 UBERON:0004128 ! results in formation of anatomical entity optic vesicle created_by: dph creation_date: 2009-12-21T01:42:37Z [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle created_by: dph creation_date: 2009-12-21T01:54:34Z [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060041 ! retina development in camera-type eye relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer created_by: dph creation_date: 2009-12-21T02:15:14Z [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T03:04:27Z [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:39:58Z [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:42:55Z [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone created_by: dph creation_date: 2009-12-22T08:52:55Z [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T12:42:44Z [Term] id: GO:0003674 name: gene product or complex activity name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 ! process disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process property_value: editor_note "This is the same as GO molecular function" xsd:string [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "carrier" RELATED [] is_a: GO:0003674 ! molecular_function property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27621 xsd:anyURI [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005279 def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: part_of GO:0015837 ! amine transport relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine relationship: RO:0004009 CHEBI:15355 ! has primary input acetylcholine [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" xref: Reactome:R-HSA-372843 "SLC25A10 mediates exchange of malate and phosphate" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35692 ! has primary input dicarboxylic acid relationship: part_of GO:0006835 ! dicarboxylic acid transport relationship: RO:0004009 CHEBI:35692 ! has primary input dicarboxylic acid [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: part_of GO:0006869 {source="GO_REF:0000090"} ! lipid transport relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0005326 name: neurotransmitter transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] synonym: "neurotransmitter transporter activity" RELATED [] xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" is_a: GO:0022857 ! transmembrane transporter activity relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0006836 {source="GO_REF:0000090"} ! neurotransmitter transport [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: part_of GO:1903825 ! organic acid transmembrane transport relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 ! material entity disjoint_from: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17729 xsd:anyURI [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0005581 name: collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0005583 name: fibrillar collagen trimer namespace: cellular_component def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098643 ! banded collagen fibril disjoint_from: GO:0030936 ! transmembrane collagen trimer relationship: part_of GO:0098643 ! banded collagen fibril [Term] id: GO:0005585 name: collagen type II trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0005604 name: basement membrane namespace: cellular_component alt_id: GO:0005605 alt_id: GO:0008003 def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. synonym: "basal lamina" RELATED [] synonym: "basement lamina" RELATED [] synonym: "lamina densa" RELATED [] xref: Wikipedia:Basement_membrane is_a: GO:0031012 ! extracellular matrix property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29267 xsd:anyURI [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical structure relationship: part_of GO:0005576 ! extracellular region property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17776 xsd:anyURI [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm relationship: in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005634 ! nucleus relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29832 xsd:anyURI [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "nucleus outer envelope" EXACT [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005634 ! nucleus relationship: bounding_layer_of GO:0005634 ! nucleus relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular membraneless organelle relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23023 xsd:anyURI [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005773 ! vacuole relationship: bounding_layer_of GO:0005773 ! vacuole relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular membraneless organelle relationship: capable_of_part_of GO:0006412 ! translation relationship: has_part CHEBI:33697 ! ribonucleic acid relationship: has_part PR:000000001 ! protein [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005930 ! axoneme relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005930 ! axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005634 ! nucleus relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005887 alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "integral component of plasma membrane" NARROW [] synonym: "integral to plasma membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: has_part GO:0032432 ! actin filament bundle relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of CL:0000066 ! epithelial cell [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] synonym: "cell-cell contact region" BROAD [] synonym: "cell-cell contact zone" BROAD [] synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22122 xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0030990 ! intraciliary transport particle relationship: in_taxon NCBITaxon:2759 ! Eukaryota property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005930 name: axoneme namespace: cellular_component alt_id: GO:0035085 alt_id: GO:0035086 def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. subset: goslim_pir synonym: "ciliary axoneme" EXACT [] synonym: "cilium axoneme" EXACT [] synonym: "flagellar axoneme" EXACT [] synonym: "flagellum axoneme" EXACT [] xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical structure relationship: has_part GO:0005874 ! microtubule relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0097014 ! ciliary plasm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "ectoplasm" NARROW [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0071944 ! cell periphery relationship: part_of GO:0071944 ! cell periphery property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26298 xsd:anyURI [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:R-HSA-71387 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate relationship: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22880 xsd:anyURI created_by: jl creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process alt_id: GO:0044263 def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] subset: goslim_pir synonym: "glycan metabolic process" NARROW [] synonym: "glycan metabolism" NARROW [] synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide relationship: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] synonym: "glycogen metabolism" EXACT [] xref: Reactome:R-HSA-8982491 "Glycogen metabolism" is_a: GO:0006112 ! energy reserve metabolic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28087 ! has primary input or output glycogen relationship: RO:0004007 CHEBI:28087 ! has primary input or output glycogen [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:PWY-7900 {source="skos:narrowMatch"} xref: Reactome:R-HSA-3322077 "Glycogen synthesis" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:28087 ! has primary output glycogen relationship: RO:0004008 CHEBI:28087 ! has primary output glycogen property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27107 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28527 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28968 xsd:anyURI [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process relationship: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] synonym: "glycogenolysis" EXACT [GOC:sl] xref: MetaCyc:PWY-7662 {source="skos:narrowMatch"} xref: Reactome:R-HSA-70221 "Glycogen breakdown (glycogenolysis)" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:28087 ! has primary input glycogen relationship: RO:0004009 CHEBI:28087 ! has primary input glycogen property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27107 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28527 xsd:anyURI [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] synonym: "regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005980 ! regulates glycogen catabolic process relationship: RO:0002211 GO:0005980 ! regulates glycogen catabolic process [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35381 ! has primary input or output monosaccharide relationship: RO:0004007 CHEBI:35381 ! has primary input or output monosaccharide [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] xref: Reactome:R-HSA-70326 "Glucose metabolism" is_a: GO:0019318 ! hexose metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:4167 ! has primary input or output D-glucopyranose relationship: RO:0004007 CHEBI:4167 ! has primary input or output D-glucopyranose [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan relationship: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:22506 ! has primary output aminoglycan relationship: RO:0004008 CHEBI:22506 ! has primary output aminoglycan [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18085 ! has primary output glycosaminoglycan relationship: RO:0004008 CHEBI:18085 ! has primary output glycosaminoglycan property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29745 xsd:anyURI [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:22506 ! has primary input aminoglycan relationship: RO:0004009 CHEBI:22506 ! has primary input aminoglycan [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] xref: Reactome:R-HSA-2024101 "CS/DS degradation" is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18085 ! has primary input glycosaminoglycan relationship: RO:0004009 CHEBI:18085 ! has primary input glycosaminoglycan property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29745 xsd:anyURI [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output organic acid relationship: RO:0004007 CHEBI:64709 ! has primary input or output organic acid [Term] id: GO:0006083 name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:30089 ! has primary input or output acetate relationship: RO:0004007 CHEBI:30089 ! has primary input or output acetate [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY {source="skos:narrowMatch"} xref: MetaCyc:PWY-6142 {source="skos:narrowMatch"} xref: MetaCyc:PWY66-399 {source="skos:narrowMatch"} xref: Reactome:R-HSA-70263 "Gluconeogenesis" xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:4167 ! has primary output D-glucopyranose relationship: RO:0004008 CHEBI:4167 ! has primary output D-glucopyranose property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28953 xsd:anyURI [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process alt_id: GO:0090526 def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED [] synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006094 ! regulates gluconeogenesis relationship: RO:0002211 GO:0006094 ! regulates gluconeogenesis created_by: tb creation_date: 2013-01-18T12:47:43Z [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir synonym: "energy reserve metabolism" EXACT [] is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity relationship: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity [Term] id: GO:0006325 name: chromatin organization namespace: biological_process alt_id: GO:0006333 alt_id: GO:0006336 alt_id: GO:0016568 alt_id: GO:0031497 alt_id: GO:0034724 def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "chromatin assembly" NARROW [] synonym: "chromatin assembly or disassembly" RELATED [] synonym: "chromatin assembly/disassembly" RELATED [] synonym: "chromatin maintenance" BROAD [] synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "DNA replication-independent chromatin assembly" NARROW [] synonym: "DNA replication-independent chromatin organization" NARROW [] synonym: "DNA replication-independent nucleosome organisation" NARROW [] synonym: "DNA replication-independent nuclesome assembly" NARROW [] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] synonym: "transcription-coupled nucleosome assembly" NARROW [] xref: Reactome:R-HSA-4839726 "Chromatin organization" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin relationship: RO:0002592 GO:0000785 ! results in organization of chromatin property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22130 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23549 xsd:anyURI [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141188 ! nucleic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:R-HSA-72766 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: part_of GO:0010467 ! gene expression intersection_of: RO:0004008 CHEBI:36080 ! has primary output protein relationship: ends_with GO:0006415 ! translational termination relationship: has_part GO:0006414 ! translational elongation relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0010467 ! gene expression relationship: RO:0004008 CHEBI:36080 ! has primary output protein relationship: starts_with GO:0006413 ! translational initiation [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] xref: Reactome:R-HSA-72613 "Eukaryotic Translation Initiation" is_a: GO:0008152 ! metabolic process relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0006412 ! translation relationship: starts_with GO:0001677 ! formation of translation initiation ternary complex [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:R-HSA-156842 "Eukaryotic Translation Elongation" is_a: GO:0009059 ! macromolecule biosynthetic process relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: Reactome:R-HSA-72764 "Eukaryotic Translation Termination" is_a: GO:0032984 ! protein-containing complex disassembly relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: RO:0002211 GO:0006412 ! regulates translation [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation relationship: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation relationship: RO:0002211 GO:0006414 ! regulates translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006415 ! regulates translational termination relationship: RO:0002211 GO:0006415 ! regulates translational termination [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17089 ! has primary input glycoprotein relationship: RO:0004009 CHEBI:17089 ! has primary input glycoprotein [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] xref: Reactome:R-HSA-2980736 "Peptide hormone metabolism" is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion relationship: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion [Term] id: GO:0006520 name: amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "amino acid and derivative metabolism" RELATED [] synonym: "cellular amino acid and derivative metabolic process" RELATED [] synonym: "cellular amino acid metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion relationship: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17904 xsd:anyURI [Term] id: GO:0006521 name: regulation of amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] xref: Reactome:R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006520 ! regulates amino acid metabolic process relationship: RO:0002211 GO:0006520 ! regulates amino acid metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0006576 name: biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine metabolism" EXACT [] synonym: "cellular biogenic amine metabolic process" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine relationship: RO:0004009 CHEBI:15355 ! has primary input acetylcholine [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine metabolism" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33567 ! has primary input or output catecholamine relationship: RO:0004007 CHEBI:33567 ! has primary input or output catecholamine [Term] id: GO:0006586 name: indolalkylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] synonym: "indolalkylamine metabolism" EXACT [] synonym: "indolamine metabolic process" BROAD [] synonym: "indolamine metabolism" BROAD [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:38631 ! has primary input or output aminoalkylindole relationship: RO:0004007 CHEBI:38631 ! has primary input or output aminoalkylindole [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:R-HSA-556833 "Metabolism of lipids" xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid relationship: RO:0004007 CHEBI:18059 ! has primary input or output lipid [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid relationship: BFO:0000066 GO:0016020 ! occurs in membrane property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35341 ! has primary output steroid relationship: RO:0004008 CHEBI:35341 ! has primary output steroid [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] xref: Reactome:R-HSA-192105 "Synthesis of bile acids and bile salts" is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:36235 ! has primary output bile acid anion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0004008 CHEBI:36235 ! has primary output bile acid anion [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35341 ! has primary input steroid relationship: RO:0004009 CHEBI:35341 ! has primary input steroid [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26835 ! has primary input or output sulfur molecular entity relationship: RO:0004007 CHEBI:26835 ! has primary input or output sulfur molecular entity [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "single-organism transport" RELATED [] xref: Reactome:R-HSA-382551 "Transport of small molecules" is_a: GO:0051234 ! establishment of localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20292 xsd:anyURI created_by: jl creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: monoatomic ion transport namespace: biological_process def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "ion transport" BROAD [] xref: Reactome:R-HSA-425393 "Transport of inorganic cations/anions and amino acids/oligopeptides" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion [Term] id: GO:0006812 name: monoatomic cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 alt_id: GO:0072512 def: "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai] synonym: "cation transport" BROAD [] synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] synonym: "trivalent inorganic cation transport" NARROW [] is_a: GO:0006811 ! monoatomic ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:23906 ! has primary input monoatomic cation relationship: RO:0004009 CHEBI:23906 ! has primary input monoatomic cation [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29101 ! has primary input sodium(1+) relationship: RO:0004009 CHEBI:29101 ! has primary input sodium(1+) [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] xref: Reactome:R-HSA-181429 "Serotonin Neurotransmitter Release Cycle" xref: Reactome:R-HSA-181430 "Norepinephrine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-210500 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:R-HSA-212676 "Dopamine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-264642 "Acetylcholine Neurotransmitter Release Cycle" is_a: GO:0006810 ! transport relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) relationship: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) [Term] id: GO:0006846 name: acetate transport namespace: biological_process def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate relationship: RO:0004009 CHEBI:30089 ! has primary input acetate [Term] id: GO:0006847 name: plasma membrane acetate transport namespace: biological_process def: "The directed movement of acetate across a plasma membrane." [GOC:ai] is_a: GO:0035433 ! acetate transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport intersection_of: GO:0006865 ! amino acid transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-352230 "Amino acid transport across the plasma membrane" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-1369062 "ABC transporters in lipid homeostasis" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: part_of GO:0010876 ! lipid localization relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0006873 name: intracellular monoatomic ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] subset: goslim_yeast synonym: "cellular ion homeostasis" BROAD [] synonym: "cellular monoatomic ion homeostasis" EXACT [] is_a: GO:0050801 ! monoatomic ion homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of monoatomic ion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24455 xsd:anyURI [Term] id: GO:0006883 name: intracellular sodium ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell." [GOC:ai, GOC:mah] synonym: "cellular sodium ion homeostasis" EXACT [] is_a: GO:0030003 ! intracellular monoatomic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:29101 ! regulates levels of sodium(1+) [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: goslim_generic subset: goslim_prokaryote synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle relationship: has_part GO:0099500 ! vesicle fusion to plasma membrane relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: Reactome:R-HSA-199992 "trans-Golgi Network Vesicle Budding" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0005773 ! has target end location vacuole [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:R-HSA-109581 "Apoptosis" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death relationship: ends_with GO:0097194 ! execution phase of apoptosis relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: starts_with GO:0097190 ! apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: part_of GO:0097194 ! execution phase of apoptosis relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: part_of GO:0097194 ! execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] subset: goslim_pir xref: Reactome:R-HSA-445355 "Smooth Muscle Contraction" xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction relationship: RO:0002211 GO:0006936 ! regulates muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000228 ! results in formation of anatomical entity multinucleate cell relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: RO:0002297 CL:0000228 ! results in formation of anatomical entity multinucleate cell [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26810 xsd:anyURI [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] xref: Reactome:R-HSA-1852241 "Organelle biogenesis and maintenance" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043226 ! results in organization of organelle relationship: RO:0002592 GO:0043226 ! results in organization of organelle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005634 ! results in organization of nucleus relationship: RO:0002592 GO:0005634 ! results in organization of nucleus [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005635 ! results in organization of nuclear envelope relationship: part_of GO:0006997 ! nucleus organization relationship: part_of GO:0010256 ! endomembrane system organization relationship: RO:0002592 GO:0005635 ! results in organization of nuclear envelope [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005730 ! results in organization of nucleolus relationship: RO:0002592 GO:0005730 ! results in organization of nucleolus [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005886 ! results in organization of plasma membrane relationship: part_of GO:0010256 ! endomembrane system organization relationship: RO:0002592 GO:0005886 ! results in organization of plasma membrane [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005856 ! results in organization of cytoskeleton relationship: RO:0002592 GO:0005856 ! results in organization of cytoskeleton [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005884 ! results in organization of actin filament relationship: part_of GO:0030036 ! actin cytoskeleton organization relationship: RO:0002592 GO:0005884 ! results in organization of actin filament [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] subset: goslim_drosophila subset: goslim_generic xref: Reactome:R-HSA-983189 "Kinesins" is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] synonym: "microtubule shortening" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005874 ! results in disassembly of microtubule relationship: RO:0002590 GO:0005874 ! results in disassembly of microtubule [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0046785 ! microtubule polymerization [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization relationship: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization relationship: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005737 ! results in organization of cytoplasm relationship: RO:0002592 GO:0005737 ! results in organization of cytoplasm [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi apparatus organization" EXACT [] synonym: "Golgi organisation" EXACT [] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus relationship: part_of GO:0010256 ! endomembrane system organization relationship: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005773 ! results in organization of vacuole relationship: RO:0002592 GO:0005773 ! results in organization of vacuole [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0034329 ! cell junction assembly intersection_of: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction relationship: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell-division cycle" EXACT [] xref: Reactome:R-HSA-1640170 "Cell Cycle" xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] xref: Reactome:R-HSA-2299718 "Condensation of Prophase Chromosomes" xref: Reactome:R-HSA-2514853 "Condensation of Prometaphase Chromosomes" is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear membrane disassembly namespace: biological_process def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252] synonym: "local NEB" BROAD [] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" RELATED [] synonym: "mitotic nuclear envelope degradation" RELATED [] synonym: "mitotic nuclear envelope disassembly" RELATED [] synonym: "NEB" BROAD [] synonym: "nuclear envelope breakdown" BROAD [] xref: Reactome:R-HSA-2980766 "Nuclear Envelope Breakdown" is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140014 ! regulates mitotic nuclear division relationship: RO:0002211 GO:0140014 ! regulates mitotic nuclear division [Term] id: GO:0007097 name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0007292 ! female gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023014 alt_id: GO:0023015 alt_id: GO:0023016 alt_id: GO:0023033 alt_id: GO:0023045 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [] xref: Reactome:R-HSA-212718 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0023052 ! signaling relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: chemical synaptic transmission namespace: biological_process def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] subset: goslim_synapse synonym: "neurotransmission" RELATED [GOC:dph] synonym: "signal transmission across a synapse" BROAD [] synonym: "synaptic transmission" BROAD [] xref: Reactome:R-HSA-112316 "Neuronal System" xref: Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase" xref: Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" xref: Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling" xref: Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors" xref: Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor" xref: Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs" xref: Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs" xref: Reactome:R-HSA-9620244 "Long-term potentiation" xref: Wikipedia:Neurotransmission is_a: GO:0098916 ! anterograde trans-synaptic signaling relationship: RO:0000057 GO:0045202 ! has participant synapse [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process alt_id: GO:0010554 def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph] comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. subset: goslim_synapse synonym: "neurotransmitter release" EXACT [] synonym: "neurotransmitter secretory pathway" EXACT [] xref: Reactome:R-HSA-112310 "Neurotransmitter release cycle" is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099643 ! signal release from synapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: part_of GO:0007268 ! chemical synaptic transmission relationship: RO:0002338 GO:0098793 ! has target start location presynapse relationship: RO:0002339 GO:0043083 ! has target end location synaptic cleft [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] synonym: "cholinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: RO:0000057 CHEBI:15355 ! has participant acetylcholine [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21234 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "gametogenesis" NARROW [] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] xref: Reactome:R-HSA-9827857 "Specification of primordial germ cells" is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000586 ! results in development of germ cell relationship: part_of GO:0007276 ! gamete generation relationship: RO:0002296 CL:0000586 ! results in development of germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007308 name: oocyte construction namespace: biological_process alt_id: GO:0048110 def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002297 CL:0000023 ! results in formation of anatomical entity oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: RO:0002297 CL:0000023 ! results in formation of anatomical entity oocyte [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-2465910 "MASTL Facilitates Mitotic Progression" xref: Reactome:R-HSA-68911 "G2 Phase" is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000278 ! regulates mitotic cell cycle relationship: RO:0002211 GO:0000278 ! regulates mitotic cell cycle [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] subset: goslim_drosophila xref: Reactome:R-HSA-9758941 "Gastrulation" xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis relationship: has_part GO:0001705 ! ectoderm formation relationship: has_part GO:0001706 ! endoderm formation relationship: has_part GO:0001707 ! mesoderm formation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] subset: goslim_drosophila synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032501 ! multicellular organismal process relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007275 ! multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000924 ! results in development of ectoderm relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0000924 ! results in development of ectoderm [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] xref: Reactome:R-HSA-9675108 "Nervous system development" is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001016 ! results in development of nervous system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0001016 ! results in development of nervous system [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process alt_id: GO:0043349 alt_id: GO:0043350 def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048699 ! generation of neurons relationship: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation relationship: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] subset: goslim_synapse synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0034329 ! cell junction assembly is_a: GO:0050808 ! synapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0045202 ! results in assembly of synapse relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002588 GO:0045202 ! results in assembly of synapse [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001017 ! results in development of central nervous system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002296 UBERON:0001017 ! results in development of central nervous system [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000955 ! results in development of brain relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0060322 ! head development relationship: RO:0002296 UBERON:0000955 ! results in development of brain [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] subset: goslim_drosophila synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000020 ! results in development of sense organ relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002296 UBERON:0000020 ! results in development of sense organ [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002297 UBERON:0004906 ! results in formation of anatomical entity ectodermal part of digestive tract relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002297 UBERON:0004906 ! results in formation of anatomical entity ectodermal part of digestive tract [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001046 ! results in morphogenesis of hindgut relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0061525 ! hindgut development relationship: RO:0002298 UBERON:0001046 ! results in morphogenesis of hindgut [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000925 ! results in development of endoderm relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0000925 ! results in development of endoderm [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] is_a: GO:0048565 ! digestive tract development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001045 ! results in development of midgut relationship: RO:0002296 UBERON:0001045 ! results in development of midgut [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000926 ! results in development of mesoderm relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0000926 ! results in development of mesoderm [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme relationship: part_of GO:0008406 ! gonad development relationship: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0072359 ! circulatory system development relationship: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] is_a: GO:0048513 ! animal organ development is_a: GO:0061061 ! muscle structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001630 ! results in development of muscle organ relationship: RO:0002296 UBERON:0001630 ! results in development of muscle organ [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process alt_id: GO:0048637 def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060538 ! skeletal muscle organ development relationship: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] synonym: "neuromuscular junction organization" EXACT [] synonym: "neuromuscular junction stability" RELATED [GOC:pr] synonym: "NMJ stability" RELATED [GOC:pr] is_a: GO:0050808 ! synapse organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction relationship: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Reactome:R-HSA-8935690 "Digestion" xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: gocheck_do_not_annotate subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22368 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] subset: goslim_drosophila xref: Reactome:R-HSA-9709957 "Sensory Perception" xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Reactome:R-HSA-9659379 "Sensory processing of sound" xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007610 name: behavior namespace: biological_process alt_id: GO:0023032 alt_id: GO:0044708 alt_id: GO:0044709 def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0032501 ! multicellular organismal process disjoint_from: GO:0032502 ! developmental process relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002608 UBERON:0001016 ! process has causal agent nervous system created_by: jl creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: goslim_drosophila synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060047 ! regulates heart contraction relationship: RO:0002211 GO:0060047 ! regulates heart contraction [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0008505 def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid relationship: part_of GO:0015718 ! monocarboxylic acid transport relationship: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid [Term] id: GO:0008088 name: axo-dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" NARROW [] synonym: "axonal transport" NARROW [] synonym: "axoplasmic transport" NARROW [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0043005 ! occurs in neuron projection relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 alt_id: GO:0016249 alt_id: GO:0034613 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "cellular protein localization" EXACT [] synonym: "channel localizer activity" NARROW [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] xref: Reactome:R-HSA-9609507 "Protein localization" is_a: GO:0070727 ! cellular macromolecule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0008150 name: biological process name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 ! process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24968 xsd:anyURI created_by: jl creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote_ribbon synonym: "metabolism" EXACT [] xref: Reactome:R-HSA-1430728 "Metabolism" xref: Wikipedia:Metabolism is_a: GO:0009987 ! cellular process disjoint_from: GO:0051179 ! localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28932 xsd:anyURI created_by: jl creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] synonym: "steroid metabolism" EXACT [] xref: Reactome:R-HSA-8957322 "Metabolism of steroids" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35341 ! has primary input or output steroid relationship: RO:0004007 CHEBI:35341 ! has primary input or output steroid [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] xref: Reactome:R-HSA-194068 "Bile acid and bile salt metabolism" is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:36235 ! has primary input or output bile acid anion relationship: RO:0004007 CHEBI:36235 ! has primary input or output bile acid anion [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24680 xsd:anyURI [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008283 ! positively regulates cell population proliferation relationship: RO:0002213 GO:0008283 ! positively regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation relationship: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:1900619 ! acetate ester metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15355 ! has primary input or output acetylcholine relationship: RO:0004007 CHEBI:15355 ! has primary input or output acetylcholine [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:1900620 ! acetate ester biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:15355 ! has primary output acetylcholine relationship: RO:0004008 CHEBI:15355 ! has primary output acetylcholine [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function alt_id: GO:0015266 alt_id: GO:0015463 def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] synonym: "protein channel activity" RELATED [] xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix" xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol" xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol" xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation" xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation" is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0140318 ! protein transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: part_of GO:0071806 {source="GO_REF:0000090"} ! protein transmembrane transport [Term] id: GO:0008324 name: monoatomic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "cation transmembrane transporter activity" BROAD [] synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input monoatomic cation relationship: part_of GO:0098655 ! monoatomic cation transmembrane transport relationship: RO:0004009 CHEBI:23906 ! has primary input monoatomic cation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24479 xsd:anyURI [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] synonym: "gonadogenesis" EXACT [GOC:cjm] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000991 ! results in development of gonad relationship: part_of GO:0045137 ! development of primary sexual characteristics relationship: RO:0002296 UBERON:0000991 ! results in development of gonad property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015201 def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" is_a: GO:0022804 ! active transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine relationship: part_of GO:0015844 ! monoamine transport relationship: RO:0004009 CHEBI:63534 ! has primary input monoamine [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" xref: Reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids" xref: Reactome:R-HSA-9794830 "SLC22A8 transports Cipro into renal cell" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25696 ! has primary input organic anion relationship: part_of GO:0015711 ! organic anion transport relationship: RO:0004009 CHEBI:25696 ! has primary input organic anion [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0008585 name: female gonad development namespace: biological_process alt_id: GO:0061039 def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] is_a: GO:0008406 ! gonad development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000992 ! results in development of ovary relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0046545 ! development of primary female sexual characteristics relationship: RO:0002296 UBERON:0000992 ! results in development of ovary [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell relationship: part_of GO:0042461 ! photoreceptor cell development relationship: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid relationship: RO:0004008 CHEBI:18059 ! has primary output lipid [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "sugar transport" NARROW [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0008645 name: hexose transmembrane transport namespace: biological_process alt_id: GO:0008646 alt_id: GO:0008647 alt_id: GO:0035428 def: "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hexose membrane transport" RELATED [] synonym: "hexose transport" RELATED [] synonym: "high-affinity hexose transport" NARROW [] synonym: "low-affinity hexose transport" NARROW [] xref: Reactome:R-HSA-189200 "Cellular hexose transport" is_a: GO:0015749 ! monosaccharide transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:18133 ! has primary input hexose relationship: RO:0004009 CHEBI:18133 ! has primary input hexose created_by: bf creation_date: 2010-04-08T10:27:23Z [Term] id: GO:0008652 name: amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid anabolism" EXACT [] synonym: "amino acid biosynthesis" EXACT [] synonym: "amino acid formation" EXACT [] synonym: "amino acid synthesis" EXACT [] synonym: "cellular amino acid biosynthetic process" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion relationship: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17904 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27304 xsd:anyURI [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_plant subset: goslim_plant_ribbon synonym: "breakdown of chemical" EXACT [] synonym: "breakdown of molecule" EXACT [] synonym: "breakdown of substance" EXACT [] synonym: "catabolism" EXACT [] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28921 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28932 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29627 xsd:anyURI created_by: jl creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 alt_id: GO:0044266 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule catabolic process" RELATED [] synonym: "cellular macromolecule catabolism" RELATED [] synonym: "cellular macromolecule degradation" RELATED [] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0009056 ! catabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28932 xsd:anyURI created_by: jl creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule relationship: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15249 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25418 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI [Term] id: GO:0009063 name: amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid breakdown" EXACT [] synonym: "amino acid catabolism" EXACT [] synonym: "amino acid degradation" EXACT [] synonym: "cellular amino acid catabolic process" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17904 xsd:anyURI [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17089 ! has primary input or output glycoprotein relationship: RO:0004007 CHEBI:17089 ! has primary input or output glycoprotein [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17089 ! has primary output glycoprotein relationship: RO:0004008 CHEBI:17089 ! has primary output glycoprotein [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase relationship: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:37163 ! has primary output glucan relationship: RO:0004008 CHEBI:37163 ! has primary output glucan [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:37163 ! has primary input glucan relationship: RO:0004009 CHEBI:37163 ! has primary input glucan [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process alt_id: GO:0044106 def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32952 ! has primary input or output amine relationship: RO:0004007 CHEBI:32952 ! has primary input or output amine created_by: jl creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32952 ! has primary output amine relationship: RO:0004008 CHEBI:32952 ! has primary output amine [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant is_a: GO:0009314 ! response to radiation intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30212 ! has primary input photon relationship: RO:0004009 CHEBI:30212 ! has primary input photon [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: RO:0002297 CL:0010017 ! results in formation of anatomical entity zygote intersection_of: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0019953 ! sexual reproduction relationship: RO:0002297 CL:0010017 ! results in formation of anatomical entity zygote relationship: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20176 xsd:anyURI [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "chemoreception" RELATED [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0051606 ! detection of stimulus relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009620 name: response to fungus namespace: biological_process alt_id: GO:0009621 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi relationship: RO:0004009 NCBITaxon:4751 ! has primary input Fungi property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16572 xsd:anyURI [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process disjoint_from: GO:0048856 ! anatomical structure development disjoint_from: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009712 name: catechol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] synonym: "catechol metabolic process" RELATED [] synonym: "catechol metabolism" RELATED [] is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33566 ! has primary input or output catechols relationship: RO:0004007 CHEBI:33566 ! has primary input or output catechols [Term] id: GO:0009713 name: catechol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol anabolism" RELATED [] synonym: "catechol biosynthesis" RELATED [] synonym: "catechol biosynthetic process" RELATED [] synonym: "catechol formation" RELATED [] synonym: "catechol synthesis" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33566 ! has primary output catechols relationship: RO:0004008 CHEBI:33566 ! has primary output catechols [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0042221 ! response to chemical property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0009746 name: response to hexose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] synonym: "response to hexose stimulus" EXACT [GOC:dos] is_a: GO:0034284 ! response to monosaccharide intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18133 ! has primary input hexose relationship: RO:0004009 CHEBI:18133 ! has primary input hexose [Term] id: GO:0009749 name: response to glucose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] synonym: "response to glucose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008356 ! regulates asymmetric cell division relationship: RO:0002211 GO:0008356 ! regulates asymmetric cell division [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Reactome:R-HSA-5619507 "Activation of HOX genes during differentiation" xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000922 ! results in development of embryo relationship: RO:0002296 UBERON:0000922 ! results in development of embryo property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007275 ! multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:22315 ! has primary input or output alkaloid relationship: RO:0004007 CHEBI:22315 ! has primary input or output alkaloid [Term] id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:22315 ! has primary output alkaloid relationship: RO:0004008 CHEBI:22315 ! has primary output alkaloid [Term] id: GO:0009822 name: alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] synonym: "alkaloid breakdown" EXACT [] synonym: "alkaloid catabolism" EXACT [] synonym: "alkaloid degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009820 ! alkaloid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid relationship: RO:0004009 CHEBI:22315 ! has primary input alkaloid [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048513 ! animal organ development relationship: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000479 ! results in development of tissue relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: RO:0002296 UBERON:0000479 ! results in development of tissue property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009058 ! regulates biosynthetic process relationship: RO:0002211 GO:0009058 ! regulates biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process relationship: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009058 ! positively regulates biosynthetic process relationship: RO:0002213 GO:0009058 ! positively regulates biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008152 ! negatively regulates metabolic process relationship: RO:0002212 GO:0008152 ! negatively regulates metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008152 ! positively regulates metabolic process relationship: RO:0002213 GO:0008152 ! positively regulates metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process relationship: RO:0002211 GO:0009056 ! regulates catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009056 ! negatively regulates catabolic process relationship: RO:0002212 GO:0009056 ! negatively regulates catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009056 ! positively regulates catabolic process relationship: RO:0002213 GO:0009056 ! positively regulates catabolic process [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process alt_id: GO:0043355 def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0008544 ! epidermis development relationship: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007165 ! regulates signal transduction relationship: RO:0002211 GO:0007165 ! regulates signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007165 ! positively regulates signal transduction relationship: RO:0002213 GO:0007165 ! positively regulates signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] xref: Reactome:R-HSA-8849472 "PTK6 Down-Regulation" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007165 ! negatively regulates signal transduction relationship: RO:0002212 GO:0007165 ! negatively regulates signal transduction [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048477 ! oogenesis relationship: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process alt_id: GO:0007404 alt_id: GO:0043360 def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0042063 ! gliogenesis relationship: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast relationship: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0010034 name: response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate relationship: RO:0004009 CHEBI:30089 ! has primary input acetate [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] xref: Reactome:R-HSA-5660526 "Response to metal ions" is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25213 ! has primary input metal cation relationship: RO:0004009 CHEBI:25213 ! has primary input metal cation [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote relationship: RO:0004009 CL:0000365 ! has primary input animal zygote [Term] id: GO:0010160 name: formation of animal organ boundary namespace: biological_process alt_id: GO:0048862 def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048859 ! formation of anatomical boundary intersection_of: BFO:0000066 UBERON:0000062 ! occurs in organ relationship: BFO:0000066 UBERON:0000062 ! occurs in organ relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048645 ! animal organ formation [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0012505 ! results in organization of endomembrane system relationship: RO:0002592 GO:0012505 ! results in organization of endomembrane system [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045165 ! regulates cell fate commitment relationship: RO:0002211 GO:0045165 ! regulates cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment relationship: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045165 ! positively regulates cell fate commitment relationship: RO:0002213 GO:0045165 ! positively regulates cell fate commitment [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell relationship: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation relationship: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0009059 ! macromolecule biosynthetic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22557 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25419 xsd:anyURI [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant_ribbon synonym: "gene regulation" RELATED [GOC:cjm] synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Reactome:R-HSA-163767 "PP2A-mediated dephosphorylation of key metabolic factors" xref: Reactome:R-HSA-9752946 "Expression and translocation of olfactory receptors" xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010467 ! regulates gene expression relationship: RO:0002211 GO:0010467 ! regulates gene expression property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22557 xsd:anyURI [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007369 ! regulates gastrulation relationship: RO:0002211 GO:0007369 ! regulates gastrulation [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000362 ! has primary input epidermal cell relationship: RO:0004009 CL:0000362 ! has primary input epidermal cell [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010481 ! regulates epidermal cell division relationship: RO:0002211 GO:0010481 ! regulates epidermal cell division [Term] id: GO:0010496 name: intercellular transport namespace: biological_process alt_id: GO:1902585 def: "The movement of substances between cells." [GOC:dhl] synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intercellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 CL:0000000 ! has target start location cell intersection_of: RO:0002339 CL:0000000 ! has target end location cell intersection_of: RO:0002342 GO:0005615 ! results in transport across extracellular space relationship: RO:0002338 CL:0000000 ! has target start location cell relationship: RO:0002339 CL:0000000 ! has target end location cell relationship: RO:0002342 GO:0005615 ! results in transport across extracellular space created_by: jl creation_date: 2013-12-19T13:24:56Z [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030397 ! regulates membrane disassembly relationship: RO:0002211 GO:0030397 ! regulates membrane disassembly [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process relationship: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process relationship: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process relationship: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process relationship: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process relationship: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process relationship: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022402 ! regulates cell cycle process relationship: RO:0002211 GO:0022402 ! regulates cell cycle process [Term] id: GO:0010565 name: regulation of ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042180 ! regulates ketone metabolic process relationship: RO:0002211 GO:0042180 ! regulates ketone metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process relationship: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042182 ! regulates ketone catabolic process relationship: RO:0002211 GO:0042182 ! regulates ketone catabolic process [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process relationship: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process relationship: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process [Term] id: GO:0010608 name: post-transcriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] synonym: "posttranscriptional regulation of gene expression" EXACT [] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy relationship: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation relationship: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy relationship: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy relationship: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation relationship: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation relationship: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: part_of GO:0048468 ! cell development relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010467 ! positively regulates gene expression relationship: RO:0002213 GO:0010467 ! positively regulates gene expression property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22557 xsd:anyURI [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. synonym: "gene silencing" RELATED [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010467 ! negatively regulates gene expression relationship: RO:0002212 GO:0010467 ! negatively regulates gene expression property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22557 xsd:anyURI [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006996 ! positively regulates organelle organization relationship: RO:0002213 GO:0006996 ! positively regulates organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006996 ! negatively regulates organelle organization relationship: RO:0002212 GO:0006996 ! negatively regulates organelle organization [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007154 ! regulates cell communication relationship: RO:0002211 GO:0007154 ! regulates cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007154 ! positively regulates cell communication relationship: RO:0002213 GO:0007154 ! positively regulates cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007154 ! negatively regulates cell communication relationship: RO:0002212 GO:0007154 ! negatively regulates cell communication [Term] id: GO:0010656 name: negative regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process relationship: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010657 name: muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "muscle cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0010658 name: striated muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "striated muscle cell apoptosis" NARROW [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000737 ! occurs in striated muscle cell relationship: BFO:0000066 CL:0000737 ! occurs in striated muscle cell [Term] id: GO:0010659 name: cardiac muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010658 ! striated muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell [Term] id: GO:0010660 name: regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of muscle cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process relationship: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010661 name: positive regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process relationship: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010662 name: regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process relationship: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process relationship: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process relationship: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process relationship: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process relationship: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process relationship: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007398 ! ectoderm development relationship: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion relationship: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion relationship: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030574 ! regulates collagen catabolic process relationship: RO:0002211 GO:0030574 ! regulates collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process relationship: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032963 ! regulates collagen metabolic process relationship: RO:0002211 GO:0032963 ! regulates collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process relationship: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process relationship: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly relationship: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly relationship: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition relationship: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition relationship: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition relationship: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048468 ! positively regulates cell development relationship: RO:0002213 GO:0048468 ! positively regulates cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048468 ! negatively regulates cell development relationship: RO:0002212 GO:0048468 ! negatively regulates cell development [Term] id: GO:0010765 name: positive regulation of sodium ion transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006814 ! positively regulates sodium ion transport relationship: RO:0002213 GO:0006814 ! positively regulates sodium ion transport [Term] id: GO:0010766 name: negative regulation of sodium ion transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006814 ! negatively regulates sodium ion transport relationship: RO:0002212 GO:0006814 ! negatively regulates sodium ion transport [Term] id: GO:0010770 name: positive regulation of cell morphogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis relationship: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24299 xsd:anyURI [Term] id: GO:0010771 name: negative regulation of cell morphogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis relationship: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24299 xsd:anyURI [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010827 name: regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] synonym: "regulation of glucose transmembrane transport" EXACT [] synonym: "regulation of glucose transport" RELATED [] is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport relationship: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport [Term] id: GO:0010828 name: positive regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of glucose transmembrane transport" EXACT [] synonym: "positive regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of D-glucose transmembrane transport is_a: GO:0034764 ! positive regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport relationship: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport [Term] id: GO:0010829 name: negative regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of glucose transmembrane transport" EXACT [] synonym: "negative regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of D-glucose transmembrane transport is_a: GO:0034763 ! negative regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport relationship: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014902 ! regulates myotube differentiation relationship: RO:0002211 GO:0014902 ! regulates myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014902 ! positively regulates myotube differentiation relationship: RO:0002213 GO:0014902 ! positively regulates myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation relationship: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001781 ! results in formation of anatomical entity layer of retina relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye relationship: RO:0002297 UBERON:0001781 ! results in formation of anatomical entity layer of retina [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process relationship: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process relationship: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process [Term] id: GO:0010906 name: regulation of glucose metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006006 ! regulates glucose metabolic process relationship: RO:0002211 GO:0006006 ! regulates glucose metabolic process [Term] id: GO:0010907 name: positive regulation of glucose metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006006 ! positively regulates glucose metabolic process relationship: RO:0002213 GO:0006006 ! positively regulates glucose metabolic process [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular anatomical entity morphogenesis [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization relationship: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022402 ! negatively regulates cell cycle process relationship: RO:0002212 GO:0022402 ! negatively regulates cell cycle process created_by: tb creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030001 ! regulates metal ion transport relationship: RO:0002211 GO:0030001 ! regulates metal ion transport created_by: tb creation_date: 2009-05-06T11:40:55Z [Term] id: GO:0010962 name: regulation of glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009250 ! regulates glucan biosynthetic process relationship: RO:0002211 GO:0009250 ! regulates glucan biosynthetic process created_by: tb creation_date: 2009-05-11T12:17:53Z [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0031113 ! regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007020 ! regulates microtubule nucleation relationship: RO:0002211 GO:0007020 ! regulates microtubule nucleation created_by: tb creation_date: 2009-05-20T11:51:21Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: RO:0002341 GO:0005874 ! results in transport along microtubule created_by: tb creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031175 ! regulates neuron projection development relationship: RO:0002211 GO:0031175 ! regulates neuron projection development created_by: tb creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031175 ! positively regulates neuron projection development relationship: RO:0002213 GO:0031175 ! positively regulates neuron projection development created_by: tb creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031175 ! negatively regulates neuron projection development relationship: RO:0002212 GO:0031175 ! negatively regulates neuron projection development created_by: tb creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Reactome:R-HSA-5357801 "Programmed Cell Death" xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death intersection_of: GO:0008219 ! cell death intersection_of: starts_with GO:0007165 ! signal transduction relationship: starts_with GO:0007165 ! signal transduction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24835 xsd:anyURI [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical structure relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0031982 ! vesicle relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0014000 name: morula development namespace: biological_process def: "The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: GO:0009790 ! embryo development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000085 ! results in development of morula relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002296 UBERON:0000085 ! results in development of morula property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29162 xsd:anyURI created_by: pg creation_date: 2024-11-12T09:13:07Z [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000125 ! acts on population of glial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0042063 ! gliogenesis relationship: RO:0012003 CL:0000125 ! acts on population of glial cell [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042063 ! regulates gliogenesis relationship: RO:0002211 GO:0042063 ! regulates gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042063 ! negatively regulates gliogenesis relationship: RO:0002212 GO:0042063 ! negatively regulates gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042063 ! positively regulates gliogenesis relationship: RO:0002213 GO:0042063 ! positively regulates gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048699 ! generation of neurons relationship: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0014016 ! neuroblast differentiation relationship: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process alt_id: GO:0014024 def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780] synonym: "neural rod cavitation" RELATED [] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005068 ! results in formation of anatomical entity neural rod relationship: in_taxon NCBITaxon:32443 ! Teleostei relationship: part_of GO:0014020 ! primary neural tube formation relationship: RO:0002297 UBERON:0005068 ! results in formation of anatomical entity neural rod [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007135 ! results in formation of anatomical entity neural keel relationship: in_taxon NCBITaxon:32443 ! Teleostei relationship: part_of GO:0014023 ! neural rod formation relationship: RO:0002297 UBERON:0007135 ! results in formation of anatomical entity neural keel [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002328 ! results in formation of anatomical entity notochord relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0048570 ! notochord morphogenesis relationship: RO:0002297 UBERON:0002328 ! results in formation of anatomical entity notochord [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002342 ! results in formation of anatomical entity neural crest relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0043009 ! chordate embryonic development relationship: RO:0002297 UBERON:0002342 ! results in formation of anatomical entity neural crest [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008019 ! results in development of mesenchymal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048762 ! mesenchymal cell differentiation relationship: RO:0002296 CL:0008019 ! results in development of mesenchymal cell [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048864 ! stem cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0011012 ! results in development of neural crest cell relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0014033 ! neural crest cell differentiation relationship: RO:0002296 CL:0011012 ! results in development of neural crest cell [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042551 ! regulates neuron maturation relationship: RO:0002211 GO:0042551 ! regulates neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042551 ! positively regulates neuron maturation relationship: RO:0002213 GO:0042551 ! positively regulates neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042551 ! negatively regulates neuron maturation relationship: RO:0002212 GO:0042551 ! negatively regulates neuron maturation [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission namespace: biological_process def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion intersection_of: GO:0061526 ! acetylcholine secretion intersection_of: part_of GO:0007271 ! synaptic transmission, cholinergic relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0014056 name: regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission relationship: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission relationship: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission relationship: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048243 ! regulates norepinephrine secretion relationship: RO:0002211 GO:0048243 ! regulates norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001820 ! regulates serotonin secretion relationship: RO:0002211 GO:0001820 ! regulates serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043271 ! negative regulation of monoatomic ion transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion relationship: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043270 ! positive regulation of monoatomic ion transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001820 ! positively regulates serotonin secretion relationship: RO:0002213 GO:0001820 ! positively regulates serotonin secretion [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue relationship: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation relationship: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy relationship: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy relationship: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014896 ! regulates muscle hypertrophy relationship: RO:0002211 GO:0014896 ! regulates muscle hypertrophy [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043500 ! positively regulates muscle adaptation relationship: RO:0002213 GO:0043500 ! positively regulates muscle adaptation [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation relationship: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001756 ! regulates somitogenesis relationship: RO:0002211 GO:0001756 ! regulates somitogenesis [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction relationship: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction [Term] id: GO:0014821 name: phasic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014827 name: intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014831 name: gastro-intestinal system smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981] is_a: GO:0006939 ! smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000737 ! acts on population of striated muscle cell relationship: RO:0012003 CL:0000737 ! acts on population of striated muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle relationship: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation relationship: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation relationship: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation relationship: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: part_of GO:0014819 ! regulation of skeletal muscle contraction relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential relationship: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000056 ! has primary input myoblast relationship: RO:0004009 CL:0000056 ! has primary input myoblast [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation relationship: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014878 name: response to electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation is_a: GO:0051602 ! response to electrical stimulus intersection_of: GO:0051602 ! response to electrical stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014879 name: detection of electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue relationship: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002372 ! results in acquisition of features of myotube relationship: RO:0002315 CL:0002372 ! results in acquisition of features of myotube [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0055002 ! striated muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002372 ! results in development of myotube relationship: part_of GO:0014902 ! myotube differentiation relationship: RO:0002296 CL:0002372 ! results in development of myotube [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0015075 name: monoatomic ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transmembrane transporter activity" BROAD [] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion relationship: part_of GO:0034220 {source="GO_REF:0000090"} ! monoatomic ion transmembrane transport relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24479 xsd:anyURI [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022816 def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] synonym: "sodium transporter activity" EXACT [] is_a: GO:0046873 ! metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29101 ! has primary input sodium(1+) relationship: part_of GO:0035725 ! sodium ion transmembrane transport relationship: RO:0004009 CHEBI:29101 ! has primary input sodium(1+) property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24076 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27521 xsd:anyURI [Term] id: GO:0015101 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" xref: Reactome:R-HSA-9794270 "SLCO1A2 transports Cipro(1+) into the cytosol" xref: Reactome:R-HSA-9794523 "SLC22A1 transports Cipro into renal cell" xref: Reactome:R-HSA-9795207 "SLC22A1 transports Cipro into hepatic cell" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25697 ! has primary input organic cation relationship: part_of GO:0015695 ! organic cation transport relationship: RO:0004009 CHEBI:25697 ! has primary input organic cation [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24834 ! has primary input inorganic anion relationship: part_of GO:0015698 ! inorganic anion transport relationship: RO:0004009 CHEBI:24834 ! has primary input inorganic anion [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] synonym: "hydrogencarbonate transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" is_a: GO:0008514 ! organic anion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:17544 ! has primary input hydrogencarbonate relationship: part_of GO:0015701 ! bicarbonate transport relationship: RO:0004009 CHEBI:17544 ! has primary input hydrogencarbonate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26780 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27521 xsd:anyURI [Term] id: GO:0015116 name: sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] synonym: "sulfate permease activity" RELATED [] synonym: "sulphate transporter activity" EXACT [] xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol" xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16189 ! has primary input sulfate relationship: part_of GO:1902358 {source="GO_REF:0000090"} ! sulfate transmembrane transport relationship: RO:0004009 CHEBI:16189 ! has primary input sulfate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27521 xsd:anyURI [Term] id: GO:0015123 name: acetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate relationship: part_of GO:0035433 {source="GO_REF:0000090"} ! acetate transmembrane transport relationship: RO:0004009 CHEBI:30089 ! has primary input acetate [Term] id: GO:0015125 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" xref: Reactome:R-HSA-9733964 "SLC51A:SLC51B transports bile salts from cytosol to extracellular region" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0170055 ! lipid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:3098 ! has primary input bile acid relationship: part_of GO:0015721 ! bile acid and bile salt transport relationship: RO:0004009 CHEBI:3098 ! has primary input bile acid [Term] id: GO:0015127 name: bilirubin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region" xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:57977 ! has primary input bilirubin(2-) relationship: part_of GO:0015723 ! bilirubin transport relationship: RO:0004009 CHEBI:57977 ! has primary input bilirubin(2-) property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function alt_id: GO:1901476 def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "carbohydrate transporter activity" RELATED [] synonym: "sugar transporter" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: part_of GO:0034219 {source="GO_REF:0000090"} ! carbohydrate transmembrane transport relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0015145 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0051119 ! sugar transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35381 ! has primary input monosaccharide relationship: part_of GO:0015749 ! monosaccharide transmembrane transport relationship: RO:0004009 CHEBI:35381 ! has primary input monosaccharide [Term] id: GO:0015149 name: hexose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18133 ! has primary input hexose relationship: part_of GO:0008645 {source="GO_REF:0000090"} ! hexose transmembrane transport relationship: RO:0004009 CHEBI:18133 ! has primary input hexose [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: part_of GO:0015774 ! polysaccharide transport relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015359 def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol" xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: part_of GO:0003333 {source="GO_REF:0000090"} ! amino acid transmembrane transport relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0015205 name: nucleobase transmembrane transporter activity namespace: molecular_function alt_id: GO:0015392 def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase relationship: part_of GO:0015851 ! nucleobase transport relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase [Term] id: GO:0015318 name: inorganic molecular entity transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] subset: gocheck_do_not_annotate synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] synonym: "inorganic uptake permease activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24835 ! has primary input inorganic molecular entity relationship: RO:0004009 CHEBI:24835 ! has primary input inorganic molecular entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14372 xsd:anyURI [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: Reactome:R-HSA-8981607 "Intracellular oxygen transport" is_a: GO:0015669 ! gas transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15379 ! has primary input dioxygen relationship: RO:0004009 CHEBI:15379 ! has primary input dioxygen [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25697 ! has primary input organic cation relationship: RO:0004009 CHEBI:25697 ! has primary input organic cation [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24834 ! has primary input inorganic anion relationship: RO:0004009 CHEBI:24834 ! has primary input inorganic anion [Term] id: GO:0015701 name: bicarbonate transport namespace: biological_process def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "hydrogencarbonate transport" EXACT [] xref: Reactome:R-HSA-1475029 "Reversible hydration of carbon dioxide" xref: Reactome:R-HSA-1480926 "O2/CO2 exchange in erythrocytes" xref: Reactome:R-HSA-425381 "Bicarbonate transporters" is_a: GO:0015711 ! organic anion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17544 ! has primary input hydrogencarbonate relationship: RO:0004009 CHEBI:17544 ! has primary input hydrogencarbonate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26780 xsd:anyURI [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25696 ! has primary input organic anion relationship: RO:0004009 CHEBI:25696 ! has primary input organic anion [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion [Term] id: GO:0015721 name: bile acid and bile salt transport namespace: biological_process def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] synonym: "bile acid transport" NARROW [] synonym: "bile salt transport" NARROW [] xref: Reactome:R-HSA-159418 "Recycling of bile acids and salts" is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:3098 ! has primary input bile acid relationship: RO:0004009 CHEBI:3098 ! has primary input bile acid [Term] id: GO:0015723 name: bilirubin transport namespace: biological_process def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:57977 ! has primary input bilirubin(2-) relationship: RO:0004009 CHEBI:57977 ! has primary input bilirubin(2-) property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0015749 name: monosaccharide transmembrane transport namespace: biological_process alt_id: GO:1905950 def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] synonym: "monosaccharide transport" RELATED [] is_a: GO:0034219 ! carbohydrate transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:35381 ! has primary input monosaccharide relationship: RO:0004009 CHEBI:35381 ! has primary input monosaccharide created_by: vw creation_date: 2017-02-19T10:41:27Z [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: part_of GO:0033037 ! polysaccharide localization relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0015844 name: monoamine transport namespace: biological_process alt_id: GO:0015873 def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine relationship: RO:0004009 CHEBI:63534 ! has primary input monoamine [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai] synonym: "organic alcohol transport" EXACT [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound relationship: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine relationship: RO:0004009 CHEBI:15355 ! has primary input acetylcholine [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) relationship: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0015932 name: nucleobase-containing compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: part_of GO:0015931 ! nucleobase-containing compound transport relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0016020 name: membrane namespace: cellular_component alt_id: GO:0016021 alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "integral component of membrane" NARROW [] synonym: "integral to membrane" NARROW [] synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane xref: Wikipedia:Transmembrane_protein is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0031012 ! extracellular matrix creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 alt_id: GO:0044240 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0005575 ! results in organization of cellular_component relationship: RO:0002592 GO:0005575 ! results in organization of cellular_component [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000000 ! results in growth of cell relationship: RO:0002343 CL:0000000 ! results in growth of cell [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031982 ! results in organization of vesicle relationship: RO:0002592 GO:0031982 ! results in organization of vesicle [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process alt_id: GO:0006093 def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16646 ! has primary output carbohydrate relationship: RO:0004008 CHEBI:16646 ! has primary output carbohydrate [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process alt_id: GO:0006095 alt_id: GO:0044276 alt_id: GO:0044724 def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate created_by: jl creation_date: 2012-10-23T16:34:39Z [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:64709 ! has primary output organic acid relationship: RO:0004008 CHEBI:64709 ! has primary output organic acid [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential intersection_of: GO:0042391 ! regulation of membrane potential intersection_of: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell relationship: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote synonym: "RNA metabolism" EXACT [] xref: Reactome:R-HSA-8953854 "Metabolism of RNA" is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid relationship: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: RO:0002608 GO:0031982 ! process has causal agent vesicle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25421 xsd:anyURI [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014706 ! regulates striated muscle tissue development relationship: RO:0002211 GO:0014706 ! regulates striated muscle tissue development [Term] id: GO:0016301 name: kinase activity def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0003674 ! molecular_function [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process alt_id: GO:0048130 def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: BFO:0000066 CL:0000023 ! occurs in oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24787 xsd:anyURI property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001525 ! negatively regulates angiogenesis relationship: RO:0002212 GO:0001525 ! negatively regulates angiogenesis [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of CL:0000187 ! muscle cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000187 ! muscle cell [Term] id: GO:0017085 name: response to insecticide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] synonym: "insecticide resistance" RELATED [] synonym: "insecticide susceptibility/resistance" RELATED [] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0005730 ! has primary output nucleolus relationship: RO:0004008 GO:0005730 ! has primary output nucleolus [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell relationship: RO:0004009 CL:0000034 ! has primary input stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process alt_id: GO:0016478 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation relationship: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006887 ! regulates exocytosis relationship: RO:0002211 GO:0006887 ! regulates exocytosis [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output phenols relationship: RO:0004007 CHEBI:33853 ! has primary input or output phenols [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process alt_id: GO:0033057 alt_id: GO:0044704 alt_id: GO:0044705 def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] synonym: "multi-organism reproductive behavior" NARROW [] synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: GO:0048609 ! multicellular organismal reproductive process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23491 xsd:anyURI created_by: jl creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] xref: Reactome:R-HSA-2426168 "Activation of gene expression by SREBF (SREBP)" xref: Reactome:R-HSA-400206 "Regulation of lipid metabolism by PPARalpha" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] xref: Reactome:R-HSA-1989781 "PPARA activates gene expression" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process relationship: RO:0002211 GO:0008152 ! regulates metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] synonym: "conduction of nerve impulse" EXACT [GOC:dph] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0050877 ! nervous system process relationship: has_part GO:0001508 ! action potential relationship: has_part GO:0007268 ! chemical synaptic transmission relationship: part_of GO:0007154 ! cell communication [Term] id: GO:0019228 name: neuronal action potential namespace: biological_process def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system." [GOC:curators] synonym: "nociception" RELATED [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29807 xsd:anyURI [Term] id: GO:0019318 name: hexose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18133 ! has primary input or output hexose relationship: RO:0004007 CHEBI:18133 ! has primary input or output hexose [Term] id: GO:0019319 name: hexose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose anabolism" EXACT [] synonym: "hexose biosynthesis" EXACT [] synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18133 ! has primary output hexose relationship: RO:0004008 CHEBI:18133 ! has primary output hexose [Term] id: GO:0019320 name: hexose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose breakdown" EXACT [] synonym: "hexose catabolism" EXACT [] synonym: "hexose degradation" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18133 ! has primary input hexose relationship: RO:0004009 CHEBI:18133 ! has primary input hexose [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] synonym: "phenol-containing compound breakdown" EXACT [] synonym: "phenol-containing compound catabolism" EXACT [] synonym: "phenol-containing compound degradation" EXACT [] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0009056 ! catabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33853 ! has primary input phenols relationship: RO:0004009 CHEBI:33853 ! has primary input phenols [Term] id: GO:0019413 name: acetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate anabolism" EXACT [] synonym: "acetate biosynthesis" EXACT [] synonym: "acetate formation" EXACT [] synonym: "acetate synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:30089 ! has primary output acetate relationship: RO:0004008 CHEBI:30089 ! has primary output acetate [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044267 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cellular protein metabolic process" EXACT [] synonym: "cellular protein metabolism" EXACT [] synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Reactome:R-HSA-392499 "Metabolism of proteins" xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000000001 ! has primary input or output protein relationship: RO:0004007 PR:000000001 ! has primary input or output protein property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI [Term] id: GO:0019614 name: catechol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol breakdown" RELATED [] synonym: "catechol catabolic process" RELATED [] synonym: "catechol catabolism" RELATED [] synonym: "catechol degradation" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33566 ! has primary input catechols relationship: RO:0004009 CHEBI:33566 ! has primary input catechols [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: BFO:0000066 CL:0000000 ! occurs in cell disjoint_from: GO:0048872 ! homeostasis of number of cells relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] xref: Reactome:R-HSA-389661 "Glyoxylate metabolism and glycine degradation" is_a: GO:0043436 ! oxoacid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion relationship: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound relationship: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0022414 ! reproductive process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22929 xsd:anyURI [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003063 ! results in formation of anatomical entity prechordal plate relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002297 UBERON:0003063 ! results in formation of anatomical entity prechordal plate [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0007417 ! central nervous system development relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord intersection_of: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron relationship: part_of GO:0021517 ! ventral spinal cord development relationship: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021510 ! spinal cord development relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron relationship: part_of GO:0021517 ! ventral spinal cord development relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021522 ! spinal cord motor neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron relationship: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0003002 ! regionalization relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021675 ! nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001785 ! results in development of cranial nerve relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: RO:0002296 UBERON:0001785 ! results in development of cranial nerve [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001892 ! results in development of rhombomere relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development relationship: RO:0002296 UBERON:0001892 ! results in development of rhombomere [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513] synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003052 ! results in formation of anatomical entity midbrain-hindbrain boundary relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development relationship: RO:0002297 UBERON:0003052 ! results in formation of anatomical entity midbrain-hindbrain boundary [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000988 ! results in development of pons relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0022037 ! metencephalon development relationship: RO:0002296 UBERON:0000988 ! results in development of pons [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0030902 ! hindbrain development relationship: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007417 ! central nervous system development relationship: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development relationship: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001017 ! results in formation of anatomical entity central nervous system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0021551 ! central nervous system morphogenesis relationship: RO:0002297 UBERON:0001017 ! results in formation of anatomical entity central nervous system [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "rhombencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development relationship: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002028 ! results in formation of anatomical entity hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021575 ! hindbrain morphogenesis relationship: RO:0002297 UBERON:0002028 ! results in formation of anatomical entity hindbrain [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021626 ! central nervous system maturation relationship: part_of GO:0030902 ! hindbrain development relationship: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021575 ! hindbrain morphogenesis relationship: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001896 ! results in formation of anatomical entity medulla oblongata relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021579 ! medulla oblongata morphogenesis relationship: RO:0002297 UBERON:0001896 ! results in formation of anatomical entity medulla oblongata [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021578 ! hindbrain maturation relationship: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021575 ! hindbrain morphogenesis relationship: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000988 ! results in formation of anatomical entity pons relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021583 ! pons morphogenesis relationship: RO:0002297 UBERON:0000988 ! results in formation of anatomical entity pons [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000988 ! results in maturation of pons relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021578 ! hindbrain maturation relationship: RO:0002299 UBERON:0000988 ! results in maturation of pons [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021546 ! rhombomere development relationship: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001892 ! results in formation of anatomical entity rhombomere relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021593 ! rhombomere morphogenesis relationship: RO:0002297 UBERON:0001892 ! results in formation of anatomical entity rhombomere [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021545 ! cranial nerve development relationship: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001785 ! results in formation of anatomical entity cranial nerve relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021602 ! cranial nerve morphogenesis relationship: RO:0002297 UBERON:0001785 ! results in formation of anatomical entity cranial nerve [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021682 ! nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021545 ! cranial nerve development relationship: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007417 ! central nervous system development relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021559 ! trigeminal nerve development relationship: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021559 ! trigeminal nerve development relationship: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001645 ! results in formation of anatomical entity trigeminal nerve relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis relationship: RO:0002297 UBERON:0001645 ! results in formation of anatomical entity trigeminal nerve [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0018239 ! results in formation of anatomical entity rhombomere boundary relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021594 ! rhombomere formation relationship: RO:0002297 UBERON:0018239 ! results in formation of anatomical entity rhombomere boundary [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001021 ! results in development of nerve relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002296 UBERON:0001021 ! results in development of nerve [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001021 ! results in maturation of nerve relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0021675 ! nerve development relationship: RO:0002299 UBERON:0001021 ! results in maturation of nerve [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] subset: goslim_chembl is_a: GO:0032502 ! developmental process [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021548 ! pons development relationship: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021703 ! locus ceruleus development relationship: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002148 ! results in formation of anatomical entity locus ceruleus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021704 ! locus ceruleus morphogenesis relationship: RO:0002297 UBERON:0002148 ! results in formation of anatomical entity locus ceruleus [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021703 ! locus ceruleus development relationship: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021548 ! pons development relationship: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021718 ! superior olivary nucleus development relationship: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007247 ! results in formation of anatomical entity nucleus of superior olivary complex relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis relationship: RO:0002297 UBERON:0007247 ! results in formation of anatomical entity nucleus of superior olivary complex [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021718 ! superior olivary nucleus development relationship: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development relationship: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021548 ! pons development relationship: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021751 ! salivary nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus relationship: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000125 ! results in development of glial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0010001 ! glial cell differentiation relationship: RO:0002296 CL:0000125 ! results in development of glial cell [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005076 ! results in formation of anatomical entity hindbrain-spinal cord boundary relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning relationship: RO:0002297 UBERON:0005076 ! results in formation of anatomical entity hindbrain-spinal cord boundary [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001049 ! results in development of neural tube relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0043009 ! chordate embryonic development relationship: RO:0002296 UBERON:0001049 ! results in development of neural tube [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007417 ! central nervous system development relationship: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000029 ! results in development of central nervous system neuron relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0021953 ! central nervous system neuron differentiation relationship: RO:0002296 CL:2000029 ! results in development of central nervous system neuron [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003075 ! results in formation of anatomical entity neural plate relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0001839 ! neural plate morphogenesis relationship: RO:0002297 UBERON:0003075 ! results in formation of anatomical entity neural plate [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0060897 ! neural plate regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21480 xsd:anyURI [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700] is_a: GO:0021535 ! cell migration in hindbrain intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere relationship: part_of GO:0021546 ! rhombomere development relationship: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001895 ! results in development of metencephalon relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030902 ! hindbrain development relationship: RO:0002296 UBERON:0001895 ! results in development of metencephalon [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002590 GO:0005575 ! results in disassembly of cellular_component disjoint_from: GO:0022607 ! cellular component assembly relationship: RO:0002590 GO:0005575 ! results in disassembly of cellular_component property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "single organism reproductive process" RELATED [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27054 xsd:anyURI created_by: jl creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] subset: goslim_generic is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: part_of GO:0007586 ! digestion relationship: part_of GO:0007586 ! digestion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis relationship: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000902 ! regulates cell morphogenesis relationship: RO:0002211 GO:0000902 ! regulates cell morphogenesis [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0005575 ! results in assembly of cellular_component relationship: part_of GO:0044085 ! cellular component biogenesis relationship: RO:0002588 GO:0005575 ! results in assembly of cellular_component [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland relationship: part_of GO:0048732 ! gland development relationship: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] xref: Reactome:R-HSA-1474228 "Degradation of the extracellular matrix" is_a: GO:0022411 ! cellular component disassembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix relationship: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix [Term] id: GO:0022618 name: protein-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl synonym: "ribonucleoprotein complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis relationship: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: part_of GO:0055085 ! transmembrane transport relationship: RO:0002342 GO:0016020 ! results in transport across membrane [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule [Term] id: GO:0022890 name: inorganic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015077 alt_id: GO:0015082 alt_id: GO:0072509 alt_id: GO:0072510 def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] synonym: "divalent inorganic cation transmembrane transporter activity" NARROW [] synonym: "monovalent inorganic cation transmembrane transporter activity" NARROW [] synonym: "trivalent inorganic cation transmembrane transporter activity" NARROW [] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:36915 ! has primary input inorganic cation relationship: RO:0004009 CHEBI:36915 ! has primary input inorganic cation [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] subset: gocheck_obsoletion_candidate is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity relationship: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0010468 ! regulation of gene expression relationship: part_of GO:0010468 ! regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0023052 ! regulates signaling relationship: RO:0002211 GO:0023052 ! regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0050789 ! regulation of biological process created_by: jl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0023052 ! positively regulates signaling relationship: RO:0002213 GO:0023052 ! positively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0023052 ! negatively regulates signaling relationship: RO:0002212 GO:0023052 ! negatively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: GO:0032940 ! secretion by cell intersection_of: GO:0032940 ! secretion by cell intersection_of: part_of GO:0007267 ! cell-cell signaling relationship: part_of GO:0007267 ! cell-cell signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030001 name: metal ion transport namespace: biological_process alt_id: GO:0070838 alt_id: GO:0070839 def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "divalent metal ion export" NARROW [] synonym: "divalent metal ion transport" NARROW [] synonym: "heavy metal ion transport" NARROW [] synonym: "metal ion export" NARROW [] is_a: GO:0006812 ! monoatomic cation transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25213 ! has primary input metal cation relationship: RO:0004009 CHEBI:25213 ! has primary input metal cation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23033 xsd:anyURI created_by: mah creation_date: 2009-07-31T01:07:46Z [Term] id: GO:0030003 name: intracellular monoatomic cation homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah] synonym: "cellular cation homeostasis" BROAD [] synonym: "cellular monoatomic cation homeostasis" EXACT [] is_a: GO:0006873 ! intracellular monoatomic ion homeostasis is_a: GO:0055080 ! monoatomic cation homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:23906 ! regulates levels of monoatomic cation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24455 xsd:anyURI [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process alt_id: GO:0000283 alt_id: GO:0030468 def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: part_of CL:0000737 ! striated muscle cell relationship: part_of CL:0000737 ! striated muscle cell [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005884 ! process has causal agent actin filament relationship: RO:0002608 GO:0005884 ! process has causal agent actin filament [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] subset: goslim_prokaryote synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042995 ! results in organization of cell projection relationship: RO:0002592 GO:0042995 ! results in organization of cell projection property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26279 xsd:anyURI [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042995 ! results in assembly of cell projection relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002588 GO:0042995 ! results in assembly of cell projection [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005902 ! results in assembly of microvillus relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002588 GO:0005902 ! results in assembly of microvillus [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton relationship: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23114 xsd:anyURI [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0030029 ! actin filament-based process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon xref: Wikipedia:Cell_junction is_a: GO:0110165 ! cellular anatomical structure property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:25905 ! has primary input peptide hormone relationship: RO:0004009 CHEBI:25905 ! has primary input peptide hormone [Term] id: GO:0030073 name: insulin secretion namespace: biological_process def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000009054 ! has primary input insulin gene translation product relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0004009 PR:000009054 ! has primary input insulin gene translation product property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/11255 xsd:anyURI [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000988 ! results in development of hematopoietic cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 CL:0000988 ! results in development of hematopoietic cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22178 xsd:anyURI [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030097 ! hemopoiesis relationship: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: part_of GO:0012505 ! endomembrane system property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0048869 ! cellular developmental process intersection_of: RO:0002315 CL:0000000 ! results in acquisition of features of cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002315 CL:0000000 ! results in acquisition of features of cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24390 xsd:anyURI [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process alt_id: GO:0044254 alt_id: GO:0044257 def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_candida subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolic process" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000540 ! results in acquisition of features of neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048699 ! generation of neurons relationship: RO:0002315 CL:0000540 ! results in acquisition of features of neuron [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] xref: Reactome:R-HSA-1474244 "Extracellular matrix organization" is_a: GO:0043062 ! extracellular structure organization is_a: GO:0045229 ! external encapsulating structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031012 ! results in organization of extracellular matrix relationship: RO:0002592 GO:0031012 ! results in organization of extracellular matrix [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [] synonym: "fibrillar collagen organization" EXACT [GOC:mah] xref: Reactome:R-HSA-1474290 "Collagen formation" xref: Reactome:R-HSA-2214320 "Anchoring fibril formation" xref: Reactome:R-HSA-2243919 "Crosslinking of collagen fibrils" is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098643 ! results in organization of banded collagen fibril relationship: RO:0002592 GO:0098643 ! results in organization of banded collagen fibril property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan metabolism" EXACT [] xref: Reactome:R-HSA-1630316 "Glycosaminoglycan metabolism" is_a: GO:0006022 ! aminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18085 ! has primary input or output glycosaminoglycan relationship: RO:0004007 CHEBI:18085 ! has primary input or output glycosaminoglycan property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29745 xsd:anyURI [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan metabolism" EXACT [] xref: Reactome:R-HSA-2142845 "Hyaluronan metabolism" is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16336 ! has primary input or output hyaluronic acid relationship: RO:0004007 CHEBI:16336 ! has primary input or output hyaluronic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29745 xsd:anyURI [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] xref: Reactome:R-HSA-2142850 "Hyaluronan biosynthesis and export" is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16336 ! has primary output hyaluronic acid relationship: RO:0004008 CHEBI:16336 ! has primary output hyaluronic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29745 xsd:anyURI [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] xref: MetaCyc:PWY-7645 xref: Reactome:R-HSA-2160916 "Hyaluronan uptake and degradation" is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16336 ! has primary input hyaluronic acid relationship: RO:0004009 CHEBI:16336 ! has primary input hyaluronic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27107 xsd:anyURI [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte relationship: part_of GO:0034101 ! erythrocyte homeostasis relationship: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte relationship: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0097435 ! supramolecular fiber organization is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030016 ! results in assembly of myofibril relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0055002 ! striated muscle cell development relationship: RO:0002588 GO:0030016 ! results in assembly of myofibril [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: part_of GO:0030262 ! apoptotic nuclear changes property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: part_of GO:0030262 ! apoptotic nuclear changes relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: part_of GO:0030262 ! apoptotic nuclear changes property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001503 ! regulates ossification relationship: RO:0002211 GO:0001503 ! regulates ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001503 ! negatively regulates ossification relationship: RO:0002212 GO:0001503 ! negatively regulates ossification [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016049 ! positively regulates cell growth relationship: RO:0002213 GO:0016049 ! positively regulates cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016049 ! negatively regulates cell growth relationship: RO:0002212 GO:0016049 ! negatively regulates cell growth [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000117 ! results in development of respiratory tube relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0000117 ! results in development of respiratory tube [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002048 ! results in development of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030323 ! respiratory tube development relationship: part_of GO:0060541 ! respiratory system development relationship: RO:0002296 UBERON:0002048 ! results in development of lung [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016477 ! regulates cell migration relationship: RO:0002211 GO:0016477 ! regulates cell migration property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016477 ! positively regulates cell migration relationship: RO:0002213 GO:0016477 ! positively regulates cell migration property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016477 ! negatively regulates cell migration relationship: RO:0002212 GO:0016477 ! negatively regulates cell migration property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0016020 ! results in disassembly of membrane relationship: RO:0002590 GO:0016020 ! results in disassembly of membrane [Term] id: GO:0030421 name: defecation namespace: biological_process def: "The expulsion of feces from the rectum." [GOC:mah] xref: Wikipedia:Defecation is_a: GO:0007588 ! excretion is_a: GO:0022600 ! digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030432 name: peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732] xref: Wikipedia:Peristalsis is_a: GO:0014821 ! phasic smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process alt_id: GO:0000065 def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton relationship: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: part_of CL:0000192 ! smooth muscle cell relationship: part_of CL:0000192 ! smooth muscle cell [Term] id: GO:0030573 name: bile acid catabolic process namespace: biological_process alt_id: GO:0019613 def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] synonym: "bile acid breakdown" EXACT [] synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:36235 ! has primary input bile acid anion relationship: RO:0004009 CHEBI:36235 ! has primary input bile acid anion [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] xref: Reactome:R-HSA-1442490 "Collagen degradation" is_a: GO:0009056 ! catabolic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer [Term] id: GO:0030642 name: intracellular sulfate ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of sulfate ions within a cell." [GOC:mah, PMID:24193406] synonym: "cellular sulfate ion homeostasis" EXACT [] synonym: "sulphate ion homeostasis" BROAD [] is_a: GO:0055063 ! sulfate ion homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:16189 ! regulates levels of sulfate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24514 xsd:anyURI [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0030133 ! transport vesicle relationship: bounding_layer_of GO:0030133 ! transport vesicle relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0031410 ! cytoplasmic vesicle relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005798 ! Golgi-associated vesicle relationship: bounding_layer_of GO:0005798 ! Golgi-associated vesicle relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0030141 ! secretory granule relationship: bounding_layer_of GO:0030141 ! secretory granule relationship: part_of GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber relationship: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0051674 ! localization of cell intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000023 ! has primary input oocyte relationship: in_taxon NCBITaxon:50557 ! Insecta relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: RO:0004009 CL:0000023 ! has primary input oocyte [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0060429 ! epithelium development relationship: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation relationship: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation relationship: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation relationship: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001891 ! results in development of midbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0007420 ! brain development relationship: RO:0002296 UBERON:0001891 ! results in development of midbrain [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [PMID:4975589, PMID:4992177] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002028 ! results in development of hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0007420 ! brain development relationship: RO:0002296 UBERON:0002028 ! results in development of hindbrain [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002328 ! results in development of notochord relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: RO:0002296 UBERON:0002328 ! results in development of notochord [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning relationship: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary [Term] id: GO:0030936 name: transmembrane collagen trimer namespace: cellular_component def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: capable_of_part_of GO:0035735 ! intraciliary transport involved in cilium assembly [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, PMID:21123617, PMID:28089324, PMID:33605520] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0030312 ! external encapsulating structure disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001264 ! results in development of pancreas relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0001264 ! results in development of pancreas property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23777 xsd:anyURI [Term] id: GO:0031017 name: exocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000017 ! results in development of exocrine pancreas relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035272 ! exocrine system development relationship: part_of GO:0055123 ! digestive system development relationship: RO:0002296 UBERON:0000017 ! results in development of exocrine pancreas [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] xref: Reactome:R-HSA-186712 "Regulation of beta-cell development" is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000016 ! results in development of endocrine pancreas relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035270 ! endocrine system development relationship: RO:0002296 UBERON:0000016 ! results in development of endocrine pancreas [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042641 ! results in organization of actomyosin relationship: RO:0002592 GO:0042641 ! results in organization of actomyosin [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] synonym: "microtubule dynamics" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23195 xsd:anyURI [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization relationship: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization relationship: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization relationship: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046785 ! regulates microtubule polymerization relationship: RO:0002211 GO:0046785 ! regulates microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007019 ! regulates microtubule depolymerization relationship: RO:0002211 GO:0007019 ! regulates microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization relationship: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization relationship: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization relationship: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule relationship: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: in_taxon NCBITaxon:131567 ! cellular organisms property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: part_of GO:0048666 ! neuron development relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0120025 ! plasma membrane bounded cell projection relationship: bounding_layer_of GO:0120025 ! plasma membrane bounded cell projection relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0031252 ! cell leading edge property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly relationship: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly relationship: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006906 ! regulates vesicle fusion relationship: RO:0002211 GO:0006906 ! regulates vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion relationship: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006906 ! positively regulates vesicle fusion relationship: RO:0002213 GO:0006906 ! positively regulates vesicle fusion [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030030 ! regulates cell projection organization relationship: RO:0002211 GO:0030030 ! regulates cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030030 ! negatively regulates cell projection organization relationship: RO:0002212 GO:0030030 ! negatively regulates cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030030 ! positively regulates cell projection organization relationship: RO:0002213 GO:0030030 ! positively regulates cell projection organization [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process alt_id: GO:0034629 def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "cellular protein complex localisation" RELATED [GOC:mah] synonym: "cellular protein complex localization" RELATED [] synonym: "cellular protein-containing complex localization" RELATED [] synonym: "establishment and maintenance of cellular protein complex localization" RELATED [] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22021 xsd:anyURI [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] synonym: "NMJ" RELATED [GOC:ha] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: overlaps CL:0000100 ! motor neuron intersection_of: overlaps CL:0000187 ! muscle cell relationship: overlaps CL:0000100 ! motor neuron relationship: overlaps CL:0000187 ! muscle cell [Term] id: GO:0031644 name: regulation of nervous system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurological system process" EXACT [] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050877 ! regulates nervous system process relationship: RO:0002211 GO:0050877 ! regulates nervous system process [Term] id: GO:0031645 name: negative regulation of nervous system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurological system process" EXACT [] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050877 ! negatively regulates nervous system process relationship: RO:0002212 GO:0050877 ! negatively regulates nervous system process [Term] id: GO:0031646 name: positive regulation of nervous system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurological system process" EXACT [] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050877 ! positively regulates nervous system process relationship: RO:0002213 GO:0050877 ! positively regulates nervous system process [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005634 ! nucleus relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0043226 ! organelle intersection_of: part_of GO:0031967 ! organelle envelope relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0045202 ! synapse [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0070013 ! intracellular organelle lumen relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion intersection_of: GO:0040011 ! locomotion intersection_of: part_of GO:0007626 ! locomotory behavior relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0032024 name: positive regulation of insulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] synonym: "activation of insulin secretion" NARROW [] synonym: "stimulation of insulin secretion" NARROW [] synonym: "up regulation of insulin secretion" EXACT [] synonym: "up-regulation of insulin secretion" EXACT [] synonym: "upregulation of insulin secretion" EXACT [] xref: Reactome:R-HSA-399997 "Acetylcholine regulates insulin secretion" is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030073 ! positively regulates insulin secretion relationship: RO:0002213 GO:0030073 ! positively regulates insulin secretion [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0045947 ! negative regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0006950 ! response to stress intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: part_of GO:0006950 ! response to stress [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0045948 ! positive regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0006950 ! response to stress intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: part_of GO:0006950 ! response to stress [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] subset: goslim_pir synonym: "plasma membrane bleb" EXACT [GOC:pr] xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032059 ! results in assembly of bleb relationship: RO:0002588 GO:0032059 ! results in assembly of bleb [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009605 ! regulates response to external stimulus relationship: RO:0002211 GO:0009605 ! regulates response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus relationship: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009605 ! positively regulates response to external stimulus relationship: RO:0002213 GO:0009605 ! positively regulates response to external stimulus [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0031045 ! dense core granule relationship: bounding_layer_of GO:0031045 ! dense core granule relationship: part_of GO:0031045 ! dense core granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic relationship: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic relationship: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic relationship: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110053 ! regulation of actin filament organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly relationship: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly relationship: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly relationship: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport relationship: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport relationship: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport relationship: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0030141 ! has primary input secretory granule relationship: RO:0004009 GO:0030141 ! has primary input secretory granule [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule relationship: RO:0004009 GO:0031045 ! has primary input dense core granule [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051258 ! regulates protein polymerization relationship: RO:0002211 GO:0051258 ! regulates protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051258 ! negatively regulates protein polymerization relationship: RO:0002212 GO:0051258 ! negatively regulates protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051258 ! positively regulates protein polymerization relationship: RO:0002213 GO:0051258 ! positively regulates protein polymerization [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation relationship: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061037 ! negative regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation relationship: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0061036 ! positive regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation relationship: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation [Term] id: GO:0032364 name: intracellular oxygen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell." [GOC:rph] synonym: "cellular oxygen homeostasis" EXACT [] synonym: "oxygen homeostasis" BROAD [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:15379 ! regulates levels of dioxygen relationship: RO:0002332 CHEBI:15379 ! regulates levels of dioxygen property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24224 xsd:anyURI [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006869 ! regulates lipid transport relationship: RO:0002211 GO:0006869 ! regulates lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006869 ! negatively regulates lipid transport relationship: RO:0002212 GO:0006869 ! negatively regulates lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006869 ! positively regulates lipid transport relationship: RO:0002213 GO:0006869 ! positively regulates lipid transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032365 ! regulates intracellular lipid transport relationship: RO:0002211 GO:0032365 ! regulates intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport relationship: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport relationship: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046907 ! regulates intracellular transport relationship: RO:0002211 GO:0046907 ! regulates intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046907 ! negatively regulates intracellular transport relationship: RO:0002212 GO:0046907 ! negatively regulates intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046907 ! positively regulates intracellular transport relationship: RO:0002213 GO:0046907 ! positively regulates intracellular transport [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005215 ! regulates transporter activity relationship: RO:0002211 GO:0005215 ! regulates transporter activity [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005215 ! negatively regulates transporter activity relationship: RO:0002212 GO:0005215 ! negatively regulates transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005215 ! positively regulates transporter activity relationship: RO:0002213 GO:0005215 ! positively regulates transporter activity [Term] id: GO:0032412 name: regulation of monoatomic ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "regulation of ion transmembrane transporter activity" BROAD [] synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015075 ! regulates monoatomic ion transmembrane transporter activity relationship: RO:0002211 GO:0015075 ! regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component alt_id: GO:0000141 alt_id: GO:0030482 def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: has_part GO:0005884 ! actin filament relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0044707 alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: jl creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organisation" EXACT [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005902 ! results in organization of microvillus relationship: RO:0002592 GO:0005902 ! results in organization of microvillus property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organisation" EXACT [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032528 ! regulates microvillus organization relationship: RO:0002211 GO:0032528 ! regulates microvillus organization [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030033 ! regulates microvillus assembly relationship: RO:0002211 GO:0030033 ! regulates microvillus assembly [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0043005 ! neuron projection relationship: bounding_layer_of GO:0043005 ! neuron projection relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane relationship: BFO:0000066 GO:0016020 ! occurs in membrane [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process alt_id: GO:0062103 def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. subset: gocheck_do_not_annotate synonym: "double-stranded RNA biosynthesis" NARROW [] synonym: "double-stranded RNA biosynthetic process" NARROW [] synonym: "dsRNA biosynthesis" NARROW [] synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141187 ! nucleic acid biosynthetic process intersection_of: GO:0009059 ! macromolecule biosynthetic process intersection_of: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid relationship: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid [Term] id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046717 ! acid secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:36235 ! has primary input bile acid anion relationship: RO:0004009 CHEBI:36235 ! has primary input bile acid anion [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion relationship: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005840 ! results in disassembly of ribosome relationship: RO:0002590 GO:0005840 ! results in disassembly of ribosome [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032868 name: response to insulin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] synonym: "response to insulin stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0042221 ! response to chemical intersection_of: RO:0004009 PR:000009054 ! has primary input insulin gene translation product relationship: RO:0004009 PR:000009054 ! has primary input insulin gene translation product property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] is_a: GO:0032868 ! response to insulin is_a: GO:0071375 ! cellular response to peptide hormone stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 PR:000009054 ! has primary input insulin gene translation product property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000741 ! regulates karyogamy relationship: RO:0002211 GO:0000741 ! regulates karyogamy [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity relationship: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] subset: gocheck_do_not_annotate synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051179 ! regulates localization relationship: RO:0002211 GO:0051179 ! regulates localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process alt_id: GO:1903827 def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008104 ! regulates protein localization relationship: RO:0002211 GO:0008104 ! regulates protein localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22021 xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process relationship: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process relationship: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007017 ! regulates microtubule-based process relationship: RO:0002211 GO:0007017 ! regulates microtubule-based process [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015849 ! regulates organic acid transport relationship: RO:0002211 GO:0015849 ! regulates organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015849 ! negatively regulates organic acid transport relationship: RO:0002212 GO:0015849 ! negatively regulates organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015849 ! positively regulates organic acid transport relationship: RO:0002213 GO:0015849 ! positively regulates organic acid transport [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization relationship: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 GO:0005581 ! has primary input or output collagen trimer relationship: RO:0004007 GO:0005581 ! has primary input or output collagen trimer [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 GO:0005581 ! has primary output collagen trimer relationship: RO:0004008 GO:0005581 ! has primary output collagen trimer [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process relationship: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process relationship: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process relationship: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030029 ! regulates actin filament-based process relationship: RO:0002211 GO:0030029 ! regulates actin filament-based process [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process alt_id: GO:0034623 alt_id: GO:0043241 alt_id: GO:0043624 def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "cellular protein complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex relationship: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22580 xsd:anyURI [Term] id: GO:0032988 name: protein-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "ribonucleoprotein complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex relationship: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25143 xsd:anyURI [Term] id: GO:0032989 name: cellular anatomical entity morphogenesis namespace: biological_process def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular component morphogenesis" EXACT [] synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25496 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26249 xsd:anyURI [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component disjoint_from: GO:0110165 ! cellular anatomical structure relationship: has_part PR:000000001 ! protein [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000187 ! acts on population of muscle cell relationship: RO:0012003 CL:0000187 ! acts on population of muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] subset: goslim_pombe subset: goslim_prokaryote synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26932 ! has primary input or output tetrapyrrole relationship: RO:0004007 CHEBI:26932 ! has primary input or output tetrapyrrole [Term] id: GO:0033014 name: tetrapyrrole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole anabolism" EXACT [] synonym: "tetrapyrrole biosynthesis" EXACT [] synonym: "tetrapyrrole formation" EXACT [] synonym: "tetrapyrrole synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0033013 ! tetrapyrrole metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26932 ! has primary output tetrapyrrole relationship: RO:0004008 CHEBI:26932 ! has primary output tetrapyrrole [Term] id: GO:0033015 name: tetrapyrrole catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole breakdown" EXACT [] synonym: "tetrapyrrole catabolism" EXACT [] synonym: "tetrapyrrole degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26932 ! has primary input tetrapyrrole relationship: RO:0004009 CHEBI:26932 ! has primary input tetrapyrrole [Term] id: GO:0033028 name: myeloid cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] synonym: "myeloid cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000763 ! occurs in myeloid cell relationship: BFO:0000066 CL:0000763 ! occurs in myeloid cell property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033032 name: regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process relationship: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] synonym: "negative regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process relationship: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "positive regulation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process relationship: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006996 ! regulates organelle organization relationship: RO:0002211 GO:0006996 ! regulates organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051276 ! regulates chromosome organization relationship: RO:0002211 GO:0051276 ! regulates chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000819 ! regulates sister chromatid segregation relationship: RO:0002211 GO:0000819 ! regulates sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation relationship: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation relationship: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation relationship: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006886 ! regulates intracellular protein transport relationship: RO:0002211 GO:0006886 ! regulates intracellular protein transport [Term] id: GO:0033238 name: regulation of amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] synonym: "regulation of amine metabolism" EXACT [] synonym: "regulation of cellular amine metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009308 ! regulates amine metabolic process relationship: RO:0002211 GO:0009308 ! regulates amine metabolic process [Term] id: GO:0033239 name: negative regulation of amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] synonym: "negative regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process relationship: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process [Term] id: GO:0033240 name: positive regulation of amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] synonym: "positive regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009308 ! positively regulates amine metabolic process relationship: RO:0002213 GO:0009308 ! positively regulates amine metabolic process [Term] id: GO:0033241 name: regulation of amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] synonym: "regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009310 ! regulates amine catabolic process relationship: RO:0002211 GO:0009310 ! regulates amine catabolic process [Term] id: GO:0033242 name: negative regulation of amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] synonym: "negative regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process relationship: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process [Term] id: GO:0033243 name: positive regulation of amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009310 ! positively regulates amine catabolic process relationship: RO:0002213 GO:0009310 ! positively regulates amine catabolic process [Term] id: GO:0033278 name: cell proliferation in midbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] synonym: "cell proliferation in mesencephalon" EXACT [] synonym: "mesencepahalic cell proliferation" RELATED [] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0001891 ! occurs in midbrain relationship: BFO:0000066 UBERON:0001891 ! occurs in midbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organisation" EXACT [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: part_of GO:0010256 ! endomembrane system organization relationship: RO:0002592 GO:0030141 ! results in organization of secretory granule [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle relationship: RO:0002339 GO:0043226 ! has target end location organelle [Term] id: GO:0033366 name: protein localization to secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] synonym: "protein localisation in secretory granule" EXACT [GOC:mah] synonym: "protein localization in secretory granule" EXACT [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:16646 ! regulates levels of carbohydrate relationship: RO:0002332 CHEBI:16646 ! regulates levels of carbohydrate [Term] id: GO:0033604 name: negative regulation of catecholamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "down regulation of catecholamine secretion" EXACT [] synonym: "down-regulation of catecholamine secretion" EXACT [] synonym: "downregulation of catecholamine secretion" EXACT [] synonym: "inhibition of catecholamine secretion" NARROW [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion relationship: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion [Term] id: GO:0033605 name: positive regulation of catecholamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "activation of catecholamine secretion" NARROW [] synonym: "stimulation of catecholamine secretion" NARROW [] synonym: "up regulation of catecholamine secretion" EXACT [] synonym: "up-regulation of catecholamine secretion" EXACT [] synonym: "upregulation of catecholamine secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion relationship: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion [Term] id: GO:0033750 name: ribosome localization namespace: biological_process alt_id: GO:0033753 def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "establishment of ribosome localisation" RELATED [] synonym: "establishment of ribosome localization" RELATED [] synonym: "ribosome localisation" RELATED [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome relationship: RO:0004009 GO:0005840 ! has primary input ribosome [Term] id: GO:0033762 name: response to glucagon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] synonym: "response to glucagon stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:5391 ! has primary input glucagon relationship: RO:0004009 CHEBI:5391 ! has primary input glucagon property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0034067 name: protein localization to Golgi apparatus namespace: biological_process alt_id: GO:0000042 alt_id: GO:0072600 def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah] synonym: "establishment of protein localization in Golgi" NARROW [] synonym: "establishment of protein localization to Golgi" NARROW [] synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization in Golgi apparatus" EXACT [] synonym: "protein targeting to Golgi" RELATED [] synonym: "protein-Golgi targeting" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus created_by: mah creation_date: 2011-02-14T02:26:36Z [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000232 ! acts on population of erythrocyte relationship: RO:0012003 CL:0000232 ! acts on population of erythrocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0034220 name: monoatomic ion transmembrane transport namespace: biological_process alt_id: GO:0099131 def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] synonym: "ion membrane transport" EXACT [] synonym: "ion transmembrane transport" BROAD [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-983712 "Ion channel transport" is_a: GO:0006811 ! monoatomic ion transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion [Term] id: GO:0034242 name: negative regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion relationship: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0034248 name: regulation of amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] synonym: "regulation of cellular amide metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043603 ! regulates amide metabolic process relationship: RO:0002211 GO:0043603 ! regulates amide metabolic process [Term] id: GO:0034249 name: negative regulation of amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] synonym: "negative regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process relationship: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process [Term] id: GO:0034250 name: positive regulation of amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] synonym: "positive regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043603 ! positively regulates amide metabolic process relationship: RO:0002213 GO:0043603 ! positively regulates amide metabolic process [Term] id: GO:0034251 name: regulation of amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] synonym: "regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043605 ! regulates amide catabolic process relationship: RO:0002211 GO:0043605 ! regulates amide catabolic process [Term] id: GO:0034252 name: negative regulation of amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] synonym: "negative regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process relationship: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process [Term] id: GO:0034253 name: positive regulation of amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] synonym: "positive regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043605 ! positively regulates amide catabolic process relationship: RO:0002213 GO:0043605 ! positively regulates amide catabolic process [Term] id: GO:0034284 name: response to monosaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:35381 ! has primary input monosaccharide relationship: RO:0004009 CHEBI:35381 ! has primary input monosaccharide [Term] id: GO:0034329 name: cell junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] xref: Reactome:R-HSA-446728 "Cell junction organization" is_a: GO:0022607 ! cellular component assembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030054 ! results in assembly of cell junction relationship: RO:0002588 GO:0030054 ! results in assembly of cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030054 ! results in organization of cell junction relationship: RO:0002592 GO:0030054 ! results in organization of cell junction [Term] id: GO:0034349 name: glial cell apoptotic process namespace: biological_process def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] synonym: "apoptosis of glia" EXACT [] synonym: "apoptosis of glial cells" EXACT [] synonym: "glia apoptosis" EXACT [] synonym: "glia programmed cell death by apoptosis" EXACT [] synonym: "glial cell apoptosis" NARROW [] synonym: "glial cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of glia by apoptosis" EXACT [] synonym: "programmed cell death of glial cells by apoptosis" EXACT [] synonym: "programmed cell death, glia" EXACT [] synonym: "programmed cell death, glial cells" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000125 ! occurs in glial cell relationship: BFO:0000066 CL:0000125 ! occurs in glial cell property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034350 name: regulation of glial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of glial cell apoptosis" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process relationship: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034351 name: negative regulation of glial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "down regulation of glial cell apoptosis" EXACT [] synonym: "down-regulation of glial cell apoptosis" EXACT [] synonym: "downregulation of glial cell apoptosis" EXACT [] synonym: "inhibition of glial cell apoptosis" NARROW [] synonym: "negative regulation of glial cell apoptosis" NARROW [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process relationship: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034352 name: positive regulation of glial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "activation of glial cell apoptosis" NARROW [] synonym: "positive regulation of glial cell apoptosis" NARROW [] synonym: "stimulation of glial cell apoptosis" NARROW [] synonym: "up regulation of glial cell apoptosis" EXACT [] synonym: "up-regulation of glial cell apoptosis" EXACT [] synonym: "upregulation of glial cell apoptosis" EXACT [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process relationship: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034390 name: smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptosis of smooth muscle cells" EXACT [] synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] synonym: "programmed cell death, smooth muscle cells" EXACT [] synonym: "SMC apoptosis" EXACT [] synonym: "smooth muscle cell apoptosis" NARROW [] synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell relationship: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell [Term] id: GO:0034391 name: regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "regulation of SMC apoptosis" EXACT [] synonym: "regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process relationship: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034392 name: negative regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] synonym: "negative regulation of SMC apoptosis" EXACT [] synonym: "negative regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process relationship: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034393 name: positive regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "activation of smooth muscle cell apoptosis" NARROW [] synonym: "positive regulation of SMC apoptosis" EXACT [] synonym: "positive regulation of smooth muscle cell apoptosis" NARROW [] synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process relationship: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034436 name: glycoprotein transport namespace: biological_process def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0015031 ! protein transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17089 ! has primary input glycoprotein relationship: RO:0004009 CHEBI:17089 ! has primary input glycoprotein [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0034487 name: vacuolar amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar amino acid membrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome relationship: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process alt_id: GO:0044744 def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] synonym: "protein targeting to nucleus" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity relationship: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "regulation of membrane transport" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055085 ! regulates transmembrane transport relationship: RO:0002211 GO:0055085 ! regulates transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] synonym: "negative regulation of membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport relationship: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "positive regulation of membrane transport" EXACT [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055085 ! positively regulates transmembrane transport relationship: RO:0002213 GO:0055085 ! positively regulates transmembrane transport [Term] id: GO:0034765 name: regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of ion membrane transport" EXACT [] synonym: "regulation of ion transmembrane transport" BROAD [] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport relationship: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of ion membrane transport" EXACT [] synonym: "negative regulation of ion transmembrane transport" BROAD [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport relationship: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of ion membrane transport" EXACT [] synonym: "positive regulation of ion transmembrane transport" BROAD [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport relationship: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport [Term] id: GO:0034769 name: basement membrane disassembly namespace: biological_process alt_id: GO:0060881 def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. synonym: "basal lamina disassembly" RELATED [] is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0071711 ! basement membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005604 ! results in disassembly of basement membrane relationship: RO:0002590 GO:0005604 ! results in disassembly of basement membrane created_by: dph creation_date: 2009-08-13T11:27:24Z [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004141 ! results in development of heart tube relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007507 ! heart development relationship: part_of GO:0048568 ! embryonic organ development relationship: RO:0002296 UBERON:0004141 ! results in development of heart tube [Term] id: GO:0035051 name: cardiocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] synonym: "cardiac cell differentiation" EXACT [] synonym: "heart cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007507 ! heart development relationship: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process alt_id: GO:0035083 alt_id: GO:0035084 def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005930 ! results in assembly of axoneme relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0060271 ! cilium assembly relationship: RO:0002588 GO:0005930 ! results in assembly of axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0035107 name: appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048736 ! appendage development relationship: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage [Term] id: GO:0035112 name: genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] synonym: "genital morphogenesis" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system relationship: part_of GO:0048806 ! genitalia development relationship: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000025 ! results in formation of anatomical entity tube relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0035239 ! tube morphogenesis relationship: RO:0002297 UBERON:0000025 ! results in formation of anatomical entity tube [Term] id: GO:0035190 name: syncytial nuclear migration namespace: biological_process def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] is_a: GO:0007097 ! nuclear migration intersection_of: GO:0007097 ! nuclear migration intersection_of: BFO:0000066 CL:0000228 ! occurs in multinucleate cell relationship: BFO:0000066 CL:0000228 ! occurs in multinucleate cell relationship: in_taxon NCBITaxon:50557 ! Insecta relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0035234 name: ectopic germ cell programmed cell death namespace: biological_process def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] synonym: "programmed cell death of ectopic germ cells" EXACT [] synonym: "programmed cell death, ectopic germ cells" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000066 CL:0000586 ! occurs in germ cell relationship: BFO:0000066 CL:0000586 ! occurs in germ cell [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0035295 ! tube development relationship: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube [Term] id: GO:0035260 name: internal genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia relationship: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia [Term] id: GO:0035261 name: external genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia relationship: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia [Term] id: GO:0035262 name: gonad morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad relationship: part_of GO:0008406 ! gonad development relationship: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism relationship: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000062 ! results in growth of organ relationship: RO:0002343 UBERON:0000062 ! results in growth of organ property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000949 ! results in development of endocrine system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0000949 ! results in development of endocrine system [Term] id: GO:0035272 name: exocrine system development namespace: biological_process def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002330 ! results in development of exocrine system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0002330 ! results in development of exocrine system [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000025 ! results in development of tube relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007275 ! multicellular organism development relationship: RO:0002296 UBERON:0000025 ! results in development of tube [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005874 ! has target end location microtubule relationship: RO:0002339 GO:0005874 ! has target end location microtubule created_by: bf creation_date: 2010-03-11T11:00:56Z [Term] id: GO:0035418 name: protein localization to synapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] synonym: "protein localisation to synapse" EXACT [GOC:mah] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0045202 ! has target end location synapse relationship: RO:0002339 GO:0045202 ! has target end location synapse created_by: bf creation_date: 2010-03-29T10:58:53Z [Term] id: GO:0035433 name: acetate transmembrane transport namespace: biological_process def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "acetate membrane transport" EXACT [] is_a: GO:0006846 ! acetate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate created_by: bf creation_date: 2010-04-08T10:59:01Z [Term] id: GO:0035441 name: cell migration involved in vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0001570 ! vasculogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001570 ! vasculogenesis created_by: bf creation_date: 2010-04-09T03:53:01Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling pathway" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure created_by: bf creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071692 ! protein localization to extracellular region intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: bf creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0035622 name: intrahepatic bile duct development namespace: biological_process def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] synonym: "IHBD development" EXACT [PMID:20614624] synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003704 ! results in development of intrahepatic bile duct relationship: part_of GO:0001889 ! liver development relationship: RO:0002296 UBERON:0003704 ! results in development of intrahepatic bile duct created_by: bf creation_date: 2010-12-08T04:10:50Z [Term] id: GO:0035628 name: cystic duct development namespace: biological_process def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct." [PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001152 ! results in development of cystic duct relationship: RO:0002296 UBERON:0001152 ! results in development of cystic duct created_by: bf creation_date: 2010-12-10T01:24:28Z [Term] id: GO:0035645 name: enteric smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002504 ! results in acquisition of features of enteric smooth muscle cell relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002315 CL:0002504 ! results in acquisition of features of enteric smooth muscle cell created_by: bf creation_date: 2011-01-21T02:58:58Z [Term] id: GO:0035725 name: sodium ion transmembrane transport namespace: biological_process def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "sodium ion membrane transport" EXACT [] is_a: GO:0006814 ! sodium ion transport is_a: GO:0098655 ! monoatomic cation transmembrane transport is_a: GO:0098662 ! inorganic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29101 ! has primary input sodium(1+) created_by: bf creation_date: 2011-03-10T02:52:36Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924 "Intraflagellar transport" is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: part_of GO:0060271 ! cilium assembly relationship: part_of GO:0060271 ! cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: bf creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035736 name: cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001745 ! compound eye morphogenesis relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0001745 ! compound eye morphogenesis created_by: bf creation_date: 2011-03-17T10:57:03Z [Term] id: GO:0035773 name: insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0030073 ! insulin secretion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0030073 ! insulin secretion intersection_of: part_of GO:0071333 ! cellular response to glucose stimulus relationship: part_of GO:0071333 ! cellular response to glucose stimulus created_by: bf creation_date: 2011-04-01T01:14:40Z [Term] id: GO:0035774 name: positive regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] is_a: GO:0032024 ! positive regulation of insulin secretion is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035773 ! positively regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002213 GO:0035773 ! positively regulates insulin secretion involved in cellular response to glucose stimulus created_by: bf creation_date: 2011-04-01T01:49:09Z [Term] id: GO:0035779 name: angioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001568 ! blood vessel development relationship: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell created_by: bf creation_date: 2011-04-04T11:10:38Z [Term] id: GO:0035834 name: indole alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] synonym: "indole alkaloid metabolism" EXACT [GOC:bf] is_a: GO:0009820 ! alkaloid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:38958 ! has primary input or output indole alkaloid relationship: RO:0004007 CHEBI:38958 ! has primary input or output indole alkaloid created_by: bf creation_date: 2011-05-04T03:17:44Z [Term] id: GO:0035835 name: indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] synonym: "indole alkaloid anabolism" EXACT [GOC:bf] synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf] synonym: "indole alkaloid formation" EXACT [GOC:bf] synonym: "indole alkaloid synthesis" EXACT [GOC:bf] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0035834 ! indole alkaloid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:38958 ! has primary output indole alkaloid relationship: RO:0004008 CHEBI:38958 ! has primary output indole alkaloid created_by: bf creation_date: 2011-05-04T03:18:31Z [Term] id: GO:0035844 name: cloaca development namespace: biological_process def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] synonym: "cloacal development" EXACT [GOC:bf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000162 ! results in development of cloaca relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001655 ! urogenital system development relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: RO:0002296 UBERON:0000162 ! results in development of cloaca created_by: bf creation_date: 2011-05-06T01:54:35Z [Term] id: GO:0035855 name: megakaryocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] synonym: "megakaryocyte cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000556 ! results in development of megakaryocyte relationship: part_of GO:0030219 ! megakaryocyte differentiation relationship: RO:0002296 CL:0000556 ! results in development of megakaryocyte created_by: bf creation_date: 2011-05-13T01:28:06Z [Term] id: GO:0035869 name: ciliary transition zone namespace: cellular_component def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230] comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. synonym: "cilial transition zone" EXACT [] synonym: "cilium transition zone" EXACT [] synonym: "connecting cilium" RELATED [] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005929 ! cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: bf creation_date: 2011-05-25T03:09:58Z [Term] id: GO:0035883 name: enteroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000164 ! results in acquisition of features of enteroendocrine cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002315 CL:0000164 ! results in acquisition of features of enteroendocrine cell created_by: bf creation_date: 2011-06-06T11:48:51Z [Term] id: GO:0035886 name: vascular associated smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular smooth muscle cell differentiation" EXACT [] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001944 ! vasculature development relationship: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell created_by: bf creation_date: 2011-06-08T11:23:52Z [Term] id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell relationship: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell created_by: bf creation_date: 2011-06-08T11:34:26Z [Term] id: GO:0035904 name: aorta development namespace: biological_process def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0060840 ! artery development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000947 ! results in development of aorta relationship: RO:0002296 UBERON:0000947 ! results in development of aorta created_by: bf creation_date: 2011-06-24T11:00:07Z [Term] id: GO:0035905 name: ascending aorta development namespace: biological_process def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001496 ! results in development of ascending aorta relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035904 ! aorta development relationship: RO:0002296 UBERON:0001496 ! results in development of ascending aorta created_by: bf creation_date: 2011-06-24T11:02:01Z [Term] id: GO:0035906 name: descending aorta development namespace: biological_process def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001514 ! results in development of descending aorta relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035904 ! aorta development relationship: RO:0002296 UBERON:0001514 ! results in development of descending aorta created_by: bf creation_date: 2011-06-24T11:05:22Z [Term] id: GO:0035907 name: dorsal aorta development namespace: biological_process def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035904 ! aorta development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta relationship: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta created_by: bf creation_date: 2011-06-24T11:07:01Z [Term] id: GO:0035909 name: aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta relationship: part_of GO:0035904 ! aorta development relationship: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta created_by: bf creation_date: 2011-06-24T11:11:11Z [Term] id: GO:0035910 name: ascending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035905 ! ascending aorta development relationship: part_of GO:0035909 ! aorta morphogenesis relationship: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta created_by: bf creation_date: 2011-06-24T11:14:52Z [Term] id: GO:0035911 name: descending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035906 ! descending aorta development relationship: part_of GO:0035909 ! aorta morphogenesis relationship: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta created_by: bf creation_date: 2011-06-24T11:19:24Z [Term] id: GO:0035912 name: dorsal aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035909 ! aorta morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta relationship: part_of GO:0035907 ! dorsal aorta development relationship: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta created_by: bf creation_date: 2011-06-24T11:22:14Z [Term] id: GO:0035914 name: skeletal muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007519 ! skeletal muscle tissue development relationship: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle created_by: bf creation_date: 2011-06-24T02:36:19Z [Term] id: GO:0035929 name: steroid hormone secretion namespace: biological_process def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl] is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:26764 ! has primary input steroid hormone relationship: RO:0004009 CHEBI:26764 ! has primary input steroid hormone property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: bf creation_date: 2011-07-20T01:01:00Z [Term] id: GO:0035935 name: androgen secretion namespace: biological_process def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl] is_a: GO:0035929 ! steroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: bf creation_date: 2011-07-20T01:11:31Z [Term] id: GO:0035987 name: endodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332] synonym: "endoderm cell differentiation" EXACT [CL:0000223] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0001706 ! endoderm formation relationship: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell created_by: bf creation_date: 2011-08-25T04:50:36Z [Term] id: GO:0035989 name: tendon development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043] synonym: "sinew development" RELATED [UBERON:0000043] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000043 ! results in development of tendon relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0000043 ! results in development of tendon created_by: bf creation_date: 2011-08-26T04:14:30Z [Term] id: GO:0035992 name: tendon formation namespace: biological_process def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000043 ! results in formation of anatomical entity tendon relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035989 ! tendon development relationship: RO:0002297 UBERON:0000043 ! results in formation of anatomical entity tendon created_by: bf creation_date: 2011-08-30T01:35:10Z [Term] id: GO:0036072 name: direct ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034] is_a: GO:0001503 ! ossification created_by: bf creation_date: 2011-12-19T01:47:22Z [Term] id: GO:0036093 name: germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000586 ! acts on population of germ cell relationship: part_of GO:0007276 ! gamete generation relationship: RO:0012003 CL:0000586 ! acts on population of germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2012-01-17T04:06:27Z [Term] id: GO:0036194 name: muscle cell projection namespace: cellular_component def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] synonym: "muscle arm" NARROW [GOC:kmv] synonym: "myocyte projection" EXACT [CL:0000187] synonym: "myopodia" NARROW [GOC:kmv] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: part_of CL:0000187 ! muscle cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000187 ! muscle cell created_by: bf creation_date: 2012-04-20T10:20:47Z [Term] id: GO:0036195 name: muscle cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] is_a: GO:0031253 ! cell projection membrane intersection_of: GO:0031253 ! cell projection membrane intersection_of: part_of GO:0036194 ! muscle cell projection relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0036194 ! muscle cell projection created_by: bf creation_date: 2012-04-20T10:21:51Z [Term] id: GO:0036293 name: response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. synonym: "response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels created_by: bf creation_date: 2012-07-20T01:05:46Z [Term] id: GO:0036333 name: hepatocyte homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874] is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000182 ! acts on population of hepatocyte relationship: RO:0012003 CL:0000182 ! acts on population of hepatocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: bf creation_date: 2012-09-05T10:17:07Z [Term] id: GO:0036334 name: epidermal stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529] is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis relationship: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: bf creation_date: 2012-09-05T10:21:23Z [Term] id: GO:0036342 name: post-anal tail morphogenesis namespace: biological_process def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007812 ! results in morphogenesis of post-anal tail relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002298 UBERON:0007812 ! results in morphogenesis of post-anal tail created_by: bf creation_date: 2012-09-11T13:54:49Z [Term] id: GO:0036477 name: somatodendritic compartment namespace: cellular_component def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000540 ! neuron created_by: bf creation_date: 2014-07-24T10:06:19Z [Term] id: GO:0036504 name: Golgi membrane fusion namespace: biological_process def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691] synonym: "Golgi apparatus membrane fusion" EXACT [] synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf] synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609] is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane relationship: part_of GO:0090168 ! Golgi reassembly relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane created_by: bf creation_date: 2015-05-21T10:05:06Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process relationship: in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040007 ! regulates growth relationship: RO:0002211 GO:0040007 ! regulates growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040011 ! regulates locomotion relationship: RO:0002211 GO:0040011 ! regulates locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040011 ! negatively regulates locomotion relationship: RO:0002212 GO:0040011 ! negatively regulates locomotion [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035264 ! regulates multicellular organism growth relationship: RO:0002211 GO:0035264 ! regulates multicellular organism growth [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth relationship: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0009790 ! embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040011 ! positively regulates locomotion relationship: RO:0002213 GO:0040011 ! positively regulates locomotion [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth relationship: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009790 ! positively regulates embryo development relationship: RO:0002213 GO:0009790 ! positively regulates embryo development [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140013 ! regulates meiotic nuclear division relationship: RO:0002211 GO:0140013 ! regulates meiotic nuclear division [Term] id: GO:0040034 name: regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] synonym: "developmental timing" RELATED [] synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0042063 name: gliogenesis namespace: biological_process def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] synonym: "glial cell generation" EXACT systematic_synonym [] is_a: GO:0022008 ! neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002297 CL:0000125 ! results in formation of anatomical entity glial cell relationship: RO:0002297 CL:0000125 ! results in formation of anatomical entity glial cell [Term] id: GO:0042065 name: glial cell growth namespace: biological_process def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000125 ! results in growth of glial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0042063 ! gliogenesis relationship: RO:0002343 CL:0000125 ! results in growth of glial cell [Term] id: GO:0042069 name: regulation of catecholamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] synonym: "regulation of catecholamine metabolism" EXACT [] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process relationship: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process alt_id: GO:0035734 def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005929 ! occurs in cilium intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: BFO:0000066 GO:0005929 ! occurs in cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0044782 ! cilium organization property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, PMID:16099638] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007369 ! gastrulation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process alt_id: GO:0048131 def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007281 ! germ cell development relationship: RO:0004009 CL:0000014 ! has primary input germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008283 ! regulates cell population proliferation relationship: RO:0002211 GO:0008283 ! regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process alt_id: GO:1903362 alt_id: GO:2000598 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process" EXACT [] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "regulation of cyclin catabolic process" NARROW [] synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "regulation of cyclin degradation" NARROW [GOC:obol] synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030163 ! regulates protein catabolic process relationship: RO:0002211 GO:0030163 ! regulates protein catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI created_by: kmv creation_date: 2014-08-21T15:05:45Z [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process alt_id: GO:1903363 alt_id: GO:2000599 def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process" EXACT [] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process relationship: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0042180 name: ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir synonym: "ketone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17087 ! has primary input or output ketone relationship: RO:0004007 CHEBI:17087 ! has primary input or output ketone property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! ketone metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17087 ! has primary output ketone relationship: RO:0004008 CHEBI:17087 ! has primary output ketone [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! ketone metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17087 ! has primary input ketone relationship: RO:0004009 CHEBI:17087 ! has primary input ketone [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0042255 name: ribosome assembly namespace: biological_process alt_id: GO:0042257 def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] subset: goslim_yeast synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005840 ! results in assembly of ribosome relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0042254 ! ribosome biogenesis relationship: RO:0002588 GO:0005840 ! results in assembly of ribosome [Term] id: GO:0042391 name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] is_a: GO:0065008 ! regulation of biological quality relationship: has_part GO:0034220 ! monoatomic ion transmembrane transport [Term] id: GO:0042401 name: biogenic amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine anabolism" EXACT [] synonym: "biogenic amine biosynthesis" EXACT [] synonym: "biogenic amine formation" EXACT [] synonym: "biogenic amine synthesis" EXACT [] synonym: "cellular biogenic amine biosynthetic process" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0042402 name: biogenic amine catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] synonym: "biogenic amine breakdown" EXACT [] synonym: "biogenic amine catabolism" EXACT [] synonym: "biogenic amine degradation" EXACT [] is_a: GO:0009310 ! amine catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0042415 name: norepinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol metabolic process" EXACT [] synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:72587 ! has primary input or output (R)-noradrenaline(1+) relationship: RO:0004007 CHEBI:72587 ! has primary input or output (R)-noradrenaline(1+) [Term] id: GO:0042421 name: norepinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol biosynthesis" EXACT [] synonym: "levarterenol biosynthetic process" EXACT [] synonym: "noradrenaline biosynthesis" EXACT [] synonym: "noradrenaline biosynthetic process" EXACT [] synonym: "norepinephrine anabolism" EXACT [] synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:72587 ! has primary output (R)-noradrenaline(1+) relationship: RO:0004008 CHEBI:72587 ! has primary output (R)-noradrenaline(1+) [Term] id: GO:0042422 name: norepinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol catabolic process" EXACT [] synonym: "levarterenol catabolism" EXACT [] synonym: "noradrenaline catabolic process" EXACT [] synonym: "noradrenaline catabolism" EXACT [] synonym: "norepinephrine breakdown" EXACT [] synonym: "norepinephrine catabolism" EXACT [] synonym: "norepinephrine degradation" EXACT [] xref: Wikipedia:Norepinephrine#Degradation is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) relationship: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) [Term] id: GO:0042423 name: catecholamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine anabolism" EXACT [] synonym: "catecholamine biosynthesis" EXACT [] synonym: "catecholamine formation" EXACT [] synonym: "catecholamine synthesis" EXACT [] xref: Reactome:R-HSA-209905 "Catecholamine biosynthesis" xref: Wikipedia:Catecholamines is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0042401 ! biogenic amine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33567 ! has primary output catecholamine relationship: RO:0004008 CHEBI:33567 ! has primary output catecholamine [Term] id: GO:0042424 name: catecholamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine breakdown" EXACT [] synonym: "catecholamine catabolism" EXACT [] synonym: "catecholamine degradation" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042402 ! biogenic amine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine relationship: RO:0004009 CHEBI:33567 ! has primary input catecholamine [Term] id: GO:0042427 name: serotonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism" EXACT [] synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:350546 ! has primary output serotonin(1+) relationship: RO:0004008 CHEBI:350546 ! has primary output serotonin(1+) [Term] id: GO:0042428 name: serotonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:350546 ! has primary input or output serotonin(1+) relationship: RO:0004007 CHEBI:350546 ! has primary input or output serotonin(1+) [Term] id: GO:0042429 name: serotonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] xref: Reactome:R-HSA-380612 "Metabolism of serotonin" is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1901161 ! primary amino compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) relationship: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) [Term] id: GO:0042430 name: indole-containing compound metabolic process namespace: biological_process alt_id: GO:0042434 def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah] synonym: "indole and derivative metabolic process" EXACT [] synonym: "indole and derivative metabolism" EXACT [] synonym: "indole derivative metabolic process" NARROW [] synonym: "indole derivative metabolism" NARROW [] synonym: "indole-containing compound metabolism" EXACT [] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24828 ! has primary input or output indoles relationship: RO:0004007 CHEBI:24828 ! has primary input or output indoles [Term] id: GO:0042435 name: indole-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative biosynthesis" EXACT [] synonym: "indole derivative biosynthetic process" EXACT [] synonym: "indole-containing compound anabolism" EXACT [] synonym: "indole-containing compound biosynthesis" EXACT [] synonym: "indole-containing compound formation" EXACT [] synonym: "indole-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24828 ! has primary output indoles relationship: RO:0004008 CHEBI:24828 ! has primary output indoles [Term] id: GO:0042436 name: indole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative catabolic process" EXACT [] synonym: "indole derivative catabolism" EXACT [] synonym: "indole-containing compound breakdown" EXACT [] synonym: "indole-containing compound catabolism" EXACT [] synonym: "indole-containing compound degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24828 ! has primary input indoles relationship: RO:0004009 CHEBI:24828 ! has primary input indoles [Term] id: GO:0042461 name: photoreceptor cell development namespace: biological_process alt_id: GO:0046531 def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] synonym: "photoreceptor morphogenesis" EXACT [] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000210 ! results in development of photoreceptor cell relationship: part_of GO:0046530 ! photoreceptor cell differentiation relationship: RO:0002296 CL:0000210 ! results in development of photoreceptor cell [Term] id: GO:0042462 name: eye photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] is_a: GO:0042461 ! photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation relationship: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell [Term] id: GO:0042478 name: regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "regulation of eye photoreceptor development" EXACT [] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development relationship: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development [Term] id: GO:0042479 name: positive regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "activation of eye photoreceptor cell development" NARROW [] synonym: "positive regulation of eye photoreceptor development" EXACT [] synonym: "stimulation of eye photoreceptor cell development" NARROW [] synonym: "up regulation of eye photoreceptor cell development" EXACT [] synonym: "up-regulation of eye photoreceptor cell development" EXACT [] synonym: "upregulation of eye photoreceptor cell development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development relationship: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development [Term] id: GO:0042480 name: negative regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "down regulation of eye photoreceptor cell development" EXACT [] synonym: "down-regulation of eye photoreceptor cell development" EXACT [] synonym: "downregulation of eye photoreceptor cell development" EXACT [] synonym: "inhibition of eye photoreceptor cell development" NARROW [] synonym: "negative regulation of eye photoreceptor development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development relationship: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000540 ! results in maturation of neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048666 ! neuron development relationship: RO:0002299 CL:0000540 ! results in maturation of neuron [Term] id: GO:0042588 name: zymogen granule namespace: cellular_component def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732] is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042589 name: zymogen granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0042588 ! zymogen granule relationship: bounding_layer_of GO:0042588 ! zymogen granule relationship: part_of GO:0042588 ! zymogen granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042592 name: homeostatic process namespace: biological_process alt_id: GO:0032844 alt_id: GO:0032845 alt_id: GO:0032846 def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] is_a: GO:0033500 ! carbohydrate homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of D-glucopyranose relationship: RO:0002332 CHEBI:4167 ! regulates levels of D-glucopyranose [Term] id: GO:0042641 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] synonym: "actomyosin complex" EXACT [] synonym: "actomyosin structure" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0042670 name: retinal cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell relationship: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] synonym: "myogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0061061 ! muscle structure development relationship: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell [Term] id: GO:0042762 name: regulation of sulfur metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] synonym: "regulation of sulfur metabolism" EXACT [] synonym: "regulation of sulphur metabolic process" EXACT [] synonym: "regulation of sulphur metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006790 ! regulates sulfur compound metabolic process relationship: RO:0002211 GO:0006790 ! regulates sulfur compound metabolic process [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide relationship: RO:0004009 CHEBI:32988 ! has primary input amide [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide relationship: part_of GO:0042886 ! amide transport relationship: RO:0004009 CHEBI:32988 ! has primary input amide [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] xref: Reactome:R-HSA-169911 "Regulation of Apoptosis" xref: Reactome:R-HSA-5633008 "TP53 Regulates Transcription of Cell Death Genes" is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006915 ! regulates apoptotic process relationship: RO:0002211 GO:0006915 ! regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell [Term] id: GO:0042996 name: regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport relationship: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport [Term] id: GO:0042997 name: negative regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport relationship: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport [Term] id: GO:0042998 name: positive regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport relationship: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport [Term] id: GO:0043001 name: Golgi to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] is_a: GO:0006893 ! Golgi to plasma membrane transport is_a: GO:0015031 ! protein transport is_a: GO:0061951 ! establishment of protein localization to plasma membrane intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] subset: goslim_pir synonym: "nerve fiber" RELATED [GOC:dph] synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao867568886 is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: part_of CL:0000540 ! neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000540 ! neuron [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: in_taxon NCBITaxon:7711 ! Chordata [Term] id: GO:0043010 name: camera-type eye development namespace: biological_process alt_id: GO:0001747 alt_id: GO:0031075 def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000019 ! results in development of camera-type eye relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0000019 ! results in development of camera-type eye [Term] id: GO:0043025 name: neuronal cell body namespace: cellular_component def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "neuron cell body" EXACT [] synonym: "neuronal cell soma" EXACT [] xref: NIF_Subcellular:sao1044911821 xref: Wikipedia:Soma_(biology) is_a: GO:0044297 ! cell body intersection_of: GO:0044297 ! cell body intersection_of: part_of CL:0000540 ! neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0036477 ! somatodendritic compartment [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] xref: Reactome:R-HSA-9037628 "Rhesus blood group biosynthesis" is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion relationship: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: goslim_prokaryote synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005576 ! results in organization of extracellular region relationship: RO:0002592 GO:0005576 ! results in organization of extracellular region [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] xref: Reactome:R-HSA-193648 "NRAGE signals death through JNK" xref: Reactome:R-HSA-205043 "NRIF signals cell death from the nucleus" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006915 ! positively regulates apoptotic process relationship: RO:0002213 GO:0006915 ! positively regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process alt_id: GO:0006916 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] xref: Reactome:R-HSA-193639 "p75NTR signals via NF-kB" xref: Reactome:R-HSA-211728 "Regulation of PAK-2p34 activity by PS-GAP/RHG10" xref: Reactome:R-HSA-211733 "Regulation of activated PAK-2p34 by proteasome mediated degradation" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006915 ! negatively regulates apoptotic process relationship: RO:0002212 GO:0006915 ! negatively regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0012501 ! regulates programmed cell death relationship: RO:0002211 GO:0012501 ! regulates programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process alt_id: GO:0043071 def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0012501 ! positively regulates programmed cell death relationship: RO:0002213 GO:0012501 ! positively regulates programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process alt_id: GO:0043072 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0012501 ! negatively regulates programmed cell death relationship: RO:0002212 GO:0012501 ! negatively regulates programmed cell death [Term] id: GO:0043073 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] synonym: "germ-cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: part_of CL:0000586 ! germ cell relationship: part_of CL:0000586 ! germ cell [Term] id: GO:0043083 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, PMID:30784960] subset: goslim_synapse xref: NIF_Subcellular:sao243541954 is_a: GO:0005576 ! extracellular region relationship: adjacent_to GO:0045202 ! synapse [Term] id: GO:0043133 name: hindgut contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0022600 ! digestive system process intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0001046 ! occurs in hindgut relationship: BFO:0000066 UBERON:0001046 ! occurs in hindgut property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043134 name: regulation of hindgut contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043133 ! regulates hindgut contraction relationship: RO:0002211 GO:0043133 ! regulates hindgut contraction [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0006412 ! translation relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0006412 ! translation [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule relationship: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0043200 name: response to amino acid namespace: biological_process alt_id: GO:0010237 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg] synonym: "response to amino acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: has_part GO:0016020 ! membrane disjoint_from: GO:0043228 ! membraneless organelle relationship: has_part GO:0016020 ! membrane property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28153 xsd:anyURI [Term] id: GO:0043228 name: membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_mouse synonym: "biological condensate" RELATED [] synonym: "membrane-less organelle" EXACT [] synonym: "non-membrane-bounded organelle" EXACT [] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21881 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28153 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29106 xsd:anyURI [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure disjoint_from: GO:0043230 ! extracellular organelle relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28153 xsd:anyURI [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043232 name: intracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_pir synonym: "intracellular non-membrane-bounded organelle" EXACT [] synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29106 xsd:anyURI [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] subset: goslim_mouse is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0043242 name: negative regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] synonym: "negative regulation of protein complex disassembly" RELATED [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly relationship: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly [Term] id: GO:0043243 name: positive regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "positive regulation of protein complex disassembly" RELATED [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly relationship: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly [Term] id: GO:0043244 name: regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "regulation of protein complex disassembly" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly relationship: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly [Term] id: GO:0043249 name: erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] synonym: "RBC maturation" EXACT [CL:0000232] synonym: "red blood cell maturation" EXACT [CL:0000232] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000232 ! results in maturation of erythrocyte relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048821 ! erythrocyte development relationship: RO:0002299 CL:0000232 ! results in maturation of erythrocyte [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly relationship: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly [Term] id: GO:0043255 name: regulation of carbohydrate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] synonym: "regulation of carbohydrate anabolism" EXACT [] synonym: "regulation of carbohydrate biosynthesis" EXACT [] synonym: "regulation of carbohydrate formation" EXACT [] synonym: "regulation of carbohydrate synthesis" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process relationship: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process [Term] id: GO:0043264 name: extracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] synonym: "extracellular non-membrane-bounded organelle" EXACT [] synonym: "extracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: part_of GO:0005576 ! extracellular region property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29106 xsd:anyURI [Term] id: GO:0043269 name: regulation of monoatomic ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of ion transport" BROAD [] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006811 ! regulates monoatomic ion transport relationship: RO:0002211 GO:0006811 ! regulates monoatomic ion transport [Term] id: GO:0043270 name: positive regulation of monoatomic ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport relationship: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport [Term] id: GO:0043271 name: negative regulation of monoatomic ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] synonym: "negative regulation of ion transport" BROAD [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport relationship: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport [Term] id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid relationship: RO:0004009 CHEBI:22315 ! has primary input alkaloid [Term] id: GO:0043292 name: contractile muscle fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] is_a: GO:0043232 ! intracellular membraneless organelle is_a: GO:0099512 ! supramolecular fiber relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000187 ! muscle cell relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27281 xsd:anyURI [Term] id: GO:0043362 name: nucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] synonym: "nucleate RBC maturation" EXACT [CL:0000232] synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte relationship: part_of GO:0048823 ! nucleate erythrocyte development relationship: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte [Term] id: GO:0043363 name: nucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] synonym: "nucleate RBC differentiation" EXACT [CL:0000232] synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte relationship: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte [Term] id: GO:0043434 name: response to peptide hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input peptide hormone relationship: RO:0004009 CHEBI:25905 ! has primary input peptide hormone property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion relationship: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion [Term] id: GO:0043455 name: regulation of secondary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] synonym: "regulation of secondary metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019748 ! regulates secondary metabolic process relationship: RO:0002211 GO:0019748 ! regulates secondary metabolic process [Term] id: GO:0043467 name: regulation of generation of precursor metabolites and energy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] xref: Reactome:R-HSA-163685 "Integration of energy metabolism" is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006091 ! regulates generation of precursor metabolites and energy relationship: RO:0002211 GO:0006091 ! regulates generation of precursor metabolites and energy [Term] id: GO:0043470 name: regulation of carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process relationship: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process relationship: in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: GO:0043500 name: muscle adaptation namespace: biological_process def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] subset: goslim_pir synonym: "muscle plasticity" RELATED [] is_a: GO:0003012 ! muscle system process is_a: GO:0050896 ! response to stimulus relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043501 name: skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043502 name: regulation of muscle adaptation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] synonym: "regulation of muscle plasticity" RELATED [] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043500 ! regulates muscle adaptation relationship: RO:0002211 GO:0043500 ! regulates muscle adaptation [Term] id: GO:0043523 name: regulation of neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of neuronal cells" EXACT [] synonym: "regulation of apoptosis of neurons" EXACT [] synonym: "regulation of neuron apoptosis" NARROW [] synonym: "regulation of neuron programmed cell death" EXACT [] synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051402 ! regulates neuron apoptotic process relationship: RO:0002211 GO:0051402 ! regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043524 name: negative regulation of neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of neuron apoptosis" EXACT [] synonym: "down-regulation of neuron apoptosis" EXACT [] synonym: "downregulation of neuron apoptosis" EXACT [] synonym: "inhibition of neuron apoptosis" NARROW [] synonym: "negative regulation of neuron apoptosis" NARROW [] synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process relationship: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043525 name: positive regulation of neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of neuron apoptosis" NARROW [] synonym: "positive regulation of neuron apoptosis" NARROW [] synonym: "positive regulation of programmed cell death, neurons" EXACT [] synonym: "stimulation of neuron apoptosis" NARROW [] synonym: "up regulation of neuron apoptosis" EXACT [] synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process relationship: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system relationship: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system [Term] id: GO:0043588 name: skin development namespace: biological_process def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] synonym: "animal skin development" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002097 ! results in development of skin of body relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: RO:0002296 UBERON:0002097 ! results in development of skin of body [Term] id: GO:0043589 name: skin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0043588 ! skin development relationship: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body [Term] id: GO:0043603 name: amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "amide metabolism" EXACT [] synonym: "cellular amide metabolic process" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32988 ! has primary input or output amide relationship: RO:0004007 CHEBI:32988 ! has primary input or output amide property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide relationship: RO:0004008 CHEBI:32988 ! has primary output amide [Term] id: GO:0043605 name: amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] synonym: "cellular amide catabolic process" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide relationship: RO:0004008 CHEBI:32988 ! has primary output amide [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion relationship: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion [Term] id: GO:0043649 name: dicarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate catabolic process" EXACT [] synonym: "dicarboxylate catabolism" EXACT [] synonym: "dicarboxylic acid breakdown" EXACT [] synonym: "dicarboxylic acid catabolism" EXACT [] synonym: "dicarboxylic acid degradation" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate biosynthesis" EXACT [] synonym: "dicarboxylate biosynthetic process" EXACT [] synonym: "dicarboxylic acid anabolism" EXACT [] synonym: "dicarboxylic acid biosynthesis" EXACT [] synonym: "dicarboxylic acid formation" EXACT [] synonym: "dicarboxylic acid synthesis" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion relationship: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion [Term] id: GO:0043931 name: ossification involved in bone maturation namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034] synonym: "ossification involved in skeletal development" EXACT [GOC:dph] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: part_of GO:0070977 ! bone maturation relationship: part_of GO:0070977 ! bone maturation [Term] id: GO:0043933 name: protein-containing complex organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 alt_id: GO:0071822 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] synonym: "protein-containing complex subunit organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032991 ! results in organization of protein-containing complex relationship: RO:0002592 GO:0032991 ! results in organization of protein-containing complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22580 xsd:anyURI created_by: mah creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0044042 name: glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:37163 ! has primary input or output glucan relationship: RO:0004007 CHEBI:37163 ! has primary input or output glucan [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003008 ! regulates system process relationship: RO:0002211 GO:0003008 ! regulates system process [Term] id: GO:0044058 name: regulation of digestive system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022600 ! regulates digestive system process relationship: RO:0002211 GO:0022600 ! regulates digestive system process [Term] id: GO:0044060 name: regulation of endocrine process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] synonym: "regulation of endocrine system process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050886 ! regulates endocrine process relationship: RO:0002211 GO:0050886 ! regulates endocrine process [Term] id: GO:0044062 name: regulation of excretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] is_a: GO:0044057 ! regulation of system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007588 ! regulates excretion relationship: RO:0002211 GO:0007588 ! regulates excretion [Term] id: GO:0044065 name: regulation of respiratory system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003016 ! regulates respiratory system process relationship: RO:0002211 GO:0003016 ! regulates respiratory system process [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27194 xsd:anyURI [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044085 ! regulates cellular component biogenesis relationship: RO:0002211 GO:0044085 ! regulates cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007033 ! regulates vacuole organization relationship: RO:0002211 GO:0007033 ! regulates vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis relationship: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007033 ! positively regulates vacuole organization relationship: RO:0002213 GO:0007033 ! positively regulates vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0016020 ! has primary output membrane relationship: RO:0004008 GO:0016020 ! has primary output membrane [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_do_not_annotate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003674 ! negatively regulates molecular_function relationship: RO:0002212 GO:0003674 ! negatively regulates molecular_function created_by: jl creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_obsoletion_candidate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003674 ! positively regulates molecular_function relationship: RO:0002213 GO:0003674 ! positively regulates molecular_function created_by: jl creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005737 ! cytoplasm created_by: jl creation_date: 2009-10-22T02:38:55Z [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "primary metabolism" EXACT [] xref: Wikipedia:Primary_metabolite is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI [Term] id: GO:0044258 name: intestinal lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, PMID:7018485] synonym: "intestinal lipid breakdown" EXACT [] synonym: "intestinal lipid catabolism" EXACT [] synonym: "intestinal lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0016042 ! lipid catabolic process intersection_of: BFO:0000066 UBERON:0000160 ! occurs in intestine relationship: BFO:0000066 UBERON:0000160 ! occurs in intestine [Term] id: GO:0044272 name: sulfur compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur biosynthesis" NARROW [] synonym: "sulfur biosynthetic process" NARROW [] synonym: "sulfur compound anabolism" EXACT [] synonym: "sulfur compound biosynthesis" EXACT [] synonym: "sulfur compound formation" EXACT [] synonym: "sulfur compound synthesis" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26835 ! has primary output sulfur molecular entity relationship: RO:0004008 CHEBI:26835 ! has primary output sulfur molecular entity [Term] id: GO:0044273 name: sulfur compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur catabolic process" NARROW [] synonym: "sulfur catabolism" NARROW [] synonym: "sulfur compound breakdown" EXACT [] synonym: "sulfur compound catabolism" EXACT [] synonym: "sulfur compound degradation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity relationship: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process created_by: jl creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process created_by: jl creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044297 name: cell body namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. synonym: "cell soma" EXACT [] xref: FBbt:00005107 xref: FMA:67301 xref: Wikipedia:Cell_body is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of CL:0000000 ! cell property_value: RO:0002161 NCBITaxon:4890 created_by: jl creation_date: 2010-02-05T10:37:16Z [Term] id: GO:0044342 name: type B pancreatic cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "pancreatic beta cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000169 ! acts on population of type B pancreatic cell relationship: RO:0012003 CL:0000169 ! acts on population of type B pancreatic cell property_value: RO:0002161 NCBITaxon:4751 created_by: jl creation_date: 2010-08-25T01:44:51Z [Term] id: GO:0044346 name: fibroblast apoptotic process namespace: biological_process def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf] synonym: "fibroblast apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000057 ! occurs in fibroblast relationship: BFO:0000066 CL:0000057 ! occurs in fibroblast property_value: RO:0002161 NCBITaxon:4896 created_by: jl creation_date: 2010-09-23T11:33:38Z [Term] id: GO:0044380 name: protein localization to cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005856 ! has target end location cytoskeleton relationship: RO:0002339 GO:0005856 ! has target end location cytoskeleton created_by: jl creation_date: 2011-12-13T11:43:24Z [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms namespace: biological_process def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction between organisms" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] xref: Reactome:R-HSA-9824443 "Parasitic Infection Pathways" is_a: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20191 xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0044550 name: secondary metabolite biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] subset: goslim_prokaryote synonym: "secondary metabolite biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019748 ! secondary metabolic process created_by: jl creation_date: 2012-03-29T01:55:18Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila subset: goslim_generic synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005929 ! results in organization of cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: RO:0002592 GO:0005929 ! results in organization of cilium created_by: jl creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process alt_id: GO:0006947 def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0061025 ! membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005886 ! results in fusion of plasma membrane relationship: RO:0012008 GO:0005886 ! results in fusion of plasma membrane [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division [Term] id: GO:0045137 name: development of primary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007275 ! multicellular organism development relationship: part_of GO:0007548 ! sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0030154 ! cell differentiation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24390 xsd:anyURI [Term] id: GO:0045168 name: cell-cell signaling involved in cell fate commitment namespace: biological_process def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell fate commitment, cell-cell signaling" EXACT [] synonym: "cell fate commitment, cell-cell signalling" EXACT [] synonym: "cell-cell signaling during in cell fate commitment" EXACT [] synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] synonym: "cell-cell signalling during cell fate commitment" EXACT [] synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0045165 ! cell fate commitment relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: RO:0004009 CHEBI:36080 ! has primary input protein [Term] id: GO:0045196 name: establishment or maintenance of neuroblast polarity namespace: biological_process alt_id: GO:0043339 alt_id: GO:0043342 def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0055059 ! asymmetric neuroblast division [Term] id: GO:0045200 name: establishment of neuroblast polarity namespace: biological_process alt_id: GO:0043340 alt_id: GO:0043343 def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "establishment of neuroblast cell polarity" EXACT [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) relationship: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] subset: goslim_agr subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_synapse synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: GO:0030054 ! cell junction relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process alt_id: GO:0006938 def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [] is_a: GO:0031032 ! actomyosin structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030017 ! results in organization of sarcomere relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030239 ! myofibril assembly relationship: RO:0002592 GO:0030017 ! results in organization of sarcomere [Term] id: GO:0045216 name: cell-cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "cell-cell junction assembly and maintenance" EXACT [] synonym: "cell-cell junction biogenesis" RELATED [] synonym: "cell-cell junction organisation" EXACT [GOC:mah] synonym: "intercellular junction assembly and maintenance" EXACT [] xref: Reactome:R-HSA-421270 "Cell-cell junction organization" is_a: GO:0034330 ! cell junction organization intersection_of: GO:0034330 ! cell junction organization intersection_of: RO:0002592 GO:0005911 ! results in organization of cell-cell junction relationship: RO:0002592 GO:0005911 ! results in organization of cell-cell junction [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "external encapsulating structure organisation" EXACT [] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure relationship: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure [Term] id: GO:0045444 name: fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] synonym: "adipocyte cell differentiation" EXACT [] synonym: "adipocyte differentiation" EXACT [] synonym: "adipogenesis" RELATED [] synonym: "adipose cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte [Term] id: GO:0045445 name: myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "myoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0061061 ! muscle structure development relationship: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast [Term] id: GO:0045446 name: endothelial cell differentiation namespace: biological_process def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003158 ! endothelium development relationship: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030154 ! regulates cell differentiation relationship: RO:0002211 GO:0030154 ! regulates cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030154 ! negatively regulates cell differentiation relationship: RO:0002212 GO:0030154 ! negatively regulates cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030154 ! positively regulates cell differentiation relationship: RO:0002213 GO:0030154 ! positively regulates cell differentiation [Term] id: GO:0045598 name: regulation of fat cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "regulation of adipocyte cell differentiation" EXACT [] synonym: "regulation of adipocyte differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045444 ! regulates fat cell differentiation relationship: RO:0002211 GO:0045444 ! regulates fat cell differentiation [Term] id: GO:0045599 name: negative regulation of fat cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "down regulation of fat cell differentiation" EXACT [] synonym: "down-regulation of fat cell differentiation" EXACT [] synonym: "downregulation of fat cell differentiation" EXACT [] synonym: "inhibition of fat cell differentiation" NARROW [] synonym: "negative regulation of adipocyte cell differentiation" EXACT [] synonym: "negative regulation of adipocyte differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation relationship: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation [Term] id: GO:0045600 name: positive regulation of fat cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "activation of fat cell differentiation" NARROW [] synonym: "positive regulation of adipocyte cell differentiation" EXACT [] synonym: "positive regulation of adipocyte differentiation" EXACT [] synonym: "stimulation of fat cell differentiation" NARROW [] synonym: "up regulation of fat cell differentiation" EXACT [] synonym: "up-regulation of fat cell differentiation" EXACT [] synonym: "upregulation of fat cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation relationship: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation [Term] id: GO:0045601 name: regulation of endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation relationship: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation [Term] id: GO:0045602 name: negative regulation of endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "down regulation of endothelial cell differentiation" EXACT [] synonym: "down-regulation of endothelial cell differentiation" EXACT [] synonym: "downregulation of endothelial cell differentiation" EXACT [] synonym: "inhibition of endothelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation relationship: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation [Term] id: GO:0045603 name: positive regulation of endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "activation of endothelial cell differentiation" NARROW [] synonym: "stimulation of endothelial cell differentiation" NARROW [] synonym: "up regulation of endothelial cell differentiation" EXACT [] synonym: "up-regulation of endothelial cell differentiation" EXACT [] synonym: "upregulation of endothelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation relationship: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation [Term] id: GO:0045604 name: regulation of epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045682 ! regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation relationship: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation [Term] id: GO:0045605 name: negative regulation of epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "down regulation of epidermal cell differentiation" EXACT [] synonym: "down-regulation of epidermal cell differentiation" EXACT [] synonym: "downregulation of epidermal cell differentiation" EXACT [] synonym: "inhibition of epidermal cell differentiation" NARROW [] synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045683 ! negative regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation relationship: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation [Term] id: GO:0045606 name: positive regulation of epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "activation of epidermal cell differentiation" NARROW [] synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermal cell differentiation" NARROW [] synonym: "up regulation of epidermal cell differentiation" EXACT [] synonym: "up-regulation of epidermal cell differentiation" EXACT [] synonym: "upregulation of epidermal cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045684 ! positive regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation relationship: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8939246 "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells" is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation relationship: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation relationship: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation relationship: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation relationship: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation relationship: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation relationship: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation [Term] id: GO:0045652 name: regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8936459 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation relationship: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation [Term] id: GO:0045653 name: negative regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "down regulation of megakaryocyte differentiation" EXACT [] synonym: "down-regulation of megakaryocyte differentiation" EXACT [] synonym: "downregulation of megakaryocyte differentiation" EXACT [] synonym: "inhibition of megakaryocyte differentiation" NARROW [] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation relationship: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation [Term] id: GO:0045654 name: positive regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "activation of megakaryocyte differentiation" NARROW [] synonym: "stimulation of megakaryocyte differentiation" NARROW [] synonym: "up regulation of megakaryocyte differentiation" EXACT [] synonym: "up-regulation of megakaryocyte differentiation" EXACT [] synonym: "upregulation of megakaryocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation relationship: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation [Term] id: GO:0045661 name: regulation of myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045445 ! regulates myoblast differentiation relationship: RO:0002211 GO:0045445 ! regulates myoblast differentiation [Term] id: GO:0045662 name: negative regulation of myoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "down regulation of myoblast differentiation" EXACT [] synonym: "down-regulation of myoblast differentiation" EXACT [] synonym: "downregulation of myoblast differentiation" EXACT [] synonym: "inhibition of myoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation relationship: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation [Term] id: GO:0045663 name: positive regulation of myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "activation of myoblast differentiation" NARROW [] synonym: "stimulation of myoblast differentiation" NARROW [] synonym: "up regulation of myoblast differentiation" EXACT [] synonym: "up-regulation of myoblast differentiation" EXACT [] synonym: "upregulation of myoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation relationship: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030182 ! regulates neuron differentiation relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002211 GO:0030182 ! regulates neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation relationship: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030182 ! positively regulates neuron differentiation relationship: RO:0002213 GO:0030182 ! positively regulates neuron differentiation [Term] id: GO:0045682 name: regulation of epidermis development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "regulation of epidermal development" EXACT [] synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008544 ! regulates epidermis development relationship: RO:0002211 GO:0008544 ! regulates epidermis development [Term] id: GO:0045683 name: negative regulation of epidermis development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "down regulation of epidermis development" EXACT [] synonym: "down-regulation of epidermis development" EXACT [] synonym: "downregulation of epidermis development" EXACT [] synonym: "inhibition of epidermis development" NARROW [] synonym: "negative regulation of epidermal development" EXACT [] synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008544 ! negatively regulates epidermis development relationship: RO:0002212 GO:0008544 ! negatively regulates epidermis development [Term] id: GO:0045684 name: positive regulation of epidermis development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "activation of epidermis development" NARROW [] synonym: "positive regulation of epidermal development" EXACT [] synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermis development" NARROW [] synonym: "up regulation of epidermis development" EXACT [] synonym: "up-regulation of epidermis development" EXACT [] synonym: "upregulation of epidermis development" EXACT [] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008544 ! positively regulates epidermis development relationship: RO:0002213 GO:0008544 ! positively regulates epidermis development [Term] id: GO:0045685 name: regulation of glial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "regulation of glia cell differentiation" EXACT [] synonym: "regulation of neuroglia differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010001 ! regulates glial cell differentiation relationship: RO:0002211 GO:0010001 ! regulates glial cell differentiation [Term] id: GO:0045686 name: negative regulation of glial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "down regulation of glial cell differentiation" EXACT [] synonym: "down-regulation of glial cell differentiation" EXACT [] synonym: "downregulation of glial cell differentiation" EXACT [] synonym: "inhibition of glial cell differentiation" NARROW [] synonym: "negative regulation of glia cell differentiation" EXACT [] synonym: "negative regulation of neuroglia differentiation" EXACT [] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation relationship: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation [Term] id: GO:0045687 name: positive regulation of glial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "activation of glial cell differentiation" NARROW [] synonym: "positive regulation of glia cell differentiation" EXACT [] synonym: "positive regulation of neuroglia differentiation" EXACT [] synonym: "stimulation of glial cell differentiation" NARROW [] synonym: "up regulation of glial cell differentiation" EXACT [] synonym: "up-regulation of glial cell differentiation" EXACT [] synonym: "upregulation of glial cell differentiation" EXACT [] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation relationship: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation [Term] id: GO:0045719 name: negative regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen biosynthetic process" EXACT [] synonym: "down-regulation of glycogen biosynthetic process" EXACT [] synonym: "downregulation of glycogen biosynthetic process" EXACT [] synonym: "inhibition of glycogen biosynthetic process" NARROW [] synonym: "negative regulation of glycogen anabolism" EXACT [] synonym: "negative regulation of glycogen biosynthesis" EXACT [] synonym: "negative regulation of glycogen formation" EXACT [] synonym: "negative regulation of glycogen synthesis" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005978 ! negatively regulates glycogen biosynthetic process relationship: RO:0002212 GO:0005978 ! negatively regulates glycogen biosynthetic process [Term] id: GO:0045721 name: negative regulation of gluconeogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "down regulation of gluconeogenesis" EXACT [] synonym: "down-regulation of gluconeogenesis" EXACT [] synonym: "downregulation of gluconeogenesis" EXACT [] synonym: "inhibition of gluconeogenesis" NARROW [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006094 ! negatively regulates gluconeogenesis relationship: RO:0002212 GO:0006094 ! negatively regulates gluconeogenesis [Term] id: GO:0045722 name: positive regulation of gluconeogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "activation of gluconeogenesis" NARROW [] synonym: "stimulation of gluconeogenesis" NARROW [] synonym: "up regulation of gluconeogenesis" EXACT [] synonym: "up-regulation of gluconeogenesis" EXACT [] synonym: "upregulation of gluconeogenesis" EXACT [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010907 ! positive regulation of glucose metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006094 ! positively regulates gluconeogenesis relationship: RO:0002213 GO:0006094 ! positively regulates gluconeogenesis [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060271 ! positively regulates cilium assembly relationship: RO:0002213 GO:0060271 ! positively regulates cilium assembly property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045725 name: positive regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "activation of glycogen biosynthetic process" NARROW [] synonym: "positive regulation of glycogen anabolism" EXACT [] synonym: "positive regulation of glycogen biosynthesis" EXACT [] synonym: "positive regulation of glycogen formation" EXACT [] synonym: "positive regulation of glycogen synthesis" EXACT [] synonym: "stimulation of glycogen biosynthetic process" NARROW [] synonym: "up regulation of glycogen biosynthetic process" EXACT [] synonym: "up-regulation of glycogen biosynthetic process" EXACT [] synonym: "upregulation of glycogen biosynthetic process" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005978 ! positively regulates glycogen biosynthetic process relationship: RO:0002213 GO:0005978 ! positively regulates glycogen biosynthetic process [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process alt_id: GO:0045946 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006412 ! positively regulates translation relationship: RO:0002213 GO:0006412 ! positively regulates translation [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process alt_id: GO:1903364 alt_id: GO:2000600 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process" EXACT [] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "positive regulation of cyclin catabolic process" NARROW [] synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030163 ! positively regulates protein catabolic process relationship: RO:0002213 GO:0030163 ! positively regulates protein catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0045733 name: acetate catabolic process namespace: biological_process alt_id: GO:0019663 def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate breakdown" EXACT [] synonym: "acetate catabolism" EXACT [] synonym: "acetate degradation" EXACT [] synonym: "homoacetate catabolic process" RELATED [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate relationship: RO:0004009 CHEBI:30089 ! has primary input acetate [Term] id: GO:0045734 name: regulation of acetate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "regulation of acetate breakdown" EXACT [] synonym: "regulation of acetate catabolism" EXACT [] synonym: "regulation of acetate degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045733 ! regulates acetate catabolic process relationship: RO:0002211 GO:0045733 ! regulates acetate catabolic process [Term] id: GO:0045753 name: negative regulation of acetate catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "down regulation of acetate catabolic process" EXACT [] synonym: "down-regulation of acetate catabolic process" EXACT [] synonym: "downregulation of acetate catabolic process" EXACT [] synonym: "inhibition of acetate catabolic process" NARROW [] synonym: "negative regulation of acetate breakdown" EXACT [] synonym: "negative regulation of acetate catabolism" EXACT [] synonym: "negative regulation of acetate degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045733 ! negatively regulates acetate catabolic process relationship: RO:0002212 GO:0045733 ! negatively regulates acetate catabolic process [Term] id: GO:0045754 name: positive regulation of acetate catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "activation of acetate catabolic process" NARROW [] synonym: "positive regulation of acetate breakdown" EXACT [] synonym: "positive regulation of acetate catabolism" EXACT [] synonym: "positive regulation of acetate degradation" EXACT [] synonym: "stimulation of acetate catabolic process" NARROW [] synonym: "up regulation of acetate catabolic process" EXACT [] synonym: "up-regulation of acetate catabolic process" EXACT [] synonym: "upregulation of acetate catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045733 ! positively regulates acetate catabolic process relationship: RO:0002213 GO:0045733 ! positively regulates acetate catabolic process [Term] id: GO:0045759 name: negative regulation of action potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "down regulation of action potential" EXACT [] synonym: "down-regulation of action potential" EXACT [] synonym: "downregulation of action potential" EXACT [] synonym: "inhibition of action potential" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001508 ! negatively regulates action potential relationship: RO:0002212 GO:0001508 ! negatively regulates action potential [Term] id: GO:0045760 name: positive regulation of action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "activation of action potential" NARROW [] synonym: "stimulation of action potential" NARROW [] synonym: "up regulation of action potential" EXACT [] synonym: "up-regulation of action potential" EXACT [] synonym: "upregulation of action potential" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001508 ! positively regulates action potential relationship: RO:0002213 GO:0001508 ! positively regulates action potential [Term] id: GO:0045763 name: negative regulation of amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process relationship: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0045764 name: positive regulation of amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "positive regulation of cellular amino acid metabolic process" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process relationship: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001525 ! regulates angiogenesis relationship: RO:0002211 GO:0001525 ! regulates angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001525 ! positively regulates angiogenesis relationship: RO:0002213 GO:0001525 ! positively regulates angiogenesis [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division relationship: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division relationship: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division [Term] id: GO:0045778 name: positive regulation of ossification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "activation of ossification" NARROW [] synonym: "positive regulation of bone biosynthesis" EXACT [] synonym: "positive regulation of bone formation" EXACT [] synonym: "stimulation of ossification" NARROW [] synonym: "up regulation of ossification" EXACT [] synonym: "up-regulation of ossification" EXACT [] synonym: "upregulation of ossification" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001503 ! positively regulates ossification relationship: RO:0002213 GO:0001503 ! positively regulates ossification [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-193670 "p75NTR negatively regulates cell cycle via SC1" is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007049 ! negatively regulates cell cycle relationship: RO:0002212 GO:0007049 ! negatively regulates cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-8849470 "PTK6 Regulates Cell Cycle" is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007049 ! positively regulates cell cycle relationship: RO:0002213 GO:0007049 ! positively regulates cell cycle [Term] id: GO:0045818 name: negative regulation of glycogen catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen catabolic process" EXACT [] synonym: "down-regulation of glycogen catabolic process" EXACT [] synonym: "downregulation of glycogen catabolic process" EXACT [] synonym: "inhibition of glycogen catabolic process" NARROW [] synonym: "negative regulation of glycogen breakdown" EXACT [] synonym: "negative regulation of glycogen catabolism" EXACT [] synonym: "negative regulation of glycogen degradation" EXACT [] synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005980 ! negatively regulates glycogen catabolic process relationship: RO:0002212 GO:0005980 ! negatively regulates glycogen catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29024 xsd:anyURI [Term] id: GO:0045819 name: positive regulation of glycogen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "activation of glycogen catabolic process" NARROW [] synonym: "positive regulation of glycogen breakdown" EXACT [] synonym: "positive regulation of glycogen catabolism" EXACT [] synonym: "positive regulation of glycogen degradation" EXACT [] synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl] synonym: "stimulation of glycogen catabolic process" NARROW [] synonym: "up regulation of glycogen catabolic process" EXACT [] synonym: "up-regulation of glycogen catabolic process" EXACT [] synonym: "upregulation of glycogen catabolic process" EXACT [] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005980 ! positively regulates glycogen catabolic process relationship: RO:0002213 GO:0005980 ! positively regulates glycogen catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29024 xsd:anyURI [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060047 ! negatively regulates heart contraction relationship: RO:0002212 GO:0060047 ! negatively regulates heart contraction [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060047 ! positively regulates heart contraction relationship: RO:0002213 GO:0060047 ! positively regulates heart contraction [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process relationship: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process relationship: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division relationship: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division relationship: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division relationship: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division relationship: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division [Term] id: GO:0045843 name: negative regulation of striated muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "down regulation of striated muscle development" EXACT [] synonym: "down-regulation of striated muscle development" EXACT [] synonym: "downregulation of striated muscle development" EXACT [] synonym: "inhibition of striated muscle development" NARROW [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048635 ! negative regulation of muscle organ development is_a: GO:1901862 ! negative regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development relationship: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development [Term] id: GO:0045844 name: positive regulation of striated muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "activation of striated muscle development" NARROW [] synonym: "stimulation of striated muscle development" NARROW [] synonym: "up regulation of striated muscle development" EXACT [] synonym: "up-regulation of striated muscle development" EXACT [] synonym: "upregulation of striated muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048636 ! positive regulation of muscle organ development is_a: GO:1901863 ! positive regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development relationship: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006414 ! negatively regulates translational elongation relationship: RO:0002212 GO:0006414 ! negatively regulates translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006414 ! positively regulates translational elongation relationship: RO:0002213 GO:0006414 ! positively regulates translational elongation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006415 ! negatively regulates translational termination relationship: RO:0002212 GO:0006415 ! negatively regulates translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006415 ! positively regulates translational termination relationship: RO:0002213 GO:0006415 ! positively regulates translational termination [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process relationship: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process relationship: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process [Term] id: GO:0045914 name: negative regulation of catecholamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "down regulation of catecholamine metabolic process" EXACT [] synonym: "down-regulation of catecholamine metabolic process" EXACT [] synonym: "downregulation of catecholamine metabolic process" EXACT [] synonym: "inhibition of catecholamine metabolic process" NARROW [] synonym: "negative regulation of catecholamine metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006584 ! negatively regulates catecholamine metabolic process relationship: RO:0002212 GO:0006584 ! negatively regulates catecholamine metabolic process [Term] id: GO:0045915 name: positive regulation of catecholamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "activation of catecholamine metabolic process" NARROW [] synonym: "positive regulation of catecholamine metabolism" EXACT [] synonym: "stimulation of catecholamine metabolic process" NARROW [] synonym: "up regulation of catecholamine metabolic process" EXACT [] synonym: "up-regulation of catecholamine metabolic process" EXACT [] synonym: "upregulation of catecholamine metabolic process" EXACT [] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006584 ! positively regulates catecholamine metabolic process relationship: RO:0002213 GO:0006584 ! positively regulates catecholamine metabolic process [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006887 ! negatively regulates exocytosis relationship: RO:0002212 GO:0006887 ! negatively regulates exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006887 ! positively regulates exocytosis relationship: RO:0002213 GO:0006887 ! positively regulates exocytosis [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040007 ! negatively regulates growth relationship: RO:0002212 GO:0040007 ! negatively regulates growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040007 ! positively regulates growth relationship: RO:0002213 GO:0040007 ! positively regulates growth [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-8854050 "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle relationship: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle relationship: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle [Term] id: GO:0045932 name: negative regulation of muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "down regulation of muscle contraction" EXACT [] synonym: "down-regulation of muscle contraction" EXACT [] synonym: "downregulation of muscle contraction" EXACT [] synonym: "inhibition of muscle contraction" NARROW [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006936 ! negatively regulates muscle contraction relationship: RO:0002212 GO:0006936 ! negatively regulates muscle contraction [Term] id: GO:0045933 name: positive regulation of muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "activation of muscle contraction" NARROW [] synonym: "stimulation of muscle contraction" NARROW [] synonym: "up regulation of muscle contraction" EXACT [] synonym: "up-regulation of muscle contraction" EXACT [] synonym: "upregulation of muscle contraction" EXACT [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006936 ! positively regulates muscle contraction relationship: RO:0002213 GO:0006936 ! positively regulates muscle contraction [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process relationship: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006139 ! positively regulates nucleobase-containing compound metabolic process relationship: RO:0002213 GO:0006139 ! positively regulates nucleobase-containing compound metabolic process [Term] id: GO:0045939 name: negative regulation of steroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "down regulation of steroid metabolic process" EXACT [] synonym: "down-regulation of steroid metabolic process" EXACT [] synonym: "downregulation of steroid metabolic process" EXACT [] synonym: "inhibition of steroid metabolic process" NARROW [] synonym: "negative regulation of steroid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process relationship: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process [Term] id: GO:0045940 name: positive regulation of steroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "activation of steroid metabolic process" NARROW [] synonym: "positive regulation of steroid metabolism" EXACT [] synonym: "stimulation of steroid metabolic process" NARROW [] synonym: "up regulation of steroid metabolic process" EXACT [] synonym: "up-regulation of steroid metabolic process" EXACT [] synonym: "upregulation of steroid metabolic process" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process relationship: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: RO:0002212 GO:0006413 ! negatively regulates translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: RO:0002213 GO:0006413 ! positively regulates translational initiation [Term] id: GO:0045986 name: negative regulation of smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of smooth muscle contraction" EXACT [] synonym: "down-regulation of smooth muscle contraction" EXACT [] synonym: "downregulation of smooth muscle contraction" EXACT [] synonym: "inhibition of smooth muscle contraction" NARROW [] synonym: "smooth muscle relaxation" RELATED [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction relationship: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction [Term] id: GO:0045987 name: positive regulation of smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "activation of smooth muscle contraction" NARROW [] synonym: "stimulation of smooth muscle contraction" NARROW [] synonym: "up regulation of smooth muscle contraction" EXACT [] synonym: "up-regulation of smooth muscle contraction" EXACT [] synonym: "upregulation of smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction relationship: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction [Term] id: GO:0045988 name: negative regulation of striated muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "down regulation of striated muscle contraction" EXACT [] synonym: "down-regulation of striated muscle contraction" EXACT [] synonym: "downregulation of striated muscle contraction" EXACT [] synonym: "inhibition of striated muscle contraction" NARROW [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction relationship: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction [Term] id: GO:0045989 name: positive regulation of striated muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "activation of striated muscle contraction" NARROW [] synonym: "stimulation of striated muscle contraction" NARROW [] synonym: "up regulation of striated muscle contraction" EXACT [] synonym: "up-regulation of striated muscle contraction" EXACT [] synonym: "upregulation of striated muscle contraction" EXACT [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction relationship: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009790 ! negatively regulates embryo development relationship: RO:0002212 GO:0009790 ! negatively regulates embryo development [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009790 ! regulates embryo development relationship: RO:0002211 GO:0009790 ! regulates embryo development [Term] id: GO:0046112 name: nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0009112 ! nucleobase metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18282 ! has primary output nucleobase relationship: RO:0004008 CHEBI:18282 ! has primary output nucleobase [Term] id: GO:0046113 name: nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase breakdown" EXACT [] synonym: "nucleobase catabolism" EXACT [] synonym: "nucleobase degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009112 ! nucleobase metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase [Term] id: GO:0046189 name: phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai] synonym: "phenol-containing compound anabolism" EXACT [] synonym: "phenol-containing compound biosynthesis" EXACT [] synonym: "phenol-containing compound formation" EXACT [] synonym: "phenol-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33853 ! has primary output phenols relationship: RO:0004008 CHEBI:33853 ! has primary output phenols [Term] id: GO:0046219 name: indolalkylamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] synonym: "indolalkylamine anabolism" EXACT [] synonym: "indolalkylamine biosynthesis" EXACT [] synonym: "indolalkylamine formation" EXACT [] synonym: "indolalkylamine synthesis" EXACT [] xref: Reactome:R-HSA-209931 "Serotonin and melatonin biosynthesis" is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0042401 ! biogenic amine biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:38631 ! has primary output aminoalkylindole relationship: RO:0004008 CHEBI:38631 ! has primary output aminoalkylindole [Term] id: GO:0046364 name: monosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide anabolism" EXACT [] synonym: "monosaccharide biosynthesis" EXACT [] synonym: "monosaccharide formation" EXACT [] synonym: "monosaccharide synthesis" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35381 ! has primary output monosaccharide relationship: RO:0004008 CHEBI:35381 ! has primary output monosaccharide [Term] id: GO:0046365 name: monosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide breakdown" EXACT [] synonym: "monosaccharide catabolism" EXACT [] synonym: "monosaccharide degradation" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35381 ! has primary input monosaccharide relationship: RO:0004009 CHEBI:35381 ! has primary input monosaccharide [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion relationship: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0046466 name: membrane lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid breakdown" EXACT [] synonym: "membrane lipid catabolism" EXACT [] synonym: "membrane lipid degradation" EXACT [] synonym: "membrane lipid peroxidation" BROAD [GOC:tb] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI [Term] id: GO:0046467 name: membrane lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid anabolism" EXACT [] synonym: "membrane lipid biosynthesis" EXACT [] synonym: "membrane lipid formation" EXACT [] synonym: "membrane lipid synthesis" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid [Term] id: GO:0046530 name: photoreceptor cell differentiation namespace: biological_process alt_id: GO:0007467 def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell relationship: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell [Term] id: GO:0046532 name: regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045673 def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation relationship: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation [Term] id: GO:0046533 name: negative regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045674 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "down regulation of photoreceptor cell differentiation" EXACT [] synonym: "down regulation of photoreceptor differentiation" EXACT [] synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] synonym: "down-regulation of photoreceptor differentiation" EXACT [] synonym: "downregulation of photoreceptor cell differentiation" EXACT [] synonym: "downregulation of photoreceptor differentiation" EXACT [] synonym: "inhibition of photoreceptor cell differentiation" NARROW [] synonym: "inhibition of photoreceptor differentiation" NARROW [] synonym: "negative regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation relationship: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation [Term] id: GO:0046534 name: positive regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045675 def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "activation of photoreceptor cell differentiation" NARROW [] synonym: "activation of photoreceptor differentiation" NARROW [] synonym: "positive regulation of photoreceptor differentiation" EXACT [] synonym: "stimulation of photoreceptor cell differentiation" NARROW [] synonym: "stimulation of photoreceptor differentiation" NARROW [] synonym: "up regulation of photoreceptor cell differentiation" EXACT [] synonym: "up regulation of photoreceptor differentiation" EXACT [] synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] synonym: "up-regulation of photoreceptor differentiation" EXACT [] synonym: "upregulation of photoreceptor cell differentiation" EXACT [] synonym: "upregulation of photoreceptor differentiation" EXACT [] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation relationship: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation [Term] id: GO:0046545 name: development of primary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046660 ! female sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046548 name: retinal rod cell development namespace: biological_process def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000604 ! results in development of retinal rod cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060221 ! retinal rod cell differentiation relationship: RO:0002296 CL:0000604 ! results in development of retinal rod cell [Term] id: GO:0046549 name: retinal cone cell development namespace: biological_process def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000573 ! results in development of retinal cone cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0042670 ! retinal cone cell differentiation relationship: RO:0002296 CL:0000573 ! results in development of retinal cone cell [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035265 ! regulates organ growth relationship: RO:0002211 GO:0035265 ! regulates organ growth [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035265 ! negatively regulates organ growth relationship: RO:0002212 GO:0035265 ! negatively regulates organ growth [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035265 ! positively regulates organ growth relationship: RO:0002213 GO:0035265 ! positively regulates organ growth [Term] id: GO:0046660 name: female sex differentiation namespace: biological_process def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007275 ! multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046666 name: retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the developing retina." [GOC:bf] synonym: "programmed cell death, retina cells" EXACT [] synonym: "programmed cell death, retinal cells" EXACT [] synonym: "retina cell programmed cell death" EXACT [] synonym: "retina programmed cell death" EXACT [] synonym: "retinal programmed cell death" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0046667 name: compound eye retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] is_a: GO:0046666 ! retinal cell programmed cell death intersection_of: GO:0046666 ! retinal cell programmed cell death intersection_of: RO:0002299 UBERON:0000018 ! results in maturation of compound eye relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0001745 ! compound eye morphogenesis relationship: RO:0002299 UBERON:0000018 ! results in maturation of compound eye [Term] id: GO:0046668 name: regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death relationship: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death [Term] id: GO:0046669 name: regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046668 ! regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death relationship: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death [Term] id: GO:0046670 name: positive regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "activation of retinal programmed cell death" NARROW [] synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] synonym: "stimulation of retinal programmed cell death" NARROW [] synonym: "up regulation of retinal programmed cell death" EXACT [] synonym: "up-regulation of retinal programmed cell death" EXACT [] synonym: "upregulation of retinal programmed cell death" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death relationship: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death [Term] id: GO:0046671 name: negative regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "down regulation of retinal programmed cell death" EXACT [] synonym: "down-regulation of retinal programmed cell death" EXACT [] synonym: "downregulation of retinal programmed cell death" EXACT [] synonym: "inhibition of retinal programmed cell death" NARROW [] synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death relationship: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death [Term] id: GO:0046672 name: positive regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "activation of retinal cell programmed cell death" BROAD [] synonym: "positive regulation of retinal cell programmed cell death" BROAD [] synonym: "stimulation of retinal cell programmed cell death" BROAD [] synonym: "up regulation of retinal cell programmed cell death" BROAD [] synonym: "up-regulation of retinal cell programmed cell death" BROAD [] synonym: "upregulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death relationship: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046673 name: negative regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "down regulation of retinal cell programmed cell death" BROAD [] synonym: "down-regulation of retinal cell programmed cell death" BROAD [] synonym: "downregulation of retinal cell programmed cell death" BROAD [] synonym: "inhibition of retinal cell programmed cell death" BROAD [] synonym: "negative regulation of retina cell programmed cell death" BROAD [] synonym: "negative regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death relationship: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046676 name: negative regulation of insulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] synonym: "down regulation of insulin secretion" EXACT [] synonym: "down-regulation of insulin secretion" EXACT [] synonym: "downregulation of insulin secretion" EXACT [] synonym: "inhibition of insulin secretion" NARROW [] xref: Reactome:R-HSA-400042 "Adrenaline,noradrenaline inhibits insulin secretion" is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030073 ! negatively regulates insulin secretion relationship: RO:0002212 GO:0030073 ! negatively regulates insulin secretion [Term] id: GO:0046681 name: response to carbamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544] synonym: "carbamate resistance" RELATED [] synonym: "carbamate susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:13941 ! has primary input carbamate relationship: RO:0004009 CHEBI:13941 ! has primary input carbamate [Term] id: GO:0046716 name: muscle cell cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] synonym: "muscle homeostasis" RELATED [GOC:dph] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24218 xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0046717 name: acid secretion namespace: biological_process def: "The controlled release of acid by a cell or a tissue." [GOC:ai] is_a: GO:0046903 ! secretion [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] synonym: "microtubule assembly" EXACT [] synonym: "microtubule formation" RELATED [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005874 ! results in assembly of microtubule relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002588 GO:0005874 ! results in assembly of microtubule relationship: starts_with GO:0007020 ! microtubule nucleation [Term] id: GO:0046873 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25213 ! has primary input metal cation relationship: part_of GO:0030001 ! metal ion transport relationship: RO:0004009 CHEBI:25213 ! has primary input metal cation [Term] id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046883 name: regulation of hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0023051 ! regulation of signaling is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046879 ! regulates hormone secretion relationship: RO:0002211 GO:0046879 ! regulates hormone secretion [Term] id: GO:0046887 name: positive regulation of hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "activation of hormone secretion" NARROW [] synonym: "stimulation of hormone secretion" NARROW [] synonym: "up regulation of hormone secretion" EXACT [] synonym: "up-regulation of hormone secretion" EXACT [] synonym: "upregulation of hormone secretion" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046879 ! positively regulates hormone secretion relationship: RO:0002213 GO:0046879 ! positively regulates hormone secretion [Term] id: GO:0046888 name: negative regulation of hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "down regulation of hormone secretion" EXACT [] synonym: "down-regulation of hormone secretion" EXACT [] synonym: "downregulation of hormone secretion" EXACT [] synonym: "inhibition of hormone secretion" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046879 ! negatively regulates hormone secretion relationship: RO:0002212 GO:0046879 ! negatively regulates hormone secretion [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process relationship: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process relationship: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046928 name: regulation of neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion relationship: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion [Term] id: GO:0046929 name: negative regulation of neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] synonym: "conotoxin activity" NARROW [] synonym: "down regulation of neurotransmitter secretion" EXACT [] synonym: "down-regulation of neurotransmitter secretion" EXACT [] synonym: "downregulation of neurotransmitter secretion" EXACT [] synonym: "inhibition of neurotransmitter secretion" NARROW [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion relationship: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0047496 name: vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0048048 name: embryonic eye morphogenesis namespace: biological_process def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048066 name: developmental pigmentation namespace: biological_process def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] synonym: "pigmentation during development" RELATED [] is_a: GO:0043473 ! pigmentation [Term] id: GO:0048070 name: regulation of developmental pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] is_a: GO:0120305 ! regulation of pigmentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048066 ! regulates developmental pigmentation relationship: RO:0002211 GO:0048066 ! regulates developmental pigmentation [Term] id: GO:0048086 name: negative regulation of developmental pigmentation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of pigmentation" NARROW [] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation relationship: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation [Term] id: GO:0048087 name: positive regulation of developmental pigmentation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation relationship: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000723 ! has primary input somatic stem cell relationship: RO:0004009 CL:0000723 ! has primary input somatic stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048132 name: female germ-line stem cell asymmetric division namespace: biological_process alt_id: GO:0048141 def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] synonym: "female germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000022 ! has primary input female germ line stem cell relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0048477 ! oogenesis relationship: RO:0004009 CL:0000022 ! has primary input female germ line stem cell [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000057 ! acts on population of fibroblast relationship: RO:0012003 CL:0000057 ! acts on population of fibroblast property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048144 ! regulates fibroblast proliferation relationship: RO:0002211 GO:0048144 ! regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation relationship: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation relationship: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle relationship: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting intersection_of: GO:0006903 ! vesicle targeting intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus intersection_of: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle relationship: part_of GO:0048193 ! Golgi vesicle transport relationship: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus relationship: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi relationship: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi [Term] id: GO:0048243 name: norepinephrine secretion namespace: biological_process def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] synonym: "noradrenaline secretion" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) [Term] id: GO:0048251 name: elastic fiber assembly namespace: biological_process def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] synonym: "elastic fibre assembly" EXACT [] synonym: "elastin fiber assembly" EXACT [GOC:BHF] synonym: "elastin fibre assembly" EXACT [GOC:BHF] is_a: GO:0085029 ! extracellular matrix assembly is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0071953 ! results in assembly of elastic fiber relationship: RO:0002588 GO:0071953 ! results in assembly of elastic fiber [Term] id: GO:0048280 name: vesicle fusion with Golgi apparatus namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] is_a: GO:0006906 ! vesicle fusion is_a: GO:0007030 ! Golgi organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: part_of GO:0048193 ! Golgi vesicle transport relationship: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0043226 ! results in fusion of organelle relationship: RO:0012008 GO:0043226 ! results in fusion of organelle [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fission_of GO:0043226 ! organelle relationship: results_in_fission_of GO:0043226 ! organelle [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion intersection_of: GO:0000740 ! nuclear membrane fusion intersection_of: part_of GO:0000741 ! karyogamy relationship: part_of GO:0000741 ! karyogamy [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048313 name: Golgi inheritance namespace: biological_process def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] synonym: "Golgi apparatus inheritance" EXACT [] synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi partitioning" EXACT [] xref: Reactome:R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" is_a: GO:0007030 ! Golgi organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005794 ! Golgi apparatus relationship: results_in_distribution_of GO:0005794 ! Golgi apparatus [Term] id: GO:0048318 name: axial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm [Term] id: GO:0048319 name: axial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0048318 ! axial mesoderm development relationship: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm [Term] id: GO:0048320 name: axial mesoderm formation namespace: biological_process def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9796292 "Formation of axial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003068 ! results in formation of anatomical entity axial mesoderm relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0048319 ! axial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003068 ! results in formation of anatomical entity axial mesoderm [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007498 ! mesoderm development relationship: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm [Term] id: GO:0048333 name: mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] synonym: "mesoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0001707 ! mesoderm formation relationship: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell [Term] id: GO:0048339 name: paraxial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm [Term] id: GO:0048340 name: paraxial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0048339 ! paraxial mesoderm development relationship: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm [Term] id: GO:0048341 name: paraxial mesoderm formation namespace: biological_process def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9793380 "Formation of paraxial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003077 ! results in formation of anatomical entity paraxial mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003077 ! results in formation of anatomical entity paraxial mesoderm [Term] id: GO:0048368 name: lateral mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] synonym: "lateral plate mesoderm development" EXACT [] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm [Term] id: GO:0048369 name: lateral mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] synonym: "lateral plate mesoderm morphogenesis" EXACT [] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0048368 ! lateral mesoderm development relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048370 name: lateral mesoderm formation namespace: biological_process def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] synonym: "lateral plate mesoderm biosynthesis" EXACT [] synonym: "lateral plate mesoderm formation" EXACT [] xref: Reactome:R-HSA-9758920 "Formation of lateral plate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048389 name: intermediate mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm relationship: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm [Term] id: GO:0048390 name: intermediate mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm relationship: part_of GO:0048389 ! intermediate mesoderm development relationship: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm [Term] id: GO:0048391 name: intermediate mesoderm formation namespace: biological_process def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9761174 "Formation of intermediate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003064 ! results in formation of anatomical entity intermediate mesoderm relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis relationship: RO:0002297 UBERON:0003064 ! results in formation of anatomical entity intermediate mesoderm [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002296 CL:0000000 ! results in development of cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0030154 ! cell differentiation relationship: RO:0002296 CL:0000000 ! results in development of cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24390 xsd:anyURI [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000000 ! results in maturation of cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0048468 ! cell development relationship: RO:0002299 CL:0000000 ! results in maturation of cell property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24390 xsd:anyURI [Term] id: GO:0048477 name: oogenesis namespace: biological_process alt_id: GO:0009993 alt_id: GO:0048157 def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000025 ! results in development of egg cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002296 CL:0000025 ! results in development of egg cell [Term] id: GO:0048483 name: autonomic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system [Term] id: GO:0048485 name: sympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048483 ! autonomic nervous system development relationship: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system [Term] id: GO:0048505 name: regulation of timing of cell differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of cell differentiation" RELATED [] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0045595 ! regulation of cell differentiation [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25943 xsd:anyURI [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001568 ! blood vessel development relationship: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008150 ! positively regulates biological_process relationship: RO:0002213 GO:0008150 ! positively regulates biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008150 ! negatively regulates biological_process relationship: RO:0002212 GO:0008150 ! negatively regulates biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007610 ! positively regulates behavior relationship: RO:0002213 GO:0007610 ! positively regulates behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007610 ! negatively regulates behavior relationship: RO:0002212 GO:0007610 ! negatively regulates behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009987 ! positively regulates cellular process relationship: RO:0002213 GO:0009987 ! positively regulates cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009987 ! negatively regulates cellular process relationship: RO:0002212 GO:0009987 ! negatively regulates cellular process [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hemopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! animal organ development relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0002520 ! immune system development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048536 name: spleen development namespace: biological_process def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002106 ! results in development of spleen relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: RO:0002296 UBERON:0002106 ! results in development of spleen [Term] id: GO:0048539 name: bone marrow development namespace: biological_process def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002371 ! results in development of bone marrow relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060348 ! bone development relationship: RO:0002296 UBERON:0002371 ! results in development of bone marrow [Term] id: GO:0048545 name: response to steroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input steroid hormone relationship: RO:0004009 CHEBI:26764 ! has primary input steroid hormone property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048546 name: digestive tract morphogenesis namespace: biological_process alt_id: GO:0048547 def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] synonym: "alimentary canal morphogenesis" EXACT [] synonym: "digestive tube morphogenesis" EXACT [] synonym: "gastrointestinal tract morphogenesis" EXACT [] synonym: "gut morphogenesis" BROAD [GOC:dph] synonym: "intestinal morphogenesis" NARROW [] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0048565 name: digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "gut development" BROAD [GOC:dph] synonym: "intestinal development" NARROW [] synonym: "intestine development" NARROW [] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001555 ! results in development of digestive tract relationship: part_of GO:0055123 ! digestive system development relationship: RO:0002296 UBERON:0001555 ! results in development of digestive tract [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: part_of GO:0009790 ! embryo development intersection_of: RO:0002296 UBERON:0000062 ! results in development of organ relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0009790 ! embryo development relationship: RO:0002296 UBERON:0000062 ! results in development of organ property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0030903 ! notochord development relationship: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord [Term] id: GO:0048580 name: regulation of post-embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009791 ! regulates post-embryonic development relationship: RO:0002211 GO:0009791 ! regulates post-embryonic development [Term] id: GO:0048581 name: negative regulation of post-embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "down regulation of post-embryonic development" EXACT [] synonym: "down-regulation of post-embryonic development" EXACT [] synonym: "downregulation of post-embryonic development" EXACT [] synonym: "inhibition of post-embryonic development" NARROW [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development relationship: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development [Term] id: GO:0048582 name: positive regulation of post-embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "activation of post-embryonic development" NARROW [] synonym: "stimulation of post-embryonic development" NARROW [] synonym: "up regulation of post-embryonic development" EXACT [] synonym: "up-regulation of post-embryonic development" EXACT [] synonym: "upregulation of post-embryonic development" EXACT [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009791 ! positively regulates post-embryonic development relationship: RO:0002213 GO:0009791 ! positively regulates post-embryonic development [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050896 ! regulates response to stimulus relationship: RO:0002211 GO:0050896 ! regulates response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050896 ! positively regulates response to stimulus relationship: RO:0002213 GO:0050896 ! positively regulates response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050896 ! negatively regulates response to stimulus relationship: RO:0002212 GO:0050896 ! negatively regulates response to stimulus [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] subset: gocheck_do_not_annotate synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048468 ! cell development property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0032502 ! developmental process relationship: part_of GO:0032502 ! developmental process [Term] id: GO:0048592 name: eye morphogenesis namespace: biological_process alt_id: GO:0048748 def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye relationship: part_of GO:0001654 ! eye development relationship: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye [Term] id: GO:0048593 name: camera-type eye morphogenesis namespace: biological_process alt_id: GO:0048594 alt_id: GO:0048595 def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0043010 ! camera-type eye development relationship: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye [Term] id: GO:0048596 name: embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic eye morphogenesis" BROAD [] is_a: GO:0048048 ! embryonic eye morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031076 ! embryonic camera-type eye development relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process alt_id: GO:0048828 def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0009790 ! embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000023 ! results in development of oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0009994 ! oocyte differentiation relationship: RO:0002296 CL:0000023 ! results in development of oocyte [Term] id: GO:0048601 name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0061458 ! reproductive system development property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23445 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] subset: gocheck_do_not_annotate subset: goslim_drosophila synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] xref: Reactome:R-HSA-1474165 "Reproduction" is_a: GO:0022414 ! reproductive process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27054 xsd:anyURI [Term] id: GO:0048627 name: myoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000056 ! results in development of myoblast relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0045445 ! myoblast differentiation relationship: RO:0002296 CL:0000056 ! results in development of myoblast [Term] id: GO:0048628 name: myoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000056 ! results in maturation of myoblast relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048627 ! myoblast development relationship: RO:0002299 CL:0000056 ! results in maturation of myoblast [Term] id: GO:0048630 name: skeletal muscle tissue growth namespace: biological_process def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007519 ! skeletal muscle tissue development relationship: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue [Term] id: GO:0048631 name: regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth relationship: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth [Term] id: GO:0048632 name: negative regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "down regulation of skeletal muscle growth" EXACT [] synonym: "down-regulation of skeletal muscle growth" EXACT [] synonym: "downregulation of skeletal muscle growth" EXACT [] synonym: "inhibition of skeletal muscle growth" NARROW [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048640 ! negative regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth relationship: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth [Term] id: GO:0048633 name: positive regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "activation of skeletal muscle growth" NARROW [] synonym: "stimulation of skeletal muscle growth" NARROW [] synonym: "up regulation of skeletal muscle growth" EXACT [] synonym: "up-regulation of skeletal muscle growth" EXACT [] synonym: "upregulation of skeletal muscle growth" EXACT [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth relationship: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth [Term] id: GO:0048634 name: regulation of muscle organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007517 ! regulates muscle organ development relationship: RO:0002211 GO:0007517 ! regulates muscle organ development [Term] id: GO:0048635 name: negative regulation of muscle organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] synonym: "down regulation of muscle development" EXACT [] synonym: "down-regulation of muscle development" EXACT [] synonym: "downregulation of muscle development" EXACT [] synonym: "inhibition of muscle development" NARROW [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007517 ! negatively regulates muscle organ development relationship: RO:0002212 GO:0007517 ! negatively regulates muscle organ development [Term] id: GO:0048636 name: positive regulation of muscle organ development namespace: biological_process def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] synonym: "activation of muscle development" NARROW [] synonym: "stimulation of muscle development" NARROW [] synonym: "up regulation of muscle development" EXACT [] synonym: "up-regulation of muscle development" EXACT [] synonym: "upregulation of muscle development" EXACT [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007517 ! positively regulates muscle organ development relationship: RO:0002213 GO:0007517 ! positively regulates muscle organ development [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048589 ! regulates developmental growth relationship: RO:0002211 GO:0048589 ! regulates developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048589 ! positively regulates developmental growth relationship: RO:0002213 GO:0048589 ! positively regulates developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048589 ! negatively regulates developmental growth relationship: RO:0002212 GO:0048589 ! negatively regulates developmental growth [Term] id: GO:0048641 name: regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development relationship: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development [Term] id: GO:0048642 name: negative regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] synonym: "down regulation of skeletal muscle development" EXACT [] synonym: "down-regulation of skeletal muscle development" EXACT [] synonym: "downregulation of skeletal muscle development" EXACT [] synonym: "inhibition of skeletal muscle development" NARROW [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development relationship: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development [Term] id: GO:0048643 name: positive regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] synonym: "activation of skeletal muscle development" NARROW [] synonym: "stimulation of skeletal muscle development" NARROW [] synonym: "up regulation of skeletal muscle development" EXACT [] synonym: "up-regulation of skeletal muscle development" EXACT [] synonym: "upregulation of skeletal muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development relationship: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development [Term] id: GO:0048644 name: muscle organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ relationship: part_of GO:0007517 ! muscle organ development relationship: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ [Term] id: GO:0048645 name: animal organ formation namespace: biological_process def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] synonym: "animal organ primordium initiation" NARROW [] synonym: "initiation of an animal organ primordium" NARROW [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003103 ! results in formation of anatomical entity compound organ relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0009887 ! animal organ morphogenesis relationship: RO:0002297 UBERON:0003103 ! results in formation of anatomical entity compound organ [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048659 name: smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] synonym: "SMC proliferation" EXACT [] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell relationship: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048660 name: regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "regulation of SMC proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation relationship: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048661 name: positive regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "activation of smooth muscle cell proliferation" NARROW [] synonym: "positive regulation of SMC proliferation" EXACT [] synonym: "stimulation of smooth muscle cell proliferation" NARROW [] synonym: "up regulation of smooth muscle cell proliferation" EXACT [] synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] synonym: "upregulation of smooth muscle cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation relationship: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048662 name: negative regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "down regulation of smooth muscle cell proliferation" EXACT [] synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] synonym: "downregulation of smooth muscle cell proliferation" EXACT [] synonym: "inhibition of smooth muscle cell proliferation" NARROW [] synonym: "negative regulation of SMC proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation relationship: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000540 ! results in development of neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030182 ! neuron differentiation relationship: RO:0002296 CL:0000540 ! results in development of neuron [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0030182 ! neuron differentiation relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048705 name: skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0001501 ! skeletal system development relationship: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0009888 ! tissue development relationship: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0048730 name: epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0008544 ! epidermis development relationship: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000467 ! results in development of anatomical system relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0007275 ! multicellular organism development relationship: RO:0002296 UBERON:0000467 ! results in development of anatomical system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048732 name: gland development namespace: biological_process def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002530 ! results in development of gland relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0002530 ! results in development of gland [Term] id: GO:0048736 name: appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000026 ! results in development of appendage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007275 ! multicellular organism development relationship: RO:0002296 UBERON:0000026 ! results in development of appendage [Term] id: GO:0048738 name: cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "heart muscle development" EXACT [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue [Term] id: GO:0048741 name: skeletal muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "skeletal muscle fibre development" EXACT [] synonym: "skeletal myofiber development" EXACT [] synonym: "skeletal myofibre development" EXACT [] is_a: GO:0014904 ! myotube cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007519 ! skeletal muscle tissue development relationship: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber [Term] id: GO:0048742 name: regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] synonym: "regulation of skeletal muscle fibre development" EXACT [] synonym: "regulation of skeletal myofiber development" EXACT [] synonym: "regulation of skeletal myofibre development" EXACT [] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development relationship: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development [Term] id: GO:0048743 name: positive regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "activation of skeletal muscle fiber development" NARROW [] synonym: "positive regulation of skeletal muscle fibre development" EXACT [] synonym: "positive regulation of skeletal myofiber development" EXACT [] synonym: "positive regulation of skeletal myofibre development" EXACT [] synonym: "stimulation of skeletal muscle fiber development" NARROW [] synonym: "up regulation of skeletal muscle fiber development" EXACT [] synonym: "up-regulation of skeletal muscle fiber development" EXACT [] synonym: "upregulation of skeletal muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development relationship: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development [Term] id: GO:0048744 name: negative regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "down regulation of skeletal muscle fiber development" EXACT [] synonym: "down-regulation of skeletal muscle fiber development" EXACT [] synonym: "downregulation of skeletal muscle fiber development" EXACT [] synonym: "inhibition of skeletal muscle fiber development" NARROW [] synonym: "negative regulation of skeletal muscle fibre development" EXACT [] synonym: "negative regulation of skeletal myofiber development" EXACT [] synonym: "negative regulation of skeletal myofibre development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development relationship: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development [Term] id: GO:0048745 name: smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue relationship: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue [Term] id: GO:0048749 name: compound eye development namespace: biological_process alt_id: GO:0007456 def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] synonym: "insect-type retina development" EXACT [PMID:11735386] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000018 ! results in development of compound eye relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: RO:0002296 UBERON:0000018 ! results in development of compound eye [Term] id: GO:0048753 name: pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] subset: goslim_pir synonym: "pigment granule organisation" EXACT [] synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0048770 ! results in organization of pigment granule relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0033059 ! cellular pigmentation relationship: RO:0002592 GO:0048770 ! results in organization of pigment granule [Term] id: GO:0048754 name: branching morphogenesis of an epithelial tube namespace: biological_process def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: part_of GO:0060562 ! epithelial tube morphogenesis [Term] id: GO:0048755 name: branching morphogenesis of a nerve namespace: biological_process def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001763 ! morphogenesis of a branching structure intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve [Term] id: GO:0048762 name: mesenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0060485 ! mesenchyme development relationship: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell [Term] id: GO:0048770 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0048799 name: animal organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000062 ! results in maturation of organ relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0048513 ! animal organ development relationship: RO:0002299 UBERON:0000062 ! results in maturation of organ [Term] id: GO:0048806 name: genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] synonym: "genital development" EXACT [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0007548 ! sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0031175 ! neuron projection development relationship: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection [Term] id: GO:0048821 name: erythrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol] synonym: "RBC development" EXACT [CL:0000232] synonym: "red blood cell development" EXACT [CL:0000232] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000232 ! results in development of erythrocyte relationship: part_of GO:0030218 ! erythrocyte differentiation relationship: RO:0002296 CL:0000232 ! results in development of erythrocyte [Term] id: GO:0048823 name: nucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "nucleate RBC development" EXACT [CL:0000232] synonym: "nucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation relationship: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte [Term] id: GO:0048844 name: artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] synonym: "arterial morphogenesis" EXACT [] synonym: "arteriogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery relationship: part_of GO:0060840 ! artery development relationship: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery [Term] id: GO:0048845 name: venous blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] synonym: "vein morphogenesis" BROAD [] synonym: "venous morphogenesis" EXACT [] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein relationship: part_of GO:0060841 ! venous blood vessel development relationship: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein [Term] id: GO:0048854 name: brain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007420 ! brain development relationship: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_plant_ribbon synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 UBERON:0000061 ! results in development of anatomical structure relationship: RO:0002296 UBERON:0000061 ! results in development of anatomical structure property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI [Term] id: GO:0048857 name: neural nucleus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000125 ! results in development of neural nucleus relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: RO:0002296 UBERON:0000125 ! results in development of neural nucleus [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0030030 ! cell projection organization intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0000902 ! cell morphogenesis relationship: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection [Term] id: GO:0048859 name: formation of anatomical boundary namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007651 ! results in formation of anatomical entity anatomical junction relationship: RO:0002297 UBERON:0007651 ! results in formation of anatomical entity anatomical junction [Term] id: GO:0048863 name: stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] xref: Wikipedia:Stem_cell_differentiation is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell [Term] id: GO:0048864 name: stem cell development namespace: biological_process def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000034 ! results in development of stem cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048863 ! stem cell differentiation relationship: RO:0002296 CL:0000034 ! results in development of stem cell [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_prokaryote synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0048871 name: multicellular organismal-level homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0042592 ! homeostatic process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0048871 ! multicellular organismal-level homeostasis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24218 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: goslim_drosophila is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of chemical entity relationship: RO:0002332 CHEBI:24431 ! regulates levels of chemical entity [Term] id: GO:0048880 name: sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001032 ! results in development of sensory system relationship: RO:0002296 UBERON:0001032 ! results in development of sensory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048934 name: peripheral nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron relationship: part_of GO:0007422 ! peripheral nervous system development relationship: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron [Term] id: GO:0048935 name: peripheral nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation relationship: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005694 ! has primary input chromosome relationship: RO:0004009 GO:0005694 ! has primary input chromosome [Term] id: GO:0050432 name: catecholamine secretion namespace: biological_process def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine [Term] id: GO:0050433 name: regulation of catecholamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050432 ! regulates catecholamine secretion relationship: RO:0002211 GO:0050432 ! regulates catecholamine secretion [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000066 ! acts on population of epithelial cell relationship: RO:0012003 CL:0000066 ! acts on population of epithelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation relationship: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation relationship: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation relationship: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009306 ! regulates protein secretion relationship: RO:0002211 GO:0009306 ! regulates protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009306 ! negatively regulates protein secretion relationship: RO:0002212 GO:0009306 ! negatively regulates protein secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009306 ! positively regulates protein secretion relationship: RO:0002213 GO:0009306 ! positively regulates protein secretion [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022008 ! regulates neurogenesis relationship: RO:0002211 GO:0022008 ! regulates neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022008 ! negatively regulates neurogenesis relationship: RO:0002212 GO:0022008 ! negatively regulates neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022008 ! positively regulates neurogenesis relationship: RO:0002213 GO:0022008 ! positively regulates neurogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] xref: Reactome:R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006955 ! regulates immune response relationship: RO:0002211 GO:0006955 ! regulates immune response [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006955 ! negatively regulates immune response relationship: RO:0002212 GO:0006955 ! negatively regulates immune response [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006955 ! positively regulates immune response relationship: RO:0002213 GO:0006955 ! positively regulates immune response [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008150 ! regulates biological_process relationship: RO:0002211 GO:0008150 ! regulates biological_process [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032502 ! regulates developmental process relationship: RO:0002211 GO:0032502 ! regulates developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009987 ! regulates cellular process relationship: RO:0002211 GO:0009987 ! regulates cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007610 ! regulates behavior relationship: RO:0002211 GO:0007610 ! regulates behavior [Term] id: GO:0050796 name: regulation of insulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] xref: Reactome:R-HSA-422356 "Regulation of insulin secretion" is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030073 ! regulates insulin secretion relationship: RO:0002211 GO:0030073 ! regulates insulin secretion [Term] id: GO:0050801 name: monoatomic ion homeostasis namespace: biological_process alt_id: GO:2000021 def: "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] synonym: "electrolyte homeostasis" RELATED [] synonym: "ion homeostasis" BROAD [] synonym: "negative regulation of crystal formation" RELATED [] synonym: "regulation of ion homeostasis" RELATED [] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of monoatomic ion relationship: RO:0002332 CHEBI:24867 ! regulates levels of monoatomic ion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24455 xsd:anyURI [Term] id: GO:0050803 name: regulation of synapse structure or activity namespace: biological_process def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] is_a: GO:0065008 ! regulation of biological quality relationship: in_taxon NCBITaxon:6072 ! Eumetazoa [Term] id: GO:0050804 name: modulation of chemical synaptic transmission namespace: biological_process def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] subset: goslim_synapse synonym: "modulation of synaptic transmission" BROAD [] synonym: "regulation of chemical synaptic transmission" EXACT [] synonym: "regulation of synaptic transmission" EXACT [] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0050805 name: negative regulation of synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "down regulation of synaptic transmission" EXACT [] synonym: "down-regulation of synaptic transmission" EXACT [] synonym: "downregulation of synaptic transmission" EXACT [] synonym: "inhibition of synaptic transmission" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission relationship: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission [Term] id: GO:0050806 name: positive regulation of synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "activation of synaptic transmission" NARROW [] synonym: "stimulation of synaptic transmission" NARROW [] synonym: "up regulation of synaptic transmission" EXACT [] synonym: "up-regulation of synaptic transmission" EXACT [] synonym: "upregulation of synaptic transmission" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission relationship: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission [Term] id: GO:0050807 name: regulation of synapse organization namespace: biological_process def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of synapse organisation" EXACT [GOC:mah] synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of synapse structure" EXACT [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050808 ! regulates synapse organization relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0050803 ! regulation of synapse structure or activity relationship: RO:0002211 GO:0050808 ! regulates synapse organization [Term] id: GO:0050808 name: synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] subset: goslim_drosophila subset: goslim_synapse synonym: "synapse development" RELATED [GOC:aruk] synonym: "synapse morphogenesis" RELATED [GOC:BHF] synonym: "synapse organisation" EXACT [] synonym: "synapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0034330 ! cell junction organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0045202 ! results in organization of synapse relationship: RO:0002592 GO:0045202 ! results in organization of synapse [Term] id: GO:0050810 name: regulation of steroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] synonym: "regulation of steroid anabolism" EXACT [] synonym: "regulation of steroid biosynthesis" EXACT [] synonym: "regulation of steroid formation" EXACT [] synonym: "regulation of steroid synthesis" EXACT [] synonym: "regulation of steroidogenesis" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process relationship: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: RO:0000057 UBERON:0001016 ! has participant nervous system relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0000057 UBERON:0001016 ! has participant nervous system property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13824 xsd:anyURI [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050879 name: multicellular organismal movement namespace: biological_process def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050881 name: musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] is_a: GO:0050879 ! multicellular organismal movement is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050886 name: endocrine process namespace: biological_process def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544] subset: goslim_generic subset: goslim_pir synonym: "endocrine physiological process" EXACT [] synonym: "endocrine physiology" EXACT [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] subset: goslim_drosophila xref: Wikipedia:Cognition is_a: GO:0050877 ! nervous system process [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050905 name: neuromuscular process namespace: biological_process def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] synonym: "neuromotor process" EXACT [] synonym: "neuromuscular physiological process" EXACT [] is_a: GO:0050877 ! nervous system process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007601 ! visual perception relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0050931 name: pigment cell differentiation namespace: biological_process alt_id: GO:0043357 alt_id: GO:0043358 def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. synonym: "chromatophore differentiation" EXACT [] synonym: "pigmented cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell relationship: part_of GO:0048066 ! developmental pigmentation relationship: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell [Term] id: GO:0050932 name: regulation of pigment cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050931 ! regulates pigment cell differentiation relationship: RO:0002211 GO:0050931 ! regulates pigment cell differentiation [Term] id: GO:0050941 name: negative regulation of pigment cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "down regulation of pigment cell differentiation" EXACT [] synonym: "down-regulation of pigment cell differentiation" EXACT [] synonym: "downregulation of pigment cell differentiation" EXACT [] synonym: "inhibition of pigment cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation relationship: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation [Term] id: GO:0050942 name: positive regulation of pigment cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "activation of pigment cell differentiation" NARROW [] synonym: "stimulation of pigment cell differentiation" NARROW [] synonym: "up regulation of pigment cell differentiation" EXACT [] synonym: "up-regulation of pigment cell differentiation" EXACT [] synonym: "upregulation of pigment cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation [Term] id: GO:0050952 name: sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050956 name: electroception namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception] synonym: "electroception sense" EXACT [] synonym: "electroceptive sense" EXACT [] xref: Wikipedia:Electroreception is_a: GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0050963 name: detection of electrical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050964 name: detection of electrical stimulus involved in electroception namespace: biological_process def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb] synonym: "electroception, detection of electrical stimulus" EXACT [] synonym: "electroception, sensory detection of electrical stimulus" EXACT [] synonym: "electroception, sensory transduction" EXACT [] synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during electroception" RELATED [] synonym: "sensory transduction of electrical stimulus during electroception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0050956 ! electroception relationship: part_of GO:0050956 ! electroception [Term] id: GO:0050967 name: detection of electrical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb] synonym: "perception of pain, detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during perception of pain" RELATED [] synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050968 name: detection of chemical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "chemical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050975 name: sensory perception of touch namespace: biological_process def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] synonym: "perception of touch" EXACT [] synonym: "tactile sense" EXACT [] synonym: "taction" EXACT [] synonym: "tactition" EXACT [] xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050981 name: detection of electrical stimulus namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016042 ! regulates lipid catabolic process relationship: RO:0002211 GO:0016042 ! regulates lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process relationship: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process relationship: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process alt_id: GO:0045011 def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061572 ! actin filament bundle organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle [Term] id: GO:0051032 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: part_of GO:0050657 ! nucleic acid transport relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid [Term] id: GO:0051033 name: RNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" is_a: GO:0051032 ! nucleic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: part_of GO:0050658 ! RNA transport relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046903 ! regulates secretion relationship: RO:0002211 GO:0046903 ! regulates secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046903 ! positively regulates secretion relationship: RO:0002213 GO:0046903 ! positively regulates secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046903 ! negatively regulates secretion relationship: RO:0002212 GO:0046903 ! negatively regulates secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006810 ! regulates transport relationship: RO:0002211 GO:0006810 ! regulates transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006810 ! positively regulates transport relationship: RO:0002213 GO:0006810 ! positively regulates transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006810 ! negatively regulates transport relationship: RO:0002212 GO:0006810 ! negatively regulates transport [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process relationship: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process [Term] id: GO:0051078 name: meiotic nuclear membrane disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" RELATED [] synonym: "meiotic nuclear envelope catabolism" RELATED [] synonym: "meiotic nuclear envelope degradation" RELATED [] synonym: "meiotic nuclear envelope disassembly" RELATED [] is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051081 name: nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai] synonym: "nuclear envelope breakdown" RELATED [] synonym: "nuclear envelope catabolism" RELATED [] synonym: "nuclear envelope degradation" RELATED [] synonym: "nuclear envelope disassembly" RELATED [] is_a: GO:0030397 ! membrane disassembly is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane relationship: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032502 ! negatively regulates developmental process relationship: RO:0002212 GO:0032502 ! negatively regulates developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032502 ! positively regulates developmental process relationship: RO:0002213 GO:0032502 ! positively regulates developmental process [Term] id: GO:0051119 name: sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sugar/polyol channel activity" NARROW [] xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose" xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016043 ! regulates cellular component organization relationship: RO:0002211 GO:0016043 ! regulates cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016043 ! negatively regulates cellular component organization relationship: RO:0002212 GO:0016043 ! negatively regulates cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016043 ! positively regulates cellular component organization relationship: RO:0002213 GO:0016043 ! positively regulates cellular component organization [Term] id: GO:0051145 name: smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] synonym: "nonstriated muscle cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell relationship: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell relationship: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042692 ! regulates muscle cell differentiation relationship: RO:0002211 GO:0042692 ! regulates muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation relationship: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] xref: Reactome:R-HSA-525793 "Myogenesis" is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation relationship: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation [Term] id: GO:0051150 name: regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation relationship: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation [Term] id: GO:0051151 name: negative regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "down regulation of smooth muscle cell differentiation" EXACT [] synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] synonym: "downregulation of smooth muscle cell differentiation" EXACT [] synonym: "inhibition of smooth muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation relationship: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation [Term] id: GO:0051152 name: positive regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "activation of smooth muscle cell differentiation" NARROW [] synonym: "stimulation of smooth muscle cell differentiation" NARROW [] synonym: "up regulation of smooth muscle cell differentiation" EXACT [] synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] synonym: "upregulation of smooth muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation relationship: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation relationship: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation relationship: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation relationship: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus relationship: RO:0002344 GO:0005634 ! results in transport to from or in nucleus [Term] id: GO:0051175 name: negative regulation of sulfur metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "down regulation of sulfur metabolic process" EXACT [] synonym: "down-regulation of sulfur metabolic process" EXACT [] synonym: "downregulation of sulfur metabolic process" EXACT [] synonym: "inhibition of sulfur metabolic process" NARROW [] synonym: "negative regulation of sulfur metabolism" EXACT [] synonym: "negative regulation of sulphur metabolic process" EXACT [] synonym: "negative regulation of sulphur metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006790 ! negatively regulates sulfur compound metabolic process relationship: RO:0002212 GO:0006790 ! negatively regulates sulfur compound metabolic process [Term] id: GO:0051176 name: positive regulation of sulfur metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "activation of sulfur metabolic process" NARROW [] synonym: "positive regulation of sulfur metabolism" EXACT [] synonym: "positive regulation of sulphur metabolic process" EXACT [] synonym: "positive regulation of sulphur metabolism" EXACT [] synonym: "stimulation of sulfur metabolic process" NARROW [] synonym: "up regulation of sulfur metabolic process" EXACT [] synonym: "up-regulation of sulfur metabolic process" EXACT [] synonym: "upregulation of sulfur metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006790 ! positively regulates sulfur compound metabolic process relationship: RO:0002213 GO:0006790 ! positively regulates sulfur compound metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27052 xsd:anyURI created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051216 name: cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424] synonym: "cartilage biogenesis" EXACT [] synonym: "cartilage biosynthesis" EXACT [] synonym: "cartilage element development" EXACT [] synonym: "cartilage formation" EXACT [] synonym: "cartilage organ development" EXACT [] synonym: "chondrogenesis" EXACT [] xref: Wikipedia:Chondrogenesis is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007844 ! results in development of cartilage element relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0001501 ! skeletal system development relationship: part_of GO:0061448 ! connective tissue development relationship: RO:0002296 UBERON:0007844 ! results in development of cartilage element [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015031 ! positively regulates protein transport relationship: RO:0002213 GO:0015031 ! positively regulates protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015031 ! regulates protein transport relationship: RO:0002211 GO:0015031 ! regulates protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015031 ! negatively regulates protein transport relationship: RO:0002212 GO:0015031 ! negatively regulates protein transport [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24200 xsd:anyURI [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032501 ! regulates multicellular organismal process relationship: RO:0002211 GO:0032501 ! regulates multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process relationship: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process relationship: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process alt_id: GO:0032268 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of cellular protein metabolic process" RELATED [] synonym: "regulation of cellular protein metabolism" RELATED [] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019538 ! regulates protein metabolic process relationship: RO:0002211 GO:0019538 ! regulates protein metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process alt_id: GO:0032270 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolic process" EXACT [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019538 ! positively regulates protein metabolic process relationship: RO:0002213 GO:0019538 ! positively regulates protein metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process alt_id: GO:0032269 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolic process" EXACT [] synonym: "negative regulation of cellular protein metabolism" EXACT [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process relationship: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016070 ! regulates RNA metabolic process relationship: RO:0002211 GO:0016070 ! regulates RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process relationship: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process relationship: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0006323 alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "DNA condensation" EXACT [] synonym: "DNA packaging" NARROW [] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005694 ! results in organization of chromosome relationship: RO:0002592 GO:0005694 ! results in organization of chromosome property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22811 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/4585 xsd:anyURI [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051301 ! regulates cell division relationship: RO:0002211 GO:0051301 ! regulates cell division [Term] id: GO:0051303 name: establishment of chromosome localization namespace: biological_process def: "The directed movement of a chromosome to a specific location." [GOC:ai] synonym: "chromosome positioning" EXACT [] synonym: "establishment of chromosome localisation" EXACT [GOC:mah] is_a: GO:0050000 ! chromosome localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005694 ! has primary input chromosome [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0019953 ! sexual reproduction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24599 xsd:anyURI [Term] id: GO:0051402 name: neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron apoptosis" NARROW [] synonym: "neuron programmed cell death by apoptosis" EXACT [] synonym: "neuronal cell apoptosis" EXACT [] synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0051410 name: detoxification of nitrogen compound namespace: biological_process def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] synonym: "detoxification of nitrogenous compound" EXACT [] synonym: "nitric oxide (NO) detoxification" NARROW [] is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity relationship: part_of GO:1901698 ! response to nitrogen compound relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051321 ! regulates meiotic cell cycle relationship: RO:0002211 GO:0051321 ! regulates meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle relationship: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle relationship: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle [Term] id: GO:0051450 name: myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000056 ! acts on population of myoblast relationship: RO:0012003 CL:0000056 ! acts on population of myoblast property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process alt_id: GO:0042146 def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion is_a: GO:0097576 ! vacuole fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007010 ! regulates cytoskeleton organization relationship: RO:0002211 GO:0007010 ! regulates cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization relationship: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization relationship: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization [Term] id: GO:0051588 name: regulation of neurotransmitter transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006836 ! regulates neurotransmitter transport relationship: RO:0002211 GO:0006836 ! regulates neurotransmitter transport [Term] id: GO:0051589 name: negative regulation of neurotransmitter transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of neurotransmitter transport" EXACT [] synonym: "down-regulation of neurotransmitter transport" EXACT [] synonym: "downregulation of neurotransmitter transport" EXACT [] synonym: "inhibition of neurotransmitter transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport relationship: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport [Term] id: GO:0051590 name: positive regulation of neurotransmitter transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of neurotransmitter transport" NARROW [] synonym: "stimulation of neurotransmitter transport" NARROW [] synonym: "up regulation of neurotransmitter transport" EXACT [] synonym: "up-regulation of neurotransmitter transport" EXACT [] synonym: "upregulation of neurotransmitter transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport [Term] id: GO:0051602 name: response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] synonym: "response to electricity" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051620 name: norepinephrine uptake namespace: biological_process def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "levarterenol reuptake" EXACT [] synonym: "levarterenol uptake" EXACT [] synonym: "noradrenaline reuptake" EXACT [] synonym: "noradrenaline uptake" EXACT [] synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "norepinephrine reuptake" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0090493 ! catecholamine uptake intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) [Term] id: GO:0051621 name: regulation of norepinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] synonym: "regulation of levarterenol uptake" EXACT [] synonym: "regulation of noradrenaline uptake" EXACT [] synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051620 ! regulates norepinephrine uptake relationship: RO:0002211 GO:0051620 ! regulates norepinephrine uptake [Term] id: GO:0051622 name: negative regulation of norepinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "down regulation of norepinephrine uptake" EXACT [] synonym: "down-regulation of norepinephrine uptake" EXACT [] synonym: "downregulation of norepinephrine uptake" EXACT [] synonym: "negative regulation of levarterenol uptake" EXACT [] synonym: "negative regulation of noradrenaline uptake" EXACT [] synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake relationship: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake [Term] id: GO:0051623 name: positive regulation of norepinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "activation of norepinephrine uptake" NARROW [] synonym: "positive regulation of levarterenol uptake" EXACT [] synonym: "positive regulation of noradrenaline uptake" EXACT [] synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of norepinephrine uptake" NARROW [] synonym: "up regulation of norepinephrine uptake" EXACT [] synonym: "up-regulation of norepinephrine uptake" EXACT [] synonym: "upregulation of norepinephrine uptake" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake relationship: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake [Term] id: GO:0051630 name: acetylcholine uptake namespace: biological_process def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0015870 ! acetylcholine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure [Term] id: GO:0051631 name: regulation of acetylcholine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051630 ! regulates acetylcholine uptake relationship: RO:0002211 GO:0051630 ! regulates acetylcholine uptake [Term] id: GO:0051632 name: negative regulation of acetylcholine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "down regulation of acetylcholine uptake" EXACT [] synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake relationship: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake [Term] id: GO:0051633 name: positive regulation of acetylcholine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "activation of acetylcholine uptake" NARROW [] synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of acetylcholine uptake" NARROW [] synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake relationship: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: RO:0004009 GO:0043226 ! has primary input organelle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051645 name: Golgi localization namespace: biological_process def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of Golgi localization" EXACT [] synonym: "Golgi apparatus localization" EXACT [] synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus relationship: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus relationship: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle relationship: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane relationship: RO:0002339 GO:0016020 ! has target end location membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000000 ! has primary input cell relationship: RO:0004009 CL:0000000 ! has primary input cell [Term] id: GO:0051683 name: establishment of Golgi localization namespace: biological_process def: "The directed movement of the Golgi to a specific location." [GOC:ai] synonym: "establishment of Golgi apparatus localization" EXACT [] synonym: "establishment of Golgi body localization" EXACT [] synonym: "establishment of Golgi localisation" EXACT [GOC:mah] is_a: GO:0051645 ! Golgi localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon_Union:0000030 ! has primary input relationship: RO:0004009 NCBITaxon_Union:0000030 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-8953897 "Cellular responses to stimuli" is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 alt_id: GO:0007050 alt_id: GO:0071156 alt_id: GO:0071157 alt_id: GO:0071158 alt_id: GO:0071850 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah] synonym: "cell cycle arrest" NARROW [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "mitotic cell cycle arrest" NARROW [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "negative regulation of cell cycle arrest" NARROW [] synonym: "positive regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: Reactome:R-HSA-156711 "Polo-like kinase mediated events" xref: Reactome:R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007049 ! regulates cell cycle relationship: RO:0002211 GO:0007049 ! regulates cell cycle [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051301 ! positively regulates cell division relationship: RO:0002213 GO:0051301 ! positively regulates cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051301 ! negatively regulates cell division relationship: RO:0002212 GO:0051301 ! negatively regulates cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000280 ! regulates nuclear division relationship: RO:0002211 GO:0000280 ! regulates nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000280 ! negatively regulates nuclear division relationship: RO:0002212 GO:0000280 ! negatively regulates nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000280 ! positively regulates nuclear division relationship: RO:0002213 GO:0000280 ! positively regulates nuclear division [Term] id: GO:0051875 name: pigment granule localization namespace: biological_process def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule relationship: part_of GO:0033059 ! cellular pigmentation relationship: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051890 name: regulation of cardioblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] is_a: GO:1905207 ! regulation of cardiocyte differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010002 ! regulates cardioblast differentiation relationship: RO:0002211 GO:0010002 ! regulates cardioblast differentiation [Term] id: GO:0051891 name: positive regulation of cardioblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "activation of cardioblast differentiation" NARROW [] synonym: "stimulation of cardioblast differentiation" NARROW [] synonym: "up regulation of cardioblast differentiation" EXACT [] synonym: "up-regulation of cardioblast differentiation" EXACT [] synonym: "upregulation of cardioblast differentiation" EXACT [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation relationship: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation [Term] id: GO:0051892 name: negative regulation of cardioblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "down regulation of cardioblast differentiation" EXACT [] synonym: "down-regulation of cardioblast differentiation" EXACT [] synonym: "downregulation of cardioblast differentiation" EXACT [] synonym: "inhibition of cardioblast differentiation" NARROW [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation relationship: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation [Term] id: GO:0051904 name: pigment granule transport namespace: biological_process def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pigment granule translocation" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0051875 ! pigment granule localization is_a: GO:0051905 ! establishment of pigment granule localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051905 name: establishment of pigment granule localization namespace: biological_process def: "The directed movement of a pigment granule to a specific location." [GOC:ai] synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0051875 ! pigment granule localization [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019233 ! regulates sensory perception of pain relationship: RO:0002211 GO:0019233 ! regulates sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007600 ! regulates sensory perception relationship: RO:0002211 GO:0007600 ! regulates sensory perception [Term] id: GO:0051937 name: catecholamine transport namespace: biological_process def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine relationship: RO:0004009 CHEBI:33567 ! has primary input catecholamine [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015837 ! regulates amine transport relationship: RO:0002211 GO:0015837 ! regulates amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015837 ! negatively regulates amine transport relationship: RO:0002212 GO:0015837 ! negatively regulates amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015837 ! positively regulates amine transport relationship: RO:0002213 GO:0015837 ! positively regulates amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006865 ! regulates amino acid transport relationship: RO:0002211 GO:0006865 ! regulates amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006865 ! negatively regulates amino acid transport relationship: RO:0002212 GO:0006865 ! negatively regulates amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006865 ! positively regulates amino acid transport relationship: RO:0002213 GO:0006865 ! positively regulates amino acid transport [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007399 ! regulates nervous system development relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002211 GO:0007399 ! regulates nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007399 ! negatively regulates nervous system development relationship: RO:0002212 GO:0007399 ! negatively regulates nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007399 ! positively regulates nervous system development relationship: RO:0002213 GO:0007399 ! positively regulates nervous system development [Term] id: GO:0051963 name: regulation of synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] subset: goslim_synapse synonym: "regulation of synapse biogenesis" EXACT [] synonym: "regulation of synaptogenesis" EXACT [] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007416 ! regulates synapse assembly relationship: RO:0002211 GO:0007416 ! regulates synapse assembly [Term] id: GO:0051964 name: negative regulation of synapse assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "down regulation of synapse assembly" EXACT [] synonym: "down-regulation of synapse assembly" EXACT [] synonym: "downregulation of synapse assembly" EXACT [] synonym: "inhibition of synapse assembly" NARROW [] synonym: "negative regulation of synapse biogenesis" EXACT [] synonym: "negative regulation of synaptogenesis" EXACT [] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007416 ! negatively regulates synapse assembly relationship: RO:0002212 GO:0007416 ! negatively regulates synapse assembly [Term] id: GO:0051965 name: positive regulation of synapse assembly namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "activation of synapse assembly" NARROW [] synonym: "positive regulation of synapse biogenesis" EXACT [] synonym: "positive regulation of synaptogenesis" EXACT [] synonym: "stimulation of synapse assembly" NARROW [] synonym: "up regulation of synapse assembly" EXACT [] synonym: "up-regulation of synapse assembly" EXACT [] synonym: "upregulation of synapse assembly" EXACT [] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901890 ! positive regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007416 ! positively regulates synapse assembly relationship: RO:0002213 GO:0007416 ! positively regulates synapse assembly [Term] id: GO:0051969 name: regulation of transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse relationship: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse [Term] id: GO:0051970 name: negative regulation of transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "down regulation of transmission of nerve impulse" EXACT [] synonym: "down-regulation of transmission of nerve impulse" EXACT [] synonym: "downregulation of transmission of nerve impulse" EXACT [] synonym: "inhibition of transmission of nerve impulse" NARROW [] synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse relationship: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse [Term] id: GO:0051971 name: positive regulation of transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "activation of transmission of nerve impulse" NARROW [] synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of transmission of nerve impulse" NARROW [] synonym: "up regulation of transmission of nerve impulse" EXACT [] synonym: "up-regulation of transmission of nerve impulse" EXACT [] synonym: "upregulation of transmission of nerve impulse" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse relationship: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007059 ! regulates chromosome segregation relationship: RO:0002211 GO:0007059 ! regulates chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007059 ! positively regulates chromosome segregation relationship: RO:0002213 GO:0007059 ! positively regulates chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation relationship: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation [Term] id: GO:0055001 name: muscle cell development namespace: biological_process alt_id: GO:0048747 def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] synonym: "muscle fiber development" EXACT [] synonym: "muscle fibre development" EXACT [] synonym: "myofiber development" EXACT [] synonym: "myofibre development" EXACT [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000187 ! results in development of muscle cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0042692 ! muscle cell differentiation relationship: RO:0002296 CL:0000187 ! results in development of muscle cell [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000737 ! results in development of striated muscle cell relationship: part_of GO:0051146 ! striated muscle cell differentiation relationship: RO:0002296 CL:0000737 ! results in development of striated muscle cell [Term] id: GO:0055003 name: cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "cardiac myofibril development" EXACT [] synonym: "cardiac myofibril morphogenesis" EXACT [] synonym: "heart myofibril assembly" RELATED [] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0055013 ! cardiac muscle cell development relationship: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril [Term] id: GO:0055006 name: cardiac cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] synonym: "cardiocyte development" EXACT [GOC:dph] synonym: "heart cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002494 ! results in development of cardiocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0035051 ! cardiocyte differentiation relationship: RO:0002296 CL:0002494 ! results in development of cardiocyte [Term] id: GO:0055007 name: cardiac muscle cell differentiation namespace: biological_process def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte differentiation" EXACT [] synonym: "heart muscle cell differentiation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell relationship: part_of GO:0048738 ! cardiac muscle tissue development relationship: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell [Term] id: GO:0055008 name: cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] synonym: "heart muscle morphogenesis" EXACT [] synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0048738 ! cardiac muscle tissue development relationship: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue [Term] id: GO:0055009 name: atrial cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] synonym: "atrial heart muscle morphogenesis" EXACT [] synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac atrium muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development relationship: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium [Term] id: GO:0055010 name: ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] synonym: "cardiac ventricle muscle morphogenesis" EXACT [] synonym: "ventricular heart muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development relationship: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle [Term] id: GO:0055013 name: cardiac muscle cell development namespace: biological_process alt_id: GO:0048739 def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiac muscle fiber development" EXACT [] synonym: "cardiac muscle fibre development" EXACT [] synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] synonym: "heart muscle cell development" EXACT [] synonym: "heart muscle fiber development" RELATED [] is_a: GO:0055002 ! striated muscle cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell relationship: part_of GO:0055007 ! cardiac muscle cell differentiation relationship: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell [Term] id: GO:0055017 name: cardiac muscle tissue growth namespace: biological_process def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] synonym: "heart muscle growth" EXACT [] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0060419 ! heart growth relationship: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue [Term] id: GO:0055018 name: regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "regulation of cardiac muscle fibre development" EXACT [] synonym: "regulation of heart muscle fiber development" EXACT [] is_a: GO:0060284 ! regulation of cell development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development relationship: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development [Term] id: GO:0055019 name: negative regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "down regulation of cardiac muscle fiber development" EXACT [] synonym: "down-regulation of cardiac muscle fiber development" EXACT [] synonym: "downregulation of cardiac muscle fiber development" EXACT [] synonym: "inhibition of cardiac muscle fiber development" NARROW [] synonym: "negative regulation of cardiac muscle fibre development" EXACT [] synonym: "negative regulation of heart muscle fiber development" RELATED [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055018 ! regulation of cardiac muscle fiber development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development relationship: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development [Term] id: GO:0055020 name: positive regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "activation of cardiac muscle fiber development" NARROW [] synonym: "positive regulation of cardiac muscle fibre development" EXACT [] synonym: "positive regulation of heart muscle fiber development" EXACT [] synonym: "stimulation of cardiac muscle fiber development" NARROW [] synonym: "up regulation of cardiac muscle fiber development" EXACT [] synonym: "up-regulation of cardiac muscle fiber development" EXACT [] synonym: "upregulation of cardiac muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0055018 ! regulation of cardiac muscle fiber development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development relationship: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development [Term] id: GO:0055021 name: regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth relationship: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth [Term] id: GO:0055022 name: negative regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "down regulation of cardiac muscle growth" EXACT [] synonym: "down-regulation of cardiac muscle growth" EXACT [] synonym: "downregulation of cardiac muscle growth" EXACT [] synonym: "inhibition of cardiac muscle growth" NARROW [] synonym: "negative regulation of heart muscle growth" RELATED [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0061117 ! negative regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth relationship: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth [Term] id: GO:0055023 name: positive regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "activation of cardiac muscle growth" NARROW [] synonym: "positive regulation of heart muscle growth" EXACT [] synonym: "stimulation of cardiac muscle growth" NARROW [] synonym: "up regulation of cardiac muscle growth" EXACT [] synonym: "up-regulation of cardiac muscle growth" EXACT [] synonym: "upregulation of cardiac muscle growth" EXACT [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060421 ! positive regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth relationship: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth [Term] id: GO:0055024 name: regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "regulation of heart muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development relationship: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development [Term] id: GO:0055025 name: positive regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "activation of cardiac muscle development" NARROW [] synonym: "positive regulation of heart muscle development" EXACT [] synonym: "stimulation of cardiac muscle development" NARROW [] synonym: "up regulation of cardiac muscle development" EXACT [] synonym: "up-regulation of cardiac muscle development" EXACT [] synonym: "upregulation of cardiac muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development relationship: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development [Term] id: GO:0055026 name: negative regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "down regulation of cardiac muscle development" EXACT [] synonym: "down-regulation of cardiac muscle development" EXACT [] synonym: "downregulation of cardiac muscle development" EXACT [] synonym: "inhibition of cardiac muscle development" NARROW [] synonym: "negative regulation of heart muscle development" EXACT [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development relationship: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development [Term] id: GO:0055056 name: D-glucose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015579 def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:jid, GOC:jsg, GOC:mah] xref: Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region" xref: Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" is_a: GO:0015149 ! hexose transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27326 xsd:anyURI [Term] id: GO:0055057 name: neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] synonym: "neuroblast cell division" EXACT [] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007405 ! neuroblast proliferation relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055059 name: asymmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0045165 ! cell fate commitment is_a: GO:0055057 ! neuroblast division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055063 name: sulfate ion homeostasis namespace: biological_process alt_id: GO:0080174 def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah] synonym: "sulfate homeostasis" EXACT [] synonym: "sulphate ion homeostasis" EXACT [] is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:16189 ! regulates levels of sulfate relationship: RO:0002332 CHEBI:16189 ! regulates levels of sulfate [Term] id: GO:0055078 name: sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055080 ! monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:29101 ! regulates levels of sodium(1+) relationship: RO:0002332 CHEBI:29101 ! regulates levels of sodium(1+) [Term] id: GO:0055080 name: monoatomic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah] synonym: "cation homeostasis" BROAD [] is_a: GO:0050801 ! monoatomic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:23906 ! regulates levels of monoatomic cation relationship: RO:0002332 CHEBI:23906 ! regulates levels of monoatomic cation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24455 xsd:anyURI [Term] id: GO:0055082 name: intracellular chemical homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid] synonym: "cellular chemical homeostasis" EXACT [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of chemical entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24514 xsd:anyURI [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process alt_id: GO:0090662 def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] xref: Reactome:R-HSA-382556 "ABC-family proteins mediated transport" xref: Reactome:R-HSA-425407 "SLC-mediated transmembrane transport" xref: Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: RO:0002342 GO:0016020 ! results in transport across membrane created_by: tb creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:R-HSA-15869 "Metabolism of nucleotides" xref: Reactome:R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055088 name: lipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:18059 ! regulates levels of lipid relationship: RO:0002332 CHEBI:18059 ! regulates levels of lipid [Term] id: GO:0055107 name: Golgi to secretory granule transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0055108 name: Golgi to transport vesicle transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030133 ! has target end location transport vesicle relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm relationship: part_of GO:0048193 ! Golgi vesicle transport relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030133 ! has target end location transport vesicle [Term] id: GO:0055117 name: regulation of cardiac muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction relationship: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction [Term] id: GO:0055118 name: negative regulation of cardiac muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0045822 ! negative regulation of heart contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction relationship: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction [Term] id: GO:0055123 name: digestive system development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001007 ! results in development of digestive system relationship: RO:0002296 UBERON:0001007 ! results in development of digestive system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060021 name: roof of mouth development namespace: biological_process def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544] synonym: "palatum development" EXACT [ISBN:0721662544] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007375 ! results in development of roof of mouth relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0007375 ! results in development of roof of mouth [Term] id: GO:0060037 name: pharyngeal system development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0043009 ! chordate embryonic development relationship: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system [Term] id: GO:0060038 name: cardiac muscle cell proliferation namespace: biological_process def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] synonym: "cardiac myocyte proliferation" EXACT [] synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] synonym: "heart muscle cell proliferation" EXACT [] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0055017 ! cardiac muscle tissue growth relationship: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell [Term] id: GO:0060039 name: pericardium development namespace: biological_process def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002407 ! results in development of pericardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0002407 ! results in development of pericardium [Term] id: GO:0060041 name: retina development in camera-type eye namespace: biological_process alt_id: GO:0002073 def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] synonym: "retina development in camera-style eye" EXACT [] synonym: "retinal development" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: part_of GO:0043010 ! camera-type eye development intersection_of: RO:0002296 UBERON:0000966 ! results in development of retina relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0043010 ! camera-type eye development relationship: RO:0002296 UBERON:0000966 ! results in development of retina [Term] id: GO:0060042 name: retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] synonym: "retina morphogenesis in camera-style eye" EXACT [] synonym: "retinogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: part_of GO:0060041 ! retina development in camera-type eye relationship: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina [Term] id: GO:0060043 name: regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] synonym: "regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation relationship: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060044 name: negative regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "negative regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation relationship: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060045 name: positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "positive regulation of heart muscle cell proliferation" RELATED [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation relationship: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: part_of GO:0008015 ! blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060048 name: cardiac muscle contraction namespace: biological_process def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] synonym: "heart muscle contraction" EXACT [] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: part_of GO:0060047 ! heart contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060096 name: serotonin secretion, neurotransmission namespace: biological_process def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph] synonym: "serotonin release, neurotransmission" RELATED [GOC:tb] is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) [Term] id: GO:0060142 name: regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion relationship: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060143 name: positive regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion relationship: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060170 name: ciliary membrane namespace: cellular_component alt_id: GO:0020017 def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial membrane" EXACT [] synonym: "cilium membrane" EXACT [] synonym: "flagellar membrane" NARROW [] synonym: "flagellum membrane" NARROW [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005929 ! cilium relationship: bounding_layer_of GO:0005929 ! cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005929 ! cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060173 name: limb development namespace: biological_process def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] synonym: "limb bud development" NARROW [GOC:dph] synonym: "paired limb/fin development" EXACT [] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin [Term] id: GO:0060214 name: endocardium formation namespace: biological_process def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002165 ! results in formation of anatomical entity endocardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003160 ! endocardium morphogenesis relationship: RO:0002297 UBERON:0002165 ! results in formation of anatomical entity endocardium [Term] id: GO:0060218 name: hematopoietic stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] synonym: "haematopoietic stem cell differentiation" EXACT [] synonym: "haemopoietic stem cell differentiation" EXACT [] synonym: "hemopoietic stem cell differentiation" EXACT [] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell relationship: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell [Term] id: GO:0060219 name: camera-type eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye relationship: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell [Term] id: GO:0060221 name: retinal rod cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell relationship: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell [Term] id: GO:0060231 name: mesenchymal to epithelial transition namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell intersection_of: RO:0004009 CL:0008019 ! has primary input mesenchymal cell relationship: RO:0004009 CL:0008019 ! has primary input mesenchymal cell [Term] id: GO:0060251 name: regulation of glial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014009 ! regulates glial cell proliferation relationship: RO:0002211 GO:0014009 ! regulates glial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060252 name: positive regulation of glial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation relationship: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation [Term] id: GO:0060253 name: negative regulation of glial cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation relationship: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process relationship: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process [Term] id: GO:0060271 name: cilium assembly namespace: biological_process alt_id: GO:0042384 def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833 "Cilium Assembly" is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005929 ! results in assembly of cilium relationship: has_part GO:0035082 ! axoneme assembly relationship: has_part GO:0035735 ! intraciliary transport involved in cilium assembly relationship: has_part GO:0061512 ! protein localization to cilium relationship: has_part GO:0097712 ! vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: has_part GO:1905349 ! ciliary transition zone assembly relationship: RO:0002588 GO:0005929 ! results in assembly of cilium relationship: starts_with GO:0097711 ! ciliary basal body-plasma membrane docking property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048599 ! regulates oocyte development relationship: RO:0002211 GO:0048599 ! regulates oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048599 ! positively regulates oocyte development relationship: RO:0002213 GO:0048599 ! positively regulates oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048599 ! negatively regulates oocyte development relationship: RO:0002212 GO:0048599 ! negatively regulates oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048468 ! regulates cell development relationship: RO:0002211 GO:0048468 ! regulates cell development [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045214 ! regulates sarcomere organization relationship: RO:0002211 GO:0045214 ! regulates sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045214 ! positively regulates sarcomere organization relationship: RO:0002213 GO:0045214 ! positively regulates sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization relationship: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000033 ! results in development of head relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0000033 ! results in development of head [Term] id: GO:0060323 name: head morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000033 ! results in morphogenesis of head relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0010171 ! body morphogenesis relationship: part_of GO:0060322 ! head development relationship: RO:0002298 UBERON:0000033 ! results in morphogenesis of head [Term] id: GO:0060324 name: face development namespace: biological_process def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001456 ! results in development of face relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0060322 ! head development relationship: RO:0002296 UBERON:0001456 ! results in development of face [Term] id: GO:0060325 name: face morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001456 ! results in morphogenesis of face relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0060323 ! head morphogenesis relationship: part_of GO:0060324 ! face development relationship: RO:0002298 UBERON:0001456 ! results in morphogenesis of face [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051641 ! regulates cellular localization relationship: RO:0002211 GO:0051641 ! regulates cellular localization [Term] id: GO:0060343 name: trabecula formation namespace: biological_process def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] synonym: "trabecula biogenesis" RELATED [GOC:dph] synonym: "trabeculation" EXACT [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000440 ! results in formation of anatomical entity trabecula relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0061383 ! trabecula morphogenesis relationship: RO:0002297 UBERON:0000440 ! results in formation of anatomical entity trabecula [Term] id: GO:0060344 name: liver trabecula formation namespace: biological_process def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "liver trabecula biogenesis" RELATED [] synonym: "liver trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0010183 ! results in formation of anatomical entity liver trabecula relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001889 ! liver development relationship: RO:0002297 UBERON:0010183 ! results in formation of anatomical entity liver trabecula [Term] id: GO:0060345 name: spleen trabecula formation namespace: biological_process def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] synonym: "spleen trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001265 ! results in formation of anatomical entity trabecula of spleen relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0048536 ! spleen development relationship: RO:0002297 UBERON:0001265 ! results in formation of anatomical entity trabecula of spleen [Term] id: GO:0060347 name: heart trabecula formation namespace: biological_process def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "cardiac trabecula formation" EXACT [GOC:dph] synonym: "cardiac trabeculation" EXACT [GOC:dph] synonym: "heart trabecula biogenesis" RELATED [GOC:dph] synonym: "heart trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002511 ! results in formation of anatomical entity trabecula carnea relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0061384 ! heart trabecula morphogenesis relationship: RO:0002297 UBERON:0002511 ! results in formation of anatomical entity trabecula carnea [Term] id: GO:0060348 name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048513 ! animal organ development intersection_of: RO:0002296 UBERON:0001474 ! results in development of bone element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001501 ! skeletal system development relationship: RO:0002296 UBERON:0001474 ! results in development of bone element [Term] id: GO:0060349 name: bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0060348 ! bone development relationship: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element [Term] id: GO:0060350 name: endochondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone relationship: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone [Term] id: GO:0060351 name: cartilage development involved in endochondral bone morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0051216 ! cartilage development intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0060359 name: response to ammonium ion namespace: biological_process alt_id: GO:1903717 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] synonym: "response to ammonia" EXACT [] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:28938 ! has primary input ammonium relationship: RO:0004009 CHEBI:28938 ! has primary input ammonium [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation is_a: GO:0045445 ! myoblast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast relationship: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast [Term] id: GO:0060404 name: axonemal microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010938 ! cytoplasmic microtubule depolymerization is_a: GO:0061523 ! cilium disassembly intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005930 ! occurs in axoneme relationship: BFO:0000066 GO:0005930 ! occurs in axoneme [Term] id: GO:0060408 name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process relationship: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process [Term] id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process relationship: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process [Term] id: GO:0060410 name: negative regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008291 ! negatively regulates acetylcholine metabolic process relationship: RO:0002212 GO:0008291 ! negatively regulates acetylcholine metabolic process [Term] id: GO:0060411 name: cardiac septum morphogenesis namespace: biological_process alt_id: GO:0003280 def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] synonym: "heart septum morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003279 ! cardiac septum development relationship: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum [Term] id: GO:0060412 name: ventricular septum morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum relationship: part_of GO:0003281 ! ventricular septum development relationship: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum [Term] id: GO:0060413 name: atrial septum morphogenesis namespace: biological_process alt_id: GO:0003287 def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003283 ! atrial septum development relationship: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum [Term] id: GO:0060414 name: aorta smooth muscle tissue morphogenesis namespace: biological_process def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035909 ! aorta morphogenesis relationship: part_of GO:0048745 ! smooth muscle tissue development relationship: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue [Term] id: GO:0060415 name: muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0048729 ! tissue morphogenesis intersection_of: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048644 ! muscle organ morphogenesis relationship: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000948 ! results in growth of heart relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0007507 ! heart development relationship: RO:0002343 UBERON:0000948 ! results in growth of heart [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060419 ! regulates heart growth relationship: RO:0002211 GO:0060419 ! regulates heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060419 ! positively regulates heart growth relationship: RO:0002213 GO:0060419 ! positively regulates heart growth [Term] id: GO:0060425 name: lung morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung [Term] id: GO:0060426 name: lung vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000102 ! results in development of lung vasculature relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002296 UBERON:0000102 ! results in development of lung vasculature [Term] id: GO:0060427 name: lung connective tissue development namespace: biological_process def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary connective tissue development" EXACT [] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue [Term] id: GO:0060428 name: lung epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000115 ! results in development of lung epithelium relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002296 UBERON:0000115 ! results in development of lung epithelium [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000483 ! results in development of epithelium relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002296 UBERON:0000483 ! results in development of epithelium [Term] id: GO:0060431 name: primary lung bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] synonym: "lung formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis is_a: GO:0060572 ! morphogenesis of an epithelial bud intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002048 ! results in formation of anatomical entity lung relationship: RO:0002297 UBERON:0002048 ! results in formation of anatomical entity lung [Term] id: GO:0060433 name: bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0030323 ! respiratory tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002185 ! results in development of bronchus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060541 ! respiratory system development relationship: RO:0002296 UBERON:0002185 ! results in development of bronchus [Term] id: GO:0060434 name: bronchus morphogenesis namespace: biological_process def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060433 ! bronchus development relationship: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002048 ! results in growth of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002343 UBERON:0002048 ! results in growth of lung [Term] id: GO:0060438 name: trachea development namespace: biological_process def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001005 ! results in development of respiratory airway relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0060541 ! respiratory system development relationship: RO:0002296 UBERON:0001005 ! results in development of respiratory airway [Term] id: GO:0060439 name: trachea morphogenesis namespace: biological_process def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0060438 ! trachea development relationship: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway [Term] id: GO:0060440 name: trachea formation namespace: biological_process def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001005 ! results in formation of anatomical entity respiratory airway relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0060439 ! trachea morphogenesis relationship: RO:0002297 UBERON:0001005 ! results in formation of anatomical entity respiratory airway [Term] id: GO:0060441 name: epithelial tube branching involved in lung morphogenesis namespace: biological_process def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] synonym: "lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0060425 ! lung morphogenesis relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0060425 ! lung morphogenesis [Term] id: GO:0060450 name: positive regulation of hindgut contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043133 ! positively regulates hindgut contraction relationship: RO:0002213 GO:0043133 ! positively regulates hindgut contraction [Term] id: GO:0060451 name: negative regulation of hindgut contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043133 ! negatively regulates hindgut contraction relationship: RO:0002212 GO:0043133 ! negatively regulates hindgut contraction [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction relationship: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction [Term] id: GO:0060453 name: regulation of gastric acid secretion namespace: biological_process def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001696 ! regulates gastric acid secretion relationship: RO:0002211 GO:0001696 ! regulates gastric acid secretion [Term] id: GO:0060454 name: positive regulation of gastric acid secretion namespace: biological_process def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001696 ! positively regulates gastric acid secretion relationship: RO:0002213 GO:0001696 ! positively regulates gastric acid secretion [Term] id: GO:0060455 name: negative regulation of gastric acid secretion namespace: biological_process def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001696 ! negatively regulates gastric acid secretion relationship: RO:0002212 GO:0001696 ! negatively regulates gastric acid secretion [Term] id: GO:0060456 name: positive regulation of digestive system process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022600 ! positively regulates digestive system process relationship: RO:0002213 GO:0022600 ! positively regulates digestive system process [Term] id: GO:0060457 name: negative regulation of digestive system process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022600 ! negatively regulates digestive system process relationship: RO:0002212 GO:0022600 ! negatively regulates digestive system process [Term] id: GO:0060458 name: right lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002167 ! results in development of right lung relationship: RO:0002296 UBERON:0002167 ! results in development of right lung [Term] id: GO:0060459 name: left lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "left pulmonary development" EXACT [GOC:dph] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002168 ! results in development of left lung relationship: RO:0002296 UBERON:0002168 ! results in development of left lung [Term] id: GO:0060460 name: left lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung relationship: part_of GO:0060459 ! left lung development relationship: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung [Term] id: GO:0060461 name: right lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung relationship: part_of GO:0060458 ! right lung development relationship: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung [Term] id: GO:0060462 name: lung lobe development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000101 ! results in development of lobe of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development relationship: RO:0002296 UBERON:0000101 ! results in development of lobe of lung [Term] id: GO:0060463 name: lung lobe morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000101 ! results in morphogenesis of lobe of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060462 ! lung lobe development relationship: RO:0002298 UBERON:0000101 ! results in morphogenesis of lobe of lung [Term] id: GO:0060464 name: lung lobe formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000101 ! results in formation of anatomical entity lobe of lung relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0060463 ! lung lobe morphogenesis relationship: RO:0002297 UBERON:0000101 ! results in formation of anatomical entity lobe of lung [Term] id: GO:0060465 name: pharynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] synonym: "pharyngeal development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006562 ! results in development of pharynx relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002296 UBERON:0006562 ! results in development of pharynx [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009566 ! negatively regulates fertilization relationship: RO:0002212 GO:0009566 ! negatively regulates fertilization [Term] id: GO:0060479 name: lung cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060485 name: mesenchyme development namespace: biological_process def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] synonym: "mesenchymal development" EXACT [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003104 ! results in development of mesenchyme relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0048513 ! animal organ development relationship: RO:0002296 UBERON:0003104 ! results in development of mesenchyme [Term] id: GO:0060487 name: lung epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060479 ! lung cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung relationship: part_of GO:0060428 ! lung epithelium development relationship: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030031 ! regulates cell projection assembly relationship: RO:0002211 GO:0030031 ! regulates cell projection assembly [Term] id: GO:0060495 name: cell-cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0030324 ! lung development relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060496 name: mesenchymal-epithelial cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: part_of GO:0030324 ! lung development [Term] id: GO:0060497 name: mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell [Term] id: GO:0060501 name: positive regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060502 name: epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0060425 ! lung morphogenesis relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060532 name: bronchus cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cartilage development" EXACT [] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060433 ! bronchus development relationship: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus created_by: dph creation_date: 2009-04-10T08:12:06Z [Term] id: GO:0060533 name: bronchus cartilage morphogenesis namespace: biological_process def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060434 ! bronchus morphogenesis relationship: part_of GO:0060532 ! bronchus cartilage development relationship: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus created_by: dph creation_date: 2009-04-10T08:47:41Z [Term] id: GO:0060534 name: trachea cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060438 ! trachea development relationship: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage created_by: dph creation_date: 2009-04-10T09:00:18Z [Term] id: GO:0060535 name: trachea cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060439 ! trachea morphogenesis relationship: part_of GO:0060534 ! trachea cartilage development relationship: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage created_by: dph creation_date: 2009-04-10T09:07:48Z [Term] id: GO:0060536 name: cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0051216 ! cartilage development relationship: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element created_by: dph creation_date: 2009-04-10T09:13:27Z [Term] id: GO:0060537 name: muscle tissue development namespace: biological_process def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002385 ! results in development of muscle tissue relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0002385 ! results in development of muscle tissue created_by: dph creation_date: 2009-04-10T08:05:37Z [Term] id: GO:0060538 name: skeletal muscle organ development namespace: biological_process def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] is_a: GO:0007517 ! muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate created_by: dph creation_date: 2009-04-10T08:25:12Z [Term] id: GO:0060539 name: diaphragm development namespace: biological_process def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] is_a: GO:0060538 ! skeletal muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001103 ! results in development of diaphragm relationship: in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of GO:0060541 ! respiratory system development relationship: RO:0002296 UBERON:0001103 ! results in development of diaphragm created_by: dph creation_date: 2009-04-10T08:44:56Z [Term] id: GO:0060540 name: diaphragm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] is_a: GO:0048644 ! muscle organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm relationship: in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of GO:0060539 ! diaphragm development relationship: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm created_by: dph creation_date: 2009-04-10T08:47:51Z [Term] id: GO:0060541 name: respiratory system development namespace: biological_process def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] subset: goslim_drosophila is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001004 ! results in development of respiratory system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0001004 ! results in development of respiratory system created_by: dph creation_date: 2009-04-10T08:55:42Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: dph creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube relationship: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube created_by: dph creation_date: 2009-04-28T09:33:36Z [Term] id: GO:0060563 name: neuroepithelial cell differentiation namespace: biological_process def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell created_by: dph creation_date: 2009-04-29T01:50:05Z [Term] id: GO:0060571 name: morphogenesis of an epithelial fold namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] synonym: "epithelial folding" EXACT [GOC:dph] synonym: "folding of an epithelial sheet" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold relationship: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold created_by: dph creation_date: 2009-04-30T09:27:17Z [Term] id: GO:0060572 name: morphogenesis of an epithelial bud namespace: biological_process def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud relationship: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud created_by: dph creation_date: 2009-04-30T09:38:35Z [Term] id: GO:0060574 name: intestinal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0002563 ! results in maturation of intestinal epithelial cell relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0060576 ! intestinal epithelial cell development relationship: RO:0002299 CL:0002563 ! results in maturation of intestinal epithelial cell created_by: dph creation_date: 2009-05-06T08:10:41Z [Term] id: GO:0060575 name: intestinal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002563 ! results in acquisition of features of intestinal epithelial cell relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002315 CL:0002563 ! results in acquisition of features of intestinal epithelial cell created_by: dph creation_date: 2009-05-06T08:17:56Z [Term] id: GO:0060576 name: intestinal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002563 ! results in development of intestinal epithelial cell relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation relationship: RO:0002296 CL:0002563 ! results in development of intestinal epithelial cell created_by: dph creation_date: 2009-05-06T08:20:24Z [Term] id: GO:0060577 name: pulmonary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein relationship: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein created_by: dph creation_date: 2009-05-06T08:44:04Z [Term] id: GO:0060578 name: superior vena cava morphogenesis namespace: biological_process def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava relationship: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava created_by: dph creation_date: 2009-05-06T08:47:21Z [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: part_of GO:0007389 ! pattern specification process relationship: part_of GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2009-05-07T12:40:55Z [Term] id: GO:0060591 name: chondroblast differentiation namespace: biological_process def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0051216 ! cartilage development relationship: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast created_by: dph creation_date: 2009-05-11T07:47:36Z [Term] id: GO:0060612 name: adipose tissue development namespace: biological_process def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001013 ! results in development of adipose tissue relationship: part_of GO:0048513 ! animal organ development relationship: RO:0002296 UBERON:0001013 ! results in development of adipose tissue created_by: dph creation_date: 2009-05-15T12:36:28Z [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030261 ! regulates chromosome condensation relationship: RO:0002211 GO:0030261 ! regulates chromosome condensation created_by: dph creation_date: 2009-05-18T02:12:13Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport relationship: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007018 ! regulates microtubule-based movement relationship: RO:0002211 GO:0007018 ! regulates microtubule-based movement created_by: dph creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060638 name: mesenchymal-epithelial cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000066 ! has end location epithelial cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000066 ! has end location epithelial cell created_by: dph creation_date: 2009-05-19T03:59:05Z [Term] id: GO:0060684 name: epithelial-mesenchymal cell signaling namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000066 ! has start location epithelial cell intersection_of: RO:0002232 CL:0008019 ! has end location mesenchymal cell relationship: RO:0002231 CL:0000066 ! has start location epithelial cell relationship: RO:0002232 CL:0008019 ! has end location mesenchymal cell created_by: dph creation_date: 2009-06-03T06:36:46Z [Term] id: GO:0060688 name: regulation of morphogenesis of a branching structure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure relationship: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure created_by: dph creation_date: 2009-06-05T12:41:44Z [Term] id: GO:0060788 name: ectodermal placode formation namespace: biological_process def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005085 ! results in formation of anatomical entity ectodermal placode relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0071697 ! ectodermal placode morphogenesis relationship: RO:0002297 UBERON:0005085 ! results in formation of anatomical entity ectodermal placode created_by: dph creation_date: 2009-08-04T12:15:57Z [Term] id: GO:0060795 name: cell fate commitment involved in formation of primary germ layer namespace: biological_process def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: part_of GO:0001704 ! formation of primary germ layer relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0001704 ! formation of primary germ layer created_by: dph creation_date: 2009-08-04T03:11:22Z [Term] id: GO:0060837 name: blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell relationship: part_of GO:0001568 ! blood vessel development relationship: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell created_by: dph creation_date: 2009-08-11T03:47:36Z [Term] id: GO:0060840 name: artery development namespace: biological_process def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001637 ! results in development of artery relationship: RO:0002296 UBERON:0001637 ! results in development of artery created_by: dph creation_date: 2009-08-12T10:10:51Z [Term] id: GO:0060841 name: venous blood vessel development namespace: biological_process def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001638 ! results in development of vein relationship: RO:0002296 UBERON:0001638 ! results in development of vein created_by: dph creation_date: 2009-08-12T10:14:07Z [Term] id: GO:0060842 name: arterial endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery relationship: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery created_by: dph creation_date: 2009-08-12T10:41:34Z [Term] id: GO:0060843 name: venous endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell relationship: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell created_by: dph creation_date: 2009-08-12T10:43:40Z [Term] id: GO:0060896 name: neural plate pattern specification namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9834899 "Specification of the neural plate border" is_a: GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2009-08-13T02:06:27Z [Term] id: GO:0060897 name: neural plate regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060896 ! neural plate pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2009-08-13T02:09:04Z [Term] id: GO:0060900 name: embryonic camera-type eye formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis created_by: dph creation_date: 2009-08-13T02:26:54Z [Term] id: GO:0060914 name: heart formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "cardiogenesis" RELATED [GOC:mtg_heart] xref: Reactome:R-HSA-9733709 "Cardiogenesis" is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000948 ! results in formation of anatomical entity heart relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003007 ! heart morphogenesis relationship: RO:0002297 UBERON:0000948 ! results in formation of anatomical entity heart created_by: dph creation_date: 2009-09-17T09:02:13Z [Term] id: GO:0060915 name: mesenchymal cell differentiation involved in lung development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0030324 ! lung development relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development created_by: dph creation_date: 2009-09-18T11:45:33Z [Term] id: GO:0060916 name: mesenchymal cell proliferation involved in lung development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: part_of GO:0030324 ! lung development relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0030324 ! lung development created_by: dph creation_date: 2009-09-18T11:50:17Z [Term] id: GO:0060920 name: cardiac pacemaker cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell differentiation" BROAD [] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte relationship: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte created_by: dph creation_date: 2009-09-29T11:01:31Z [Term] id: GO:0060921 name: sinoatrial node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003163 ! sinoatrial node development relationship: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node created_by: dph creation_date: 2009-09-29T11:03:30Z [Term] id: GO:0060922 name: atrioventricular node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] is_a: GO:0003292 ! cardiac septum cell differentiation is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node relationship: part_of GO:0003162 ! atrioventricular node development relationship: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node created_by: dph creation_date: 2009-09-29T11:07:06Z [Term] id: GO:0060926 name: cardiac pacemaker cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell development" BROAD [] is_a: GO:0055013 ! cardiac muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002072 ! results in development of nodal myocyte relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation relationship: RO:0002296 CL:0002072 ! results in development of nodal myocyte created_by: dph creation_date: 2009-09-29T11:51:55Z [Term] id: GO:0060928 name: atrioventricular node cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "AV node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060922 ! atrioventricular node cell differentiation relationship: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node created_by: dph creation_date: 2009-09-29T11:59:26Z [Term] id: GO:0060931 name: sinoatrial node cell development namespace: biological_process def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell development" EXACT [GOC:mtg_heart] synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060921 ! sinoatrial node cell differentiation relationship: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node created_by: dph creation_date: 2009-09-29T12:05:47Z [Term] id: GO:0060932 name: His-Purkinje system cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell relationship: in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of GO:0003164 ! His-Purkinje system development relationship: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell created_by: dph creation_date: 2009-09-29T01:10:32Z [Term] id: GO:0060933 name: His-Purkinje system cell development namespace: biological_process def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell relationship: in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation relationship: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell created_by: dph creation_date: 2009-09-29T01:15:02Z [Term] id: GO:0060935 name: cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue created_by: dph creation_date: 2009-09-29T01:20:04Z [Term] id: GO:0060936 name: cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation relationship: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue created_by: dph creation_date: 2009-09-29T01:23:03Z [Term] id: GO:0060945 name: cardiac neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048934 ! peripheral nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048483 ! autonomic nervous system development relationship: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron created_by: dph creation_date: 2009-09-29T02:45:33Z [Term] id: GO:0060946 name: cardiac blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell relationship: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell created_by: dph creation_date: 2009-09-29T02:48:55Z [Term] id: GO:0060950 name: cardiac glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell created_by: dph creation_date: 2009-09-29T03:06:37Z [Term] id: GO:0060952 name: cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] is_a: GO:0021782 ! glial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010020 ! results in development of cardiac glial cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060950 ! cardiac glial cell differentiation relationship: RO:0002296 CL:0010020 ! results in development of cardiac glial cell created_by: dph creation_date: 2009-09-29T03:09:24Z [Term] id: GO:0060956 name: endocardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell relationship: part_of GO:0003157 ! endocardium development relationship: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell created_by: dph creation_date: 2009-09-29T03:20:39Z [Term] id: GO:0060958 name: endocardial cell development namespace: biological_process def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0001885 ! endothelial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002350 ! results in development of endocardial cell relationship: part_of GO:0060956 ! endocardial cell differentiation relationship: RO:0002296 CL:0002350 ! results in development of endocardial cell created_by: dph creation_date: 2009-09-29T03:26:59Z [Term] id: GO:0060959 name: cardiac neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart neuron development" EXACT [GOC:mtg_heart] is_a: GO:0048935 ! peripheral nervous system neuron development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010022 ! results in development of cardiac neuron relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060945 ! cardiac neuron differentiation relationship: RO:0002296 CL:0010022 ! results in development of cardiac neuron created_by: dph creation_date: 2009-09-30T10:14:56Z [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007507 ! heart development relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-06T10:53:49Z [Term] id: GO:0060974 name: cell migration involved in heart formation namespace: biological_process def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060914 ! heart formation relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060914 ! heart formation created_by: dph creation_date: 2009-10-06T10:56:33Z [Term] id: GO:0060976 name: coronary vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart vasculature development" EXACT [GOC:mtg_heart] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel relationship: part_of GO:0007507 ! heart development relationship: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel created_by: dph creation_date: 2009-10-06T12:15:23Z [Term] id: GO:0060977 name: coronary vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel relationship: part_of GO:0060976 ! coronary vasculature development relationship: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel created_by: dph creation_date: 2009-10-06T12:28:23Z [Term] id: GO:0060978 name: angiogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: part_of GO:0060976 ! coronary vasculature development relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-06T02:02:12Z [Term] id: GO:0060979 name: vasculogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-06T02:19:42Z [Term] id: GO:0060980 name: cell migration involved in coronary vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] is_a: GO:0035441 ! cell migration involved in vasculogenesis is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis created_by: dph creation_date: 2009-10-06T02:33:06Z [Term] id: GO:0060981 name: cell migration involved in coronary angiogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis created_by: dph creation_date: 2009-10-06T02:49:12Z [Term] id: GO:0060986 name: endocrine hormone secretion namespace: biological_process def: "The regulated release of a hormone into the circulatory system." [GOC:dph] is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0050886 ! endocrine process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2010-01-11T09:03:48Z [Term] id: GO:0061007 name: hepaticobiliary system process namespace: biological_process def: "A system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] subset: goslim_generic synonym: "hepatobiliary system process" EXACT [GOC:dph] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2010-01-22T09:09:10Z [Term] id: GO:0061008 name: hepaticobiliary system development namespace: biological_process def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system development" EXACT [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002423 ! results in development of hepatobiliary system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0002423 ! results in development of hepatobiliary system created_by: dph creation_date: 2010-01-22T09:11:59Z [Term] id: GO:0061009 name: common bile duct development namespace: biological_process def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine." [PMID:20614624] synonym: "bile duct development" EXACT [GOC:dph] synonym: "CBD development" EXACT [PMID:20614624] synonym: "EHBD development" BROAD [PMID:20614624] synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002394 ! results in development of bile duct relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061008 ! hepaticobiliary system development relationship: RO:0002296 UBERON:0002394 ! results in development of bile duct created_by: dph creation_date: 2010-01-22T09:17:13Z [Term] id: GO:0061010 name: gallbladder development namespace: biological_process def: "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002110 ! results in development of gallbladder relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061008 ! hepaticobiliary system development relationship: RO:0002296 UBERON:0002110 ! results in development of gallbladder created_by: dph creation_date: 2010-01-22T09:38:44Z [Term] id: GO:0061011 name: hepatic duct development namespace: biological_process def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001175 ! results in development of common hepatic duct relationship: RO:0002296 UBERON:0001175 ! results in development of common hepatic duct created_by: dph creation_date: 2010-01-22T09:44:39Z [Term] id: GO:0061017 name: hepatoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000488 ! results in acquisition of features of cholangiocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001889 ! liver development relationship: RO:0002315 CL:1000488 ! results in acquisition of features of cholangiocyte created_by: dph creation_date: 2010-02-02T09:08:03Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] xref: Reactome:R-HSA-199991 "Membrane Trafficking" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0016020 ! results in organization of membrane relationship: RO:0002592 GO:0016020 ! results in organization of membrane created_by: jl creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process alt_id: GO:0006944 alt_id: GO:0044801 def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] synonym: "single-organism membrane fusion" RELATED [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: RO:0012008 GO:0016020 ! results in fusion of membrane relationship: RO:0012008 GO:0016020 ! results in fusion of membrane created_by: jl creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061032 name: visceral serous pericardium development namespace: biological_process def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf] synonym: "epicardium development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060039 ! pericardium development relationship: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium created_by: dph creation_date: 2010-02-09T09:52:49Z [Term] id: GO:0061035 name: regulation of cartilage development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051216 ! regulates cartilage development relationship: RO:0002211 GO:0051216 ! regulates cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061036 name: positive regulation of cartilage development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051216 ! positively regulates cartilage development relationship: RO:0002213 GO:0051216 ! positively regulates cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061037 name: negative regulation of cartilage development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051216 ! negatively regulates cartilage development relationship: RO:0002212 GO:0051216 ! negatively regulates cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061040 name: female gonad morphogenesis namespace: biological_process def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035262 ! gonad morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary relationship: part_of GO:0008585 ! female gonad development relationship: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary created_by: dph creation_date: 2010-02-22T11:29:28Z [Term] id: GO:0061046 name: regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:41:38Z [Term] id: GO:0061047 name: positive regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:50:01Z [Term] id: GO:0061048 name: negative regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:51:31Z [Term] id: GO:0061049 name: cell growth involved in cardiac muscle cell development namespace: biological_process def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] synonym: "cardiomyocyte growth" RELATED [GOC:dph] synonym: "heart muscle cell growth" RELATED [GOC:dph] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0016049 ! cell growth intersection_of: part_of GO:0055013 ! cardiac muscle cell development relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy relationship: part_of GO:0055013 ! cardiac muscle cell development created_by: dph creation_date: 2010-02-25T12:56:07Z [Term] id: GO:0061050 name: regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development relationship: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:05:16Z [Term] id: GO:0061051 name: positive regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:08:08Z [Term] id: GO:0061052 name: negative regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:11:30Z [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002329 ! results in development of somite relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0009790 ! embryo development relationship: RO:0002296 UBERON:0002329 ! results in development of somite created_by: dph creation_date: 2010-03-02T12:05:13Z [Term] id: GO:0061054 name: dermatome development namespace: biological_process def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004016 ! results in development of dermatome relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0061053 ! somite development relationship: RO:0002296 UBERON:0004016 ! results in development of dermatome created_by: dph creation_date: 2010-03-02T12:07:37Z [Term] id: GO:0061055 name: myotome development namespace: biological_process def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003082 ! results in development of myotome relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0061053 ! somite development relationship: RO:0002296 UBERON:0003082 ! results in development of myotome created_by: dph creation_date: 2010-03-02T12:11:01Z [Term] id: GO:0061056 name: sclerotome development namespace: biological_process def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003089 ! results in development of sclerotome relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061053 ! somite development relationship: RO:0002296 UBERON:0003089 ! results in development of sclerotome created_by: dph creation_date: 2010-03-02T12:12:40Z [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] subset: goslim_drosophila is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005090 ! results in development of muscle structure relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0005090 ! results in development of muscle structure created_by: dph creation_date: 2010-03-09T08:55:14Z [Term] id: GO:0061062 name: regulation of nematode larval development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002119 ! regulates nematode larval development relationship: RO:0002211 GO:0002119 ! regulates nematode larval development created_by: dph creation_date: 2010-03-11T12:59:21Z [Term] id: GO:0061063 name: positive regulation of nematode larval development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002119 ! positively regulates nematode larval development relationship: RO:0002213 GO:0002119 ! positively regulates nematode larval development created_by: dph creation_date: 2010-03-11T01:03:34Z [Term] id: GO:0061064 name: negative regulation of nematode larval development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002119 ! negatively regulates nematode larval development relationship: RO:0002212 GO:0002119 ! negatively regulates nematode larval development created_by: dph creation_date: 2010-03-11T01:04:39Z [Term] id: GO:0061072 name: iris morphogenesis namespace: biological_process def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris created_by: dph creation_date: 2010-03-16T10:48:42Z [Term] id: GO:0061073 name: ciliary body morphogenesis namespace: biological_process def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body created_by: dph creation_date: 2010-03-16T10:55:19Z [Term] id: GO:0061074 name: regulation of neural retina development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003407 ! regulates neural retina development relationship: RO:0002211 GO:0003407 ! regulates neural retina development created_by: dph creation_date: 2010-03-16T11:47:05Z [Term] id: GO:0061075 name: positive regulation of neural retina development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902868 ! positive regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003407 ! positively regulates neural retina development relationship: RO:0002213 GO:0003407 ! positively regulates neural retina development created_by: dph creation_date: 2010-03-16T11:59:48Z [Term] id: GO:0061076 name: negative regulation of neural retina development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902867 ! negative regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003407 ! negatively regulates neural retina development relationship: RO:0002212 GO:0003407 ! negatively regulates neural retina development created_by: dph creation_date: 2010-03-16T12:46:11Z [Term] id: GO:0061080 name: right horn of sinus venosus development namespace: biological_process def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003235 ! sinus venosus development relationship: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus created_by: dph creation_date: 2010-04-08T02:45:10Z [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] is_a: GO:0061101 ! neuroendocrine cell differentiation is_a: GO:0061140 ! lung secretory cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell relationship: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell created_by: dph creation_date: 2010-04-27T03:28:46Z [Term] id: GO:0061101 name: neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060563 ! neuroepithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell relationship: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell created_by: dph creation_date: 2010-04-28T09:42:20Z [Term] id: GO:0061102 name: stomach neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746] synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000222 ! results in acquisition of features of stomach neuroendocrine cell relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0062094 ! stomach development relationship: RO:0002315 CL:1000222 ! results in acquisition of features of stomach neuroendocrine cell created_by: dph creation_date: 2010-04-28T09:47:07Z [Term] id: GO:0061105 name: regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061102 ! regulates stomach neuroendocrine cell differentiation relationship: RO:0002211 GO:0061102 ! regulates stomach neuroendocrine cell differentiation created_by: dph creation_date: 2010-04-29T12:19:37Z [Term] id: GO:0061106 name: negative regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061102 ! negatively regulates stomach neuroendocrine cell differentiation relationship: RO:0002212 GO:0061102 ! negatively regulates stomach neuroendocrine cell differentiation created_by: dph creation_date: 2010-04-29T12:23:05Z [Term] id: GO:0061109 name: dense core granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] synonym: "dense core granule organisation" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031045 ! results in organization of dense core granule relationship: RO:0002592 GO:0031045 ! results in organization of dense core granule created_by: dph creation_date: 2010-05-01T09:34:37Z [Term] id: GO:0061111 name: epithelial-mesenchymal cell signaling involved in lung development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: part_of GO:0030324 ! lung development created_by: dph creation_date: 2010-05-05T11:14:38Z [Term] id: GO:0061113 name: pancreas morphogenesis namespace: biological_process def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001264 ! results in morphogenesis of pancreas relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0031016 ! pancreas development relationship: RO:0002298 UBERON:0001264 ! results in morphogenesis of pancreas created_by: dph creation_date: 2010-05-05T11:55:30Z [Term] id: GO:0061114 name: branching involved in pancreas morphogenesis namespace: biological_process def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0061113 ! pancreas morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061113 ! pancreas morphogenesis created_by: dph creation_date: 2010-05-05T12:03:04Z [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060419 ! negatively regulates heart growth relationship: RO:0002212 GO:0060419 ! negatively regulates heart growth created_by: dph creation_date: 2010-05-17T07:31:28Z [Term] id: GO:0061130 name: pancreatic bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] is_a: GO:0048645 ! animal organ formation is_a: GO:0061114 ! branching involved in pancreas morphogenesis is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003922 ! results in formation of anatomical entity pancreatic epithelial bud relationship: RO:0002297 UBERON:0003922 ! results in formation of anatomical entity pancreatic epithelial bud created_by: dph creation_date: 2010-05-17T09:33:40Z [Term] id: GO:0061138 name: morphogenesis of a branching epithelium namespace: biological_process def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0002009 ! morphogenesis of an epithelium created_by: dph creation_date: 2010-05-25T09:05:34Z [Term] id: GO:0061140 name: lung secretory cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell relationship: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell created_by: dph creation_date: 2010-05-25T09:28:53Z [Term] id: GO:0061147 name: endocardial endothelium development namespace: biological_process def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0003158 ! endothelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium relationship: part_of GO:0003157 ! endocardium development relationship: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium created_by: dph creation_date: 2010-06-03T09:15:31Z [Term] id: GO:0061148 name: extracellular matrix organization involved in endocardium development namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0030198 ! extracellular matrix organization intersection_of: part_of GO:0003157 ! endocardium development relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2010-06-03T09:18:02Z [Term] id: GO:0061152 name: trachea submucosa development namespace: biological_process def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060438 ! trachea development relationship: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea created_by: dph creation_date: 2010-06-07T09:58:40Z [Term] id: GO:0061153 name: trachea gland development namespace: biological_process def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005203 ! results in development of trachea gland relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061152 ! trachea submucosa development relationship: RO:0002296 UBERON:0005203 ! results in development of trachea gland created_by: dph creation_date: 2010-06-07T10:10:51Z [Term] id: GO:0061154 name: endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf] is_a: GO:0003159 ! morphogenesis of an endothelium is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube relationship: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube created_by: dph creation_date: 2010-06-15T09:05:00Z [Term] id: GO:0061155 name: pulmonary artery endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf] is_a: GO:0061154 ! endothelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium relationship: part_of GO:0061156 ! pulmonary artery morphogenesis relationship: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium created_by: dph creation_date: 2010-06-15T09:09:04Z [Term] id: GO:0061156 name: pulmonary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery relationship: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery created_by: dph creation_date: 2010-06-15T09:13:47Z [Term] id: GO:0061178 name: regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] is_a: GO:0050796 ! regulation of insulin secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035773 ! regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002211 GO:0035773 ! regulates insulin secretion involved in cellular response to glucose stimulus created_by: dph creation_date: 2010-07-13T09:38:42Z [Term] id: GO:0061179 name: negative regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph] synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0046676 ! negative regulation of insulin secretion is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035773 ! negatively regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002212 GO:0035773 ! negatively regulates insulin secretion involved in cellular response to glucose stimulus created_by: dph creation_date: 2010-07-13T09:41:46Z [Term] id: GO:0061181 name: regulation of chondrocyte development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002063 ! regulates chondrocyte development relationship: RO:0002211 GO:0002063 ! regulates chondrocyte development created_by: dph creation_date: 2010-07-14T08:28:52Z [Term] id: GO:0061182 name: negative regulation of chondrocyte development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0032331 ! negative regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development relationship: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development created_by: dph creation_date: 2010-07-14T08:33:05Z [Term] id: GO:0061183 name: regulation of dermatome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061054 ! regulates dermatome development relationship: RO:0002211 GO:0061054 ! regulates dermatome development created_by: dph creation_date: 2010-07-14T08:40:26Z [Term] id: GO:0061184 name: positive regulation of dermatome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061054 ! positively regulates dermatome development relationship: RO:0002213 GO:0061054 ! positively regulates dermatome development created_by: dph creation_date: 2010-07-14T08:42:03Z [Term] id: GO:0061185 name: negative regulation of dermatome development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061054 ! negatively regulates dermatome development relationship: RO:0002212 GO:0061054 ! negatively regulates dermatome development created_by: dph creation_date: 2010-07-14T08:43:08Z [Term] id: GO:0061189 name: positive regulation of sclerotome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061190 ! regulation of sclerotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061056 ! positively regulates sclerotome development relationship: RO:0002213 GO:0061056 ! positively regulates sclerotome development created_by: dph creation_date: 2010-07-14T09:17:23Z [Term] id: GO:0061190 name: regulation of sclerotome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061056 ! regulates sclerotome development relationship: RO:0002211 GO:0061056 ! regulates sclerotome development created_by: dph creation_date: 2010-07-14T09:19:47Z [Term] id: GO:0061298 name: retina vasculature development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] synonym: "retinal vasculature development" EXACT [GOC:dph] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina relationship: part_of GO:0060041 ! retina development in camera-type eye relationship: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina created_by: dph creation_date: 2010-09-06T03:27:06Z [Term] id: GO:0061299 name: retina vasculature morphogenesis in camera-type eye namespace: biological_process def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye relationship: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina created_by: dph creation_date: 2010-09-06T03:28:25Z [Term] id: GO:0061303 name: cornea development in camera-type eye namespace: biological_process def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000964 ! results in development of cornea relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0043010 ! camera-type eye development relationship: RO:0002296 UBERON:0000964 ! results in development of cornea created_by: dph creation_date: 2010-09-14T02:09:08Z [Term] id: GO:0061304 name: retinal blood vessel morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel relationship: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel created_by: dph creation_date: 2010-09-16T09:02:59Z [Term] id: GO:0061307 name: cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] is_a: GO:0014033 ! neural crest cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T08:50:56Z [Term] id: GO:0061308 name: cardiac neural crest cell development involved in heart development namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0014032 ! neural crest cell development intersection_of: GO:0014032 ! neural crest cell development intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development created_by: dph creation_date: 2010-09-23T09:01:49Z [Term] id: GO:0061309 name: cardiac neural crest cell development involved in outflow tract morphogenesis namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development intersection_of: GO:0014032 ! neural crest cell development intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2010-09-23T09:08:37Z [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-28T09:05:26Z [Term] id: GO:0061325 name: cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2010-09-28T09:29:30Z [Term] id: GO:0061337 name: cardiac conduction namespace: biological_process def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph] xref: Reactome:R-HSA-5576891 "Cardiac conduction" is_a: GO:0008016 ! regulation of heart contraction created_by: dph creation_date: 2010-09-29T08:46:05Z [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] is_a: GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-10-01T11:06:04Z [Term] id: GO:0061383 name: trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000440 ! results in morphogenesis of trabecula relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002298 UBERON:0000440 ! results in morphogenesis of trabecula created_by: dph creation_date: 2010-12-02T08:51:45Z [Term] id: GO:0061384 name: heart trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0061383 ! trabecula morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002511 ! results in morphogenesis of trabecula carnea relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002298 UBERON:0002511 ! results in morphogenesis of trabecula carnea created_by: dph creation_date: 2010-12-02T08:54:20Z [Term] id: GO:0061385 name: fibroblast proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] is_a: GO:0048144 ! fibroblast proliferation is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0048144 ! fibroblast proliferation intersection_of: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2011-02-10T01:41:59Z [Term] id: GO:0061448 name: connective tissue development namespace: biological_process def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002384 ! results in development of connective tissue relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0002384 ! results in development of connective tissue created_by: dph creation_date: 2012-03-22T12:53:41Z [Term] id: GO:0061453 name: interstitial cell of Cajal differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph] synonym: "ICC differentiation" RELATED [GOC:dph] is_a: GO:0060563 ! neuroepithelial cell differentiation is_a: GO:0060575 ! intestinal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002088 ! results in acquisition of features of interstitial cell of Cajal relationship: RO:0002315 CL:0002088 ! results in acquisition of features of interstitial cell of Cajal created_by: dph creation_date: 2012-07-20T08:20:50Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000990 ! results in development of reproductive system relationship: RO:0002296 UBERON:0000990 ! results in development of reproductive system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061469 name: regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044342 ! regulates type B pancreatic cell proliferation relationship: RO:0002211 GO:0044342 ! regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2012-11-01T13:16:23Z [Term] id: GO:0061484 name: hematopoietic stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411] is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: dph creation_date: 2012-12-04T09:41:02Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005929 ! has target end location cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: RO:0002339 GO:0005929 ! has target end location cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: dph creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061515 name: myeloid cell development namespace: biological_process def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0030097 ! hemopoiesis intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000763 ! results in development of myeloid cell relationship: part_of GO:0030099 ! myeloid cell differentiation relationship: RO:0002296 CL:0000763 ! results in development of myeloid cell created_by: dph creation_date: 2013-04-18T13:03:16Z [Term] id: GO:0061523 name: cilium disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "cilium resorption" EXACT [GOC:dph] is_a: GO:0044782 ! cilium organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005929 ! results in disassembly of cilium relationship: RO:0002590 GO:0005929 ! results in disassembly of cilium created_by: dph creation_date: 2013-04-18T14:59:59Z [Term] id: GO:0061525 name: hindgut development namespace: biological_process def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph] is_a: GO:0048565 ! digestive tract development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001046 ! results in development of hindgut relationship: RO:0002296 UBERON:0001046 ! results in development of hindgut created_by: dph creation_date: 2013-06-14T11:22:21Z [Term] id: GO:0061526 name: acetylcholine secretion namespace: biological_process def: "The regulated release of acetylcholine by a cell." [GOC:dph] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine created_by: dph creation_date: 2013-06-21T15:40:39Z [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission namespace: biological_process def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph] synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0048243 ! norepinephrine secretion is_a: GO:0160043 ! catecholamine secretion, neurotransmission intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) created_by: dph creation_date: 2013-06-21T16:05:08Z [Term] id: GO:0061548 name: ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "ganglia development" RELATED [GOC:dph] synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000045 ! results in development of ganglion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007399 ! nervous system development relationship: RO:0002296 UBERON:0000045 ! results in development of ganglion created_by: dph creation_date: 2013-07-10T08:36:12Z [Term] id: GO:0061549 name: sympathetic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl] synonym: "sympathetic ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048485 ! sympathetic nervous system development relationship: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion created_by: dph creation_date: 2013-07-10T08:38:01Z [Term] id: GO:0061550 name: cranial ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "cranial ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021545 ! cranial nerve development relationship: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion created_by: dph creation_date: 2013-07-10T08:40:14Z [Term] id: GO:0061551 name: trigeminal ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "trigeminal ganglia development" RELATED [GOC:dph] is_a: GO:0061550 ! cranial ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion relationship: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion created_by: dph creation_date: 2013-07-10T08:42:19Z [Term] id: GO:0061552 name: ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph] synonym: "ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0061548 ! ganglion development relationship: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion created_by: dph creation_date: 2013-07-10T08:44:57Z [Term] id: GO:0061553 name: ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] synonym: "ganglia maturation" RELATED [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0000045 ! results in maturation of ganglion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0061548 ! ganglion development relationship: RO:0002299 UBERON:0000045 ! results in maturation of ganglion created_by: dph creation_date: 2013-07-10T08:45:59Z [Term] id: GO:0061554 name: ganglion formation namespace: biological_process def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "ganglia formation" RELATED [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000045 ! results in formation of anatomical entity ganglion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0061552 ! ganglion morphogenesis relationship: RO:0002297 UBERON:0000045 ! results in formation of anatomical entity ganglion created_by: dph creation_date: 2013-07-10T08:51:50Z [Term] id: GO:0061556 name: trigeminal ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph] synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061559 ! cranial ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis relationship: part_of GO:0061551 ! trigeminal ganglion development relationship: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion created_by: dph creation_date: 2013-07-10T08:57:12Z [Term] id: GO:0061557 name: trigeminal ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] is_a: GO:0061558 ! cranial ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0021635 ! trigeminal nerve maturation relationship: part_of GO:0061551 ! trigeminal ganglion development relationship: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion created_by: dph creation_date: 2013-07-10T08:58:24Z [Term] id: GO:0061558 name: cranial ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] synonym: "cranial ganglia maturation" RELATED [GOC:dph] is_a: GO:0061553 ! ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021605 ! cranial nerve maturation relationship: part_of GO:0061550 ! cranial ganglion development relationship: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion created_by: dph creation_date: 2013-07-10T08:59:52Z [Term] id: GO:0061559 name: cranial ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph] synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061552 ! ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0061550 ! cranial ganglion development relationship: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion created_by: dph creation_date: 2013-07-10T09:02:15Z [Term] id: GO:0061560 name: cranial ganglion formation namespace: biological_process def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "cranial ganglia formation" RELATED [GOC:dph] is_a: GO:0061554 ! ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001714 ! results in formation of anatomical entity cranial ganglion relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0061559 ! cranial ganglion morphogenesis relationship: RO:0002297 UBERON:0001714 ! results in formation of anatomical entity cranial ganglion created_by: dph creation_date: 2013-07-10T09:07:27Z [Term] id: GO:0061561 name: trigeminal ganglion formation namespace: biological_process def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "trigeminal ganglia formation" RELATED [GOC:dph] is_a: GO:0061560 ! cranial ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001675 ! results in formation of anatomical entity trigeminal ganglion relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis relationship: RO:0002297 UBERON:0001675 ! results in formation of anatomical entity trigeminal ganglion created_by: dph creation_date: 2013-07-10T09:08:13Z [Term] id: GO:0061572 name: actin filament bundle organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] synonym: "actin filament cable organization" RELATED [GOC:dph] is_a: GO:0007015 ! actin filament organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032432 ! results in organization of actin filament bundle relationship: RO:0002592 GO:0032432 ! results in organization of actin filament bundle created_by: dph creation_date: 2013-08-02T11:24:11Z [Term] id: GO:0061626 name: pharyngeal arch artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914] synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery relationship: part_of GO:0060037 ! pharyngeal system development relationship: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery created_by: dph creation_date: 2014-05-09T15:34:06Z [Term] id: GO:0061687 name: detoxification of inorganic compound namespace: biological_process def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw] is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: RO:0004009 CHEBI:24835 ! has primary input inorganic molecular entity relationship: RO:0004009 CHEBI:24835 ! has primary input inorganic molecular entity created_by: dph creation_date: 2015-03-09T09:16:23Z [Term] id: GO:0061792 name: secretory granule maturation namespace: biological_process def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] is_a: GO:0033363 ! secretory granule organization is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0030141 ! results in maturation of secretory granule relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002299 GO:0030141 ! results in maturation of secretory granule property_value: RO:0002161 NCBITaxon:4890 created_by: dph creation_date: 2016-09-09T13:24:34Z [Term] id: GO:0061938 name: protein localization to somatodendritic compartment namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993] synonym: "somatodendritic protein localization" EXACT [] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment relationship: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment created_by: dph creation_date: 2017-09-08T13:22:26Z [Term] id: GO:0061951 name: establishment of protein localization to plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] is_a: GO:0072659 ! protein localization to plasma membrane is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane created_by: dph creation_date: 2017-10-26T12:55:15Z [Term] id: GO:0061971 name: replacement bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone relationship: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone created_by: dph creation_date: 2018-02-12T18:10:59Z [Term] id: GO:0061972 name: dermal bone morphogenesis namespace: biological_process def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632] is_a: GO:0061973 ! membrane bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone relationship: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone created_by: dph creation_date: 2018-02-12T18:16:21Z [Term] id: GO:0061973 name: membrane bone morphogenesis namespace: biological_process def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone relationship: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone created_by: dph creation_date: 2018-02-12T18:21:09Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] xref: Reactome:R-HSA-9861718 "Regulation of pyruvate metabolism" is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044281 ! regulates small molecule metabolic process relationship: RO:0002211 GO:0044281 ! regulates small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process relationship: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process relationship: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0062023 name: collagen-containing extracellular matrix namespace: cellular_component def: "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617] subset: gocheck_obsoletion_candidate synonym: "collagen-containing ECM" EXACT [] is_a: GO:0031012 ! extracellular matrix relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29475 xsd:anyURI created_by: dph creation_date: 2018-04-13T12:47:21Z [Term] id: GO:0062033 name: positive regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation relationship: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation created_by: dph creation_date: 2018-04-23T14:32:23Z [Term] id: GO:0062094 name: stomach development namespace: biological_process def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000945 ! results in development of stomach relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of GO:0048565 ! digestive tract development relationship: RO:0002296 UBERON:0000945 ! results in development of stomach created_by: dph creation_date: 2018-11-20T18:15:45Z [Term] id: GO:0062149 name: detection of stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain relationship: part_of GO:0019233 ! sensory perception of pain created_by: dph creation_date: 2019-09-13T13:48:47Z [Term] id: GO:0062237 name: protein localization to postsynapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse relationship: RO:0002339 GO:0098794 ! has target end location postsynapse created_by: dph creation_date: 2020-04-20T13:58:43Z [Term] id: GO:0065002 name: intracellular protein transmembrane transport namespace: biological_process def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "intracellular membrane translocation of a protein" EXACT [] synonym: "intracellular protein membrane transport" EXACT [] synonym: "intracellular protein transport across a membrane" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0071806 ! protein transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 alt_id: GO:0034622 alt_id: GO:0043623 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex relationship: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22580 xsd:anyURI [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_obsoletion_candidate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003674 ! regulates molecular_function relationship: RO:0002211 GO:0003674 ! regulates molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: part_of GO:0005576 ! extracellular region [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043229 ! intracellular organelle relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0070050 name: neuron cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] synonym: "neuron maintenance" EXACT [] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24218 xsd:anyURI [Term] id: GO:0070062 name: extracellular exosome namespace: cellular_component def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] synonym: "exosome" EXACT [GOC:pr] synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle relationship: part_of GO:0005615 ! extracellular space property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0070091 name: glucagon secretion namespace: biological_process def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:5391 ! has primary input glucagon relationship: RO:0004009 CHEBI:5391 ! has primary input glucagon [Term] id: GO:0070092 name: regulation of glucagon secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070091 ! regulates glucagon secretion relationship: RO:0002211 GO:0070091 ! regulates glucagon secretion [Term] id: GO:0070093 name: negative regulation of glucagon secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "down regulation of glucagon secretion" EXACT [] synonym: "down-regulation of glucagon secretion" EXACT [] synonym: "downregulation of glucagon secretion" EXACT [] synonym: "inhibition of glucagon secretion" NARROW [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070091 ! negatively regulates glucagon secretion relationship: RO:0002212 GO:0070091 ! negatively regulates glucagon secretion [Term] id: GO:0070094 name: positive regulation of glucagon secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "activation of glucagon secretion" NARROW [] synonym: "stimulation of glucagon secretion" NARROW [] synonym: "up regulation of glucagon secretion" EXACT [] synonym: "up-regulation of glucagon secretion" EXACT [] synonym: "upregulation of glucagon secretion" EXACT [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070091 ! positively regulates glucagon secretion relationship: RO:0002213 GO:0070091 ! positively regulates glucagon secretion [Term] id: GO:0070161 name: anchoring junction namespace: cellular_component def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] synonym: "anchoring cell junction" EXACT [GOC:mah] is_a: GO:0030054 ! cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0070199 name: establishment of protein localization to chromosome namespace: biological_process def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045184 ! regulates establishment of protein localization relationship: RO:0002211 GO:0045184 ! regulates establishment of protein localization [Term] id: GO:0070202 name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome relationship: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome [Term] id: GO:0070253 name: somatostatin secretion namespace: biological_process def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:64628 ! has primary input somatostatin relationship: RO:0004009 CHEBI:64628 ! has primary input somatostatin [Term] id: GO:0070254 name: mucus secretion namespace: biological_process def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] synonym: "mucus production" EXACT [GOC:add] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 UBERON:0000912 ! has primary input mucus relationship: RO:0004009 UBERON:0000912 ! has primary input mucus property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070255 name: regulation of mucus secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "regulation of mucus production" EXACT [GOC:add] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070254 ! regulates mucus secretion relationship: RO:0002211 GO:0070254 ! regulates mucus secretion [Term] id: GO:0070256 name: negative regulation of mucus secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "negative regulation of mucus production" EXACT [GOC:add] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070254 ! negatively regulates mucus secretion relationship: RO:0002212 GO:0070254 ! negatively regulates mucus secretion [Term] id: GO:0070257 name: positive regulation of mucus secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "positive regulation of mucus production" EXACT [GOC:add] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070254 ! positively regulates mucus secretion relationship: RO:0002213 GO:0070254 ! positively regulates mucus secretion [Term] id: GO:0070278 name: extracellular matrix constituent secretion namespace: biological_process def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] synonym: "ECM constituent secretion" EXACT [GOC:mah] synonym: "ECM secretion" EXACT [GOC:mah] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0030198 ! extracellular matrix organization [Term] id: GO:0070285 name: pigment cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000147 ! results in development of pigment cell relationship: part_of GO:0050931 ! pigment cell differentiation relationship: RO:0002296 CL:0000147 ! results in development of pigment cell [Term] id: GO:0070341 name: fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] synonym: "adipocyte proliferation" EXACT [GOC:sl] synonym: "adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000136 ! acts on population of adipocyte relationship: RO:0012003 CL:0000136 ! acts on population of adipocyte property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070344 name: regulation of fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070341 ! regulates fat cell proliferation relationship: RO:0002211 GO:0070341 ! regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070345 name: negative regulation of fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation relationship: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070346 name: positive regulation of fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation relationship: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070365 name: hepatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] synonym: "liver cell differentiation" EXACT [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000182 ! results in acquisition of features of hepatocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001889 ! liver development relationship: RO:0002315 CL:0000182 ! results in acquisition of features of hepatocyte [Term] id: GO:0070366 name: regulation of hepatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070365 ! regulates hepatocyte differentiation relationship: RO:0002211 GO:0070365 ! regulates hepatocyte differentiation [Term] id: GO:0070367 name: negative regulation of hepatocyte differentiation namespace: biological_process def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070365 ! negatively regulates hepatocyte differentiation relationship: RO:0002212 GO:0070365 ! negatively regulates hepatocyte differentiation [Term] id: GO:0070368 name: positive regulation of hepatocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070365 ! positively regulates hepatocyte differentiation relationship: RO:0002213 GO:0070365 ! positively regulates hepatocyte differentiation [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle is_a: GO:0099503 ! secretory vesicle intersection_of: GO:0030133 ! transport vesicle intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0070483 name: detection of hypoxia namespace: biological_process def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] is_a: GO:0001666 ! response to hypoxia is_a: GO:0003032 ! detection of oxygen [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization relationship: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization [Term] id: GO:0070633 name: transepithelial transport namespace: biological_process def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium relationship: RO:0002342 UBERON:0000483 ! results in transport across epithelium created_by: mah creation_date: 2009-05-06T03:31:02Z [Term] id: GO:0070634 name: transepithelial ammonium transport namespace: biological_process def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] is_a: GO:0070633 ! transepithelial transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0070633 ! transepithelial transport intersection_of: RO:0004009 CHEBI:28938 ! has primary input ammonium relationship: RO:0004009 CHEBI:28938 ! has primary input ammonium created_by: mah creation_date: 2009-05-06T03:34:43Z [Term] id: GO:0070661 name: leukocyte proliferation namespace: biological_process def: "The expansion of a leukocyte population by cell division." [GOC:add] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte created_by: mah creation_date: 2009-05-28T05:25:28Z [Term] id: GO:0070663 name: regulation of leukocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070661 ! regulates leukocyte proliferation relationship: RO:0002211 GO:0070661 ! regulates leukocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-05-28T05:30:39Z [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation relationship: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-05-28T05:34:50Z [Term] id: GO:0070665 name: positive regulation of leukocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation relationship: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-05-28T05:36:46Z [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: mah creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070831 name: basement membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. is_a: GO:0071711 ! basement membrane organization is_a: GO:0085029 ! extracellular matrix assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005604 ! results in assembly of basement membrane relationship: RO:0002588 GO:0005604 ! results in assembly of basement membrane created_by: mah creation_date: 2009-07-23T05:01:51Z [Term] id: GO:0070857 name: regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "regulation of bile acid formation" EXACT [GOC:mah] synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006699 ! regulates bile acid biosynthetic process relationship: RO:0002211 GO:0006699 ! regulates bile acid biosynthetic process created_by: mah creation_date: 2009-08-14T03:09:02Z [Term] id: GO:0070858 name: negative regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process is_a: GO:1904252 ! negative regulation of bile acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006699 ! negatively regulates bile acid biosynthetic process relationship: RO:0002212 GO:0006699 ! negatively regulates bile acid biosynthetic process created_by: mah creation_date: 2009-08-14T03:16:40Z [Term] id: GO:0070859 name: positive regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process is_a: GO:1904253 ! positive regulation of bile acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006699 ! positively regulates bile acid biosynthetic process relationship: RO:0002213 GO:0006699 ! positively regulates bile acid biosynthetic process created_by: mah creation_date: 2009-08-14T03:22:58Z [Term] id: GO:0070873 name: regulation of glycogen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005977 ! regulates glycogen metabolic process relationship: RO:0002211 GO:0005977 ! regulates glycogen metabolic process created_by: mah creation_date: 2009-08-20T02:44:53Z [Term] id: GO:0070874 name: negative regulation of glycogen metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005977 ! negatively regulates glycogen metabolic process relationship: RO:0002212 GO:0005977 ! negatively regulates glycogen metabolic process created_by: mah creation_date: 2009-08-20T02:50:41Z [Term] id: GO:0070875 name: positive regulation of glycogen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005977 ! positively regulates glycogen metabolic process relationship: RO:0002213 GO:0005977 ! positively regulates glycogen metabolic process created_by: mah creation_date: 2009-08-20T02:53:55Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus created_by: mah creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043226 ! results in assembly of organelle relationship: RO:0002588 GO:0043226 ! results in assembly of organelle created_by: mah creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070977 name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0048799 ! animal organ maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001474 ! results in maturation of bone element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060348 ! bone development relationship: RO:0002299 UBERON:0001474 ! results in maturation of bone element created_by: mah creation_date: 2009-10-05T04:35:31Z [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin created_by: mah creation_date: 2009-11-20T11:51:20Z [Term] id: GO:0071169 name: establishment of protein localization to chromatin namespace: biological_process def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin created_by: mah creation_date: 2009-11-20T11:52:43Z [Term] id: GO:0071229 name: cellular response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "cellular response to acid" BROAD [] synonym: "cellular response to acid anion" RELATED [] synonym: "cellular response to oxoanion" RELATED [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0070887 ! cellular response to chemical stimulus created_by: mah creation_date: 2009-12-03T02:07:23Z [Term] id: GO:0071230 name: cellular response to amino acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah] synonym: "cellular response to amino acid" EXACT [GOC:mah] is_a: GO:0043200 ! response to amino acid is_a: GO:0071229 ! cellular response to acid chemical intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion created_by: mah creation_date: 2009-12-03T02:08:11Z [Term] id: GO:0071242 name: cellular response to ammonium ion namespace: biological_process alt_id: GO:1903718 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] synonym: "cellular response to ammonia" EXACT [] is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:28938 ! has primary input ammonium created_by: mah creation_date: 2009-12-03T02:39:40Z [Term] id: GO:0071248 name: cellular response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] synonym: "cellular response to heavy metal" NARROW [GOC:mah] synonym: "cellular response to metal" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion is_a: GO:0070887 ! cellular response to chemical stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25213 ! has primary input metal cation created_by: mah creation_date: 2009-12-03T02:46:31Z [Term] id: GO:0071311 name: cellular response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah] is_a: GO:0010034 ! response to acetate is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate created_by: mah creation_date: 2009-12-10T04:48:16Z [Term] id: GO:0071312 name: cellular response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah] is_a: GO:0043279 ! response to alkaloid is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid created_by: mah creation_date: 2009-12-10T04:50:58Z [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate created_by: mah creation_date: 2009-12-10T05:13:33Z [Term] id: GO:0071326 name: cellular response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0034284 ! response to monosaccharide is_a: GO:0071322 ! cellular response to carbohydrate stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:35381 ! has primary input monosaccharide created_by: mah creation_date: 2009-12-10T05:27:18Z [Term] id: GO:0071331 name: cellular response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] is_a: GO:0009746 ! response to hexose is_a: GO:0071326 ! cellular response to monosaccharide stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18133 ! has primary input hexose created_by: mah creation_date: 2009-12-10T05:37:00Z [Term] id: GO:0071333 name: cellular response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] is_a: GO:0001678 ! intracellular glucose homeostasis is_a: GO:0009749 ! response to glucose is_a: GO:0071331 ! cellular response to hexose stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose created_by: mah creation_date: 2009-12-10T05:38:03Z [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input peptide hormone property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-12-11T03:24:18Z [Term] id: GO:0071377 name: cellular response to glucagon stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah] xref: Reactome:R-HSA-163359 "Glucagon signaling in metabolic regulation" is_a: GO:0033762 ! response to glucagon is_a: GO:0071375 ! cellular response to peptide hormone stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:5391 ! has primary input glucagon property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-12-11T03:25:07Z [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] xref: Reactome:R-HSA-3371497 "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone is_a: GO:0071396 ! cellular response to lipid intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input steroid hormone property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2009-12-11T03:49:02Z [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0070887 ! cellular response to chemical stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid created_by: mah creation_date: 2009-12-11T04:37:10Z [Term] id: GO:0071418 name: cellular response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] is_a: GO:0014075 ! response to amine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine created_by: mah creation_date: 2009-12-14T04:08:17Z [Term] id: GO:0071425 name: hematopoietic stem cell proliferation namespace: biological_process def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl] synonym: "hemopoietic stem cell proliferation" EXACT [] is_a: GO:0072089 ! stem cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0030097 ! hemopoiesis relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell created_by: mah creation_date: 2009-12-16T10:22:52Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-9860931 "Response of endothelial cells to shear stress" is_a: GO:0009719 ! response to endogenous stimulus created_by: mah creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071626 name: mastication namespace: biological_process def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] synonym: "chewing" EXACT [GOC:mah] is_a: GO:0022600 ! digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: mah creation_date: 2010-02-10T11:19:48Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: mah creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure relationship: part_of GO:0048856 ! anatomical structure development relationship: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure created_by: mah creation_date: 2010-03-02T11:43:38Z [Term] id: GO:0071696 name: ectodermal placode development namespace: biological_process def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode created_by: mah creation_date: 2010-03-02T11:48:01Z [Term] id: GO:0071697 name: ectodermal placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0071696 ! ectodermal placode development relationship: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode created_by: mah creation_date: 2010-03-02T11:49:51Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gocheck_obsoletion_candidate is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity created_by: mah creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0016020 ! results in assembly of membrane relationship: part_of GO:0044091 ! membrane biogenesis relationship: RO:0002588 GO:0016020 ! results in assembly of membrane created_by: mah creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071711 name: basement membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. synonym: "basement membrane organisation" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005604 ! results in organization of basement membrane relationship: RO:0002592 GO:0005604 ! results in organization of basement membrane created_by: mah creation_date: 2010-03-10T11:57:10Z [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031965 ! results in organization of nuclear membrane relationship: part_of GO:0006998 ! nuclear envelope organization relationship: RO:0002592 GO:0031965 ! results in organization of nuclear membrane created_by: mah creation_date: 2010-03-29T03:59:35Z [Term] id: GO:0071764 name: nuclear outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane relationship: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane created_by: mah creation_date: 2010-03-29T04:03:37Z [Term] id: GO:0071806 name: protein transmembrane transport namespace: biological_process def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "protein membrane transport" EXACT [] is_a: GO:0015031 ! protein transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein created_by: mah creation_date: 2010-09-03T02:54:26Z [Term] id: GO:0071826 name: protein-RNA complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organization" EXACT [] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex relationship: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/25143 xsd:anyURI created_by: mah creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27189 xsd:anyURI created_by: mah creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071867 name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine relationship: RO:0004009 CHEBI:63534 ! has primary input monoamine created_by: mah creation_date: 2010-09-13T02:36:37Z [Term] id: GO:0071868 name: cellular response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] is_a: GO:0071867 ! response to monoamine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine created_by: mah creation_date: 2010-09-13T02:38:52Z [Term] id: GO:0071869 name: response to catecholamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] synonym: "response to catecholamine stimulus" EXACT [GOC:dos] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine relationship: RO:0004009 CHEBI:33567 ! has primary input catecholamine created_by: mah creation_date: 2010-09-13T02:51:13Z [Term] id: GO:0071870 name: cellular response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:0071869 ! response to catecholamine is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine created_by: mah creation_date: 2010-09-13T02:54:50Z [Term] id: GO:0071873 name: response to norepinephrine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] is_a: GO:0071869 ! response to catecholamine intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) relationship: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) created_by: mah creation_date: 2010-09-13T03:31:53Z [Term] id: GO:0071874 name: cellular response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input (R)-noradrenaline(1+) created_by: mah creation_date: 2010-09-13T03:33:32Z [Term] id: GO:0071887 name: leukocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "leukocyte apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata created_by: mah creation_date: 2010-09-14T12:44:09Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical structure created_by: mah creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071953 name: elastic fiber namespace: cellular_component def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] synonym: "elastic fibre" EXACT [GOC:mah] synonym: "elastin fiber" EXACT [GOC:BHF] is_a: GO:0099512 ! supramolecular fiber relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0031012 ! extracellular matrix created_by: mah creation_date: 2010-10-11T11:44:57Z [Term] id: GO:0071971 name: extracellular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome relationship: part_of GO:0097734 ! extracellular exosome biogenesis relationship: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome property_value: RO:0002161 NCBITaxon:4890 created_by: mah creation_date: 2010-10-18T03:44:18Z [Term] id: GO:0072001 name: renal system development namespace: biological_process def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269] subset: gocheck_do_not_annotate synonym: "urinary system development" BROAD [GOC:yaf] synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] is_a: GO:0048731 ! system development intersection_of: GO:0048731 ! system development intersection_of: RO:0002296 UBERON:0001008 ! results in development of renal system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0001008 ! results in development of renal system created_by: mah creation_date: 2010-01-25T10:31:00Z [Term] id: GO:0072089 name: stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000034 ! acts on population of stem cell relationship: has_part GO:0017145 ! stem cell division relationship: RO:0012003 CL:0000034 ! acts on population of stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2010-02-08T02:03:36Z [Term] id: GO:0072091 name: regulation of stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072089 ! regulates stem cell proliferation relationship: RO:0002211 GO:0072089 ! regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2010-02-08T02:09:03Z [Term] id: GO:0072132 name: mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0060485 ! mesenchyme development relationship: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme created_by: mah creation_date: 2010-02-22T02:17:15Z [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003914 ! results in formation of anatomical entity epithelial tube relationship: part_of GO:0060562 ! epithelial tube morphogenesis relationship: RO:0002297 UBERON:0003914 ! results in formation of anatomical entity epithelial tube property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22302 xsd:anyURI created_by: mah creation_date: 2010-02-26T02:15:40Z [Term] id: GO:0072201 name: negative regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation relationship: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2010-03-01T03:43:29Z [Term] id: GO:0072329 name: monocarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion created_by: mah creation_date: 2010-11-02T04:41:55Z [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion relationship: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion created_by: mah creation_date: 2010-11-02T04:51:32Z [Term] id: GO:0072348 name: sulfur compound transport namespace: biological_process def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity relationship: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity created_by: mah creation_date: 2010-11-11T11:43:56Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process alt_id: GO:0072358 def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] subset: goslim_drosophila synonym: "cardiovascular system development" NARROW [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001009 ! results in development of circulatory system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: RO:0002296 UBERON:0001009 ! results in development of circulatory system created_by: mah creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0072360 name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006965 ! results in development of vascular cord relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0072359 ! circulatory system development relationship: RO:0002296 UBERON:0006965 ! results in development of vascular cord created_by: mah creation_date: 2010-11-16T11:46:55Z [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! transport along microtubule is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0043226 ! has primary input organelle created_by: mah creation_date: 2010-12-01T04:59:11Z [Term] id: GO:0072488 name: ammonium transmembrane transport namespace: biological_process alt_id: GO:0015696 def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ammonia transport" BROAD [] synonym: "ammonium membrane transport" EXACT [] synonym: "ammonium transport" BROAD [] is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0098662 ! inorganic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:28938 ! has primary input ammonium relationship: RO:0004009 CHEBI:28938 ! has primary input ammonium property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22228 xsd:anyURI created_by: mah creation_date: 2010-12-10T10:29:57Z [Term] id: GO:0072560 name: type B pancreatic cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] comment: These processes continue to 60 DPA in Gossypium spp. synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000169 ! results in maturation of type B pancreatic cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003323 ! type B pancreatic cell development relationship: RO:0002299 CL:0000169 ! results in maturation of type B pancreatic cell created_by: mah creation_date: 2011-01-27T01:57:14Z [Term] id: GO:0072575 name: epithelial cell proliferation involved in liver morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0072576 ! liver morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0072576 ! liver morphogenesis created_by: mah creation_date: 2011-02-02T03:37:50Z [Term] id: GO:0072576 name: liver morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002107 ! results in morphogenesis of liver relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0001889 ! liver development relationship: RO:0002298 UBERON:0002107 ! results in morphogenesis of liver created_by: mah creation_date: 2011-02-02T03:41:30Z [Term] id: GO:0072577 name: endothelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] synonym: "endothelial cell apoptosis" NARROW [] synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of endothelial cells" EXACT [GOC:mah] synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000115 ! occurs in endothelial cell relationship: BFO:0000066 CL:0000115 ! occurs in endothelial cell property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2011-02-02T03:56:24Z [Term] id: GO:0072592 name: oxygen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15379 ! has primary input or output dioxygen relationship: RO:0004007 CHEBI:15379 ! has primary input or output dioxygen created_by: mah creation_date: 2011-02-11T10:46:51Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0045184 ! establishment of protein localization intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle created_by: mah creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] subset: goslim_prokaryote synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane created_by: mah creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process alt_id: GO:0072661 alt_id: GO:0090002 def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] subset: goslim_generic subset: goslim_pombe synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "protein localization in plasma membrane" RELATED [] synonym: "protein targeting to plasma membrane" RELATED [] synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane created_by: tb creation_date: 2009-07-10T10:29:23Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002339 GO:0005773 ! has target end location vacuole created_by: mah creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole created_by: mah creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005938 ! has target end location cell cortex relationship: RO:0002339 GO:0005938 ! has target end location cell cortex created_by: mah creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0072698 name: protein localization to microtubule cytoskeleton namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton relationship: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton created_by: mah creation_date: 2012-04-11T01:19:35Z [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044238 ! regulates primary metabolic process relationship: RO:0002211 GO:0044238 ! regulates primary metabolic process created_by: dhl creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006950 ! regulates response to stress relationship: RO:0002211 GO:0006950 ! regulates response to stress created_by: dhl creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080144 name: intracellular amino acid homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell." [PMID:19955263] synonym: "amino acid homeostasis" BROAD [] synonym: "cellular amino acid homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:35238 ! regulates levels of amino-acid zwitterion relationship: RO:0002332 CHEBI:35238 ! regulates levels of amino-acid zwitterion created_by: dhl creation_date: 2010-01-27T04:47:27Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009566 ! regulates fertilization relationship: RO:0002211 GO:0009566 ! regulates fertilization created_by: dhl creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0085029 name: extracellular matrix assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix created_by: jl creation_date: 2010-07-14T12:52:49Z [Term] id: GO:0086001 name: cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell property_value: RO:0002161 NCBITaxon:4895 created_by: tb creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086015 name: SA node cell action potential namespace: biological_process def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell action potential" EXACT [] synonym: "SAN cardiac muscle cell action potential" EXACT [] synonym: "sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node relationship: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signaling property_value: RO:0002161 NCBITaxon:4895 created_by: tb creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0086016 name: AV node cell action potential namespace: biological_process def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node relationship: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling property_value: RO:0002161 NCBITaxon:4895 created_by: tb creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086017 name: Purkinje myocyte action potential namespace: biological_process def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte relationship: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling property_value: RO:0002161 NCBITaxon:4895 created_by: tb creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086018 name: SA node cell to atrial cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW [] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication created_by: tb creation_date: 2011-11-10T09:15:01Z [Term] id: GO:0086019 name: cell-cell signaling involved in cardiac conduction namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0086065 ! cell communication involved in cardiac conduction intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-16T03:43:52Z [Term] id: GO:0086027 name: AV node cell to bundle of His cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node to bundle of His cell signaling" EXACT [] synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086067 ! AV node cell to bundle of His cell communication created_by: tb creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086029 name: Purkinje myocyte to ventricular cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0002068 ! has start location Purkinje myocyte intersection_of: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell relationship: RO:0002231 CL:0002068 ! has start location Purkinje myocyte relationship: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell created_by: tb creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086065 name: cell communication involved in cardiac conduction namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007154 ! cell communication intersection_of: GO:0007154 ! cell communication intersection_of: part_of GO:0061337 ! cardiac conduction relationship: part_of GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-22T08:57:02Z [Term] id: GO:0086067 name: AV node cell to bundle of His cell communication namespace: biological_process def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell to bundle of His cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:11:44Z [Term] id: GO:0086068 name: Purkinje myocyte to ventricular cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:14:49Z [Term] id: GO:0086070 name: SA node cell to atrial cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:32:45Z [Term] id: GO:0090063 name: positive regulation of microtubule nucleation namespace: biological_process def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031116 ! positive regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation relationship: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation created_by: tb creation_date: 2009-08-12T11:33:09Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022402 ! positively regulates cell cycle process relationship: RO:0002213 GO:0022402 ! positively regulates cell cycle process created_by: tb creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090069 name: regulation of ribosome biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042254 ! regulates ribosome biogenesis relationship: RO:0002211 GO:0042254 ! regulates ribosome biogenesis created_by: tb creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090070 name: positive regulation of ribosome biogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis relationship: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis created_by: tb creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090071 name: negative regulation of ribosome biogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis relationship: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis created_by: tb creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015833 ! regulates peptide transport relationship: RO:0002211 GO:0015833 ! regulates peptide transport created_by: tb creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090091 name: positive regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly relationship: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly created_by: tb creation_date: 2009-11-04T10:03:25Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane created_by: tb creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell created_by: tb creation_date: 2009-12-08T08:58:27Z [Term] id: GO:0090166 name: Golgi disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus disassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus relationship: part_of GO:0048313 ! Golgi inheritance relationship: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus created_by: tb creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090168 name: Golgi reassembly namespace: biological_process def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus reassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0048313 ! Golgi inheritance created_by: tb creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090170 name: regulation of Golgi inheritance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048313 ! regulates Golgi inheritance relationship: RO:0002211 GO:0048313 ! regulates Golgi inheritance created_by: tb creation_date: 2009-12-11T10:21:59Z [Term] id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000138 ! results in maturation of chondrocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0002063 ! chondrocyte development relationship: RO:0002299 CL:0000138 ! results in maturation of chondrocyte created_by: tb creation_date: 2009-12-11T10:36:02Z [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048284 ! organelle fusion is_a: GO:0061025 ! membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031090 ! results in fusion of organelle membrane relationship: RO:0012008 GO:0031090 ! results in fusion of organelle membrane created_by: tb creation_date: 2009-12-11T11:44:58Z [Term] id: GO:0090257 name: regulation of muscle system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003012 ! regulates muscle system process relationship: RO:0002211 GO:0003012 ! regulates muscle system process created_by: tb creation_date: 2010-02-03T11:48:13Z [Term] id: GO:0090273 name: regulation of somatostatin secretion namespace: biological_process def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070253 ! regulates somatostatin secretion relationship: RO:0002211 GO:0070253 ! regulates somatostatin secretion created_by: tb creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090274 name: positive regulation of somatostatin secretion namespace: biological_process def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070253 ! positively regulates somatostatin secretion relationship: RO:0002213 GO:0070253 ! positively regulates somatostatin secretion created_by: tb creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090275 name: negative regulation of somatostatin secretion namespace: biological_process def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070253 ! negatively regulates somatostatin secretion relationship: RO:0002212 GO:0070253 ! negatively regulates somatostatin secretion created_by: tb creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090276 name: regulation of peptide hormone secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030072 ! regulates peptide hormone secretion relationship: RO:0002211 GO:0030072 ! regulates peptide hormone secretion created_by: tb creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090277 name: positive regulation of peptide hormone secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion relationship: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion created_by: tb creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090278 name: negative regulation of peptide hormone secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion relationship: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion created_by: tb creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090299 name: regulation of neural crest formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014029 ! regulates neural crest formation relationship: RO:0002211 GO:0014029 ! regulates neural crest formation created_by: tb creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090300 name: positive regulation of neural crest formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014029 ! positively regulates neural crest formation relationship: RO:0002213 GO:0014029 ! positively regulates neural crest formation created_by: tb creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090301 name: negative regulation of neural crest formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014029 ! negatively regulates neural crest formation relationship: RO:0002212 GO:0014029 ! negatively regulates neural crest formation created_by: tb creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid relationship: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26133 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27052 xsd:anyURI created_by: tb creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport relationship: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport relationship: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031987 ! regulates locomotion involved in locomotory behavior relationship: RO:0002211 GO:0031987 ! regulates locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:24:29Z [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002213 GO:0031987 ! positively regulates locomotion involved in locomotory behavior relationship: RO:0002213 GO:0031987 ! positively regulates locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031987 ! negatively regulates locomotion involved in locomotory behavior relationship: RO:0002212 GO:0031987 ! negatively regulates locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090425 name: acinar cell differentiation namespace: biological_process def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] is_a: GO:0002067 ! glandular epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell relationship: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell created_by: tb creation_date: 2012-05-04T09:24:48Z [Term] id: GO:0090435 name: protein localization to nuclear envelope namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] synonym: "protein localization in nuclear envelope" EXACT [] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005635 ! has target end location nuclear envelope relationship: RO:0002339 GO:0005635 ! has target end location nuclear envelope created_by: tb creation_date: 2012-07-30T01:50:41Z [Term] id: GO:0090493 name: catecholamine uptake namespace: biological_process def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure created_by: tb creation_date: 2012-10-17T11:06:17Z [Term] id: GO:0090596 name: sensory organ morphogenesis namespace: biological_process def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ relationship: part_of GO:0007423 ! sensory organ development relationship: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ created_by: tb creation_date: 2014-08-22T13:23:20Z [Term] id: GO:0090685 name: RNA localization to nucleus namespace: biological_process def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] synonym: "RNA localisation to nucleus" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus created_by: tb creation_date: 2016-07-19T17:00:49Z [Term] id: GO:0090741 name: pigment granule membrane namespace: cellular_component def: "Any membrane that is part of a pigment granule." [PMID:11294610] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0048770 ! pigment granule relationship: bounding_layer_of GO:0048770 ! pigment granule relationship: part_of GO:0048770 ! pigment granule created_by: tb creation_date: 2017-05-16T22:33:39Z [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005929 ! cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005929 ! cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: pr creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097049 name: motor neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086] synonym: "motoneuron apoptosis" EXACT [] synonym: "motor neuron apoptosis" NARROW [] is_a: GO:0051402 ! neuron apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000100 ! occurs in motor neuron relationship: BFO:0000066 CL:0000100 ! occurs in motor neuron property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-04T02:21:43Z [Term] id: GO:0097050 name: type B pancreatic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305] synonym: "pancreatic B cell apoptosis" EXACT [] synonym: "pancreatic beta cell apoptosis" EXACT [] synonym: "type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000169 ! occurs in type B pancreatic cell relationship: BFO:0000066 CL:0000169 ! occurs in type B pancreatic cell property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-05-04T02:24:38Z [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] subset: goslim_synapse is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0045202 ! synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0045202 ! synapse created_by: pr creation_date: 2011-06-07T11:22:09Z [Term] id: GO:0097084 name: vascular associated smooth muscle cell development namespace: biological_process def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] synonym: "vascular smooth muscle cell development" EXACT [] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation relationship: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell created_by: pr creation_date: 2011-06-20T04:03:08Z [Term] id: GO:0097152 name: mesenchymal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833] synonym: "mesenchymal cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell relationship: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-09-06T02:31:59Z [Term] id: GO:0097164 name: ammonium ion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018] synonym: "ammonium ion metabolism" EXACT [] synonym: "ammonium metabolic process" RELATED [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28938 ! has primary input or output ammonium relationship: RO:0004007 CHEBI:28938 ! has primary input or output ammonium created_by: pr creation_date: 2011-09-28T04:21:30Z [Term] id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process alt_id: GO:0008624 def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] xref: Reactome:R-HSA-193681 "Ceramide signalling" xref: Reactome:R-HSA-204998 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:R-HSA-75157 "FasL/ CD95L signaling" is_a: GO:0007165 ! signal transduction relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: part_of GO:0006915 ! apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-11-23T09:30:23Z [Term] id: GO:0097194 name: execution phase of apoptosis namespace: biological_process def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] synonym: "apoptosis" NARROW [] synonym: "execution phase of apoptotic process" EXACT [] xref: Reactome:R-HSA-75153 "Apoptotic execution phase" is_a: GO:0009987 ! cellular process relationship: has_part GO:0032060 ! bleb assembly relationship: in_taxon NCBITaxon:33154 ! Opisthokonta relationship: part_of GO:0006915 ! apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-11-23T09:45:24Z [Term] id: GO:0097237 name: cellular response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] is_a: GO:0009636 ! response to toxic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: pr creation_date: 2012-02-02T12:23:31Z [Term] id: GO:0097254 name: renal tubular secretion namespace: biological_process def: "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22368 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: pr creation_date: 2012-03-05T02:03:58Z [Term] id: GO:0097272 name: ammonium homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560] synonym: "ammonia homeostasis" EXACT [] is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:28938 ! regulates levels of ammonium relationship: RO:0002332 CHEBI:28938 ! regulates levels of ammonium created_by: pr creation_date: 2012-03-22T02:51:22Z [Term] id: GO:0097275 name: intracellular ammonium homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell." [GOC:yaf, PMID:12695560] synonym: "cellular ammonia homeostasis" EXACT [] synonym: "cellular ammonium homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis is_a: GO:0097272 ! ammonium homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:28938 ! regulates levels of ammonium created_by: pr creation_date: 2012-03-22T02:54:38Z [Term] id: GO:0097284 name: hepatocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020] synonym: "hepatocyte apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000182 ! occurs in hepatocyte relationship: BFO:0000066 CL:0000182 ! occurs in hepatocyte property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2012-03-29T10:23:21Z [Term] id: GO:0097355 name: protein localization to heterochromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0000792 ! has target end location heterochromatin relationship: RO:0002339 GO:0000792 ! has target end location heterochromatin created_by: pr creation_date: 2012-07-03T03:19:07Z [Term] id: GO:0097386 name: glial cell projection namespace: cellular_component def: "A prolongation or process extending from a glial cell." [GOC:mc] synonym: "glial process" RELATED [] synonym: "glial projection" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: part_of CL:0000125 ! glial cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000125 ! glial cell created_by: pr creation_date: 2012-10-22T13:55:54Z [Term] id: GO:0097427 name: microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] synonym: "microtubule fascicle" EXACT [] xref: NIF_Subcellular:sao1872343973 is_a: GO:0110165 ! cellular anatomical structure relationship: has_part GO:0005874 ! microtubule relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005856 ! cytoskeleton created_by: pr creation_date: 2012-11-07T15:01:27Z [Term] id: GO:0097435 name: supramolecular fiber organization namespace: biological_process alt_id: GO:0043206 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] synonym: "extracellular fibril organisation" NARROW [] synonym: "extracellular fibril organization" NARROW [] synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] synonym: "fibril organisation" RELATED [] synonym: "fibril organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber relationship: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber created_by: pr creation_date: 2012-11-27T15:46:25Z [Term] id: GO:0097473 name: retinal rod cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487] synonym: "rod photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000604 ! occurs in retinal rod cell relationship: BFO:0000066 CL:0000604 ! occurs in retinal rod cell property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2013-03-21T09:44:45Z [Term] id: GO:0097474 name: retinal cone cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc] synonym: "cone photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000573 ! occurs in retinal cone cell relationship: BFO:0000066 CL:0000573 ! occurs in retinal cone cell property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2013-03-21T09:46:22Z [Term] id: GO:0097512 name: cardiac myofibril namespace: cellular_component def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: part_of CL:0000746 ! cardiac muscle cell relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of CL:0000746 ! cardiac muscle cell created_by: pr creation_date: 2013-10-16T13:04:58Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole relationship: RO:0012008 GO:0005773 ! results in fusion of vacuole created_by: pr creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005622 ! intracellular anatomical structure created_by: pr creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097711 name: ciliary basal body-plasma membrane docking namespace: biological_process def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235] comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. synonym: "anchoring of the basal body to the plasma membrane" RELATED [] synonym: "ciliary basal body docking" EXACT [] xref: Reactome:R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0060271 ! cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: pr creation_date: 2016-08-05T16:12:33Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0060271 ! cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: pr creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097734 name: extracellular exosome biogenesis namespace: biological_process def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] synonym: "exosome assembly or secretion" EXACT [] synonym: "exosome biogenesis" EXACT [] synonym: "exosome production" EXACT [] synonym: "ILV assembly" RELATED [] synonym: "intraluminal vesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis created_by: pr creation_date: 2016-10-03T14:35:25Z [Term] id: GO:0098523 name: neuromuscular junction of myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. is_a: GO:0031594 ! neuromuscular junction intersection_of: GO:0045202 ! synapse intersection_of: overlaps CL:0000100 ! motor neuron intersection_of: overlaps CL:0002372 ! myotube relationship: overlaps CL:0002372 ! myotube created_by: dos creation_date: 2013-10-14T12:05:12Z [Term] id: GO:0098528 name: skeletal muscle fiber differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos] is_a: GO:0014902 ! myotube differentiation is_a: GO:0035914 ! skeletal muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber relationship: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber created_by: dos creation_date: 2013-10-15T14:00:34Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0043226 ! organelle relationship: bounding_layer_of GO:0043226 ! organelle created_by: dos creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane created_by: dos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098642 name: network-forming collagen trimer namespace: cellular_component def: "A collagen trimer that forms networks." [PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098645 ! collagen network relationship: part_of GO:0098645 ! collagen network [Term] id: GO:0098643 name: banded collagen fibril namespace: cellular_component def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers is_a: GO:0099512 ! supramolecular fiber [Term] id: GO:0098644 name: complex of collagen trimers namespace: cellular_component def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos] synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541] synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911] is_a: GO:0099080 ! supramolecular complex relationship: has_part GO:0005581 ! collagen trimer relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0098645 name: collagen network namespace: cellular_component def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers is_a: GO:0099081 ! supramolecular polymer [Term] id: GO:0098655 name: monoatomic cation transmembrane transport namespace: biological_process alt_id: GO:0099132 def: "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw] synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW [] synonym: "cation transmembrane transport" BROAD [] is_a: GO:0006812 ! monoatomic cation transport is_a: GO:0034220 ! monoatomic ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:23906 ! has primary input monoatomic cation [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005737 ! has target end location cytoplasm intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005737 ! has target end location cytoplasm relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity [Term] id: GO:0098660 name: inorganic ion transmembrane transport namespace: biological_process def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic ion membrane transport" EXACT [] synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36914 ! has primary input inorganic ion relationship: RO:0004009 CHEBI:36914 ! has primary input inorganic ion [Term] id: GO:0098661 name: inorganic anion transmembrane transport namespace: biological_process def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic anion membrane transport" EXACT [] synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0098660 ! inorganic ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:24834 ! has primary input inorganic anion [Term] id: GO:0098662 name: inorganic cation transmembrane transport namespace: biological_process alt_id: GO:0015672 alt_id: GO:0072511 def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "divalent inorganic cation transport" NARROW [] synonym: "inorganic cation membrane transport" EXACT [] synonym: "monovalent inorganic cation transport" NARROW [] synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0098660 ! inorganic ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36915 ! has primary input inorganic cation relationship: RO:0004009 CHEBI:36915 ! has primary input inorganic cation [Term] id: GO:0098722 name: asymmetric stem cell division namespace: biological_process def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0017145 ! stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0098723 name: skeletal muscle myofibril namespace: cellular_component def: "A myofibril of a skeletal muscle fiber." [GOC:dos] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: part_of CL:0008002 ! skeletal muscle fiber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of CL:0008002 ! skeletal muscle fiber [Term] id: GO:0098728 name: germline stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] is_a: GO:0042078 ! germ-line stem cell division is_a: GO:0098722 ! asymmetric stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0098751 name: bone cell development namespace: biological_process def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. subset: gocheck_do_not_annotate is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0001035 ! results in development of bone cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060348 ! bone development relationship: RO:0002296 CL:0001035 ! results in development of bone cell [Term] id: GO:0098754 name: detoxification namespace: biological_process def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon is_a: GO:0008150 ! biological_process relationship: part_of GO:0009636 ! response to toxic substance [Term] id: GO:0098771 name: inorganic ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos] subset: goslim_pombe is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0042592 ! homeostatic process intersection_of: RO:0002332 CHEBI:36914 ! regulates levels of inorganic ion relationship: RO:0002332 CHEBI:36914 ! regulates levels of inorganic ion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24455 xsd:anyURI [Term] id: GO:0098773 name: skin epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos] is_a: GO:0008544 ! epidermis development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001003 ! results in development of skin epidermis relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of GO:0043588 ! skin development relationship: RO:0002296 UBERON:0001003 ! results in development of skin epidermis [Term] id: GO:0098793 name: presynapse namespace: cellular_component def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos] subset: goslim_synapse synonym: "presynaptic terminal" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000540 ! neuron relationship: part_of GO:0045202 ! synapse [Term] id: GO:0098794 name: postsynapse namespace: cellular_component def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical structure relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of CL:0000000 ! cell relationship: part_of GO:0045202 ! synapse [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0098801 name: regulation of renal system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003014 ! regulates renal system process relationship: RO:0002211 GO:0003014 ! regulates renal system process [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0098858 name: actin-based cell projection namespace: cellular_component def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0005884 ! actin filament [Term] id: GO:0098867 name: intramembranous bone growth namespace: biological_process def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone relationship: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone [Term] id: GO:0098868 name: bone growth namespace: biological_process def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001474 ! results in growth of bone element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060348 ! bone development relationship: RO:0002343 UBERON:0001474 ! results in growth of bone element [Term] id: GO:0098871 name: postsynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse [Term] id: GO:0098876 name: vesicle-mediated transport to the plasma membrane namespace: biological_process def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0051668 ! localization within membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: ends_with GO:0006887 ! exocytosis relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane [Term] id: GO:0098883 name: synapse pruning namespace: biological_process def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190] subset: goslim_synapse synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716] synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020] synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190] synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716] is_a: GO:0050808 ! synapse organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0045202 ! results in disassembly of synapse relationship: RO:0002590 GO:0045202 ! results in disassembly of synapse [Term] id: GO:0098900 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0001508 ! regulates action potential relationship: RO:0002211 GO:0001508 ! regulates action potential [Term] id: GO:0098901 name: regulation of cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential relationship: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential [Term] id: GO:0098904 name: regulation of AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086016 ! regulates AV node cell action potential relationship: RO:0002211 GO:0086016 ! regulates AV node cell action potential created_by: tb creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098906 name: regulation of Purkinje myocyte action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential relationship: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential created_by: tb creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098907 name: regulation of SA node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086015 ! regulates SA node cell action potential relationship: RO:0002211 GO:0086015 ! regulates SA node cell action potential created_by: tb creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0098908 name: regulation of neuronal action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0051969 ! regulation of transmission of nerve impulse is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0019228 ! regulates neuronal action potential relationship: RO:0002211 GO:0019228 ! regulates neuronal action potential [Term] id: GO:0098916 name: anterograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098793 ! has start location presynapse intersection_of: RO:0002232 GO:0098794 ! has end location postsynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002232 GO:0098794 ! has end location postsynapse [Term] id: GO:0098917 name: retrograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse relationship: RO:0002231 GO:0098794 ! has start location postsynapse relationship: RO:0002232 GO:0098793 ! has end location presynapse [Term] id: GO:0098920 name: retrograde trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099541 ! trans-synaptic signaling by lipid intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0098926 name: postsynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0099536 ! synaptic signaling relationship: RO:0002231 GO:0098794 ! has start location postsynapse [Term] id: GO:0098928 name: presynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse [Term] id: GO:0098974 name: postsynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton relationship: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton [Term] id: GO:0098975 name: postsynapse of neuromuscular junction namespace: cellular_component def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502] is_a: GO:0098794 ! postsynapse intersection_of: GO:0098794 ! postsynapse intersection_of: part_of CL:0000187 ! muscle cell intersection_of: part_of GO:0031594 ! neuromuscular junction relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000187 ! muscle cell relationship: part_of GO:0031594 ! neuromuscular junction [Term] id: GO:0098981 name: cholinergic synapse namespace: cellular_component def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: capable_of GO:0007271 ! synaptic transmission, cholinergic relationship: capable_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0098992 name: neuronal dense core vesicle namespace: cellular_component def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] subset: goslim_synapse is_a: GO:0031045 ! dense core granule intersection_of: GO:0031045 ! dense core granule intersection_of: part_of CL:0000540 ! neuron relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of CL:0000540 ! neuron [Term] id: GO:0099003 name: vesicle-mediated transport in synapse namespace: biological_process def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0099012 name: neuronal dense core vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] subset: goslim_synapse is_a: GO:0032127 ! dense core granule membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0098992 ! neuronal dense core vesicle relationship: bounding_layer_of GO:0098992 ! neuronal dense core vesicle relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0098992 ! neuronal dense core vesicle [Term] id: GO:0099014 name: neuronal dense core vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] is_a: GO:0061109 ! dense core granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle relationship: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle [Term] id: GO:0099054 name: presynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494] subset: goslim_synapse synonym: "presynapse biogenesis" EXACT [GOC:mah] synonym: "presynaptic terminal assembly" EXACT [PMID:24449494] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099172 ! presynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098793 ! results in assembly of presynapse relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007416 ! synapse assembly relationship: RO:0002588 GO:0098793 ! results in assembly of presynapse [Term] id: GO:0099068 name: postsynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL] synonym: "postsynapse biogenesis" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099173 ! postsynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098794 ! results in assembly of postsynapse relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0007416 ! synapse assembly relationship: RO:0002588 GO:0098794 ! results in assembly of postsynapse [Term] id: GO:0099080 name: supramolecular complex namespace: cellular_component def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0099081 name: supramolecular polymer namespace: cellular_component def: "A polymeric supramolecular structure." [GOC:dos] is_a: GO:0099080 ! supramolecular complex intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: RO:0000053 PATO:0015006 ! has characteristic polymeric [Term] id: GO:0099082 name: retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099083 name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099098 name: microtubule polymerization based movement namespace: biological_process def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194] is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: has_part GO:0046785 ! microtubule polymerization relationship: has_part GO:0046785 ! microtubule polymerization relationship: in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule [Term] id: GO:0099112 name: microtubule polymerization based protein transport namespace: biological_process def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: has_part GO:0046785 ! microtubule polymerization intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: has_part GO:0046785 ! microtubule polymerization [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0007017 ! microtubule-based process is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099140 name: presynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099187 ! presynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton relationship: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton created_by: dos creation_date: 2017-06-09T18:34:19Z [Term] id: GO:0099143 name: presynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: part_of GO:0098793 ! presynapse created_by: dos creation_date: 2017-06-09T18:36:19Z [Term] id: GO:0099156 name: cell-cell signaling via exosome namespace: biological_process def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038] synonym: "exosome mediated" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome relationship: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome created_by: dos creation_date: 2017-07-05T16:40:45Z [Term] id: GO:0099157 name: trans-synaptic signaling via exosome namespace: biological_process def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] subset: goslim_synapse synonym: "exosome mediated transynaptic signalling" EXACT [] synonym: "trans-synaptic signalling via exosome" EXACT [] is_a: GO:0099156 ! cell-cell signaling via exosome is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome created_by: dos creation_date: 2017-07-05T16:49:44Z [Term] id: GO:0099170 name: postsynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse created_by: dos creation_date: 2017-09-11T17:09:17Z [Term] id: GO:0099171 name: presynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse created_by: dos creation_date: 2017-09-11T17:09:31Z [Term] id: GO:0099172 name: presynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynapse development" EXACT [] synonym: "presynapse morphogenesis" RELATED [GOC:BHF] synonym: "presynapse organisation" EXACT [] synonym: "presynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098793 ! results in organization of presynapse relationship: part_of GO:0050808 ! synapse organization relationship: RO:0002592 GO:0098793 ! results in organization of presynapse [Term] id: GO:0099173 name: postsynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynapse development" EXACT [] synonym: "postsynapse morphogenesis" RELATED [GOC:BHF] synonym: "postsynapse organisation" EXACT [] synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098794 ! results in organization of postsynapse relationship: part_of GO:0050808 ! synapse organization relationship: RO:0002592 GO:0098794 ! results in organization of postsynapse [Term] id: GO:0099174 name: regulation of presynapse organization namespace: biological_process def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of presynapse organisation" EXACT [GOC:mah] synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of presynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099172 ! regulates presynapse organization relationship: RO:0002211 GO:0099172 ! regulates presynapse organization [Term] id: GO:0099175 name: regulation of postsynapse organization namespace: biological_process def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of postsynapse organisation" EXACT [GOC:mah] synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of postsynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099173 ! regulates postsynapse organization relationship: RO:0002211 GO:0099173 ! regulates postsynapse organization [Term] id: GO:0099177 name: regulation of trans-synaptic signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling relationship: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling [Term] id: GO:0099187 name: presynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos] is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton relationship: part_of GO:0099172 ! presynapse organization relationship: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton created_by: dos creation_date: 2017-12-20T15:05:34Z [Term] id: GO:0099188 name: postsynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton relationship: part_of GO:0099173 ! postsynapse organization relationship: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton created_by: dos creation_date: 2017-12-20T15:06:57Z [Term] id: GO:0099500 name: vesicle fusion to plasma membrane namespace: biological_process def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] is_a: GO:0006906 ! vesicle fusion is_a: GO:0140029 ! exocytic process intersection_of: GO:0061025 ! membrane fusion intersection_of: part_of GO:0006887 ! exocytosis intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane intersection_of: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region relationship: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region [Term] id: GO:0099501 name: exocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030658 ! transport vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0070382 ! exocytic vesicle relationship: bounding_layer_of GO:0070382 ! exocytic vesicle relationship: part_of GO:0070382 ! exocytic vesicle [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0031982 ! vesicle intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane relationship: capable_of GO:0099500 ! vesicle fusion to plasma membrane [Term] id: GO:0099512 name: supramolecular fiber namespace: cellular_component alt_id: GO:0043205 def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] synonym: "fibril" RELATED [] is_a: GO:0099081 ! supramolecular polymer intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0002309 ! has characteristic fiber shaped intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: RO:0000053 PATO:0002309 ! has characteristic fiber shaped [Term] id: GO:0099513 name: polymeric cytoskeletal fiber namespace: cellular_component def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] is_a: GO:0099512 ! supramolecular fiber intersection_of: GO:0099512 ! supramolecular fiber intersection_of: part_of GO:0005856 ! cytoskeleton intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0099515 name: actin filament-based transport namespace: biological_process def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament relationship: RO:0002341 GO:0005884 ! results in transport along actin filament created_by: tb creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0099518 name: vesicle cytoskeletal trafficking namespace: biological_process def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl] synonym: "vesicle cytoskeletal transport" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0099531 name: presynaptic process involved in chemical synaptic transmission namespace: biological_process def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: part_of GO:0007268 ! chemical synaptic transmission relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099536 name: synaptic signaling namespace: biological_process def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] subset: goslim_drosophila subset: goslim_synapse is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa [Term] id: GO:0099537 name: trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099538 name: synaptic signaling via neuropeptide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling intersection_of: GO:0099536 ! synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion relationship: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099540 name: trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling is_a: GO:0099538 ! synaptic signaling via neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099541 name: trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid relationship: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0099546 name: protein catabolic process, modulating synaptic transmission namespace: biological_process def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099547 name: regulation of translation at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099550 name: trans-synaptic signaling, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099551 name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099552 name: trans-synaptic signaling by lipid, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099541 ! trans-synaptic signaling by lipid is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0099569 name: presynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0098793 ! presynapse relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0099571 name: postsynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099574 name: regulation of protein catabolic process at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein [Term] id: GO:0099575 name: regulation of protein catabolic process at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099576 name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099577 name: regulation of translation at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140244 ! regulation of translation at presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099578 name: regulation of translation at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140245 ! regulation of translation at postsynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099632 name: protein transport within plasma membrane namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005886 ! occurs in plasma membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000066 GO:0005886 ! occurs in plasma membrane [Term] id: GO:0099640 name: axo-dendritic protein transport namespace: biological_process def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axonal protein transport" NARROW [] is_a: GO:0008088 ! axo-dendritic transport is_a: GO:0098840 ! protein transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099643 name: signal release from synapse namespace: biological_process def: "Any signal release from a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0023061 ! signal release intersection_of: GO:0023061 ! signal release intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0099536 ! synaptic signaling [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] subset: gocheck_do_not_annotate synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0100001 name: regulation of skeletal muscle contraction by action potential namespace: biological_process def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol] is_a: GO:0001508 ! action potential is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0001508 ! action potential intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction property_value: RO:0002161 NCBITaxon:4895 created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0101023 name: vascular endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774] is_a: GO:0001935 ! endothelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell relationship: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0101024 name: mitotic nuclear membrane organization namespace: biological_process def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872] comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT [] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19949 xsd:anyURI [Term] id: GO:0101025 name: nuclear membrane biogenesis namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0031965 ! has primary output nuclear membrane relationship: part_of GO:0071763 ! nuclear membrane organization relationship: RO:0004008 GO:0031965 ! has primary output nuclear membrane [Term] id: GO:0106027 name: neuron projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043005 ! results in organization of neuron projection relationship: RO:0002592 GO:0043005 ! results in organization of neuron projection created_by: hjd creation_date: 2017-06-23T18:30:18Z [Term] id: GO:0106214 name: regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus relationship: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:12:22Z [Term] id: GO:0106215 name: negative regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus relationship: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:17:17Z [Term] id: GO:0106216 name: positive regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus relationship: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:20:59Z [Term] id: GO:0110011 name: regulation of basement membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071711 ! regulates basement membrane organization relationship: RO:0002211 GO:0071711 ! regulates basement membrane organization created_by: kmv [Term] id: GO:0110020 name: regulation of actomyosin structure organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031032 ! regulates actomyosin structure organization relationship: RO:0002211 GO:0031032 ! regulates actomyosin structure organization created_by: kmv creation_date: 2017-06-20T19:28:58Z [Term] id: GO:0110021 name: cardiac muscle myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0051450 ! myoblast proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast relationship: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast property_value: RO:0002161 NCBITaxon:4751 created_by: kmv creation_date: 2017-06-29T14:35:24Z [Term] id: GO:0110022 name: regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation relationship: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: kmv creation_date: 2017-06-29T15:11:47Z [Term] id: GO:0110023 name: negative regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000818 ! negative regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation relationship: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: kmv creation_date: 2017-06-29T15:18:30Z [Term] id: GO:0110024 name: positive regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000288 ! positive regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation relationship: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: kmv creation_date: 2017-06-29T15:24:16Z [Term] id: GO:0110053 name: regulation of actin filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007015 ! regulates actin filament organization relationship: RO:0002211 GO:0007015 ! regulates actin filament organization created_by: kmv creation_date: 2017-09-20T19:52:57Z [Term] id: GO:0110057 name: regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation relationship: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:32:09Z [Term] id: GO:0110058 name: positive regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045603 ! positive regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation relationship: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:38:19Z [Term] id: GO:0110059 name: negative regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation relationship: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:47:29Z [Term] id: GO:0110077 name: vesicle-mediated intercellular transport namespace: biological_process def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] synonym: "endosomal trafficking" RELATED [] is_a: GO:0010496 ! intercellular transport is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0010496 ! intercellular transport intersection_of: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle relationship: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle created_by: kmv creation_date: 2018-01-29T14:46:52Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis relationship: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis relationship: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110113 name: positive regulation of lipid transporter activity namespace: biological_process def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] subset: gocheck_obsoletion_candidate is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032411 ! positive regulation of transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005319 ! positively regulates lipid transporter activity relationship: RO:0002213 GO:0005319 ! positively regulates lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:14:13Z [Term] id: GO:0110114 name: negative regulation of lipid transporter activity namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] subset: gocheck_obsoletion_candidate is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032410 ! negative regulation of transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005319 ! negatively regulates lipid transporter activity relationship: RO:0002212 GO:0005319 ! negatively regulates lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:21:44Z [Term] id: GO:0110116 name: regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation relationship: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:08:49Z [Term] id: GO:0110117 name: positive regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation relationship: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:13:28Z [Term] id: GO:0110118 name: negative regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation relationship: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:15:52Z [Term] id: GO:0110165 name: cellular anatomical structure namespace: cellular_component def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular anatomical entity" EXACT [] is_a: CARO:0000000 ! anatomical entity is_a: GO:0005575 ! cellular_component is_a: UBERON:0000061 ! anatomical structure property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24200 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/26424 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28978 xsd:anyURI created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: has_part GO:0098590 ! plasma membrane region relationship: has_part GO:0098590 ! plasma membrane region property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13193 xsd:anyURI created_by: krc creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection relationship: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly relationship: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly relationship: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly relationship: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization relationship: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection relationship: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120039 name: plasma membrane bounded cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] is_a: GO:0048858 ! cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection relationship: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-28T23:39:37Z [Term] id: GO:0120111 name: neuron projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0043005 ! neuron projection relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of GO:0043005 ! neuron projection property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14472 xsd:anyURI created_by: krc creation_date: 2017-11-01T18:58:12Z [Term] id: GO:0120158 name: positive regulation of collagen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010714 ! positive regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process relationship: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15720 xsd:anyURI created_by: krc creation_date: 2018-05-11T16:31:42Z [Term] id: GO:0120178 name: steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] is_a: GO:0006694 ! steroid biosynthetic process intersection_of: GO:0006694 ! steroid biosynthetic process intersection_of: RO:0004008 CHEBI:26764 ! has primary output steroid hormone relationship: RO:0004008 CHEBI:26764 ! has primary output steroid hormone property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16000 xsd:anyURI created_by: krc creation_date: 2019-05-20T22:34:00Z [Term] id: GO:0120186 name: negative regulation of protein localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin relationship: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16012 xsd:anyURI created_by: krc creation_date: 2018-07-14T00:19:32Z [Term] id: GO:0120187 name: positive regulation of protein localization to chromatin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin relationship: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16012 xsd:anyURI created_by: krc creation_date: 2018-07-14T00:21:28Z [Term] id: GO:0120188 name: regulation of bile acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032782 ! regulates bile acid secretion relationship: RO:0002211 GO:0032782 ! regulates bile acid secretion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI created_by: krc creation_date: 2018-07-16T22:28:58Z [Term] id: GO:0120189 name: positive regulation of bile acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032782 ! positively regulates bile acid secretion relationship: RO:0002213 GO:0032782 ! positively regulates bile acid secretion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI created_by: krc creation_date: 2018-07-16T22:36:17Z [Term] id: GO:0120190 name: negative regulation of bile acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032782 ! negatively regulates bile acid secretion relationship: RO:0002212 GO:0032782 ! negatively regulates bile acid secretion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI created_by: krc creation_date: 2018-07-16T22:38:34Z [Term] id: GO:0120222 name: regulation of blastocyst development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001824 ! regulates blastocyst development relationship: RO:0002211 GO:0001824 ! regulates blastocyst development property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18871 xsd:anyURI created_by: krc creation_date: 2020-02-17T19:59:20Z [Term] id: GO:0120305 name: regulation of pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043473 ! regulates pigmentation relationship: RO:0002211 GO:0043473 ! regulates pigmentation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20524 xsd:anyURI created_by: krc creation_date: 2021-02-09T19:37:35Z [Term] id: GO:0120331 name: endothelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824] is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003915 ! results in formation of anatomical entity endothelial tube relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0061154 ! endothelial tube morphogenesis relationship: RO:0002297 UBERON:0003915 ! results in formation of anatomical entity endothelial tube property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22302 xsd:anyURI created_by: krc creation_date: 2022-05-25T16:17:59Z [Term] id: GO:0140001 name: morula formation namespace: biological_process def: "The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000085 ! results in formation of anatomical entity morula relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0002297 UBERON:0000085 ! results in formation of anatomical entity morula property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29162 xsd:anyURI created_by: pg creation_date: 2024-11-12T09:29:56Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] subset: goslim_generic synonym: "meiosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19910 xsd:anyURI created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19910 xsd:anyURI created_by: pg creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140029 name: exocytic process namespace: biological_process def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0006887 ! exocytosis relationship: part_of GO:0006887 ! exocytosis created_by: pg creation_date: 2017-05-15T13:20:45Z [Term] id: GO:0140056 name: organelle localization by membrane tethering namespace: biological_process def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] subset: goslim_pombe is_a: GO:0022406 ! membrane docking is_a: GO:0051640 ! organelle localization created_by: pg creation_date: 2017-06-27T09:58:51Z [Term] id: GO:0140112 name: extracellular vesicle biogenesis namespace: biological_process def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] synonym: "extracellular vesicle assembly" EXACT [] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14256 xsd:anyURI created_by: pg creation_date: 2017-10-23T11:53:42Z [Term] id: GO:0140236 name: translation at presynapse namespace: biological_process def: "Translation that occurs at the presynapse." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/216 xsd:anyURI created_by: pg creation_date: 2018-07-13T13:00:33Z [Term] id: GO:0140237 name: translation at presynapse, modulating chemical synaptic transmission namespace: biological_process def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140236 ! translation at presynapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/216 xsd:anyURI created_by: pg creation_date: 2018-07-13T13:07:23Z [Term] id: GO:0140241 name: translation at synapse namespace: biological_process def: "Translation that occurs at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T09:23:12Z [Term] id: GO:0140242 name: translation at postsynapse namespace: biological_process def: "Translation that occurs at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T09:26:27Z [Term] id: GO:0140243 name: regulation of translation at synapse namespace: biological_process def: "Any process that regulates translation occurring at the synapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T09:38:26Z [Term] id: GO:0140244 name: regulation of translation at presynapse namespace: biological_process def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T09:38:33Z [Term] id: GO:0140245 name: regulation of translation at postsynapse namespace: biological_process def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T09:38:54Z [Term] id: GO:0140246 name: protein catabolic process at synapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input protein property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:12:51Z [Term] id: GO:0140247 name: protein catabolic process at presynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:23:49Z [Term] id: GO:0140249 name: protein catabolic process at postsynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:25:04Z [Term] id: GO:0140250 name: regulation protein catabolic process at synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input protein property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:34:56Z [Term] id: GO:0140251 name: regulation protein catabolic process at presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:35:39Z [Term] id: GO:0140252 name: regulation protein catabolic process at postsynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI created_by: pg creation_date: 2018-07-15T10:35:56Z [Term] id: GO:0140253 name: cell-cell fusion namespace: biological_process def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion] synonym: "cell cell fusion" EXACT [] synonym: "cell fusion" BROAD [] is_a: GO:0009987 ! cellular process relationship: has_part GO:0045026 ! plasma membrane fusion property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15939 xsd:anyURI created_by: pg creation_date: 2018-08-13T18:38:18Z [Term] id: GO:0140318 name: protein transporter activity namespace: molecular_function def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome" xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17073 xsd:anyURI created_by: pg creation_date: 2019-04-01T10:41:38Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: pg creation_date: 2019-05-22T11:20:45Z [Term] id: GO:0140353 name: lipid export from cell namespace: biological_process def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid created_by: pg creation_date: 2019-05-22T11:33:07Z [Term] id: GO:0140354 name: lipid import into cell namespace: biological_process def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure created_by: pg creation_date: 2019-05-22T11:38:15Z [Term] id: GO:0140513 name: nuclear protein-containing complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] subset: gocheck_do_not_annotate synonym: "nuclear complex" EXACT [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005634 ! nucleus relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0005634 ! nucleus created_by: pg creation_date: 2020-09-09T05:12:38Z [Term] id: GO:0140572 name: vacuole fission namespace: biological_process def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005773 ! vacuole relationship: results_in_fission_of GO:0005773 ! vacuole property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20639 xsd:anyURI created_by: pg creation_date: 2021-01-04T10:17:58Z [Term] id: GO:0140694 name: membraneless organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] synonym: "non-membrane-bounded organelle assembly" EXACT [] synonym: "non-membrane-bounded organelle formation" EXACT [] synonym: "non-membrane-enclosed organelle assembly" EXACT [] synonym: "non-membrane-enclosed organelle formation" EXACT [] is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle relationship: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21939 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29106 xsd:anyURI created_by: pg creation_date: 2021-08-09T15:30:06Z [Term] id: GO:0140734 name: ammonium excretion namespace: biological_process def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900] synonym: "ammonia excretion" RELATED [] is_a: GO:0007588 ! excretion intersection_of: GO:0007588 ! excretion intersection_of: RO:0004009 CHEBI:28938 ! has primary input ammonium relationship: RO:0004009 CHEBI:28938 ! has primary input ammonium property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22368 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: pg creation_date: 2021-11-24T17:55:51Z [Term] id: GO:0140961 name: cellular detoxification of metal ion namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion." [PMID:26729300, PMID:33046888, PMID:34442707] synonym: "cellular detoxification of metal cation" EXACT [] is_a: GO:0061687 ! detoxification of inorganic compound is_a: GO:1990748 ! cellular detoxification intersection_of: GO:1990748 ! cellular detoxification intersection_of: RO:0004009 CHEBI:25213 ! has primary input metal cation relationship: RO:0004009 CHEBI:25213 ! has primary input metal cation created_by: pg creation_date: 2022-12-07T15:35:18Z [Term] id: GO:0140962 name: multicellular organismal-level chemical homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators] synonym: "multicellular organism level chemical homeostasis" EXACT [] synonym: "organismal level chemical homeostasis" EXACT [] is_a: GO:0048871 ! multicellular organismal-level homeostasis is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048871 ! multicellular organismal-level homeostasis intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of chemical entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/24554 xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: pg creation_date: 2022-12-12T09:11:06Z [Term] id: GO:0141187 name: nucleic acid biosynthetic process namespace: biological_process def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33696 ! has primary output nucleic acid relationship: RO:0004008 CHEBI:33696 ! has primary output nucleic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27408 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27633 xsd:anyURI created_by: pg creation_date: 2024-03-25T07:33:40Z [Term] id: GO:0141188 name: nucleic acid catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27408 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27633 xsd:anyURI created_by: pg creation_date: 2024-03-25T07:35:06Z [Term] id: GO:0150052 name: regulation of postsynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854] subset: goslim_synapse is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099068 ! regulates postsynapse assembly relationship: RO:0002211 GO:0099068 ! regulates postsynapse assembly created_by: bc creation_date: 2018-05-08T16:38:55Z [Term] id: GO:0150063 name: visual system development namespace: biological_process def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727] synonym: "optic pathway development" RELATED [] synonym: "visual pathway development" RELATED [] is_a: GO:0048880 ! sensory system development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: bc creation_date: 2018-07-23T10:31:58Z [Term] id: GO:0150098 name: glial cell-neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] synonym: "glia-neuron signaling" EXACT [] synonym: "glia-neuron signalling" EXACT [] synonym: "glia-neurone signaling" EXACT [] synonym: "glia-neurone signalling" EXACT [] synonym: "glial cell- neuron signalling" EXACT [] synonym: "glial cell-neurone signalling" EXACT [] synonym: "glial cell-neurone singaling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000125 ! has start location glial cell intersection_of: RO:0002232 CL:0000540 ! has end location neuron relationship: RO:0002231 CL:0000125 ! has start location glial cell relationship: RO:0002232 CL:0000540 ! has end location neuron created_by: bc creation_date: 2018-12-17T12:28:09Z [Term] id: GO:0150099 name: neuron-glial cell signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] synonym: "neuron-glia signaling" EXACT [] synonym: "neuron-glia signalling" EXACT [] synonym: "neuron-glial cell signalling" EXACT [] synonym: "neurone-glia signaling" EXACT [] synonym: "neurone-glia signalling" EXACT [] synonym: "neurone-glial cell signaling" EXACT [] synonym: "neurone-glial cell signalling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000540 ! has start location neuron intersection_of: RO:0002232 CL:0000125 ! has end location glial cell relationship: RO:0002231 CL:0000540 ! has start location neuron relationship: RO:0002232 CL:0000125 ! has end location glial cell created_by: bc creation_date: 2018-12-17T12:30:12Z [Term] id: GO:0150105 name: protein localization to cell-cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005911 ! has target end location cell-cell junction relationship: RO:0002339 GO:0005911 ! has target end location cell-cell junction created_by: bc creation_date: 2019-06-11T11:00:18Z [Term] id: GO:0150106 name: regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction relationship: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction created_by: bc creation_date: 2019-06-11T11:17:15Z [Term] id: GO:0150107 name: positive regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction relationship: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction created_by: bc creation_date: 2019-06-11T11:23:58Z [Term] id: GO:0150111 name: regulation of transepithelial transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070633 ! regulates transepithelial transport relationship: RO:0002211 GO:0070633 ! regulates transepithelial transport created_by: bc creation_date: 2019-09-15T07:16:49Z [Term] id: GO:0150119 name: negative regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc] synonym: "negative regulation of protein localisation to cell-cell junction" EXACT [] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction relationship: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction created_by: bc creation_date: 2019-11-21T13:53:34Z [Term] id: GO:0150146 name: cell junction disassembly namespace: biological_process def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0030054 ! results in disassembly of cell junction relationship: RO:0002590 GO:0030054 ! results in disassembly of cell junction created_by: bc creation_date: 2019-12-08T11:12:13Z [Term] id: GO:0150147 name: cell-cell junction disassembly namespace: biological_process def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0045216 ! cell-cell junction organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction relationship: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction created_by: bc creation_date: 2019-12-08T11:16:14Z [Term] id: GO:0160038 name: somatic sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790] synonym: "somatosensory system development" EXACT [] is_a: GO:0048880 ! sensory system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003942 ! results in development of somatosensory system relationship: RO:0002296 UBERON:0003942 ! results in development of somatosensory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: rynl creation_date: 2022-07-07T16:49:26Z [Term] id: GO:0160043 name: catecholamine secretion, neurotransmission namespace: biological_process def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input catecholamine property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23804 xsd:anyURI created_by: rynl creation_date: 2022-08-17T00:36:44Z [Term] id: GO:0160093 name: chordate pharynx development namespace: biological_process def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903] is_a: GO:0060465 ! pharynx development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18285 xsd:anyURI created_by: rynl creation_date: 2023-08-29T21:05:28Z [Term] id: GO:0170055 name: lipid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators] subset: gocheck_do_not_annotate is_a: GO:0005319 ! lipid transporter activity is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27252 xsd:anyURI created_by: ew creation_date: 2024-03-15T18:47:58Z [Term] id: GO:1900076 name: regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032869 ! regulates cellular response to insulin stimulus relationship: RO:0002211 GO:0032869 ! regulates cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:22:22Z [Term] id: GO:1900077 name: negative regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032869 ! negatively regulates cellular response to insulin stimulus relationship: RO:0002212 GO:0032869 ! negatively regulates cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:23:15Z [Term] id: GO:1900078 name: positive regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus relationship: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:24:30Z [Term] id: GO:1900115 name: extracellular regulation of signal transduction namespace: biological_process def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0009966 ! regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region created_by: bf creation_date: 2012-02-22T10:21:48Z [Term] id: GO:1900116 name: extracellular negative regulation of signal transduction namespace: biological_process def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900115 ! extracellular regulation of signal transduction intersection_of: GO:0009968 ! negative regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region created_by: bf creation_date: 2012-02-22T10:27:56Z [Term] id: GO:1900117 name: regulation of execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis relationship: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:20Z [Term] id: GO:1900118 name: negative regulation of execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis relationship: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-02-22T11:26:24Z [Term] id: GO:1900119 name: positive regulation of execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis relationship: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-02-22T11:26:27Z [Term] id: GO:1900125 name: regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process relationship: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:21Z [Term] id: GO:1900126 name: negative regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process relationship: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:29Z [Term] id: GO:1900127 name: positive regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process relationship: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:33Z [Term] id: GO:1900180 name: regulation of protein localization to nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034504 ! regulates protein localization to nucleus relationship: RO:0002211 GO:0034504 ! regulates protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:44Z [Term] id: GO:1900181 name: negative regulation of protein localization to nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus relationship: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:48Z [Term] id: GO:1900182 name: positive regulation of protein localization to nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus relationship: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:52Z [Term] id: GO:1900193 name: regulation of oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] is_a: GO:1903429 ! regulation of cell maturation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001556 ! regulates oocyte maturation relationship: RO:0002211 GO:0001556 ! regulates oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:18Z [Term] id: GO:1900194 name: negative regulation of oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation relationship: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:27Z [Term] id: GO:1900195 name: positive regulation of oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001556 ! positively regulates oocyte maturation relationship: RO:0002213 GO:0001556 ! positively regulates oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:35Z [Term] id: GO:1900376 name: regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process relationship: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:23Z [Term] id: GO:1900377 name: negative regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044550 ! negatively regulates secondary metabolite biosynthetic process relationship: RO:0002212 GO:0044550 ! negatively regulates secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:32Z [Term] id: GO:1900378 name: positive regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044550 ! positively regulates secondary metabolite biosynthetic process relationship: RO:0002213 GO:0044550 ! positively regulates secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:41Z [Term] id: GO:1900619 name: acetate ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie] synonym: "acetate ester metabolism" EXACT [GOC:TermGenie] synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622] synonym: "acetyl ester metabolism" EXACT [CHEBI:47622] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:47622 ! has primary input or output acetate ester relationship: RO:0004007 CHEBI:47622 ! has primary input or output acetate ester created_by: bf creation_date: 2012-05-16T12:29:51Z [Term] id: GO:1900620 name: acetate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596] synonym: "acetate ester anabolism" EXACT [GOC:TermGenie] synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "acetate ester formation" EXACT [GOC:TermGenie] synonym: "acetate ester synthesis" EXACT [GOC:TermGenie] synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622] synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622] is_a: GO:0009058 ! biosynthetic process is_a: GO:1900619 ! acetate ester metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:47622 ! has primary output acetate ester relationship: RO:0004008 CHEBI:47622 ! has primary output acetate ester created_by: bf creation_date: 2012-05-16T12:30:12Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] subset: goslim_agr subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative relationship: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative created_by: bf creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901136 name: carbohydrate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative created_by: bf creation_date: 2012-07-12T04:05:31Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative relationship: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative created_by: bf creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901142 name: insulin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie] synonym: "insulin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000009054 ! has primary input or output insulin gene translation product relationship: RO:0004007 PR:000009054 ! has primary input or output insulin gene translation product property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:4751 created_by: pm creation_date: 2012-07-13T12:32:40Z [Term] id: GO:1901143 name: insulin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie] synonym: "insulin breakdown" EXACT [GOC:TermGenie] synonym: "insulin catabolism" EXACT [GOC:TermGenie] synonym: "insulin degradation" EXACT [GOC:TermGenie] is_a: GO:0030163 ! protein catabolic process is_a: GO:1901142 ! insulin metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 PR:000009054 ! has primary input insulin gene translation product relationship: RO:0004009 PR:000009054 ! has primary input insulin gene translation product property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:4751 created_by: pm creation_date: 2012-07-13T12:33:03Z [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization namespace: biological_process def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] synonym: "extracellular matrix protein production" RELATED [GOC:pg] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: part_of GO:0030198 ! extracellular matrix organization relationship: part_of GO:0030198 ! extracellular matrix organization created_by: bf creation_date: 2012-07-16T03:29:30Z [Term] id: GO:1901160 name: primary amino compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie] synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:50994 ! has primary input or output primary amino compound relationship: RO:0004007 CHEBI:50994 ! has primary input or output primary amino compound created_by: bf creation_date: 2012-07-18T04:44:39Z [Term] id: GO:1901161 name: primary amino compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901160 ! primary amino compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:50994 ! has primary input primary amino compound relationship: RO:0004009 CHEBI:50994 ! has primary input primary amino compound created_by: bf creation_date: 2012-07-18T04:45:06Z [Term] id: GO:1901162 name: primary amino compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] synonym: "primary amino compound formation" EXACT [GOC:TermGenie] synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901160 ! primary amino compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:50994 ! has primary output primary amino compound relationship: RO:0004008 CHEBI:50994 ! has primary output primary amino compound created_by: bf creation_date: 2012-07-18T04:45:14Z [Term] id: GO:1901190 name: regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex relationship: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:26:58Z [Term] id: GO:1901191 name: negative regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex relationship: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:21Z [Term] id: GO:1901192 name: positive regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex relationship: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:29Z [Term] id: GO:1901201 name: regulation of extracellular matrix assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly relationship: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:00Z [Term] id: GO:1901202 name: negative regulation of extracellular matrix assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie] is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly relationship: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:24Z [Term] id: GO:1901203 name: positive regulation of extracellular matrix assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie] synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly relationship: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:32Z [Term] id: GO:1901210 name: regulation of cardiac chamber formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003207 ! regulates cardiac chamber formation relationship: RO:0002211 GO:0003207 ! regulates cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:18:35Z [Term] id: GO:1901211 name: negative regulation of cardiac chamber formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation relationship: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:18:57Z [Term] id: GO:1901212 name: positive regulation of cardiac chamber formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation relationship: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:19:05Z [Term] id: GO:1901219 name: regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis relationship: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:11Z [Term] id: GO:1901220 name: negative regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis relationship: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:34Z [Term] id: GO:1901221 name: positive regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis relationship: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:42Z [Term] id: GO:1901264 name: carbohydrate derivative transport namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative created_by: bf creation_date: 2012-08-16T14:51:22Z [Term] id: GO:1901342 name: regulation of vasculature development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001944 ! regulates vasculature development relationship: RO:0002211 GO:0001944 ! regulates vasculature development created_by: bf creation_date: 2012-09-06T09:16:15Z [Term] id: GO:1901343 name: negative regulation of vasculature development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001944 ! negatively regulates vasculature development relationship: RO:0002212 GO:0001944 ! negatively regulates vasculature development created_by: bf creation_date: 2012-09-06T09:17:24Z [Term] id: GO:1901374 name: acetate ester transport namespace: biological_process def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:47622 ! has primary input acetate ester relationship: RO:0004009 CHEBI:47622 ! has primary input acetate ester created_by: bf creation_date: 2012-09-28T10:42:13Z [Term] id: GO:1901375 name: acetate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:47622 ! has primary input acetate ester relationship: part_of GO:1901374 ! acetate ester transport relationship: RO:0004009 CHEBI:47622 ! has primary input acetate ester created_by: bf creation_date: 2012-09-28T10:47:08Z [Term] id: GO:1901401 name: regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033013 ! regulates tetrapyrrole metabolic process relationship: RO:0002211 GO:0033013 ! regulates tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:34:03Z [Term] id: GO:1901402 name: negative regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033013 ! negatively regulates tetrapyrrole metabolic process relationship: RO:0002212 GO:0033013 ! negatively regulates tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:11Z [Term] id: GO:1901403 name: positive regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033013 ! positively regulates tetrapyrrole metabolic process relationship: RO:0002213 GO:0033013 ! positively regulates tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:29Z [Term] id: GO:1901404 name: regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033015 ! regulates tetrapyrrole catabolic process relationship: RO:0002211 GO:0033015 ! regulates tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:38:12Z [Term] id: GO:1901405 name: negative regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033015 ! negatively regulates tetrapyrrole catabolic process relationship: RO:0002212 GO:0033015 ! negatively regulates tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:39:22Z [Term] id: GO:1901406 name: positive regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033015 ! positively regulates tetrapyrrole catabolic process relationship: RO:0002213 GO:0033015 ! positively regulates tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:39:40Z [Term] id: GO:1901457 name: regulation of response to acetate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010034 ! regulates response to acetate relationship: RO:0002211 GO:0010034 ! regulates response to acetate created_by: tt creation_date: 2012-10-02T14:25:06Z [Term] id: GO:1901458 name: negative regulation of response to acetate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie] synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901457 ! regulation of response to acetate intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010034 ! negatively regulates response to acetate relationship: RO:0002212 GO:0010034 ! negatively regulates response to acetate created_by: tt creation_date: 2012-10-02T14:26:15Z [Term] id: GO:1901459 name: positive regulation of response to acetate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to acetate" NARROW [GOC:TermGenie] synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901457 ! regulation of response to acetate intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010034 ! positively regulates response to acetate relationship: RO:0002213 GO:0010034 ! positively regulates response to acetate created_by: tt creation_date: 2012-10-02T14:26:34Z [Term] id: GO:1901463 name: regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033014 ! regulates tetrapyrrole biosynthetic process relationship: RO:0002211 GO:0033014 ! regulates tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:34:14Z [Term] id: GO:1901464 name: negative regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033014 ! negatively regulates tetrapyrrole biosynthetic process relationship: RO:0002212 GO:0033014 ! negatively regulates tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:35:26Z [Term] id: GO:1901465 name: positive regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033014 ! positively regulates tetrapyrrole biosynthetic process relationship: RO:0002213 GO:0033014 ! positively regulates tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:35:43Z [Term] id: GO:1901505 name: carbohydrate derivative transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "carbohydrate derivative transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: part_of GO:1901264 {source="GO_REF:0000090"} ! carbohydrate derivative transport relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative created_by: pr creation_date: 2012-10-17T10:31:22Z [Term] id: GO:1901509 name: regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis relationship: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis created_by: dph creation_date: 2012-10-17T14:30:40Z [Term] id: GO:1901532 name: regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation relationship: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:01Z [Term] id: GO:1901533 name: negative regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation relationship: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:06Z [Term] id: GO:1901534 name: positive regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT [] synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation relationship: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:14Z [Term] id: GO:1901550 name: regulation of endothelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] is_a: GO:0045601 ! regulation of endothelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001885 ! regulates endothelial cell development relationship: RO:0002211 GO:0001885 ! regulates endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:50Z [Term] id: GO:1901551 name: negative regulation of endothelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development relationship: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:54Z [Term] id: GO:1901552 name: positive regulation of endothelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001885 ! positively regulates endothelial cell development relationship: RO:0002213 GO:0001885 ! positively regulates endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:58Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion relationship: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion relationship: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion relationship: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901608 name: regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule relationship: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:44Z [Term] id: GO:1901609 name: negative regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule relationship: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:48Z [Term] id: GO:1901610 name: positive regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule relationship: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:53Z [Term] id: GO:1901652 name: response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion created_by: pr creation_date: 2012-11-20T09:45:15Z [Term] id: GO:1901653 name: cellular response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901652 ! response to peptide intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion created_by: pr creation_date: 2012-11-20T09:45:19Z [Term] id: GO:1901654 name: response to ketone namespace: biological_process alt_id: GO:1990369 def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] synonym: "process resulting in tolerance to ketone" NARROW [] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17087 ! has primary input ketone relationship: RO:0004009 CHEBI:17087 ! has primary input ketone created_by: pr creation_date: 2012-11-20T10:55:47Z [Term] id: GO:1901655 name: cellular response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:1901654 ! response to ketone is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17087 ! has primary input ketone created_by: pr creation_date: 2012-11-20T10:55:51Z [Term] id: GO:1901682 name: sulfur compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "sulfur molecular entity transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity relationship: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity created_by: pr creation_date: 2012-11-26T20:45:29Z [Term] id: GO:1901692 name: regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process relationship: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-12-12T10:28:35Z [Term] id: GO:1901693 name: negative regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process relationship: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-12-12T10:28:40Z [Term] id: GO:1901694 name: positive regulation of compound eye retinal cell apoptotic process namespace: biological_process alt_id: GO:0046675 def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] synonym: "induction of compound eye retinal cell programmed cell death" RELATED [] synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process relationship: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-12-12T10:28:45Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27194 xsd:anyURI created_by: pr creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27194 xsd:anyURI created_by: pr creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity relationship: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/27194 xsd:anyURI created_by: pr creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity created_by: pr creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901702 name: salt transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24866 ! has primary input salt relationship: RO:0004009 CHEBI:24866 ! has primary input salt created_by: pr creation_date: 2012-12-13T15:14:47Z [Term] id: GO:1901706 name: mesenchymal cell differentiation involved in bone development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0060348 ! bone development relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060348 ! bone development created_by: hjd creation_date: 2012-12-14T16:04:16Z [Term] id: GO:1901861 name: regulation of muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060537 ! regulates muscle tissue development relationship: RO:0002211 GO:0060537 ! regulates muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:47Z [Term] id: GO:1901862 name: negative regulation of muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development relationship: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:52Z [Term] id: GO:1901863 name: positive regulation of muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060537 ! positively regulates muscle tissue development relationship: RO:0002213 GO:0060537 ! positively regulates muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:57Z [Term] id: GO:1901879 name: regulation of protein depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051261 ! regulates protein depolymerization relationship: RO:0002211 GO:0051261 ! regulates protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:23Z [Term] id: GO:1901880 name: negative regulation of protein depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization relationship: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:28Z [Term] id: GO:1901881 name: positive regulation of protein depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie] synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051261 ! positively regulates protein depolymerization relationship: RO:0002213 GO:0051261 ! positively regulates protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:32Z [Term] id: GO:1901888 name: regulation of cell junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034329 ! regulates cell junction assembly relationship: RO:0002211 GO:0034329 ! regulates cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:32Z [Term] id: GO:1901889 name: negative regulation of cell junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly relationship: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:41Z [Term] id: GO:1901890 name: positive regulation of cell junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034329 ! positively regulates cell junction assembly relationship: RO:0002213 GO:0034329 ! positively regulates cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:46Z [Term] id: GO:1901963 name: regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2013-02-20T20:30:26Z [Term] id: GO:1901964 name: positive regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2013-02-20T20:30:31Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060271 ! regulates cilium assembly relationship: RO:0002211 GO:0060271 ! regulates cilium assembly property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060271 ! negatively regulates cilium assembly relationship: RO:0002212 GO:0060271 ! negatively regulates cilium assembly property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902033 name: regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation relationship: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: ss creation_date: 2013-04-02T05:13:19Z [Term] id: GO:1902034 name: negative regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:1903707 ! negative regulation of hemopoiesis is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation relationship: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: ss creation_date: 2013-04-02T05:13:24Z [Term] id: GO:1902035 name: positive regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation relationship: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: ss creation_date: 2013-04-02T05:13:31Z [Term] id: GO:1902036 name: regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-8939236 "RUNX1 regulates transcription of genes involved in differentiation of HSCs" is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation relationship: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:09Z [Term] id: GO:1902037 name: negative regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation relationship: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:14Z [Term] id: GO:1902038 name: positive regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation relationship: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:19Z [Term] id: GO:1902074 name: response to salt namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] synonym: "response to salinity" NARROW [GOC:mls] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24866 ! has primary input salt relationship: RO:0004009 CHEBI:24866 ! has primary input salt created_by: mls creation_date: 2013-04-22T15:41:57Z [Term] id: GO:1902075 name: cellular response to salt namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] synonym: "cellular response to salinity" NARROW [GOC:mls] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1902074 ! response to salt intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:24866 ! has primary input salt created_by: mls creation_date: 2013-04-22T15:42:02Z [Term] id: GO:1902105 name: regulation of leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002521 ! regulates leukocyte differentiation relationship: RO:0002211 GO:0002521 ! regulates leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:42Z [Term] id: GO:1902106 name: negative regulation of leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation relationship: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:47Z [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation relationship: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:52Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070925 ! regulates organelle assembly relationship: RO:0002211 GO:0070925 ! regulates organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070925 ! negatively regulates organelle assembly relationship: RO:0002212 GO:0070925 ! negatively regulates organelle assembly created_by: pr creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070925 ! positively regulates organelle assembly relationship: RO:0002213 GO:0070925 ! positively regulates organelle assembly created_by: pr creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902217 name: erythrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033028 ! myeloid cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000232 ! occurs in erythrocyte relationship: BFO:0000066 CL:0000232 ! occurs in erythrocyte property_value: RO:0002161 NCBITaxon:4751 created_by: rl creation_date: 2013-06-13T10:02:29Z [Term] id: GO:1902250 name: regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process relationship: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: rl creation_date: 2013-06-20T19:30:53Z [Term] id: GO:1902251 name: negative regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process relationship: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 created_by: rl creation_date: 2013-06-20T19:30:59Z [Term] id: GO:1902252 name: positive regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process relationship: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 created_by: rl creation_date: 2013-06-20T19:31:04Z [Term] id: GO:1902256 name: regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: dph creation_date: 2013-06-24T19:12:24Z [Term] id: GO:1902257 name: negative regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: dph creation_date: 2013-06-24T19:12:30Z [Term] id: GO:1902258 name: positive regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: dph creation_date: 2013-06-24T19:12:42Z [Term] id: GO:1902262 name: apoptotic process involved in blood vessel morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2013-06-25T16:16:00Z [Term] id: GO:1902275 name: regulation of chromatin organization namespace: biological_process alt_id: GO:0001672 alt_id: GO:1903308 def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] synonym: "regulation of chromatin assembly or disassembly" RELATED [] synonym: "regulation of chromatin assembly/disassembly" RELATED [] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006325 ! regulates chromatin organization relationship: RO:0002211 GO:0006325 ! regulates chromatin organization created_by: bf creation_date: 2013-07-01T13:21:52Z [Term] id: GO:1902305 name: regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035725 ! regulates sodium ion transmembrane transport relationship: RO:0002211 GO:0035725 ! regulates sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:33:53Z [Term] id: GO:1902306 name: negative regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0010766 ! negative regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035725 ! negatively regulates sodium ion transmembrane transport relationship: RO:0002212 GO:0035725 ! negatively regulates sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:34:01Z [Term] id: GO:1902307 name: positive regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0010765 ! positive regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035725 ! positively regulates sodium ion transmembrane transport relationship: RO:0002213 GO:0035725 ! positively regulates sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:34:18Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis relationship: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: sart creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis relationship: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: sart creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis relationship: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 created_by: sart creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902340 name: negative regulation of chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation relationship: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation created_by: dgf creation_date: 2013-07-29T20:54:14Z [Term] id: GO:1902358 name: sulfate transmembrane transport namespace: biological_process def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] synonym: "sulphate transport" EXACT [] is_a: GO:0072348 ! sulfur compound transport is_a: GO:0098661 ! inorganic anion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:16189 ! has primary input sulfate relationship: RO:0004009 CHEBI:16189 ! has primary input sulfate property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28653 xsd:anyURI created_by: dph creation_date: 2013-08-14T14:46:04Z [Term] id: GO:1902369 name: negative regulation of RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process relationship: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process created_by: bf creation_date: 2013-08-22T14:59:39Z [Term] id: GO:1902414 name: protein localization to cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie] synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie] synonym: "protein localization in cell junction" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0030054 ! has target end location cell junction relationship: RO:0002339 GO:0030054 ! has target end location cell junction created_by: tb creation_date: 2013-09-13T16:55:57Z [Term] id: GO:1902463 name: protein localization to cell leading edge namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326] synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0031252 ! has target end location cell leading edge relationship: RO:0002339 GO:0031252 ! has target end location cell leading edge created_by: jl creation_date: 2013-10-22T12:36:07Z [Term] id: GO:1902473 name: regulation of protein localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035418 ! regulates protein localization to synapse relationship: RO:0002211 GO:0035418 ! regulates protein localization to synapse created_by: kmv creation_date: 2013-10-25T15:09:09Z [Term] id: GO:1902474 name: positive regulation of protein localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse relationship: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse created_by: kmv creation_date: 2013-10-25T15:09:18Z [Term] id: GO:1902488 name: cholangiocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800] synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:1000488 ! occurs in cholangiocyte relationship: BFO:0000066 CL:1000488 ! occurs in cholangiocyte property_value: RO:0002161 NCBITaxon:4751 created_by: cls creation_date: 2013-11-12T15:30:08Z [Term] id: GO:1902489 name: hepatoblast apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967] synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0005026 ! occurs in hepatoblast relationship: BFO:0000066 CL:0005026 ! occurs in hepatoblast property_value: RO:0002161 NCBITaxon:4896 created_by: cls creation_date: 2013-11-12T17:02:52Z [Term] id: GO:1902495 name: transmembrane transporter complex namespace: cellular_component def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990351 ! transporter complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: capable_of GO:0022857 ! transmembrane transporter activity relationship: capable_of GO:0022857 ! transmembrane transporter activity created_by: bhm creation_date: 2013-11-13T16:23:04Z [Term] id: GO:1902513 name: regulation of organelle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087] synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule relationship: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule created_by: dph creation_date: 2013-11-15T20:15:17Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010627 def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035556 ! regulates intracellular signal transduction relationship: RO:0002211 GO:0035556 ! regulates intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010741 def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction relationship: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010740 def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction relationship: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902570 name: protein localization to nucleolus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus relationship: RO:0002339 GO:0005730 ! has target end location nucleolus created_by: mah creation_date: 2013-12-10T16:25:28Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process relationship: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process relationship: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902692 name: regulation of neuroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007405 ! regulates neuroblast proliferation relationship: RO:0002211 GO:0007405 ! regulates neuroblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: rl creation_date: 2014-02-18T10:03:31Z [Term] id: GO:1902738 name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis relationship: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis created_by: mr creation_date: 2014-02-26T15:36:15Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048856 ! anatomical structure development relationship: part_of GO:0048856 ! anatomical structure development property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902761 name: positive regulation of chondrocyte development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0032332 ! positive regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002063 ! positively regulates chondrocyte development relationship: RO:0002213 GO:0002063 ! positively regulates chondrocyte development created_by: mr creation_date: 2014-03-07T17:45:55Z [Term] id: GO:1902809 name: regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation relationship: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:26Z [Term] id: GO:1902810 name: negative regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation relationship: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:32Z [Term] id: GO:1902811 name: positive regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation relationship: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:38Z [Term] id: GO:1902816 name: regulation of protein localization to microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035372 ! regulates protein localization to microtubule relationship: RO:0002211 GO:0035372 ! regulates protein localization to microtubule created_by: tb creation_date: 2014-03-27T22:07:12Z [Term] id: GO:1902817 name: negative regulation of protein localization to microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:1902816 ! regulation of protein localization to microtubule is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule relationship: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule created_by: tb creation_date: 2014-03-27T22:07:18Z [Term] id: GO:1902838 name: regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie] synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie] synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule relationship: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:23Z [Term] id: GO:1902839 name: negative regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule relationship: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:29Z [Term] id: GO:1902840 name: positive regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule relationship: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:35Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: vw creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902863 name: regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development relationship: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:00Z [Term] id: GO:1902864 name: negative regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie] synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development relationship: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:06Z [Term] id: GO:1902865 name: positive regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie] synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development relationship: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:12Z [Term] id: GO:1902866 name: regulation of retina development in camera-type eye namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye relationship: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:17Z [Term] id: GO:1902867 name: negative regulation of retina development in camera-type eye namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down regulation of retinal development" RELATED [GOC:TermGenie] synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "downregulation of retinal development" RELATED [GOC:TermGenie] synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "inhibition of retinal development" RELATED [GOC:TermGenie] synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye relationship: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:23Z [Term] id: GO:1902868 name: positive regulation of retina development in camera-type eye namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "activation of retinal development" RELATED [GOC:TermGenie] synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "upregulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye relationship: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:29Z [Term] id: GO:1902903 name: regulation of supramolecular fiber organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization relationship: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:36Z [Term] id: GO:1902904 name: negative regulation of supramolecular fiber organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization relationship: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:42Z [Term] id: GO:1902905 name: positive regulation of supramolecular fiber organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of fibril organization" NARROW [GOC:TermGenie] synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization relationship: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:48Z [Term] id: GO:1902913 name: positive regulation of neuroepithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506] synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation relationship: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation created_by: mr creation_date: 2014-04-18T21:06:42Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0043226 ! results in disassembly of organelle relationship: RO:0002590 GO:0043226 ! results in disassembly of organelle created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903010 name: regulation of bone development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060348 ! regulates bone development relationship: RO:0002211 GO:0060348 ! regulates bone development created_by: mr creation_date: 2014-05-13T22:41:53Z [Term] id: GO:1903011 name: negative regulation of bone development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "down regulation of bone development" EXACT [GOC:TermGenie] synonym: "down-regulation of bone development" EXACT [GOC:TermGenie] synonym: "downregulation of bone development" EXACT [GOC:TermGenie] synonym: "inhibition of bone development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060348 ! negatively regulates bone development relationship: RO:0002212 GO:0060348 ! negatively regulates bone development created_by: mr creation_date: 2014-05-13T22:42:00Z [Term] id: GO:1903012 name: positive regulation of bone development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "activation of bone development" NARROW [GOC:TermGenie] synonym: "up regulation of bone development" EXACT [GOC:TermGenie] synonym: "up-regulation of bone development" EXACT [GOC:TermGenie] synonym: "upregulation of bone development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060348 ! positively regulates bone development relationship: RO:0002213 GO:0060348 ! positively regulates bone development created_by: mr creation_date: 2014-05-13T22:42:06Z [Term] id: GO:1903018 name: regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process relationship: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:19Z [Term] id: GO:1903019 name: negative regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process relationship: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:25Z [Term] id: GO:1903020 name: positive regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process relationship: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:31Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903053 name: regulation of extracellular matrix organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030198 ! regulates extracellular matrix organization relationship: RO:0002211 GO:0030198 ! regulates extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:41Z [Term] id: GO:1903054 name: negative regulation of extracellular matrix organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization relationship: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:47Z [Term] id: GO:1903055 name: positive regulation of extracellular matrix organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization relationship: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:53Z [Term] id: GO:1903076 name: regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090003 alt_id: GO:1905963 def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to plasma membrane" RELATED [] synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane relationship: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane created_by: tb creation_date: 2009-07-10T10:32:44Z [Term] id: GO:1903077 name: negative regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090005 alt_id: GO:1905964 def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane relationship: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane created_by: tb creation_date: 2014-05-29T17:10:16Z [Term] id: GO:1903078 name: positive regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090004 alt_id: GO:1905965 def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane relationship: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane created_by: tb creation_date: 2009-07-10T10:34:17Z [Term] id: GO:1903115 name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030048 ! regulates actin filament-based movement relationship: RO:0002211 GO:0030048 ! regulates actin filament-based movement created_by: al creation_date: 2014-06-12T16:55:57Z [Term] id: GO:1903116 name: positive regulation of actin filament-based movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement relationship: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement created_by: al creation_date: 2014-06-12T16:56:04Z [Term] id: GO:1903119 name: protein localization to actin cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton relationship: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton created_by: mah creation_date: 2014-06-16T11:27:09Z [Term] id: GO:1903120 name: protein localization to actin filament bundle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization to actin cable" RELATED [GOC:mah] is_a: GO:1903119 ! protein localization to actin cytoskeleton intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0032432 ! has target end location actin filament bundle relationship: RO:0002339 GO:0032432 ! has target end location actin filament bundle created_by: mah creation_date: 2014-06-16T11:27:16Z [Term] id: GO:1903224 name: regulation of endodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation relationship: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:35Z [Term] id: GO:1903225 name: negative regulation of endodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation relationship: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:41Z [Term] id: GO:1903226 name: positive regulation of endodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation relationship: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:47Z [Term] id: GO:1903292 name: protein localization to Golgi membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] is_a: GO:0034067 ! protein localization to Golgi apparatus is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0000139 ! has target end location Golgi membrane relationship: RO:0002339 GO:0000139 ! has target end location Golgi membrane created_by: mah creation_date: 2014-08-12T14:22:31Z [Term] id: GO:1903335 name: regulation of vacuolar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007034 ! regulates vacuolar transport relationship: RO:0002211 GO:0007034 ! regulates vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:04Z [Term] id: GO:1903336 name: negative regulation of vacuolar transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport relationship: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:11Z [Term] id: GO:1903337 name: positive regulation of vacuolar transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007034 ! positively regulates vacuolar transport relationship: RO:0002213 GO:0007034 ! positively regulates vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:19Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006997 ! regulates nucleus organization relationship: RO:0002211 GO:0006997 ! regulates nucleus organization created_by: hjd creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903358 name: regulation of Golgi organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788] synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie] synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007030 ! regulates Golgi organization relationship: RO:0002211 GO:0007030 ! regulates Golgi organization created_by: als creation_date: 2014-08-21T10:22:22Z [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0060623 ! regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation relationship: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:13Z [Term] id: GO:1903380 name: positive regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903379 ! regulation of mitotic chromosome condensation is_a: GO:1905821 ! positive regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation relationship: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:29Z [Term] id: GO:1903412 name: response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:3098 ! has primary input bile acid relationship: RO:0004009 CHEBI:3098 ! has primary input bile acid created_by: rl creation_date: 2014-09-03T12:45:43Z [Term] id: GO:1903413 name: cellular response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903412 ! response to bile acid intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:3098 ! has primary input bile acid created_by: rl creation_date: 2014-09-03T12:45:51Z [Term] id: GO:1903429 name: regulation of cell maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048469 ! regulates cell maturation relationship: RO:0002211 GO:0048469 ! regulates cell maturation created_by: jl creation_date: 2014-09-15T13:31:23Z [Term] id: GO:1903430 name: negative regulation of cell maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048469 ! negatively regulates cell maturation relationship: RO:0002212 GO:0048469 ! negatively regulates cell maturation created_by: jl creation_date: 2014-09-15T13:31:32Z [Term] id: GO:1903431 name: positive regulation of cell maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "activation of cell maturation" NARROW [GOC:TermGenie] synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048469 ! positively regulates cell maturation relationship: RO:0002213 GO:0048469 ! positively regulates cell maturation created_by: jl creation_date: 2014-09-15T13:31:41Z [Term] id: GO:1903441 name: protein localization to ciliary membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0060170 ! has target end location ciliary membrane relationship: RO:0002339 GO:0060170 ! has target end location ciliary membrane property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: pr creation_date: 2014-09-16T15:15:39Z [Term] id: GO:1903522 name: regulation of blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008015 ! regulates blood circulation relationship: RO:0002211 GO:0008015 ! regulates blood circulation created_by: mr creation_date: 2014-10-06T18:38:56Z [Term] id: GO:1903523 name: negative regulation of blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008015 ! negatively regulates blood circulation relationship: RO:0002212 GO:0008015 ! negatively regulates blood circulation created_by: mr creation_date: 2014-10-06T18:39:05Z [Term] id: GO:1903524 name: positive regulation of blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "activation of blood circulation" NARROW [GOC:TermGenie] synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008015 ! positively regulates blood circulation relationship: RO:0002213 GO:0008015 ! positively regulates blood circulation created_by: mr creation_date: 2014-10-06T18:39:13Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032940 ! regulates secretion by cell relationship: RO:0002211 GO:0032940 ! regulates secretion by cell created_by: pm creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032940 ! negatively regulates secretion by cell relationship: RO:0002212 GO:0032940 ! negatively regulates secretion by cell created_by: pm creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032940 ! positively regulates secretion by cell relationship: RO:0002213 GO:0032940 ! positively regulates secretion by cell created_by: pm creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903537 name: meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "meiosis involved in oocyte maturation" BROAD [] is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1903046 ! meiotic cell cycle process intersection_of: part_of GO:0001556 ! oocyte maturation relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0001556 ! oocyte maturation created_by: pr creation_date: 2014-10-09T10:46:14Z [Term] id: GO:1903538 name: regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation created_by: pr creation_date: 2014-10-09T10:52:38Z [Term] id: GO:1903541 name: regulation of exosomal secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990182 ! regulates exosomal secretion relationship: RO:0002211 GO:1990182 ! regulates exosomal secretion created_by: pga creation_date: 2014-10-14T11:38:52Z [Term] id: GO:1903542 name: negative regulation of exosomal secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion relationship: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion created_by: pga creation_date: 2014-10-14T11:39:02Z [Term] id: GO:1903543 name: positive regulation of exosomal secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990182 ! positively regulates exosomal secretion relationship: RO:0002213 GO:1990182 ! positively regulates exosomal secretion created_by: pga creation_date: 2014-10-14T11:39:10Z [Term] id: GO:1903551 name: regulation of extracellular exosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly relationship: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:25Z [Term] id: GO:1903552 name: negative regulation of extracellular exosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly relationship: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:33Z [Term] id: GO:1903553 name: positive regulation of extracellular exosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly relationship: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:42Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005576 ! extracellular region created_by: jl creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061512 ! regulates protein localization to cilium relationship: RO:0002211 GO:0061512 ! regulates protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium relationship: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium relationship: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903567 name: regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane relationship: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:32:51Z [Term] id: GO:1903568 name: negative regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903565 ! negative regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane relationship: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:32:59Z [Term] id: GO:1903569 name: positive regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903566 ! positive regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane relationship: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:33:08Z [Term] id: GO:1903697 name: negative regulation of microvillus assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly relationship: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly created_by: als creation_date: 2014-12-03T11:45:08Z [Term] id: GO:1903698 name: positive regulation of microvillus assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030033 ! positively regulates microvillus assembly relationship: RO:0002213 GO:0030033 ! positively regulates microvillus assembly created_by: als creation_date: 2014-12-03T11:45:17Z [Term] id: GO:1903701 name: substantia propria of cornea development namespace: biological_process def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382] synonym: "corneal stroma development" EXACT [GOC:TermGenie] synonym: "stroma of cornea development" EXACT [GOC:TermGenie] synonym: "substantia propria development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea created_by: cls creation_date: 2014-12-03T13:12:09Z [Term] id: GO:1903702 name: esophagus development namespace: biological_process def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "esophageal development" EXACT [MGI:csmith] synonym: "gullet development" EXACT [GOC:TermGenie] synonym: "oesophagus development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001043 ! results in development of esophagus relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0001043 ! results in development of esophagus created_by: cls creation_date: 2014-12-03T14:41:30Z [Term] id: GO:1903706 name: regulation of hemopoiesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030097 ! regulates hemopoiesis relationship: RO:0002211 GO:0030097 ! regulates hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:13Z [Term] id: GO:1903707 name: negative regulation of hemopoiesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis relationship: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:21Z [Term] id: GO:1903708 name: positive regulation of hemopoiesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030097 ! positively regulates hemopoiesis relationship: RO:0002213 GO:0030097 ! positively regulates hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:30Z [Term] id: GO:1903729 name: regulation of plasma membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007009 ! regulates plasma membrane organization relationship: RO:0002211 GO:0007009 ! regulates plasma membrane organization created_by: al creation_date: 2014-12-10T18:59:44Z [Term] id: GO:1903778 name: protein localization to vacuolar membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005774 ! has target end location vacuolar membrane relationship: RO:0002339 GO:0005774 ! has target end location vacuolar membrane created_by: mah creation_date: 2015-01-07T13:15:54Z [Term] id: GO:1903779 name: regulation of cardiac conduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] xref: Reactome:R-HSA-5578768 "Physiological factors" xref: Reactome:R-HSA-5578775 "Ion homeostasis" is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061337 ! regulates cardiac conduction relationship: RO:0002211 GO:0061337 ! regulates cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:11Z [Term] id: GO:1903780 name: negative regulation of cardiac conduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction relationship: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:20Z [Term] id: GO:1903781 name: positive regulation of cardiac conduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061337 ! positively regulates cardiac conduction relationship: RO:0002213 GO:0061337 ! positively regulates cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:28Z [Term] id: GO:1903789 name: regulation of amino acid transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport relationship: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport created_by: al creation_date: 2015-01-08T17:42:18Z [Term] id: GO:1903795 name: regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098661 ! regulates inorganic anion transmembrane transport relationship: RO:0002211 GO:0098661 ! regulates inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:44:49Z [Term] id: GO:1903796 name: negative regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098661 ! negatively regulates inorganic anion transmembrane transport relationship: RO:0002212 GO:0098661 ! negatively regulates inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:44:59Z [Term] id: GO:1903797 name: positive regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098661 ! positively regulates inorganic anion transmembrane transport relationship: RO:0002213 GO:0098661 ! positively regulates inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:45:08Z [Term] id: GO:1903825 name: organic acid transmembrane transport namespace: biological_process def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0015849 ! organic acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid created_by: vw creation_date: 2015-01-20T10:20:58Z [Term] id: GO:1903828 name: negative regulation of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein localization" EXACT [] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008104 ! negatively regulates protein localization relationship: RO:0002212 GO:0008104 ! negatively regulates protein localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22021 xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein localization" EXACT [] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008104 ! positively regulates protein localization relationship: RO:0002213 GO:0008104 ! positively regulates protein localization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22021 xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1903831 name: signal transduction involved in cellular response to ammonium ion namespace: biological_process def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994] synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0071242 ! cellular response to ammonium ion relationship: part_of GO:0071242 ! cellular response to ammonium ion created_by: al creation_date: 2015-01-21T17:52:09Z [Term] id: GO:1903847 name: regulation of aorta morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035909 ! regulates aorta morphogenesis relationship: RO:0002211 GO:0035909 ! regulates aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:00:51Z [Term] id: GO:1903848 name: negative regulation of aorta morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905652 ! negative regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis relationship: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:01:01Z [Term] id: GO:1903849 name: positive regulation of aorta morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905653 ! positive regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis relationship: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:01:09Z [Term] id: GO:1903867 name: extraembryonic membrane development namespace: biological_process def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane created_by: cjm creation_date: 2015-02-05T00:42:16Z [Term] id: GO:1903941 name: negative regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system created_by: sl creation_date: 2015-02-17T20:26:24Z [Term] id: GO:1903942 name: positive regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie] synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system created_by: sl creation_date: 2015-02-17T20:26:35Z [Term] id: GO:1903943 name: regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097284 ! regulates hepatocyte apoptotic process relationship: RO:0002211 GO:0097284 ! regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-02-19T12:54:40Z [Term] id: GO:1903944 name: negative regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097284 ! negatively regulates hepatocyte apoptotic process relationship: RO:0002212 GO:0097284 ! negatively regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-02-19T12:54:50Z [Term] id: GO:1903945 name: positive regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097284 ! positively regulates hepatocyte apoptotic process relationship: RO:0002213 GO:0097284 ! positively regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-02-19T12:54:59Z [Term] id: GO:1903950 name: negative regulation of AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential relationship: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential created_by: nc creation_date: 2015-02-20T14:59:41Z [Term] id: GO:1903951 name: positive regulation of AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential relationship: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential created_by: nc creation_date: 2015-02-20T14:59:50Z [Term] id: GO:1904014 name: response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) relationship: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) created_by: sl creation_date: 2015-03-06T19:33:54Z [Term] id: GO:1904015 name: cellular response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904014 ! response to serotonin intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+) created_by: sl creation_date: 2015-03-06T19:34:00Z [Term] id: GO:1904018 name: positive regulation of vasculature development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] synonym: "activation of vascular system development" RELATED [GOC:TermGenie] synonym: "activation of vasculature development" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001944 ! positively regulates vasculature development relationship: RO:0002213 GO:0001944 ! positively regulates vasculature development created_by: sl creation_date: 2015-03-06T22:17:04Z [Term] id: GO:1904019 name: epithelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-03-06T22:27:17Z [Term] id: GO:1904026 name: regulation of collagen fibril organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "regulation of collagen fibrillogenesis" RELATED [] synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902903 ! regulation of supramolecular fiber organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030199 ! regulates collagen fibril organization relationship: RO:0002211 GO:0030199 ! regulates collagen fibril organization created_by: ae creation_date: 2015-03-12T12:36:52Z [Term] id: GO:1904027 name: negative regulation of collagen fibril organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization relationship: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization created_by: ae creation_date: 2015-03-12T12:36:59Z [Term] id: GO:1904028 name: positive regulation of collagen fibril organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization relationship: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization created_by: ae creation_date: 2015-03-12T12:37:06Z [Term] id: GO:1904035 name: regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process relationship: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-03-13T22:05:41Z [Term] id: GO:1904036 name: negative regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process relationship: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-03-13T22:05:47Z [Term] id: GO:1904037 name: positive regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process relationship: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-03-13T22:05:53Z [Term] id: GO:1904054 name: regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990705 ! regulates cholangiocyte proliferation relationship: RO:0002211 GO:1990705 ! regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-03-18T17:56:14Z [Term] id: GO:1904055 name: negative regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990705 ! negatively regulates cholangiocyte proliferation relationship: RO:0002212 GO:1990705 ! negatively regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-03-18T17:56:20Z [Term] id: GO:1904056 name: positive regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990705 ! positively regulates cholangiocyte proliferation relationship: RO:0002213 GO:1990705 ! positively regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-03-18T17:56:26Z [Term] id: GO:1904057 name: negative regulation of sensory perception of pain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "down regulation of nociception" EXACT [GOC:TermGenie] synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "downregulation of nociception" EXACT [GOC:TermGenie] synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "inhibition of nociception" NARROW [GOC:TermGenie] synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain relationship: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain created_by: sl creation_date: 2015-03-18T20:33:57Z [Term] id: GO:1904058 name: positive regulation of sensory perception of pain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "activation of nociception" NARROW [GOC:TermGenie] synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of nociception" EXACT [GOC:TermGenie] synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "upregulation of nociception" EXACT [GOC:TermGenie] synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain relationship: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain created_by: sl creation_date: 2015-03-18T20:34:03Z [Term] id: GO:1904062 name: regulation of monoatomic cation transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "regulation of cation transmembrane transport" BROAD [] is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098655 ! regulates monoatomic cation transmembrane transport relationship: RO:0002211 GO:0098655 ! regulates monoatomic cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:43Z [Term] id: GO:1904063 name: negative regulation of cation transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098655 ! negatively regulates monoatomic cation transmembrane transport relationship: RO:0002212 GO:0098655 ! negatively regulates monoatomic cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:50Z [Term] id: GO:1904064 name: positive regulation of cation transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098655 ! positively regulates monoatomic cation transmembrane transport relationship: RO:0002213 GO:0098655 ! positively regulates monoatomic cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:55Z [Term] id: GO:1904073 name: regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation relationship: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: tb creation_date: 2015-03-20T16:55:56Z [Term] id: GO:1904074 name: negative regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation relationship: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: tb creation_date: 2015-03-20T16:56:02Z [Term] id: GO:1904075 name: positive regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation relationship: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: tb creation_date: 2015-03-20T16:56:08Z [Term] id: GO:1904106 name: protein localization to microvillus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005902 ! has target end location microvillus relationship: RO:0002339 GO:0005902 ! has target end location microvillus created_by: kmv creation_date: 2015-04-01T18:14:41Z [Term] id: GO:1904145 name: negative regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1900194 ! negative regulation of oocyte maturation is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation created_by: tb creation_date: 2015-04-14T15:59:22Z [Term] id: GO:1904146 name: positive regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation created_by: tb creation_date: 2015-04-14T15:59:28Z [Term] id: GO:1904170 name: regulation of bleb assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032060 ! regulates bleb assembly relationship: RO:0002211 GO:0032060 ! regulates bleb assembly created_by: als creation_date: 2015-04-23T09:32:19Z [Term] id: GO:1904171 name: negative regulation of bleb assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032060 ! negatively regulates bleb assembly relationship: RO:0002212 GO:0032060 ! negatively regulates bleb assembly created_by: als creation_date: 2015-04-23T09:32:25Z [Term] id: GO:1904172 name: positive regulation of bleb assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032060 ! positively regulates bleb assembly relationship: RO:0002213 GO:0032060 ! positively regulates bleb assembly created_by: als creation_date: 2015-04-23T09:32:31Z [Term] id: GO:1904177 name: regulation of adipose tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie] xref: Reactome:R-HSA-9843745 "Adipogenesis" is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060612 ! regulates adipose tissue development relationship: RO:0002211 GO:0060612 ! regulates adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:01Z [Term] id: GO:1904178 name: negative regulation of adipose tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie] synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development relationship: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:07Z [Term] id: GO:1904179 name: positive regulation of adipose tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "activation of adipogenesis" RELATED [GOC:TermGenie] synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie] synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060612 ! positively regulates adipose tissue development relationship: RO:0002213 GO:0060612 ! positively regulates adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:13Z [Term] id: GO:1904192 name: regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902488 ! regulates cholangiocyte apoptotic process relationship: RO:0002211 GO:1902488 ! regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-05-06T15:25:48Z [Term] id: GO:1904193 name: negative regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902488 ! negatively regulates cholangiocyte apoptotic process relationship: RO:0002212 GO:1902488 ! negatively regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-05-06T15:25:55Z [Term] id: GO:1904194 name: positive regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902488 ! positively regulates cholangiocyte apoptotic process relationship: RO:0002213 GO:1902488 ! positively regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-05-06T15:26:00Z [Term] id: GO:1904204 name: regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] is_a: GO:0014733 ! regulation of skeletal muscle adaptation is_a: GO:0014743 ! regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy relationship: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:13Z [Term] id: GO:1904205 name: negative regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy relationship: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:19Z [Term] id: GO:1904206 name: positive regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy relationship: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:25Z [Term] id: GO:1904251 name: regulation of bile acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008206 ! regulates bile acid metabolic process relationship: RO:0002211 GO:0008206 ! regulates bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:28Z [Term] id: GO:1904252 name: negative regulation of bile acid metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008206 ! negatively regulates bile acid metabolic process relationship: RO:0002212 GO:0008206 ! negatively regulates bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:35Z [Term] id: GO:1904253 name: positive regulation of bile acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie] synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008206 ! positively regulates bile acid metabolic process relationship: RO:0002213 GO:0008206 ! positively regulates bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:40Z [Term] id: GO:1904269 name: cell leading edge cell cortex namespace: cellular_component def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030] synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie] synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie] synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie] synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie] synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie] synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0031252 ! cell leading edge relationship: part_of GO:0031252 ! cell leading edge property_value: RO:0002161 NCBITaxon:4751 created_by: kmv creation_date: 2015-05-28T19:16:03Z [Term] id: GO:1904304 name: regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] is_a: GO:0006940 ! regulation of smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014831 ! regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002211 GO:0014831 ! regulates gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:42Z [Term] id: GO:1904305 name: negative regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014831 ! negatively regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002212 GO:0014831 ! negatively regulates gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:48Z [Term] id: GO:1904306 name: positive regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014831 ! positively regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002213 GO:0014831 ! positively regulates gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:54Z [Term] id: GO:1904341 name: regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990765 ! regulates colon smooth muscle contraction relationship: RO:0002211 GO:1990765 ! regulates colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:16:58Z [Term] id: GO:1904342 name: negative regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990765 ! negatively regulates colon smooth muscle contraction relationship: RO:0002212 GO:1990765 ! negatively regulates colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:17:05Z [Term] id: GO:1904343 name: positive regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990765 ! positively regulates colon smooth muscle contraction relationship: RO:0002213 GO:1990765 ! positively regulates colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:17:11Z [Term] id: GO:1904344 name: regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990768 ! regulates gastric mucosal blood circulation relationship: RO:0002211 GO:1990768 ! regulates gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:31Z [Term] id: GO:1904345 name: negative regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903523 ! negative regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990768 ! negatively regulates gastric mucosal blood circulation relationship: RO:0002212 GO:1990768 ! negatively regulates gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:44Z [Term] id: GO:1904346 name: positive regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903524 ! positive regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990768 ! positively regulates gastric mucosal blood circulation relationship: RO:0002213 GO:1990768 ! positively regulates gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:50Z [Term] id: GO:1904347 name: regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990770 ! regulates small intestine smooth muscle contraction relationship: RO:0002211 GO:1990770 ! regulates small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:34Z [Term] id: GO:1904348 name: negative regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990770 ! negatively regulates small intestine smooth muscle contraction relationship: RO:0002212 GO:1990770 ! negatively regulates small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:40Z [Term] id: GO:1904349 name: positive regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990770 ! positively regulates small intestine smooth muscle contraction relationship: RO:0002213 GO:1990770 ! positively regulates small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:46Z [Term] id: GO:1904350 name: regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole relationship: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:36Z [Term] id: GO:1904351 name: negative regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole relationship: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:42Z [Term] id: GO:1904352 name: positive regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole relationship: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:49Z [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery relationship: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:25Z [Term] id: GO:1904376 name: negative regulation of protein localization to cell periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery relationship: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:32Z [Term] id: GO:1904377 name: positive regulation of protein localization to cell periphery namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery relationship: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:37Z [Term] id: GO:1904396 name: regulation of neuromuscular junction development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007528 ! regulates neuromuscular junction development relationship: RO:0002211 GO:0007528 ! regulates neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:42Z [Term] id: GO:1904397 name: negative regulation of neuromuscular junction development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:1904396 ! regulation of neuromuscular junction development is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development relationship: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:48Z [Term] id: GO:1904398 name: positive regulation of neuromuscular junction development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "activation of NMJ stability" RELATED [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development relationship: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:54Z [Term] id: GO:1904409 name: regulation of secretory granule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033363 ! regulates secretory granule organization relationship: RO:0002211 GO:0033363 ! regulates secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:42Z [Term] id: GO:1904410 name: negative regulation of secretory granule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization relationship: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:49Z [Term] id: GO:1904411 name: positive regulation of secretory granule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033363 ! positively regulates secretory granule organization relationship: RO:0002213 GO:0033363 ! positively regulates secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:55Z [Term] id: GO:1904412 name: regulation of cardiac ventricle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003231 ! regulates cardiac ventricle development relationship: RO:0002211 GO:0003231 ! regulates cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:15Z [Term] id: GO:1904413 name: negative regulation of cardiac ventricle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development relationship: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:21Z [Term] id: GO:1904414 name: positive regulation of cardiac ventricle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development relationship: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:27Z [Term] id: GO:1904456 name: negative regulation of neuronal action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie] synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0051970 ! negative regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential relationship: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential created_by: sl creation_date: 2015-07-09T18:02:40Z [Term] id: GO:1904457 name: positive regulation of neuronal action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "activation of generation of action potential" RELATED [GOC:TermGenie] synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0051971 ! positive regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019228 ! positively regulates neuronal action potential relationship: RO:0002213 GO:0019228 ! positively regulates neuronal action potential created_by: sl creation_date: 2015-07-09T18:02:46Z [Term] id: GO:1904484 name: cloacal gland development namespace: biological_process def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0012478 ! results in development of cloacal gland relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0012478 ! results in development of cloacal gland created_by: mr creation_date: 2015-07-15T22:14:39Z [Term] id: GO:1904491 name: protein localization to ciliary transition zone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230] synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0035869 ! has target end location ciliary transition zone relationship: RO:0002339 GO:0035869 ! has target end location ciliary transition zone property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: kmv creation_date: 2015-07-17T20:43:21Z [Term] id: GO:1904587 name: response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "response to glycoproteins" EXACT [] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input glycoprotein relationship: RO:0004009 CHEBI:17089 ! has primary input glycoprotein created_by: sl creation_date: 2015-08-20T16:46:24Z [Term] id: GO:1904588 name: cellular response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "cellular response to glycoproteins" EXACT [] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904587 ! response to glycoprotein intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input glycoprotein created_by: sl creation_date: 2015-08-20T16:46:30Z [Term] id: GO:1904606 name: fat cell apoptotic process namespace: biological_process def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416] synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000136 ! occurs in adipocyte relationship: BFO:0000066 CL:0000136 ! occurs in adipocyte property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-08-27T18:13:06Z [Term] id: GO:1904649 name: regulation of fat cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process relationship: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-08-31T20:59:28Z [Term] id: GO:1904650 name: negative regulation of fat cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process relationship: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-08-31T20:59:34Z [Term] id: GO:1904651 name: positive regulation of fat cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process relationship: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: sl creation_date: 2015-08-31T20:59:40Z [Term] id: GO:1904659 name: D-glucose transmembrane transport namespace: biological_process alt_id: GO:0015758 def: "The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] synonym: "glucose transmembrane transport" EXACT [] synonym: "glucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose created_by: vw creation_date: 2015-09-04T17:20:16Z [Term] id: GO:1904675 name: regulation of somatic stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048103 ! regulates somatic stem cell division relationship: RO:0002211 GO:0048103 ! regulates somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:22Z [Term] id: GO:1904676 name: negative regulation of somatic stem cell division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division relationship: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:28Z [Term] id: GO:1904677 name: positive regulation of somatic stem cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division relationship: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:34Z [Term] id: GO:1904680 name: peptide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015197 alt_id: GO:0015637 def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] synonym: "peptide transporter activity" RELATED [] synonym: "peptide uptake permease activity" RELATED [] xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion created_by: tb creation_date: 2015-09-22T18:50:41Z [Term] id: GO:1904691 name: negative regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044342 ! negatively regulates type B pancreatic cell proliferation relationship: RO:0002212 GO:0044342 ! negatively regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-25T15:23:38Z [Term] id: GO:1904692 name: positive regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044342 ! positively regulates type B pancreatic cell proliferation relationship: RO:0002213 GO:0044342 ! positively regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-25T15:23:44Z [Term] id: GO:1904693 name: midbrain morphogenesis namespace: biological_process def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "MB morphogenesis" BROAD [GOC:TermGenie] synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of GO:0030901 ! midbrain development relationship: part_of GO:0048854 ! brain morphogenesis relationship: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain created_by: bf creation_date: 2015-09-29T09:15:28Z [Term] id: GO:1904697 name: regulation of acinar cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990863 ! regulates acinar cell proliferation relationship: RO:0002211 GO:1990863 ! regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-30T15:19:50Z [Term] id: GO:1904698 name: negative regulation of acinar cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation relationship: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-30T15:19:57Z [Term] id: GO:1904699 name: positive regulation of acinar cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation relationship: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-30T15:20:03Z [Term] id: GO:1904705 name: regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation relationship: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-10-01T16:05:20Z [Term] id: GO:1904706 name: negative regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-10-01T16:05:26Z [Term] id: GO:1904707 name: positive regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-10-01T16:05:32Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development relationship: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 created_by: es creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development relationship: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 created_by: es creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development relationship: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 created_by: es creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904749 name: regulation of protein localization to nucleolus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus relationship: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:17Z [Term] id: GO:1904750 name: negative regulation of protein localization to nucleolus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus relationship: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:24Z [Term] id: GO:1904751 name: positive regulation of protein localization to nucleolus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus relationship: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:30Z [Term] id: GO:1904770 name: intramembranous bone morphogenesis namespace: biological_process def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686] synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie] synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone relationship: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone created_by: dos creation_date: 2015-10-28T11:46:04Z [Term] id: GO:1904776 name: regulation of protein localization to cell cortex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex relationship: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:01Z [Term] id: GO:1904777 name: negative regulation of protein localization to cell cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex relationship: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:08Z [Term] id: GO:1904778 name: positive regulation of protein localization to cell cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex relationship: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:15Z [Term] id: GO:1904817 name: serous membrane development namespace: biological_process def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "serosa development" RELATED [GOC:TermGenie] synonym: "tunica serosa development" EXACT [GOC:TermGenie] synonym: "wall of serous sac development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000042 ! results in development of serous membrane relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: RO:0002296 UBERON:0000042 ! results in development of serous membrane created_by: dph creation_date: 2015-11-17T19:00:01Z [Term] id: GO:1904818 name: visceral peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:1904820 ! peritoneum development relationship: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum created_by: dph creation_date: 2015-11-17T19:00:17Z [Term] id: GO:1904819 name: parietal peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:1904820 ! peritoneum development relationship: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum created_by: dph creation_date: 2015-11-17T19:00:24Z [Term] id: GO:1904820 name: peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritonaeum development" RELATED [GOC:TermGenie] is_a: GO:1904817 ! serous membrane development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002358 ! results in development of peritoneum relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002296 UBERON:0002358 ! results in development of peritoneum created_by: dph creation_date: 2015-11-18T17:23:51Z [Term] id: GO:1904829 name: regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation relationship: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:40Z [Term] id: GO:1904830 name: negative regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation relationship: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:47Z [Term] id: GO:1904831 name: positive regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation relationship: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:54Z [Term] id: GO:1904888 name: cranial skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227] synonym: "cranial skeleton development" NARROW [GOC:TermGenie] synonym: "craniofacial development" NARROW [PMID:11262227] synonym: "cranium development" RELATED [GOC:TermGenie] synonym: "osteocranium development" NARROW [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system created_by: bf creation_date: 2016-01-07T13:45:06Z [Term] id: GO:1904933 name: regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain relationship: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2016-02-01T13:16:11Z [Term] id: GO:1904934 name: negative regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain relationship: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2016-02-01T13:16:19Z [Term] id: GO:1904935 name: positive regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain relationship: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2016-02-01T13:16:27Z [Term] id: GO:1904942 name: regulation of cardiac ventricle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation relationship: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:16Z [Term] id: GO:1904943 name: negative regulation of cardiac ventricle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie] is_a: GO:1901211 ! negative regulation of cardiac chamber formation is_a: GO:1904413 ! negative regulation of cardiac ventricle development is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation relationship: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:24Z [Term] id: GO:1904944 name: positive regulation of cardiac ventricle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] is_a: GO:1901212 ! positive regulation of cardiac chamber formation is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation relationship: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:31Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization relationship: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization relationship: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1905038 name: regulation of membrane lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280] synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process relationship: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process created_by: tb creation_date: 2016-03-08T20:41:32Z [Term] id: GO:1905039 name: carboxylic acid transmembrane transport namespace: biological_process def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1903825 ! organic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion created_by: vw creation_date: 2016-03-09T15:33:53Z [Term] id: GO:1905063 name: regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation relationship: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:14:53Z [Term] id: GO:1905064 name: negative regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:03Z [Term] id: GO:1905065 name: positive regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:13Z [Term] id: GO:1905126 name: regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport relationship: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:31Z [Term] id: GO:1905127 name: negative regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie] synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport relationship: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:40Z [Term] id: GO:1905128 name: positive regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport relationship: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:48Z [Term] id: GO:1905139 name: apical ectodermal ridge formation namespace: biological_process def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] synonym: "AER formation" RELATED [GOC:TermGenie] synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004356 ! results in formation of anatomical entity apical ectodermal ridge relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of GO:0035107 ! appendage morphogenesis relationship: RO:0002297 UBERON:0004356 ! results in formation of anatomical entity apical ectodermal ridge created_by: dph creation_date: 2016-04-13T11:46:40Z [Term] id: GO:1905140 name: regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "regulation of AER formation" RELATED [GOC:TermGenie] synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation relationship: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:40Z [Term] id: GO:1905141 name: negative regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation relationship: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:48Z [Term] id: GO:1905142 name: positive regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "activation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation relationship: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:57Z [Term] id: GO:1905144 name: response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine relationship: RO:0004009 CHEBI:15355 ! has primary input acetylcholine created_by: dos creation_date: 2016-04-14T08:54:49Z [Term] id: GO:1905145 name: cellular response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905144 ! response to acetylcholine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input acetylcholine created_by: dos creation_date: 2016-04-14T08:54:58Z [Term] id: GO:1905147 name: regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy relationship: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:07Z [Term] id: GO:1905148 name: negative regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy relationship: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:16Z [Term] id: GO:1905149 name: positive regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy relationship: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:24Z [Term] id: GO:1905207 name: regulation of cardiocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation relationship: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:01Z [Term] id: GO:1905208 name: negative regulation of cardiocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation relationship: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:09Z [Term] id: GO:1905209 name: positive regulation of cardiocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation relationship: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:16Z [Term] id: GO:1905213 name: negative regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1902340 ! negative regulation of chromosome condensation is_a: GO:1903379 ! regulation of mitotic chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation relationship: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation created_by: vw creation_date: 2016-06-03T08:41:08Z [Term] id: GO:1905223 name: epicardium morphogenesis namespace: biological_process def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie] synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie] synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium created_by: rl creation_date: 2016-06-07T10:02:32Z [Term] id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process alt_id: GO:0045798 alt_id: GO:1903309 def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "down regulation of chromatin assembly or disassembly" RELATED [] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin assembly or disassembly" RELATED [] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin assembly or disassembly" RELATED [] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatin assembly or disassembly" RELATED [] synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006325 ! negatively regulates chromatin organization relationship: RO:0002212 GO:0006325 ! negatively regulates chromatin organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22766 xsd:anyURI created_by: pr creation_date: 2016-06-15T20:14:47Z [Term] id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process alt_id: GO:0045799 alt_id: GO:1903310 def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatin assembly or disassembly" RELATED [] synonym: "positive regulation of chromatin assembly/disassembly" RELATED [] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "stimulation of chromatin assembly or disassembly" NARROW [] synonym: "up regulation of chromatin assembly or disassembly" RELATED [] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin assembly or disassembly" RELATED [] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006325 ! positively regulates chromatin organization relationship: RO:0002213 GO:0006325 ! positively regulates chromatin organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22766 xsd:anyURI created_by: pr creation_date: 2016-06-15T20:14:56Z [Term] id: GO:1905276 name: regulation of epithelial tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072175 ! regulates epithelial tube formation relationship: RO:0002211 GO:0072175 ! regulates epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:41Z [Term] id: GO:1905277 name: negative regulation of epithelial tube formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation relationship: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:49Z [Term] id: GO:1905278 name: positive regulation of epithelial tube formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation relationship: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:57Z [Term] id: GO:1905288 name: vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034390 ! smooth muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell relationship: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell created_by: rph creation_date: 2016-06-23T13:24:20Z [Term] id: GO:1905292 name: regulation of neural crest cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation relationship: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:01Z [Term] id: GO:1905293 name: negative regulation of neural crest cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation relationship: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:09Z [Term] id: GO:1905294 name: positive regulation of neural crest cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation relationship: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:16Z [Term] id: GO:1905298 name: regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060576 ! regulates intestinal epithelial cell development relationship: RO:0002211 GO:0060576 ! regulates intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:40:47Z [Term] id: GO:1905299 name: negative regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060576 ! negatively regulates intestinal epithelial cell development relationship: RO:0002212 GO:0060576 ! negatively regulates intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:40:55Z [Term] id: GO:1905300 name: positive regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060576 ! positively regulates intestinal epithelial cell development relationship: RO:0002213 GO:0060576 ! positively regulates intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:41:02Z [Term] id: GO:1905304 name: regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902115 ! regulation of organelle assembly is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly relationship: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:01:49Z [Term] id: GO:1905305 name: negative regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly relationship: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:01:58Z [Term] id: GO:1905306 name: positive regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly relationship: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:02:07Z [Term] id: GO:1905315 name: cell proliferation involved in endocardial cushion morphogenesis namespace: biological_process def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: rl creation_date: 2016-07-12T13:56:36Z [Term] id: GO:1905330 name: regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium relationship: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:49Z [Term] id: GO:1905331 name: negative regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium relationship: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:57Z [Term] id: GO:1905332 name: positive regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium relationship: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:14:05Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0060271 ! cilium assembly relationship: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: pr creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905383 name: protein localization to presynapse namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494] synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse relationship: RO:0002339 GO:0098793 ! has target end location presynapse created_by: dos creation_date: 2016-08-18T14:42:59Z [Term] id: GO:1905384 name: regulation of protein localization to presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905383 ! regulates protein localization to presynapse relationship: RO:0002211 GO:1905383 ! regulates protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:00Z [Term] id: GO:1905385 name: negative regulation of protein localization to presynapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse relationship: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:08Z [Term] id: GO:1905386 name: positive regulation of protein localization to presynapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902474 ! positive regulation of protein localization to synapse is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse relationship: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:21Z [Term] id: GO:1905432 name: regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:56:47Z [Term] id: GO:1905433 name: negative regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:56:55Z [Term] id: GO:1905434 name: positive regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:57:02Z [Term] id: GO:1905453 name: regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation relationship: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:18Z [Term] id: GO:1905454 name: negative regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation relationship: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:26Z [Term] id: GO:1905455 name: positive regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation relationship: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:33Z [Term] id: GO:1905459 name: regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: rph creation_date: 2016-09-19T11:33:54Z [Term] id: GO:1905460 name: negative regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: rph creation_date: 2016-09-19T11:34:03Z [Term] id: GO:1905461 name: positive regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: rph creation_date: 2016-09-19T11:34:10Z [Term] id: GO:1905475 name: regulation of protein localization to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072657 ! regulates protein localization to membrane relationship: RO:0002211 GO:0072657 ! regulates protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:03Z [Term] id: GO:1905476 name: negative regulation of protein localization to membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane relationship: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:10Z [Term] id: GO:1905477 name: positive regulation of protein localization to membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane relationship: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:18Z [Term] id: GO:1905492 name: positive regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie] synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve relationship: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve created_by: hbye creation_date: 2016-09-23T14:11:52Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009566 ! positively regulates fertilization relationship: RO:0002213 GO:0009566 ! positively regulates fertilization created_by: pr creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905553 name: regulation of blood vessel branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis relationship: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis created_by: nc creation_date: 2016-10-12T14:19:33Z [Term] id: GO:1905554 name: negative regulation of blood vessel branching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis relationship: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/29454 xsd:anyURI created_by: nc creation_date: 2016-10-12T14:19:41Z [Term] id: GO:1905555 name: positive regulation of blood vessel branching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis relationship: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis created_by: nc creation_date: 2016-10-12T14:19:49Z [Term] id: GO:1905557 name: regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly relationship: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly created_by: hbye creation_date: 2016-10-14T13:14:57Z [Term] id: GO:1905558 name: negative regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly relationship: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly created_by: hbye creation_date: 2016-10-14T13:15:08Z [Term] id: GO:1905559 name: positive regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly relationship: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly created_by: hbye creation_date: 2016-10-14T13:15:17Z [Term] id: GO:1905562 name: regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] is_a: GO:0001936 ! regulation of endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation relationship: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: nc creation_date: 2016-10-17T09:24:17Z [Term] id: GO:1905563 name: negative regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0001937 ! negative regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation relationship: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: nc creation_date: 2016-10-17T09:24:26Z [Term] id: GO:1905564 name: positive regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0001938 ! positive regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation relationship: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: nc creation_date: 2016-10-17T09:24:35Z [Term] id: GO:1905606 name: regulation of presynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] subset: goslim_synapse synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099054 ! regulates presynapse assembly relationship: RO:0002211 GO:0099054 ! regulates presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:13Z [Term] id: GO:1905607 name: negative regulation of presynapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly relationship: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:20Z [Term] id: GO:1905608 name: positive regulation of presynapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie] synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099054 ! positively regulates presynapse assembly relationship: RO:0002213 GO:0099054 ! positively regulates presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:28Z [Term] id: GO:1905627 name: regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process relationship: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:20Z [Term] id: GO:1905628 name: negative regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process relationship: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:28Z [Term] id: GO:1905629 name: positive regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of serotonin formation" NARROW [GOC:TermGenie] synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process relationship: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:36Z [Term] id: GO:1905634 name: regulation of protein localization to chromatin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071168 ! regulates protein localization to chromatin relationship: RO:0002211 GO:0071168 ! regulates protein localization to chromatin created_by: pga creation_date: 2016-11-01T16:33:52Z [Term] id: GO:1905651 name: regulation of artery morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048844 ! regulates artery morphogenesis relationship: RO:0002211 GO:0048844 ! regulates artery morphogenesis created_by: rph creation_date: 2016-11-09T12:19:37Z [Term] id: GO:1905652 name: negative regulation of artery morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:1905651 ! regulation of artery morphogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis relationship: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis created_by: rph creation_date: 2016-11-09T12:19:53Z [Term] id: GO:1905653 name: positive regulation of artery morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie] synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis relationship: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis created_by: rph creation_date: 2016-11-09T12:20:01Z [Term] id: GO:1905690 name: nucleus disassembly namespace: biological_process def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] is_a: GO:0006997 ! nucleus organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005634 ! results in disassembly of nucleus relationship: RO:0002590 GO:0005634 ! results in disassembly of nucleus created_by: pr creation_date: 2016-11-14T13:38:57Z [Term] id: GO:1905720 name: cytoplasmic microtubule bundle namespace: cellular_component def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie] is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm created_by: mah creation_date: 2016-11-24T16:52:02Z [Term] id: GO:1905755 name: protein localization to cytoplasmic microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule relationship: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule created_by: mah creation_date: 2016-12-12T15:31:07Z [Term] id: GO:1905770 name: regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation relationship: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation created_by: rph creation_date: 2016-12-21T12:44:13Z [Term] id: GO:1905771 name: negative regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation relationship: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation created_by: rph creation_date: 2016-12-21T12:44:23Z [Term] id: GO:1905772 name: positive regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation relationship: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation created_by: rph creation_date: 2016-12-21T12:44:32Z [Term] id: GO:1905806 name: regulation of synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] subset: goslim_synapse synonym: "regulation of synapse clearance" EXACT [] synonym: "regulation of synapse disassembly" EXACT syngo_official_label [] synonym: "regulation of synapse elimination" EXACT [] synonym: "regulation of synapse removal" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098883 ! regulates synapse pruning relationship: RO:0002211 GO:0098883 ! regulates synapse pruning created_by: tb creation_date: 2017-01-11T22:03:15Z [Term] id: GO:1905807 name: negative regulation of synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098883 ! negatively regulates synapse pruning relationship: RO:0002212 GO:0098883 ! negatively regulates synapse pruning created_by: tb creation_date: 2017-01-11T22:03:24Z [Term] id: GO:1905808 name: positive regulation of synapse pruning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098883 ! positively regulates synapse pruning relationship: RO:0002213 GO:0098883 ! positively regulates synapse pruning created_by: tb creation_date: 2017-01-11T22:03:33Z [Term] id: GO:1905809 name: negative regulation of synapse organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse development" EXACT [GOC:TermGenie] synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse development" NARROW [GOC:TermGenie] synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050808 ! negatively regulates synapse organization relationship: RO:0002212 GO:0050808 ! negatively regulates synapse organization created_by: tb creation_date: 2017-01-11T22:03:41Z [Term] id: GO:1905821 name: positive regulation of chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030261 ! positively regulates chromosome condensation relationship: RO:0002213 GO:0030261 ! positively regulates chromosome condensation created_by: bhm creation_date: 2017-01-13T14:13:44Z [Term] id: GO:1905833 name: negative regulation of microtubule nucleation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031115 ! negative regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation relationship: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation created_by: hbye creation_date: 2017-01-17T12:00:56Z [Term] id: GO:1905871 name: regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge relationship: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge created_by: sl creation_date: 2017-01-27T19:34:55Z [Term] id: GO:1905872 name: negative regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge relationship: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge created_by: sl creation_date: 2017-01-27T19:35:04Z [Term] id: GO:1905873 name: positive regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge relationship: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge created_by: sl creation_date: 2017-01-27T19:35:13Z [Term] id: GO:1905879 name: regulation of oogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048477 ! regulates oogenesis relationship: RO:0002211 GO:0048477 ! regulates oogenesis created_by: hbye creation_date: 2017-01-31T09:31:05Z [Term] id: GO:1905880 name: negative regulation of oogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048477 ! negatively regulates oogenesis relationship: RO:0002212 GO:0048477 ! negatively regulates oogenesis created_by: hbye creation_date: 2017-01-31T09:31:15Z [Term] id: GO:1905881 name: positive regulation of oogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of oogenesis" NARROW [GOC:TermGenie] synonym: "activation of ovum development" NARROW [GOC:TermGenie] synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048477 ! positively regulates oogenesis relationship: RO:0002213 GO:0048477 ! positively regulates oogenesis created_by: hbye creation_date: 2017-01-31T09:31:23Z [Term] id: GO:1905899 name: regulation of smooth muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development relationship: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development created_by: bhm creation_date: 2017-02-01T14:31:16Z [Term] id: GO:1905900 name: negative regulation of smooth muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:1901862 ! negative regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development relationship: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development created_by: bhm creation_date: 2017-02-01T14:31:24Z [Term] id: GO:1905901 name: positive regulation of smooth muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:1901863 ! positive regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development relationship: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development created_by: bhm creation_date: 2017-02-01T14:31:33Z [Term] id: GO:1905902 name: regulation of mesoderm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001707 ! regulates mesoderm formation relationship: RO:0002211 GO:0001707 ! regulates mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:20Z [Term] id: GO:1905903 name: negative regulation of mesoderm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation relationship: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:29Z [Term] id: GO:1905904 name: positive regulation of mesoderm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001707 ! positively regulates mesoderm formation relationship: RO:0002213 GO:0001707 ! positively regulates mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:38Z [Term] id: GO:1905921 name: regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process relationship: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process created_by: bc creation_date: 2017-02-08T13:08:30Z [Term] id: GO:1905922 name: negative regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process relationship: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process created_by: bc creation_date: 2017-02-08T13:08:39Z [Term] id: GO:1905923 name: positive regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process relationship: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process created_by: bc creation_date: 2017-02-08T13:08:48Z [Term] id: GO:1905936 name: regulation of germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036093 ! regulates germ cell proliferation relationship: RO:0002211 GO:0036093 ! regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: hbye creation_date: 2017-02-09T14:51:31Z [Term] id: GO:1905937 name: negative regulation of germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation relationship: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: hbye creation_date: 2017-02-09T14:51:41Z [Term] id: GO:1905938 name: positive regulation of germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation relationship: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: hbye creation_date: 2017-02-09T14:51:51Z [Term] id: GO:1905939 name: regulation of gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008406 ! regulates gonad development relationship: RO:0002211 GO:0008406 ! regulates gonad development created_by: hbye creation_date: 2017-02-09T17:01:50Z [Term] id: GO:1905940 name: negative regulation of gonad development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of gonad development" EXACT [GOC:TermGenie] synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of gonad development" NARROW [GOC:TermGenie] synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008406 ! negatively regulates gonad development relationship: RO:0002212 GO:0008406 ! negatively regulates gonad development created_by: hbye creation_date: 2017-02-09T17:01:59Z [Term] id: GO:1905941 name: positive regulation of gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of gonad development" NARROW [GOC:TermGenie] synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of gonad development" EXACT [GOC:TermGenie] synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008406 ! positively regulates gonad development relationship: RO:0002213 GO:0008406 ! positively regulates gonad development created_by: hbye creation_date: 2017-02-09T17:02:08Z [Term] id: GO:1905952 name: regulation of lipid localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010876 ! regulates lipid localization relationship: RO:0002211 GO:0010876 ! regulates lipid localization created_by: rz creation_date: 2017-02-21T12:12:22Z [Term] id: GO:1905953 name: negative regulation of lipid localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010876 ! negatively regulates lipid localization relationship: RO:0002212 GO:0010876 ! negatively regulates lipid localization created_by: rz creation_date: 2017-02-21T12:12:41Z [Term] id: GO:1905954 name: positive regulation of lipid localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] synonym: "activation of lipid localization" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010876 ! positively regulates lipid localization relationship: RO:0002213 GO:0010876 ! positively regulates lipid localization created_by: rz creation_date: 2017-02-21T12:12:49Z [Term] id: GO:1905955 name: negative regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis relationship: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis created_by: rph creation_date: 2017-02-21T15:17:31Z [Term] id: GO:1905956 name: positive regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis relationship: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis created_by: rph creation_date: 2017-02-21T15:17:39Z [Term] id: GO:1990009 name: retinal cell apoptotic process namespace: biological_process alt_id: GO:0046674 def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] synonym: "induction of retinal programmed cell death" RELATED [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009004 ! occurs in retinal cell relationship: BFO:0000066 CL:0009004 ! occurs in retinal cell property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-12-12T10:15:08Z [Term] id: GO:1990010 name: compound eye retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768] is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell relationship: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2012-12-12T10:21:07Z [Term] id: GO:1990182 name: exosomal secretion namespace: biological_process def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898] synonym: "exosomal protein secretion" NARROW [PMID:18617898] synonym: "exosomal secretory pathway" EXACT [PMID:18617898] synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd] synonym: "multi-vesicular body fusion with plasma membrane" EXACT [] synonym: "secretion of exosome" EXACT [PMID:18617898] is_a: GO:0006887 ! exocytosis is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006887 ! exocytosis intersection_of: RO:0004009 GO:0070062 ! has primary input extracellular exosome relationship: part_of GO:0097734 ! extracellular exosome biogenesis relationship: RO:0004009 GO:0070062 ! has primary input extracellular exosome property_value: RO:0002161 NCBITaxon:4890 created_by: hjd creation_date: 2013-09-04T21:08:14Z [Term] id: GO:1990280 name: RNA localization to chromatin namespace: biological_process def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] synonym: "RNA localisation to chromatin" EXACT [] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin created_by: mah creation_date: 2014-01-30T15:55:34Z [Term] id: GO:1990351 name: transporter complex namespace: cellular_component def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: capable_of GO:0005215 ! transporter activity relationship: capable_of GO:0005215 ! transporter activity created_by: bhm creation_date: 2014-03-26T14:23:27Z [Term] id: GO:1990502 name: dense core granule maturation namespace: biological_process def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] synonym: "dense core vesicle maturation" EXACT [] is_a: GO:0061792 ! secretory granule maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0031045 ! results in maturation of dense core granule relationship: RO:0002299 GO:0031045 ! results in maturation of dense core granule property_value: RO:0002161 NCBITaxon:4890 created_by: kmv creation_date: 2014-09-30T20:35:11Z [Term] id: GO:1990705 name: cholangiocyte proliferation namespace: biological_process def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010] synonym: "hepatoblast proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000488 ! acts on population of cholangiocyte relationship: RO:0012003 CL:1000488 ! acts on population of cholangiocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-16T23:23:50Z [Term] id: GO:1990748 name: cellular detoxification namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] is_a: GO:0009987 ! cellular process is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: part_of GO:0097237 ! cellular response to toxic substance created_by: vw creation_date: 2015-05-18T16:17:46Z [Term] id: GO:1990765 name: colon smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253] is_a: GO:0006939 ! smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0001155 ! occurs in colon relationship: BFO:0000066 UBERON:0001155 ! occurs in colon relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0014827 ! intestine smooth muscle contraction created_by: sl creation_date: 2015-06-10T18:29:21Z [Term] id: GO:1990768 name: gastric mucosal blood circulation namespace: biological_process def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] synonym: "stomach mucosal blood circulation" EXACT [] is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa relationship: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: sl creation_date: 2015-06-10T20:11:09Z [Term] id: GO:1990770 name: small intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] is_a: GO:0006939 ! smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0002108 ! occurs in small intestine relationship: BFO:0000066 UBERON:0002108 ! occurs in small intestine relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0014827 ! intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T18:02:33Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery relationship: RO:0002339 GO:0071944 ! has target end location cell periphery creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990849 name: vacuolar localization namespace: biological_process def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] synonym: "maintenance of vacuolar localization" EXACT [] synonym: "maintenance of vacuolar location" NARROW [] synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole relationship: RO:0004009 GO:0005773 ! has primary input vacuole property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22182 xsd:anyURI created_by: mcc creation_date: 2015-09-10T08:16:02Z [Term] id: GO:1990863 name: acinar cell proliferation namespace: biological_process def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] synonym: "acinic cell proliferation" EXACT [] synonym: "acinous cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-25T14:26:09Z [Term] id: GO:1990874 name: vascular associated smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] synonym: "vascular smooth muscle cell proliferation" EXACT [] synonym: "VSMC proliferation" EXACT [] is_a: GO:0048659 ! smooth muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell property_value: RO:0002161 NCBITaxon:4751 created_by: sl creation_date: 2015-09-29T16:34:59Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component alt_id: GO:0030529 alt_id: GO:1990903 def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: has_part CHEBI:33697 ! ribonucleic acid created_by: pr creation_date: 2015-11-19T12:26:37Z [Term] id: GO:1990917 name: ooplasm namespace: cellular_component def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of CL:0000025 ! egg cell relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of CL:0000025 ! egg cell created_by: sl creation_date: 2015-12-10T21:40:16Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007275 ! regulates multicellular organism development relationship: RO:0002211 GO:0007275 ! regulates multicellular organism development created_by: tb creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis created_by: tb creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division relationship: RO:0002211 GO:0017145 ! regulates stem cell division created_by: tb creation_date: 2010-08-05T11:34:53Z [Term] id: GO:2000074 name: regulation of type B pancreatic cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] xref: Reactome:R-HSA-211163 "AKT-mediated inactivation of FOXO1A" is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development relationship: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development created_by: tb creation_date: 2010-08-27T11:19:37Z [Term] id: GO:2000077 name: negative regulation of type B pancreatic cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development relationship: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development created_by: tb creation_date: 2010-08-27T11:21:17Z [Term] id: GO:2000078 name: positive regulation of type B pancreatic cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development relationship: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development created_by: tb creation_date: 2010-08-27T11:21:19Z [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of leukocyte apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2010-09-15T01:42:05Z [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2010-09-15T01:42:09Z [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2010-09-15T01:42:12Z [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity created_by: dph creation_date: 2010-09-16T01:22:36Z [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-09-29T12:43:53Z [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-09-29T12:43:55Z [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-09-29T12:43:57Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] xref: Reactome:R-HSA-6785631 "ERBB2 Regulates Cell Motility" is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048870 ! regulates cell motility relationship: RO:0002211 GO:0048870 ! regulates cell motility created_by: mah creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048870 ! negatively regulates cell motility relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility created_by: mah creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048870 ! positively regulates cell motility relationship: RO:0002213 GO:0048870 ! positively regulates cell motility created_by: mah creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve created_by: rl creation_date: 2010-10-07T12:07:54Z [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve created_by: rl creation_date: 2010-10-07T12:07:56Z [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-10-13T12:40:41Z [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-10-13T12:40:43Z [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2010-10-13T12:40:45Z [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis created_by: dph creation_date: 2010-10-13T12:46:31Z [Term] id: GO:2000194 name: regulation of female gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "regulation of ovarian development" EXACT [GOC:obol] synonym: "regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008585 ! regulates female gonad development relationship: RO:0002211 GO:0008585 ! regulates female gonad development created_by: yaf creation_date: 2010-10-19T10:45:34Z [Term] id: GO:2000195 name: negative regulation of female gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "negative regulation of ovarian development" EXACT [GOC:obol] synonym: "negative regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008585 ! negatively regulates female gonad development relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad development created_by: yaf creation_date: 2010-10-19T10:45:38Z [Term] id: GO:2000196 name: positive regulation of female gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "positive regulation of ovarian development" EXACT [GOC:obol] synonym: "positive regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development created_by: yaf creation_date: 2010-10-19T10:45:41Z [Term] id: GO:2000226 name: regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation relationship: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation created_by: mah creation_date: 2010-11-09T03:43:37Z [Term] id: GO:2000227 name: negative regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation relationship: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation created_by: mah creation_date: 2010-11-09T03:43:40Z [Term] id: GO:2000228 name: positive regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation relationship: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation created_by: mah creation_date: 2010-11-09T03:43:42Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process relationship: RO:0002211 GO:0022414 ! regulates reproductive process created_by: mah creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022414 ! negatively regulates reproductive process relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process created_by: mah creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022414 ! positively regulates reproductive process relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process created_by: mah creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity created_by: vw creation_date: 2010-11-11T11:40:34Z [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "regulation of fibroblast apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: jl creation_date: 2010-11-23T01:07:23Z [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "negative regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: jl creation_date: 2010-11-23T01:07:27Z [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "positive regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: jl creation_date: 2010-11-23T01:07:29Z [Term] id: GO:2000282 name: regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process relationship: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/28908 xsd:anyURI created_by: vw creation_date: 2010-12-10T11:54:19Z [Term] id: GO:2000283 name: negative regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process relationship: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:23Z [Term] id: GO:2000284 name: positive regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process relationship: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:27Z [Term] id: GO:2000287 name: positive regulation of myotome development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061055 ! positively regulates myotome development relationship: RO:0002213 GO:0061055 ! positively regulates myotome development created_by: rl creation_date: 2010-12-16T05:17:15Z [Term] id: GO:2000288 name: positive regulation of myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: rl creation_date: 2010-12-16T05:20:52Z [Term] id: GO:2000290 name: regulation of myotome development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061055 ! regulates myotome development relationship: RO:0002211 GO:0061055 ! regulates myotome development created_by: mah creation_date: 2010-12-20T10:22:05Z [Term] id: GO:2000291 name: regulation of myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: mah creation_date: 2010-12-20T10:34:26Z [Term] id: GO:2000292 name: regulation of defecation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0044062 ! regulation of excretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030421 ! regulates defecation relationship: RO:0002211 GO:0030421 ! regulates defecation created_by: bf creation_date: 2010-12-21T09:23:08Z [Term] id: GO:2000293 name: negative regulation of defecation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030421 ! negatively regulates defecation relationship: RO:0002212 GO:0030421 ! negatively regulates defecation created_by: bf creation_date: 2010-12-21T09:23:13Z [Term] id: GO:2000294 name: positive regulation of defecation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030421 ! positively regulates defecation relationship: RO:0002213 GO:0030421 ! positively regulates defecation created_by: bf creation_date: 2010-12-21T09:23:16Z [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "regulation of endothelial cell apoptosis" NARROW [] synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2011-02-03T10:43:16Z [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of endothelial cell apoptosis" NARROW [] synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2011-02-03T10:43:20Z [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of endothelial cell apoptosis" NARROW [] synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: mah creation_date: 2011-02-03T10:43:23Z [Term] id: GO:2000374 name: regulation of oxygen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process created_by: mah creation_date: 2011-02-11T02:03:32Z [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic process relationship: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic process created_by: mah creation_date: 2011-02-11T02:03:44Z [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic process relationship: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic process created_by: mah creation_date: 2011-02-11T02:03:52Z [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development relationship: RO:0002211 GO:0007498 ! regulates mesoderm development created_by: vk creation_date: 2011-02-15T03:09:46Z [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007498 ! negatively regulates mesoderm development relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development created_by: vk creation_date: 2011-02-15T03:10:02Z [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007498 ! positively regulates mesoderm development relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development created_by: vk creation_date: 2011-02-15T03:10:12Z [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development relationship: RO:0002211 GO:0007398 ! regulates ectoderm development created_by: vk creation_date: 2011-02-15T03:17:10Z [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007398 ! negatively regulates ectoderm development relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development created_by: vk creation_date: 2011-02-15T03:17:27Z [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007398 ! positively regulates ectoderm development relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development created_by: vk creation_date: 2011-02-15T03:17:39Z [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2011-03-18T02:18:34Z [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2011-03-18T02:19:22Z [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: bf creation_date: 2011-03-18T02:19:54Z [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007369 ! negatively regulates gastrulation relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation created_by: yaf creation_date: 2011-04-01T04:10:08Z [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007369 ! positively regulates gastrulation relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation created_by: yaf creation_date: 2011-04-01T04:10:15Z [Term] id: GO:2000647 name: negative regulation of stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2011-04-27T01:04:22Z [Term] id: GO:2000648 name: positive regulation of stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: dph creation_date: 2011-04-27T01:04:25Z [Term] id: GO:2000649 name: regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015081 ! regulates sodium ion transmembrane transporter activity relationship: RO:0002211 GO:0015081 ! regulates sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:42:53Z [Term] id: GO:2000650 name: negative regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015081 ! negatively regulates sodium ion transmembrane transporter activity relationship: RO:0002212 GO:0015081 ! negatively regulates sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:42:57Z [Term] id: GO:2000651 name: positive regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015081 ! positively regulates sodium ion transmembrane transporter activity relationship: RO:0002213 GO:0015081 ! positively regulates sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:43:00Z [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T10:56:17Z [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "negative regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T10:56:21Z [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "positive regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T10:56:24Z [Term] id: GO:2000674 name: regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process relationship: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T11:51:09Z [Term] id: GO:2000675 name: negative regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process relationship: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T11:51:12Z [Term] id: GO:2000676 name: positive regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process relationship: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-05-09T11:51:15Z [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:01Z [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:06Z [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:09Z [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:06Z [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:11Z [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:15Z [Term] id: GO:2000736 name: regulation of stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:16Z [Term] id: GO:2000737 name: negative regulation of stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:20Z [Term] id: GO:2000738 name: positive regulation of stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:23Z [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-06-24T01:53:50Z [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-06-24T01:53:53Z [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-06-24T01:53:56Z [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-06-25T07:22:38Z [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-06-25T07:22:42Z [Term] id: GO:2000818 name: negative regulation of myoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 created_by: pr creation_date: 2011-07-12T03:06:04Z [Term] id: GO:2000826 name: regulation of heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis created_by: vk creation_date: 2011-07-19T10:08:58Z [Term] id: GO:2000831 name: regulation of steroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035929 ! regulates steroid hormone secretion relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion created_by: bf creation_date: 2011-07-26T08:38:46Z [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion created_by: bf creation_date: 2011-07-26T08:38:50Z [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion created_by: bf creation_date: 2011-07-26T08:38:51Z [Term] id: GO:2000834 name: regulation of androgen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion relationship: RO:0002211 GO:0035935 ! regulates androgen secretion created_by: bf creation_date: 2011-07-26T08:39:45Z [Term] id: GO:2000835 name: negative regulation of androgen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035935 ! negatively regulates androgen secretion relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion created_by: bf creation_date: 2011-07-26T08:39:48Z [Term] id: GO:2000836 name: positive regulation of androgen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion created_by: bf creation_date: 2011-07-26T08:39:51Z [Term] id: GO:2001012 name: mesenchymal cell differentiation involved in renal system development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol] synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0072001 ! renal system development relationship: part_of GO:0072001 ! renal system development created_by: yaf creation_date: 2011-08-09T04:05:14Z [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:37Z [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:41Z [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:44Z [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process relationship: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: yaf creation_date: 2011-09-08T02:49:59Z [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process relationship: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: yaf creation_date: 2011-09-08T02:50:05Z [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process relationship: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 created_by: yaf creation_date: 2011-09-08T02:50:09Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process relationship: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001212 name: regulation of vasculogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001570 ! regulates vasculogenesis relationship: RO:0002211 GO:0001570 ! regulates vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:31Z [Term] id: GO:2001213 name: negative regulation of vasculogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis relationship: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:36Z [Term] id: GO:2001214 name: positive regulation of vasculogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001570 ! positively regulates vasculogenesis relationship: RO:0002213 GO:0001570 ! positively regulates vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:39Z [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway relationship: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-11-24T01:20:49Z [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway relationship: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-11-24T01:20:54Z [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway relationship: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 created_by: pr creation_date: 2011-11-24T01:20:58Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051276 ! negatively regulates chromosome organization relationship: RO:0002212 GO:0051276 ! negatively regulates chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051276 ! positively regulates chromosome organization relationship: RO:0002213 GO:0051276 ! positively regulates chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:26Z [Term] id: IAO:0000027 name: data item is_a: IAO:0000030 ! information content entity [Term] id: IAO:0000030 name: information content entity [Term] id: IAO:0000078 name: curation status specification def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: editor_note "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string property_value: IAO:0000111 "curation status specification" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string property_value: IAO:0000119 GROUP:OBI: xsd:string property_value: IAO:0000119 "OBI_0000266" xsd:string [Term] id: IAO:0000102 name: data about an ontology part def: "Data about an ontology part is a data item about a part of an ontology, for example a term" [] is_a: IAO:0000027 ! data item [Term] id: IAO:0000225 name: obsolescence reason specification def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: editor_note "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string [Term] id: IAO:0000409 name: denotator type def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string [Term] id: NBO:0000001 name: body part movement namespace: behavior_ontology def: "A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]" [] synonym: "stationary movement" EXACT [] is_a: NBO:0000338 ! kinesthetic behavior created_by: George Gkoutos [Term] id: NBO:0000007 name: mouth movement namespace: behavior_ontology def: "The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]" [] synonym: "mouth part movement" NARROW [] synonym: "other moved mouth parts" NARROW [] is_a: NBO:0000001 ! body part movement created_by: George Gkoutos [Term] id: NBO:0000073 name: chewing namespace: behavior_ontology def: "The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]" [] synonym: "chew" EXACT [] synonym: "gnaw" EXACT [] synonym: "mastication" EXACT [] is_a: NBO:0000747 ! jaw movement created_by: George Gkoutos [Term] id: NBO:0000313 name: behavior process namespace: behavior_ontology alt_id: NBO:0000000 def: "\"The action, reaction, or performance of an organism in response to external or internal stimuli.\" [GO:GO\\:0007610]" [] synonym: "behavior" EXACT [] synonym: "behaviour" EXACT [] is_a: GO:0007610 ! behavior created_by: George Gkoutos [Term] id: NBO:0000338 name: kinesthetic behavior namespace: behavior_ontology def: "\"Movement behavior of the body or its parts.\"" [] is_a: NBO:0000313 ! behavior process created_by: George Gkoutos [Term] id: NBO:0000747 name: jaw movement namespace: behavior_ontology is_a: NBO:0000007 ! mouth movement created_by: gkoutos [Term] id: NBO:0001786 name: regulation of behavior def: "\"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.\" [GO:0050795]" [] is_a: NBO:0000313 ! behavior process relationship: RO:0002211 NBO:0000313 ! regulates behavior process created_by: George Gkoutos [Term] id: NCBITaxon:1 name: root namespace: ncbi_taxonomy synonym: "all" RELATED synonym [] xref: GC_ID:1 xref: PMID:30365038 xref: PMID:32761142 [Term] id: NCBITaxon:10066 name: Muridae namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15371245 is_a: NCBITaxon:337687 ! Muroidea [Term] id: NCBITaxon:10088 name: Mus namespace: ncbi_taxonomy synonym: "mice" EXACT genbank_common_name [] synonym: "mouse" EXACT OMO:0003003 [] synonym: "Mus" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:39107 ! Murinae disjoint_from: NCBITaxon:10114 ! Rattus [Term] id: NCBITaxon:10090 name: Mus musculus namespace: ncbi_taxonomy alt_id: NCBITaxon:85055 synonym: "house mouse" EXACT genbank_common_name [] synonym: "mouse" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:862507 ! Mus [Term] id: NCBITaxon:10114 name: Rattus namespace: ncbi_taxonomy synonym: "rat" EXACT OMO:0003003 [] synonym: "rats" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:39107 ! Murinae [Term] id: NCBITaxon:105389 name: Sedentaria namespace: ncbi_taxonomy synonym: "Palpata" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:6341 ! Polychaeta [Term] id: NCBITaxon:105391 name: Canalipalpata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:105389 ! Sedentaria [Term] id: NCBITaxon:110814 name: Xenoturbellida namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1312402 ! Xenacoelomorpha disjoint_from: NCBITaxon:147099 ! Acoelomorpha [Term] id: NCBITaxon:110815 name: Xenoturbella namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1547233 ! Xenoturbellidae [Term] id: NCBITaxon:117565 name: Myxini namespace: ncbi_taxonomy synonym: "Agnatha" RELATED in_part [] synonym: "fish" EXACT OMO:0003003 [] synonym: "fishes" EXACT OMO:0003003 [] synonym: "Hyperotreti" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:1476529 ! Cyclostomata [Term] id: NCBITaxon:117570 name: Teleostomi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata disjoint_from: NCBITaxon:7777 ! Chondrichthyes [Term] id: NCBITaxon:117571 name: Euteleostomi namespace: ncbi_taxonomy alt_id: NCBITaxon:40673 synonym: "bony vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi [Term] id: NCBITaxon:119089 name: Chromadorea namespace: ncbi_taxonomy alt_id: NCBITaxon:27837 synonym: "Adenophorea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:6231 ! Nematoda [Term] id: NCBITaxon:1206794 name: Ecdysozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia disjoint_from: NCBITaxon:2697495 ! Spiralia [Term] id: NCBITaxon:1206795 name: Lophotrochozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2697495 ! Spiralia [Term] id: NCBITaxon:124129 name: Acipenserinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7900 ! Acipenseridae [Term] id: NCBITaxon:124130 name: Acipenserini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:124129 ! Acipenserinae [Term] id: NCBITaxon:1312402 name: Xenacoelomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria disjoint_from: NCBITaxon:33317 ! Protostomia disjoint_from: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:131567 name: cellular organisms namespace: ncbi_taxonomy synonym: "biota" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:1329799 name: Archelosauria namespace: ncbi_taxonomy synonym: "Archosauria-Testudines" RELATED synonym [] synonym: "Testudines + Archosauria group" RELATED synonym [] xref: GC_ID:1 xref: PMID:22839753 xref: PMID:25450099 is_a: NCBITaxon:32561 ! Sauria disjoint_from: NCBITaxon:8504 ! Lepidosauria [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:1437010 name: Boreoeutheria namespace: ncbi_taxonomy synonym: "Boreotheria" RELATED synonym [] xref: GC_ID:1 xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria [Term] id: NCBITaxon:147099 name: Acoelomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1312402 ! Xenacoelomorpha [Term] id: NCBITaxon:1476529 name: Cyclostomata namespace: ncbi_taxonomy synonym: "Agnatha" RELATED synonym [] synonym: "jawless vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata disjoint_from: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:1489341 name: Osteoglossocephalai namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32443 ! Teleostei [Term] id: NCBITaxon:1547233 name: Xenoturbellidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:110814 ! Xenoturbellida [Term] id: NCBITaxon:186622 name: Acipenseroidei namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7899 ! Acipenseriformes [Term] id: NCBITaxon:186623 name: Actinopteri namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:186625 name: Clupeocephala namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1489341 ! Osteoglossocephalai [Term] id: NCBITaxon:186626 name: Otophysi namespace: ncbi_taxonomy synonym: "Otophysa" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:32519 ! Ostariophysi [Term] id: NCBITaxon:186627 name: Cypriniphysae namespace: ncbi_taxonomy synonym: "Cypriniphysi" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:186626 ! Otophysi [Term] id: NCBITaxon:186634 name: Otomorpha namespace: ncbi_taxonomy synonym: "Ostarioclupeomorpha" RELATED synonym [] synonym: "Otocephala" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:186625 ! Clupeocephala [Term] id: NCBITaxon:1963758 name: Myomorpha namespace: ncbi_taxonomy synonym: "mice and others" EXACT genbank_common_name [] synonym: "Sciurognathi" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:9989 ! Rodentia [Term] id: NCBITaxon:197562 name: Pancrustacea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:10874751 xref: PMID:11557979 is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata namespace: ncbi_taxonomy synonym: "mandibulates" EXACT OMO:0003003 [] xref: GC_ID:1 xref: PMID:11557979 xref: PMID:9727836 is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:207598 name: Homininae namespace: ncbi_taxonomy synonym: "Homo/Pan/Gorilla group" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:9604 ! Hominidae [Term] id: NCBITaxon:2301116 name: Rhabditina namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6236 ! Rhabditida [Term] id: NCBITaxon:2301119 name: Rhabditomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2301116 ! Rhabditina [Term] id: NCBITaxon:262014 name: Xenopus namespace: ncbi_taxonomy synonym: "Xenopus" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:8353 ! Xenopus [Term] id: NCBITaxon:2697495 name: Spiralia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:2743709 name: Danionidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:30727 ! Cyprinoidei [Term] id: NCBITaxon:2743711 name: Danioninae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2743709 ! Danionidae [Term] id: NCBITaxon:2759 name: Eukaryota namespace: ncbi_taxonomy synonym: "Eucarya" RELATED synonym [] synonym: "Eucaryotae" RELATED synonym [] synonym: "eucaryotes" EXACT genbank_common_name [] synonym: "Eukarya" RELATED synonym [] synonym: "Eukaryotae" RELATED synonym [] synonym: "eukaryotes" EXACT OMO:0003003 [] synonym: "eukaryotes" RELATED blast_name [] xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:30319 name: Pipoidea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8342 ! Anura [Term] id: NCBITaxon:30727 name: Cyprinoidei namespace: ncbi_taxonomy synonym: "Cyprinoidea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:7952 ! Cypriniformes [Term] id: NCBITaxon:3073799 name: Columbimorphae namespace: ncbi_taxonomy synonym: "pigeons, sandgrouse & allies" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:3078114 ! Neoaves [Term] id: NCBITaxon:3078114 name: Neoaves namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8825 ! Neognathae [Term] id: NCBITaxon:314146 name: Euarchontoglires namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:12878460 xref: PMID:15522813 is_a: NCBITaxon:1437010 ! Boreoeutheria [Term] id: NCBITaxon:314147 name: Glires namespace: ncbi_taxonomy synonym: "Rodents and rabbits" EXACT genbank_common_name [] xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:15522813 is_a: NCBITaxon:314146 ! Euarchontoglires disjoint_from: NCBITaxon:9443 ! Primates [Term] id: NCBITaxon:314293 name: Simiiformes namespace: ncbi_taxonomy synonym: "Anthropoidea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:376913 ! Haplorrhini [Term] id: NCBITaxon:314295 name: Hominoidea namespace: ncbi_taxonomy synonym: "ape" EXACT OMO:0003003 [] synonym: "apes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9526 ! Catarrhini [Term] id: NCBITaxon:32341 name: Sophophora namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7215 ! Drosophila [Term] id: NCBITaxon:32346 name: melanogaster group namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32341 ! Sophophora [Term] id: NCBITaxon:32351 name: melanogaster subgroup namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32346 ! melanogaster group [Term] id: NCBITaxon:32440 name: Chondrostei namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri disjoint_from: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32443 name: Teleostei namespace: ncbi_taxonomy synonym: "teleost fishes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32519 name: Ostariophysi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:186634 ! Otomorpha [Term] id: NCBITaxon:32523 name: Tetrapoda namespace: ncbi_taxonomy synonym: "tetrapods" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha disjoint_from: NCBITaxon:7878 ! Dipnomorpha [Term] id: NCBITaxon:32524 name: Amniota namespace: ncbi_taxonomy synonym: "amniotes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda disjoint_from: NCBITaxon:8292 ! Amphibia [Term] id: NCBITaxon:32525 name: Theria namespace: ncbi_taxonomy synonym: "Theria" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia disjoint_from: NCBITaxon:9254 ! Prototheria [Term] id: NCBITaxon:32561 name: Sauria namespace: ncbi_taxonomy synonym: "Diapsida" RELATED synonym [] synonym: "diapsids" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:33090 name: Viridiplantae namespace: ncbi_taxonomy synonym: "Chlorobionta" RELATED synonym [] synonym: "Chlorophyta/Embryophyta group" EXACT equivalent_name [] synonym: "chlorophyte/embryophyte group" EXACT equivalent_name [] synonym: "Chloroplastida" RELATED synonym [] synonym: "green plants" EXACT OMO:0003003 [] synonym: "green plants" RELATED blast_name [] xref: GC_ID:1 xref: PMID:16248873 xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota disjoint_from: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:33154 name: Opisthokonta namespace: ncbi_taxonomy synonym: "Fungi/Metazoa group" RELATED synonym [] synonym: "opisthokonts" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:33208 name: Metazoa namespace: ncbi_taxonomy synonym: "Animalia" RELATED synonym [] synonym: "animals" RELATED blast_name [] synonym: "metazoans" EXACT genbank_common_name [] synonym: "multicellular animals" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:33154 ! Opisthokonta disjoint_from: NCBITaxon:4751 ! Fungi [Term] id: NCBITaxon:33213 name: Bilateria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa disjoint_from: NCBITaxon:6073 ! Cnidaria [Term] id: NCBITaxon:33317 name: Protostomia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria disjoint_from: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:33340 name: Neoptera namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7496 ! Pterygota [Term] id: NCBITaxon:33392 name: Endopterygota namespace: ncbi_taxonomy synonym: "Holometabola" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:33340 ! Neoptera [Term] id: NCBITaxon:33511 name: Deuterostomia namespace: ncbi_taxonomy synonym: "deuterostomes" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:337687 name: Muroidea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15019624 xref: PMID:15371245 is_a: NCBITaxon:1963758 ! Myomorpha [Term] id: NCBITaxon:376913 name: Haplorrhini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:9443 ! Primates [Term] id: NCBITaxon:39107 name: Murinae namespace: ncbi_taxonomy alt_id: NCBITaxon:109679 xref: GC_ID:1 is_a: NCBITaxon:10066 ! Muridae [Term] id: NCBITaxon:40674 name: Mammalia namespace: ncbi_taxonomy synonym: "mammals" EXACT genbank_common_name [] synonym: "mammals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota disjoint_from: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:41324 name: Siboglinidae namespace: ncbi_taxonomy alt_id: NCBITaxon:167797 alt_id: NCBITaxon:27906 alt_id: NCBITaxon:29174 alt_id: NCBITaxon:41329 alt_id: NCBITaxon:54122 alt_id: NCBITaxon:55674 alt_id: NCBITaxon:55678 alt_id: NCBITaxon:6422 synonym: "Frenulata" RELATED synonym [] synonym: "Lamellibrachiidae" RELATED synonym [] synonym: "Obturata" RELATED synonym [] synonym: "Oligobrachiidae" RELATED synonym [] synonym: "Perviata" RELATED synonym [] synonym: "Pogonophora" RELATED synonym [] synonym: "pogonophores" EXACT OMO:0003003 [] synonym: "Polybrachiidae" RELATED synonym [] synonym: "Sclerolinidae" RELATED synonym [] synonym: "tube worms" RELATED blast_name [] synonym: "Vestimentifera" RELATED synonym [] synonym: "vestimentiferans" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6362 ! Sabellida [Term] id: NCBITaxon:41665 name: Neopterygii namespace: ncbi_taxonomy synonym: "Neopterygi" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:41666 name: Batrachia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8292 ! Amphibia [Term] id: NCBITaxon:436486 name: Dinosauria namespace: ncbi_taxonomy synonym: "dinosaur" EXACT OMO:0003003 [] synonym: "dinosaurs" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:436489 name: Saurischia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436486 ! Dinosauria [Term] id: NCBITaxon:436491 name: Theropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436489 ! Saurischia [Term] id: NCBITaxon:436492 name: Coelurosauria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436491 ! Theropoda [Term] id: NCBITaxon:43733 name: Muscomorpha namespace: ncbi_taxonomy alt_id: NCBITaxon:43732 synonym: "Asilomorpha" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:7203 ! Brachycera [Term] id: NCBITaxon:43738 name: Schizophora namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:480117 ! Cyclorrhapha [Term] id: NCBITaxon:43741 name: Acalyptratae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:43738 ! Schizophora [Term] id: NCBITaxon:43746 name: Ephydroidea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:43741 ! Acalyptratae [Term] id: NCBITaxon:43845 name: Drosophilinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7214 ! Drosophilidae [Term] id: NCBITaxon:46877 name: Drosophilini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:43845 ! Drosophilinae [Term] id: NCBITaxon:4751 name: Fungi namespace: ncbi_taxonomy synonym: "fungi" RELATED blast_name [] synonym: "Mycota" RELATED synonym [] xref: GC_ID:1 xref: PMID:11062127 xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:480117 name: Cyclorrhapha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:480118 ! Eremoneura [Term] id: NCBITaxon:480118 name: Eremoneura namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:43733 ! Muscomorpha [Term] id: NCBITaxon:50557 name: Insecta namespace: ncbi_taxonomy synonym: "insects" EXACT genbank_common_name [] synonym: "insects" RELATED blast_name [] synonym: "true insects" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:55879 name: Rhabditoidea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2301119 ! Rhabditomorpha [Term] id: NCBITaxon:55885 name: Peloderinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6243 ! Rhabditidae [Term] id: NCBITaxon:6040 name: Porifera namespace: ncbi_taxonomy synonym: "Parazoa" RELATED synonym [] synonym: "sponges" EXACT genbank_common_name [] synonym: "sponges" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa disjoint_from: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:6072 name: Eumetazoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6073 name: Cnidaria namespace: ncbi_taxonomy synonym: "cnidarians" EXACT genbank_common_name [] synonym: "cnidarians" RELATED blast_name [] synonym: "Coelenterata" RELATED in_part [] synonym: "coelenterates" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:6157 name: Platyhelminthes namespace: ncbi_taxonomy synonym: "flatworm" EXACT OMO:0003003 [] synonym: "flatworms" EXACT genbank_common_name [] synonym: "flatworms" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:1206795 ! Lophotrochozoa disjoint_from: NCBITaxon:6340 ! Annelida [Term] id: NCBITaxon:6231 name: Nematoda namespace: ncbi_taxonomy synonym: "Nemata" RELATED synonym [] synonym: "nematode" EXACT OMO:0003003 [] synonym: "nematodes" EXACT OMO:0003003 [] synonym: "nematodes" RELATED blast_name [] synonym: "roundworm" EXACT OMO:0003003 [] synonym: "roundworms" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa disjoint_from: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6236 name: Rhabditida namespace: ncbi_taxonomy alt_id: NCBITaxon:33251 alt_id: NCBITaxon:6308 synonym: "Strongylida" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:119089 ! Chromadorea [Term] id: NCBITaxon:6237 name: Caenorhabditis namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:55885 ! Peloderinae [Term] id: NCBITaxon:6239 name: Caenorhabditis elegans namespace: ncbi_taxonomy synonym: "Rhabditis elegans" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:6237 ! Caenorhabditis [Term] id: NCBITaxon:6243 name: Rhabditidae namespace: ncbi_taxonomy alt_id: NCBITaxon:54603 xref: GC_ID:1 is_a: NCBITaxon:55879 ! Rhabditoidea [Term] id: NCBITaxon:6340 name: Annelida namespace: ncbi_taxonomy synonym: "annelid worms" EXACT genbank_common_name [] synonym: "segmented worms" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:1206795 ! Lophotrochozoa [Term] id: NCBITaxon:6341 name: Polychaeta namespace: ncbi_taxonomy synonym: "polychaetes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:6340 ! Annelida [Term] id: NCBITaxon:6362 name: Sabellida namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:105391 ! Canalipalpata [Term] id: NCBITaxon:6656 name: Arthropoda namespace: ncbi_taxonomy synonym: "arthropods" EXACT genbank_common_name [] synonym: "arthropods" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6960 name: Hexapoda namespace: ncbi_taxonomy synonym: "Atelocerata" RELATED in_part [] synonym: "hexapods" EXACT genbank_common_name [] synonym: "hexapods" RELATED blast_name [] synonym: "Tracheata" RELATED in_part [] synonym: "Uniramia" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:7147 name: Diptera namespace: ncbi_taxonomy synonym: "flies" EXACT genbank_common_name [] synonym: "flies" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33392 ! Endopterygota [Term] id: NCBITaxon:7203 name: Brachycera namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7147 ! Diptera [Term] id: NCBITaxon:7214 name: Drosophilidae namespace: ncbi_taxonomy synonym: "pomace flies" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:43746 ! Ephydroidea [Term] id: NCBITaxon:7215 name: Drosophila namespace: ncbi_taxonomy alt_id: NCBITaxon:7326 synonym: "Drosophila" EXACT scientific_name [] synonym: "fruit flies" EXACT genbank_common_name [] synonym: "fruit fly" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:46877 ! Drosophilini [Term] id: NCBITaxon:7227 name: Drosophila melanogaster namespace: ncbi_taxonomy alt_id: NCBITaxon:2267365 synonym: "fruit fly" EXACT genbank_common_name [] synonym: "Sophophora melanogaster" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:32351 ! melanogaster subgroup [Term] id: NCBITaxon:7496 name: Pterygota namespace: ncbi_taxonomy synonym: "Pterygota" EXACT scientific_name [] synonym: "winged insects" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:85512 ! Dicondylia [Term] id: NCBITaxon:7711 name: Chordata namespace: ncbi_taxonomy synonym: "chordates" EXACT genbank_common_name [] synonym: "chordates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:7712 name: Tunicata namespace: ncbi_taxonomy synonym: "tunicates" EXACT genbank_common_name [] synonym: "tunicates" RELATED blast_name [] synonym: "Urochordata" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata disjoint_from: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7742 name: Vertebrata namespace: ncbi_taxonomy synonym: "Vertebrata" EXACT scientific_name [] synonym: "vertebrates" EXACT genbank_common_name [] synonym: "vertebrates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7761 name: Myxiniformes namespace: ncbi_taxonomy synonym: "hagfishes" RELATED blast_name [] synonym: "Myxinoidea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:117565 ! Myxini [Term] id: NCBITaxon:7762 name: Myxinidae namespace: ncbi_taxonomy synonym: "hagfishes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7761 ! Myxiniformes [Term] id: NCBITaxon:7776 name: Gnathostomata namespace: ncbi_taxonomy synonym: "Gnathostomata" EXACT scientific_name [] synonym: "jawed vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:7777 name: Chondrichthyes namespace: ncbi_taxonomy synonym: "cartilaginous fishes" EXACT genbank_common_name [] synonym: "cartilaginous fishes" RELATED blast_name [] synonym: "fish" EXACT OMO:0003003 [] synonym: "fishes" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:7863 name: Holocephali namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7777 ! Chondrichthyes [Term] id: NCBITaxon:7864 name: Chimaeriformes namespace: ncbi_taxonomy synonym: "chimaeras" EXACT genbank_common_name [] synonym: "chimaeras" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:7863 ! Holocephali [Term] id: NCBITaxon:7878 name: Dipnomorpha namespace: ncbi_taxonomy synonym: "Choanichthyes" RELATED in_part [] synonym: "Dipneusti" RELATED synonym [] synonym: "dipnoans" EXACT OMO:0003003 [] synonym: "Dipnoi" RELATED synonym [] synonym: "fish" EXACT OMO:0003003 [] synonym: "fishes" EXACT OMO:0003003 [] synonym: "lungfishes" EXACT genbank_common_name [] synonym: "lungfishes" RELATED blast_name [] synonym: "Osteichthyes" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:7898 name: Actinopterygii namespace: ncbi_taxonomy synonym: "Actinopterygi" RELATED synonym [] synonym: "bony fishes" RELATED blast_name [] synonym: "fish" EXACT OMO:0003003 [] synonym: "fishes" EXACT OMO:0003003 [] synonym: "Osteichthyes" RELATED in_part [] synonym: "ray-finned fishes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi disjoint_from: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:7899 name: Acipenseriformes namespace: ncbi_taxonomy synonym: "sturgeons and paddlefish" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32440 ! Chondrostei [Term] id: NCBITaxon:7900 name: Acipenseridae namespace: ncbi_taxonomy synonym: "sturgeons" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:186622 ! Acipenseroidei [Term] id: NCBITaxon:7901 name: Acipenser namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:124130 ! Acipenserini [Term] id: NCBITaxon:7952 name: Cypriniformes namespace: ncbi_taxonomy synonym: "carps and others" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:186627 ! Cypriniphysae [Term] id: NCBITaxon:7954 name: Danio namespace: ncbi_taxonomy alt_id: NCBITaxon:46777 alt_id: NCBITaxon:487617 synonym: "Brachydanio" RELATED synonym [] synonym: "Celestichthys" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2743711 ! Danioninae [Term] id: NCBITaxon:7955 name: Danio rerio namespace: ncbi_taxonomy alt_id: NCBITaxon:27702 alt_id: NCBITaxon:37966 synonym: "Brachydanio rerio" RELATED synonym [] synonym: "Brachydanio rerio frankei" RELATED synonym [] synonym: "Cyprinus rerio" RELATED synonym [] synonym: "Danio frankei" RELATED synonym [] synonym: "Danio rerio frankei" RELATED synonym [] synonym: "leopard danio" EXACT OMO:0003003 [] synonym: "zebra danio" EXACT OMO:0003003 [] synonym: "zebra fish" EXACT OMO:0003003 [] synonym: "zebrafish" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7954 ! Danio [Term] id: NCBITaxon:8287 name: Sarcopterygii namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8292 name: Amphibia namespace: ncbi_taxonomy synonym: "amphibians" EXACT genbank_common_name [] synonym: "amphibians" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:8342 name: Anura namespace: ncbi_taxonomy synonym: "anurans" EXACT OMO:0003003 [] synonym: "frogs" EXACT OMO:0003003 [] synonym: "frogs & toads" RELATED blast_name [] synonym: "frogs and toads" EXACT genbank_common_name [] synonym: "Salientia" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:41666 ! Batrachia [Term] id: NCBITaxon:8352 name: Pipidae namespace: ncbi_taxonomy synonym: "pipid frogs" EXACT OMO:0003003 [] synonym: "tongueless frogs" EXACT genbank_common_name [] xref: GC_ID:1 xref: PMID:2385174 is_a: NCBITaxon:30319 ! Pipoidea [Term] id: NCBITaxon:8353 name: Xenopus namespace: ncbi_taxonomy synonym: "Xenopus" EXACT scientific_name [] xref: GC_ID:1 xref: PMID:2385174 is_a: NCBITaxon:8360 ! Xenopodinae [Term] id: NCBITaxon:8355 name: Xenopus laevis namespace: ncbi_taxonomy synonym: "African clawed frog" EXACT genbank_common_name [] synonym: "Bufo laevis" RELATED synonym [] synonym: "clawed frog" EXACT OMO:0003003 [] synonym: "common platanna" EXACT OMO:0003003 [] synonym: "platanna" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:262014 ! Xenopus [Term] id: NCBITaxon:8360 name: Xenopodinae namespace: ncbi_taxonomy synonym: "Siluraninae" RELATED synonym [] xref: GC_ID:1 xref: PMID:2385174 is_a: NCBITaxon:8352 ! Pipidae [Term] id: NCBITaxon:8457 name: Sauropsida namespace: ncbi_taxonomy synonym: "sauropsids" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:8492 name: Archosauria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1329799 ! Archelosauria [Term] id: NCBITaxon:8504 name: Lepidosauria namespace: ncbi_taxonomy synonym: "lepidosaurs" EXACT genbank_common_name [] synonym: "lizards & snakes" RELATED blast_name [] synonym: "reptiles" RELATED in_part [] synonym: "Reptilia" RELATED in_part [] xref: GC_ID:1 xref: PMID:22982760 is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:8505 name: Sphenodontia namespace: ncbi_taxonomy synonym: "beaked reptiles" EXACT genbank_common_name [] synonym: "Rhynchocephalia" RELATED synonym [] synonym: "rhynchocephalians" EXACT OMO:0003003 [] synonym: "Rhynchosauria" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:8504 ! Lepidosauria [Term] id: NCBITaxon:8506 name: Sphenodontidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8505 ! Sphenodontia [Term] id: NCBITaxon:8507 name: Sphenodon namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8506 ! Sphenodontidae [Term] id: NCBITaxon:85512 name: Dicondylia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:50557 ! Insecta [Term] id: NCBITaxon:862507 name: Mus namespace: ncbi_taxonomy synonym: "Mus" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:10088 ! Mus [Term] id: NCBITaxon:8782 name: Aves namespace: ncbi_taxonomy synonym: "avian" RELATED synonym [] synonym: "birds" EXACT genbank_common_name [] synonym: "birds" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:436492 ! Coelurosauria [Term] id: NCBITaxon:8783 name: Palaeognathae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8782 ! Aves disjoint_from: NCBITaxon:8825 ! Neognathae [Term] id: NCBITaxon:8798 name: Struthioniformes namespace: ncbi_taxonomy synonym: "ostriches" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:8783 ! Palaeognathae [Term] id: NCBITaxon:8799 name: Struthionidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8798 ! Struthioniformes [Term] id: NCBITaxon:8800 name: Struthio namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8799 ! Struthionidae [Term] id: NCBITaxon:8801 name: Struthio camelus namespace: ncbi_taxonomy synonym: "African ostrich" EXACT genbank_common_name [] synonym: "ostrich" EXACT OMO:0003003 [] synonym: "Struthio camelus domesticus" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:8800 ! Struthio [Term] id: NCBITaxon:8825 name: Neognathae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8782 ! Aves [Term] id: NCBITaxon:88770 name: Panarthropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:8929 name: Columbiformes namespace: ncbi_taxonomy synonym: "pigeons and others" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:3073799 ! Columbimorphae [Term] id: NCBITaxon:8930 name: Columbidae namespace: ncbi_taxonomy synonym: "pigeons" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:8929 ! Columbiformes [Term] id: NCBITaxon:89593 name: Craniata namespace: ncbi_taxonomy synonym: "Craniata" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:9254 name: Prototheria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:9255 name: Monotremata namespace: ncbi_taxonomy synonym: "egg-laying mammals" EXACT genbank_common_name [] synonym: "monotremes" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:9254 ! Prototheria [Term] id: NCBITaxon:9259 name: Tachyglossidae namespace: ncbi_taxonomy synonym: "echidnas" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9255 ! Monotremata [Term] id: NCBITaxon:9347 name: Eutheria namespace: ncbi_taxonomy synonym: "eutherian mammals" EXACT OMO:0003003 [] synonym: "placental mammals" EXACT OMO:0003003 [] synonym: "Placentalia" RELATED synonym [] synonym: "placentals" EXACT genbank_common_name [] synonym: "placentals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32525 ! Theria [Term] id: NCBITaxon:9443 name: Primates namespace: ncbi_taxonomy synonym: "Primata" RELATED synonym [] synonym: "primate" EXACT equivalent_name [] synonym: "primates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314146 ! Euarchontoglires [Term] id: NCBITaxon:9526 name: Catarrhini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:314293 ! Simiiformes [Term] id: NCBITaxon:9604 name: Hominidae namespace: ncbi_taxonomy synonym: "great apes" EXACT genbank_common_name [] synonym: "Pongidae" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:314295 ! Hominoidea [Term] id: NCBITaxon:9605 name: Homo namespace: ncbi_taxonomy synonym: "humans" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:207598 ! Homininae [Term] id: NCBITaxon:9606 name: Homo sapiens namespace: ncbi_taxonomy synonym: "human" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9605 ! Homo [Term] id: NCBITaxon:9989 name: Rodentia namespace: ncbi_taxonomy synonym: "rodent" EXACT genbank_common_name [] synonym: "rodents" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires [Term] id: PATO:0000001 name: quality namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 ! specifically dependent continuant [Term] id: PATO:0000025 name: composition namespace: quality alt_id: PATO:0002015 def: "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." [PATOC:GVG] comment: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). subset: attribute_slim subset: scalar_slim synonym: "composed of" EXACT [] synonym: "compositionality" EXACT [] synonym: "content" EXACT [] synonym: "structure, composition" EXACT [] is_a: PATO:0000141 ! structure [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape namespace: quality alt_id: PATO:0001647 def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000136 name: closure namespace: quality def: "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." [PATOC:CJM, PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000141 name: structure namespace: quality alt_id: PATO:0001452 def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG] subset: attribute_slim synonym: "conformation" BROAD [VT:1000738] synonym: "relational structural quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000150 name: texture namespace: quality def: "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000261 name: maturity namespace: quality def: "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." [Merriam-Webster:Merriam-Webster] subset: attribute_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000402 name: branched namespace: quality def: "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ramified" EXACT [] synonym: "ramiform" EXACT [] is_a: PATO:0002009 ! branchiness [Term] id: PATO:0000407 name: flat namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." [web:http\://www.merriam-webster.com/] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "plate-like" RELATED [] is_a: PATO:0002254 ! flattened [Term] id: PATO:0000411 name: circular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "round" RELATED [] synonym: "rounded" RELATED [] is_a: PATO:0000947 ! elliptic [Term] id: PATO:0000608 name: closed namespace: quality def: "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." [answers.com:answers.com] subset: value_slim synonym: "blocked" RELATED [] is_a: PATO:0000136 ! closure [Term] id: PATO:0000947 name: elliptic namespace: quality def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ellipse-shaped" EXACT [] synonym: "ellipsoid" EXACT [] synonym: "elliptical" EXACT [] synonym: "oval" RELATED [] synonym: "ovoid" RELATED [] is_a: PATO:0002318 ! superelliptic [Term] id: PATO:0000957 name: opacity namespace: quality def: "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001300 ! optical quality [Term] id: PATO:0000963 name: opaque namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clouding" RELATED [] synonym: "cloudy" RELATED [] synonym: "non-transparent" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0000964 name: transparent namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clear" EXACT [] synonym: "hyaline" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0000992 name: viscosity namespace: quality def: "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001548 ! quality of a liquid [Term] id: PATO:0000998 name: viscous namespace: quality def: "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0000992 ! viscosity [Term] id: PATO:0001018 name: physical quality namespace: quality alt_id: PATO:0002079 def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG] subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001031 name: elasticity namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001171 name: elastic namespace: quality def: "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0001031 ! elasticity [Term] id: PATO:0001185 name: larval namespace: quality def: "A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis." [Wikipedia:http\://en.wikipedia.org/wiki/Larval] subset: value_slim is_a: PATO:0000261 ! maturity [Term] id: PATO:0001241 name: physical object quality namespace: quality alt_id: PATO:0001237 alt_id: PATO:0001238 def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity" EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001300 name: optical quality namespace: quality def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation [Term] id: PATO:0001374 name: ploidy namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." [Wikipedia:http\://en.wikipedia.org/wiki/Ploidy] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001375 name: haploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Haploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001377 name: polyploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Polyploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001393 name: euploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Euploid] subset: cell_quality subset: value_slim is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0001397 name: cellular potency namespace: quality def: "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001400 name: unipotent namespace: quality def: "A cellular potency that is the capacity to produce only one differentiated cell type." [Wikipedia:http\://en.wikipedia.org/wiki/Unipotent] comment: Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001401 name: oligopotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." [PATOC:MAH] comment: Less potent than multipotent, often thought of as precursor or progenitor cell status. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001402 name: multipotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types." [Wikipedia:http\://en.wikipedia.org/wiki/Multipotent] subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001410 name: striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001546 name: quality of a solid namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/soliddefinition.htm] subset: attribute_slim synonym: "solidity" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001547 name: quality of a gas namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm, PATOC:GVG] subset: attribute_slim synonym: "gaseous" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001548 name: quality of a liquid namespace: quality def: "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." [url:http\://www.chemistry-dictionary.com/definition/liquid.php] subset: attribute_slim synonym: "liquidity" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001579 name: contractility namespace: quality def: "A physical quality that is the ability to contract or shrink." [WordNet:WordNet] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001591 name: curvature namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001690 name: contractile namespace: quality def: "A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted." [PATOC:GVG] comment: This refers to the disposition of the bearer. subset: disposition_slim subset: value_slim is_a: PATO:0001579 ! contractility [Term] id: PATO:0001735 name: liquid configuration namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids." [PATOC:GVG] synonym: "liquid" EXACT [] is_a: PATO:0001548 ! quality of a liquid [Term] id: PATO:0001736 name: solid configuration namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids." [PATOC:GVG] subset: value_slim synonym: "solid" EXACT [] is_a: PATO:0001546 ! quality of a solid [Term] id: PATO:0001748 name: invaginated namespace: quality def: "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0001857 name: concave namespace: quality def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity [Term] id: PATO:0001873 name: cylindrical namespace: quality alt_id: PATO:0001203 def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." [PATOC:MAH] subset: cell_quality subset: value_slim synonym: "rod-like" EXACT [] synonym: "rod-shaped" EXACT [] synonym: "tubulate" NARROW [] is_a: PATO:0002007 ! convex 3-D shape relationship: RO:0015011 PATO:0000411 ! has cross section circular [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001987 name: saccular namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." [PATOC:MAH] subset: value_slim synonym: "sacular" EXACT [] is_a: PATO:0002014 ! structure, cavities [Term] id: PATO:0001992 name: cellularity namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0001993 name: multicellular namespace: quality def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." [PATOC:GVG] subset: value_slim is_a: PATO:0001992 ! cellularity [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002005 name: concavity namespace: quality def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0002006 name: 2-D shape namespace: quality def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM] subset: attribute_slim synonym: "2-D projection" RELATED [] synonym: "cross-sectional" RELATED [] is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape namespace: quality def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM] comment: Use this term or an is_a child of this term when the entire shape of the object is known. subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: RO:0015011 PATO:0002006 ! has cross section 2-D shape [Term] id: PATO:0002009 name: branchiness namespace: quality def: "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." [PATOC:MAH] subset: attribute_slim subset: cell_quality is_a: PATO:0000052 ! shape [Term] id: PATO:0002014 name: structure, cavities namespace: quality def: "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0002039 name: biconcave namespace: quality def: "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." [PATOC:GVG] subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0002045 name: dendritic namespace: quality def: "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." [PATOC:cvs] subset: value_slim synonym: "dendriform" EXACT [] synonym: "dendroid" EXACT [] synonym: "dendroidal" EXACT [] is_a: PATO:0000402 ! branched property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-02-15T08:11:41Z [Term] id: PATO:0002064 name: fenestrated namespace: quality def: "A structure quality inhering in a bearer by virtue of the bearer's delimited by a surface with holes." [PATOC:me] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-07-01T01:46:53Z [Term] id: PATO:0002078 name: hollow namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." [url:http\://www.merriam-webster.com/dictionary/hollow] subset: value_slim is_a: PATO:0002014 ! structure, cavities property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-09-18T02:19:20Z [Term] id: PATO:0002094 name: basophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0070045 ! anatomical histological quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-05T12:05:23Z [Term] id: PATO:0002124 name: laminar namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-06T04:37:14Z [Term] id: PATO:0002198 name: quality of a substance namespace: quality def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001018 ! physical quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-15T04:35:27Z [Term] id: PATO:0002226 name: subcylindrical namespace: quality def: "A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical." [url:http\://www.thefreedictionary.com/Subcylindrical] subset: value_slim is_a: PATO:0001873 ! cylindrical property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-07-13T04:22:30Z [Term] id: PATO:0002254 name: flattened namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." [PATOC:CVS] comment: Becoming flat but not necessarily completely flat. subset: value_slim synonym: "compressed" RELATED [] is_a: PATO:0001591 ! curvature property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-08-16T03:59:34Z [Term] id: PATO:0002255 name: grooved namespace: quality def: "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." [PATOC:JE] subset: value_slim synonym: "channeled" RELATED [] synonym: "creased" RELATED [] is_a: PATO:0000150 ! texture property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-01T10:27:48Z [Term] id: PATO:0002266 name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-10-05T12:31:16Z [Term] id: PATO:0002299 name: tubular namespace: quality def: "A cylindrical shape that is hollow." [PATOC:GVG] synonym: "tube like" EXACT [] synonym: "tube-shaped" EXACT [] synonym: "tubulate" EXACT [] is_a: PATO:0001873 ! cylindrical is_a: PATO:0002078 ! hollow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-08T06:33:50Z [Term] id: PATO:0002309 name: fiber shaped namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter." [PATOC:DC] comment: Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope). subset: value_slim is_a: PATO:0002226 ! subcylindrical property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-09-09T04:50:10Z [Term] id: PATO:0002318 name: superelliptic namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-10-12T12:45:16Z [Term] id: PATO:0002418 name: acidophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." [PATOC:GVG] comment: Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic. subset: mpath_slim subset: value_slim synonym: "eosinophilic" EXACT [] is_a: PATO:0070045 ! anatomical histological quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:01:19Z [Term] id: PATO:0002422 name: acinar namespace: quality def: "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." [wikipedia:https\://en.wikipedia.org/wiki/Acinus] comment: Acinus is Latin for berry. subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:11:10Z [Term] id: PATO:0002462 name: collagenous namespace: quality def: "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." [PATOC:WD] subset: value_slim is_a: PATO:0000025 ! composition property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T11:34:15Z [Term] id: PATO:0002468 name: distensible namespace: quality def: "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." [PATOC:WD] subset: value_slim is_a: PATO:0015008 ! distensibility property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T11:48:26Z [Term] id: PATO:0002478 name: transversely striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." [PATOC:DS] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001410 ! striated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T12:29:15Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-21T05:44:34Z [Term] id: PATO:0010001 name: disconnected namespace: quality def: "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." [GOC:dos] is_a: PATO:0000141 ! structure property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2014-12-12T08:43:17Z [Term] id: PATO:0015006 name: polymeric namespace: quality def: "A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array." [GOC:DOS, https://github.com/pato-ontology/pato/issues/78] comment: A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline. subset: value_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0015008 name: distensibility namespace: quality def: "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." [GOC:CJM] subset: attribute_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0040072 name: high nuclear/cytoplasmic ratio namespace: quality def: "A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio." [http://lymerick.net/blood-cells.pdf, Wikipedia:NC_ratio&oldid=931936284] comment: A high nuclear/cytolasmic ratio is 70% or higher. synonym: "high N:C ratio" EXACT [] is_a: PATO:0001396 ! cellular quality created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: PATO:0070044 name: anatomical structure quality namespace: quality def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." [] is_a: PATO:0001241 ! physical object quality created_by: http://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070045 name: anatomical histological quality namespace: quality def: "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." [] is_a: PATO:0070044 ! anatomical structure quality created_by: http://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070047 name: polychromatophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." [GOC:add] is_a: PATO:0070045 ! anatomical histological quality created_by: http://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070060 name: quality of interaction of a substance with electromagnetic radiation namespace: quality def: "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." [https://orcid.org/0000-0002-5111-7263] subset: attribute_slim is_a: PATO:0002198 ! quality of a substance [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB] comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB). synonym: "native protein" NARROW [IEDB:BP] synonym: "natural protein" EXACT [PRO:DAN] is_a: PR:000018263 ! amino acid chain is_a: PR:000064867 ! protein-containing molecular entity intersection_of: PR:000018263 ! amino acid chain intersection_of: has_gene_template SO:0000704 intersection_of: output_of GO:0006412 ! translation relationship: has_gene_template SO:0000704 relationship: output_of GO:0006412 ! translation [Term] id: PR:000001002 name: CD19 molecule namespace: protein def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte surface antigen B4" EXACT [] synonym: "CD19" EXACT PRO-short-label [PRO:DNx] synonym: "differentiation antigen CD19" EXACT [] synonym: "T-cell surface antigen Leu-12" EXACT [] xref: IUPHARobj:2764 xref: PIRSF:PIRSF016630 is_a: PR:000000001 ! protein [Term] id: PR:000001003 name: CD34 molecule namespace: protein def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [PMID:16720896, PMID:8983065] comment: Category=gene. Requested by=CL. synonym: "CD34" EXACT PRO-short-label [PRO:DNx] synonym: "hematopoietic progenitor cell antigen CD34" EXACT [] xref: PIRSF:PIRSF028749 is_a: PR:000000001 ! protein [Term] id: PR:000001004 name: CD4 molecule namespace: protein def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [PMID:15326605] comment: Category=gene. Requested by=CL. synonym: "CD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] xref: PIRSF:PIRSF001977 is_a: PR:000000001 ! protein [Term] id: PR:000001005 name: integrin alpha with A domain namespace: protein def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." [PIRSF:PIRSF002497] comment: Category=family. synonym: "integrin alpha with I domain" EXACT [] xref: PIRSF:PIRSF002497 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000001012 name: integrin alpha-M namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [UniProtKB:P11215] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member B" EXACT [] synonym: "CD11B" RELATED Gene-based [] synonym: "CD11b" EXACT [] synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT [] synonym: "CR-3 alpha chain" EXACT [] synonym: "CR3A" RELATED Gene-based [] synonym: "ITGAM" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte adhesion receptor MO1" EXACT [] synonym: "neutrophil adherence receptor" EXACT [] xref: IUPHARobj:2452 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001018 name: CD3 subunit with immunoglobulin domain namespace: protein def: "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736] comment: Category=family. synonym: "CD3 subunit with Ig-like domain" EXACT [] xref: PIRSF:PIRSF001993 is_a: PR:000000001 ! protein [Term] id: PR:000001020 name: CD3 epsilon namespace: protein def: "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD3E" EXACT PRO-short-label [PRO:DNx] synonym: "CD3e" EXACT [] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT [] synonym: "T3E" RELATED Gene-based [] xref: IUPHARobj:2742 is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain [Term] id: PR:000001022 name: neural cell adhesion molecule namespace: protein def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF002507 is_a: PR:000000001 ! protein [Term] id: PR:000001023 name: neural cell adhesion molecule NCAM namespace: protein def: "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." [PMID:17975827] comment: Category=family. xref: PIRSF:PIRSF501037 is_a: PR:000001022 ! neural cell adhesion molecule [Term] id: PR:000001024 name: neural cell adhesion molecule 1 namespace: protein def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD56" EXACT [] synonym: "N-CAM-1" EXACT [] synonym: "NCAM" RELATED Gene-based [] synonym: "NCAM-1" EXACT [] synonym: "NCAM1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2769 is_a: PR:000001023 ! neural cell adhesion molecule NCAM [Term] id: PR:000001083 name: CD2 molecule namespace: protein def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD2" EXACT PRO-short-label [PRO:DNx] synonym: "erythrocyte receptor" EXACT [] synonym: "LFA-2" EXACT [] synonym: "LFA-3 receptor" EXACT [] synonym: "ly-37" EXACT [] synonym: "lymphocyte antigen 37" EXACT [] synonym: "rosette receptor" EXACT [] synonym: "SRBC" RELATED Gene-based [] synonym: "T-cell surface antigen CD2" EXACT [] synonym: "T-cell surface antigen T11/Leu-5" EXACT [] synonym: "T-cell surface glycoprotein CD2" EXACT [] xref: IUPHARobj:2600 xref: PIRSF:PIRSF001984 is_a: PR:000000001 ! protein [Term] id: PR:000001084 name: T-cell surface glycoprotein CD8 alpha chain namespace: protein def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8] comment: Category=gene. Requested by=CL. synonym: "CD8A" EXACT PRO-short-label [PRO:DNx] synonym: "CD8a" EXACT [] synonym: "Lyt-2" RELATED Gene-based [] synonym: "Lyt2" RELATED Gene-based [] synonym: "MAL" RELATED Gene-based [] synonym: "T-cell surface glycoprotein Lyt-2" EXACT [] synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001289 name: membrane-spanning 4-domains subfamily A member 1 namespace: protein def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen Ly-44" EXACT [] synonym: "B-cell surface antigen CD20" EXACT [] synonym: "B-lymphocyte antigen CD20" EXACT [] synonym: "B-lymphocyte surface antigen B1" EXACT [] synonym: "Bp35" EXACT [] synonym: "CD20" RELATED Gene-based [] synonym: "leukocyte surface antigen Leu-16" EXACT [] synonym: "Ly-44" RELATED Gene-based [] synonym: "lymphocyte antigen 44" EXACT [] synonym: "MS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "Ms4a2" RELATED Gene-based [] xref: IUPHARobj:2628 xref: PIRSF:PIRSF001995 is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin namespace: protein def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002504 is_a: PR:000000001 ! protein [Term] id: PR:000001444 name: cadherin-5 namespace: protein def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "7B4 antigen" EXACT [] synonym: "CD144" EXACT [] synonym: "CDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin" EXACT [] synonym: "VE-cadherin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001839 name: T-cell surface glycoprotein CD5 namespace: protein def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD5" EXACT PRO-short-label [PRO:DNx] synonym: "LEU1" RELATED Gene-based [] synonym: "ly-1" EXACT [] synonym: "lymphocyte antigen 1" EXACT [] synonym: "lymphocyte antigen T1/Leu-1" EXACT [] synonym: "Lyt-1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001869 name: interleukin-7 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD127" EXACT [] synonym: "CDw127" EXACT [] synonym: "IL-7 receptor subunit alpha" EXACT [] synonym: "IL-7R subunit alpha" EXACT [] synonym: "IL-7R-alpha" EXACT [] synonym: "IL-7RA" EXACT [] synonym: "IL7R" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1698 xref: PIRSF:PIRSF001960 is_a: PR:000000001 ! protein [Term] id: PR:000001889 name: CD14 molecule namespace: protein def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD14" EXACT PRO-short-label [PRO:DNx] synonym: "monocyte differentiation antigen CD14" EXACT [] synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT [] xref: PIRSF:PIRSF002017 is_a: PR:000000001 ! protein [Term] id: PR:000001945 name: transferrin receptor protein 1 namespace: protein def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD71" EXACT [] synonym: "p90" BROAD [PRO:DNx] synonym: "T9" EXACT [] synonym: "TfR" EXACT [] synonym: "TfR1" EXACT [] synonym: "TFRC" EXACT PRO-short-label [PRO:DNx] synonym: "TR" RELATED [] synonym: "Trfr" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038502 is_a: PR:000000001 ! protein [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED Gene-based [] synonym: "KDR" EXACT PRO-short-label [PRO:DNx] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] synonym: "VEGFR2" RELATED Gene-based [] xref: IUPHARobj:1813 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002976 name: Ly-6-like protein namespace: protein def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF002021 is_a: PR:000000001 ! protein [Term] id: PR:000002978 name: lymphocyte antigen 6G namespace: protein def: "An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "Ly-6G" EXACT [] synonym: "Ly-6G.1" EXACT [] synonym: "Ly6g" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002976 ! Ly-6-like protein [Term] id: PR:000002981 name: lymphocyte antigen 76 (mouse) namespace: protein def: "A protein that is a translation product of the Ly76 gene in mouse." [PMID:10848813, PRO:DAN] comment: Category=organism-gene. Requested by=CL. synonym: "mLy76" EXACT PRO-short-label [PRO:DNx] synonym: "ter-119" EXACT [] synonym: "ter119" EXACT [] is_a: PR:000029032 ! Mus musculus protein [Term] id: PR:000007499 name: fibroblast growth factor 8 namespace: protein def: "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "AIGF" RELATED Gene-based [] synonym: "androgen-induced growth factor" EXACT [] synonym: "FGF-8" EXACT [] synonym: "FGF8" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-8" RELATED [] synonym: "heparin-binding growth factor 8" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000009054 name: insulin gene translation product namespace: protein def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "INS" EXACT PRO-short-label [PRO:DNx] synonym: "insulin" BROAD [PRO:DAN] is_a: PR:000045358 ! insulin family protein [Term] id: PR:000014841 name: sonic hedgehog protein namespace: protein def: "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HHG-1" EXACT [] synonym: "Hhg1" RELATED Gene-based [] synonym: "SHH" EXACT PRO-short-label [PRO:DNx] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains" EXACT [] synonym: "ShhNC" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016043 name: T-cell acute lymphocytic leukemia protein 1 namespace: protein def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "BHLHA17" RELATED Gene-based [] synonym: "bHLHa17" EXACT [] synonym: "class A basic helix-loop-helix protein 17" EXACT [] synonym: "SCL" RELATED Gene-based [] synonym: "stem cell protein" EXACT [] synonym: "T-cell leukemia/lymphoma protein 5" EXACT [] synonym: "TAL-1" EXACT [] synonym: "TAL1" EXACT PRO-short-label [PRO:DNx] synonym: "TCL5" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [PRO:DAN, PRO:JSG] comment: Category=polymer. synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: CHEBI:50047 ! organic amino compound relationship: has_constituent_monomer CHEBI:33708 {minCardinality="2"} ! amino-acid residue [Term] id: PR:000025796 name: integrin alpha namespace: protein def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." [PMID:19693543] comment: Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. is_a: PR:000000001 ! protein [Term] id: PR:000029032 name: Mus musculus protein namespace: protein def: "A protein that is encoded in the genome of Mus musculus." [PRO:DAN] synonym: "mouse protein" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036194 ! eukaryotic protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus relationship: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:000029067 name: Homo sapiens protein namespace: protein def: "A protein that is encoded in the genome of Homo sapiens." [PRO:DAN] synonym: "human protein" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036194 ! eukaryotic protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens relationship: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000036194 name: eukaryotic protein namespace: protein def: "A protein that is encoded in the genome of some Eukaryota." [PRO:DAN] synonym: "Eukaryota protein" EXACT [PRO:DAN] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota relationship: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota [Term] id: PR:000045358 name: insulin family protein namespace: protein def: "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." [PRO:DAN] comment: Category=family. synonym: "fam:INS" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000064867 name: protein-containing molecular entity namespace: protein def: "A molecular entity that minimally consists of a protein." [PRO:DAN] comment: Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050565). synonym: "protein" NARROW [PRO:DAN] synonym: "protein aggregate" NARROW [PRO:DAN] synonym: "protein complex" NARROW [PRO:DAN] synonym: "protein-containing complex" NARROW [PRO:DAN] is_a: CHEBI:23367 ! molecular entity intersection_of: CHEBI:23367 ! molecular entity intersection_of: has_part PR:000000001 ! protein relationship: has_part PR:000000001 ! protein [Term] id: PR:P01308 name: insulin gene translation product (human) namespace: protein def: "An insulin gene translation product that is encoded in the genome of human." [PRO:DAN, UniProtKB:P01308] comment: Category=organism-gene. synonym: "hINS" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01308 is_a: PR:000009054 ! insulin gene translation product is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009054 ! insulin gene translation product intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01730 name: T-cell surface glycoprotein CD4 (human) namespace: protein def: "A CD4 molecule that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01730] comment: Category=organism-gene. synonym: "CD4" RELATED Gene-based [UniProtKB:P01730] synonym: "hCD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T4/Leu-3 (human)" EXACT [UniProtKB:P01730] xref: UniProtKB:P01730 is_a: PR:000001004 ! CD4 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001004 ! CD4 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01731 name: T-cell surface glycoprotein CD8 alpha chain (mouse) namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse." [OMA:P01731, PRO:DNx] comment: Category=organism-gene. synonym: "Cd8a" RELATED Gene-based [UniProtKB:P01731] synonym: "CD8a (mouse)" EXACT [UniProtKB:P01731] synonym: "Lyt-2" RELATED Gene-based [UniProtKB:P01731] synonym: "Lyt2" RELATED Gene-based [UniProtKB:P01731] synonym: "mCD8A" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein Lyt-2 (mouse)" EXACT [UniProtKB:P01731] xref: UniProtKB:P01731 is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01732 name: T-cell surface glycoprotein CD8 alpha chain (human) namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732] comment: Category=organism-gene. synonym: "CD8A" RELATED Gene-based [UniProtKB:P01732] synonym: "CD8a (human)" EXACT [UniProtKB:P01732] synonym: "hCD8A" EXACT PRO-short-label [PRO:DNx] synonym: "MAL" RELATED Gene-based [UniProtKB:P01732] synonym: "T-lymphocyte differentiation antigen T8/Leu-2 (human)" EXACT [UniProtKB:P01732] xref: UniProtKB:P01732 is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02786 name: transferrin receptor protein 1 (human) namespace: protein def: "A transferrin receptor protein 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P02786] comment: Category=organism-gene. synonym: "CD71 (human)" EXACT [UniProtKB:P02786] synonym: "hTFRC" EXACT PRO-short-label [PRO:DNx] synonym: "p90 (human)" BROAD [UniProtKB:P02786] synonym: "T9 (human)" EXACT [UniProtKB:P02786] synonym: "TfR (human)" EXACT [UniProtKB:P02786] synonym: "TfR1 (human)" EXACT [UniProtKB:P02786] synonym: "TFRC" RELATED Gene-based [UniProtKB:P02786] synonym: "TR (human)" BROAD [UniProtKB:P02786] synonym: "Trfr (human)" EXACT [UniProtKB:P02786] xref: Reactome:R-HSA-434196 "PR:P02786 located_in GO:0030659" xref: Reactome:R-HSA-434330 "PR:P02786 located_in GO:0000139" xref: Reactome:R-HSA-8869124 "PR:P02786 located_in GO:0030665" xref: Reactome:R-HSA-8961829 "PR:P02786 located_in GO:0010008" xref: Reactome:R-HSA-917983 "PR:P02786 located_in GO:0005886" xref: UniProtKB:P02786 is_a: PR:000001945 ! transferrin receptor protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05555 name: integrin alpha-M (mouse) namespace: protein def: "An integrin alpha-M that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P05555] comment: Category=organism-gene. synonym: "CD11 antigen-like family member B (mouse)" EXACT [UniProtKB:P05555] synonym: "CD11b (mouse)" EXACT [UniProtKB:P05555] synonym: "cell surface glycoprotein MAC-1 subunit alpha (mouse)" EXACT [UniProtKB:P05555] synonym: "CR-3 alpha chain (mouse)" EXACT [UniProtKB:P05555] synonym: "Itgam" RELATED Gene-based [UniProtKB:P05555] synonym: "leukocyte adhesion receptor MO1 (mouse)" EXACT [UniProtKB:P05555] synonym: "mITGAM" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P05555 is_a: PR:000001012 ! integrin alpha-M is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001012 ! integrin alpha-M intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06127 name: T-cell surface glycoprotein CD5 (human) namespace: protein def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P06127] comment: Category=organism-gene. synonym: "CD5" RELATED Gene-based [UniProtKB:P06127] synonym: "hCD5" EXACT PRO-short-label [PRO:DNx] synonym: "LEU1" RELATED Gene-based [UniProtKB:P06127] synonym: "lymphocyte antigen T1/Leu-1 (human)" EXACT [UniProtKB:P06127] xref: UniProtKB:P06127 is_a: PR:000001839 ! T-cell surface glycoprotein CD5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06332 name: T-cell surface glycoprotein CD4 (mouse) namespace: protein def: "A CD4 molecule that is encoded in the genome of mouse." [OMA:P06332, PRO:DNx] comment: Category=organism-gene. synonym: "Cd4" RELATED Gene-based [UniProtKB:P06332] synonym: "CD4 (mouse)" EXACT [UniProtKB:P06332] synonym: "mCD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell differentiation antigen L3T4 (mouse)" EXACT [UniProtKB:P06332] synonym: "T-cell surface antigen T4/Leu-3 (mouse)" EXACT [UniProtKB:P06332] xref: UniProtKB:P06332 is_a: PR:000001004 ! CD4 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001004 ! CD4 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06729 name: T-cell surface antigen CD2 (human) namespace: protein def: "A CD2 molecule that is encoded in the genome of human." [PRO:CNA, UniProtKB:P06729] comment: Category=organism-gene. synonym: "CD2" RELATED Gene-based [UniProtKB:P06729] synonym: "erythrocyte receptor (human)" EXACT [UniProtKB:P06729] synonym: "hCD2" EXACT PRO-short-label [PRO:DNx] synonym: "LFA-2 (human)" EXACT [UniProtKB:P06729] synonym: "LFA-3 receptor (human)" EXACT [UniProtKB:P06729] synonym: "rosette receptor (human)" EXACT [UniProtKB:P06729] synonym: "SRBC" RELATED Gene-based [UniProtKB:P06729] synonym: "T-cell surface antigen T11/Leu-5 (human)" EXACT [UniProtKB:P06729] xref: UniProtKB:P06729 is_a: PR:000001083 ! CD2 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001083 ! CD2 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07766 name: T-cell surface glycoprotein CD3 epsilon chain (human) namespace: protein def: "A CD3 epsilon that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07766] comment: Category=organism-gene. synonym: "CD3E" RELATED Gene-based [UniProtKB:P07766] synonym: "CD3e (human)" EXACT [UniProtKB:P07766] synonym: "hCD3E" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (human)" EXACT [UniProtKB:P07766] synonym: "T3E" RELATED Gene-based [UniProtKB:P07766] xref: UniProtKB:P07766 is_a: PR:000001020 ! CD3 epsilon is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001020 ! CD3 epsilon intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08571 name: monocyte differentiation antigen CD14 (human) namespace: protein def: "A CD14 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08571] comment: Category=organism-gene. synonym: "CD14" RELATED Gene-based [UniProtKB:P08571] synonym: "hCD14" EXACT PRO-short-label [PRO:DNx] synonym: "myeloid cell-specific leucine-rich glycoprotein (human)" EXACT [UniProtKB:P08571] xref: UniProtKB:P08571 is_a: PR:000001889 ! CD14 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001889 ! CD14 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08920 name: T-cell surface antigen CD2 (mouse) namespace: protein def: "A CD2 molecule that is encoded in the genome of mouse." [OMA:P08920, PRO:DNx] comment: Category=organism-gene. synonym: "Cd2" RELATED Gene-based [UniProtKB:P08920] synonym: "CD2 (mouse)" EXACT [UniProtKB:P08920] synonym: "LFA-2 (mouse)" EXACT [UniProtKB:P08920] synonym: "LFA-3 receptor (mouse)" EXACT [UniProtKB:P08920] synonym: "Ly-37" RELATED Gene-based [UniProtKB:P08920] synonym: "lymphocyte antigen 37 (mouse)" EXACT [UniProtKB:P08920] synonym: "mCD2" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T11/Leu-5 (mouse)" EXACT [UniProtKB:P08920] xref: UniProtKB:P08920 is_a: PR:000001083 ! CD2 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001083 ! CD2 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P10810 name: monocyte differentiation antigen CD14 (mouse) namespace: protein def: "A CD14 molecule that is encoded in the genome of mouse." [OMA:P10810, PRO:WCB] comment: Category=organism-gene. synonym: "Cd14" RELATED Gene-based [UniProtKB:P10810] synonym: "CD14 (mouse)" EXACT [UniProtKB:P10810] synonym: "mCD14" EXACT PRO-short-label [PRO:DNx] synonym: "myeloid cell-specific leucine-rich glycoprotein (mouse)" EXACT [UniProtKB:P10810] xref: UniProtKB:P10810 is_a: PR:000001889 ! CD14 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001889 ! CD14 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P11215 name: integrin alpha-M (human) namespace: protein def: "An integrin alpha-M that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11215] comment: Category=organism-gene. synonym: "CD11 antigen-like family member B (human)" EXACT [UniProtKB:P11215] synonym: "CD11B" RELATED Gene-based [UniProtKB:P11215] synonym: "cell surface glycoprotein MAC-1 subunit alpha (human)" EXACT [UniProtKB:P11215] synonym: "CR-3 alpha chain (human)" EXACT [UniProtKB:P11215] synonym: "CR3A" RELATED Gene-based [UniProtKB:P11215] synonym: "hITGAM" EXACT PRO-short-label [PRO:DNx] synonym: "ITGAM" RELATED Gene-based [UniProtKB:P11215] synonym: "leukocyte adhesion receptor MO1 (human)" EXACT [UniProtKB:P11215] synonym: "neutrophil adherence receptor (human)" EXACT [UniProtKB:P11215] xref: UniProtKB:P11215 is_a: PR:000001012 ! integrin alpha-M is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001012 ! integrin alpha-M intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11836 name: B-lymphocyte antigen CD20 (human) namespace: protein def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P11836] comment: Category=organism-gene. synonym: "B-lymphocyte surface antigen B1 (human)" EXACT [UniProtKB:P11836] synonym: "Bp35 (human)" EXACT [UniProtKB:P11836] synonym: "CD20" RELATED Gene-based [UniProtKB:P11836] synonym: "hMS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte surface antigen Leu-16 (human)" EXACT [UniProtKB:P11836] synonym: "membrane-spanning 4-domains subfamily A member 1 (human)" EXACT [UniProtKB:P11836] synonym: "MS4A1" RELATED Gene-based [UniProtKB:P11836] xref: UniProtKB:P11836 is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13379 name: T-cell surface glycoprotein CD5 (mouse) namespace: protein def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse." [OMA:P13379, PRO:DNx] comment: Category=organism-gene. synonym: "Cd5" RELATED Gene-based [UniProtKB:P13379] synonym: "CD5 (mouse)" EXACT [UniProtKB:P13379] synonym: "Ly-1" RELATED Gene-based [UniProtKB:P13379] synonym: "lymphocyte antigen 1 (mouse)" EXACT [UniProtKB:P13379] synonym: "Lyt-1 (mouse)" EXACT [UniProtKB:P13379] synonym: "mCD5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P13379 is_a: PR:000001839 ! T-cell surface glycoprotein CD5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P13591 name: neural cell adhesion molecule 1 (human) namespace: protein def: "A neural cell adhesion molecule 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P13591] comment: Category=organism-gene. synonym: "CD56 (human)" EXACT [UniProtKB:P13591] synonym: "hNCAM1" EXACT PRO-short-label [PRO:DNx] synonym: "N-CAM-1 (human)" EXACT [UniProtKB:P13591] synonym: "NCAM" RELATED Gene-based [UniProtKB:P13591] synonym: "NCAM-1 (human)" EXACT [UniProtKB:P13591] synonym: "NCAM1" RELATED Gene-based [UniProtKB:P13591] xref: UniProtKB:P13591 is_a: PR:000001024 ! neural cell adhesion molecule 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13595 name: neural cell adhesion molecule 1 (mouse) namespace: protein def: "A neural cell adhesion molecule 1 that is encoded in the genome of mouse." [OMA:P13595, PRO:DNx] comment: Category=organism-gene. synonym: "CD56 (mouse)" EXACT [UniProtKB:P13595] synonym: "mNCAM1" EXACT PRO-short-label [PRO:DNx] synonym: "N-CAM-1 (mouse)" EXACT [UniProtKB:P13595] synonym: "Ncam" RELATED Gene-based [UniProtKB:P13595] synonym: "NCAM-1 (mouse)" EXACT [UniProtKB:P13595] synonym: "Ncam1" RELATED Gene-based [UniProtKB:P13595] xref: UniProtKB:P13595 is_a: PR:000001024 ! neural cell adhesion molecule 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15391 name: B-lymphocyte antigen CD19 (human) namespace: protein def: "A CD19 molecule that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "B-lymphocyte surface antigen B4 (human)" EXACT [UniProtKB:P15391] synonym: "CD19" RELATED Gene-based [UniProtKB:P15391] synonym: "differentiation antigen CD19 (human)" EXACT [UniProtKB:P15391] synonym: "hCD19" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen Leu-12 (human)" EXACT [UniProtKB:P15391] xref: UniProtKB:P15391 is_a: PR:000001002 ! CD19 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001002 ! CD19 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16871 name: interleukin-7 receptor subunit alpha (human) namespace: protein def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16871] comment: Category=organism-gene. synonym: "CD127 (human)" EXACT [UniProtKB:P16871] synonym: "CDw127 (human)" EXACT [UniProtKB:P16871] synonym: "hIL7R" EXACT PRO-short-label [PRO:DNx] synonym: "IL-7 receptor subunit alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7R subunit alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7R-alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7RA (human)" EXACT [UniProtKB:P16871] synonym: "IL7R" RELATED Gene-based [UniProtKB:P16871] xref: UniProtKB:P16871 is_a: PR:000001869 ! interleukin-7 receptor subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16872 name: interleukin-7 receptor subunit alpha (mouse) namespace: protein def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P16872, PRO:DNx] comment: Category=organism-gene. synonym: "CD127 (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7 receptor subunit alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7R subunit alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7R-alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7RA (mouse)" EXACT [UniProtKB:P16872] synonym: "Il7r" RELATED Gene-based [UniProtKB:P16872] synonym: "mIL7R" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16872 is_a: PR:000001869 ! interleukin-7 receptor subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P17542 name: T-cell acute lymphocytic leukemia protein 1 (human) namespace: protein def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17542] comment: Category=organism-gene. synonym: "BHLHA17" RELATED Gene-based [UniProtKB:P17542] synonym: "class A basic helix-loop-helix protein 17 (human)" EXACT [UniProtKB:P17542] synonym: "hTAL1" EXACT PRO-short-label [PRO:DNx] synonym: "SCL" RELATED Gene-based [UniProtKB:P17542] synonym: "Stem cell protein (human)" EXACT [UniProtKB:P17542] synonym: "T-cell leukemia/lymphoma protein 5 (human)" EXACT [UniProtKB:P17542] synonym: "TAL-1 (human)" EXACT [UniProtKB:P17542] synonym: "TAL1" RELATED Gene-based [UniProtKB:P17542] synonym: "TCL5" RELATED Gene-based [UniProtKB:P17542] xref: Reactome:R-HSA-8956511 "PR:P17542 located_in GO:0005654" xref: UniProtKB:P17542 is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P19437 name: B-lymphocyte antigen CD20 (mouse) namespace: protein def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse." [OMA:P19437, PRO:DNx] comment: Category=organism-gene. synonym: "B-cell differentiation antigen Ly-44 (mouse)" EXACT [UniProtKB:P19437] synonym: "Cd20" RELATED Gene-based [UniProtKB:P19437] synonym: "CD20 (mouse)" EXACT [UniProtKB:P19437] synonym: "Ly-44" RELATED Gene-based [UniProtKB:P19437] synonym: "lymphocyte antigen 44 (mouse)" EXACT [UniProtKB:P19437] synonym: "membrane-spanning 4-domains subfamily A member 1 (mouse)" EXACT [UniProtKB:P19437] synonym: "mMS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "Ms4a1" RELATED Gene-based [UniProtKB:P19437] synonym: "Ms4a2" RELATED Gene-based [UniProtKB:P19437] xref: UniProtKB:P19437 is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22091 name: T-cell acute lymphocytic leukemia protein 1 homolog (mouse) namespace: protein def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse." [OMA:P22091, PRO:DNx] comment: Category=organism-gene. synonym: "mTAL1" EXACT PRO-short-label [PRO:DNx] synonym: "Scl" RELATED Gene-based [UniProtKB:P22091] synonym: "Stem cell protein (mouse)" EXACT [UniProtKB:P22091] synonym: "Tal-1" RELATED Gene-based [UniProtKB:P22091] synonym: "TAL-1 (mouse)" EXACT [UniProtKB:P22091] synonym: "Tal1" RELATED Gene-based [UniProtKB:P22091] xref: UniProtKB:P22091 is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22646 name: T-cell surface glycoprotein CD3 epsilon chain (mouse) namespace: protein def: "A CD3 epsilon that is encoded in the genome of mouse." [OMA:P22646, PRO:DNx] comment: Category=organism-gene. synonym: "Cd3e" RELATED Gene-based [UniProtKB:P22646] synonym: "CD3e (mouse)" EXACT [UniProtKB:P22646] synonym: "mCD3E" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (mouse)" EXACT [UniProtKB:P22646] xref: UniProtKB:P22646 is_a: PR:000001020 ! CD3 epsilon is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001020 ! CD3 epsilon intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P25918 name: B-lymphocyte antigen CD19 (mouse) namespace: protein def: "A CD19 molecule that is encoded in the genome of mouse." [OMA:P25918, PRO:DNx] comment: Category=organism-gene. synonym: "Cd19" RELATED Gene-based [UniProtKB:P25918] synonym: "CD19 (mouse)" EXACT [UniProtKB:P25918] synonym: "differentiation antigen CD19 (mouse)" EXACT [UniProtKB:P25918] synonym: "mCD19" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P25918 is_a: PR:000001002 ! CD19 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001002 ! CD19 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P28906 name: hematopoietic progenitor cell antigen CD34 (human) namespace: protein def: "A CD34 molecule that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "CD34" RELATED Gene-based [UniProtKB:P28906] synonym: "hCD34" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P28906 is_a: PR:000001003 ! CD34 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001003 ! CD34 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P33151 name: cadherin-5 (human) namespace: protein def: "A cadherin-5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P33151] comment: Category=organism-gene. synonym: "7B4 antigen (human)" EXACT [UniProtKB:P33151] synonym: "CD144 (human)" EXACT [UniProtKB:P33151] synonym: "CDH5" RELATED Gene-based [UniProtKB:P33151] synonym: "hCDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin (human)" EXACT [UniProtKB:P33151] synonym: "VE-cadherin (human)" EXACT [UniProtKB:P33151] xref: UniProtKB:P33151 is_a: PR:000001444 ! cadherin-5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001444 ! cadherin-5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P35461 name: lymphocyte antigen 6G (mouse) namespace: protein def: "A lymphocyte antigen 6G that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P35461] comment: Category=organism-gene. synonym: "Ly-6G (mouse)" EXACT [UniProtKB:P35461] synonym: "Ly-6G.1 (mouse)" EXACT [UniProtKB:P35461] synonym: "Ly6g" RELATED Gene-based [UniProtKB:P35461] synonym: "mLy6g" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P35461 is_a: PR:000002978 ! lymphocyte antigen 6G is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35918 name: vascular endothelial growth factor receptor 2 (mouse) namespace: protein def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse." [OMA:P35918, PRO:DNx] comment: Category=organism-gene. synonym: "CD309 (mouse)" EXACT [UniProtKB:P35918] synonym: "fetal liver kinase 1 (mouse)" EXACT [UniProtKB:P35918] synonym: "Flk-1" RELATED Gene-based [UniProtKB:P35918] synonym: "FLK-1 (mouse)" EXACT [UniProtKB:P35918] synonym: "Flk1" RELATED Gene-based [UniProtKB:P35918] synonym: "Kdr" RELATED Gene-based [UniProtKB:P35918] synonym: "kinase NYK (mouse)" EXACT [UniProtKB:P35918] synonym: "mKDR" EXACT PRO-short-label [PRO:DNx] synonym: "protein-tyrosine kinase receptor flk-1 (mouse)" EXACT [UniProtKB:P35918] synonym: "VEGFR-2 (mouse)" EXACT [UniProtKB:P35918] xref: UniProtKB:P35918 is_a: PR:000002112 ! vascular endothelial growth factor receptor 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35968 name: vascular endothelial growth factor receptor 2 (human) namespace: protein def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P35968] comment: Category=organism-gene. synonym: "CD309 (human)" EXACT [UniProtKB:P35968] synonym: "fetal liver kinase 1 (human)" EXACT [UniProtKB:P35968] synonym: "FLK-1 (human)" EXACT [UniProtKB:P35968] synonym: "FLK1" RELATED Gene-based [UniProtKB:P35968] synonym: "hKDR" EXACT PRO-short-label [PRO:DNx] synonym: "KDR" RELATED Gene-based [UniProtKB:P35968] synonym: "kinase insert domain receptor (human)" EXACT [UniProtKB:P35968] synonym: "protein-tyrosine kinase receptor flk-1 (human)" EXACT [UniProtKB:P35968] synonym: "VEGFR-2 (human)" EXACT [UniProtKB:P35968] synonym: "VEGFR2" RELATED Gene-based [UniProtKB:P35968] xref: DTO:03100560 xref: UniProtKB:P35968 is_a: PR:000002112 ! vascular endothelial growth factor receptor 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P37237 name: fibroblast growth factor 8 (mouse) namespace: protein def: "A fibroblast growth factor 8 that is encoded in the genome of mouse." [OMA:P37237, PRO:DNx] comment: Category=organism-gene. synonym: "Aigf" RELATED Gene-based [UniProtKB:P37237] synonym: "AIGF (mouse)" EXACT [UniProtKB:P37237] synonym: "androgen-induced growth factor (mouse)" EXACT [UniProtKB:P37237] synonym: "FGF-8 (mouse)" EXACT [UniProtKB:P37237] synonym: "Fgf8" RELATED Gene-based [UniProtKB:P37237] synonym: "HBGF-8 (mouse)" RELATED [UniProtKB:P37237] synonym: "heparin-binding growth factor 8 (mouse)" RELATED [UniProtKB:P37237] synonym: "mFGF8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37237 is_a: PR:000007499 ! fibroblast growth factor 8 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007499 ! fibroblast growth factor 8 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55075 name: fibroblast growth factor 8 (human) namespace: protein def: "A fibroblast growth factor 8 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55075] comment: Category=organism-gene. synonym: "AIGF" RELATED Gene-based [UniProtKB:P55075] synonym: "androgen-induced growth factor (human)" EXACT [UniProtKB:P55075] synonym: "FGF-8 (human)" EXACT [UniProtKB:P55075] synonym: "FGF8" RELATED Gene-based [UniProtKB:P55075] synonym: "HBGF-8 (human)" BROAD [UniProtKB:P55075] synonym: "heparin-binding growth factor 8 (human)" BROAD [UniProtKB:P55075] synonym: "hFGF8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P55075 is_a: PR:000007499 ! fibroblast growth factor 8 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007499 ! fibroblast growth factor 8 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P55284 name: cadherin-5 (mouse) namespace: protein def: "A cadherin-5 that is encoded in the genome of mouse." [OMA:P55284, PRO:DNx] comment: Category=organism-gene. synonym: "CD144 (mouse)" EXACT [UniProtKB:P55284] synonym: "Cdh5" RELATED Gene-based [UniProtKB:P55284] synonym: "mCDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin (mouse)" EXACT [UniProtKB:P55284] synonym: "VE-cadherin (mouse)" EXACT [UniProtKB:P55284] xref: UniProtKB:P55284 is_a: PR:000001444 ! cadherin-5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001444 ! cadherin-5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q15465 name: sonic hedgehog protein (human) namespace: protein def: "A sonic hedgehog protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15465] comment: Category=organism-gene. synonym: "HHG-1 (human)" EXACT [UniProtKB:Q15465] synonym: "hSHH" EXACT PRO-short-label [PRO:DNx] synonym: "SHH" RELATED Gene-based [UniProtKB:Q15465] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (human)" EXACT [UniProtKB:Q15465] synonym: "ShhNC (human)" EXACT [UniProtKB:Q15465] xref: UniProtKB:Q15465 is_a: PR:000014841 ! sonic hedgehog protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014841 ! sonic hedgehog protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q62226 name: sonic hedgehog protein (mouse) namespace: protein def: "A sonic hedgehog protein that is encoded in the genome of mouse." [OMA:Q62226, PRO:DNx] comment: Category=organism-gene. synonym: "HHG-1 (mouse)" EXACT [UniProtKB:Q62226] synonym: "Hhg1" RELATED Gene-based [UniProtKB:Q62226] synonym: "mSHH" EXACT PRO-short-label [PRO:DNx] synonym: "Shh" RELATED Gene-based [UniProtKB:Q62226] synonym: "SHH (mouse)" EXACT [UniProtKB:Q62226] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)" EXACT [UniProtKB:Q62226] synonym: "ShhNC (mouse)" EXACT [UniProtKB:Q62226] xref: UniProtKB:Q62226 is_a: PR:000014841 ! sonic hedgehog protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014841 ! sonic hedgehog protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62351 name: transferrin receptor protein 1 (mouse) namespace: protein def: "A transferrin receptor protein 1 that is encoded in the genome of mouse." [OMA:Q62351, PRO:DNx] comment: Category=organism-gene. synonym: "CD71 (mouse)" EXACT [UniProtKB:Q62351] synonym: "mTFRC" EXACT PRO-short-label [PRO:DNx] synonym: "TfR (mouse)" EXACT [UniProtKB:Q62351] synonym: "TfR1 (mouse)" EXACT [UniProtKB:Q62351] synonym: "Tfrc" RELATED Gene-based [UniProtKB:Q62351] synonym: "TR (mouse)" RELATED [UniProtKB:Q62351] synonym: "Trfr" RELATED Gene-based [UniProtKB:Q62351] xref: UniProtKB:Q62351 is_a: PR:000001945 ! transferrin receptor protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q64314 name: hematopoietic progenitor cell antigen CD34 (mouse) namespace: protein def: "A CD34 molecule that is encoded in the genome of mouse." [OMA:Q64314, PRO:DNx] comment: Category=organism-gene. synonym: "Cd34" RELATED Gene-based [UniProtKB:Q64314] synonym: "CD34 (mouse)" EXACT [UniProtKB:Q64314] synonym: "mCD34" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q64314 is_a: PR:000001003 ! CD34 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001003 ! CD34 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: RO:0002577 name: system def: "A material entity consisting of multiple components that are causally integrated." [] is_a: BFO:0000040 ! material entity property_value: editor_note "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" xsd:string [Term] id: UBERON:0000000 name: processual entity namespace: uberon def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level xref: BFO:0000003 is_a: BFO:0000003 ! occurrent disjoint_from: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000005 name: chemosensory organ namespace: uberon subset: functional_classification subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "chemosensory sensory organ" EXACT [FBbt:00005157] xref: FBbt:00005157 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000020 ! sense organ intersection_of: UBERON:0000020 ! sense organ intersection_of: capable_of GO:0007606 ! sensory perception of chemical stimulus relationship: capable_of GO:0007606 ! sensory perception of chemical stimulus relationship: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0005726 ! chemosensory system [Term] id: UBERON:0000006 name: islet of Langerhans namespace: uberon def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "island of Langerhans" RELATED [BTO:0000991] synonym: "island of pancreas" RELATED [BTO:0000991] synonym: "islets of Langerhans" RELATED [] synonym: "pancreatic insula" EXACT [] synonym: "pancreatic islet" EXACT [] xref: AAO:0010406 xref: BTO:0000991 xref: CALOHA:TS-0741 xref: EFO:0000856 xref: EMAPA:32927 xref: EV:0100130 xref: FMA:16016 xref: GAID:324 xref: MA:0000127 xref: MAT:0000076 xref: MESH:D007515 xref: MIAA:0000076 xref: NCIT:C12608 xref: UMLS:C0022131 {source="ncithesaurus:Islet_of_Langerhans"} xref: VHOG:0000646 xref: Wikipedia:Islets_of_Langerhans xref: XAO:0000159 is_a: UBERON:0034922 ! cell cluster relationship: contributes_to_morphology_of UBERON:0000016 ! endocrine pancreas relationship: has_part CL:0000168 {source="PMID:16417468"} ! insulin secreting cell relationship: has_part CL:0000172 {source="PMID:16417468"} ! somatostatin secreting cell relationship: has_part CL:0000696 {gci_filler="NCBITaxon:117570", gci_relation="part_of", source="PMID:16417468"} ! PP cell relationship: has_part CL:0002067 {source="PMID:16417468"} ! type A enteroendocrine cell relationship: part_of UBERON:0000016 ! endocrine pancreas property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010406", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000646", ontology="VHOG", source="PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" xsd:string {source="PMID:16417468"} property_value: UBPROP:0000202 FMA:76489 [Term] id: UBERON:0000009 name: submucosa namespace: uberon def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." [Wikipedia:Submucosa] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "organ submucosa" EXACT [FMA:85391] synonym: "region of submucosa" EXACT [FMA:85392] synonym: "submucosa of organ" EXACT [FMA:85391] synonym: "submucosa of region of organ" EXACT [FMA:85392] synonym: "submucous layer" RELATED [BTO:0002107] synonym: "tela submucosa" RELATED [BTO:0002107] synonym: "tunica submucosa" RELATED [] xref: BTO:0002107 xref: FMA:85391 xref: FMA:85392 xref: NCIT:C13167 xref: SCTID:68439008 xref: UMLS:C0225344 {source="ncithesaurus:Submucosa"} xref: Wikipedia:Submucosa is_a: UBERON:0004923 ! organ component layer relationship: composed_primarily_of UBERON:0002384 ! connective tissue relationship: immediately_deep_to UBERON:0000344 ! mucosa relationship: in_taxon NCBITaxon:7711 ! Chordata property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png xsd:anyURI property_value: UBPROP:0000007 "submucosal" xsd:string [Term] id: UBERON:0000010 name: peripheral nervous system namespace: uberon def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pars peripherica" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system] synonym: "PNS" BROAD OMO:0003000 [] synonym: "systema nervosum periphericum" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system] xref: AAO:0000429 xref: BAMS:PNS xref: BILA:0000081 xref: BIRNLEX:1111 xref: BTO:0001028 xref: CALOHA:TS-0808 xref: EFO:0000891 xref: EHDAA2:0001445 xref: EHDAA:2893 xref: EMAPA:16665 xref: EV:0100335 xref: FBbt:00005098 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9903 xref: GAID:715 xref: MA:0000218 xref: MAT:0000338 xref: MESH:D017933 xref: MIAA:0000338 xref: NCIT:C12465 xref: neuronames:3232 xref: SCTID:362292005 xref: TAO:0000142 xref: UMLS:C0206417 {source="ncithesaurus:Peripheral_Nervous_System", source="BIRNLEX:1111"} xref: UMLS:C1305921 {source="BIRNLEX:1111"} xref: VHOG:0000399 xref: Wikipedia:Peripheral_nervous_system xref: XAO:0000178 xref: ZFA:0000142 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: part_of UBERON:0001016 ! nervous system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000142", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000429", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"} property_value: UBPROP:0000003 "(...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000399", ontology="VHOG", source="DOI:10.1007/978-0-387-46954-6_6 Dupin E, Creuzet S, Le Douarin NM, The contribution of the neural crest to the vertebrate body. Advances in experimental medicine and biology (2006)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000013 name: sympathetic nervous system namespace: uberon def: "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [GO:0048485] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pars sympathica divisionis autonomici systematis nervosi" EXACT OMO:0003011 [FMA:9906, FMA:TA] synonym: "pars sympathica divisionis autonomici systematis nervosi" RELATED OMO:0003011 [Wikipedia:Sympathetic_nervous_system] synonym: "sympathetic nervous system" EXACT [] synonym: "sympathetic part of autonomic division of nervous system" EXACT [] xref: AAO:0010487 xref: BIRNLEX:2516 xref: BTO:0001832 xref: CALOHA:TS-2050 xref: EFO:0000893 xref: EHDAA2:0001971 xref: EHDAA:3769 xref: EMAPA:16985 xref: FMA:9906 xref: GAID:710 xref: MA:0000225 xref: MESH:D013564 xref: MIAA:0000100 xref: NCIT:C12795 xref: SCTID:362484004 xref: TAO:0001576 xref: UMLS:C0039044 {source="BIRNLEX:2516", source="ncithesaurus:Sympathetic_Nervous_System"} xref: UMLS:C1269646 {source="BIRNLEX:2516"} xref: VHOG:0000384 xref: Wikipedia:Sympathetic_nervous_system xref: ZFA:0001576 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 {source="FMA", source="MA", source="ZFA-modified-from-isa"} ! autonomic nervous system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png xsd:anyURI property_value: UBPROP:0000001 "Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010487", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.461-463", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "has developmental contribution from NC in verteberates (https://github.com/obophenotype/uberon/wiki/The-neural-crest)" xsd:string [Term] id: UBERON:0000014 name: zone of skin namespace: uberon def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Skin] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "portion of skin" EXACT [] synonym: "region of skin" EXACT [] synonym: "skin" EXACT [MA:0000151] synonym: "skin region" EXACT [] synonym: "skin zone" EXACT [] xref: EHDAA:6530 xref: EV:0100152 xref: FMA:86166 xref: GAID:933 xref: MA:0000151 xref: MAT:0000284 xref: MESH:D012867 xref: MIAA:0000284 xref: SCTID:20795001 xref: VHOG:0000860 xref: Wikipedia:Skin is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034944 {source="FMA"} ! zone of organ relationship: has_part UBERON:0001003 ! skin epidermis relationship: has_part UBERON:0002067 ! dermis relationship: part_of UBERON:0002097 ! skin of body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg xsd:anyURI property_value: IAO:0000232 "Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee" xsd:string property_value: UBPROP:0000003 "(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000860", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive" xsd:string [Term] id: UBERON:0000015 name: non-material anatomical boundary namespace: uberon def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010] comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "anatomical boundary" EXACT [CARO:0000010] xref: AEO:0000192 xref: CARO:0000010 xref: FMA:50705 is_a: UBERON:0000466 {source="CARO"} ! immaterial anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000016 name: endocrine pancreas namespace: uberon def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocrine pancreas" EXACT [] synonym: "endocrine part of pancreas" RELATED [BTO:0000650] synonym: "islets of Langerhans part of pancreas" RELATED [] synonym: "pars endocrina pancreatis" EXACT [] xref: BTO:0000650 xref: CALOHA:TS-1302 xref: EFO:0002542 xref: EMAPA:35305 xref: EV:0100129 xref: FMA:16018 xref: MA:0001582 xref: MESH:D007515 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C32509 xref: SCTID:361339003 xref: TAO:0001260 xref: VHOG:0000049 xref: Wikipedia:Islets_of_Langerhans xref: ZFA:0001260 is_a: UBERON:0000471 {source="ZFA"} ! compound organ component is_a: UBERON:0004119 ! endoderm-derived structure relationship: capable_of GO:0030073 {source="GO"} ! insulin secretion relationship: capable_of GO:0070091 {source="GO"} ! glucagon secretion relationship: capable_of GO:0070253 {source="GO"} ! somatostatin secretion relationship: composed_primarily_of UBERON:0000006 ! islet of Langerhans relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas relationship: develops_from UBERON:0003923 ! dorsal pancreatic bud relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000949 {source="AAO", source="FMA", source="XAO"} ! endocrine system relationship: part_of UBERON:0001264 ! pancreas property_value: editor_note "create a separate class for distributed pancreas, eg cyclostomes?" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"} property_value: UBPROP:0000001 "The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001260", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys" xsd:string {source="PMID:20959416"} [Term] id: UBERON:0000017 name: exocrine pancreas namespace: uberon def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "exocrine component of pancreas" RELATED [] synonym: "exocrine pancreas" EXACT [] synonym: "exocrine part of pancreas" RELATED [BTO:0000434] synonym: "pars exocrina pancreatis" EXACT [] xref: AAO:0010407 xref: BTO:0000434 xref: CALOHA:TS-1241 xref: EMAPA:35328 xref: EV:0100093 xref: FMA:16017 xref: MA:0002415 xref: MESH:D046790 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C32546 xref: SCTID:248202004 xref: TAO:0001249 xref: UMLS:C0553695 {source="ncithesaurus:Exocrine_Pancreas"} xref: VHOG:0000048 xref: Wikipedia:Exocrine_component_of_pancreas xref: XAO:0000137 xref: ZFA:0001249 is_a: UBERON:0000409 ! serous gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0013765 ! digestive system element relationship: capable_of_part_of GO:0007586 ! digestion relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas relationship: develops_from UBERON:0003924 ! ventral pancreatic bud relationship: has_part UBERON:0001263 ! pancreatic acinus relationship: has_part UBERON:0007329 ! pancreatic duct relationship: part_of UBERON:0001264 ! pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001249", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000018 name: compound eye namespace: uberon def: "A light sensing organ composed of ommatidia." [FB:gg, Wikipedia:Compound_eye] subset: organ_slim subset: uberon_slim synonym: "adult compound eye" RELATED [] synonym: "faceted eye" RELATED [] synonym: "Facettenauge" RELATED [BTO:0001921] synonym: "insect eye" RELATED [] synonym: "Komplexauge" RELATED [BTO:0001921] synonym: "zusammengesetztes Auge" RELATED [BTO:0001921] xref: BTO:0001921 xref: FBbt:00004508 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000217 xref: IDOMAL:0002421 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: TGMA:0000024 xref: Wikipedia:Compound_eye is_a: UBERON:0015165 ! multi-unit eye intersection_of: UBERON:0000970 ! eye intersection_of: composed_primarily_of UBERON:0000971 ! ommatidium relationship: composed_primarily_of UBERON:0000971 ! ommatidium relationship: in_taxon NCBITaxon:6656 {source="PMID:21062451"} ! Arthropoda property_value: seeAlso https://github.com/obophenotype/uberon/issues/457 xsd:anyURI property_value: UBPROP:0000008 "The term compound eye is sometimes used for the multi-unit eyes of annelids, bivalves, echinoderms. We follow Richter et al and restrict this class to the arthropod structure for these structures" xsd:string {source="PMID:21062451"} [Term] id: UBERON:0000019 name: camera-type eye namespace: uberon def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." [GO:0043010, https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "camera-type eye plus associated structures" RELATED [] synonym: "eye" BROAD [FMA:54448] synonym: "eyes" RELATED OMO:0003004 [TAO:0000107] synonym: "orbital part of face" RELATED [FMA:54448] synonym: "orbital region" RELATED [FMA:54448] synonym: "regio orbitalis" EXACT OMO:0003011 [FMA:54448, FMA:TA] synonym: "vertebrate eye" NARROW [] xref: AAO:0010340 xref: BIRNLEX:1169 xref: BTO:0004688 xref: EHDAA2:0000484 xref: EHDAA:936 xref: EMAPA:16198 xref: FMA:54448 xref: MA:0000261 xref: NCIT:C12401 xref: SCTID:181143004 xref: TAO:0000107 xref: UMLS:C0015392 {source="BIRNLEX:1169", source="ncithesaurus:Eye"} xref: UMLS:C1280202 {source="BIRNLEX:1169"} xref: VHOG:0000275 xref: XAO:0000179 xref: ZFA:0000107 is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure relationship: develops_from UBERON:0003072 {evidence="definitional"} ! optic cup relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0000965 ! lens of camera-type eye relationship: has_part UBERON:0000966 ! retina relationship: in_lateral_side_of UBERON:0000033 ! head relationship: part_of UBERON:0004088 ! orbital region property_value: UBPROP:0000001 "A cavitated compound organ that transduces light waves into neural signals.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000107", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000275", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000020 name: sense organ namespace: uberon def: "An organ that is capable of transducing sensory stimulus to the nervous system." [https://github.com/obophenotype/uberon/issues/549, https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "organ of sense organ system" EXACT [OBOL:accepted] synonym: "organ of sensory organ system" EXACT [OBOL:accepted] synonym: "organ of sensory system" EXACT [OBOL:accepted] synonym: "sense organ system organ" EXACT [OBOL:automatic] synonym: "sensillum" NARROW [WBbt:0006929] synonym: "sensor" RELATED [] synonym: "sensory organ" EXACT [] synonym: "sensory organ system organ" EXACT [OBOL:automatic] synonym: "sensory system organ" EXACT [OBOL:accepted] synonym: "Sinnesorgan" RELATED [BTO:0000202] xref: AEO:0000094 xref: BSA:0000121 xref: BTO:0000202 xref: CALOHA:TS-2043 xref: EHDAA2:0001824 xref: EHDAA:500 xref: EMAPA:35955 xref: FBbt:00005155 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:63 xref: HAO:0000930 xref: MA:0000017 xref: MESH:D012679 xref: NCIT:C33224 xref: SCTID:244485009 xref: UMLS:C0935626 {source="ncithesaurus:Organ_of_the_Special_Sense"} xref: VHOG:0001407 xref: WBbt:0006929 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of UBERON:0001032 ! sensory system property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png xsd:anyURI [Term] id: UBERON:0000025 name: tube namespace: uberon def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "anatomical tube" EXACT [] synonym: "duct" NARROW [] xref: galen:Tube is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: has_quality PATO:0002299 ! tubular relationship: has_part UBERON:0013522 ! subdivision of tube relationship: has_quality PATO:0002299 ! tubular property_value: IAO:0000232 "not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)" xsd:string property_value: UBPROP:0000007 "tubular" xsd:string [Term] id: UBERON:0000026 name: appendage namespace: uberon def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." [CARO:DOS] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "appendages" RELATED OMO:0003004 [XAO:0000218] synonym: "extremitaet" RELATED [BTO:0001492] synonym: "extremity" RELATED [] synonym: "limbs/digits/tail" RELATED [MP:0000001] xref: AEO:0000193 xref: BILA:0000018 xref: BTO:0001492 xref: CARO:0010003 xref: EFO:0000799 xref: EHDAA2:0003193 xref: EMAPA:37283 {source="MA:th"} xref: EV:0100155 xref: FBbt:00007000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000144 xref: MAT:0000023 xref: MESH:D005121 xref: MIAA:0000023 xref: NCIT:C61460 xref: UMLS:C0598782 {source="ncithesaurus:Appendage"} xref: VSAO:0000075 xref: Wikipedia:Appendage xref: XAO:0000218 is_a: UBERON:0000475 ! organism subdivision relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: UBPROP:0000001 "An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]." xsd:string {source="BILA:0000018"} property_value: UBPROP:0000001 "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]." xsd:string {source="GO:0048736"} property_value: UBPROP:0000007 "appendicular" xsd:string property_value: UBPROP:0000008 "this is currently a subtype of organism subdivision - which would exclude feathers" xsd:string [Term] id: UBERON:0000030 name: lamina propria namespace: uberon def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [Wikipedia:Lamina_propria] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "lamina propria mucosa" EXACT [] synonym: "lamina propria mucosae" EXACT [] synonym: "tunica propria" RELATED [BTO:0002330] xref: BTO:0002330 xref: FMA:62517 xref: NCIT:C32918 xref: SCTID:298225002 xref: UMLS:C1179187 {source="ncithesaurus:Lamina_Propria"} xref: Wikipedia:Lamina_propria is_a: UBERON:0004923 ! organ component layer relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue relationship: immediately_deep_to UBERON:0000483 ! epithelium relationship: part_of UBERON:0000344 ! mucosa property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg xsd:anyURI [Term] id: UBERON:0000031 name: lamina propria of trachea namespace: uberon def: "A lamina propria that is part of a respiratory airway." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "lamina propria mucosa of trachea" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of windpipe" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of trachea" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of windpipe" EXACT [OBOL:automatic] synonym: "lamina propria of windpipe" EXACT [OBOL:automatic] synonym: "trachea lamina propria" EXACT [] synonym: "trachea lamina propria mucosa" EXACT [OBOL:automatic] synonym: "trachea lamina propria mucosae" EXACT [OBOL:automatic] synonym: "tracheal lamina propria" EXACT [] synonym: "windpipe lamina propria" EXACT [OBOL:automatic] synonym: "windpipe lamina propria mucosa" EXACT [OBOL:automatic] synonym: "windpipe lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:35877 xref: FMA:265157 xref: MA:0001858 xref: NCIT:C49305 xref: UMLS:C1710457 {source="ncithesaurus:Trachea_Lamina_Propria"} is_a: UBERON:0004779 ! respiratory system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001005 ! respiratory airway relationship: part_of UBERON:0000379 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! tracheal mucosa [Term] id: UBERON:0000033 name: head namespace: uberon def: "The head is the anterior-most division of the body [GO]." [GO:0060322, Wikipedia:Head] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adult head" NARROW [] synonym: "cephalic area" RELATED [SPD:0000016] synonym: "head (volume)" EXACT [FMA:7154] xref: AAO:0010335 xref: AEO:0000106 xref: BILA:0000115 xref: BIRNLEX:1230 xref: BTO:0000282 xref: CALOHA:TS-0436 xref: EFO:0000964 xref: EHDAA2:0003106 xref: EMAPA:31858 xref: FMA:7154 xref: GAID:61 xref: galen:Head xref: HAO:0000397 xref: MA:0000023 xref: MAT:0000294 xref: MESH:D006257 xref: MIAA:0000294 xref: NCIT:C12419 xref: SCTID:302548004 xref: SPD:0000016 xref: TAO:0001114 xref: TGMA:0000002 xref: UMLS:C0018670 {source="ncithesaurus:Head", source="BIRNLEX:1230"} xref: VHOG:0001644 xref: WBbt:0005739 xref: Wikipedia:Head xref: XAO:0003024 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: has_skeleton UBERON:0003129 {gci_relation="part_of", gci_filler="NCBITaxon:7776"} ! skull relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of UBERON:0007811 ! craniocervical region property_value: RO:0002171 UBERON:0000948 property_value: UBPROP:0000001 "Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010335", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001114", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001644", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.82", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000042 name: serous membrane namespace: uberon def: "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Serous_membrane] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "serosa" RELATED [Wikipedia:Serous_membrane] synonym: "tunica serosa" EXACT OMO:0003011 [FMA:9581] synonym: "wall of serous sac" EXACT [FMA:9581] xref: FMA:9581 xref: GAID:19 xref: MESH:D012704 xref: NCIT:C13169 xref: SCTID:362878009 xref: TAO:0005425 xref: UMLS:C0036760 {source="ncithesaurus:Serosa"} xref: Wikipedia:Serous_membrane xref: ZFA:0005425 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: has_part UBERON:0001136 ! mesothelium relationship: has_part UBERON:0002384 ! connective tissue relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000060 ! anatomical wall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png xsd:anyURI property_value: UBPROP:0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005425", ontology="TAO", source="Wikipedia:Serous_membrane"} property_value: UBPROP:0000001 "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" xsd:string {source="Wikipedia:Serous_membrane"} property_value: UBPROP:0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000043 name: tendon namespace: uberon def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073, Wikipedia:Tendon] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "sinew" RELATED [Wikipedia:Tendon] synonym: "tendo" RELATED OMO:0003011 [Wikipedia:Tendon] xref: AEO:0000091 xref: BTO:0001356 xref: CALOHA:TS-1021 xref: EHDAA2:0003091 xref: EMAPA:35854 xref: EV:0100149 xref: FMA:9721 xref: GAID:276 xref: galen:Tendon xref: MA:0000115 xref: MESH:D013710 xref: NCIT:C13045 xref: SCTID:256667004 xref: UMLS:C0039508 {source="ncithesaurus:Tendon"} xref: VHOG:0001286 xref: VSAO:0000073 xref: Wikipedia:Tendon xref: XAO:0000173 xref: ZFA:0005647 is_a: UBERON:0007846 {source="VSAO"} ! dense regular connective tissue relationship: connects UBERON:0001474 ! bone element relationship: connects UBERON:0001630 ! muscle organ relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg xsd:anyURI property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001286", ontology="VHOG", source="DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000045 name: ganglion namespace: uberon def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Ganglion] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ganglia" RELATED [] synonym: "neural ganglion" RELATED [BTO:0000497] xref: AAO:0010426 xref: AEO:0000135 xref: BAMS:G xref: BTO:0000497 xref: CALOHA:TS-0397 xref: EFO:0000899 xref: EHDAA2:0003135 xref: EHDAA:2897 xref: EHDAA:4662 xref: EHDAA:5621 xref: EHDAA:918 xref: EMAPA:32846 xref: EV:0100372 xref: FMA:5884 xref: MA:0002406 xref: MAT:0000207 xref: MAT:0000343 xref: MESH:D005724 xref: MIAA:0000207 xref: MIAA:0000343 xref: NCIT:C12719 xref: NLXANAT:100302 xref: TAO:0000190 xref: TGMA:0001016 xref: UMLS:C0017067 {source="ncithesaurus:Ganglion"} xref: VHOG:0000156 xref: WBbt:0005189 xref: Wikipedia:Ganglion xref: XAO:0000209 xref: ZFA:0000190 is_a: UBERON:0000061 {source="https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719"} ! anatomical structure relationship: composed_primarily_of UBERON:0003714 {source="EHDAA2"} ! neural tissue relationship: develops_from UBERON:0000922 ! embryo relationship: develops_from UBERON:0003869 ! presumptive ganglion relationship: immediate_transformation_of UBERON:0003869 {source="Bgee:AN"} ! presumptive ganglion relationship: part_of UBERON:0001016 ! nervous system property_value: editor_note "TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system." xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures" xsd:string {source="PMID:21062451"} property_value: UBPROP:0000001 "Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010426", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000190", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302]." xsd:string {source="NLXANAT:100302"} property_value: UBPROP:0000003 "Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000156", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.02.021 Mazet F, Hutt JA, Milloz J, Millard J, Graham A, Shimeld SM, Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. Developmental Biology (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "ganglionic" xsd:string [Term] id: UBERON:0000047 name: simple eye namespace: uberon def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [Wikipedia:Eye#Simple_eyes] subset: grouping_class subset: human_subset subset: mouse_subset subset: uberon_slim xref: TGMA:0000729 xref: Wikipedia:Eye#Simple_eyes is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000055 name: vessel namespace: uberon def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0006314 ! bodily fluid property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000058 name: duct namespace: uberon def: "A tubular structure that transports secreted or excreted substances." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm#ducts] subset: grouping_class subset: human_subset subset: mouse_subset synonym: "anatomical duct" EXACT [] synonym: "ducts" RELATED OMO:0003004 [XAO:0004000] synonym: "exocrine duct" NARROW [] synonym: "exocrine gland duct" NARROW [] xref: AAO:0011123 xref: FBbt:00100314 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:30320 xref: galen:Duct xref: NCIT:C12948 xref: SCTID:91726008 xref: TAO:0005171 xref: UMLS:C0687028 {source="ncithesaurus:Duct"} xref: Wikipedia:Duct_(anatomy) xref: XAO:0004000 xref: ZFA:0005171 is_a: UBERON:0000063 ! organ subunit relationship: conduit_for UBERON:0000463 ! organism substance relationship: has_part UBERON:0034969 ! epithelial layer of duct relationship: has_quality PATO:0002299 ! tubular property_value: UBPROP:0000001 "A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]." xsd:string {source="ZFA:0005171"} property_value: UBPROP:0000012 "Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here." xsd:string [Term] id: UBERON:0000059 name: large intestine namespace: uberon def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "intestinum crassum" RELATED [BTO:0000706] xref: AAO:0010396 xref: BTO:0000706 xref: CALOHA:TS-1306 xref: EFO:0000840 xref: EMAPA:19252 xref: EV:0100077 xref: FMA:7201 xref: GAID:306 xref: galen:LargeIntestine xref: MA:0000333 xref: MESH:D007420 xref: MIAA:0000046 xref: NCIT:C12379 xref: SCTID:181254001 xref: UMLS:C0021851 {source="ncithesaurus:Large_Intestine"} xref: VHOG:0000054 xref: Wikipedia:Large_intestine_(anatomy) xref: XAO:0000131 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: contributes_to_morphology_of UBERON:0000160 ! intestine relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0004907 ! lower digestive tract property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000054", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000060 name: anatomical wall namespace: uberon alt_id: UBERON:0009915 def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [FMA:82482] subset: human_subset subset: mouse_subset subset: upper_level synonym: "organ wall" RELATED [FMA:82482] synonym: "wall" BROAD [] synonym: "wall of organ" EXACT [FMA:82482] xref: FMA:82482 xref: galen:Wall is_a: UBERON:0000064 ! organ part relationship: adjacent_to UBERON:0002553 ! anatomical cavity relationship: has_part UBERON:0004923 ! organ component layer property_value: UBPROP:0000012 "in FMA, serosa is a wall" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000061 name: anatomical structure namespace: uberon def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] subset: common_anatomy subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: upper_level synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [CARO:0000003] xref: AAO:0010825 xref: AEO:0000003 xref: BILA:0000003 xref: CARO:0000003 xref: EHDAA2:0003003 xref: EMAPA:0 xref: FBbt:00007001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:305751 xref: FMA:67135 xref: GAID:781 xref: HAO:0000003 xref: http://dbpedia.org/ontology/AnatomicalStructure xref: MA:0003000 xref: MESH:D000825 xref: SCTID:362889002 xref: TAO:0000037 xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 is_a: UBERON:0000465 ! material anatomical entity relationship: existence_ends_during_or_before UBERON:0000071 ! death stage relationship: existence_starts_during_or_after UBERON:0000106 {gci_relation="in_taxon", gci_filler="NCBITaxon:33208"} ! zygote stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000062 name: organ namespace: uberon def: "Anatomical structure that performs a specific function or group of functions [WP]." [Wikipedia:Organ_(anatomy)] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "anatomical unit" RELATED [] synonym: "body organ" RELATED [] synonym: "element" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BIRNLEX:4 xref: CARO:0020004 xref: EFO:0000634 xref: EMAPA:35949 xref: ENVO:01000162 xref: FMA:67498 xref: MA:0003001 xref: NCIT:C13018 xref: SCTID:272625005 xref: UMLS:C0178784 {source="ncithesaurus:Organ"} xref: WBbt:0003760 xref: Wikipedia:Organ_(anatomy) is_a: UBERON:0010000 ! multicellular anatomical structure disjoint_from: UBERON:0034921 ! multi organ part structure relationship: capable_of GO:0008150 ! biological_process relationship: existence_starts_during_or_after UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! organogenesis stage relationship: has_boundary UBERON:0006984 ! anatomical surface relationship: part_of UBERON:0000467 ! anatomical system property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000001 "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." xsd:string {source="GO:0048513"} property_value: UBPROP:0000012 "CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4" xsd:string [Term] id: UBERON:0000063 name: organ subunit namespace: uberon def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: upper_level synonym: "organ region with fixed fiat boundary" RELATED [FMA:86140] synonym: "organ segment" RELATED [FMA:86140] synonym: "segment of organ" RELATED [FMA:86140] xref: FMA:86140 is_a: UBERON:0000064 ! organ part property_value: editor_note "FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction" xsd:string property_value: UBPROP:0000001 "Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball." xsd:string {source="FMA:86140", version="3"} property_value: UBPROP:0000001 "Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal." xsd:string {source="FMA:86140", version="1"} [Term] id: UBERON:0000064 name: organ part namespace: uberon def: "A multicellular structure that is a part of an organ." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: efo_slim subset: human_subset subset: mouse_subset subset: non_informative subset: upper_level synonym: "cardinal organ part" EXACT [FMA:82472] synonym: "regional part of organ" RELATED [BIRNLEX:16] xref: AAO:0011124 xref: BIRNLEX:16 xref: EFO:0000635 xref: FMA:82472 xref: SCTID:113343008 xref: SCTID:91717005 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: part_of UBERON:0000062 ! organ property_value: IAO:0000232 "currently defined in a very broad sense, may be replaced by more specific classes in the future" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000065 name: respiratory tract namespace: uberon def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: EHDAA2:0001606 xref: EHDAA:1568 xref: EHDAA:2219 xref: EMAPA:16737 xref: FMA:265130 xref: SCTID:361110005 xref: VHOG:0000393 is_a: UBERON:0001005 ! respiratory airway relationship: develops_from UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut relationship: develops_from UBERON:0008947 ! respiratory primordium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000066 name: fully formed stage namespace: uberon def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "adult stage" BROAD [] synonym: "fully formed animal stage" EXACT [] synonym: "juvenile-adult stage" EXACT [] xref: BilaDO:0000004 xref: BtauDv:0000078 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BTO:0001043 xref: CfamDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000014 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000005 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000005 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001272 xref: FBdv:00005369 xref: FcatDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000076 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000032 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0010000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000052 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000092 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000024 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PpanDv:0000041 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000052 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000061 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000040 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000084 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000041 xref: XtroDO:0000084 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000092 ! post-embryonic stage relationship: preceded_by UBERON:0000111 ! organogenesis stage relationship: preceded_by UBERON:0004729 {gci_relation="part_of", gci_filler="NCBITaxon:6239"} ! nematode larval stage relationship: precedes UBERON:0000071 ! death stage property_value: seeAlso https://github.com/obophenotype/uberon/issues/566 xsd:anyURI [Term] id: UBERON:0000068 name: embryo stage namespace: uberon def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "embryogenesis" RELATED [] synonym: "embryonic stage" EXACT [] xref: AcarDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BilaDO:0000002 xref: BtauDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EV:0300001 xref: FBdv:00005289 xref: FcatDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FMA:72652 xref: GgalDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000045 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000042 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000000 xref: OGES:000022 xref: PpanDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SCTID:296280003 xref: SsalDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000002 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000003 xref: WBls:0000092 xref: WBls:0000102 xref: XAO:1000012 is_a: UBERON:0000105 ! life cycle stage disjoint_from: UBERON:0000092 ! post-embryonic stage relationship: precedes UBERON:0000066 ! fully formed stage relationship: precedes UBERON:0000092 ! post-embryonic stage relationship: simultaneous_with GO:0009790 ! embryo development [Term] id: UBERON:0000069 name: larval stage namespace: uberon def: "A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva] subset: efo_slim synonym: "ammocoete" NARROW SENSU [Wikipedia:Larva] synonym: "ammocoete stage" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria stage" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar stage" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium stage" NARROW SENSU [Wikipedia:Larva] synonym: "grub" NARROW SENSU [Wikipedia:Larva] synonym: "grub stage" NARROW SENSU [Wikipedia:Larva] synonym: "larva" RELATED [] synonym: "larva stage" EXACT [] synonym: "leptocephalus" NARROW SENSU [Wikipedia:Larva] synonym: "leptocephalus stage" NARROW SENSU [Wikipedia:Larva] synonym: "maggot" NARROW SENSU [Wikipedia:Larva] synonym: "maggot stage" NARROW SENSU [Wikipedia:Larva] synonym: "metacestode" NARROW SENSU [BTO:0000859] synonym: "naiad, nymph" NARROW SENSU [Wikipedia:Larva] synonym: "naiad, nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius stage" NARROW SENSU [Wikipedia:Larva] synonym: "nymph" NARROW SENSU [Wikipedia:Larva] synonym: "nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "planula" NARROW SENSU [Wikipedia:Larva] synonym: "planula stage" NARROW SENSU [Wikipedia:Larva] synonym: "tornaria" NARROW SENSU [NCBITaxon:10219] synonym: "trochophore" NARROW SENSU [Wikipedia:Larva] synonym: "trochophore stage" NARROW SENSU [Wikipedia:Larva] synonym: "veliger" NARROW SENSU [Wikipedia:Larva] synonym: "veliger stage" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler stage" NARROW SENSU [Wikipedia:Larva] synonym: "zoea" NARROW SENSU [Wikipedia:Larva] synonym: "zoea stage" NARROW SENSU [Wikipedia:Larva] xref: BTO:0000915 xref: BTO:0000954 xref: DpseDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001303 xref: MIAA:0000400 xref: OGES:000008 xref: SsalDv:0000039 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Larva xref: ZFS:0000048 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0000068 ! embryo stage relationship: part_of UBERON:0000092 ! post-embryonic stage relationship: simultaneous_with GO:0002164 ! larval development property_value: IAO:0000232 "Uberon includes clade-specific subclasses, e.g. nematod larva" xsd:string property_value: RO:0002161 NCBITaxon:32524 property_value: UBPROP:0000008 "It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form" xsd:string {source="WP"} [Term] id: UBERON:0000071 name: death stage namespace: uberon def: "End of the life of an organism." [XAO:0000437] subset: common_anatomy subset: human_subset subset: mouse_subset synonym: "death" RELATED [] xref: XAO:0000437 xref: XtroDO:0000085 is_a: UBERON:0000105 ! life cycle stage relationship: ends UBERON:0000104 ! life cycle property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000012 "ncit:Death is an outcome" xsd:string {external_ontology="ncit"} [Term] id: UBERON:0000072 name: proximo-distal subdivision of respiratory tract namespace: uberon def: "An section of a respiratory tract." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: non_informative synonym: "respiratory tract" RELATED [MA:0000434] synonym: "subdivision of respiratory tract" RELATED [] xref: FMA:45660 xref: MA:0000434 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole" xsd:string {external_ontology="MA"} [Term] id: UBERON:0000073 name: regional part of nervous system namespace: uberon def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." [BIRNLEX:1157] subset: human_subset subset: mouse_subset subset: non_informative subset: upper_level synonym: "part of nervous system" EXACT [BIRNLEX:1157] xref: BIRNLEX:1157 xref: NCIT:C13040 xref: SCTID:25087005 xref: UMLS:C1518256 {source="ncithesaurus:Nervous_System_Part"} is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0001016 ! nervous system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2009-06-18T09:00:04Z [Term] id: UBERON:0000075 name: subdivision of skeletal system namespace: uberon alt_id: UBERON:0010322 def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: human_subset subset: mouse_subset subset: non_informative synonym: "skeletal system part" RELATED [] synonym: "skeletal system subdivision" EXACT [FMA:85544] xref: FMA:85544 xref: galen:ComplexSkeletalStructure xref: NCIT:C34076 xref: SCTID:118966000 xref: UMLS:C1519343 {source="ncithesaurus:Skeletal_System_Part"} is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: composed_primarily_of UBERON:0004765 ! skeletal element relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0001434 ! skeletal system [Term] id: UBERON:0000076 name: external ectoderm namespace: uberon def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [MGI:anna, MP:0012532] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "surface (external) ectoderm" EXACT [] synonym: "surface ectoderm" EXACT [MP:0012532] xref: BTO:0006242 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EHDAA2:0001968 xref: EHDAA:1494 xref: EHDAA:350 xref: EHDAA:4784 xref: EHDAA:4790 xref: EHDAA:4796 xref: EHDAA:7860 xref: EMAPA:16096 xref: FMA:87656 xref: NCIT:C34309 xref: UMLS:C1515087 {source="ncithesaurus:Surface_Ectoderm"} xref: Wikipedia:External_ectoderm is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0000924 {source="EHDAA2"} ! ectoderm property_value: editor_note "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png xsd:anyURI property_value: RO:0002171 UBERON:0002346 property_value: UBPROP:0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" xsd:string [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure namespace: uberon def: "An anatomical structure that develops from the endoderm and the mesoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: develops_from UBERON:0000926 ! mesoderm property_value: IAO:0000232 "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" xsd:string [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure namespace: uberon def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: develops_from UBERON:0000926 ! mesoderm property_value: IAO:0000232 "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" xsd:string [Term] id: UBERON:0000085 name: morula namespace: uberon def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [MP:0012130] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "morula (2-16 cells)" RELATED [EHDAA2:0000005] xref: BTO:0001508 xref: EHDAA2:0000005 xref: FMA:292334 xref: GAID:1295 xref: MESH:D009028 xref: NCIT:C34212 xref: SCTID:361474003 xref: UMLS:C0026573 {source="ncithesaurus:Morula"} xref: Wikipedia:Morula is_a: UBERON:0000922 ! embryo relationship: existence_ends_during UBERON:0000107 ! cleavage stage relationship: existence_starts_during UBERON:0000107 ! cleavage stage relationship: has_part CL:0000353 ! blastoderm cell relationship: part_of UBERON:0004716 {source="EHDAA2"} ! conceptus relationship: surrounded_by UBERON:0000086 ! zona pellucida property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png xsd:anyURI property_value: UBPROP:0000012 "EHDAA2 has embryo starting later" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0000086 name: zona pellucida namespace: uberon def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "oolemma" RELATED [BTO:0003135] synonym: "pellucid zone" RELATED [BTO:0003135] synonym: "striated membrane" RELATED [BTO:0003135] synonym: "vitelline envelope" RELATED [] synonym: "vitelline membrane" RELATED [] synonym: "zona pellucida - vitelline membrane" BROAD [VHOG:0000720] synonym: "zona radiata" RELATED [BTO:0003135] synonym: "zona striata" RELATED [BTO:0003135] xref: BTO:0003135 xref: EHDAA2:0002220 xref: EHDAA:31 xref: EHDAA:62 xref: EMAPA:16035 xref: FMA:18674 xref: GAID:410 xref: MA:0001715 xref: MESH:D015044 xref: NCIT:C33896 xref: TAO:0001111 xref: UMLS:C0043519 {source="ncithesaurus:Zona_Pellucida"} xref: Wikipedia:Zona_pellucida xref: ZFA:0001111 is_a: UBERON:0005764 ! acellular membrane relationship: bounding_layer_of CL:0000023 ! oocyte relationship: has_part CHEBI:17089 ! glycoprotein relationship: part_of CL:0000023 ! oocyte relationship: part_of UBERON:0000992 ! ovary property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000720", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000087 name: inner cell mass namespace: uberon def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." [ISBN:0-683-40008-8, MGI:pvb] subset: early_development subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "early embryoblast" RELATED [FMA:86557] synonym: "embryoblast" RELATED [] synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED OMO:0003011 [Wikipedia:Inner_cell_mass] synonym: "ICM" RELATED [VHOG:0000742] synonym: "pluriblast" RELATED [] xref: EFO:0000547 xref: EHDAA2:0000830 xref: EHDAA:40 xref: EMAPA:16041 xref: FMA:86557 xref: NCIT:C13740 xref: SCTID:361456007 xref: UMLS:C1283994 {source="ncithesaurus:Inner_Cell_Mass"} xref: VHOG:0000742 xref: Wikipedia:Inner_cell_mass is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000358 {source="Wikipedia"} ! blastocyst relationship: surrounded_by UBERON:0000088 {source="Wikipedia"} ! trophoblast property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI property_value: UBPROP:0000001 "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass]" xsd:string [Term] id: UBERON:0000088 name: trophoblast namespace: uberon def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031] comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] subset: early_development subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "massa cellularis externa" RELATED OMO:0003011 [Wikipedia:Trophoblast] synonym: "trophoblast layer" EXACT [MP:0005031] synonym: "trophoblastus" RELATED OMO:0003011 [Wikipedia:Trophoblast] synonym: "trophoderm" RELATED [BTO:0001079] xref: BTO:0001079 xref: CALOHA:TS-1070 xref: EV:0100120 xref: FMA:83029 xref: GAID:1152 xref: MESH:D014327 xref: NCIT:C93292 xref: SCTID:362839005 xref: UMLS:C0041178 {source="ncithesaurus:Trophoblast"} xref: Wikipedia:Trophoblast is_a: UBERON:0002050 ! embryonic structure relationship: composed_primarily_of CL:0000351 ! trophoblast cell relationship: develops_from UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! trophectoderm relationship: part_of UBERON:0000358 ! blastocyst property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI property_value: UBPROP:0000001 "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" xsd:string {date_retrieved="2012-08-23", external_class="MP:0005031", external_class_label="trophoblast layer", ontology="MP", source="ISBN:0-683-40008-8"} property_value: UBPROP:0000007 "trophoblastic" xsd:string property_value: UBPROP:0000011 "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" xsd:string {source="PMID:19829370"} [Term] id: UBERON:0000091 name: bilaminar disc namespace: uberon def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [MP:0003886] subset: early_development subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bilaminar disk" RELATED [Wikipedia:Bilaminar_disc] synonym: "bilaminary embryonic disc" EXACT [] synonym: "bilaminary germ disc" EXACT [ISBN:9780878932504] synonym: "embryonic disc" BROAD [MP:0003886] synonym: "embryonic shield" BROAD [MP:0003886] synonym: "germinal disc" BROAD [MP:0003886] synonym: "germinal disk" BROAD [MP:0003886] xref: FMA:293863 xref: NCIT:C34112 xref: UMLS:C1283997 {source="ncithesaurus:Bilaminar_Embryonic_Disc"} xref: Wikipedia:Bilaminar_disc is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000087 {source="Wikipedia"} ! inner cell mass property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png xsd:anyURI [Term] id: UBERON:0000092 name: post-embryonic stage namespace: uberon def: "Stage succeeding embryo, including mature structure." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "post-hatching stage" NARROW [] synonym: "postembryonic" RELATED [] synonym: "postembryonic stage" EXACT [] xref: BilaDO:0000003 xref: OGES:000010 xref: OGES:000014 xref: OGES:000024 xref: SsalDv:0000038 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000022 xref: WBls:0000093 xref: WBls:0000103 is_a: UBERON:0000105 ! life cycle stage relationship: preceded_by UBERON:0000068 ! embryo stage relationship: simultaneous_with GO:0009791 ! post-embryonic development property_value: seeAlso https://github.com/obophenotype/uberon/issues/344 xsd:anyURI property_value: UBPROP:0000008 "In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)" xsd:string [Term] id: UBERON:0000094 name: membrane organ namespace: uberon def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." [FMA:7145] subset: human_subset subset: mouse_subset synonym: "membrane" BROAD [] synonym: "membrane of organ" EXACT [] xref: FMA:7145 is_a: UBERON:0000062 ! organ relationship: composed_primarily_of UBERON:0011823 {source="FMA-def"} ! dense connective tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-07-30T05:19:13Z [Term] id: UBERON:0000095 name: cardiac neural crest namespace: uberon def: "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." [Wikipedia:Cardiac_neural_crest] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "cardiac neural crest complex" RELATED [Wikipedia:Cardiac_neural_crest] synonym: "complexus cristae neuralis cardiacus" RELATED [Wikipedia:Cardiac_neural_crest] xref: TAO:0002173 xref: Wikipedia:Cardiac_neural_crest xref: XAO:0004190 xref: ZFA:0001648 is_a: UBERON:0005291 ! embryonic tissue relationship: overlaps UBERON:0005428 {source="Wikipedia"} ! vagal neural crest relationship: part_of UBERON:0002342 ! neural crest property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 property_value: UBPROP:0000001 "A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]." xsd:string {source="DOI:10.1242/dev.091751"} property_value: UBPROP:0000012 "ZFA treats this as a subtype of NC." xsd:string {external_ontology="ZFA"} creation_date: 2009-07-30T07:57:38Z [Term] id: UBERON:0000101 name: lobe of lung namespace: uberon def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "lung lobe" EXACT [] synonym: "pulminory lobe" EXACT [] synonym: "pulmonary lobe" EXACT [FMA:7311] xref: EMAPA:36281 xref: FMA:7311 xref: galen:LobeOfLung xref: MA:0003098 xref: NCIT:C34021 xref: SCTID:245524004 xref: UMLS:C0225752 {source="ncithesaurus:Lung_Lobe"} is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0000102 name: lung vasculature namespace: uberon def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [GOC:GO] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "lung vascular network" EXACT [OBOL:automatic] synonym: "pulmonary vasculature" EXACT [FMA:73750] synonym: "vascular network of lung" EXACT [OBOL:automatic] synonym: "vasculature of lung" EXACT [OBOL:automatic] xref: FMA:73750 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0000104 name: life cycle namespace: uberon def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "entire life cycle" EXACT [] synonym: "entire lifespan" EXACT [] synonym: "life" EXACT [] synonym: "lifespan" EXACT [] xref: AcarDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BtauDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FBdv:00000000 xref: FcatDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ncithesaurus:Life xref: OanaDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000011 xref: PpanDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: UBERON:0000000 ! processual entity relationship: ends_with UBERON:0000071 ! death stage relationship: has_part UBERON:0000105 ! life cycle stage relationship: starts_with UBERON:0000106 {gci_relation="in_taxon", gci_filler="NCBITaxon:33208"} ! zygote stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: seeAlso https://github.com/obophenotype/uberon/issues/532 xsd:anyURI [Term] id: UBERON:0000105 name: life cycle stage namespace: uberon def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: efo_slim subset: human_subset subset: mouse_subset subset: upper_level synonym: "developmental stage" NARROW [] synonym: "stage" NARROW [] xref: AcarDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BILS:0000105 xref: BtauDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0000399 xref: FBdv:00007012 xref: FcatDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FMA:24120 xref: GgalDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MESH:D008018 xref: MmulDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ncithesaurus:Developmental_Stage xref: OanaDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PdumDv:0000090 xref: PpanDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000002 xref: XAO:1000000 xref: ZFS:0000000 xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity relationship: part_of UBERON:0000104 ! life cycle property_value: editor_note "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000012 "the WBls class 'all stages' belongs here as it is the superclass of other WBls stages" xsd:string property_value: UBPROP:0000012 "we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage" xsd:string [Term] id: UBERON:0000106 name: zygote stage namespace: uberon def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "1-cell stage" EXACT [] synonym: "fertilized egg stage" EXACT [BTO:0000854] synonym: "fertilized egg stage" RELATED [] synonym: "one cell stage" EXACT [] synonym: "one-cell stage" RELATED [VHOG:0000745] synonym: "zygote" RELATED [VHOG:0000745] synonym: "zygotum" RELATED OMO:0003011 [Wikipedia:Zygote] xref: BilaDO:0000005 xref: BILS:0000106 xref: ChirDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001322 xref: EHDAA:27 xref: FBdv:00005288 xref: HsapDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: IDOMAL:0000302 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: MmusDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: NCIT:C12601 xref: OariDv:0000009 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PdumDv:0000100 xref: RnorDv:0000048 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000087 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: VHOG:0000745 xref: Wikipedia:Zygote xref: XAO:1000001 xref: ZFS:0000001 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: seeAlso EMAPA:16033 relationship: starts UBERON:0000104 ! life cycle property_value: UBPROP:0000003 "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000745", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000107 name: cleavage stage namespace: uberon def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)] subset: efo_slim subset: human_subset subset: mouse_subset xref: BilaDO:0000006 xref: BILS:0000107 xref: ChirDv:0000004 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001290 xref: FBdv:00000054 xref: GgalDv:0000064 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000005 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MESH:D002970 xref: MmusDv:0000004 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000010 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000015 xref: OGES:000020 xref: PdumDv:0000200 xref: RnorDv:0000049 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000004 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000088 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Cleavage_(embryo) xref: XAO:1000004 xref: ZFS:0000046 is_a: UBERON:0000105 ! life cycle stage intersection_of: UBERON:0000105 ! life cycle stage intersection_of: simultaneous_with GO:0040016 ! embryonic cleavage relationship: immediately_preceded_by UBERON:0000106 ! zygote stage relationship: part_of UBERON:0000068 ! embryo stage relationship: simultaneous_with GO:0040016 ! embryonic cleavage [Term] id: UBERON:0000108 name: blastula stage namespace: uberon def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] subset: efo_slim subset: human_subset subset: mouse_subset xref: BilaDO:0000007 xref: BILS:0000108 xref: ChirDv:0000010 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001282 xref: GgalDv:0000091 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000006 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000025 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000003 xref: OGES:000016 xref: OGES:000021 xref: RnorDv:0000054 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000012 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000089 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000005 xref: Wikipedia:Blastula xref: XAO:1000003 xref: ZFS:0000045 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000107 ! cleavage stage property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png xsd:anyURI [Term] id: UBERON:0000109 name: gastrula stage namespace: uberon def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "blastocystis trilaminaris stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastocyst stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastoderm stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar disk stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar germ stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar stage" RELATED [https://orcid.org/0000-0002-6601-2165] xref: BilaDO:0000008 xref: BILS:0000109 xref: ChirDv:0000011 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001296 xref: FBdv:00005317 xref: GgalDv:0000092 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000010 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000013 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000026 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000004 xref: OGES:000019 xref: RnorDv:0000005 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000016 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000090 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000010 xref: XAO:1000005 xref: ZFS:0000047 is_a: UBERON:0000105 ! life cycle stage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000108 {source="BILS"} ! blastula stage relationship: simultaneous_with GO:0007369 ! gastrulation [Term] id: UBERON:0000110 name: neurula stage namespace: uberon def: "A chordate developmental stage defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841] subset: human_subset subset: mouse_subset xref: BilaDO:0000009 xref: BILS:0000110 xref: ChirDv:0000012 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000093 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000012 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000017 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000027 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000007 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000091 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: XAO:1000006 is_a: UBERON:0000105 ! life cycle stage relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000109 ! gastrula stage relationship: simultaneous_with GO:0001841 ! neural tube formation property_value: RO:0002174 NCBITaxon:7955 property_value: seeAlso https://github.com/obophenotype/developmental-stage-ontologies/issues/84 xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/343 xsd:anyURI property_value: UBPROP:0000008 "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." xsd:string [Term] id: UBERON:0000111 name: organogenesis stage namespace: uberon def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis] subset: human_subset subset: mouse_subset synonym: "segmentation stage" RELATED [] xref: BilaDO:0000010 xref: BILS:0000111 xref: ChirDv:0000013 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000094 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000015 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000018 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000028 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000005 xref: OGES:000032 xref: RnorDv:0000055 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000022 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000086 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Organogenesis is_a: UBERON:0000105 ! life cycle stage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000110 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! neurula stage relationship: simultaneous_with GO:0048513 ! animal organ development property_value: seeAlso https://github.com/obophenotype/developmental-stage-ontologies/issues/84 xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/533 xsd:anyURI [Term] id: UBERON:0000114 name: lung connective tissue namespace: uberon def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "connective tissue of lung" EXACT [OBOL:automatic] synonym: "lung interstitial tissue" RELATED [MA:0001782] synonym: "lung interstitium" RELATED [] synonym: "pulmonary connective tissue" RELATED [EMAPA:35521] synonym: "pulmonary interstitial tissue" RELATED [] synonym: "pulmonary interstitium" EXACT [FMA:27533] xref: EMAPA:35521 xref: FMA:27533 xref: MA:0001782 xref: SCTID:201609008 is_a: UBERON:0003580 ! lower respiratory tract connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002048 ! lung relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: develops_from UBERON:0004883 ! lung mesenchyme relationship: part_of UBERON:0002048 ! lung relationship: transformation_of UBERON:0004883 ! lung mesenchyme property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" xsd:string [Term] id: UBERON:0000115 name: lung epithelium namespace: uberon def: "The epithelial layer of the lung." [MP:0006382] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "epithelial tissue of lung" EXACT [OBOL:automatic] synonym: "epithelium of lung" EXACT [OBOL:automatic] synonym: "lung epithelial tissue" EXACT [OBOL:automatic] synonym: "pulmonary epithelium" RELATED [BTO:0001653] xref: BTO:0001653 xref: EMAPA:32860 xref: MA:0001783 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002048 ! lung relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: develops_from UBERON:0001041 ! foregut relationship: part_of UBERON:0002048 ! lung property_value: UBPROP:0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" xsd:string [Term] id: UBERON:0000117 name: respiratory tube namespace: uberon def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [GO:0030323, http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "airway" RELATED [] synonym: "respiratory conducting tube" NARROW [MP:0004391] synonym: "segment of tracheobronchial tree" EXACT [FMA:12224] synonym: "segment of tracheobronchial tree" NARROW [FMA:12224] synonym: "tracheobronchial tree segment" NARROW [FMA:12224] xref: EMAPA:37946 {source="MA:th"} xref: FMA:12224 is_a: UBERON:0000025 ! tube intersection_of: UBERON:0000025 ! tube intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: has_part UBERON:0000483 ! epithelium relationship: part_of UBERON:0000065 ! respiratory tract property_value: UBPROP:0000012 "in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class)" xsd:string {external_ontology="GO"} [Term] id: UBERON:0000118 name: lung bud namespace: uberon def: "Structure derived from foregut that becomes a lung[GO]." [GO:0060431, Wikipedia:Respiratory_bud] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "gemma pulmonalis" RELATED OMO:0003011 [Wikipedia:Lung_buds] synonym: "gemma respiratoria" RELATED OMO:0003011 [Wikipedia:Lung_buds] synonym: "lung bud" RELATED OMO:0003004 [] synonym: "primary lung bud" RELATED [GO:0060572] synonym: "respiratory diverticulum" RELATED [Wikipedia:Lung_buds] xref: BTO:0001643 xref: EHDAA2:0004089 xref: NCIT:C34260 xref: NCIT:C34282 xref: SCTID:361427007 xref: UMLS:C1514420 {source="ncithesaurus:Primary_Bronchial_Bud"} xref: UMLS:C1514897 {source="ncithesaurus:Respiratory_Diverticulum"} xref: Wikipedia:Respiratory_bud is_a: UBERON:0005153 {source="GO:0060441"} ! epithelial bud relationship: adjacent_to UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: develops_from UBERON:0005597 ! lung primordium relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium property_value: editor_note "clarify successors - include bronchi?" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png xsd:anyURI [Term] id: UBERON:0000122 name: neuron projection bundle namespace: uberon alt_id: UBERON:0005163 def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [CARO:0001001, FBbt:00005099, FBC:DOS] subset: human_subset subset: mouse_subset synonym: "funiculus" EXACT [] synonym: "nerve fiber bundle" EXACT [FBbt:00005099] synonym: "neural fiber bundle" EXACT [] xref: CARO:0001001 xref: FBbt:00005099 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: NLX:147821 is_a: UBERON:0005162 ! multi cell part structure relationship: has_part GO:0043005 ! neuron projection relationship: part_of UBERON:0001016 ! nervous system [Term] id: UBERON:0000125 name: neural nucleus namespace: uberon def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." [NLX:28443] subset: cumbo subset: human_subset subset: mouse_subset synonym: "nervous system nucleus" EXACT [] synonym: "neuraxis nucleus" EXACT [FMA:83686] synonym: "neuronal nucleus" EXACT [AEO:0000136] synonym: "nucleus" BROAD [] synonym: "nucleus of CNS" EXACT [NLX:28443] synonym: "nucleus of neuraxis" RELATED [] xref: AEO:0000136 xref: FMA:83686 xref: NCIT:C13197 xref: NLX:28443 xref: Wikipedia:Nucleus_(neuroanatomy) is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: composed_primarily_of UBERON:0002020 ! gray matter relationship: in_taxon NCBITaxon:7711 {notes="we limit this structure by definition to chordate and vertebrate nervous systems"} ! Chordata property_value: UBPROP:0000001 "Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]." xsd:string {source="GO_REF:0000021"} property_value: UBPROP:0000012 "Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate." xsd:string [Term] id: UBERON:0000126 name: cranial nerve nucleus namespace: uberon def: "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." [NLX:28532] subset: human_subset subset: mouse_subset synonym: "cranial neural nucleus" EXACT [FMA:54501] synonym: "nucleus nervi cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_nerve_nucleus] synonym: "nucleus of cranial nerve" EXACT [] xref: EMAPA:37066 {source="MA:th"} xref: FMA:54501 xref: NLX:28532 xref: SCTID:280160003 xref: Wikipedia:Cranial_nerve_nucleus is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve relationship: extends_fibers_into UBERON:0001785 ! cranial nerve relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png xsd:anyURI [Term] id: UBERON:0000153 name: anterior region of body namespace: uberon subset: human_subset subset: mouse_subset is_a: UBERON:0000475 ! organism subdivision disjoint_from: UBERON:0000154 {source="lexical"} ! posterior region of body relationship: anterior_to UBERON:0000154 ! posterior region of body relationship: in_taxon NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0000154 name: posterior region of body namespace: uberon subset: human_subset subset: mouse_subset is_a: UBERON:0000475 ! organism subdivision relationship: in_taxon NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0000158 name: membranous layer namespace: uberon subset: human_subset subset: mouse_subset synonym: "membrane" BROAD [] synonym: "membranous organ component" EXACT [FMA:82500] xref: FMA:30322 xref: FMA:82500 xref: MESH:D008566 xref: NCIT:C12749 is_a: UBERON:0004923 ! organ component layer relationship: bounding_layer_of UBERON:0000064 ! organ part property_value: UBPROP:0000001 "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures." xsd:string {source="ncithesaurus:Membrane"} [Term] id: UBERON:0000159 name: anal canal namespace: uberon def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "anal canal" EXACT [] synonym: "anal canal viewed anatomically" EXACT [] synonym: "anal pad" RELATED [] synonym: "anatomical anal canal" EXACT [] synonym: "anus" RELATED [] synonym: "canalis analis" RELATED OMO:0003011 [BTO:0001978, Wikipedia:Anal_canal] synonym: "cloaca" RELATED [] synonym: "cloacal chamber" RELATED [] synonym: "mesenteron" RELATED [] synonym: "pars analis recti" RELATED [BTO:0001978] xref: BTO:0001978 xref: CALOHA:TS-2160 xref: EMAPA:18256 xref: FMA:15703 xref: galen:AnalCanal xref: MA:0000330 xref: MESH:D001003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C12375 xref: SCTID:245438008 xref: UMLS:C0227411 {source="ncithesaurus:Anal_Canal"} xref: Wikipedia:Anal_canal is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0001988 ! feces relationship: continuous_with UBERON:0001052 ! rectum relationship: continuous_with UBERON:0001245 ! anus relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001353 ! anal region property_value: editor_note "requires alignment with EHDAA2 and complete developmental relationships" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000160 name: intestine namespace: uberon def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [GOC:GO, Wikipedia:Intestine] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bowel" EXACT [] synonym: "intestinal tract" RELATED [] xref: AAO:0000246 xref: ANISEED:1235303 xref: BSA:0000093 xref: BTO:0000648 xref: CALOHA:TS-0490 xref: EFO:0000834 xref: EMAPA:32874 xref: EV:0100071 xref: FMA:7199 xref: GAID:295 xref: galen:Intestine xref: MA:0000328 xref: MA:0001524 xref: MESH:D007422 xref: MIAA:0000043 xref: NCIT:C12736 xref: SCTID:256876008 xref: TAO:0001338 xref: UMLS:C0021853 {source="ncithesaurus:Intestine"} xref: VHOG:0000056 xref: WBbt:0005772 xref: Wikipedia:Intestine xref: XAO:0000129 xref: ZFA:0001338 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system property_value: editor_note "This class is probably too inclusive" xsd:string property_value: UBPROP:0000001 "Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000246", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000056", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "intestinal" xsd:string property_value: UBPROP:0000008 "In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type." xsd:string [Term] id: UBERON:0000161 name: orifice namespace: uberon def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." [FMA:3724] subset: human_subset subset: mouse_subset synonym: "anatomical orifice" EXACT [FMA:3724] synonym: "anatomical ostium" BROAD [FMA:3724] synonym: "hilum" NARROW [] synonym: "ostium" BROAD [] xref: FMA:3724 xref: SCTID:91837002 is_a: UBERON:0004111 ! anatomical conduit property_value: UBPROP:0000012 "in FMA, this is an anatomical conduit *space*, rather than anatomical conduit" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000162 name: cloaca namespace: uberon def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." [ISBN:0073040584, Wikipedia:Cloaca] subset: human_subset subset: mouse_subset synonym: "cloacal chamber" RELATED [AAO:0000095] synonym: "vent" RELATED [XAO:0000244] xref: AAO:0000095 xref: GAID:1206 xref: MESH:D002988 xref: NCIT:C34127 xref: SCTID:362857006 xref: SCTID:370631000 xref: UMLS:C0008987 {source="ncithesaurus:Cloaca"} xref: VHOG:0001186 xref: Wikipedia:Cloaca xref: XAO:0000244 xref: ZFA:0005781 is_a: UBERON:0013522 ! subdivision of tube relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001555 {source="ZFA"} ! digestive tract relationship: part_of UBERON:0004122 {source="AAO"} ! genitourinary system property_value: editor_note "adding df link to embryonic cloaca leads to a cycle in uberon-simple, as cloaca is a suberclass of embryonic cloaca" xsd:string property_value: RO:0002175 NCBITaxon:9369 {notes="most adult placentals have no trace of a cloaca. However, the tenrecs and golden moles, small placental mammals native to Africa, retain a cloaca as adults."} property_value: UBPROP:0000001 "A common passage for fecal, urinary, and reproductive discharge in most lower vertebrates as well as the terminal end of the hindgut before division into rectum, bladder, and genital primordia in mammalian embryos. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001186", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/cloaca"} property_value: UBPROP:0000001 "Anatomical structure which is the common receptacle for the alimentary canal, Wolffian ducts, oviducts, and the bladder.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000095", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "A cloaca is apparently a primitive vertebrate feature because it occurs in most primitive gnathostomes and persists in the embryos of almost all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001186", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.572", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "cloacal" xsd:string property_value: UBPROP:0000008 "Human beings only have an embryonic cloaca, which is split up into separate tracts during the development of the urinary and reproductive organs" xsd:string property_value: UBPROP:0000011 "hindgut endoderm and proctodeal ectoderm." xsd:string {source="WP"} [Term] id: UBERON:0000163 name: embryonic cloaca namespace: uberon def: "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [MP:0010115, Wikipedia:Cloaca_(embryology)] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cloaca" RELATED SENSU [] xref: EHDAA2:0000256 xref: EHDAA:4895 xref: EMAPA:27573 xref: Wikipedia:Cloaca_(embryology) is_a: UBERON:0000162 ! cloaca relationship: has_developmental_contribution_from UBERON:0003064 ! intermediate mesoderm relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001008 {source="EHDAA2"} ! renal system relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region property_value: IAO:0000232 "this class represents the embryonic form of the cloaca, as found in both mammals and non-mammals." xsd:string [Term] id: UBERON:0000165 name: mouth namespace: uberon def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, Wikipedia:Mouth] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adult mouth" NARROW [] synonym: "cavital oralis" RELATED OMO:0003011 [Wikipedia:Mouth] synonym: "cavitas oris" RELATED [BTO:0001090] synonym: "cavum oris" RELATED [BTO:0001090] synonym: "mouth cavity" RELATED [BTO:0001090] synonym: "oral region" RELATED [EHDAA2:0001326] synonym: "oral vestibule" RELATED [BTO:0001090] synonym: "regio oralis" EXACT OMO:0003011 [BTO:0004698, FMA:49184, FMA:TA] synonym: "rima oris" RELATED [BTO:0001090] synonym: "stoma" RELATED [] synonym: "stomatodaeum" RELATED [VHOG:0000812] synonym: "trophic apparatus" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "vestibule of mouth" RELATED [BTO:0001090] synonym: "vestibulum oris" RELATED [BTO:0001090] xref: AAO:0010355 xref: BTO:0001090 xref: BTO:0004698 xref: CALOHA:TS-1315 xref: EFO:0000825 xref: EHDAA2:0001326 xref: EHDAA:542 xref: EMAPA:16262 xref: FBbt:00003126 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:49184 xref: GAID:75 xref: galen:Mouth xref: http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg xref: MA:0000341 xref: MA:0002474 xref: MAT:0000038 xref: MESH:D009055 xref: MIAA:0000038 xref: SCTID:21082005 xref: TADS:0000040 xref: TAO:0000547 xref: TAO:0000590 xref: TGMA:0000131 xref: VHOG:0000280 xref: VHOG:0000812 xref: Wikipedia:Mouth xref: XAO:0003029 xref: ZFA:0000547 xref: ZFA:0000590 is_a: UBERON:0004921 {notes="the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts"} ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: proximalmost_part_of UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0035804 ! future mouth relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: proximalmost_part_of UBERON:0001555 ! digestive tract property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/661 xsd:anyURI property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "oral" xsd:string property_value: UBPROP:0000011 "some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives" xsd:string property_value: UBPROP:0000012 "in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000166 name: oral opening namespace: uberon def: "The orifice that connects the mouth to the exterior of the body." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "mouth" RELATED INCONSISTENT [] synonym: "oral fissure" EXACT [FMA:59806] synonym: "oral orifice" EXACT [FMA:59806] synonym: "oral part of face" RELATED [] xref: FMA:59806 is_a: UBERON:0000161 {source="FMA"} ! orifice relationship: overlaps UBERON:0001004 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! respiratory system relationship: part_of UBERON:0000165 ! mouth property_value: UBPROP:0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000280", ontology="VHOG", source="DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000167 name: oral cavity namespace: uberon def: "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bucca" RELATED [] synonym: "buccal cavity" EXACT [FMA:20292, ISBN:0073040584] synonym: "cavity of mouth" EXACT [] xref: AAO:0000053 xref: AAO:0000960 xref: BSA:0000107 xref: CALOHA:TS-1315 xref: EFO:0001975 xref: EHDAA2:0001324 xref: EHDAA:6970 xref: EMAPA:17411 xref: EMAPA:18399 xref: EV:0100057 xref: FMA:20292 xref: HAO:0000669 xref: MESH:D009055 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C12421 xref: SCTID:181220002 xref: TAO:0001027 xref: TGMA:0000102 xref: UMLS:C0226896 {source="ncithesaurus:Oral_Cavity"} xref: VHOG:0000188 xref: WBbt:0005255 xref: XAO:0000126 xref: ZFA:0001027 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0000464 ! anatomical space intersection_of: luminal_space_of UBERON:0000165 ! mouth relationship: contributes_to_morphology_of UBERON:0000165 ! mouth relationship: luminal_space_of UBERON:0000165 ! mouth relationship: part_of UBERON:0000165 ! mouth property_value: UBPROP:0000001 "Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000960", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000188", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/oral+cavity"} property_value: UBPROP:0000003 "Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000188", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.32", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000168 name: proximal-distal subdivision of colon namespace: uberon def: "A section dividing a colon along a proximal-distal axis." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: non_informative synonym: "segment of colon" RELATED [FMA:222905] xref: FMA:222905 is_a: UBERON:0004921 {order="4", source="cjm"} ! subdivision of digestive tract intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon relationship: subdivision_of UBERON:0001155 ! colon [Term] id: UBERON:0000170 name: pair of lungs namespace: uberon def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "lungs" EXACT [] synonym: "lungs pair" EXACT [] synonym: "pulmones" EXACT OMO:0003011 [FMA:68877, FMA:TA] synonym: "set of lungs" EXACT [] xref: FMA:68877 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: has_member UBERON:0002167 ! right lung intersection_of: has_member UBERON:0002168 ! left lung relationship: has_member UBERON:0002167 ! right lung relationship: has_member UBERON:0002167 {cardinality="1"} ! right lung relationship: has_member UBERON:0002168 ! left lung relationship: has_member UBERON:0002168 {cardinality="1"} ! left lung relationship: located_in UBERON:0002224 ! thoracic cavity relationship: part_of UBERON:0001558 {source="FMA-abduced"} ! lower respiratory tract property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000171 name: respiration organ namespace: uberon def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [GO:0007585] subset: functional_classification subset: human_subset subset: mouse_subset subset: organ_slim synonym: "apparatus respiratorius organ" EXACT [OBOL:automatic] synonym: "breathing organ" EXACT [] synonym: "gas exchange organ" RELATED [] synonym: "organ of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "organ of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory organ" EXACT [] synonym: "respiratory system organ" EXACT [OBOL:automatic] xref: SCTID:272626006 xref: SPD:0000428 xref: TGMA:0001247 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0000174 name: excreta namespace: uberon alt_id: UBERON:0000324 alt_id: UBERON:0007550 def: "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." [GO:0007588, http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "excreted substance" EXACT [] synonym: "excretion" RELATED [BTO:0000491] synonym: "portion of excreted substance" EXACT [FMA:9674] synonym: "waste substance" EXACT [AEO:0000184] xref: AEO:0000184 xref: BTO:0000491 xref: EHDAA2_RETIRED:0003184 xref: ENVO:02000022 xref: FMA:9674 xref: galen:Excretion is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: output_of GO:0007588 ! excretion relationship: output_of GO:0007588 ! excretion [Term] id: UBERON:0000178 name: blood namespace: uberon def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "portion of blood" EXACT [] synonym: "vertebrate blood" EXACT [] synonym: "whole blood" RELATED [BTO:0000089] xref: AAO:0000046 xref: BTO:0000089 xref: CALOHA:TS-0079 xref: EFO:0000296 xref: EHDAA2:0000176 xref: EHDAA:418 xref: EMAPA:16332 xref: ENVO:02000027 xref: EV:0100047 xref: FMA:9670 xref: GAID:965 xref: galen:Blood xref: MA:0000059 xref: MESH:D001769 xref: MIAA:0000315 xref: NCIT:C12434 xref: TAO:0000007 xref: UMLS:C0005767 {source="ncithesaurus:Blood"} xref: VHOG:0000224 xref: Wikipedia:Blood xref: XAO:0000124 xref: ZFA:0000007 is_a: UBERON:0000179 ! haemolymphatic fluid relationship: develops_from UBERON:0000922 ! embryo relationship: develops_from UBERON:0006596 ! presumptive blood relationship: has_part CL:0000232 {source="CL:tm"} ! erythrocyte relationship: has_part UBERON:0001969 ! blood plasma relationship: immediate_transformation_of UBERON:0006596 {source="Bgee:AN"} ! presumptive blood relationship: located_in UBERON:0002049 {source="https://github.com/obophenotype/uberon/issues/1330"} ! vasculature relationship: part_of UBERON:0002390 ! hematopoietic system property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan property_value: IAO:0000232 "This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000007", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO"} property_value: UBPROP:0000003 "Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000224", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual review of cell and developmental biology (2006) ", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000179 name: haemolymphatic fluid namespace: uberon def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "blood or blood analog" RELATED [] synonym: "circulating fluid" RELATED [] xref: CARO:0000081 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: part_of UBERON:0002193 ! hemolymphoid system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0002193 ! hemolymphoid system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-08T04:38:19Z [Term] id: UBERON:0000209 name: tetrapod frontal bone namespace: uberon def: "The bone forming the forehead and roof of the eye orbit." [ISBN:0-683-40008-8, MP:0000107, PMID:7914451, Wikipedia:Frontal_bone] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "frontal" NARROW [AAO:0000206] synonym: "frontal bone" NARROW SENSU [FMA:52734, MA:0001466] synonym: "os frontal" NARROW SENSU [Wikipedia:Frontal_bone] synonym: "os frontale" RELATED OMO:0003011 [Wikipedia:Frontal_bone] xref: AAO:0000206 xref: EMAPA:19016 xref: FMA:52734 xref: GAID:226 xref: MA:0001466 xref: MESH:D005624 xref: NCIT:C32635 xref: SCTID:181793006 xref: UMLS:C0016732 {source="ncithesaurus:Frontal_Bone"} xref: VSAO:0000208 xref: Wikipedia:Frontal_bone is_a: UBERON:0002514 ! intramembranous bone is_a: UBERON:0008907 ! dermal bone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: connected_to UBERON:0001677 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! sphenoid bone relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! ethmoid bone relationship: overlaps UBERON:0001697 ! orbit of skull relationship: part_of UBERON:0003113 {source="cjm"} ! dermatocranium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "fused in humans, paired in other animals" xsd:string property_value: UBPROP:0000011 "In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993)." xsd:string [Term] id: UBERON:0000219 name: vertebral foramen of atlas namespace: uberon subset: human_subset subset: mouse_subset synonym: "vertebral foramen of cervical vertebra 1" EXACT [] xref: FMA:24293 xref: SCTID:281228008 xref: Wikipedia:Atlas_(anatomy)#Vertebral_foramen is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: part_of UBERON:0001092 ! vertebral bone 1 relationship: part_of UBERON:0001092 ! vertebral bone 1 [Term] id: UBERON:0000220 name: atlanto-occipital joint namespace: uberon def: "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." [Wikipedia:Atlanto-occipital_joint] subset: human_subset subset: mouse_subset synonym: "articulatio atlanto-occipitalis" EXACT [FMA:24939] synonym: "articulatio atlantooccipitalis" RELATED OMO:0003011 [Wikipedia:Atlanto-occipital_joint] synonym: "atlanto occipital joint" EXACT [] synonym: "atlantooccipital joint" EXACT [] synonym: "craniovertebral joint" EXACT [FMA:24939] synonym: "occipito atlantal joint" EXACT [] synonym: "occipito-atlantal joint" EXACT [] xref: FMA:24939 xref: MESH:D001269 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C32158 xref: ncithesaurus:Atlanto-occipital_Joint-Atlanto xref: SCTID:361831006 xref: UMLS:C0004169 {source="ncithesaurus:Atlanto-occipital_Joint"} xref: Wikipedia:Atlanto-occipital_joint is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002217 ! synovial joint intersection_of: connects UBERON:0001092 ! vertebral bone 1 intersection_of: connects UBERON:0001676 ! occipital bone relationship: connects UBERON:0001092 ! vertebral bone 1 relationship: connects UBERON:0001676 ! occipital bone relationship: in_lateral_side_of UBERON:0006072 {source="FMA-abduced-lr"} ! cervical region of vertebral column relationship: part_of UBERON:0006072 ! cervical region of vertebral column property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png xsd:anyURI [Term] id: UBERON:0000304 name: tendon sheath namespace: uberon def: "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." [Wikipedia:Tendon_sheath] subset: human_subset subset: mouse_subset synonym: "synovial tendon sheath" EXACT [FMA:45087] synonym: "vagina tendinis" RELATED OMO:0003011 [Wikipedia:Tendon_sheath] xref: BTO:0000051 xref: FMA:45087 xref: FMA:76715 xref: NCIT:C96299 xref: SCTID:361885006 xref: UMLS:C0224856 {source="ncithesaurus:Tendon_Sheath"} xref: Wikipedia:Tendon_sheath is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: bounding_layer_of UBERON:0000043 ! tendon relationship: bounding_layer_of UBERON:0000043 ! tendon relationship: has_part UBERON:0011233 ! synovial membrane of synovial tendon sheath relationship: has_part UBERON:0011234 ! fibrous membrane of synovial tendon sheath relationship: part_of UBERON:0000043 ! tendon property_value: editor_note "TODO - add layer relations. 'tendon sheath' GAT in FMA." xsd:string [Term] id: UBERON:0000307 name: blastula namespace: uberon alt_id: UBERON:0007011 def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] subset: human_subset subset: inconsistent_with_fma subset: mouse_subset synonym: "blastosphere" RELATED [Wikipedia:Blastula] synonym: "blastula embryo" EXACT [BILA:0000059] xref: BILA:0000059 xref: BTO:0000128 xref: GAID:1294 xref: MESH:D036703 xref: OGEM:000006 xref: Wikipedia:Blastula is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage relationship: develops_from UBERON:0007010 ! cleaving embryo relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png xsd:anyURI [Term] id: UBERON:0000317 name: colonic mucosa namespace: uberon alt_id: UBERON:0003347 alt_id: UBERON:0004981 def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "colon mucosa" EXACT [FMA:14984] synonym: "colon mucous membrane" EXACT [OBOL:automatic] synonym: "colonic mucosa" EXACT [] synonym: "colonic mucous membrane" EXACT [FMA:14984] synonym: "large bowel mucosa" EXACT [OBOL:automatic] synonym: "mucosa of colon" EXACT [FMA:14984] synonym: "mucosa of large bowel" EXACT [OBOL:automatic] xref: BTO:0000271 xref: CALOHA:TS-0164 xref: EFO:0003038 xref: EMAPA:27375 xref: FMA:14984 xref: FMA:85388 xref: MA:0003194 xref: SCTID:362157008 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000320 name: duodenal mucosa namespace: uberon alt_id: UBERON:0003348 def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "doudenal mucosa" EXACT [FMA:14942] synonym: "duodenal mucous membrane" EXACT [FMA:14942] synonym: "duodenum mucosa" RELATED [BTO:0000367] synonym: "mucosa of duodenum" EXACT [OBOL:automatic] synonym: "mucous membrane of duodenum" EXACT [OBOL:automatic] xref: BTO:0000367 xref: CALOHA:TS-0213 xref: EMAPA:27235 xref: FMA:14942 xref: MA:0003207 xref: SCTID:362146003 is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000325 name: gastric gland namespace: uberon def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." [MGI:anna] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim xref: BTO:0000503 xref: EMAPA:27181 xref: FMA:14919 is_a: UBERON:0002365 {source="cjm"} ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: part_of UBERON:0006924 {source="ISBN:0073040584"} ! stomach glandular epithelium [Term] id: UBERON:0000326 name: pancreatic juice namespace: uberon def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157] subset: human_subset subset: mouse_subset synonym: "pancreatic fluid" RELATED [] synonym: "pancreatic secretion" RELATED [] synonym: "succus pancreaticus" RELATED [BTO:0000504] xref: BTO:0000504 xref: CALOHA:TS-2235 xref: FMA:62973 xref: GAID:1166 xref: MESH:D010189 is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: produced_by UBERON:0001264 ! pancreas relationship: produced_by UBERON:0001264 ! pancreas [Term] id: UBERON:0000328 name: gut wall namespace: uberon def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "digestive tract wall" EXACT [] synonym: "wall of alimentary tract" RELATED [] synonym: "wall of digestive tract" EXACT [] synonym: "wall of gut" EXACT [FMA:45653] xref: BTO:0000547 xref: FMA:45653 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: IAO:0000232 "We model the digestive tract as consisting of two parts: the wall and the lumen." xsd:string [Term] id: UBERON:0000332 name: yellow bone marrow namespace: uberon def: "Bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow] subset: human_subset subset: mouse_subset synonym: "fat marrow" RELATED [BTO:0000635] synonym: "medulla ossium flava" EXACT OMO:0003011 [BTO:0000635] synonym: "yellow marrow" EXACT [BTO:0000635] xref: BTO:0000635 xref: FMA:74596 xref: SCTID:328639002 xref: SCTID:5023006 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: composed_primarily_of CL:0000136 ! adipocyte relationship: composed_primarily_of CL:0000136 ! adipocyte relationship: part_of UBERON:0007195 ! stroma of bone marrow [Term] id: UBERON:0000333 name: intestinal gland namespace: uberon def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: organ_slim synonym: "bowel mucosa gland" EXACT [OBOL:automatic] synonym: "bowel mucosa of organ gland" EXACT [OBOL:automatic] synonym: "bowel mucous membrane gland" EXACT [OBOL:automatic] synonym: "bowel organ mucosa gland" EXACT [OBOL:automatic] synonym: "gland of bowel mucosa" EXACT [OBOL:automatic] synonym: "gland of bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "gland of bowel mucous membrane" EXACT [OBOL:automatic] synonym: "gland of bowel organ mucosa" EXACT [OBOL:automatic] synonym: "gland of intestinal mucosa" EXACT [OBOL:automatic] synonym: "gland of intestine mucosa" EXACT [OBOL:automatic] synonym: "gland of intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "gland of intestine mucous membrane" EXACT [OBOL:automatic] synonym: "gland of intestine organ mucosa" EXACT [OBOL:automatic] synonym: "gland of mucosa of bowel" EXACT [OBOL:automatic] synonym: "gland of mucosa of intestine" EXACT [OBOL:automatic] synonym: "gland of mucosa of organ of bowel" EXACT [OBOL:automatic] synonym: "gland of mucosa of organ of intestine" EXACT [OBOL:automatic] synonym: "gland of mucous membrane of bowel" EXACT [OBOL:automatic] synonym: "gland of mucous membrane of intestine" EXACT [OBOL:automatic] synonym: "gland of organ mucosa of bowel" EXACT [OBOL:automatic] synonym: "gland of organ mucosa of intestine" EXACT [OBOL:automatic] synonym: "glandula intestinalis" EXACT [FMA:15052] synonym: "glandulae intestinales" RELATED [] synonym: "intestinal mucosa gland" EXACT [OBOL:automatic] synonym: "intestine mucosa gland" EXACT [OBOL:automatic] synonym: "intestine mucosa of organ gland" EXACT [OBOL:automatic] synonym: "intestine mucous membrane gland" EXACT [OBOL:automatic] synonym: "intestine organ mucosa gland" EXACT [OBOL:automatic] synonym: "mucosa of bowel gland" EXACT [OBOL:automatic] synonym: "mucosa of intestine gland" EXACT [OBOL:automatic] synonym: "mucosa of organ of bowel gland" EXACT [OBOL:automatic] synonym: "mucosa of organ of intestine gland" EXACT [OBOL:automatic] synonym: "mucous membrane of bowel gland" EXACT [OBOL:automatic] synonym: "mucous membrane of intestine gland" EXACT [OBOL:automatic] synonym: "organ mucosa of bowel gland" EXACT [OBOL:automatic] synonym: "organ mucosa of intestine gland" EXACT [OBOL:automatic] xref: BTO:0000640 xref: FMA:15052 xref: SCTID:266297002 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001242 ! intestinal mucosa relationship: part_of UBERON:0001242 ! intestinal mucosa property_value: UBPROP:0000012 "Note that some sources treat 'intestinal gland' as synonymous with crypts" xsd:string [Term] id: UBERON:0000344 name: mucosa namespace: uberon def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." [Wikipedia:Mucous_membrane] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "mucosa of organ" EXACT [FMA:85355] synonym: "mucosa of organ part" EXACT [FMA:85358] synonym: "mucosal region" EXACT [FMA:85358] synonym: "mucous membrane" EXACT [FMA:85355] synonym: "organ mucosa" EXACT [FMA:85355] synonym: "region of mucosa" RELATED [FMA:85358] synonym: "tunica mucosa" RELATED OMO:0003011 [BTO:0000886, Wikipedia:Mucous_membrane] xref: AEO:0000199 xref: BTO:0000886 xref: CALOHA:TS-2031 xref: EHDAA2_RETIRED:0003234 xref: EV:0100382 xref: FMA:85355 xref: FMA:85358 xref: GAID:297 xref: galen:Mucosa xref: MESH:D009092 xref: NCIT:C13166 xref: SCTID:361693009 xref: UMLS:C0026724 {source="ncithesaurus:Mucosa"} xref: Wikipedia:Mucous_membrane is_a: UBERON:0004923 ! organ component layer relationship: has_part UBERON:0000483 ! epithelium relationship: has_part UBERON:0002384 ! connective tissue relationship: in_taxon NCBITaxon:7711 ! Chordata property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png xsd:anyURI property_value: RO:0002171 UBERON:0000009 property_value: UBPROP:0000007 "mucosal" xsd:string property_value: UBPROP:0000012 "FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000353 name: parenchyma namespace: uberon def: "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." [Wikipedia:Parenchyma] subset: human_subset subset: mouse_subset xref: BTO:0000999 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: BTO:0001539 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EHDAA:3015 xref: EHDAA:3905 xref: EHDAA:3999 xref: EHDAA:4005 xref: EHDAA:6899 xref: EHDAA:6903 xref: EHDAA:6994 xref: EHDAA:8086 xref: EHDAA:9182 xref: EHDAA:9190 xref: EHDAA:9196 xref: EHDAA:9202 xref: FMA:45732 xref: NCIT:C74601 xref: UMLS:C0933845 {source="ncithesaurus:Parenchyma"} xref: Wikipedia:Parenchyma is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: capable_of GO:0032501 ! multicellular organismal process relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: UBPROP:0000007 "parenchymal" xsd:string property_value: UBPROP:0000011 "Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin" xsd:string {source="WP"} property_value: UBPROP:0000012 "the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000355 name: pharyngeal mucosa namespace: uberon alt_id: UBERON:0003344 def: "A mucosa that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mucosa of organ of pharynx" EXACT [OBOL:automatic] synonym: "mucosa of pharynx" EXACT [OBOL:automatic] synonym: "mucous membrane of pharynx" EXACT [FMA:55031, OBOL:automatic] synonym: "mucous membrane of the pharynx" RELATED [BTO:0001047] synonym: "organ mucosa of pharynx" EXACT [OBOL:automatic] synonym: "pharynx mucosa" EXACT [OBOL:automatic] synonym: "pharynx mucosa of organ" EXACT [OBOL:automatic] synonym: "pharynx mucous membrane" EXACT [OBOL:automatic] synonym: "pharynx organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa pharyngea" EXACT OMO:0003011 [FMA:55031, FMA:TA] synonym: "tunica mucosa pharyngis" EXACT [] xref: BTO:0001047 xref: EMAPA:26957 xref: FMA:55031 xref: MA:0003143 xref: SCTID:362121003 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0000358 name: blastocyst namespace: uberon def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [GO:0001824, Wikipedia:Blastocyst] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "blastocystis" RELATED OMO:0003011 [Wikipedia:Blastocyst] synonym: "blastula" RELATED [FMA:83041] xref: BTO:0001099 xref: CALOHA:TS-0076 xref: EFO:0000295 xref: EMAPA:36035 xref: EV:0100394 xref: FMA:83041 xref: GAID:1153 xref: MESH:D001755 xref: NCIT:C13739 xref: SCTID:308837009 xref: UMLS:C1281743 {source="ncithesaurus:Blastocyst"} xref: Wikipedia:Blastocyst is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000085 ! morula relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage relationship: has_part UBERON:0000087 ! inner cell mass relationship: has_part UBERON:0000088 ! trophoblast relationship: in_taxon NCBITaxon:32525 ! Theria relationship: part_of UBERON:0000307 ! blastula property_value: editor_note "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI [Term] id: UBERON:0000361 name: red bone marrow namespace: uberon def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow] subset: human_subset subset: mouse_subset synonym: "medulla ossium rubra" EXACT OMO:0003011 [BTO:0001160] synonym: "parenchyma of none marrow marrow" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "parenchymal red marrow" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "red marrow" EXACT [BTO:0001160] xref: BTO:0001160 xref: FMA:74595 xref: SCTID:328538003 xref: SCTID:75330005 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: composed_primarily_of CL:0000988 ! hematopoietic cell relationship: composed_primarily_of CL:0000988 ! hematopoietic cell relationship: part_of UBERON:0012429 ! hematopoietic tissue [Term] id: UBERON:0000371 name: syncytiotrophoblast namespace: uberon def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast] subset: human_subset subset: mouse_subset synonym: "syncitiotrophoblast" RELATED [] synonym: "syncitiotrophoblastus" RELATED OMO:0003011 [Wikipedia:Syncytiotrophoblast] synonym: "syncytial trophoblast" EXACT [FMA:83040] synonym: "syntrophoblast" RELATED [] synonym: "syntrophoblast layer" EXACT [ISBN:0073040584] xref: BTO:0001335 xref: EHDAA:129 xref: EHDAA:91 xref: EMAPA:16068 xref: FMA:83040 xref: NCIT:C33918 xref: SCTID:256965005 xref: UMLS:C1135936 {source="ncithesaurus:Syncytiotrophoblast"} xref: Wikipedia:Syncytiotrophoblast is_a: UBERON:0002050 {source="FMA"} ! embryonic structure relationship: composed_primarily_of CL:0000525 ! syncytiotrophoblast cell relationship: part_of UBERON:0004364 {source="EMAPA"} ! ectoplacental cone property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png xsd:anyURI [Term] id: UBERON:0000377 name: maxillary nerve namespace: uberon def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "maxillary division [V2]" EXACT [FMA:52724] synonym: "maxillary division [Vb]" EXACT [FMA:52724] synonym: "maxillary division of fifth cranial nerve" EXACT [FMA:52724] synonym: "maxillary division of trigeminal nerve (Vb; V2)" EXACT [FMA:52724] synonym: "maxillary nerve [V2]" EXACT [FMA:52724] synonym: "maxillary nerve [Vb]" EXACT [FMA:52724] synonym: "n. maxillaris" RELATED OMO:0003011 [Wikipedia:Maxillary_nerve] synonym: "nervus maxillaris" RELATED [BTO:0001378] synonym: "nervus maxillaris (Vb; V2)" EXACT [FMA:52724] synonym: "nervus maxillaris [v2]" EXACT OMO:0003011 [FMA:52724, FMA:TA] synonym: "nervus maxillaris [vb]" EXACT OMO:0003011 [FMA:52724, FMA:TA] synonym: "ramus maxillaris (ramus V2)" EXACT [AAO:0010670] synonym: "second division of fifth cranial nerve" EXACT [FMA:52724] synonym: "second division of trigeminal nerve" EXACT [FMA:52724] synonym: "trigeminal nerve maxillary division" RELATED [EMAPA:17799] synonym: "trigeminal V nerve maxillary division" EXACT [MA:0001103] xref: AAO:0010670 xref: BTO:0001378 xref: EHDAA2:0002087 xref: EMAPA:17799 xref: FMA:52724 xref: GAID:836 xref: MA:0001103 xref: MESH:D008442 xref: SCTID:280211001 xref: VHOG:0001346 xref: Wikipedia:Maxillary_nerve is_a: UBERON:0011779 ! nerve of head region relationship: branching_part_of UBERON:0001645 ! trigeminal nerve relationship: part_of UBERON:0001645 ! trigeminal nerve property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Medial ramus (sensory) of the trigeminal nerve.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000002 "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO"} [Term] id: UBERON:0000379 name: tracheal mucosa namespace: uberon def: "A mucosa that is part of a respiratory airway." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mucosa of organ of trachea" EXACT [OBOL:automatic] synonym: "mucosa of organ of windpipe" EXACT [OBOL:automatic] synonym: "mucosa of trachea" EXACT [OBOL:automatic] synonym: "mucosa of windpipe" EXACT [OBOL:automatic] synonym: "mucous membrane of trachea" EXACT [FMA:7471, OBOL:automatic] synonym: "mucous membrane of windpipe" EXACT [OBOL:automatic] synonym: "organ mucosa of trachea" EXACT [OBOL:automatic] synonym: "organ mucosa of windpipe" EXACT [OBOL:automatic] synonym: "trachea mucosa" EXACT [OBOL:automatic] synonym: "trachea mucosa of organ" EXACT [OBOL:automatic] synonym: "trachea mucous membrane" EXACT [OBOL:automatic] synonym: "trachea organ mucosa" EXACT [OBOL:automatic] synonym: "tracheal mucous membrane" EXACT [FMA:7471] synonym: "tunica mucosa (tracheae)" EXACT [FMA:7471] synonym: "tunica mucosa tracheae" EXACT OMO:0003011 [FMA:7471, FMA:TA] synonym: "windpipe mucosa" EXACT [OBOL:automatic] synonym: "windpipe mucosa of organ" EXACT [OBOL:automatic] synonym: "windpipe mucous membrane" EXACT [OBOL:automatic] synonym: "windpipe organ mucosa" EXACT [OBOL:automatic] xref: BTO:0001390 xref: FMA:7471 xref: SCTID:660006 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001005 ! respiratory airway relationship: part_of UBERON:0001005 ! respiratory airway [Term] id: UBERON:0000383 name: musculature of body namespace: uberon def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." [VSAO:0000033] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "muscle system" EXACT [] synonym: "muscle system of body" EXACT [] synonym: "muscular system" EXACT [FMA:72954] synonym: "musculature system" EXACT [BILA:0000088] synonym: "muskelsystem" RELATED [BTO:0001485] synonym: "set of all muscles" EXACT [FMA:72954] synonym: "set of muscles of body" EXACT [FMA:72954] synonym: "vertebrate muscular system" EXACT [BTO:0001369] xref: AAO:0000307 xref: BILA:0000088 xref: BTO:0001369 xref: BTO:0001485 xref: EFO:0000801 xref: FMA:72954 xref: MA:0002888 xref: MAT:0000025 xref: MIAA:0000025 xref: VSAO:0000033 xref: XAO:0004042 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: composed_primarily_of UBERON:0001015 ! musculature relationship: capable_of GO:0003012 ! muscle system process relationship: composed_primarily_of UBERON:0001015 ! musculature relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: editor_note "consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77" xsd:string property_value: RO:0002161 NCBITaxon:6040 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical system that consists of the muscles of the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000033", ontology="VSAO", source="VSAO:curator"} property_value: UBPROP:0000012 "we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA" xsd:string {external_ontology="MA"} [Term] id: UBERON:0000389 name: lens cortex namespace: uberon def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cortex of lens" EXACT [FMA:58970] xref: BTO:0001632 xref: CALOHA:TS-0542 xref: FMA:58970 xref: MESH:D007904 xref: SCTID:280626006 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000479 ! tissue intersection_of: surrounds UBERON:0000390 ! lens nucleus relationship: develops_from UBERON:0005614 ! lens anterior epithelium relationship: part_of UBERON:0000965 ! lens of camera-type eye relationship: surrounds UBERON:0000390 ! lens nucleus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000390 name: lens nucleus namespace: uberon def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "nucleus of lens" EXACT [FMA:58971] xref: BTO:0001633 xref: FMA:58971 xref: MESH:D007907 xref: SCTID:280628007 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: surrounded_by UBERON:0000389 ! lens cortex relationship: develops_from UBERON:0005614 ! lens anterior epithelium relationship: part_of UBERON:0000965 ! lens of camera-type eye relationship: surrounded_by UBERON:0000389 ! lens cortex property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000397 name: colonic epithelium namespace: uberon def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "colon epithelial tissue" EXACT [OBOL:automatic] synonym: "colon epithelium" EXACT [FMA:17302, OBOL:automatic] synonym: "epithelial tissue of colon" EXACT [OBOL:automatic] synonym: "epithelial tissue of large bowel" EXACT [OBOL:automatic] synonym: "epithelium of colon" EXACT [OBOL:automatic] synonym: "epithelium of large bowel" EXACT [OBOL:automatic] synonym: "large bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "large bowel epithelium" EXACT [OBOL:automatic] synonym: "posterior intestine epithelium" EXACT [ZFA:0005128] xref: BTO:0001709 xref: CALOHA:TS-0163 xref: EMAPA:18941 xref: FMA:17302 xref: MA:0003195 xref: SCTID:42978003 xref: TAO:0005128 xref: ZFA:0005128 is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Intestinal epithelium which lines the lumen of the posterior intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005128", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0000409 name: serous gland namespace: uberon def: "A gland in which the principal secretory cells are serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim xref: BTO:0001837 xref: EMAPA:37950 {source="MA:th"} xref: FMA:62889 xref: Wikipedia:Serous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: has_part CL:0000313 ! serous secreting cell relationship: has_part CL:0000313 ! serous secreting cell relationship: has_part UBERON:0013232 ! serous acinus relationship: produces UBERON:0007794 ! secretion of serous gland property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png xsd:anyURI property_value: UBPROP:0000001 "glands that secrete watery albuminous material that often contains enzymes[MP:0008052]." xsd:string {source="MP:0008052"} [Term] id: UBERON:0000410 name: bronchial mucosa namespace: uberon def: "A mucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bronchi mucosa" EXACT [OBOL:automatic] synonym: "bronchi mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchi mucous membrane" EXACT [OBOL:automatic] synonym: "bronchi organ mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchial trunk mucous membrane" EXACT [OBOL:automatic] synonym: "bronchial trunk organ mucosa" EXACT [OBOL:automatic] synonym: "bronchus mucosa" EXACT [OBOL:automatic] synonym: "bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "bronchus organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bronchi" EXACT [OBOL:automatic] synonym: "mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucosa of bronchus" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchi" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchi" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchus" EXACT [FMA:62652, OBOL:automatic] synonym: "organ mucosa of bronchi" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchus" EXACT [OBOL:automatic] synonym: "tunica mucosa bronchi" EXACT OMO:0003011 [FMA:62652, FMA:TA] xref: BTO:0001846 xref: FMA:62652 xref: SCTID:30802009 is_a: UBERON:0000379 ! tracheal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0000414 name: mucous gland namespace: uberon def: "A gland in which the principal secretory cells are mucus secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] subset: human_subset subset: mouse_subset subset: organ_slim synonym: "glandula mucosa" EXACT OMO:0003011 [Wikipedia:Mucous_gland] synonym: "muciparous gland" RELATED [BTO:0001979] synonym: "mucous secreting gland" RELATED [] synonym: "mucus gland" RELATED [] synonym: "mucus-secreting gland" RELATED [] xref: AAO:0010601 xref: BTO:0001979 xref: EMAPA:37913 {source="MA:th"} xref: FMA:62888 xref: Wikipedia:Mucous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: has_part CL:0000319 ! mucus secreting cell relationship: capable_of GO:0070254 ! mucus secretion relationship: has_part CL:0000319 ! mucus secreting cell relationship: produces UBERON:0000912 ! mucus property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png xsd:anyURI property_value: UBPROP:0000008 "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" xsd:string {scope="NCBITaxon:8292", source="ISBN:0073040584"} [Term] id: UBERON:0000415 name: artery wall namespace: uberon def: "An anatomical wall that is part of an artery [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arterial wall" EXACT [FMA:14155] synonym: "wall of artery" EXACT [FMA:14155] xref: BTO:0002009 xref: FMA:14155 xref: galen:ArterialWall is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0000440 name: trabecula namespace: uberon def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula] subset: grouping_class subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "trabeculae" EXACT OMO:0003004 [] xref: BTO:0002501 xref: FMA:85273 xref: Wikipedia:Trabecula is_a: UBERON:0000064 ! organ part relationship: has_part UBERON:0002384 ! connective tissue relationship: has_quality PATO:0001873 ! cylindrical property_value: UBPROP:0000007 "trabecular" xsd:string [Term] id: UBERON:0000456 name: secretion of exocrine gland namespace: uberon alt_id: UBERON:0006540 def: "A portion of organism substance that is produced by exocrine glands." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "bodily secretion" EXACT [MESH:D012634] synonym: "exocrine gland fluid" RELATED [] synonym: "exocrine gland fluid or secretion" RELATED [] synonym: "exocrine gland fluid/secretion" EXACT [MA:0002504] synonym: "exocrine gland secretion" RELATED [] synonym: "external secretion" RELATED [BTO:0002977] synonym: "secreted substance" EXACT [] synonym: "secretion" BROAD [FMA:9675] xref: AEO:0001005 xref: BTO:0002977 xref: BTO:0002979 xref: EMAPA:36535 xref: FMA:9675 xref: galen:Secretion xref: MA:0002504 xref: MESH:D012634 xref: NCIT:C34062 xref: UMLS:C1516992 {source="ncithesaurus:Exocrine_Gland_Fluid_or_Secretion"} is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0002365 ! exocrine gland relationship: produced_by UBERON:0002365 ! exocrine gland property_value: UBPROP:0000012 "BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions" xsd:string {external_ontology="BTO"} [Term] id: UBERON:0000463 name: organism substance namespace: uberon def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: pheno_slim subset: upper_level synonym: "body fluid or substance" EXACT [MA:0002450] synonym: "body substance" EXACT [FMA:9669] synonym: "organism substance" EXACT [CARO:0000004] synonym: "portion of body substance" EXACT [FMA:9669] synonym: "portion of organism substance" EXACT [ZFA:0001487] xref: AAO:0010839 xref: AEO:0000004 xref: BILA:0000004 xref: CALOHA:TS-2101 xref: CARO:0000004 xref: EHDAA2:0003004 xref: EMAPA:35178 xref: FBbt:00007019 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9669 xref: galen:BodySubstance xref: HAO:0000004 xref: MA:0002450 xref: NCIT:C13236 xref: SPD:0000008 xref: TAO:0001487 xref: TGMA:0001824 xref: VHOG:0001726 xref: XAO:0004001 xref: ZFA:0001487 is_a: UBERON:0000465 ! material anatomical entity relationship: has_quality PATO:0002198 ! quality of a substance relationship: part_of UBERON:0000468 {notes="this relationship may be too strong and may be weakened in future"} ! multicellular organism property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000464 name: anatomical space namespace: uberon def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "anatomical spaces" RELATED OMO:0003004 [ZFA:0001643] synonym: "lumen" BROAD [] synonym: "lumen space" EXACT [] synonym: "space" BROAD [] xref: AAO:0010110 xref: AEO:0000005 xref: BILA:0000005 xref: CARO:0000005 xref: EHDAA2:0003005 xref: FBbt:00007017 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:5897 xref: HAO:0000005 xref: NCIT:C94478 xref: TAO:0001668 xref: TGMA:0001825 xref: UMLS:C0524461 {source="ncithesaurus:Lumen_Space"} xref: VHOG:0001728 xref: XAO:0003190 xref: ZFA:0001643 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: surrounded_by UBERON:0000061 ! anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000465 name: material anatomical entity namespace: uberon def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level xref: AAO:0010264 xref: AEO:0000006 xref: BILA:0000006 xref: CARO:0000006 xref: EHDAA2:0003006 xref: FBbt:00007016 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67165 xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 is_a: BFO:0000040 ! material entity is_a: UBERON:0001062 ! anatomical entity disjoint_from: UBERON:0000466 ! immaterial anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000466 name: immaterial anatomical entity namespace: uberon def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "immaterial physical anatomical entity" EXACT [FMA:67112] xref: AAO:0010265 xref: AEO:0000007 xref: BILA:0000007 xref: CARO:0000007 xref: EHDAA2:0003007 xref: FBbt:00007015 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67112 xref: HAO:0000007 xref: TAO:0001835 xref: TGMA:0001827 xref: VHOG:0001727 is_a: BFO:0000141 ! immaterial entity is_a: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000467 name: anatomical system namespace: uberon def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011] subset: common_anatomy subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomical systems" RELATED OMO:0003004 [ZFA:0001439] synonym: "body system" EXACT [BIRNLEX:14] synonym: "connected anatomical system" EXACT [CARO:0000011] synonym: "organ system" EXACT [] synonym: "system" BROAD [GO:0048731] xref: AAO:0000007 xref: AEO:0000011 xref: BILA:0000011 xref: BIRNLEX:14 xref: BSA:0000049 xref: CALOHA:TS-2088 xref: CARO:0000011 xref: EHDAA2:0003011 xref: EHDAA:392 xref: EMAPA:16103 xref: EV:0100000 xref: FBbt:00004856 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7149 xref: galen:AnatomicalSystem xref: HAO:0000011 xref: IDOMAL:0002460 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: MA:0000003 xref: NCIT:C12919 xref: SCTID:278195005 xref: TAO:0001439 xref: TGMA:0001831 xref: UMLS:C0460002 {source="ncithesaurus:Organ_System"} xref: VHOG:0001725 xref: WBbt:0005746 xref: WBbt:0005763 xref: Wikipedia:Organ_system xref: XAO:0003002 xref: ZFA:0001439 is_a: UBERON:0000061 ! anatomical structure relationship: existence_starts_during_or_after UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! organogenesis stage relationship: has_part UBERON:0000062 ! organ relationship: part_of UBERON:0000468 ! multicellular organism relationship: seeAlso EHDAA2:0001330 property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000468 name: multicellular organism namespace: uberon def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, http://orcid.org/0000-0001-9114-8737, Wikipedia:Multi-cellular_organism] subset: common_anatomy subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "body" RELATED [AEO:0000103, BIRNLEX:18, FMA:256135, NCIT:C13041] synonym: "Koerper" RELATED [BTO:0001489] synonym: "multi-cellular organism" EXACT [CARO:0000012] synonym: "organism" BROAD [FBbt:00000001, VHOG:0000671, WBbt:0007833] synonym: "whole body" RELATED [BTO:0001489] synonym: "whole organism" RELATED [FBbt:00000001] xref: AAO:0010026 xref: AEO:0000191 xref: BILA:0000012 xref: BIRNLEX:18 xref: BSA:0000038 xref: BTO:0000042 xref: CARO:0000012 xref: EFO:0002906 xref: EHDAA2:0003103 xref: EHDAA2:0003191 xref: EHDAA:1 xref: EMAPA:25765 xref: EV:0100016 xref: FBbt:00000001 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:256135 xref: galen:Organism xref: HAO:0000012 xref: NCIT:C13041 xref: ncithesaurus:Whole_Organism xref: SCTID:243928005 xref: TADS:0000001 xref: TAO:0001094 xref: TGMA:0001832 xref: VHOG:0000671 xref: WBbt:0007833 xref: Wikipedia:Multi-cellular_organism xref: XAO:0003004 xref: ZFA:0001094 is_a: UBERON:0010000 ! multicellular anatomical structure property_value: editor_note "TODO - split body and mc organism? body continues after death stage" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000007 "organismal" xsd:string [Term] id: UBERON:0000471 name: compound organ component namespace: uberon def: "Multi-tissue structure that is part of a compound organ." [CARO:0000019, http://orcid.org/0000-0001-9114-8737] subset: human_subset subset: mouse_subset subset: upper_level synonym: "compound organ components" RELATED OMO:0003004 [ZFA:0001489] xref: AAO:0010017 xref: AEO:0000019 xref: BILA:0000019 xref: CARO:0000019 xref: EHDAA2:0003019 xref: HAO:0000019 xref: TAO:0001489 xref: TGMA:0001835 xref: XAO:0003039 xref: ZFA:0001489 is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of UBERON:0003103 ! compound organ property_value: IAO:0000232 "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" xsd:string [Term] id: UBERON:0000474 name: female reproductive system namespace: uberon def: "The organs and associated structures associated with bearing offspring in a female animal." [http://orcid.org/0000-0002-6601-2165, MP:0001119, Wikipedia:Female_genitalia] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "female genital system" RELATED [] synonym: "female genital tract" RELATED [] synonym: "female genitalia" RELATED [] synonym: "female genitals" RELATED OMO:0003004 [XAO:0000156] synonym: "female organism genitalia" EXACT [OBOL:automatic] synonym: "female organism reproductive system" EXACT [OBOL:automatic] synonym: "female reproductive tract" RELATED [MA:0000381] synonym: "genitalia of female organism" EXACT [OBOL:automatic] synonym: "gynaecological tissue" RELATED [BTO:0000083] synonym: "reproductive system of female organism" EXACT [OBOL:automatic] synonym: "systema genitale femininum" RELATED [BTO:0000083] xref: BTO:0000083 xref: CALOHA:TS-1303 xref: EFO:0000969 xref: EHDAA2:0000506 xref: EHDAA:8116 xref: EMAPA:17959 xref: EV:0100110 xref: FBbt:00004864 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45663 xref: GAID:364 xref: HAO:0000324 xref: MA:0000381 xref: MESH:D005836 xref: MIAA:0000028 xref: NCIT:C12402 xref: SCTID:361386004 xref: TGMA:0000635 xref: UMLS:C0700038 {source="ncithesaurus:Female_Reproductive_System"} xref: VHOG:0000726 xref: Wikipedia:Female_genitalia xref: WikipediaCategory:Female_reproductive_system xref: XAO:0000156 is_a: UBERON:0000990 ! reproductive system intersection_of: UBERON:0000990 ! reproductive system intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0003100 ! female organism property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000726", ontology="VHOG", source="ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000475 name: organism subdivision namespace: uberon def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomic region" EXACT [MA:0002433] synonym: "body part" RELATED [] synonym: "body region" RELATED [FMA:7153] synonym: "cardinal body part" RELATED [FMA:7153] xref: AAO:0010053 xref: AEO:0000032 xref: BILA:0000032 xref: BIRNLEX:7 xref: CALOHA:TS-2084 xref: CARO:0000032 xref: EFO:0000808 xref: EHDAA2:0003032 xref: EMAPA:36031 xref: FBbt:00007009 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7153 xref: galen:BodyPart xref: HAO:0000032 xref: MA:0002433 xref: MAT:0000293 xref: MESH:D001829 xref: MIAA:0000293 xref: NCIT:C32221 xref: TAO:0001308 xref: TGMA:0001840 xref: UMLS:C0229962 {source="ncithesaurus:Body_Part"} xref: VHOG:0001758 xref: Wikipedia:Body_part xref: XAO:0003013 xref: ZFA:0001308 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: has_part UBERON:0000075 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! subdivision of skeletal system relationship: has_part UBERON:0034929 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! external soft tissue zone relationship: overlaps UBERON:0001009 {gci_filler="NCBITaxon:33213", gci_relation="in_taxon"} ! circulatory system relationship: overlaps UBERON:0001015 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! musculature relationship: overlaps UBERON:0001016 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! nervous system relationship: overlaps UBERON:0001434 {gci_filler="NCBITaxon:33213", gci_relation="in_taxon"} ! skeletal system relationship: overlaps UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! integumental system relationship: part_of UBERON:0000468 ! multicellular organism property_value: editor_note "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000476 name: acellular anatomical structure namespace: uberon def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "acellular anatomical structures" RELATED OMO:0003004 [ZFA:0000382] xref: AAO:0010268 xref: AEO:0000040 xref: BILA:0000040 xref: CARO:0000040 xref: EHDAA2:0003040 xref: FBbt:00007013 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:63863 xref: HAO:0000040 xref: TAO:0000382 xref: TGMA:0001841 xref: XAO:0003162 xref: ZFA:0000382 is_a: UBERON:0000061 ! anatomical structure disjoint_from: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000477 name: anatomical cluster namespace: uberon def: "Anatomical group whose component anatomical structures lie in close proximity to each other." [FBbt:00007277] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level xref: FBbt:00007277 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: VHOG:0001737 is_a: UBERON:0034923 ! disconnected anatomical group property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000478 name: extraembryonic structure namespace: uberon def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [CARO:DOS, http://orcid.org/0000-0001-9114-8737, https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279] comment: see also conceptus extraembryonic component in EHDAA2. subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "extra-embryonic structure" EXACT [] synonym: "extraembryonic structures" RELATED OMO:0003004 [ZFA:0000020] synonym: "extraembryonic tissue" RELATED [] xref: AAO:0010020 xref: AEO:0000042 xref: BILA:0000042 xref: CALOHA:TS-2119 xref: CARO:0000042 xref: EHDAA2:0003042 xref: EHDAA:46 xref: FBbt:00005835 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:85537 xref: HAO:0000042 xref: NCIT:C34055 xref: SCTID:314908006 xref: TAO:0000020 xref: TGMA:0001843 xref: UMLS:C1282438 {source="ncithesaurus:Extraembryonic_Structure"} xref: VHOG:0000292 xref: XAO:0004005 xref: ZFA:0000020 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: part_of UBERON:0016887 ! entire extraembryonic component relationship: existence_starts_and_ends_during UBERON:0000068 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! embryo stage relationship: part_of UBERON:0016887 ! entire extraembryonic component [Term] id: UBERON:0000479 name: tissue namespace: uberon def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [CARO:0000043] subset: common_anatomy subset: human_subset subset: mouse_subset subset: pheno_slim subset: upper_level synonym: "portion of tissue" EXACT [CARO:0000043] synonym: "simple tissue" NARROW [AEO:0000043] synonym: "tissue portion" EXACT [] xref: AAO:0000607 xref: AAO:0010054 xref: AEO:0000043 xref: BILA:0000043 xref: BIRNLEX:19 xref: CALOHA:TS-2090 xref: CARO:0000043 xref: EHDAA2:0003043 xref: EMAPA:35868 xref: FBbt:00007003 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9637 xref: galen:Tissue xref: HAO:0000043 xref: MA:0003002 xref: MESH:D014024 xref: NCIT:C12801 xref: TAO:0001477 xref: TGMA:0001844 xref: UMLS:C0040300 {source="ncithesaurus:Tissue"} xref: VHOG:0001757 xref: WBbt:0005729 xref: XAO:0003040 xref: ZFA:0001477 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: has_part GO:0031012 ! extracellular matrix relationship: part_of UBERON:0000468 ! multicellular organism property_value: editor_note "changed label and definition to reflect CARO2" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000481 name: multi-tissue structure namespace: uberon def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:0000055, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level synonym: "multi-tissue structures" RELATED OMO:0003004 [ZFA:0001488] xref: AAO:0010048 xref: AEO:0000055 xref: BILA:0000055 xref: CARO:0000055 xref: EHDAA2:0003055 xref: FBbt:00007010 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000055 xref: TAO:0001488 xref: TGMA:0001847 xref: VHOG:0001762 xref: XAO:0003037 xref: ZFA:0001488 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: has_part UBERON:0000479 ! tissue relationship: part_of NCBITaxon:6072 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! Eumetazoa property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000482 name: basal lamina of epithelium namespace: uberon def: "Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue." [http://orcid.org/0000-0001-9114-8737] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "basal lamina" RELATED [CARO:0000065] synonym: "basal lamina of connective tissue" EXACT [FMA:62918] synonym: "basal laminae" RELATED OMO:0003004 [VHOG:0001592] synonym: "lamina basalis" RELATED OMO:0003011 [Wikipedia:Basal_lamina] xref: AAO:0010269 xref: AEO:0000065 xref: BILA:0000065 xref: CARO:0000065 xref: EHDAA2:0003065 xref: FMA:62918 xref: HAO:0000065 xref: MESH:D001485 xref: NCIT:C32186 xref: NIF_Subcellular:sao1397492660 xref: TAO:0001485 xref: TGMA:0001850 xref: UMLS:C0085872 {source="ncithesaurus:Basal_Lamina"} xref: VHOG:0001592 xref: WBbt:0005756 xref: Wikipedia:Basal_lamina xref: XAO:0003163 xref: ZFA:0001485 is_a: UBERON:0005764 {source="FMA"} ! acellular membrane relationship: composed_primarily_of GO:0005604 ! basement membrane relationship: part_of UBERON:0005769 {source="FMA"} ! basement membrane of epithelium property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/6/65/Basal_lamina.jpg xsd:anyURI property_value: IAO:0000232 "this class represents a continuous sheet of basal lamina which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal lamina' represents a portion of substance on the scale of a single cell." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "A basal lamina is certainly present in Bilateria and was evaluated as an autapomorphy of this taxon.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001592", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.57", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000483 name: epithelium namespace: uberon def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Epithelium] comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithelial tissue" EXACT [] synonym: "portion of epithelium" EXACT [FMA:9639] xref: AAO:0000144 xref: AAO:0010055 xref: AEO:0000066 xref: BILA:0000066 xref: BTO:0000416 xref: CALOHA:TS-0288 xref: CARO:0000066 xref: EHDAA2:0003066 xref: EMAPA:32738 xref: FBbt:00007005 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9639 xref: GAID:402 xref: HAO:0000066 xref: MA:0003060 xref: MESH:D004848 xref: NCIT:C12710 xref: SCTID:31610004 xref: TAO:0001486 xref: UMLS:C0014609 {source="ncithesaurus:Epithelium"} xref: VHOG:0000387 xref: Wikipedia:Epithelium xref: XAO:0003045 xref: ZFA:0001486 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of CL:0000066 ! epithelial cell union_of: UBERON:0000486 ! multilaminar epithelium union_of: UBERON:0000490 ! unilaminar epithelium relationship: composed_primarily_of CL:0000066 ! epithelial cell relationship: has_part GO:0005911 ! cell-cell junction relationship: has_part UBERON:0005769 ! basement membrane of epithelium relationship: in_taxon NCBITaxon:33208 {source="http://palaeos.com/metazoa/porifera/homoscleromorpha.html"} ! Metazoa property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg xsd:anyURI property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "epithelial" xsd:string [Term] id: UBERON:0000484 name: simple cuboidal epithelium namespace: uberon def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_cuboidal_epithelium] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "epithelium simplex cuboideum" EXACT [] synonym: "simple cuboidal epithelia" RELATED OMO:0003004 [ZFA:0001497] xref: AAO:0010064 xref: AEO:0000067 xref: BILA:0000067 xref: CARO:0000067 xref: EHDAA2:0003067 xref: FMA:45566 xref: HAO:0000067 xref: NCIT:C33553 xref: TAO:0001497 xref: UMLS:C0836134 {source="ncithesaurus:Simple_Cuboidal_Epithelium"} xref: Wikipedia:Simple_cuboidal_epithelium xref: XAO:0004009 xref: ZFA:0001497 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium property_value: editor_note "needs to be synchronized with CL - there is no distinct cuboidal cell in CL" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png xsd:anyURI [Term] id: UBERON:0000485 name: simple columnar epithelium namespace: uberon def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_columnar_epithelium] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "columnar epithelium" BROAD [EHDAA2:0003068] synonym: "columnar epithlium" BROAD [AEO:0000068] synonym: "epithelium simplex columnare" EXACT [] synonym: "simple columnar epithelia" RELATED OMO:0003004 [ZFA:0001496] synonym: "simple columnar epithelium" EXACT [] xref: AAO:0010063 xref: AEO:0000068 xref: BILA:0000068 xref: CARO:0000068 xref: EHDAA2_RETIRED:0003068 xref: FBbt:00007027 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45567 xref: HAO:0000068 xref: NCIT:C33552 xref: SCTID:32210007 xref: TAO:0001496 xref: UMLS:C0836135 {source="ncithesaurus:Simple_Columnar_Epithelium"} xref: Wikipedia:Simple_columnar_epithelium xref: XAO:0004008 xref: ZFA:0001496 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png xsd:anyURI [Term] id: UBERON:0000486 name: multilaminar epithelium namespace: uberon def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Stratified_epithelium] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "laminated epithelium" RELATED [BTO:0002074] synonym: "stratified epithelium" EXACT [] xref: AAO:0010059 xref: AEO:0000069 xref: BILA:0000069 xref: BTO:0002074 xref: CARO:0000069 xref: EHDAA2:0003069 xref: FMA:45562 xref: HAO:0000069 xref: NCIT:C33622 xref: SCTID:309044005 xref: TAO:0001494 xref: UMLS:C0682575 {source="ncithesaurus:Stratified_Epithelium"} xref: Wikipedia:Stratified_epithelium xref: XAO:0004006 xref: ZFA:0001494 is_a: UBERON:0000483 ! epithelium property_value: UBPROP:0000001 "Epithelium that consists of more than one layer of epithelial cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000069", ontology="CARO", source="FMA:45562", source="http://orcid.org/0000-0001-9114-8737"} [Term] id: UBERON:0000487 name: simple squamous epithelium namespace: uberon def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." [FMA:45565, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_squamous_epithelium] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "epithelium simplex squamosum" EXACT [] synonym: "simple squamous epithelia" RELATED OMO:0003004 [ZFA:0001498] xref: AAO:0010066 xref: AEO:0000070 xref: BILA:0000070 xref: BTO:0002073 xref: CARO:0000070 xref: EHDAA2:0003070 xref: FMA:45565 xref: HAO:0000070 xref: NCIT:C13178 xref: TAO:0001498 xref: UMLS:C0836133 {source="ncithesaurus:Simple_Squamous_Epithelium"} xref: Wikipedia:Simple_squamous_epithelium xref: XAO:0004010 xref: ZFA:0001498 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: composed_primarily_of CL:0000076 ! squamous epithelial cell property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg xsd:anyURI property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"} [Term] id: UBERON:0000488 name: atypical epithelium namespace: uberon def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [http://orcid.org/0000-0001-9114-8737] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "atypical epithelia" RELATED OMO:0003004 [ZFA:0001493] synonym: "heterogenous epithelium" EXACT [] xref: AAO:0010057 xref: AEO:0000071 xref: BILA:0000071 xref: CARO:0000071 xref: EHDAA2:0003071 xref: FMA:61741 xref: HAO:0000071 xref: TAO:0001493 xref: XAO:0004004 xref: ZFA:0001493 is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000489 name: cavitated compound organ namespace: uberon def: "Compound organ that contains one or more macroscopic anatomical spaces." [http://orcid.org/0000-0001-9114-8737] subset: human_subset subset: mouse_subset subset: organ_slim subset: upper_level synonym: "cavitated compound organs" RELATED OMO:0003004 [ZFA:0001490] synonym: "cavitated organ" EXACT [FMA:55671] xref: AAO:0010016 xref: AEO:0000072 xref: BILA:0000072 xref: CARO:0000072 xref: EHDAA2:0003072 xref: FMA:55671 xref: HAO:0000072 xref: TAO:0001490 xref: TGMA:0001857 xref: VHOG:0001730 xref: XAO:0003165 xref: ZFA:0001490 is_a: UBERON:0003103 ! compound organ intersection_of: UBERON:0003103 ! compound organ intersection_of: has_part UBERON:0002553 ! anatomical cavity relationship: has_part UBERON:0002553 ! anatomical cavity property_value: IAO:0000232 "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" xsd:string [Term] id: UBERON:0000490 name: unilaminar epithelium namespace: uberon def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." [FMA:45561, http://orcid.org/0000-0001-9114-8737] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "simple epithelium" EXACT [FMA:45561] synonym: "unilaminar epithelia" RELATED OMO:0003004 [ZFA:0001495] xref: AAO:0010062 xref: AEO:0000073 xref: BILA:0000073 xref: BTO:0002073 xref: CARO:0000073 xref: EHDAA2:0003073 xref: FMA:45561 xref: HAO:0000073 xref: NCIT:C33554 xref: SCTID:309043004 xref: TAO:0001495 xref: UMLS:C0682574 {source="ncithesaurus:Simple_Epithelium"} xref: XAO:0004007 xref: ZFA:0001495 is_a: UBERON:0000483 ! epithelium property_value: editor_note "consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable" xsd:string property_value: UBPROP:0000001 "Epithelium that consists of a single layer of epithelial cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000073", ontology="CARO", source="FMA:45561", source="http://orcid.org/0000-0001-9114-8737"} [Term] id: UBERON:0000912 name: mucus namespace: uberon def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus] subset: human_subset subset: mouse_subset xref: CALOHA:TS-2144 xref: ENVO:02000040 xref: FMA:66938 xref: GAID:1164 xref: galen:Mucus xref: MESH:D009093 xref: NCIT:C13259 xref: UMLS:C0026727 {source="ncithesaurus:Mucus"} xref: Wikipedia:Mucus is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid relationship: has_part CHEBI:37395 ! mucopolysaccharide relationship: has_quality PATO:0000998 ! viscous relationship: produced_by UBERON:0000344 ! mucosa property_value: UBPROP:0000007 "mucoid" xsd:string property_value: UBPROP:0000007 "mucous" xsd:string [Term] id: UBERON:0000915 name: thoracic segment of trunk namespace: uberon def: "Subdivision of trunk that lies between the head and the abdomen." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "anterior subdivision of trunk" RELATED [] synonym: "thorax" EXACT [MA:0000022] synonym: "upper body" RELATED [] synonym: "upper trunk" RELATED [FMA:259209] xref: EMAPA:35862 xref: FMA:259209 xref: MA:0000022 xref: SCTID:302551006 xref: Wikipedia:Thorax is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: has_skeleton UBERON:0014477 ! thoracic skeleton relationship: has_skeleton UBERON:0014477 ! thoracic skeleton property_value: IAO:0000232 "note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest" xsd:string property_value: RO:0002171 UBERON:0000026 property_value: RO:0002171 UBERON:0000033 property_value: RO:0002171 UBERON:0002417 [Term] id: UBERON:0000916 name: abdomen namespace: uberon def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "abdominopelvic region" EXACT [FMA:9577] synonym: "abdominopelvis" EXACT [FMA:9577] synonym: "adult abdomen" RELATED [] synonym: "belly" RELATED [] synonym: "celiac region" RELATED [] xref: BTO:0000020 xref: CALOHA:TS-0001 xref: EFO:0000968 xref: EMAPA:35102 xref: EV:0100011 xref: FMA:9577 xref: GAID:16 xref: galen:Abdomen xref: MA:0000029 xref: MAT:0000298 xref: MESH:D000005 xref: MIAA:0000298 xref: SCTID:302553009 xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002417 {source="MA"} ! abdominal segment of trunk property_value: editor_note "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" xsd:string property_value: UBPROP:0000007 "abdominal" xsd:string property_value: UBPROP:0000007 "celiac" xsd:string [Term] id: UBERON:0000922 name: embryo namespace: uberon def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [BTO:0000379, FB:FBrf0039741, FB:FBrf0041814, GO:0009790, Wikipedia:Embryo] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "developing organism" RELATED [BILA:0000056] synonym: "developmental tissue" RELATED [] synonym: "embryonic organism" EXACT [BILA:0000056] xref: AAO:0011035 xref: AEO:0000169 xref: BILA:0000056 xref: BSA:0000039 xref: BTO:0000379 xref: CALOHA:TS-0229 xref: EFO:0001367 xref: EHDAA2:0000002 xref: EHDAA2_RETIRED:0003236 xref: EHDAA:38 xref: EMAPA:16039 xref: FBbt:00000052 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69068 xref: GAID:963 xref: http://neurolex.org/wiki/Category\:Embryonic_organism xref: IDOMAL:0000646 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: MAT:0000226 xref: MESH:D004622 xref: MIAA:0000019 xref: NCIT:C28147 xref: OGEM:000001 xref: SCTID:57991002 xref: UMLS:C0013935 {source="ncithesaurus:Embryo"} xref: VHOG:0001766 xref: Wikipedia:Embryo xref: XAO:0000113 xref: ZFA:0000103 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: existence_ends_with UBERON:0000068 ! embryo stage intersection_of: existence_starts_with UBERON:0000068 ! embryo stage relationship: existence_ends_with UBERON:0000068 ! embryo stage relationship: existence_starts_with UBERON:0000068 ! embryo stage property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/503 xsd:anyURI property_value: UBPROP:0000007 "embryonic" xsd:string property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0000923 name: germ layer namespace: uberon def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [https://github.com/obophenotype/uberon/issues/203, Wikipedia:Germ_layer] comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "embryonic germ layer" RELATED [] synonym: "embryonic germ layers" RELATED [] synonym: "embryonic tissue" BROAD [FMA:69069] synonym: "germinal layer" EXACT [ncithesaurus:Germinal_Layer] synonym: "primary germ layer" NARROW [GO:0001704, ZFA:0001122] xref: AAO:0000480 xref: BILA:0000035 xref: BTO:0000556 xref: EMAPA:36033 xref: FBbt:00000110 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69069 xref: GAID:1303 xref: MESH:D005855 xref: NCIT:C12950 xref: NCIT:C54105 xref: TAO:0001122 xref: UMLS:C0920502 {source="ncithesaurus:Embryonic_Tissue"} xref: UMLS:C1708239 {source="ncithesaurus:Germinal_Layer"} xref: VHOG:0001223 xref: Wikipedia:Germ_layer xref: XAO:0003011 xref: ZFA:0001122 is_a: UBERON:0010316 ! germ layer / neural crest relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001223", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000924 name: ectoderm namespace: uberon def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [Wikipedia:Ectoderm] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic ectoderm" EXACT [VHOG:0000153] xref: AAO:0000137 xref: BILA:0000036 xref: BTO:0000315 xref: CALOHA:TS-0216 xref: EFO:0000414 xref: EHDAA2:0000428 xref: EMAPA:16069 xref: EV:0100003 xref: FBbt:00000111 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69070 xref: GAID:1304 xref: MAT:0000155 xref: MAT:0000173 xref: MESH:D004475 xref: MIAA:0000173 xref: NCIT:C12703 xref: SCTID:362851007 xref: TAO:0000016 xref: UMLS:C0013574 {source="ncithesaurus:Ectoderm"} xref: VHOG:0000153 xref: Wikipedia:Ectoderm xref: XAO:0000001 xref: ZFA:0000016 is_a: UBERON:0000923 ! germ layer relationship: develops_from UBERON:0000307 ! blastula relationship: develops_from UBERON:0006601 ! presumptive ectoderm relationship: has_part CL:0000221 ! ectodermal cell relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png xsd:anyURI property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "ectodermal" xsd:string [Term] id: UBERON:0000925 name: endoderm namespace: uberon def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [Wikipedia:Endoderm] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "entoderm" RELATED DEPRECATED [DOI:10.5962/bhl.title.1013] xref: AAO:0000139 xref: BILA:0000038 xref: BTO:0000800 xref: CALOHA:TS-0273 xref: EFO:0002545 xref: EHDAA2:0000436 xref: EMAPA:16062 xref: EV:0100005 xref: FBbt:00000125 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69071 xref: GAID:1305 xref: MAT:0000175 xref: MESH:D004707 xref: MIAA:0000175 xref: NCIT:C12706 xref: SCTID:362855003 xref: TAO:0000017 xref: UMLS:C0014144 {source="ncithesaurus:Endoderm"} xref: VHOG:0000154 xref: Wikipedia:Endoderm xref: XAO:0000090 xref: ZFA:0000017 is_a: UBERON:0000923 ! germ layer relationship: develops_from UBERON:0000307 ! blastula relationship: develops_from UBERON:0006595 ! presumptive endoderm relationship: has_part CL:0000223 ! endodermal cell relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png xsd:anyURI property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "endodermal" xsd:string [Term] id: UBERON:0000926 name: mesoderm namespace: uberon alt_id: UBERON:0003263 def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [Wikipedia:Mesoderm] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic mesoderm" RELATED [VHOG:0000152] synonym: "entire mesoderm" RELATED [https://orcid.org/0000-0002-6601-2165, SCTID:362854004] synonym: "mesodermal mantle" RELATED [] xref: AAO:0000304 xref: BILA:0000037 xref: BTO:0000839 xref: CALOHA:TS-0623 xref: EFO:0001981 xref: EHDAA2:0001128 xref: EHDAA:124 xref: EHDAA:160 xref: EHDAA:183 xref: EMAPA:16083 xref: EV:0100006 xref: FBbt:00000126 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69072 xref: GAID:522 xref: MAT:0000174 xref: MESH:D008648 xref: MIAA:0000174 xref: NCIT:C12750 xref: SCTID:362854004 xref: TAO:0000041 xref: UMLS:C0025485 {source="ncithesaurus:Mesoderm"} xref: VHOG:0000152 xref: Wikipedia:Mesoderm xref: XAO:0000050 xref: ZFA:0000041 is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer relationship: develops_from UBERON:0000307 ! blastula relationship: develops_from UBERON:0006603 ! presumptive mesoderm relationship: has_part CL:0000222 ! mesodermal cell relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png xsd:anyURI property_value: RO:0002161 NCBITaxon:6040 property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "mesodermal" xsd:string property_value: UBPROP:0000008 "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" xsd:string {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} [Term] id: UBERON:0000930 name: stomodeum namespace: uberon def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/326, Wikipedia:Stomodeum] subset: grouping_class subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mouth pit" RELATED [EMAPA:16263] synonym: "mouth primordium" EXACT [XAO:0000269] synonym: "oral ectoderm" RELATED [ZFA:0001290, ZFIN:ZDB-PUB-100726-23] synonym: "oral pit" RELATED [EMAPA:16263] synonym: "primitive oral cavity" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "stomatodeum" EXACT [Wikipedia:Stomodeum] synonym: "stomodaeum" EXACT [] synonym: "stomodeal-hypophyseal primordium" BROAD [XAO:0000269] xref: BTO:0004224 xref: EHDAA2:0001929 xref: EMAPA:16263 xref: FBbt:00000439 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:295846 xref: NCIT:C34306 xref: TAO:0001290 xref: TGMA:0000135 xref: UMLS:C1514977 {source="ncithesaurus:Stomodeum"} xref: Wikipedia:Stomodeum xref: XAO:0000269 xref: ZFA:0001290 is_a: UBERON:0013522 ! subdivision of tube relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0035804 ! future mouth property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png xsd:anyURI property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"} property_value: UBPROP:0000007 "stomodeal" xsd:string property_value: UBPROP:0000008 "This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity." xsd:string [Term] id: UBERON:0000931 name: proctodeum namespace: uberon def: "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." [https://github.com/obophenotype/uberon/issues/685, https://sourceforge.net/p/fbbtdv/tickets/52, ZFA:0000066] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "amnioproctodeal invagination" NARROW [FBbt:00000123] synonym: "anal pit" RELATED [VHOG:0000139] synonym: "anus porus" RELATED [XAO:0001019] synonym: "embryonic proctodaeum" EXACT [] synonym: "proctodaeum" EXACT [] xref: AAO:0011087 xref: EHDAA2:0000121 xref: EMAPA:25038 xref: FBbt:00000123 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: NCIT:C34278 xref: TAO:0000066 xref: UMLS:C0231054 {source="ncithesaurus:Proctodeum"} xref: VHOG:0000139 xref: Wikipedia:Proctodeum xref: XAO:0001019 xref: ZFA:0000066 is_a: UBERON:0016566 {source="EHDAA2"} ! pit relationship: develops_from UBERON:0000924 ! ectoderm relationship: has_potential_to_develop_into UBERON:0001353 ! anal region relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: located_in UBERON:0012469 {source="EHDAA2"} ! external anal region relationship: part_of UBERON:0007026 ! presumptive gut property_value: editor_note "removed WBbt:0006795 'proctodeum' - junction between the alimentary and genital tracts in the male." xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/ANiknejad property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/dosumis property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mmc46 property_value: seeAlso https://github.com/obophenotype/uberon/issues/685 xsd:anyURI property_value: UBPROP:0000001 "An inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000066", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011087", ontology="AAO", source="ZFA:0000066"} property_value: UBPROP:0000007 "proctodeal" xsd:string [Term] id: UBERON:0000945 name: stomach namespace: uberon def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Stomach] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior intestine" RELATED [] synonym: "gaster" RELATED [BTO:0001307] synonym: "mesenteron" RELATED [] synonym: "stomach chamber" NARROW [] synonym: "ventriculus" RELATED OMO:0003011 [Wikipedia:Stomach] xref: AAO:0000579 xref: ANISEED:1235297 xref: BTO:0001307 xref: CALOHA:TS-0980 xref: EFO:0000837 xref: EHDAA2:0001915 xref: EHDAA:2993 xref: EMAPA:17021 xref: EV:0100070 xref: FMA:7148 xref: GAID:293 xref: galen:Stomach xref: MA:0000353 xref: MAT:0000051 xref: MESH:D013270 xref: MIAA:0000051 xref: NCIT:C12391 xref: SCTID:181246003 xref: TAO:0002121 xref: UMLS:C0038351 {source="ncithesaurus:Stomach"} xref: VHOG:0000408 xref: Wikipedia:Stomach xref: XAO:0000128 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract is_a: UBERON:0010039 {source="cjm"} ! food storage organ relationship: capable_of GO:0001696 {evidence="ISBN:0486692132"} ! gastric acid secretion relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system relationship: in_taxon NCBITaxon:7776 {notes="absent in lampreys and hagfishes", source="ISBN:0073040584"} ! Gnathostomata relationship: part_of UBERON:0001041 ! foregut property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:7864 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7878 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7955 {source="ZFA"} property_value: RO:0002161 NCBITaxon:9259 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000579", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000408", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00076.x Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM, Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evolution and development (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa" xsd:string {source="WP:Stomach#In_other_animals"} [Term] id: UBERON:0000947 name: aorta namespace: uberon def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta] subset: efo_slim subset: grouping_class subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "arteria maxima" RELATED OMO:0003011 [Wikipedia:Aorta] synonym: "dorsal aorta" NARROW SENSU [Wikipedia:Aorta#In_other_animals, ZFA:0000014] synonym: "trunk of aortic tree" EXACT [] synonym: "trunk of systemic arterial tree" EXACT [] xref: AAO:0010213 xref: BTO:0000135 xref: CALOHA:TS-0046 xref: EFO:0000265 xref: EMAPA:18601 xref: EV:0100027 xref: FMA:3734 xref: GAID:469 xref: galen:Aorta xref: MA:0000062 xref: MAT:0000035 xref: MESH:D001011 xref: MIAA:0000035 xref: NCIT:C12669 xref: SCTID:181298001 xref: UMLS:C0003483 {source="ncithesaurus:Aorta"} xref: VHOG:0001523 xref: Wikipedia:Aorta xref: XAO:0003010 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel is_a: UBERON:0003519 ! thoracic cavity blood vessel is_a: UBERON:0013768 ! great vessel of heart relationship: connected_to UBERON:0002084 ! heart left ventricle relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0010191 {source="EHDAA2"} ! aortic system property_value: editor_note "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." xsd:string {source="WP"} property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010213", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001523", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "aortic" xsd:string property_value: UBPROP:0000008 "All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches" xsd:string [Term] id: UBERON:0000948 name: heart namespace: uberon def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart] comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "branchial heart" NARROW SENSU [] synonym: "cardium" RELATED [EMAPA:16105] synonym: "chambered heart" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "vertebrate heart" EXACT [] xref: AAO:0010210 xref: BILA:0000020 xref: BTO:0000562 xref: CALOHA:TS-0445 xref: EFO:0000815 xref: EHDAA2:0000738 xref: EHDAA:420 xref: EMAPA:16105 xref: EV:0100018 xref: FMA:7088 xref: GAID:174 xref: galen:Heart xref: MA:0000072 xref: MAT:0000036 xref: MESH:D006321 xref: MIAA:0000036 xref: NCIT:C12727 xref: SCTID:302509004 xref: TAO:0000114 xref: UMLS:C0018787 {source="ncithesaurus:Heart"} xref: VHOG:0000276 xref: Wikipedia:Heart xref: XAO:0000064 xref: ZFA:0000114 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0007100 ! primary circulatory organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0007100 ! primary circulatory organ intersection_of: has_part UBERON:0004151 ! cardiac chamber relationship: contributes_to_morphology_of UBERON:0004535 ! cardiovascular system relationship: develops_from UBERON:0004141 ! heart tube relationship: has_part UBERON:0004151 ! cardiac chamber relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0015410 {source="MA"} ! heart plus pericardium property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002161 NCBITaxon:6239 property_value: RO:0002161 NCBITaxon:7227 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000114", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO"} property_value: UBPROP:0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000276", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "cardiac" xsd:string [Term] id: UBERON:0000949 name: endocrine system namespace: uberon def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [NLM:endocrine+system, Wikipedia:Endocrine_system] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocrine glandular system" EXACT [EHDAA2:0002224] synonym: "endocrine system" EXACT [] synonym: "systema endocrinum" EXACT [] xref: AAO:0010279 xref: CALOHA:TS-1301 xref: EFO:0002969 xref: EHDAA2:0002224 xref: EMAPA:35306 xref: EV:0100128 xref: FBbt:00005068 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9668 xref: GAID:439 xref: MA:0000012 xref: MESH:D004703 xref: NCIT:C12705 xref: SCTID:278876000 xref: TAO:0001158 xref: UMLS:C0014136 {source="ncithesaurus:Endocrine_System"} xref: VHOG:0000098 xref: Wikipedia:Endocrine_system xref: XAO:0000158 xref: ZFA:0001158 is_a: UBERON:0015204 ! glandular system disjoint_from: UBERON:0000990 ! reproductive system disjoint_from: UBERON:0001004 ! respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: composed_primarily_of UBERON:0002368 ! endocrine gland relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: UBPROP:0000001 "Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010279", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000098", ontology="VHOG", source="DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "endocrine" xsd:string [Term] id: UBERON:0000955 name: brain namespace: uberon def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Brain] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "encephalon" RELATED [BTO:0000142] synonym: "suprasegmental levels of nervous system" RELATED [NeuroNames:21] synonym: "suprasegmental structures" RELATED [NeuroNames:21] synonym: "synganglion" RELATED [] synonym: "the brain" RELATED [NeuroNames:21] xref: AAO:0010478 xref: ABA:Brain xref: BAMS:Br xref: BAMS:Brain xref: BILA:0000135 xref: BIRNLEX:796 xref: BTO:0000142 xref: CALOHA:TS-0095 xref: DHBA:10155 xref: EFO:0000302 xref: EHDAA2:0000183 xref: EHDAA:2641 xref: EHDAA:6485 xref: EMAPA:16894 xref: EV:0100164 xref: FBbt:00005095 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:50801 xref: GAID:571 xref: galen:Brain xref: HBA:4005 xref: MA:0000168 xref: MAT:0000098 xref: MBA:8 xref: MBA:997 xref: MESH:D001921 xref: MIAA:0000098 xref: NCIT:C12439 xref: neuronames:21 {source="BIRNLEX:796"} xref: PBA:3999 xref: SCTID:258335003 xref: TAO:0000008 xref: UMLS:C0006104 {source="ncithesaurus:Brain", source="BIRNLEX:796"} xref: UMLS:C1269537 {source="BIRNLEX:796"} xref: VHOG:0000157 xref: Wikipedia:Brain xref: XAO:0000010 xref: ZFA:0000008 is_a: UBERON:0000062 {source="GO"} ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: capable_of GO:0050890 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! cognition relationship: composed_primarily_of CL:0002319 ! neural cell relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system relationship: develops_from UBERON:0001049 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! neural tube relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0006238 ! future brain relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: immediate_transformation_of UBERON:0006238 {source="Bgee:AN"} ! future brain relationship: in_anterior_side_of UBERON:0000468 ! multicellular organism relationship: part_of UBERON:0001017 {source="FMA"} ! central nervous system property_value: editor_note "requires review for applicability to invertebrate structures, e.g. synganglion" xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000008", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010478", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000157", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000957 name: lamina namespace: uberon def: "Any thin layer or plate." [Wikipedia:Lamina_of_the_vertebral_arch] subset: human_subset subset: mouse_subset subset: non_informative subset: uberon_slim subset: upper_level synonym: "laminar tissue" EXACT [] xref: Wikipedia:Lamina_of_the_vertebral_arch is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: has_quality PATO:0002124 ! laminar relationship: has_quality PATO:0002124 ! laminar property_value: editor_note "TODO - merge with cell layer?" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png xsd:anyURI property_value: UBPROP:0000007 "laminar" xsd:string [Term] id: UBERON:0000962 name: nerve of cervical vertebra namespace: uberon def: "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." [Wikipedia:Cervical_nerves] comment: Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "cervical nerve" EXACT [FMA:5859] synonym: "cervical nerve tree" EXACT [] synonym: "cervical spinal nerve" EXACT [] synonym: "nervus cervicalis" EXACT OMO:0003011 [FMA:5859, FMA:TA] xref: BAMS:cern xref: FMA:5859 xref: NCIT:C32299 xref: neuronames:2351 xref: NLXANAT:20090207 xref: SCTID:360497008 xref: UMLS:C0228815 {source="ncithesaurus:Cervical_Nerve"} xref: Wikipedia:Cervical_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000963 name: head sensillum namespace: uberon xref: FBbt:00004114 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MAT:0000204 xref: MIAA:0000204 is_a: UBERON:0002536 ! arthropod sensillum intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head property_value: editor_note "this term should be ceded to the arthropod anatomy ontology" xsd:string [Term] id: UBERON:0000964 name: cornea namespace: uberon def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cornea of camera-type eye" EXACT [GO:0061303] synonym: "corneas" RELATED OMO:0003004 [ZFA:0000640] synonym: "tunica cornea" RELATED [] xref: AAO:0010344 xref: BTO:0000286 xref: CALOHA:TS-0171 xref: EFO:0000377 xref: EHDAA2:0000316 xref: EHDAA:10199 xref: EMAPA:17161 xref: EV:0100341 xref: FMA:58238 xref: GAID:892 xref: MA:0000266 xref: MESH:D003315 xref: NCIT:C12342 xref: SCTID:181162001 xref: TAO:0000640 xref: UMLS:C0010031 {source="ncithesaurus:Cornea"} xref: VHOG:0000164 xref: Wikipedia:Cornea xref: XAO:0000180 xref: ZFA:0000640 is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: continuous_with UBERON:0001773 ! sclera relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball relationship: developmentally_induced_by UBERON:0005426 ! lens vesicle relationship: develops_from UBERON:0004348 {evidence="definitional"} ! optic eminence relationship: develops_from UBERON:0005427 ! corneal primordium relationship: has_part UBERON:0001772 ! corneal epithelium relationship: has_part UBERON:0004370 ! anterior limiting lamina of cornea relationship: has_quality PATO:0000964 ! transparent relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "corneal" xsd:string property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string [Term] id: UBERON:0000965 name: lens of camera-type eye namespace: uberon def: "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)] comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "camera-type eye lens" EXACT [GO:0002088] synonym: "crystalline lens" RELATED [BTO:0000723, PMID:36055924] synonym: "eye lens" EXACT SENSU [] synonym: "lens" EXACT SENSU [] synonym: "lens crystallina" EXACT [Wikipedia:Lens_(anatomy)] synonym: "lenses" RELATED OMO:0003004 [ZFA:0000035] synonym: "ocular lens" RELATED [BTO:0000723] xref: AAO:0010348 xref: BTO:0000723 xref: CALOHA:TS-0545 xref: EHDAA:9057 xref: EMAPA:17838 xref: EV:0100343 xref: FMA:58241 xref: MA:0000275 xref: MAT:0000141 xref: MESH:D007908 xref: MIAA:0000141 xref: NCIT:C12743 xref: RETIRED_EHDAA2:0000975 xref: SCTID:181169005 xref: TAO:0000035 xref: UMLS:C0023317 {source="ncithesaurus:Crystalline_Lens"} xref: VHOG:0000169 xref: Wikipedia:Lens_(anatomy) xref: XAO:0000008 xref: ZFA:0000035 is_a: UBERON:0005389 ! transparent eye structure relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball relationship: developmentally_induced_by UBERON:0003902 ! retinal neural layer relationship: develops_from UBERON:0005426 ! lens vesicle relationship: part_of UBERON:0001801 ! anterior segment of eyeball property_value: RO:0002171 UBERON:0002049 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000169", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "This class excludes compound eye corneal lenses." xsd:string [Term] id: UBERON:0000966 name: retina namespace: uberon def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [Wikipedia:Retina, ZFIN:curator] comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "inner layer of eyeball" EXACT [] synonym: "Netzhaut" RELATED [BTO:0001175] synonym: "retina of camera-type eye" EXACT [GO:0060041] synonym: "retinas" RELATED OMO:0003004 [ZFA:0000152] synonym: "tunica interna of eyeball" EXACT [] xref: AAO:0010352 xref: BAMS:R xref: BIRNLEX:1153 xref: BTO:0001175 xref: CALOHA:TS-0865 xref: EFO:0000832 xref: EHDAA2:0001627 xref: EHDAA:4757 xref: EMAPA:17168 xref: EV:0100348 xref: FMA:58301 xref: GAID:755 xref: MA:0000276 xref: MAT:0000142 xref: MBA:304325711 xref: MESH:D012160 xref: MIAA:0000142 xref: NCIT:C12343 xref: neuronames:1862 xref: NIFSTD_RETIRED:birnlex_1156 xref: SCTID:181171005 xref: TAO:0000152 xref: UMLS:C0035298 {source="BIRNLEX:1153", source="ncithesaurus:Retina"} xref: UMLS:C1278894 {source="BIRNLEX:1153"} xref: VHOG:0000229 xref: Wikipedia:Retina xref: XAO:0000009 xref: ZFA:0000152 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array relationship: develops_from UBERON:0003072 {source="EHDAA2"} ! optic cup relationship: has_part CL:0000573 {source="FMA"} ! retinal cone cell relationship: has_part CL:0000604 {source="FMA"} ! retinal rod cell relationship: has_part CL:0000740 {source="FMA"} ! retinal ganglion cell relationship: part_of UBERON:0001802 ! posterior segment of eyeball relationship: part_of UBERON:0019207 ! chorioretinal region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png xsd:anyURI property_value: RO:0002161 NCBITaxon:6656 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "retinal" xsd:string [Term] id: UBERON:0000970 name: eye namespace: uberon def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: uberon_slim synonym: "light-detecting organ" RELATED [] synonym: "visual apparatus" RELATED [EV:0100336] xref: BILA:0000017 xref: BTO:0000439 xref: CALOHA:TS-0309 xref: EFO:0000827 xref: EV:0100336 xref: FBbt:00005162 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:69 xref: MAT:0000140 xref: MESH:D005123 xref: MIAA:0000140 xref: Wikipedia:Eye is_a: UBERON:0000020 ! sense organ relationship: capable_of GO:0009584 ! detection of visible light relationship: has_part CL:0000149 {source="PMID:21062451"} ! visual pigment cell relationship: has_part CL:0000210 {source="PMID:21062451"} ! photoreceptor cell relationship: part_of UBERON:0002104 ! visual system property_value: IAO:0000232 "This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "ocular" xsd:string property_value: UBPROP:0000007 "optic" xsd:string property_value: UBPROP:0000010 "Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva," xsd:string [Term] id: UBERON:0000971 name: ommatidium namespace: uberon def: "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells." [PMID:21062451] subset: uberon_slim synonym: "omatidia" RELATED OMO:0003004 [] synonym: "omatidium" EXACT [] xref: BTO:0001922 xref: FBbt:00004510 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000666 xref: MAT:0000143 xref: MIAA:0000143 xref: Wikipedia:Ommatidium is_a: UBERON:0000970 {source="PMID:21062451"} ! eye is_a: UBERON:0002536 ! arthropod sensillum relationship: part_of UBERON:0000018 ! compound eye property_value: UBPROP:0000007 "ommatidial" xsd:string [Term] id: UBERON:0000974 name: neck namespace: uberon def: "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "collum" RELATED OMO:0003011 [Wikipedia:Neck] synonym: "neck (volume)" RELATED [FMA:7155] xref: AEO:0000108 xref: BTO:0000420 xref: CALOHA:TS-2045 xref: EFO:0000967 xref: EHDAA2:0003108 xref: EMAPA:35587 xref: FMA:7155 xref: GAID:86 xref: galen:Neck xref: MA:0000024 xref: MAT:0000297 xref: MESH:D009333 xref: MIAA:0000297 xref: NCIT:C13063 xref: SCTID:302550007 xref: UMLS:C0027530 {source="ncithesaurus:Neck"} xref: Wikipedia:Neck is_a: UBERON:0000475 ! organism subdivision relationship: anteriorly_connected_to UBERON:0000033 ! head relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0000153 ! anterior region of body relationship: posteriorly_connected_to UBERON:0002100 ! trunk property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg xsd:anyURI property_value: IAO:0000232 "true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck." xsd:string property_value: RO:0002174 NCBITaxon:32443 {source="ISBN:9780674021839"} property_value: UBPROP:0000007 "cervical" xsd:string [Term] id: UBERON:0000977 name: pleura namespace: uberon def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." [https://github.com/obophenotype/uberon/issues/1231, ISBN:0-683-40008-8, MP:0010820, UBERON:cjm, Wikipedia:Pulmonary_pleurae] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pleura" RELATED [] synonym: "pleural tissue" RELATED [BTO:0001791, NCIT:C12469] synonym: "wall of pleural sac" EXACT [] xref: BTO:0001791 xref: CALOHA:TS-2081 xref: EFO:0001980 xref: EV:0100044 xref: FMA:9583 xref: GAID:360 xref: MA:0000433 xref: MESH:D010994 xref: NCIT:C12469 xref: SCTID:181609007 xref: UMLS:C0032225 {source="ncithesaurus:Pleural_Tissue"} xref: VHOG:0000394 xref: Wikipedia:Pleura is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: has_part UBERON:0002400 ! parietal pleura intersection_of: has_part UBERON:0002401 ! visceral pleura intersection_of: part_of UBERON:0009778 ! pleural sac relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: has_part UBERON:0002400 ! parietal pleura relationship: has_part UBERON:0002401 ! visceral pleura relationship: has_quality PATO:0001748 ! invaginated relationship: in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0009778 {source="https://github.com/obophenotype/uberon/issues/86"} ! pleural sac property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png xsd:anyURI property_value: RO:0002175 NCBITaxon:8782 {source="ISBN:978-0030223693", source="https://orcid.org/0000-0003-3308-6245"} property_value: UBPROP:0000001 "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000394", ontology="VHOG", source="ISBN:0124020607", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pleural" xsd:string property_value: UBPROP:0000012 "In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86" xsd:string [Term] id: UBERON:0000982 name: skeletal joint namespace: uberon def: "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000101, Wikipedia:Joint] subset: efo_slim subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "articular joint" RELATED [BTO:0001686] synonym: "articulation" BROAD [VSAO:0000101] synonym: "joint" BROAD [FMA:7490, VSAO:0000101] synonym: "joints" RELATED OMO:0003004 [ZFA:0001596] xref: AEO:0000182 xref: BTO:0001686 xref: CALOHA:TS-2023 xref: EFO:0000948 xref: EMAPA:35456 xref: FMA:7490 xref: GAID:102 xref: galen:Joint xref: MA:0000319 xref: MAT:0000188 xref: MESH:D007596 xref: MIAA:0000188 xref: NCIT:C13044 xref: RETIRED_EHDAA2:0003182 xref: SCTID:302536002 xref: TAO:0000367 xref: UMLS:C0022417 {source="ncithesaurus:Joint"} xref: VHOG:0001276 xref: VSAO:0000101 xref: Wikipedia:Joint xref: XAO:0000171 xref: ZFA:0001596 is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint disjoint_from: UBERON:0001474 ! bone element relationship: connects UBERON:0004765 ! skeletal element relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system property_value: UBPROP:0000001 "Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000101", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000367", ontology="TAO", source="TAO:pem"} [Term] id: UBERON:0000988 name: pons namespace: uberon def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pons cerebri" RELATED OMO:0003011 [NeuroNames:547] synonym: "pons of Varolius" EXACT [] synonym: "pons Varolii" EXACT [ncithesaurus:Pons_Varolii] xref: BAMS:PONS xref: BAMS:Pons xref: BIRNLEX:733 xref: BM:Pons xref: BTO:0001101 xref: CALOHA:TS-0813 xref: DHBA:10661 xref: EFO:0001394 xref: EHDAA2:0004394 xref: EMAPA:17563 xref: EV:0100253 xref: FMA:67943 xref: GAID:578 xref: HBA:9131 xref: MA:0000204 xref: MAT:0000115 xref: MBA:771 xref: MESH:D011149 xref: MIAA:0000115 xref: NCIT:C12511 xref: neuronames:547 {source="BIRNLEX:733"} xref: SCTID:279103004 xref: UMLS:C0032639 {source="BIRNLEX:733", source="ncithesaurus:Pons_Varolii"} xref: UMLS:C1280999 {source="BIRNLEX:733"} xref: VHOG:0001176 xref: Wikipedia:Pons is_a: UBERON:0002616 ! regional part of brain relationship: contributes_to_morphology_of UBERON:0001895 ! metencephalon relationship: contributes_to_morphology_of UBERON:0002298 ! brainstem relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001895 {source="neuronames"} ! metencephalon relationship: part_of UBERON:0002298 ! brainstem property_value: editor_note "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png xsd:anyURI property_value: RO:0002174 NCBITaxon:7955 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pons"} property_value: UBPROP:0000003 "During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.474", source="http://bgee.unil.ch/"} [Term] id: UBERON:0000990 name: reproductive system namespace: uberon def: "Anatomical system that has as its parts the organs concerned with reproduction." [Wikipedia:Reproductive_system] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "animal reproductive system" RELATED [BTO:0000081] synonym: "genital system" NARROW [] synonym: "genital tract" RELATED [] synonym: "genitalia" NARROW OMO:0003004 [] synonym: "Geschlechtsorgan" RELATED [BTO:0000081] synonym: "organa genitalia" RELATED [BTO:0000081] synonym: "reproductive tissue" RELATED [BTO:0000081] synonym: "reproductive tract" RELATED [] synonym: "systemata genitalia" RELATED OMO:0003011 [Wikipedia:Reproductive_system] xref: AAO:0010258 xref: BILA:0000103 xref: BTO:0000081 xref: CALOHA:TS-1318 xref: EFO:0000809 xref: EHDAA2:0001603 xref: EHDAA:5923 xref: EMAPA:17381 xref: EV:0100100 xref: FBbt:00004857 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7160 xref: GAID:363 xref: HAO:0000374 xref: HAO:0000895 xref: MA:0000326 xref: MESH:D005835 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000305 xref: NCIT:C12841 xref: SCTID:278875001 xref: TAO:0000632 xref: UMLS:C1261210 {source="ncithesaurus:Reproductive_System"} xref: VHOG:0000182 xref: WBbt:0005747 xref: Wikipedia:Reproductive_system xref: XAO:0000142 xref: ZFA:0000632 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: capable_of_part_of GO:0022414 ! reproductive process disjoint_from: UBERON:0001004 ! respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of_part_of GO:0022414 ! reproductive process relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0000991 ! gonad property_value: editor_note "consider splitting genitalia from reproductive system" xsd:string property_value: http://purl.org/dc/terms/date 2022-06-10T18:22:34Z xsd:dateTime property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010258", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000182", ontology="VHOG", source="PMID:21672850 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across Bilateria. Integrative and Comparative Biology (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000202 FMA:75572 [Term] id: UBERON:0000991 name: gonad namespace: uberon def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [ISBN:0140512888, Wikipedia:Gonad, ZFA:0000413, ZFIN:curator] subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gonada" EXACT [] synonym: "gonads" RELATED OMO:0003004 [ZFA:0000413] xref: AAO:0000213 xref: BILA:0000123 xref: BSA:0000079 xref: BTO:0000534 xref: EMAPA:17383 xref: FMA:18250 xref: GAID:368 xref: HAO:0000379 xref: MA:0002420 xref: MESH:D006066 xref: NCIT:C12725 xref: SCTID:304623008 xref: TAO:0000413 xref: UMLS:C0018067 {source="ncithesaurus:Gonad"} xref: VHOG:0000397 xref: WBbt:0005175 xref: Wikipedia:Gonad xref: XAO:0003146 xref: ZFA:0000413 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: has_part CL:0000586 ! germ cell relationship: contains_process GO:0007276 ! gamete generation relationship: develops_from UBERON:0005564 ! gonad primordium relationship: has_part CL:0000586 ! germ cell property_value: UBPROP:0000001 "Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000213", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000413", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000397", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "gonadal" xsd:string property_value: UBPROP:0000012 "FMA xref is a 'general anatomical term'" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0000992 name: ovary namespace: uberon def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "animal ovary" EXACT [EFO:0000973] synonym: "female gonad" EXACT [] synonym: "female organism genitalia gonad" EXACT [OBOL:automatic] synonym: "female organism genitalia gonada" EXACT [OBOL:automatic] synonym: "female organism reproductive system gonad" EXACT [OBOL:automatic] synonym: "female organism reproductive system gonada" EXACT [OBOL:automatic] synonym: "female reproductive system gonad" EXACT [OBOL:automatic] synonym: "female reproductive system gonada" EXACT [OBOL:automatic] synonym: "genitalia of female organism gonad" EXACT [OBOL:automatic] synonym: "genitalia of female organism gonada" EXACT [OBOL:automatic] synonym: "gonad of female organism genitalia" EXACT [OBOL:automatic] synonym: "gonad of female organism reproductive system" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "gonad of genitalia of female organism" EXACT [OBOL:automatic] synonym: "gonad of reproductive system of female organism" EXACT [OBOL:automatic] synonym: "gonada of female organism genitalia" EXACT [OBOL:automatic] synonym: "gonada of female organism reproductive system" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "gonada of genitalia of female organism" EXACT [OBOL:automatic] synonym: "gonada of reproductive system of female organism" EXACT [OBOL:automatic] synonym: "ovaries" RELATED OMO:0003004 [] synonym: "ovarium" RELATED OMO:0003011 [Wikipedia:Ovary] synonym: "ovum-producing ovary" EXACT SENSU [GO:0061039] synonym: "reproductive system of female organism gonad" EXACT [OBOL:automatic] synonym: "reproductive system of female organism gonada" EXACT [OBOL:automatic] xref: AAO:0000371 xref: BILA:0000125 xref: BSA:0000080 xref: BTO:0000975 xref: CALOHA:TS-0730 xref: EFO:0000973 xref: EHDAA2:0001360 xref: EHDAA:8124 xref: EMAPA:17962 xref: EV:0100111 xref: FBbt:00004865 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7209 xref: GAID:367 xref: MA:0000384 xref: MESH:D010053 xref: MIAA:0000125 xref: NCIT:C12404 xref: SCTID:181464007 xref: TAO:0000403 xref: UMLS:C0029939 {source="ncithesaurus:Ovary"} xref: VHOG:0000251 xref: Wikipedia:Ovary xref: XAO:0000258 xref: ZFA:0000403 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: part_of UBERON:0000474 ! female reproductive system disjoint_from: UBERON:0009117 ! indifferent gonad relationship: develops_from UBERON:0009117 ! indifferent gonad relationship: in_lateral_side_of UBERON:0003975 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA-abduced-lr"} ! internal female genitalia relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000371", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Female reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000403", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000251", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "ovarian" xsd:string property_value: UBPROP:0000008 "Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" xsd:string {source="WP"} [Term] id: UBERON:0001003 name: skin epidermis namespace: uberon def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epidermis" BROAD [] synonym: "skin" BROAD [] synonym: "vertebrate epidermis" EXACT [] xref: AAO:0000143 xref: BTO:0000404 xref: CALOHA:TS-0283 xref: EFO:0000954 xref: EMAPA:17528 xref: EV:0100153 xref: FMA:70596 xref: GAID:932 xref: MA:0000153 xref: MAT:0000154 xref: MESH:D004817 xref: MIAA:0000154 xref: NCIT:C12708 xref: SCTID:361694003 xref: TAO:0000105 xref: UMLS:C0014520 {source="ncithesaurus:Epidermis"} xref: VHOG:0000077 xref: Wikipedia:Epidermis_(skin) xref: XAO:0000028 xref: ZFA:0000105 is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:0007376 ! outer epithelium intersection_of: part_of UBERON:0002097 ! skin of body relationship: adjacent_to UBERON:0002067 ! dermis relationship: developmentally_replaces UBERON:0003055 ! periderm relationship: part_of UBERON:0002097 ! skin of body property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000105", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship loss: subclass external integument structures (AAO:0000961)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO"} property_value: UBPROP:0000003 "(...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000077", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.71-72", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "epidermal" xsd:string property_value: UBPROP:0000008 "Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes)." xsd:string [Term] id: UBERON:0001004 name: respiratory system namespace: uberon def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "apparatus respiratorius" EXACT [] synonym: "apparatus respiratorius" RELATED [BTO:0000203] synonym: "Atmungssystem" RELATED [BTO:0000203] synonym: "respiratory system" EXACT [] synonym: "systema respiratorium" RELATED OMO:0003011 [Wikipedia:Respiratory_system] xref: AAO:0000541 xref: BTO:0000203 xref: CALOHA:TS-1319 xref: EFO:0000804 xref: EHDAA2:0001604 xref: EHDAA:2203 xref: EMAPA:16727 xref: EV:0100036 xref: FMA:7158 xref: GAID:78 xref: MA:0000327 xref: MAT:0000030 xref: MESH:D012137 xref: MIAA:0000030 xref: NCIT:C12779 xref: SCTID:278197002 xref: TAO:0000272 xref: UMLS:C0035237 {source="ncithesaurus:Respiratory_System"} xref: VHOG:0000202 xref: Wikipedia:Respiratory_system xref: XAO:0000117 xref: ZFA:0000272 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0003016 ! respiratory system process relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: in_taxon NCBITaxon:33213 ! Bilateria property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb xsd:anyURI property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000541", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000202", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001005 name: respiratory airway namespace: uberon def: "An airway through which respiratory air passes in organisms." [Wikipedia:Trachea] subset: grouping_class subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "airway" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "airways" BROAD OMO:0003004 [http://orcid.org/0000-0002-6601-2165] xref: SCTID:361380005 xref: Wikipedia:Trachea is_a: UBERON:0003103 ! compound organ is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0034874 ! air in respiratory system relationship: part_of UBERON:0001004 ! respiratory system property_value: IAO:0000232 "This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends" xsd:string [Term] id: UBERON:0001007 name: digestive system namespace: uberon def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [FB:gg, NLM:alimentary+system, Wikipedia:Digestive_system] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "alimentary system" RELATED [] synonym: "alimentary tract" RELATED [] synonym: "gastrointestinal system" RELATED [] synonym: "gut" RELATED [] xref: AAO:0000129 xref: BILA:0000082 xref: BTO:0000058 xref: CALOHA:TS-1293 xref: EFO:0000793 xref: FBbt:00005055 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7152 xref: GAID:278 xref: galen:DigestiveSystem xref: MA:0002431 xref: MAT:0000018 xref: MESH:D004064 xref: MIAA:0000018 xref: ncithesaurus:Digestive_System xref: SCTID:278859004 xref: TADS:0000170 xref: TAO:0000339 xref: WBbt:0005748 xref: Wikipedia:Digestive_system xref: XAO:0000125 xref: ZFA:0000339 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: capable_of GO:0022600 ! digestive system process disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0022600 ! digestive system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000129", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000007 "digestive" xsd:string property_value: UBPROP:0000012 "many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001008 name: renal system namespace: uberon def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [DOI:10.1371/journal.pone.0099864, GO:0072001] comment: EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "excretory system" BROAD [] synonym: "renal or urinary system" RELATED [EHDAA:5901] synonym: "renal/urinary system" RELATED [] synonym: "systema urinaria" EXACT [FMA:7159] synonym: "systema urinarium" EXACT [BTO:0003092] synonym: "urinary system" EXACT [] synonym: "urinary tract" EXACT [] xref: AAO:0010257 xref: BILA:0000015 xref: BTO:0001244 xref: BTO:0003092 xref: CALOHA:TS-1323 xref: EFO:0000803 xref: EHDAA2:0001601 xref: EHDAA:5901 xref: EMAPA:17366 xref: EV:0100095 xref: FBbt:00005056 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7159 xref: GAID:391 xref: galen:UrinaryTract xref: MA:0000325 xref: MAT:0000027 xref: MESH:D014551 xref: MIAA:0000027 xref: NCIT:C12413 xref: SCTID:362204003 xref: TADS:0000162 xref: TAO:0000163 xref: UMLS:C1508753 {source="ncithesaurus:Urinary_System"} xref: VHOG:0000723 xref: WBbt:0005736 xref: Wikipedia:Excretory_system xref: XAO:0000143 xref: ZFA:0000163 is_a: UBERON:8450002 ! excretory system intersection_of: UBERON:8450002 ! excretory system intersection_of: capable_of GO:0097254 ! renal tubular secretion relationship: capable_of GO:0097254 ! renal tubular secretion relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010257", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000723", ontology="VHOG", source="ISBN:978-3540428541 Kapoor BG, Bhavna Khanna, Ichthyology Handbook (2004) p.406", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels" xsd:string {source="GO"} property_value: UBPROP:0000008 "This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans" xsd:string {source="DOI:10.1371/journal.pone.0099864"} [Term] id: UBERON:0001009 name: circulatory system namespace: uberon def: "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [Wikipedia:Circulatory_system] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "systema cardiovasculare" RELATED OMO:0003011 [Wikipedia:Circulatory_system] xref: AAO:0000959 xref: CALOHA:TS-2103 xref: MESH:D002319 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: VHOG:0001248 xref: Wikipedia:Circulatory_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0003013 ! circulatory system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: in_taxon NCBITaxon:33213 ! Bilateria property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg xsd:anyURI property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002161 NCBITaxon:6073 property_value: RO:0002161 NCBITaxon:6157 property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"} property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001248", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.493", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001013 name: adipose tissue namespace: uberon def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adipose" RELATED [BTO:0001487] synonym: "bodyfat" RELATED [BTO:0001487] synonym: "fat" EXACT [MA:0000009] synonym: "fat tissue" EXACT [] synonym: "fatty depot" RELATED [] synonym: "fatty tissue" EXACT [] xref: AAO:0000001 xref: AEO:000020 xref: BTO:0001487 xref: CALOHA:TS-0013 xref: EFO:0000790 xref: EHDAA2:0003120 xref: EMAPA:35112 xref: EV:0100381 xref: FMA:20110 xref: GAID:920 xref: galen:FattyTissue xref: MA:0000009 xref: MAT:0000015 xref: MESH:D000273 xref: MIAA:0000015 xref: NCIT:C12472 xref: SCTID:55603005 xref: TAO:0002134 xref: UMLS:C0001527 {source="ncithesaurus:Adipose_Tissue"} xref: VHOG:0001284 xref: Wikipedia:Adipose_tissue xref: XAO:0003049 xref: ZFA:0005345 is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: composed_primarily_of CL:0000136 ! adipocyte disjoint_from: UBERON:0003714 ! neural tissue relationship: composed_primarily_of CL:0000136 ! adipocyte property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Connective tissue in which fat is stored.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002134", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO"} property_value: UBPROP:0000003 "Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001284", ontology="VHOG", source="DOI:10.1017/S0029665107005423 Haugen F, Drevon CA, The interplay between nutrients and the adipose tissue. The Proceedings of the Nutrition Society (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "adipose" xsd:string property_value: UBPROP:0000008 "In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen." xsd:string property_value: UBPROP:0000012 "in FMA this is dense irregular connective tissue" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001015 name: musculature namespace: uberon def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Muscular_system] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle group" EXACT [] synonym: "muscle system" RELATED [] synonym: "muscles" RELATED [] synonym: "muscles set" EXACT [] synonym: "musculature" EXACT [] synonym: "musculature system" RELATED [] synonym: "musculi" EXACT OMO:0003011 [FMA:32558, FMA:TA] synonym: "set of muscles" EXACT [FMA:32558] synonym: "set of skeletal muscles" EXACT [MA:0000165] xref: BTO:0000887 xref: EFO:0001949 xref: EMAPA:35577 xref: FMA:32558 xref: MA:0000165 xref: NCIT:C13056 xref: TAO:0000548 xref: UMLS:C0026845 {source="ncithesaurus:Muscle"} xref: VSAO:0005038 xref: WBbt:0005737 xref: Wikipedia:Muscular_system xref: ZFA:0000548 is_a: UBERON:0011216 ! organ system subdivision relationship: composed_primarily_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0000383 ! musculature of body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png xsd:anyURI property_value: RO:0002171 UBERON:0001474 property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001016 name: nervous system namespace: uberon def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nerve net" NARROW [Wikipedia:Nerve_net] synonym: "neurological system" EXACT [GO:0050877] synonym: "systema nervosum" RELATED OMO:0003011 [Wikipedia:Nervous_system] xref: AAO:0000324 xref: BILA:0000079 xref: BIRNLEX:844 xref: BTO:0001484 xref: CALOHA:TS-1313 xref: EFO:0000802 xref: EHDAA2:0001246 xref: EHDAA:826 xref: EMAPA:16469 xref: EV:0100162 xref: FBbt:00005093 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7157 xref: GAID:466 xref: MA:0000016 xref: MAT:0000026 xref: MESH:D009420 xref: MIAA:0000026 xref: NCIT:C12755 xref: neuronames:3236 xref: SCTID:278196006 xref: TAO:0000396 xref: UMLS:C0027763 {source="ncithesaurus:Nervous_System"} xref: VHOG:0000402 xref: WBbt:0005735 xref: Wikipedia:Nervous_system xref: XAO:0000177 xref: ZFA:0000396 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0050877 ! nervous system process relationship: composed_primarily_of CL:0002319 ! neural cell relationship: develops_from UBERON:0000922 ! embryo relationship: develops_from UBERON:0016880 ! future nervous system relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part CL:0000540 ! neuron relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png xsd:anyURI property_value: RO:0002161 NCBITaxon:6040 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "nervous" xsd:string property_value: UBPROP:0000007 "neural" xsd:string [Term] id: UBERON:0001017 name: central nervous system namespace: uberon def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [GO:0021551, http://www.frontiersinzoology.com/content/7/1/29, https://sourceforge.net/p/geneontology/ontology-requests/11422/] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebrospinal axis" NARROW [FMA:55675] synonym: "CNS" EXACT OMO:0003000 [] synonym: "neuraxis" RELATED [FMA:55675] synonym: "systema nervosum centrale" EXACT OMO:0003011 [FMA:55675, FMA:TA] xref: AAO:0000090 xref: BAMS:CNS xref: BILA:0000080 xref: BIRNLEX:1099 xref: BTO:0000227 xref: CALOHA:TS-0150 xref: EFO:0000908 xref: EHDAA2:0000225 xref: EHDAA:828 xref: EMAPA:16470 xref: EMAPA:16754 xref: EV:0100163 xref: FBbt:00005094 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:55675 xref: GAID:570 xref: MA:0000167 xref: MAT:0000457 xref: MESH:D002490 xref: NCIT:C12438 xref: neuronames:854 xref: SCTID:278199004 xref: TAO:0000012 xref: UMLS:C0927232 {source="ncithesaurus:Central_Nervous_System", source="BIRNLEX:1099"} xref: VHOG:0000293 xref: Wikipedia:Central_nervous_system xref: XAO:0000215 xref: ZFA:0000012 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 {source="FBbt", source="cjm"} ! organ system subdivision relationship: develops_from UBERON:0001049 {gci_relation="part_of", gci_filler="NCBITaxon:7742", evidence="definitional"} ! neural tube relationship: develops_from UBERON:0016879 ! future central nervous system relationship: develops_from UBERON:0016880 ! future nervous system relationship: immediate_transformation_of UBERON:0016879 {source="Bgee:AN"} ! future central nervous system relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of UBERON:0001016 ! nervous system property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Part of the nervous system which includes the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000090", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The brain and spinal cord. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000012", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO)." xsd:string {source="BIRNLEX:1099"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000293", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 (reference 1), ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 (reference 2), DOI:10.1016/j.cell.2007.02.040 Denes AS, Jekely G, Steinmetz PRH, Raible F, Snyman H, Prud'homme B, Ferrier DEK, Balavoine G and Arendt D, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in Bilateria. Cell (2007) (reference 3)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001021 name: nerve namespace: uberon def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nerves" EXACT OMO:0003004 [TAO:0007009] synonym: "neural subtree" RELATED [FMA:65132] synonym: "peripheral nerve" EXACT [http://orcid.org/0000-0002-6601-2165] xref: AAO:0011070 xref: AEO:0000137 xref: BAMS:n xref: BIRNLEX:1615 xref: BSA:0000098 xref: BTO:0000925 xref: BTO:0001027 xref: CALOHA:TS-0772 xref: EHDAA2:0003137 xref: EHDAA:2851 xref: EHDAA:3776 xref: EHDAA:4657 xref: EMAPA:32808 xref: EMAPA:32815 xref: EV:0100371 xref: FBbt:00005105 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:65132 xref: FMA:65239 xref: GAID:747 xref: GAID:758 xref: galen:Nerve xref: MA:0000217 xref: MA:0000228 xref: MESH:D010525 xref: NCIT:C12466 xref: NCIT:C12768 xref: NLX:147826 xref: SCTID:244457007 xref: SCTID:256864008 xref: TAO:0007009 xref: UMLS:C0027740 {source="ncithesaurus:Nerve"} xref: UMLS:C0031119 {source="ncithesaurus:Peripheral_Nerve"} xref: VHOG:0000901 xref: Wikipedia:Nervous_system xref: XAO:0000204 xref: XAO:0003047 xref: ZFA:0007009 is_a: UBERON:0000122 {source="FBbt"} ! neuron projection bundle relationship: has_developmental_contribution_from UBERON:0002342 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neural crest relationship: has_quality PATO:0002045 ! dendritic relationship: part_of UBERON:0000010 ! peripheral nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A portion of tissue which is a fasiculated group of axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007009", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000007 "nervous" xsd:string [Term] id: UBERON:0001027 name: sensory nerve namespace: uberon def: "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." [UBERON:cjm, Wikipedia:Sensory_nerve] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "afferent nerve" RELATED [] synonym: "nervus sensorius" EXACT OMO:0003011 [Wikipedia:Sensory_nerve] xref: AEO:0000201 xref: EHDAA2:0003200 xref: FBbt:00005136 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:5868 xref: Wikipedia:Sensory_nerve is_a: UBERON:0001021 ! nerve relationship: has_part CL:0000526 {source="AEO"} ! afferent neuron [Term] id: UBERON:0001032 name: sensory system namespace: uberon def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [Wikipedia:Sensory_system] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "organa sensuum" EXACT OMO:0003011 [FMA:75259, FMA:TA] synonym: "organa sensuum" RELATED OMO:0003011 [Wikipedia:Sensory_system] synonym: "sense organ subsystem" EXACT [] synonym: "sense organs" EXACT [FMA:75259] synonym: "sense organs set" EXACT [FMA:75259] synonym: "sensory organ system" RELATED [] synonym: "sensory subsystem" EXACT [] synonym: "sensory systems" EXACT OMO:0003004 [TAO:0000282] synonym: "set of sense organs" RELATED [FMA:75259] xref: AAO:0000555 xref: BAMS:SEN xref: BILA:0000099 xref: EFO:0000805 xref: EHDAA2:0003094 xref: EMAPA:16192 xref: FBbt:00007692 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:75259 xref: MA:0002442 xref: MAT:0000031 xref: MIAA:0000031 xref: NLXANAT:090816 xref: TAO:0000282 xref: VHOG:0001674 xref: Wikipedia:Sensory_system xref: XAO:0003194 xref: ZFA:0000282 is_a: UBERON:0015203 ! non-connected functional system relationship: capable_of_part_of GO:0007600 ! sensory perception relationship: overlaps UBERON:0001016 ! nervous system relationship: part_of UBERON:0004456 ! entire sense organ system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string [Term] id: UBERON:0001040 name: yolk sac namespace: uberon def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." [Wikipedia:Yolk_sac] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "saccus vitellinus" RELATED OMO:0003011 [Wikipedia:Yolk_sac] synonym: "vesicula umbilicalis" RELATED OMO:0003011 [Wikipedia:Yolk_sac] xref: BTO:0001471 xref: CALOHA:TS-1130 xref: EFO:0003078 xref: EHDAA2:0002212 xref: EHDAA:164 xref: EMAPA:16085 xref: FMA:87180 xref: GAID:1301 xref: MESH:D015017 xref: NCIT:C14128 xref: SCTID:362845002 xref: UMLS:C0043425 {source="ncithesaurus:Yolk_Sac"} xref: VHOG:0000830 xref: Wikipedia:Yolk_sac is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005631 {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://github.com/obophenotype/uberon/issues/635"} ! extraembryonic membrane is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac relationship: has_developmental_contribution_from UBERON:0000925 {source="ISBN:0073040584"} ! endoderm relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm property_value: editor_note "consider splitting class" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png xsd:anyURI property_value: UBPROP:0000001 "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/yolk+sac"} property_value: UBPROP:0000001 "the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" xsd:string {source="MP:0001718"} property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In therians, a structure homologous to the yolk sac is is present, but contains no yolk platelets. Instead it is filled with fluid [ISBN:0073040584 (Vertebrates, Kardong)]" xsd:string [Term] id: UBERON:0001041 name: foregut namespace: uberon def: "Anterior subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: developmental_classification subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "praeenteron" RELATED OMO:0003011 [Wikipedia:Foregut] synonym: "proenteron" RELATED OMO:0003011 [Wikipedia:Foregut] xref: AAO:0011042 xref: BILA:0000085 xref: BTO:0000507 xref: EHDAA2:0000557 xref: EHDAA:520 xref: EMAPA:16548 xref: FBbt:00005379 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45616 xref: MA:0001526 xref: NCIT:C34180 xref: SCTID:361409009 xref: TGMA:0001014 xref: UMLS:C0231051 {source="ncithesaurus:Foregut"} xref: VHOG:0000285 xref: Wikipedia:Foregut xref: XAO:0000232 is_a: UBERON:0004921 ! subdivision of digestive tract property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png xsd:anyURI property_value: UBPROP:0000001 "The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder." xsd:string {source="MP:0000474"} property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000285", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001042 name: chordate pharynx namespace: uberon def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [http://www.feedexp.org] comment: Consider generalizing to deuterostome pharynx subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pharynx" BROAD SENSU [FMA:46688] xref: AAO:0000967 xref: BTO:0001049 xref: CALOHA:TS-0785 xref: EFO:0000836 xref: EHDAA2:0001458 xref: EHDAA:2947 xref: EMAPA:16706 xref: EV:0100065 xref: FMA:46688 xref: GAID:155 xref: galen:Pharynx xref: MA:0000432 xref: MESH:D010614 xref: NCIT:C12425 xref: SCTID:181211006 xref: TAO:0000056 xref: UMLS:C0031354 {source="ncithesaurus:Pharynx"} xref: VHOG:0000462 xref: Wikipedia:Pharynx xref: XAO:0003227 xref: ZFA:0000056 is_a: UBERON:0006562 ! pharynx relationship: continuous_with UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus relationship: develops_from UBERON:0009145 {source="EHDAA2"} ! pharyngeal region of foregut relationship: distally_connected_to UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus relationship: has_skeleton UBERON:0008895 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! splanchnocranium relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0001004 ! respiratory system property_value: UBPROP:0000001 "A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867]." xsd:string {source="MESH:A03.867"} property_value: UBPROP:0000001 "Anatomical cavity bounded by the derivatives of the branchial arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000056", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576]." xsd:string {source="ZFIN:ZDB-PUB-961014-576"} property_value: UBPROP:0000001 "The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000462", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000002 "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO"} property_value: UBPROP:0000002 "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO"} property_value: UBPROP:0000003 "(...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000462", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) Box essay 13.1 and Box figure I, p.502-503", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001043 name: esophagus namespace: uberon def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [http://www.rivm.nl/interspeciesinfo/inter/oesophagus/, Wikipedia:Esophagus] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gullet" EXACT [] synonym: "oesophagus" EXACT [] xref: AAO:0000145 xref: ANISEED:1235301 xref: BTO:0000959 xref: CALOHA:TS-0700 xref: EFO:0000835 xref: EHDAA2:0001285 xref: EHDAA:2937 xref: EMAPA:16833 xref: EV:0100069 xref: FMA:7131 xref: GAID:291 xref: galen:Esophagus xref: MA:0000352 xref: MAT:0000048 xref: MESH:D004947 xref: MIAA:0000048 xref: NCIT:C12389 xref: SCTID:181245004 xref: TAO:0000204 xref: UMLS:C0014876 {source="ncithesaurus:Esophagus"} xref: VHOG:0000450 xref: Wikipedia:Esophagus xref: XAO:0000127 xref: ZFA:0000204 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0013765 ! digestive system element relationship: develops_from UBERON:0001041 ! foregut relationship: distally_connected_to UBERON:0000945 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="only in species that have a stomach"} ! stomach relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0004908 ! upper digestive tract relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000145", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000450", ontology="VHOG", source="DOI:10.1111/j.1096-3642.1996.tb01658.x Mallatt J, Ventilation and the origin of jawed vertebrates: a new mouth. Zoological Journal of the Linnean Society (1996)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "esophageal" xsd:string property_value: UBPROP:0000012 "esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001045 name: midgut namespace: uberon def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." [GO:0007494, Wikipedia:Midgut] subset: developmental_classification subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "mesenteron" RELATED OMO:0003011 [Wikipedia:Midgut] xref: BILA:0000086 xref: BTO:0000863 xref: EFO:0001950 xref: EHDAA2:0001185 xref: EHDAA:983 xref: EMAPA:16255 xref: FBbt:00005383 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45617 xref: MA:0001564 xref: NCIT:C34210 xref: SCTID:361410004 xref: TGMA:0001036 xref: UMLS:C0231052 {source="ncithesaurus:Midgut"} xref: VHOG:0000290 xref: Wikipedia:Midgut xref: XAO:0000103 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: part_of RO:0002577 ! system relationship: proximally_connected_to UBERON:0001041 ! foregut property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. We may explicitly make this a developmental class" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg xsd:anyURI property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000290", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon" xsd:string {source="WP"} property_value: UBPROP:0000012 "in FMA this represents an embryonic region." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001046 name: hindgut namespace: uberon def: "The caudalmost subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: developmental_classification subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "metenteron" RELATED OMO:0003011 [Wikipedia:Hindgut] xref: AAO:0011052 xref: BILA:0000087 xref: BTO:0000510 xref: EHDAA2:0000779 xref: EHDAA:975 xref: EMAPA:16715 xref: FBbt:00005384 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45618 xref: MA:0001527 xref: NCIT:C34188 xref: SCTID:362856002 xref: TGMA:0001020 xref: UMLS:C0231053 {source="ncithesaurus:Hindgut"} xref: VHOG:0000459 xref: Wikipedia:Hindgut xref: XAO:0000104 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: develops_from UBERON:0003104 {source="Wikipedia"} ! mesenchyme relationship: part_of RO:0002577 ! system relationship: proximally_connected_to UBERON:0001045 ! midgut property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future (vertebrates have some contribution from NC - https://github.com/obophenotype/uberon/wiki/The-neural-crest). We may explicitly make this a developmental class" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png xsd:anyURI property_value: UBPROP:0000001 "the caudal portion of the primitive digestive tube of the embryo" xsd:string {source="MP:0008786"} property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000459", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "in FMA this class has no children. In MA it has a single child hindgut epithelium" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001048 name: primordium namespace: uberon def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." [BTO:0001886, FB:DJS, FB:FBrf0089570, http://flybase.org/reports/FBrf0178740.html] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "bud" RELATED [] synonym: "future organ" RELATED [] synonym: "placode" RELATED [FBbt:00005495] synonym: "primordia" RELATED OMO:0003004 [XAO:0003043] synonym: "rudiment" RELATED [] xref: AEO:0000171 xref: BTO:0001886 xref: EFO:0001652 xref: EHDAA2:0003171 xref: FBbt:00005495 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:86589 xref: MAT:0000482 xref: NCIT:C34275 xref: UMLS:C0678727 {source="ncithesaurus:Primordium"} xref: Wikipedia:Primordium xref: XAO:0003043 is_a: UBERON:0005423 {source="EHDAA2"} ! developing anatomical structure relationship: part_of UBERON:0000468 ! multicellular organism [Term] id: UBERON:0001049 name: neural tube namespace: uberon def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [Wikipedia:Neural_tube] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "neural primordium" RELATED [] synonym: "presumptive central nervous system" RELATED [] synonym: "tubus neuralis" RELATED OMO:0003011 [Wikipedia:Neural_tube] xref: AAO:0010617 xref: BTO:0001057 xref: CALOHA:TS-2371 xref: DHBA:10154 xref: EHDAA2:0001254 xref: EHDAA:2869 xref: EHDAA:908 xref: EMAPA:16164 xref: EMAPA:16757 xref: FMA:293882 xref: MAT:0000069 xref: MESH:D054259 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: MIAA:0000069 xref: NCIT:C34226 xref: neuronames:1365 xref: SCTID:362852000 xref: TAO:0001135 xref: UMLS:C0231024 {source="ncithesaurus:Neural_Tube"} xref: VHOG:0000307 xref: Wikipedia:Neural_tube xref: XAO:0003204 xref: ZFA:0001135 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: develops_from UBERON:0005068 ! neural rod property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"} property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium" xsd:string {source="GO:0021915"} [Term] id: UBERON:0001052 name: rectum namespace: uberon def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "intestinum rectum" RELATED [BTO:0001158] synonym: "rectal sac" RELATED [] synonym: "terminal portion of intestine" EXACT [] synonym: "terminal portion of large intestine" RELATED [] xref: AAO:0010401 xref: BTO:0001158 xref: CALOHA:TS-1180 xref: EFO:0000848 xref: EHDAA2:0001592 xref: EHDAA:5836 xref: EMAPA:17896 xref: EV:0100081 xref: FMA:14544 xref: GAID:311 xref: galen:Rectum xref: MA:0000336 xref: MAT:0000050 xref: MESH:D012007 xref: MIAA:0000050 xref: NCIT:C12390 xref: SCTID:181261002 xref: UMLS:C0034896 {source="ncithesaurus:Rectum"} xref: VHOG:0001751 xref: Wikipedia:Rectum xref: XAO:0000238 is_a: UBERON:0004921 {order="4", source="cjm"} ! subdivision of digestive tract relationship: continuous_with UBERON:0001159 ! sigmoid colon relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine relationship: distalmost_part_of UBERON:0000059 {source="ISBN:0073040584"} ! large intestine relationship: part_of UBERON:0000059 {source="MA"} ! large intestine relationship: part_of UBERON:0006866 ! terminal part of digestive tract relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001751", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "rectal" xsd:string property_value: UBPROP:0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" xsd:string [Term] id: UBERON:0001062 name: anatomical entity namespace: uberon def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: human_subset subset: mouse_subset subset: upper_level xref: AAO:0010841 xref: AEO:0000000 xref: BFO:0000004 xref: BILA:0000000 xref: BIRNLEX:6 xref: CARO:0000000 xref: EHDAA2:0002229 xref: FBbt:10000000 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:62955 xref: HAO:0000000 xref: MA:0000001 xref: NCIT:C12219 xref: TAO:0100000 xref: TGMA:0001822 xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"} xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 is_a: BFO:0000004 ! independent continuant relationship: part_of UBERON:0003942 {gci_filler="GO:0050975", gci_relation="capable_of_part_of"} ! somatosensory system relationship: part_of UBERON:0003942 {gci_relation="capable_of_part_of", gci_filler="GO:0019233"} ! somatosensory system property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0001064 name: ventral pancreatic duct namespace: uberon alt_id: UBERON:0005627 def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct] comment: EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "canal of Wirsung" RELATED [BTO:0002362] synonym: "chief pancreatic duct" EXACT [FMA:16003] synonym: "duct of Wirsung" EXACT [Wikipedia:Pancreatic_duct] synonym: "ductus pancreatis ventralis" RELATED [] synonym: "hepaticopancreatic duct" RELATED [BTO:0002362] synonym: "main pancreatic duct" EXACT [MA:0000126] synonym: "pancreatic duct" BROAD [MESH:A03.734.667] xref: BTO:0002362 xref: EHDAA2:0001396 xref: EHDAA:6905 xref: EMAPA:17510 xref: FMA:16003 xref: GAID:337 xref: MA:0000126 xref: MESH:D010183 xref: NCIT:C12272 xref: RETIRED_EHDAA2:0002177 xref: SCTID:245385001 xref: UMLS:C0030288 {source="ncithesaurus:Pancreatic_Duct"} xref: VHOG:0000256 xref: Wikipedia:Pancreatic_duct is_a: UBERON:0000025 ! tube is_a: UBERON:0007329 {source="FMA"} ! pancreatic duct relationship: channel_for UBERON:0001970 ! bile relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla relationship: continuous_with UBERON:0001174 ! common bile duct relationship: develops_from UBERON:0003924 {source="EHDAA2"} ! ventral pancreatic bud property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000256", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." xsd:string {source="WP"} [Term] id: UBERON:0001068 name: skin of back namespace: uberon def: "A zone of skin that is part of a back [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "back skin" EXACT [] synonym: "back zone of skin" EXACT [OBOL:automatic] synonym: "skin, dorsal region" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zone of skin of back" EXACT [OBOL:automatic] xref: EMAPA:36392 xref: FMA:10462 xref: FMA:22985 xref: MA:0000498 xref: SCTID:181492002 is_a: UBERON:0001085 {source="MA"} ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0011270 {source="MA"} ! dorsal trunk [Term] id: UBERON:0001070 name: external carotid artery namespace: uberon def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteria carotis externa" RELATED OMO:0003011 [Wikipedia:External_carotid_artery] synonym: "external carotid" EXACT [AAO:0010218] xref: AAO:0010218 xref: AAO:0010416 xref: BTO:0004696 xref: EFO:0001953 xref: EHDAA2:0000461 xref: EMAPA:18611 xref: FMA:10635 xref: GAID:480 xref: MA:0001929 xref: MESH:D002342 xref: NCIT:C32551 xref: SCTID:362044002 xref: UMLS:C0007275 {source="ncithesaurus:External_Carotid_Artery"} xref: VHOG:0000265 xref: Wikipedia:External_carotid_artery xref: XAO:0000345 is_a: UBERON:0005396 {source="MA"} ! carotid artery segment relationship: branching_part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches relationship: develops_from UBERON:0001530 {source="EHDAA2"} ! common carotid artery plus branches relationship: part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722 xsd:anyURI property_value: UBPROP:0000008 "not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO" xsd:string [Term] id: UBERON:0001071 name: superficial cervical artery namespace: uberon def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery] comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "superficial branch of transverse cervical artery" EXACT [Wikipedia:Superficial_part_of_transverse_cervical_artery] xref: EMAPA:37117 {source="MA:th"} xref: FMA:10665 xref: MA:0002052 xref: NCIT:C53005 xref: SCTID:161746006 xref: UMLS:C0226271 {source="ncithesaurus:Superficial_Cervical_Artery"} xref: Wikipedia:Superficial_part_of_transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: part_of UBERON:0035549 ! vasculature of integument relationship: connected_to UBERON:0012324 ! transverse cervical artery relationship: part_of UBERON:0035549 ! vasculature of integument property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001072 name: inferior vena cava namespace: uberon def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "caudal vena cava" RELATED [VHOG:0001194] synonym: "inferior caval vein" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "postcava" RELATED [] synonym: "posterior vena cava" EXACT [PMID:21154280] synonym: "vena cava inferior" RELATED OMO:0003011 [BTO:0002682, Wikipedia:Inferior_vena_cava] xref: AAO:0011083 xref: BTO:0002682 xref: EHDAA2:0000611 xref: EMAPA:18416 xref: FMA:10951 xref: GAID:548 xref: galen:InferiorVenaCava xref: MA:0000480 xref: MESH:D014682 xref: NCIT:C12815 xref: SCTID:181369003 xref: UMLS:C0042458 {source="ncithesaurus:Inferior_Vena_Cava"} xref: VHOG:0001194 xref: Wikipedia:Inferior_vena_cava xref: XAO:0000388 is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: vessel_drains_blood_from UBERON:0000154 ! posterior region of body disjoint_from: UBERON:0001585 {source="lexical"} ! anterior vena cava relationship: channels_into UBERON:0002078 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! right cardiac atrium relationship: connected_to UBERON:0002078 ! right cardiac atrium relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0000154 ! posterior region of body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." xsd:string {source="FMA:10951"} property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001194", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001073 name: ileocecal junction namespace: uberon def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539] subset: human_subset subset: mouse_subset synonym: "ileocaecal junction" EXACT [] xref: EMAPA:37601 {source="MA:th"} xref: FMA:11338 xref: MA:0000332 xref: SCTID:264021000 is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: connects UBERON:0000059 ! large intestine intersection_of: connects UBERON:0002108 ! small intestine relationship: connects UBERON:0000059 ! large intestine relationship: connects UBERON:0002108 ! small intestine relationship: in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0001074 name: pericardial cavity namespace: uberon def: "A potential space between the visceral and parietal layers of the pericardium." [Wikipedia:Pericardium] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cavitas pericardiaca" RELATED OMO:0003011 [Wikipedia:Pericardial_cavity] synonym: "cavity of pericardial sac" EXACT [] synonym: "pericardial space" EXACT [Wikipedia:Pericardial_cavity] xref: BSA:0000091 xref: EHDAA2:0001434 xref: EMAPA:16131 xref: EMAPA:16132 xref: FMA:11350 xref: galen:PericardialSpace xref: MA:0000053 xref: NCIT:C38662 xref: SCTID:362027001 xref: TAO:0002220 xref: UMLS:C0225972 {source="ncithesaurus:Pericardial_Cavity"} xref: VHOG:0000556 xref: Wikipedia:Pericardial_cavity xref: ZFA:0001655 is_a: UBERON:0002323 {source="MA"} ! coelemic cavity lumen is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: luminal_space_of UBERON:0002406 ! pericardial sac relationship: develops_from UBERON:0003887 {source="Wikipedia"} ! intraembryonic coelom relationship: location_of UBERON:0002409 ! pericardial fluid relationship: luminal_space_of UBERON:0002406 ! pericardial sac relationship: part_of UBERON:0002406 {source="FMA"} ! pericardial sac relationship: surrounded_by UBERON:0002357 ! serous pericardium property_value: UBPROP:0000001 "Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002220", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000556", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal)" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0001081 name: endocardium of ventricle namespace: uberon def: "Endocardium that is part of the cardiac ventricle." [ZFIN:curator] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "cardiac ventricle endocardium" EXACT [OBOL:automatic] synonym: "endocardium of cardiac ventricle" EXACT [OBOL:automatic] synonym: "endocardium of heart ventricle" EXACT [OBOL:automatic] synonym: "endocardium of lower chamber of heart" EXACT [OBOL:automatic] synonym: "endocardium of ventricle of heart" EXACT [OBOL:automatic] synonym: "heart ventricle endocardium" EXACT [OBOL:automatic] synonym: "lower chamber of heart endocardium" EXACT [OBOL:automatic] synonym: "ventricle endocardial tissue" RELATED [VHOG:0000607] synonym: "ventricle endocardium" EXACT [] synonym: "ventricle of heart endocardium" EXACT [OBOL:automatic] synonym: "ventricular endocardium" EXACT [] xref: EMAPA:32747 xref: FMA:12148 xref: MA:0000079 xref: SCTID:192172004 xref: TAO:0002247 xref: VHOG:0000607 xref: ZFA:0001615 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: contributes_to_morphology_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! heart ventricle wall [Term] id: UBERON:0001082 name: epicardium of ventricle namespace: uberon def: "An epicardial layer that lines a cardiac ventricle." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "cardiac ventricle epicardium" EXACT [OBOL:automatic] synonym: "ventricular epicardium" EXACT [] xref: FMA:12150 xref: TAO:0005058 xref: ZFA:0005058 is_a: UBERON:0002348 ! epicardium intersection_of: UBERON:0002348 ! epicardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle property_value: UBPROP:0000001 "The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005058", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001083 name: myocardium of ventricle namespace: uberon def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [ZFIN:curator] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "ventricle cardiac muscle" RELATED [VHOG:0000604] synonym: "ventricle myocardium" EXACT [] synonym: "ventricular myocardium" EXACT [] xref: EFO:0003088 xref: EMAPA:32748 xref: FMA:12151 xref: MA:0000082 xref: SCTID:192084000 xref: TAO:0005061 xref: VHOG:0000604 xref: ZFA:0005061 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: contributes_to_morphology_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! heart ventricle wall property_value: UBPROP:0000001 "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005061", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000604", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001084 name: skin of head namespace: uberon def: "A zone of skin that is part of a head [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region subset: human_subset subset: mouse_subset synonym: "adult head zone of skin" EXACT [OBOL:automatic] synonym: "head skin" EXACT [] synonym: "head zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of adult head" EXACT [OBOL:automatic] synonym: "zone of skin of head" EXACT [OBOL:automatic] xref: FMA:12166 xref: FMA:24756 xref: MA:0000582 xref: NCIT:C52757 xref: SCTID:181484006 xref: UMLS:C0205029 {source="ncithesaurus:Head_Skin"} is_a: UBERON:0012180 ! head or neck skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0001085 name: skin of trunk namespace: uberon def: "A zone of skin that is part of a trunk [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region subset: human_subset subset: mouse_subset synonym: "torso zone of skin" EXACT [OBOL:automatic] synonym: "trunk skin" EXACT [] synonym: "trunk zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of torso" EXACT [OBOL:automatic] synonym: "zone of skin of trunk" EXACT [OBOL:automatic] xref: EMAPA:37278 {source="MA:th"} xref: FMA:12167 xref: FMA:23093 xref: MA:0000517 xref: NCIT:C12295 xref: SCTID:181489001 xref: UMLS:C0205031 {source="ncithesaurus:Skin_of_the_Trunk"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0001087 name: pleural fluid namespace: uberon def: "Transudate contained in the pleural cavity." [FMA:12273] subset: human_subset subset: mouse_subset subset: uberon_slim xref: BTO:0003080 xref: FMA:12273 xref: MA:0002532 xref: MAT:0000500 xref: ncithesaurus:Pleural_Fluid xref: Wikipedia:Pleural_fluid is_a: UBERON:0036244 ! secretion of serous membrane intersection_of: UBERON:0007779 ! transudate intersection_of: located_in UBERON:0002402 ! pleural cavity relationship: located_in UBERON:0002402 ! pleural cavity [Term] id: UBERON:0001090 name: synovial fluid namespace: uberon def: "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." [https://www.ncbi.nlm.nih.gov/books/NBK274/] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "joint fluid" EXACT [https://www.ncbi.nlm.nih.gov/books/NBK274/] xref: BTO:0001339 xref: CALOHA:TS-0996 xref: ENVO:02000039 xref: FMA:12277 xref: GAID:265 xref: galen:SynovialFluid xref: MA:0002544 xref: MESH:D013582 xref: NCIT:C33718 xref: TAO:0005154 xref: UMLS:C0039097 {source="ncithesaurus:Synovial_Fluid"} xref: Wikipedia:Synovial_fluid xref: ZFA:0005154 is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland intersection_of: UBERON:0007779 ! transudate intersection_of: produced_by CL:0000214 ! synovial cell relationship: has_part CHEBI:16336 ! hyaluronic acid relationship: located_in UBERON:0007617 ! synovial cavity of joint relationship: produced_by CL:0000214 ! synovial cell property_value: UBPROP:0000001 "Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005154", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000009 "It provides nutrients and lubrication for articular cartilage" xsd:string property_value: UBPROP:0000010 "The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma" xsd:string [Term] id: UBERON:0001092 name: vertebral bone 1 namespace: uberon def: "The first vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atlas" EXACT [] synonym: "atlas (CI)" EXACT [] synonym: "atlas [C I]" EXACT OMO:0003011 [FMA:12519, FMA:TA] synonym: "atlas vertebra" EXACT [] synonym: "C1" BROAD [] synonym: "C1 vertebra" EXACT [] synonym: "cervical atlas" EXACT [MP:0011576] synonym: "cervical vertebra 1" EXACT HUMAN_PREFERRED [MA:0001421] synonym: "first cervical vertebra" EXACT [] synonym: "vertebra 1" EXACT [TAO:0001167] xref: AAO:0000709 xref: EHDAA:10606 xref: EMAPA:19431 xref: FMA:12519 xref: GAID:236 xref: MA:0001421 xref: MESH:D001270 xref: NCIT:C32239 xref: SCTID:181818007 xref: TAO:0001167 xref: UMLS:C0004170 {source="ncithesaurus:C1_Vertebra"} xref: Wikipedia:Atlas_(anatomy) xref: ZFA:0001167 is_a: UBERON:0002412 ! vertebra relationship: anterior_to UBERON:0001093 ! vertebral bone 2 relationship: anteriorly_connected_to UBERON:0001676 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! occipital bone relationship: part_of UBERON:0006072 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! cervical region of vertebral column property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000709", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} property_value: UBPROP:0000001 "Vertebra that is posteriorly adjacent to the neurocranium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001167", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000107 "1" xsd:nonNegativeInteger [Term] id: UBERON:0001093 name: vertebral bone 2 namespace: uberon def: "The second vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "axis" RELATED INCONSISTENT [MA:0001422] synonym: "axis (CII)" EXACT [] synonym: "axis [C II]" EXACT OMO:0003011 [FMA:12520, FMA:TA] synonym: "axis vertebra" EXACT [] synonym: "C2" RELATED [] synonym: "C2 vertebra" NARROW [] synonym: "cervical axis" EXACT [MP:0004608] synonym: "cervical vertebra 2" NARROW HUMAN_PREFERRED [MA:0001422] synonym: "second cervical vertebra" NARROW [] synonym: "vertebra 2" EXACT [ZFA:0001168] xref: EHDAA:10608 xref: EMAPA:19432 xref: FMA:12520 xref: GAID:237 xref: MA:0001422 xref: MESH:D001368 xref: NCIT:C32240 xref: SCTID:181819004 xref: TAO:0001168 xref: UMLS:C0004457 {source="ncithesaurus:C2_Vertebra"} xref: Wikipedia:Axis_(anatomy) xref: ZFA:0001168 is_a: UBERON:0002412 ! vertebra relationship: anteriorly_connected_to UBERON:0001092 {source="FMA"} ! vertebral bone 1 relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0006072 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! cervical region of vertebral column property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vertebra that is posteriorly adjacent to vertebra 1.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001168", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000013 "not the same as ZFA term 'axis'" xsd:string property_value: UBPROP:0000107 "2" xsd:nonNegativeInteger [Term] id: UBERON:0001095 name: caudal vertebra namespace: uberon alt_id: UBERON:0006070 def: "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] comment: Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "caudal vertebra" BROAD SENSU [FMA:12527] synonym: "caudal vertebrae" EXACT OMO:0003004 [] synonym: "caudal vertebral bone" EXACT [] synonym: "caudal vertebral bone element" EXACT [] synonym: "coccygea" RELATED [MA:0001420] synonym: "coccygeal segment" EXACT [] synonym: "coccygeal vertebra" EXACT [FMA:12527] synonym: "fused tail vertebra" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tail vertebra" RELATED [MA:0000310] xref: EMAPA:18374 xref: FMA:12527 xref: galen:CoccygealVertebra xref: MA:0000310 xref: MA:0001420 xref: NCIT:C32334 xref: SCTID:361774004 xref: TAO:0000326 xref: UMLS:C0223616 {source="ncithesaurus:Coccygeal_Vertebra"} xref: Wikipedia:Caudal_vertebra xref: XAO:0003079 xref: ZFA:0000326 is_a: UBERON:0002412 ! vertebra is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000326", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000012 "we deliberately merge the MA classes as we believe them equivalent" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001096 name: wall of esophagus namespace: uberon def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anatomical wall of esophagus" EXACT [OBOL:automatic] synonym: "anatomical wall of gullet" EXACT [OBOL:automatic] synonym: "anatomical wall of oesophagus" EXACT [OBOL:automatic] synonym: "esophageal wall" EXACT [] synonym: "esophagus anatomical wall" EXACT [OBOL:automatic] synonym: "esophagus wall" EXACT [] synonym: "gullet anatomical wall" EXACT [OBOL:automatic] synonym: "gullet wall" EXACT [OBOL:automatic] synonym: "oesophagus anatomical wall" EXACT [OBOL:automatic] synonym: "oesophagus wall" EXACT [OBOL:automatic] synonym: "wall of gullet" EXACT [OBOL:automatic] synonym: "wall of oesophagus" EXACT [OBOL:automatic] xref: EMAPA:35326 xref: FMA:12611 xref: MA:0002691 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus [Term] id: UBERON:0001103 name: diaphragm namespace: uberon def: "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." [MP:0002279] subset: efo_slim subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "diaphragm muscle" EXACT [BTO:0000341] synonym: "diaphragm of thorax" EXACT [] synonym: "midriff" RELATED [BTO:0000341] synonym: "phren" RELATED [BTO:0000341] synonym: "thoracic diaphragm" EXACT [] xref: BTO:0000341 xref: CALOHA:TS-0198 xref: EFO:0000937 xref: EHDAA2:0003495 xref: EMAPA:17701 xref: EV:0100376 xref: FMA:13295 xref: GAID:158 xref: MA:0001904 xref: MAT:0000502 xref: MESH:D003964 xref: NCIT:C12702 xref: SCTID:181614006 xref: UMLS:C0011980 {source="ncithesaurus:Diaphragm"} xref: VHOG:0000713 xref: Wikipedia:Thoracid_diaphragm is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: develops_from UBERON:0010084 ! future diaphragm relationship: immediate_transformation_of UBERON:0010084 {evidence="definitional"} ! future diaphragm relationship: in_taxon NCBITaxon:40674 {source="PMID:23586979"} ! Mammalia relationship: innervated_by UBERON:0001884 ! phrenic nerve property_value: RO:0002161 NCBITaxon:8782 {source="Wikipedia:Thoracic_diaphragm#Comparative_anatomy_and_evolution"} property_value: UBPROP:0000001 "The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs[GO]." xsd:string {source="GO:0060539"} property_value: UBPROP:0000003 "The mammals are characterized by a diaphragm, which separates the thoracic portion of the body cavity from the abdominal region and assists in drawing air into the lungs and forcing it out. Modern reptiles lack a muscular diaphragm and it is reasonable to suppose that the diaphragm developed as a new device that made possible a large degree of oxygen intake for active animals. The change may have taken place during the transition from reptile to mammal (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000713", ontology="VHOG", source="ISBN:978-0471384618 Colbert EH, Evolution of the vertebrates: a history of the backboned animals through time (2001) p.278", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "phrenic" xsd:string property_value: UBPROP:0000008 "The existence of some membrane separating the pharynx from the stomach can be traced widely among the chordates. Thus amphioxus possesses an atrium by which water exits the pharynx, which has been argued (and disputed) to be homologous to structures in ascidians and hagfishes.[3]" xsd:string property_value: UBPROP:0000008 "The urochordate epicardium separates digestive organs from the pharynx and heart, but the anus returns to the upper compartment to discharge wastes through an outgoing siphon (Thoracic_diaphragm#Comparative_anatomy_and_evolution)" xsd:string property_value: UBPROP:0000009 "barrier between thoracic and abdominal cavities; stop gastric contents from refluxing into the oesophagus" xsd:string property_value: UBPROP:0000009 "breathing control" xsd:string property_value: UBPROP:0000011 "originate from the cervical somites, likely C3-C5[PMID:23586979]" xsd:string [Term] id: UBERON:0001113 name: lobe of liver namespace: uberon def: "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." [Wikipedia:Liver#Lobes] subset: human_subset subset: mouse_subset synonym: "hepatic lobe" EXACT [] synonym: "liver lobe" EXACT [] synonym: "lobus hepatis" EXACT [] xref: EMAPA:18306 xref: FMA:13361 xref: MA:0000360 xref: NCIT:C49579 xref: SCTID:245378000 xref: UMLS:C0447541 {source="ncithesaurus:Liver_Lobe"} xref: Wikipedia:Liver#Lobes is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe relationship: part_of UBERON:0002107 ! liver property_value: editor_note "some work needs to be done to ensure the child terms of this class have correct isa/partof placement. in MA they are subclasses, in FMA they are parts" xsd:string [Term] id: UBERON:0001114 name: right lobe of liver namespace: uberon def: "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." [Wikipedia:Right_lobe_of_liver] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "2nd lobe" RELATED [TAO:0005173] synonym: "gall bladder lobe" RELATED SENSU [ZFA:0005173] synonym: "liver right lobe" EXACT [] synonym: "lobus hepaticus dexter" EXACT OMO:0003011 [] synonym: "lobus hepatis dexter" RELATED OMO:0003011 [Wikipedia:Right_lobe_of_liver] synonym: "right hepatic lobe" RELATED [EMAPA:18311] synonym: "right liver lobe" EXACT [ZFA:0005173] synonym: "second lobe" RELATED [TAO:0005173] xref: EHDAA2:0001008 xref: EHDAA:4001 xref: EMAPA:18311 xref: FMA:13362 xref: MA:0000363 xref: NCIT:C33481 xref: SCTID:362182008 xref: TAO:0005173 xref: UMLS:C0227481 {source="ncithesaurus:Right_Lobe_of_the_Liver"} xref: VHOG:0001424 xref: Wikipedia:Right_lobe_of_liver xref: ZFA:0005173 is_a: UBERON:0001113 ! lobe of liver property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb xsd:anyURI property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005173", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001115 name: left lobe of liver namespace: uberon def: "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." [Wikipedia:Left_lobe_of_liver] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "left hepatic lobe" RELATED [EMAPA:18307] synonym: "left liver lobe" EXACT [] synonym: "liver left lobe" EXACT [] synonym: "lobus hepaticus sinister" EXACT OMO:0003011 [] synonym: "lobus hepatis sinister" RELATED OMO:0003011 [Wikipedia:Left_lobe_of_liver] xref: EHDAA2:0001000 xref: EHDAA:3995 xref: EMAPA:18307 xref: FMA:13363 xref: MA:0000361 xref: NCIT:C32965 xref: SCTID:362183003 xref: TAO:0005172 xref: UMLS:C0227486 {source="ncithesaurus:Left_Lobe_of_the_Liver"} xref: VHOG:0001423 xref: Wikipedia:Left_lobe_of_liver xref: ZFA:0005172 is_a: UBERON:0001113 ! lobe of liver property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb xsd:anyURI property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's left side.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005172", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001130 name: vertebral column namespace: uberon def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941, VSAO:0000185] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "backbone" NARROW [FMA:13478] synonym: "columna vertebralis" RELATED [BTO:0000818] synonym: "dorsal spine" RELATED [BTO:0000818] synonym: "spinal column" RELATED [MESH:A02.835.232.834] synonym: "spine" BROAD [FMA:13478] synonym: "vertebral column skeleton" NARROW [AAO:0000699] synonym: "vertebral region" RELATED [] xref: AAO:0000699 xref: AAO:0000734 xref: BTO:0000818 xref: EFO:0001369 xref: EHDA:10119 xref: EMAPA:35919 xref: FMA:13478 xref: GAID:106 xref: galen:SpinalColumn xref: MA:0002416 xref: MESH:D013131 xref: NCIT:C12998 xref: NCIT:C33588 xref: NIF_Subcellular:sao1145756102 xref: SCTID:44300000 xref: TAO:0001559 xref: UMLS:C0037949 {source="ncithesaurus:Vertebral_Column"} xref: UMLS:C1519455 {source="ncithesaurus:Spinal_Cord_Column"} xref: VHOG:0001142 xref: VSAO:0000185 xref: Wikipedia:Vertebral_column xref: XAO:0003074 xref: ZFA:0001559 is_a: UBERON:0000075 ! subdivision of skeletal system intersection_of: UBERON:0000075 ! subdivision of skeletal system intersection_of: composed_primarily_of UBERON:0010913 ! vertebral element relationship: composed_primarily_of UBERON:0010913 ! vertebral element relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0011138 {source="cjm"} ! postcranial axial skeletal system relationship: protects UBERON:0002240 ! spinal cord property_value: editor_note "Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton" xsd:string property_value: RO:0002161 NCBITaxon:7762 property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical cluster that consists of all the vertebra in the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000185", ontology="VSAO", source="VSAO:curator"} property_value: UBPROP:0000001 "The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001142", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vertebral+column"} property_value: UBPROP:0000003 "Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001142", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.53", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001131 name: vertebral foramen namespace: uberon def: "A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Vertebral_foramen] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "foramen vertebrale" RELATED OMO:0003011 [Wikipedia:Vertebral_foramen] synonym: "vertebra neural canal" EXACT [] xref: AAO:0000729 xref: EMAPA:37803 {source="MA:th"} xref: FMA:13479 xref: MA:0001454 xref: SCTID:280734009 xref: Wikipedia:Vertebral_foramen is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: conduit_for UBERON:0002240 ! spinal cord intersection_of: lumen_of UBERON:0010913 ! vertebral element relationship: conduit_for UBERON:0002240 ! spinal cord relationship: lumen_of UBERON:0010913 ! vertebral element relationship: part_of UBERON:0006692 ! vertebral canal relationship: part_of UBERON:0010913 ! vertebral element property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png xsd:anyURI property_value: UBPROP:0000001 "Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000729", ontology="AAO", source="AAO:LAP"} [Term] id: UBERON:0001133 name: cardiac muscle tissue namespace: uberon alt_id: UBERON:0007096 def: "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." [ZFA:0005280] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac muscle" EXACT [] synonym: "cardiac muscle muscle tissue" EXACT [OBOL:automatic] synonym: "cardiac muscle textus muscularis" EXACT [OBOL:automatic] synonym: "cardiac musculature" RELATED [BILA:0000134] synonym: "heart muscle muscle tissue" EXACT [OBOL:automatic] synonym: "heart muscle textus muscularis" EXACT [OBOL:automatic] synonym: "heart myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "heart myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "muscle of heart muscle tissue" EXACT [OBOL:automatic] synonym: "muscle of heart textus muscularis" EXACT [OBOL:automatic] synonym: "muscle tissue of cardiac muscle" EXACT [OBOL:automatic] synonym: "muscle tissue of heart muscle" EXACT [OBOL:automatic] synonym: "muscle tissue of heart myocardium" EXACT [OBOL:automatic] synonym: "muscle tissue of muscle of heart" EXACT [OBOL:automatic] synonym: "muscle tissue of myocardium" EXACT [OBOL:automatic] synonym: "myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "textus muscularis of cardiac muscle" EXACT [OBOL:automatic] synonym: "textus muscularis of heart muscle" EXACT [OBOL:automatic] synonym: "textus muscularis of heart myocardium" EXACT [OBOL:automatic] synonym: "textus muscularis of muscle of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium" EXACT [OBOL:automatic] xref: AAO:0010245 xref: AEO:0000142 xref: BILA:0000134 xref: BTO:0000199 xref: CALOHA:TS-0440 xref: EHDAA2:0003142 xref: EMAPA:32688 xref: FMA:14068 xref: galen:CardiacMuscle xref: galen:CardiacMuscleTissue xref: ncithesaurus:Heart_Muscle xref: TAO:0005280 xref: Wikipedia:Cardiac_muscle xref: ZFA:0005280 is_a: UBERON:8600006 ! visceral striated muscle tissue intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: has_part CL:0000746 ! cardiac muscle cell disjoint_from: UBERON:0001134 ! skeletal muscle tissue relationship: composed_primarily_of CL:0000746 ! cardiac muscle cell relationship: has_part CL:0000746 ! cardiac muscle cell relationship: part_of UBERON:0007100 ! primary circulatory organ property_value: editor_note "check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit" xsd:string [Term] id: UBERON:0001134 name: skeletal muscle tissue namespace: uberon def: "Muscle tissue that consists primarily of skeletal muscle fibers." [https://github.com/obophenotype/uberon/issues/324] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "skeletal muscle" BROAD [] synonym: "skeletal muscle system" RELATED [BTO:0001103] synonym: "somatic muscle" RELATED [BTO:0001103] xref: EMAPA:32716 xref: FMA:14069 xref: MA:0002439 xref: NCIT:C13050 xref: SCTID:426215008 xref: UMLS:C0242692 {source="ncithesaurus:Skeletal_Muscle_Tissue"} xref: Wikipedia:Skeletal_striated_muscle is_a: UBERON:0002036 ! striated muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: composed_primarily_of CL:0008002 ! skeletal muscle fiber relationship: composed_primarily_of CL:0008002 ! skeletal muscle fiber relationship: develops_from UBERON:0003082 ! myotome relationship: part_of UBERON:0014892 ! skeletal muscle organ, vertebrate property_value: editor_note "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/dosumis property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mellybelly property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/RDruzinsky property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg xsd:anyURI property_value: UBPROP:0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005277", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" xsd:string {external_class="FMA:14069", ontology="FMA"} property_value: UBPROP:0000003 "This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000319", ontology="VHOG", source="PMID:10368962 Oota S, Saitou N, Phylogenetic relationship of muscle tissues deduced from superimposition of gene trees. Mol Biol Evol (1999)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001135 name: smooth muscle tissue namespace: uberon def: "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." [GO:0006939, Wikipedia:Smooth_muscle_tissue] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "involuntary muscle" EXACT [] synonym: "non-striated muscle" EXACT [] synonym: "smooth muscle" EXACT [] synonym: "textus muscularis levis; textus muscularis nonstriatus" RELATED OMO:0003011 [Wikipedia:Smooth_muscle_tissue] synonym: "textus muscularis nonstriatus" EXACT OMO:0003011 [FMA:14070, FMA:TA] synonym: "visceral muscle" NARROW SENSU [] synonym: "visceral muscle tissue" NARROW SENSU [] xref: AAO:0010244 xref: AEO:0000141 xref: BTO:0001260 xref: CALOHA:TS-0943 xref: EFO:0000889 xref: EHDAA2:0003141 xref: EMAPA:32717 xref: EV:0100378 xref: FMA:14070 xref: GAID:167 xref: galen:SmoothMuscle xref: galen:SmoothMuscleTissue xref: MA:0000166 xref: MAT:0000303 xref: MESH:D009130 xref: MIAA:0000303 xref: NCIT:C12437 xref: TAO:0005274 xref: UMLS:C1267092 {source="ncithesaurus:Smooth_Muscle_Tissue"} xref: VHOG:0001246 xref: WBbt:0005781 xref: Wikipedia:Smooth_muscle_tissue xref: XAO:0000175 xref: ZFA:0005274 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: has_part CL:0000192 ! smooth muscle cell disjoint_from: UBERON:0002036 ! striated muscle tissue relationship: composed_primarily_of CL:0000192 ! smooth muscle cell relationship: has_part CL:0000192 ! smooth muscle cell relationship: has_part GO:0071953 ! elastic fiber property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg xsd:anyURI property_value: UBPROP:0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005274", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010244", ontology="AAO", source="AAO:CAM"} property_value: UBPROP:0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001246", ontology="VHOG", source="DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "GO uses visceral and smooth interchangeably. However visceral can also be used in the sense of the viscera. Many fly annotations to smooth muscle terms. If we want to be inclusive of insects have to have a general definition of tissue that includes cells." xsd:string [Term] id: UBERON:0001136 name: mesothelium namespace: uberon def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." [FMA:14074, Wikipedia:Mesothelium] subset: human_subset subset: mouse_subset subset: uberon_slim xref: AEO:0000111 xref: BTO:0002422 xref: CALOHA:TS-1183 xref: EHDAA2_RETIRED:0003111 xref: EHDAA:2331 xref: EHDAA:2349 xref: EHDAA:295 xref: EHDAA:6073 xref: EHDAA:640 xref: EHDAA:646 xref: EMAPA:32856 xref: FMA:14074 xref: MA:0000565 xref: NCIT:C33105 xref: SCTID:361918002 xref: UMLS:C0086610 {source="ncithesaurus:Mesothelium"} xref: Wikipedia:Mesothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000487 ! simple squamous epithelium intersection_of: develops_from UBERON:0000926 ! mesoderm intersection_of: part_of UBERON:0000042 ! serous membrane relationship: composed_primarily_of CL:0000077 {source="FMA"} ! mesothelial cell relationship: part_of UBERON:0000042 ! serous membrane property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg xsd:anyURI [Term] id: UBERON:0001137 name: dorsum namespace: uberon def: "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." [BSPO:0000063, UBERONREF:0000006, Wikipedia:Dorsum_(anatomy)] subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "back" EXACT [FMA:14181] synonym: "back of body proper" EXACT [FMA:14181] synonym: "dorsal part of organism" EXACT [] xref: BTO:0001713 xref: CALOHA:TS-2223 xref: EFO:0001405 xref: FMA:14181 xref: GAID:30 xref: galen:Back xref: MESH:D001415 xref: NCIT:C13062 xref: SCTID:123961009 xref: UMLS:C0004600 {source="ncithesaurus:Back"} xref: Wikipedia:Dorsum_(anatomy) is_a: UBERON:0000475 ! organism subdivision relationship: in_taxon NCBITaxon:33213 ! Bilateria property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG xsd:anyURI property_value: UBPROP:0000007 "dorsal" xsd:string property_value: UBPROP:0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" xsd:string [Term] id: UBERON:0001138 name: superior mesenteric vein namespace: uberon def: "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Superior_mesenteric_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "upper mesenteric vein" RELATED [BTO:0002783] synonym: "vena mesenterica superior" RELATED OMO:0003011 [Wikipedia:Superior_mesenteric_vein] xref: BTO:0002783 xref: EHDAA2:0001951 xref: EHDAA:5414 xref: EMAPA:18643 xref: FMA:14332 xref: MA:0002179 xref: NCIT:C33687 xref: SCTID:278031001 xref: UMLS:C0226742 {source="ncithesaurus:Superior_Mesenteric_Vein"} xref: VHOG:0000552 xref: Wikipedia:Superior_mesenteric_vein is_a: UBERON:0005617 ! mesenteric vein intersection_of: UBERON:0005617 ! mesenteric vein intersection_of: vessel_drains_blood_from UBERON:0002108 ! small intestine relationship: connected_to UBERON:0001639 ! hepatic portal vein relationship: develops_from UBERON:0005487 {source="Wikipedia:Vitelline_vein"} ! vitelline vein relationship: part_of UBERON:0005806 ! portal system relationship: vessel_drains_blood_from UBERON:0002108 ! small intestine property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001143 name: hepatic vein namespace: uberon def: "Vein that carries blood away from the liver[ZFA]." [https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376, Wikipedia:Hepatic_vein, ZFA:0000670] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic veins" RELATED OMO:0003004 [] synonym: "liver vein" EXACT [OBOL:automatic] synonym: "vein of liver" EXACT [OBOL:automatic] synonym: "vena hepatica" EXACT OMO:0003011 [] synonym: "venae hepaticae" RELATED OMO:0003011 [Wikipedia:Hepatic_vein] xref: AAO:0010216 xref: EMAPA:19221 xref: FMA:14337 xref: GAID:534 xref: galen:HepaticVein xref: MA:0003015 xref: MESH:D006503 xref: NCIT:C32736 xref: SCTID:278191001 xref: TAO:0000670 xref: UMLS:C0019155 {source="ncithesaurus:Hepatic_Vein"} xref: Wikipedia:Hepatic_vein xref: XAO:0000387 xref: ZFA:0000670 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0002107 ! liver disjoint_from: UBERON:0001639 ! hepatic portal vein relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0006877 ! vasculature of liver relationship: tributary_of UBERON:0001072 {source="FMA-abduced-lr"} ! inferior vena cava relationship: vessel_drains_blood_from UBERON:0002107 ! liver property_value: editor_note "todo - add developmental relationships for other taxa" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png xsd:anyURI [Term] id: UBERON:0001145 name: ovarian vein namespace: uberon def: "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." [Wikipedia:Ovarian_vein] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "female reproductive system gonad vein" EXACT [OBOL:automatic] synonym: "female reproductive system gonada vein" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system vein" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system vein" EXACT [OBOL:automatic] synonym: "ovary vein" EXACT [OBOL:automatic] synonym: "vein of female reproductive system gonad" EXACT [OBOL:automatic] synonym: "vein of female reproductive system gonada" EXACT [OBOL:automatic] synonym: "vein of gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "vein of gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "vein of ovary" EXACT [OBOL:automatic] synonym: "vena ovarica dextra" RELATED OMO:0003011 [Wikipedia:Ovarian_vein] synonym: "vena ovarica sinistra" RELATED OMO:0003011 [Wikipedia:Ovarian_vein] xref: EMAPA:18644 xref: FMA:14346 xref: MA:0002186 xref: NCIT:C53058 xref: SCTID:278193003 xref: UMLS:C0226720 {source="ncithesaurus:Ovarian_Vein"} xref: Wikipedia:Ovarian_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0000992 ! ovary relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0000992 ! ovary property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg xsd:anyURI [Term] id: UBERON:0001152 name: cystic duct namespace: uberon def: "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." [ISBN:0-683-40008-8, MP:0009493] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ductus cysticus" RELATED OMO:0003011 [Wikipedia:Cystic_duct] xref: EHDAA2:0000333 xref: EHDAA:3045 xref: EMAPA:16841 xref: FMA:14539 xref: GAID:290 xref: galen:CysticDuct xref: MA:0000355 xref: MESH:D003549 xref: NCIT:C32421 xref: SCTID:245398005 xref: TAO:0005166 xref: UMLS:C0010672 {source="ncithesaurus:Cystic_Duct"} xref: VHOG:0000213 xref: Wikipedia:Cystic_duct xref: ZFA:0005166 is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct intersection_of: UBERON:0000058 ! duct intersection_of: continuous_with UBERON:0001174 ! common bile duct intersection_of: continuous_with UBERON:0002110 ! gallbladder disjoint_from: UBERON:0005171 ! hepatic duct relationship: channels_into UBERON:0001174 ! common bile duct relationship: continuous_with UBERON:0001174 ! common bile duct relationship: continuous_with UBERON:0002110 ! gallbladder relationship: develops_from UBERON:0005604 {source="EHDAA2"} ! extrahepatic part of hepatic duct property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI property_value: UBPROP:0000001 "Duct that connects the gall bladder and the common bile duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005166", ontology="TAO", source="ZFIN:Curator"} property_value: UBPROP:0000001 "The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000213", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001155 name: colon namespace: uberon def: "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." [http://orcid.org/0000-0002-2825-0621, http://orcid.org/0000-0002-6601-2165, Wikipedia:Colon_(anatomy), ZFIN:curator] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hindgut" RELATED [] synonym: "large bowel" EXACT [] synonym: "posterior intestine" NARROW [] xref: AAO:0010400 xref: BTO:0000269 xref: CALOHA:TS-0158 xref: EFO:0000361 xref: EMAPA:18939 xref: EV:0100079 xref: FMA:14543 xref: GAID:309 xref: galen:Colon xref: MA:0000335 xref: MAP:0000001 xref: MAT:0000526 xref: MESH:D003106 xref: NCIT:C12382 xref: SCTID:302508007 xref: TAO:0000706 xref: UMLS:C0009368 {source="ncithesaurus:Colon"} xref: VHOG:0000648 xref: Wikipedia:Colon_(anatomy) xref: XAO:0000243 xref: ZFA:0000706 is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000059 {source="FMA"} ! large intestine property_value: editor_note "Some references do not consider the caecum to be part of the colon." xsd:string {xref="http://orcid.org/0000-0002-1572-1316"} property_value: editor_note "TODO - abstract this such that it legitimately covers all vertebrates" xsd:string property_value: UBPROP:0000001 "The last portion of the digestive system, it extracts water and salt from solid wastes before they are eliminated from the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010400", ontology="AAO", source="UBERON:0001155"} property_value: UBPROP:0000001 "The posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates. Wallace et al, 2005.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000706", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000648", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "colonic" xsd:string property_value: UBPROP:0000008 "In mammals, the colon consists of four sections: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon[WP]" xsd:string property_value: UBPROP:0000008 "In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN]" xsd:string property_value: UBPROP:0000009 "it extracts water and salt from solid wastes before they are eliminated from the body[WP]" xsd:string [Term] id: UBERON:0001159 name: sigmoid colon namespace: uberon def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [Wikipedia:Sigmoid_colon] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "colon sigmoideum" RELATED OMO:0003011 [Wikipedia:Sigmoid_colon] synonym: "pelvic colon" RELATED [] synonym: "sigmoid colon" RELATED [] synonym: "sigmoid flexure" RELATED [] xref: BTO:0000645 xref: CALOHA:TS-2044 xref: EFO:0000846 xref: EMAPA:36391 xref: FMA:14548 xref: galen:SigmoidColon xref: MAT:0000314 xref: MESH:D012809 xref: MIAA:0000314 xref: NCIT:C12384 xref: NCIT:C33550 xref: SCTID:362166007 xref: UMLS:C0227391 {source="ncithesaurus:Sigmoid_Colon"} xref: UMLS:C0682612 {source="ncithesaurus:Sigmoid_Flexure"} xref: Wikipedia:Sigmoid_colon is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: continuous_with UBERON:0001052 ! rectum relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001161 name: body of stomach namespace: uberon def: "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." [GO:0014845, Wikipedia:Body_of_stomach] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "corpus gastricum" RELATED OMO:0003011 [BTO:0000505, Wikipedia:Body_of_stomach] synonym: "corpus gastricum (ventriculare)" EXACT [] synonym: "corpus ventriculare" RELATED [BTO:0000505] synonym: "corpus ventriculi" RELATED [BTO:0000505] synonym: "gastric body" EXACT [] synonym: "gastric corpus" RELATED [] synonym: "stomach body" EXACT [] xref: BTO:0000505 xref: EMAPA:35810 xref: FMA:14560 xref: galen:GastricCorpus xref: MA:0002559 xref: NCIT:C12258 xref: SCTID:362140009 xref: UMLS:C0227230 {source="ncithesaurus:Body_of_Stomach"} xref: Wikipedia:Body_of_stomach is_a: UBERON:0009870 {source="FMA"} ! zone of stomach property_value: editor_note "we include this as zone of stomach even though it is not distinguished by gland type" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI [Term] id: UBERON:0001165 name: pyloric antrum namespace: uberon def: "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." [ISBN:0-683-40008-8, MP:0010790] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "antrum" BROAD [] synonym: "antrum of stomach" EXACT [] synonym: "antrum of Willis" RELATED [BTO:0001732] synonym: "antrum pylori" RELATED [BTO:0001732] synonym: "antrum pyloricum" RELATED OMO:0003011 [BTO:0001732, Wikipedia:Pyloric_antrum] synonym: "gastric antrum" RELATED [BTO:0001732] synonym: "stomach antrum" RELATED [] synonym: "stomach pyloric antrum" EXACT [] xref: BTO:0001732 xref: EFO:0002555 xref: EMAPA:17891 xref: FMA:14579 xref: GAID:332 xref: galen:PyloricAntrum xref: MA:0001624 xref: MESH:D011706 xref: NCIT:C12259 xref: SCTID:362142001 xref: UMLS:C0034193 {source="ncithesaurus:Antrum_Pylori"} xref: Wikipedia:Pyloric_antrum is_a: UBERON:0009870 {source="FMA"} ! zone of stomach relationship: continuous_with UBERON:0001161 ! body of stomach relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus relationship: has_part CL:0000502 ! type D enteroendocrine cell relationship: has_part CL:0000508 ! type G enteroendocrine cell relationship: part_of UBERON:0001166 {source="Wikipedia"} ! pylorus property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI [Term] id: UBERON:0001166 name: pylorus namespace: uberon def: "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." [MGI:csmith, MP:0010785] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pars pylorica" EXACT OMO:0003011 [] synonym: "pars pylorica gastricae" EXACT OMO:0003011 [FMA:14581, FMA:TA] synonym: "pyloric part of stomach" EXACT [] synonym: "pyloric region" EXACT [] synonym: "stomach pyloric region" EXACT [EHDAA2:0001580] synonym: "valvula pylori" RELATED OMO:0003011 [Wikipedia:Pylorus] xref: BTO:0001146 xref: EHDAA2:0001580 xref: EHDAA:4860 xref: EMAPA:17631 xref: FMA:14581 xref: GAID:333 xref: galen:Pylorus xref: MA:0002560 xref: MESH:D011708 xref: NCIT:C12260 xref: SCTID:362143006 xref: UMLS:C0034196 {source="ncithesaurus:Pylorus"} xref: VHOG:0000420 xref: Wikipedia:Pylorus is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: has_part UBERON:0001165 ! pyloric antrum intersection_of: has_part UBERON:0008858 ! pyloric canal intersection_of: has_part UBERON:0008861 ! pyloric gastric gland relationship: contributes_to_morphology_of UBERON:0000945 ! stomach relationship: has_part UBERON:0001165 ! pyloric antrum relationship: has_part UBERON:0008858 ! pyloric canal relationship: has_part UBERON:0008861 ! pyloric gastric gland property_value: editor_note "We follow Kardong in defining stomach regions by glands" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI property_value: UBPROP:0000001 "The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000420", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000420", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pyloric" xsd:string [Term] id: UBERON:0001167 name: wall of stomach namespace: uberon def: "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." [MGI:csmith, MP:0010783] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "gastric wall" EXACT [] synonym: "stomach anatomical wall" EXACT [OBOL:automatic] synonym: "stomach wall" EXACT [] synonym: "ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "ventriculus wall" EXACT [OBOL:automatic] synonym: "wall of ventriculus" EXACT [OBOL:automatic] xref: EMAPA:35826 xref: FMA:14582 xref: galen:WallOfStomach xref: MA:0002692 xref: SCTID:279995000 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000945 ! stomach relationship: contributes_to_morphology_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach [Term] id: UBERON:0001168 name: wall of small intestine namespace: uberon def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anatomical wall of small bowel" EXACT [OBOL:automatic] synonym: "anatomical wall of small intestine" EXACT [OBOL:automatic] synonym: "small bowel anatomical wall" EXACT [OBOL:automatic] synonym: "small bowel wall" EXACT [OBOL:automatic] synonym: "small intestinal wall" EXACT [] synonym: "small intestine anatomical wall" EXACT [OBOL:automatic] synonym: "small intestine wall" EXACT [] synonym: "wall of small bowel" EXACT [OBOL:automatic] xref: EMAPA:35785 xref: FMA:14615 xref: MA:0002696 xref: NCIT:C33573 xref: UMLS:C1519375 {source="ncithesaurus:Small_Intestinal_Wall_Tissue"} is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001169 name: wall of large intestine namespace: uberon def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anatomical wall of large intestine" EXACT [OBOL:automatic] synonym: "large intestinal wall" EXACT [] synonym: "large intestine anatomical wall" EXACT [OBOL:automatic] synonym: "large intestine wall" EXACT [] xref: EMAPA:35470 xref: FMA:14619 xref: MA:0002695 is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine [Term] id: UBERON:0001171 name: portal lobule namespace: uberon def: "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [MP:0008992] subset: human_subset subset: mouse_subset subset: pheno_slim xref: FMA:14653 xref: MA:0002498 xref: NCIT:C33341 xref: UMLS:C0682620 {source="ncithesaurus:Portal_Lobule"} is_a: UBERON:0009911 {source="FMA"} ! lobule relationship: contributes_to_morphology_of UBERON:0001280 ! liver parenchyma relationship: part_of UBERON:0001280 {source="MA", source="MP"} ! liver parenchyma [Term] id: UBERON:0001172 name: hepatic acinus namespace: uberon def: "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." [http://orcid.org/0000-0002-6601-2165, http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html] subset: human_subset subset: mouse_subset synonym: "liver acinus" EXACT [] synonym: "portal acinus" EXACT [] xref: EMAPA:35497 xref: FMA:14654 xref: MA:0002496 xref: NCIT:C32992 xref: SCTID:272214009 xref: UMLS:C0227519 {source="ncithesaurus:Liver_Acinus"} is_a: UBERON:0011858 ! acinus of exocrine gland relationship: overlaps UBERON:0001171 ! portal lobule relationship: overlaps UBERON:0004647 ! liver lobule relationship: part_of UBERON:0001280 {source="cjm"} ! liver parenchyma [Term] id: UBERON:0001173 name: biliary tree namespace: uberon def: "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." [DOI:10.1002/ar.20664] comment: The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "biliary tract" RELATED [MA:0001273] xref: AAO:0011020 xref: EMAPA:35172 xref: FMA:14665 xref: MESH:D001659 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: SCTID:181267003 xref: UMLS:C0005423 {source="ncithesaurus:Biliary_Tract"} xref: Wikipedia:Biliary_tract xref: XAO:0000455 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0000062 ! organ intersection_of: composed_primarily_of UBERON:0002394 ! bile duct intersection_of: part_of UBERON:0002294 ! biliary system relationship: composed_primarily_of UBERON:0002394 ! bile duct relationship: contributes_to_morphology_of UBERON:0002423 ! hepatobiliary system relationship: develops_from UBERON:0004912 ! biliary bud relationship: has_part UBERON:0001246 ! interlobular bile duct relationship: has_part UBERON:0001282 ! intralobular bile duct relationship: has_part UBERON:0003703 ! extrahepatic bile duct relationship: part_of UBERON:0002294 ! biliary system property_value: RO:0002171 UBERON:0002110 property_value: UBPROP:0000001 "Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011020", ontology="AAO", source="UBERON:0001173"} [Term] id: UBERON:0001174 name: common bile duct namespace: uberon def: "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." [MGI:csmith, MP:0009495] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ductus choledochus" RELATED OMO:0003011 [Wikipedia:Common_bile_duct] synonym: "ductus choledochus (biliaris)" EXACT [] xref: EHDAA2:0000303 xref: EHDAA:3981 xref: EMAPA:17201 xref: FMA:14667 xref: GAID:282 xref: galen:CommonBileDuct xref: MA:0001631 xref: MESH:D003135 xref: NCIT:C12698 xref: SCTID:362199009 xref: TAO:0005165 xref: UMLS:C0009437 {source="ncithesaurus:Common_Bile_Duct"} xref: VHOG:0000214 xref: Wikipedia:Common_bile_duct xref: ZFA:0005165 is_a: UBERON:0003703 ! extrahepatic bile duct relationship: channels_into UBERON:0001064 ! ventral pancreatic duct relationship: continuous_with UBERON:0001152 ! cystic duct relationship: continuous_with UBERON:0001175 ! common hepatic duct property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005165", ontology="TAO", source="ZFIN:Curator"} property_value: UBPROP:0000001 "The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000214", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001175 name: common hepatic duct namespace: uberon def: "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." [Wikipedia:Common_hepatic_duct, ZFIN:curator] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "ductus hepaticus communis" RELATED OMO:0003011 [Wikipedia:Common_hepatic_duct] synonym: "hepatic duct" RELATED [] xref: EMAPA:19101 xref: FMA:14668 xref: GAID:286 xref: MA:0002660 xref: MESH:D006500 xref: NCIT:C32356 xref: SCTID:245403006 xref: UMLS:C0019149 {source="ncithesaurus:Common_Hepatic_Duct"} xref: VHOG:0000220 xref: Wikipedia:Common_hepatic_duct is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct relationship: channels_into UBERON:0001174 ! common bile duct relationship: continuous_with UBERON:0001176 {source="Wikipedia"} ! right hepatic duct relationship: continuous_with UBERON:0001177 {source="Wikipedia"} ! left hepatic duct relationship: develops_from UBERON:0001007 ! digestive system relationship: develops_from UBERON:0001173 ! biliary tree relationship: develops_from UBERON:0002294 ! biliary system relationship: develops_from UBERON:0002423 ! hepatobiliary system relationship: develops_from UBERON:0010081 ! future common hepatic duct relationship: immediate_transformation_of UBERON:0010081 {evidence="definitional"} ! future common hepatic duct relationship: part_of UBERON:0005604 {source="MA"} ! extrahepatic part of hepatic duct property_value: editor_note "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg xsd:anyURI property_value: UBPROP:0000001 "The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000220", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001176 name: right hepatic duct namespace: uberon def: "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26034] subset: human_subset subset: mouse_subset synonym: "ductus hepaticus dexter" RELATED OMO:0003011 [] xref: EHDAA2:0001727 xref: EHDAA:3992 xref: EMAPA:32797 xref: FMA:14669 xref: MA:0001639 xref: NCIT:C33476 xref: SCTID:245401008 xref: UMLS:C0227557 {source="ncithesaurus:Right_Hepatic_Duct"} xref: VHOG:0000217 is_a: UBERON:0003703 ! extrahepatic bile duct intersection_of: UBERON:0003703 ! extrahepatic bile duct intersection_of: continuous_with UBERON:0001114 ! right lobe of liver relationship: continuous_with UBERON:0001114 ! right lobe of liver relationship: part_of UBERON:0005171 ! hepatic duct property_value: UBPROP:0000001 "The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000217", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001177 name: left hepatic duct namespace: uberon def: "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26035] subset: human_subset subset: mouse_subset synonym: "ductus hepaticus sinister" RELATED OMO:0003011 [] xref: EHDAA2:0000941 xref: EHDAA:3990 xref: EMAPA:32795 xref: FMA:14670 xref: MA:0001638 xref: NCIT:C32960 xref: SCTID:245400009 xref: UMLS:C0227560 {source="ncithesaurus:Left_Hepatic_Duct"} xref: VHOG:0000218 is_a: UBERON:0003703 ! extrahepatic bile duct intersection_of: UBERON:0003703 ! extrahepatic bile duct intersection_of: continuous_with UBERON:0001115 ! left lobe of liver relationship: continuous_with UBERON:0001115 ! left lobe of liver relationship: part_of UBERON:0005171 ! hepatic duct property_value: UBPROP:0000001 "The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000218", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001178 name: visceral peritoneum namespace: uberon def: "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "visceral serous membrane of peritoneum" EXACT [UBERON:cjm] xref: EMAPA:16592 xref: FMA:14703 xref: SCTID:362702003 xref: TAO:0005132 xref: VHOG:0001528 xref: Wikipedia:Visceral_peritoneum xref: ZFA:0005132 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0002358 ! peritoneum property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png xsd:anyURI [Term] id: UBERON:0001179 name: peritoneal cavity namespace: uberon def: "Anatomical cavity bounded by visceral and parietal peritoneum." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/86, Wikipedia:Peritoneal_cavity] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cavitas peritonealis" RELATED OMO:0003011 [BTO:0001782, Wikipedia:Peritoneal_cavity] synonym: "saccus serosus peritonei" RELATED OMO:0003011 [Wikipedia:Peritoneal_cavity] xref: BTO:0001782 xref: EHDAA2:0001446 xref: EMAPA:16138 xref: FMA:14704 xref: GAID:24 xref: MA:0000054 xref: MESH:D010529 xref: NCIT:C12769 xref: SCTID:181616008 xref: UMLS:C1704247 {source="ncithesaurus:Peritoneal_Cavity"} xref: VHOG:0000852 xref: Wikipedia:Peritoneal_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: adjacent_to UBERON:0001178 ! visceral peritoneum intersection_of: adjacent_to UBERON:0001366 ! parietal peritoneum intersection_of: luminal_space_of UBERON:0035820 ! peritoneal sac relationship: adjacent_to UBERON:0001178 ! visceral peritoneum relationship: adjacent_to UBERON:0001366 ! parietal peritoneum relationship: develops_from UBERON:0003887 {source="Wikipedia"} ! intraembryonic coelom relationship: luminal_space_of UBERON:0035820 ! peritoneal sac relationship: part_of UBERON:0035820 ! peritoneal sac property_value: UBPROP:0000001 "The potential space between the parietal and visceral layers of the peritoneum, which are normally in contact. The peritoneal cavity is divided into the greater and lesser sac. The greater sac is the peritoneal cavity, and the lesser sac is the omental bursa. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000852", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/peritoneal+cavity"} property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000852", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001190 name: ovarian artery namespace: uberon def: "An artery that supplies an ovary." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria ovarica" RELATED OMO:0003011 [Wikipedia:Ovarian_artery] synonym: "ovarian arterial tree" EXACT [] xref: EMAPA:18620 xref: FMA:14761 xref: MA:0002012 xref: NCIT:C33242 xref: SCTID:244280002 xref: UMLS:C0226411 {source="ncithesaurus:Ovarian_Artery"} xref: Wikipedia:Ovarian_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0000992 ! ovary relationship: connected_to UBERON:0001516 ! abdominal aorta relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0000992 ! ovary property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]." xsd:string {source="Wikipedia:Ovarian_artery"} [Term] id: UBERON:0001193 name: hepatic artery namespace: uberon def: "An artery that supplies the liver." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Hepatic_artery_proper] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "arteria hepatica" RELATED [BTO:0004307] synonym: "arteria hepatica propria" EXACT OMO:0003011 [] xref: BTO:0004307 xref: EMAPA:17859 xref: FMA:14769 xref: GAID:496 xref: galen:HepaticArtery xref: MA:0001963 xref: MESH:D006499 xref: NCIT:C32729 xref: SCTID:76015000 xref: TAO:0005161 xref: UMLS:C0019145 {source="ncithesaurus:Hepatic_Artery"} xref: ZFA:0005161 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0002107 ! liver relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002107 ! liver property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png xsd:anyURI property_value: IAO:0000232 "currently defined in a generic fashion." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery that supplies blood to the liver.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005161", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001194 name: splenic artery namespace: uberon def: "An artery that supplies the spleen." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria lienalis" RELATED OMO:0003011 [Wikipedia:Splenic_artery] synonym: "arteria splenica" EXACT OMO:0003011 [Wikipedia:Splenic_artery] synonym: "lienal artery" EXACT [MA:0001991] xref: EMAPA:19216 xref: FMA:14773 xref: GAID:510 xref: galen:SplenicArtery xref: MA:0001991 xref: MA:0003177 xref: MESH:D013157 xref: NCIT:C33597 xref: SCTID:244266009 xref: UMLS:C0037996 {source="ncithesaurus:Splenic_Artery"} xref: Wikipedia:Splenic_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0002106 ! spleen disjoint_from: UBERON:0001640 ! celiac artery relationship: connecting_branch_of UBERON:0001640 ! celiac artery relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002106 ! spleen property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/268 xsd:anyURI [Term] id: UBERON:0001199 name: mucosa of stomach namespace: uberon def: "The mucosal layer that lines the stomach." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "gastric mucosa" EXACT [] synonym: "gastric mucous membrane" EXACT [] synonym: "Magenschleimhaut" RELATED [BTO:0001308] synonym: "mucosa of organ of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of ventriculus" EXACT [OBOL:automatic] synonym: "mucosa of ventriculus" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach" EXACT [] synonym: "mucous membrane of ventriculus" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of ventriculus" EXACT [OBOL:automatic] synonym: "stomach mucosa" EXACT [] synonym: "stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach mucous membrane" EXACT [OBOL:automatic] synonym: "stomach organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (gaster)" EXACT [] synonym: "tunica mucosa gastricae" EXACT OMO:0003011 [FMA:14907, FMA:TA] synonym: "tunica mucosa gastris" RELATED OMO:0003011 [BTO:0001308, Wikipedia:Gastric_mucosa] synonym: "ventriculus mucosa" EXACT [OBOL:automatic] synonym: "ventriculus mucosa of organ" EXACT [OBOL:automatic] synonym: "ventriculus mucous membrane" EXACT [OBOL:automatic] synonym: "ventriculus organ mucosa" EXACT [OBOL:automatic] xref: BTO:0001308 xref: CALOHA:TS-0404 xref: EMAPA:35817 xref: FMA:14907 xref: GAID:321 xref: galen:GastricMucosa xref: MA:0002683 xref: MESH:D005753 xref: NCIT:C32656 xref: SCTID:362131005 xref: UMLS:C0017136 {source="ncithesaurus:Gastric_Mucosa"} xref: Wikipedia:Gastric_mucosa is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000945 ! stomach relationship: capable_of GO:0001696 ! gastric acid secretion relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg xsd:anyURI property_value: UBPROP:0000001 "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]." xsd:string {source="Wikipedia:Gastric_mucosa"} [Term] id: UBERON:0001200 name: submucosa of stomach namespace: uberon def: "The fibrous connective tissue layer beneath the stomach mucosa." [MGI:csmith, MP:0010794] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "gastric submucosa" EXACT [] synonym: "stomach submucosa" EXACT [] synonym: "submucosa of ventriculus" EXACT [OBOL:automatic] synonym: "submucous layer of stomach" RELATED [BTO:0002110] synonym: "tela submucosa (gaster)" EXACT [] synonym: "tela submucosa gastricae" EXACT OMO:0003011 [FMA:14908, FMA:TA] synonym: "tela submucosa ventriculi" RELATED [BTO:0002110] synonym: "ventriculus submucosa" EXACT [OBOL:automatic] xref: BTO:0002110 xref: EMAPA:35825 xref: FMA:14908 xref: MA:0002685 xref: NCIT:C32663 xref: SCTID:52459002 xref: UMLS:C0227211 {source="ncithesaurus:Gastric_Submucosa"} is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000945 ! stomach relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001201 name: serosa of stomach namespace: uberon def: "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." [MGI:csmith, MP:0010793] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "anatomical wall of stomach serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of stomach serous membrane" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus serous membrane" EXACT [OBOL:automatic] synonym: "gastric serosa" RELATED [] synonym: "gastric wall serosa" EXACT [OBOL:automatic] synonym: "gastric wall serous membrane" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "serosa of gastric wall" EXACT [OBOL:automatic] synonym: "serosa of stomach anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of stomach wall" EXACT [OBOL:automatic] synonym: "serosa of ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of ventriculus wall" EXACT [OBOL:automatic] synonym: "serosa of wall of stomach" EXACT [OBOL:automatic] synonym: "serosa of wall of ventriculus" EXACT [OBOL:automatic] synonym: "serous coat of stomach" EXACT [] synonym: "serous membrane of anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "serous membrane of gastric wall" EXACT [OBOL:automatic] synonym: "serous membrane of stomach anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of stomach wall" EXACT [OBOL:automatic] synonym: "serous membrane of ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of ventriculus wall" EXACT [OBOL:automatic] synonym: "serous membrane of wall of stomach" EXACT [OBOL:automatic] synonym: "serous membrane of wall of ventriculus" EXACT [OBOL:automatic] synonym: "stomach anatomical wall serosa" EXACT [OBOL:automatic] synonym: "stomach anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "stomach serosa" EXACT [] synonym: "stomach wall serosa" EXACT [OBOL:automatic] synonym: "stomach wall serous membrane" EXACT [OBOL:automatic] synonym: "tunica serosa (gaster)" EXACT [] synonym: "tunica serosa gastricae" EXACT OMO:0003011 [FMA:14914, FMA:TA] synonym: "ventriculus anatomical wall serosa" EXACT [OBOL:automatic] synonym: "ventriculus anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "ventriculus wall serosa" EXACT [OBOL:automatic] synonym: "ventriculus wall serous membrane" EXACT [OBOL:automatic] synonym: "visceral peritoneum of stomach" EXACT [] synonym: "wall of stomach serosa" EXACT [OBOL:automatic] synonym: "wall of stomach serous membrane" EXACT [OBOL:automatic] synonym: "wall of ventriculus serosa" EXACT [OBOL:automatic] synonym: "wall of ventriculus serous membrane" EXACT [OBOL:automatic] xref: EMAPA:35822 xref: FMA:14914 xref: MA:0001626 xref: NCIT:C32662 xref: SCTID:1353004 xref: UMLS:C1517453 {source="ncithesaurus:Gastric_Serosal_Surface"} is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001167 ! wall of stomach relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach property_value: editor_note "TODO - check serosa/peritoneum" xsd:string [Term] id: UBERON:0001202 name: pyloric sphincter namespace: uberon def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pyloric valve" EXACT [Wikipedia:Pylorus] xref: AAO:0011093 xref: EMAPA:19251 xref: FMA:14916 xref: MA:0002952 xref: NCIT:C33433 xref: SCTID:268073008 xref: UMLS:C0227238 {source="ncithesaurus:Pyloric_Sphincter"} xref: VHOG:0001466 xref: XAO:0000457 is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001166 ! pylorus relationship: adjacent_to UBERON:0002114 ! duodenum relationship: continuous_with UBERON:0008858 ! pyloric canal relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus property_value: RO:0002161 NCBITaxon:8355 property_value: UBPROP:0000003 "(...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001466", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00076.x", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001204 name: mucosa of small intestine namespace: uberon def: "A mucosa that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mucosa of organ of small bowel" EXACT [OBOL:automatic] synonym: "mucosa of organ of small intestine" EXACT [OBOL:automatic] synonym: "mucosa of small bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of small bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of small intestine" EXACT [] synonym: "organ mucosa of small bowel" EXACT [OBOL:automatic] synonym: "organ mucosa of small intestine" EXACT [OBOL:automatic] synonym: "small bowel mucosa" EXACT [OBOL:automatic] synonym: "small bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "small bowel mucous membrane" EXACT [OBOL:automatic] synonym: "small bowel organ mucosa" EXACT [OBOL:automatic] synonym: "small intestinal mucosa" EXACT [] synonym: "small intestine mucosa" EXACT [] synonym: "small intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "small intestine mucous membrane" EXACT [] synonym: "small intestine organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (intestinum tenue)" EXACT [] synonym: "tunica mucosa intestini tenuis" EXACT OMO:0003011 [FMA:14933, FMA:TA] xref: BTO:0001259 xref: CALOHA:TS-0941 xref: EMAPA:35780 xref: FMA:14933 xref: MA:0002686 xref: NCIT:C33568 xref: SCTID:362144000 xref: UMLS:C0227261 {source="ncithesaurus:Small_Intestinal_Mucosa"} is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001205 name: submucosa of small intestine namespace: uberon def: "Submucosal tissue in the small intestines." [Wikipedia:Small_intestinal_submucosa] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "small bowel submucosa" EXACT [OBOL:automatic] synonym: "small intestinal submucosa" EXACT [] synonym: "small intestine submucosa" EXACT [] synonym: "submucosa of small bowel" EXACT [OBOL:automatic] synonym: "tela submucosa (intestinum tenue)" EXACT [] synonym: "tela submucosa intestini tenuis" EXACT OMO:0003011 [BTO:0002112] xref: BTO:0002112 xref: EMAPA:37564 {source="MA:th"} xref: FMA:14934 xref: MA:0001562 xref: NCIT:C33572 xref: SCTID:691000 xref: UMLS:C0227268 {source="ncithesaurus:Small_Intestinal_Submucosa"} xref: Wikipedia:Small_intestinal_submucosa is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine [Term] id: UBERON:0001206 name: serosa of small intestine namespace: uberon def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "serosa of small bowel" EXACT [OBOL:automatic] synonym: "serous coat of small intestine" EXACT [] synonym: "serous membrane of small bowel" EXACT [OBOL:automatic] synonym: "serous membrane of small intestine" EXACT [OBOL:automatic] synonym: "small bowel serosa" EXACT [OBOL:automatic] synonym: "small bowel serous membrane" EXACT [OBOL:automatic] synonym: "small intestinal serosa" EXACT [] synonym: "small intestine serosa" EXACT [] synonym: "small intestine serous membrane" EXACT [OBOL:automatic] synonym: "tunica serosa (intestinum tenue)" EXACT [] synonym: "tunica serosa intestini tenuis" EXACT OMO:0003011 [FMA:14938, FMA:TA] synonym: "visceral peritoneum of small intestine" EXACT [] xref: EMAPA:37561 {source="MA:th"} xref: FMA:14938 xref: MA:0001558 xref: SCTID:8266009 is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine relationship: part_of UBERON:0001243 ! serosa of intestine property_value: UBPROP:0000010 "duodenum, 1st part serosa, 2nd - 4th adventitia" xsd:string [Term] id: UBERON:0001207 name: mucosa of large intestine namespace: uberon def: "A mucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "large intestinal mucosa" EXACT [] synonym: "large intestine mucosa" EXACT [] synonym: "large intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "large intestine mucous membrane" EXACT [OBOL:automatic] synonym: "large intestine organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of large intestine" EXACT [OBOL:automatic] synonym: "mucous membrane of large intestine" EXACT [] synonym: "organ mucosa of large intestine" EXACT [OBOL:automatic] synonym: "tunica mucosa intestini crassi" EXACT OMO:0003011 [FMA:14969, FMA:TA] xref: CALOHA:TS-2106 xref: EMAPA:35467 xref: FMA:14969 xref: MA:0002688 xref: NCIT:C32926 xref: UMLS:C0734203 {source="ncithesaurus:Large_Intestinal_Mucosa"} is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine relationship: part_of UBERON:0001242 ! intestinal mucosa [Term] id: UBERON:0001208 name: submucosa of large intestine namespace: uberon def: "A submucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "large intestinal submucosa" EXACT [] synonym: "large intestine submucosa" EXACT [] synonym: "submucous layer of large intestine" RELATED [BTO:0002111] synonym: "tela submucosa intestini crassi" EXACT OMO:0003011 [FMA:14970, FMA:TA] xref: BTO:0002111 xref: EMAPA:37560 {source="MA:th"} xref: FMA:14970 xref: MA:0002690 xref: NCIT:C32930 xref: UMLS:C0734204 {source="ncithesaurus:Large_Intestinal_Submucosa"} is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine [Term] id: UBERON:0001209 name: serosa of large intestine namespace: uberon def: "A serous membrane that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "large intestinal serosa" EXACT [] synonym: "large intestine serosa" EXACT [] synonym: "large intestine serous membrane" EXACT [OBOL:automatic] synonym: "serous coat of large intestine" EXACT [] synonym: "serous membrane of large intestine" EXACT [OBOL:automatic] synonym: "tunica serosa intestini crassi" EXACT OMO:0003011 [FMA:14975, FMA:TA] synonym: "visceral peritoneum of large intestine" EXACT [] xref: EMAPA:37557 {source="MA:th"} xref: FMA:14975 xref: MA:0001546 xref: NCIT:C32929 xref: UMLS:C1517727 {source="ncithesaurus:Large_Intestinal_Serosal_Surface"} is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 ! wall of large intestine relationship: part_of UBERON:0001243 ! serosa of intestine property_value: editor_note "TODO - check serosa/peritoneum" xsd:string [Term] id: UBERON:0001212 name: duodenal gland namespace: uberon def: "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." [Wikipedia:Brunner's_glands] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "Brunner's gland" EXACT [FMA:15060] synonym: "gland of Brunner" EXACT [FMA:15060] synonym: "glandula duodenales" RELATED OMO:0003011 [BTO:0002376] synonym: "glandula duodenales Brunneri" RELATED OMO:0003011 [BTO:0002376] synonym: "submucosal gland of duodenum" EXACT [] xref: BTO:0002376 xref: EMAPA:36522 xref: FMA:15060 xref: GAID:314 xref: MA:0001551 xref: MESH:D002011 xref: NCIT:C13010 xref: SCTID:41298001 xref: UMLS:C0006323 {source="ncithesaurus:Brunner_s_Gland"} xref: Wikipedia:Brunner's_glands is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0011148 {notes="compound tubular"} ! submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: part_of UBERON:0002114 ! duodenum relationship: in_taxon NCBITaxon:40674 {notes="unclear for Aves", source="ISBN:9780521617147"} ! Mammalia relationship: located_in UBERON:0003332 {source="FMA, modified"} ! submucosa of duodenum relationship: part_of UBERON:0002114 ! duodenum property_value: editor_note "currently defined as equivalent to any submucosal gland in the duodenum." xsd:string property_value: UBPROP:0000008 "Said to be absent outside mammlian (Andrew 1959) but Ziswiler and Farner (1972) noted similar glands at the gastroduodenal junction of some birds" xsd:string {source="ISBN:9780521617147"} [Term] id: UBERON:0001213 name: intestinal villus namespace: uberon alt_id: UBERON:0007607 def: "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." [MGI:csmith, MGI:rbabiuk, MP:0008108] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "enteric villi" EXACT OMO:0003004 [HP:0011473] synonym: "enteric villous" EXACT [HP:0011473] synonym: "enteric villus" EXACT [HP:0011473] synonym: "intestinal villi" EXACT OMO:0003004 [ZFA:0005125] synonym: "intestinal villus layer" RELATED [] synonym: "small intestine villus" RELATED [MA:0001563] synonym: "villi intestinales" EXACT OMO:0003004 [] synonym: "villi intestinales" RELATED OMO:0003011 [Wikipedia:Intestinal_villus] synonym: "villus" EXACT [BTO:0003121] synonym: "villus intestinalis (intestinum tenue)" EXACT [FMA:15072] xref: BTO:0003121 xref: EMAPA:35784 xref: FMA:15072 xref: MA:0001563 xref: NCIT:C33874 xref: SCTID:23230007 xref: TAO:0005125 xref: UMLS:C1519988 {source="ncithesaurus:Villus"} xref: Wikipedia:Intestinal_villus xref: ZFA:0005125 is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: has_part CL:0000066 ! epithelial cell relationship: has_part UBERON:0001981 ! blood vessel relationship: has_part UBERON:0012425 ! striated border microvillus layer relationship: part_of UBERON:0001204 {gci_relation="part_of", gci_filler="NCBITaxon:9606", notes="may be present in other parts in other species", source="FMA"} ! mucosa of small intestine relationship: part_of UBERON:0001277 {source="ZFA"} ! intestinal epithelium property_value: editor_note "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg xsd:anyURI property_value: UBPROP:0000001 "The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005125", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000012 "the BTO class refers to a generic villous" xsd:string {external_ontology="BTO"} [Term] id: UBERON:0001215 name: inferior mesenteric vein namespace: uberon def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "lower mesenteric vein" RELATED [BTO:0002782] synonym: "vena mesenterica inferior" RELATED OMO:0003011 [Wikipedia:Inferior_mesenteric_vein] xref: BTO:0002782 xref: EHDAA2:0000819 xref: EHDAA:8712 xref: EMAPA:18642 xref: FMA:15391 xref: MA:0002178 xref: NCIT:C32782 xref: SCTID:281055007 xref: UMLS:C0226754 {source="ncithesaurus:Inferior_Mesenteric_Vein"} xref: VHOG:0001118 xref: Wikipedia:Inferior_mesenteric_vein is_a: UBERON:0005617 ! mesenteric vein intersection_of: UBERON:0005617 ! mesenteric vein intersection_of: vessel_drains_blood_from UBERON:0000059 ! large intestine relationship: tributary_of UBERON:0003713 {source="FMA/obol"} ! splenic vein relationship: vessel_drains_blood_from UBERON:0000059 ! large intestine property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001238 name: lamina propria of small intestine namespace: uberon def: "Lamina propria that is part_of the small intestine." [GOC:Obol] subset: human_subset subset: mouse_subset synonym: "lamina propria mucosa of small bowel" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of small intestine" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of small bowel" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of small intestine" EXACT [] synonym: "lamina propria of mucosa of small intestine" EXACT [] synonym: "lamina propria of small bowel" EXACT [OBOL:automatic] synonym: "small bowel lamina propria" EXACT [OBOL:automatic] synonym: "small bowel lamina propria mucosa" EXACT [OBOL:automatic] synonym: "small bowel lamina propria mucosae" EXACT [OBOL:automatic] synonym: "small intestine lamina propria" EXACT [] synonym: "small intestine lamina propria mucosa" EXACT [OBOL:automatic] synonym: "small intestine lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:35779 xref: FMA:15651 xref: MA:0001554 xref: NCIT:C49297 xref: SCTID:63588008 xref: UMLS:C1711325 {source="ncithesaurus:Small_Intestinal_Lamina_Propria"} is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001204 ! mucosa of small intestine [Term] id: UBERON:0001241 name: crypt of Lieberkuhn of small intestine namespace: uberon def: "The tubular intestinal glands found in the mucosal membranes of the small intestine." [ISBN:0-683-40008-8, MP:0004841] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "crypt of Lieberkuhn of small bowel" EXACT [OBOL:automatic] synonym: "crypt of Lieberkuhn of small intestine" EXACT [OBOL:automatic] synonym: "intestinal gland of small bowel" EXACT [OBOL:automatic] synonym: "intestinal gland of small intestine" EXACT [OBOL:automatic] synonym: "Lieberkühn crypt of small bowel" EXACT [OBOL:automatic] synonym: "Lieberkühn crypt of small intestine" EXACT [OBOL:automatic] synonym: "small bowel crypt of Lieberkuhn" EXACT [OBOL:automatic] synonym: "small bowel intestinal gland" EXACT [OBOL:automatic] synonym: "small bowel Lieberkühn crypt" EXACT [OBOL:automatic] synonym: "small intestinal crypt of Lieberkuhn" EXACT [] synonym: "small intestine crypt of Lieberkuhn" EXACT [OBOL:automatic] synonym: "small intestine intestinal gland" EXACT [OBOL:automatic] synonym: "small intestine Lieberkühn crypt" EXACT [OBOL:automatic] xref: EMAPA:35777 xref: FMA:15693 xref: MA:0001552 xref: NCIT:C33565 xref: SCTID:52688008 xref: UMLS:C0227267 {source="ncithesaurus:Small_Intestinal_Crypt_of_Lieberkuhn"} is_a: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: part_of UBERON:0002108 ! small intestine relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: UBERON:0001242 name: intestinal mucosa namespace: uberon def: "Mucosal layer that lines the intestine." [UBERON:cjm] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "bowel mucosa" EXACT [OBOL:automatic] synonym: "bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "bowel mucous membrane" EXACT [OBOL:automatic] synonym: "bowel organ mucosa" EXACT [OBOL:automatic] synonym: "intestine mucosa" EXACT [] synonym: "intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "intestine mucous membrane" EXACT [OBOL:automatic] synonym: "intestine organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bowel" EXACT [OBOL:automatic] synonym: "mucosa of intestine" EXACT [] synonym: "mucosa of organ of bowel" EXACT [OBOL:automatic] synonym: "mucosa of organ of intestine" EXACT [OBOL:automatic] synonym: "mucous membrane of bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of intestine" EXACT [OBOL:automatic] synonym: "organ mucosa of bowel" EXACT [OBOL:automatic] synonym: "organ mucosa of intestine" EXACT [OBOL:automatic] synonym: "tunica mucosa intestini" EXACT [] xref: BTO:0000642 xref: EMAPA:35440 xref: FMA:15695 xref: GAID:296 xref: MA:0001537 xref: MESH:D007413 xref: NCIT:C49241 xref: SCTID:362080002 xref: UMLS:C0021839 {source="ncithesaurus:Intestinal_Mucosa"} is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine [Term] id: UBERON:0001243 name: serosa of intestine namespace: uberon def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anatomical wall of bowel serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of bowel serous membrane" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine serous membrane" EXACT [OBOL:automatic] synonym: "bowel anatomical wall serosa" EXACT [OBOL:automatic] synonym: "bowel anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "bowel wall serosa" EXACT [OBOL:automatic] synonym: "bowel wall serous membrane" EXACT [OBOL:automatic] synonym: "intestinal serosa" EXACT [] synonym: "intestinal wall serosa" EXACT [OBOL:automatic] synonym: "intestinal wall serous membrane" EXACT [OBOL:automatic] synonym: "intestine anatomical wall serosa" EXACT [OBOL:automatic] synonym: "intestine anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "intestine serosa" EXACT [] synonym: "intestine wall serosa" EXACT [OBOL:automatic] synonym: "intestine wall serous membrane" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "serosa of bowel anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of bowel wall" EXACT [OBOL:automatic] synonym: "serosa of intestinal wall" EXACT [OBOL:automatic] synonym: "serosa of intestine anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of intestine wall" EXACT [OBOL:automatic] synonym: "serosa of wall of bowel" EXACT [OBOL:automatic] synonym: "serosa of wall of intestine" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "serous membrane of bowel anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of bowel wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestinal wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestine anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestine wall" EXACT [OBOL:automatic] synonym: "serous membrane of wall of bowel" EXACT [OBOL:automatic] synonym: "serous membrane of wall of intestine" EXACT [OBOL:automatic] synonym: "visceral peritoneum of intestine" EXACT [] synonym: "wall of bowel serosa" EXACT [OBOL:automatic] synonym: "wall of bowel serous membrane" EXACT [OBOL:automatic] synonym: "wall of intestine serosa" EXACT [OBOL:automatic] synonym: "wall of intestine serous membrane" EXACT [OBOL:automatic] xref: EMAPA:37619 {source="MA:th"} xref: FMA:15701 xref: MA:0001538 is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001262 ! wall of intestine property_value: editor_note "TODO - check serosa/peritoneum" xsd:string [Term] id: UBERON:0001245 name: anus namespace: uberon def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [Wikipedia:Anus, ZFIN:curator] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "anal opening" EXACT [] synonym: "anal orifice" EXACT [] synonym: "opening of terminal part of digestive tract" EXACT [] synonym: "proctodeum" RELATED [] xref: BTO:0001680 xref: CALOHA:TS-2005 xref: EV:0100082 xref: FBbt:00047153 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:15711 xref: GAID:312 xref: galen:Anus xref: MA:0000331 xref: NCIT:C43362 xref: SCTID:181262009 xref: TADS:0000066 xref: TGMA:0001279 xref: UMLS:C0003461 {source="ncithesaurus:Anus"} xref: WBbt:0005364 xref: Wikipedia:Anus is_a: UBERON:0000161 ! orifice is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000161 ! orifice intersection_of: distalmost_part_of UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0000931 ! proctodeum relationship: distalmost_part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "anal" xsd:string property_value: UBPROP:0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" xsd:string [Term] id: UBERON:0001246 name: interlobular bile duct namespace: uberon def: "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." [MP:0009500] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "interlobular ductule" EXACT [MP:0009500] xref: FMA:15767 xref: MA:0002668 xref: NCIT:C32827 xref: SCTID:83488001 xref: UMLS:C0227515 {source="ncithesaurus:Interlobular_Bile_Duct"} xref: Wikipedia:Interlobular_bile_ducts is_a: UBERON:0003704 {source="FMA", source="MA-part-of"} ! intrahepatic bile duct relationship: connects UBERON:0004058 ! biliary ductule relationship: connects UBERON:0014719 ! intralobular duct relationship: contributes_to_morphology_of UBERON:0001279 ! portal triad relationship: part_of UBERON:0001279 {source="FMA", source="MA", source="MP"} ! portal triad [Term] id: UBERON:0001262 name: wall of intestine namespace: uberon def: "An anatomical wall that is part of a intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "bowel anatomical wall" EXACT [OBOL:automatic] synonym: "bowel wall" EXACT [OBOL:automatic] synonym: "bowel wall" RELATED [MA:0001525] synonym: "intestinal wall" EXACT [] synonym: "intestine anatomical wall" EXACT [OBOL:automatic] synonym: "intestine wall" EXACT [] synonym: "wall of bowel" EXACT [OBOL:automatic] xref: BTO:0000647 xref: EMAPA:35444 xref: FMA:15949 xref: MA:0001525 xref: MA:0002693 xref: NCIT:C49478 xref: UMLS:C1708548 {source="ncithesaurus:Intestinal_Wall_Tissue"} is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine property_value: editor_note "we place two MA classes here due to the official ncit2ma mapping to intestinal wall tissue; not clear how bowel and intestine are different" xsd:string [Term] id: UBERON:0001263 name: pancreatic acinus namespace: uberon def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [MP:0009145] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "acinus pancreaticus" EXACT OMO:0003011 [FMA:16011] synonym: "pancreas acinus" EXACT [] synonym: "pancreatic acinar" RELATED [] synonym: "pancreatic acini" RELATED OMO:0003004 [] xref: BTO:0000028 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EMAPA:35651 xref: FMA:16011 xref: MA:0002417 xref: NCIT:C49268 xref: SCTID:247604006 xref: UMLS:C0227578 {source="ncithesaurus:Pancreatic_Acinus"} is_a: UBERON:0013232 ! serous acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: composed_primarily_of CL:0002064 ! pancreatic acinar cell relationship: contributes_to_morphology_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0007324 {source="FMA"} ! pancreatic lobule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001264 name: pancreas namespace: uberon def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." [GO:0031016] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0010112 xref: BTO:0000988 xref: CALOHA:TS-0736 xref: EFO:0000855 xref: EHDAA2:0001367 xref: EHDAA:6893 xref: EMAPA:17503 xref: EV:0100092 xref: FMA:7198 xref: GAID:334 xref: galen:Pancreas xref: MA:0000120 xref: MAT:0000075 xref: MESH:D010179 xref: MIAA:0000075 xref: NCIT:C12393 xref: SCTID:181277001 xref: TAO:0000140 xref: UMLS:C0030274 {source="ncithesaurus:Pancreas"} xref: VHOG:0000050 xref: Wikipedia:Pancreas xref: XAO:0000136 xref: ZFA:0000140 is_a: UBERON:0002075 ! viscus relationship: has_developmental_contribution_from UBERON:0003923 {source="Wikipedia"} ! dorsal pancreatic bud relationship: has_developmental_contribution_from UBERON:0003924 {source="Wikipedia"} ! ventral pancreatic bud relationship: has_part UBERON:0000016 ! endocrine pancreas relationship: has_part UBERON:0000017 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! exocrine pancreas relationship: in_taxon NCBITaxon:7742 {source="PMID:16417468"} ! Vertebrata property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/pancreas-female/v1.3/assets/3d-vh-f-pancreas.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/pancreas-male/v1.3/assets/3d-vh-m-pancreas.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010112", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000050", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pancreatic" xsd:string property_value: UBPROP:0000008 "As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)" xsd:string {source="PMID:20959416"} property_value: UBPROP:0000008 "The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm" xsd:string property_value: UBPROP:0000009 "The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans" xsd:string {source="PMID:16417468"} [Term] id: UBERON:0001265 name: trabecula of spleen namespace: uberon def: "A trabecula that is part of a spleen." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "spleen trabeculum" EXACT [] synonym: "splenic trabecula" EXACT [] synonym: "trabeculae of spleen" EXACT OMO:0003004 [] xref: EMAPA:35808 xref: FMA:16027 xref: MA:0000758 xref: NCIT:C33607 xref: SCTID:61987002 xref: UMLS:C0229688 {source="ncithesaurus:Splenic_Trabecula"} xref: Wikipedia:Trabeculae_of_spleen is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:1000024 {source="FMA"} ! parenchyma of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001268 name: peritoneal fluid namespace: uberon def: "Transudate contained in the peritoneal cavity." [FMA:16515] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim xref: BTO:0001031 xref: EMAPA:35683 xref: FMA:16515 xref: MA:0002531 xref: MESH:D001202 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: ncithesaurus:Peritoneal_Fluid xref: Wikipedia:Peritoneal_fluid is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0007779 ! transudate intersection_of: located_in UBERON:0001179 ! peritoneal cavity relationship: located_in UBERON:0001179 ! peritoneal cavity [Term] id: UBERON:0001276 name: epithelium of stomach namespace: uberon def: "The epithelial layer of the stomach ." [MP:0000471] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "epithelial tissue of stomach" EXACT [OBOL:automatic] synonym: "epithelial tissue of ventriculus" EXACT [OBOL:automatic] synonym: "epithelium of ventriculus" EXACT [OBOL:automatic] synonym: "gastric epithelium" RELATED [BTO:0000500] synonym: "stomach epithelial tissue" EXACT [OBOL:automatic] synonym: "stomach epithelium" EXACT [OBOL:automatic] synonym: "ventriculus epithelial tissue" EXACT [OBOL:automatic] synonym: "ventriculus epithelium" EXACT [OBOL:automatic] xref: BTO:0000500 xref: CALOHA:TS-2068 xref: EHDAA2:0001918 xref: EMAPA:17023 xref: FMA:17091 xref: MA:0001610 xref: SCTID:64977002 xref: VHOG:0001433 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004808 ! gastrointestinal system epithelium is_a: UBERON:0015833 ! foregut epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000945 ! stomach relationship: contributes_to_morphology_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach property_value: UBPROP:0000012 "in FMA this is classified as simple columnar, MA divides this into squamous and glandular" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001277 name: intestinal epithelium namespace: uberon def: "Epithelial layer that lines the intestine." [UBERON:cjm] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "bowel epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of bowel" EXACT [OBOL:automatic] synonym: "epithelial tissue of intestine" EXACT [OBOL:automatic] synonym: "epithelium of bowel" EXACT [OBOL:automatic] synonym: "epithelium of intestine" EXACT [OBOL:automatic] synonym: "intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "intestine epithelium" RELATED [] synonym: "villous epithelium" NARROW [ZFA:0005124] xref: BTO:0000781 xref: EMAPA:32873 xref: FMA:17229 xref: MA:0001536 xref: NCIT:C49240 xref: SCTID:266135004 xref: TAO:0005124 xref: UMLS:C0226890 {source="ncithesaurus:Intestinal_Epithelium"} xref: Wikipedia:Intestinal_epithelium xref: ZFA:0005124 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004808 ! gastrointestinal system epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000160 ! intestine relationship: contributes_to_morphology_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001242 ! intestinal mucosa property_value: UBPROP:0000001 "Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005124", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001278 name: epithelium of large intestine namespace: uberon def: "An epithelium that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of large intestine" EXACT [OBOL:automatic] synonym: "large intestinal epithelium" EXACT [] synonym: "large intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "large intestine epithelium" EXACT [] xref: CALOHA:TS-2105 xref: EMAPA:35466 xref: FMA:17301 xref: MA:0001545 is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001207 ! mucosa of large intestine [Term] id: UBERON:0001279 name: portal triad namespace: uberon def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:csmith, MP:0008993] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "trias hepatica" EXACT [] synonym: "trias hepatica" RELATED OMO:0003011 [Wikipedia:Portal_triad] xref: FMA:17523 xref: MA:0002499 xref: NCIT:C33342 xref: SCTID:362192000 xref: UMLS:C0227514 {source="ncithesaurus:Portal_Triad"} xref: Wikipedia:Portal_triad is_a: UBERON:0034921 ! multi organ part structure relationship: contributes_to_morphology_of UBERON:0001171 ! portal lobule relationship: has_part UBERON:0001193 ! hepatic artery relationship: has_part UBERON:0002017 ! portal vein relationship: has_part UBERON:0003704 ! intrahepatic bile duct relationship: part_of UBERON:0001172 ! hepatic acinus property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000013 "The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver." xsd:string [Term] id: UBERON:0001280 name: liver parenchyma namespace: uberon alt_id: UBERON:0003223 def: "The functional units of the liver including the lobules." [MP:0008986] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "hepatic parenchyma" EXACT [FMA:17540] synonym: "hepatic parenchyme" RELATED [VHOG:0000539] synonym: "liver parenchyme" EXACT [XAO:0000454] synonym: "parenchyma of liver" EXACT [FMA:17540] xref: AAO:0010405 xref: EHDAA2:0001004 xref: EHDAA:2201 xref: EMAPA:17203 xref: FMA:17540 xref: MA:0000366 xref: NCIT:C32735 xref: SCTID:363535004 xref: UMLS:C0736268 xref: VHOG:0000539 xref: XAO:0000454 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002107 ! liver relationship: contributes_to_morphology_of UBERON:0002107 ! liver relationship: develops_from UBERON:0008835 {source="XAO"} ! hepatic diverticulum relationship: part_of UBERON:0002107 ! liver property_value: UBPROP:0000003 "the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000539", ontology="VHOG", source="DOI:10.1002/ar.20524 Hardman RC, Volz DC, Kullman SW, Hinton DE, An in vivo look at vertebrate liver architecture: three-dimensional reconstruction from Medaka (Oryzias latipes). The Anatomical Record (2007)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001281 name: hepatic sinusoid namespace: uberon alt_id: UBERON:0003275 def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [Wikipedia:Hepatic_sinusoid, ZFIN:curator] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic sinusoids" RELATED [] synonym: "liver hepatic sinusoids" EXACT [EHDAA2:0000999] synonym: "liver sinusoid" EXACT [] synonym: "liver sinusoidal blood vessel" EXACT [OBOL:automatic] synonym: "sinusoid of liver" EXACT [OBOL:automatic] synonym: "sinusoidal blood vessel of liver" EXACT [OBOL:automatic] synonym: "vas capillare sinusoideum" EXACT [] synonym: "vas sinusoideum" EXACT OMO:0003011 [Wikipedia:Hepatic_sinusoid] xref: EHDAA2:0000999 xref: EMAPA:17365 xref: FMA:17543 xref: MA:0000367 xref: NCIT:C32733 xref: SCTID:67435004 xref: TAO:0005091 xref: UMLS:C0227523 {source="ncithesaurus:Hepatic_Sinusoid"} xref: VHOG:0000708 xref: Wikipedia:Hepatic_sinusoid xref: ZFA:0005091 is_a: UBERON:0003909 ! sinusoid is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0003909 ! sinusoid intersection_of: part_of UBERON:0002107 ! liver relationship: connected_to UBERON:0006841 ! central vein of liver relationship: contributes_to_morphology_of UBERON:0004647 ! liver lobule relationship: develops_in UBERON:0001113 ! lobe of liver relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0004647 ! liver lobule relationship: part_of UBERON:0006877 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! vasculature of liver property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000708", ontology="VHOG", source="DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001282 name: intralobular bile duct namespace: uberon def: "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." [MGI:csmith, MP:0009499] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "canal of Hering" RELATED [] synonym: "canal of Herring" EXACT [FMA:17545] synonym: "canals of Hering" RELATED OMO:0003004 [Wikipedia:Canals_of_Hering] synonym: "cholangiole" EXACT [FMA:17545] synonym: "duct of Herring" RELATED [Wikipedia:Canals_of_Hering] synonym: "ductus interlobularis bilifer" EXACT OMO:0003011 [FMA:17545, FMA:TA] synonym: "intrahepatic bile ductule" RELATED [Wikipedia:Canals_of_Hering] xref: FMA:17545 xref: MA:0002669 xref: NCIT:C32255 xref: SCTID:227002 xref: SCTID:269922006 xref: UMLS:C0227517 {source="ncithesaurus:Canal_of_Hering"} xref: Wikipedia:Canals_of_Hering is_a: UBERON:0003704 {source="FMA"} ! intrahepatic bile duct is_a: UBERON:0014716 ! interlobular duct relationship: contributes_to_morphology_of UBERON:0004647 ! liver lobule relationship: has_part CL:0000182 ! hepatocyte relationship: has_part CL:1000488 ! cholangiocyte relationship: part_of UBERON:0001172 {source="FMA"} ! hepatic acinus relationship: part_of UBERON:0004647 {source="FMA"} ! liver lobule property_value: editor_note "Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct)" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001353 name: anal region namespace: uberon def: "The anus and surrounding regions. Encompasses both internal and external regions, where present." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "posterior" RELATED [] synonym: "posterior end of organism" RELATED [] xref: EFO:0000847 xref: EHDAA2:0000122 xref: EHDAA:2931 xref: EMAPA:16831 xref: MA:0000329 xref: MAT:0000042 xref: MIAA:0000042 xref: NCIT:C32069 xref: SCTID:362680001 xref: UMLS:C0230120 {source="ncithesaurus:Anal_Region"} xref: VHOG:0000395 xref: WBbt:0006919 is_a: UBERON:0000475 ! organism subdivision relationship: has_developmental_contribution_from UBERON:0000931 {evidence="cjm"} ! proctodeum relationship: overlaps UBERON:0006866 ! terminal part of digestive tract property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/507 xsd:anyURI property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000395", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001366 name: parietal peritoneum namespace: uberon alt_id: UBERON:0004459 def: "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "parietal serous membrane of peritoneum" EXACT [UBERON:cjm] synonym: "peritoneal cavity lining" RELATED [] xref: AAO:0010816 xref: EMAPA:16591 xref: FMA:21451 xref: SCTID:362700006 xref: TAO:0005131 xref: VHOG:0001527 xref: Wikipedia:Parietal_peritoneum xref: ZFA:0005131 is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: part_of UBERON:0002358 ! peritoneum relationship: attaches_to UBERON:0003697 ! abdominal wall relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0002358 ! peritoneum property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png xsd:anyURI property_value: UBPROP:0000001 "Peritoneum attached to the abdominal wall.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010816", ontology="AAO", source="AAO:JMG"} [Term] id: UBERON:0001416 name: skin of abdomen namespace: uberon def: "A zone of skin that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "abdomen skin" EXACT [] synonym: "abdomen zone of skin" EXACT [OBOL:automatic] synonym: "abdominal skin" EXACT [] synonym: "skin of abdomen proper" EXACT [FMA:22988] synonym: "zone of skin of abdomen" EXACT [OBOL:automatic] xref: EFO:0000214 xref: FMA:22988 xref: FMA:23000 xref: MA:0000523 xref: NCIT:C52758 xref: SCTID:361707007 xref: UMLS:C0222166 {source="ncithesaurus:Abdominal_Skin"} is_a: UBERON:0003836 ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0001417 name: skin of neck namespace: uberon def: "A zone of skin that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "neck (volume) zone of skin" EXACT [OBOL:automatic] synonym: "neck skin" EXACT [] synonym: "neck zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of neck" EXACT [OBOL:automatic] synonym: "zone of skin of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37277 {source="MA:th"} xref: FMA:23021 xref: FMA:23022 xref: MA:0000590 xref: NCIT:C52756 xref: SCTID:361705004 xref: UMLS:C0205030 {source="ncithesaurus:Neck_Skin"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0001418 name: skin of thorax namespace: uberon def: "A zone of skin that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "thoracic skin" EXACT [] synonym: "thorax skin" EXACT [] synonym: "thorax zone of skin" EXACT [OBOL:automatic] synonym: "upper body skin" RELATED [] synonym: "zone of skin of thorax" EXACT [OBOL:automatic] xref: EMAPA:37765 {source="MA:th"} xref: FMA:23028 xref: FMA:23029 xref: MA:0000564 xref: SCTID:281723000 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0001421 name: pectoral girdle region namespace: uberon def: "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [FMA:23217, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cingulum membri superioris" EXACT OMO:0003011 [FMA:23217, FMA:TA] synonym: "cingulum membri superioris" NARROW [FMA:TA] synonym: "girdle - pectoral" EXACT [] synonym: "pectoral girdle" RELATED [] synonym: "pectoral region" RELATED [] synonym: "shoulder girdle" NARROW [FMA:23217] synonym: "upper limb girdle" NARROW [FMA:23217] xref: EMAPA:37856 {source="MA:th"} xref: FMA:23217 xref: galen:ShoulderGirdle xref: SCTID:229759004 xref: VSAO:0000305 is_a: UBERON:0007823 ! appendage girdle region is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007823 ! appendage girdle region intersection_of: part_of UBERON:0010708 ! pectoral complex disjoint_from: UBERON:0007831 ! pectoral girdle skeleton relationship: has_skeleton UBERON:0007831 ! pectoral girdle skeleton relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism relationship: part_of UBERON:0010708 ! pectoral complex property_value: IAO:0000232 "this class describes the organism subdivision, NOT the skeleton within. See also: skeleton of pectoral girdle (UBERON:0007831)." xsd:string property_value: RO:0002171 UBERON:0001271 property_value: UBPROP:0000001 "An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000305", ontology="VSAO", source="https://orcid.org/0000-0002-6601-2165"} property_value: UBPROP:0000005 "Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO]" xsd:string {date_retrieved="2012-09-06", external_class="VSAO:0000305", ontology="VSAO", source="Curator"} [Term] id: UBERON:0001434 name: skeletal system namespace: uberon def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000027] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "set of all bones and joints" NARROW SENSU [] synonym: "skeleton system" EXACT [] synonym: "Skelettsystem" RELATED [BTO:0001486] xref: AAO:0000566 xref: BTO:0001486 xref: CALOHA:TS-1320 xref: EFO:0000806 xref: EHDAA2:0003168 xref: EMAPA:35773 xref: FMA:23881 xref: MA:0000018 xref: NCIT:C12788 xref: TAO:0000434 xref: UMLS:C0037253 {source="ncithesaurus:Skeletal_System"} xref: VHOG:0001254 xref: VSAO:0000027 xref: XAO:0003060 xref: ZFA:0000434 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: has_part UBERON:0004288 ! skeleton intersection_of: has_part UBERON:0004770 ! articular system disjoint_from: UBERON:0001474 ! bone element disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0004288 ! skeleton relationship: has_part UBERON:0004770 ! articular system relationship: part_of UBERON:0002204 ! musculoskeletal system property_value: RO:0002171 UBERON:0001016 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/The-skeletal-system xsd:anyURI property_value: UBPROP:0000001 "Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000434", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000001 "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000027", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} property_value: UBPROP:0000001 "System that provides physical support to the organism.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000566", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001254", ontology="VHOG", source="DOI:10.1159/000324245 Donoghue PCJ, Sansom IJ, Origin and early evolution of vertebrate skeletonization. Microscopy research and technique (2002)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "skeletal" xsd:string property_value: UBPROP:0000012 "GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates" xsd:string {external_ontology="GO"} [Term] id: UBERON:0001444 name: subdivision of head namespace: uberon subset: human_subset subset: mouse_subset subset: non_informative synonym: "head region" RELATED [] synonym: "head subdivision" EXACT [] synonym: "region of head" RELATED [] xref: FMA:24218 xref: SCTID:123852005 xref: XAO:0000040 is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0001456 name: face namespace: uberon def: "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "facia/facies" RELATED OMO:0003011 [Wikipedia:Face] synonym: "visage" RELATED [BTO:0003369] xref: BTO:0003369 xref: CALOHA:TS-2216 xref: EMAPA:32763 xref: FMA:24728 xref: GAID:64 xref: galen:Face xref: HAO:0000316 xref: MA:0002473 xref: MESH:D005145 xref: NCIT:C13071 xref: SCTID:302549007 xref: UMLS:C0015450 {source="ncithesaurus:Face"} xref: Wikipedia:Face is_a: UBERON:0001444 ! subdivision of head relationship: contributes_to_morphology_of UBERON:0000033 ! head relationship: has_part UBERON:0000018 {gci_filler="NCBITaxon:50557", gci_relation="part_of"} ! compound eye relationship: has_part UBERON:0011156 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! facial skeleton relationship: has_skeleton UBERON:0011156 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! facial skeleton property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg xsd:anyURI property_value: UBPROP:0000001 "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face." xsd:string {source="FMA:24728"} property_value: UBPROP:0000001 "The area that extends from the median ocellus to the oral foramen[HAO]." xsd:string {source="HAO:0000316", source="http://api.hymao.org/api/ref/67791", taxon="NCBITaxon:7399"} property_value: UBPROP:0000007 "facial" xsd:string property_value: UBPROP:0000011 "The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence)" xsd:string {source="vanat.cvm.umn.edu/TFFlectPDFs/LectFaceDevelop.pdf"} [Term] id: UBERON:0001458 name: skin of lip namespace: uberon def: "A zone of skin that is part of a lip [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "lip skin" EXACT [] synonym: "lip zone of skin" EXACT [OBOL:automatic] synonym: "skin of lips" RELATED OMO:0003004 [] synonym: "zone of skin of lip" EXACT [OBOL:automatic] xref: EMAPA:37643 {source="MA:th"} xref: FMA:24764 xref: MA:0001579 xref: NCIT:C12291 xref: SCTID:244092005 xref: UMLS:C0222101 {source="ncithesaurus:Skin_of_the_Lip"} is_a: UBERON:1000021 ! skin of face intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0001833 ! lip relationship: part_of UBERON:0001833 ! lip [Term] id: UBERON:0001474 name: bone element namespace: uberon def: "Skeletal element that is composed of bone tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/277, PSPUB:0000170, VSAO:0000057] subset: efo_slim subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bone" RELATED [AEO:0000082, BTO:0000140, MA:0001459, VHOG:0001190] synonym: "bone organ" EXACT [FMA:5018] synonym: "bones" RELATED OMO:0003004 [ZFA:0001514] xref: AAO:0000047 xref: AEO:0000082 xref: BTO:0000140 xref: CALOHA:TS-0088 xref: EFO:0000298 xref: EHDAA2:0003082 xref: EMAPA:32782 xref: ENVO:00002039 xref: EV:0100140 xref: FMA:30317 xref: FMA:5018 xref: GAID:92 xref: galen:Bone xref: MA:0001459 xref: MAT:0000299 xref: MIAA:0000299 xref: NCIT:C12366 xref: SCTID:90780006 xref: TAO:0001514 xref: UMLS:C0262950 {source="ncithesaurus:Bone"} xref: VHOG:0001190 xref: VSAO:0000057 xref: Wikipedia:Bone xref: XAO:0000169 xref: ZFA:0001514 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue disjoint_from: UBERON:0001630 ! muscle organ disjoint_from: UBERON:0005090 ! muscle structure relationship: composed_primarily_of UBERON:0002481 {source="VSAO-modified"} ! bone tissue relationship: in_taxon NCBITaxon:7742 ! Vertebrata property_value: RO:0002171 UBERON:0001015 property_value: RO:0002171 UBERON:0001630 property_value: RO:0002171 UBERON:0002385 property_value: UBPROP:0000001 "Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000047", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001514", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Skeletal element that is composed of bone tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000057", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000047", ontology="AAO"} property_value: UBPROP:0000003 "The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001190", ontology="VHOG", source="DOI:10.1159/000324245 Murdock DJ, Donoghue PC, Evolutionary Origins of Animal Skeletal Biomineralization. Cells Tissues Organs (2011)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001484 name: articular capsule namespace: uberon def: "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." [Wikipedia:Articular_capsule] subset: human_subset subset: mouse_subset subset: organ_slim subset: uberon_slim synonym: "capsula articularis" EXACT OMO:0003011 [FMA:34836, FMA:TA] synonym: "capsulae articulares" RELATED OMO:0003011 [Wikipedia:Articular_capsule] synonym: "fibrous capsule of joint" EXACT [] synonym: "joint capsule" EXACT [] synonym: "joint fibrous capsule" EXACT [] xref: EMAPA:37621 {source="MA:th"} xref: FMA:34836 xref: GAID:263 xref: galen:JointCapsule xref: MA:0001519 xref: MESH:D017746 xref: NCIT:C32259 xref: NCIT:C84388 xref: SCTID:182238002 xref: UMLS:C0206207 {source="ncithesaurus:Joint_Capsule"} xref: Wikipedia:Articular_capsule is_a: UBERON:0000094 ! membrane organ intersection_of: UBERON:0000094 ! membrane organ intersection_of: has_part UBERON:0007616 ! layer of synovial tissue intersection_of: surrounds UBERON:0002217 ! synovial joint relationship: has_part UBERON:0007616 ! layer of synovial tissue relationship: surrounds UBERON:0002217 ! synovial joint property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png xsd:anyURI property_value: UBPROP:0000012 "check ncita" xsd:string {external_ontology="ncit"} [Term] id: UBERON:0001496 name: ascending aorta namespace: uberon def: "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." [GO:0035905, Wikipedia:Ascending_aorta] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "aorta ascendens" RELATED OMO:0003011 [Wikipedia:Ascending_aorta] synonym: "ascending thoracic aorta" EXACT [EMAPA:17014] synonym: "pars ascendens aortae" EXACT [] synonym: "pars ascendens aortae" RELATED OMO:0003011 [Wikipedia:Ascending_aorta] xref: EHDAA2:0000147 xref: EHDAA:9828 xref: EMAPA:17014 xref: FMA:3736 xref: MA:0002570 xref: NCIT:C32150 xref: SCTID:181299009 xref: UMLS:C0003956 {source="ncithesaurus:Ascending_Aorta"} xref: Wikipedia:Ascending_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: develops_from UBERON:0005338 {source="EHDAA2"} ! outflow tract aortic component relationship: has_developmental_contribution_from UBERON:0002061 ! truncus arteriosus relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac relationship: part_of UBERON:0001515 ! thoracic aorta property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001508 name: arch of aorta namespace: uberon def: "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." [ISBN:0-683-40008-8, MP:0004113] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "aortic arch" RELATED [FMA:3768] synonym: "arcus aortae" EXACT OMO:0003011 [FMA:3768, FMA:TA] synonym: "thoracic aorta" RELATED [GAID:471] xref: BTO:0000157 xref: EFO:0002526 xref: EHDAA2:0000132 xref: EMAPA:17613 xref: FMA:3768 xref: GAID:471 xref: MA:0000475 xref: SCTID:181300001 xref: VHOG:0001196 xref: Wikipedia:Arch_of_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: connected_to UBERON:0001496 ! ascending aorta relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: develops_from UBERON:0003121 {notes="left arch 4 in human", source="embryology.ch"} ! pharyngeal arch artery 4 relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta relationship: part_of UBERON:0001515 ! thoracic aorta property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: IAO:0000232 "Do not confuse with aortic arch" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001196", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/arch+of+aorta"} property_value: UBPROP:0000003 "The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001196", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460 and p.461 Figure 12.20", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "birds have right aortic arch, mammals left." xsd:string [Term] id: UBERON:0001514 name: descending aorta namespace: uberon def: "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." [GO:0035906, Wikipedia:Descending_aorta] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "aorta descendens" RELATED OMO:0003011 [Wikipedia:Descending_aorta] synonym: "pars descendens aortae" EXACT [FMA:3784] synonym: "pars descendens aortae" RELATED OMO:0003011 [Wikipedia:Descending_aorta] xref: EMAPA:18606 xref: FMA:3784 xref: MA:0002571 xref: NCIT:C32455 xref: SCTID:261399002 xref: UMLS:C0011666 {source="ncithesaurus:Descending_Aorta"} xref: Wikipedia:Descending_aorta is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005800 {source="FMA"} ! section of aorta relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0005805 {source="Wikipedia"} ! dorsal aorta relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta relationship: has_developmental_contribution_from UBERON:0005622 ! right dorsal aorta property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "results from fusion of left and right dorsal aortae" xsd:string [Term] id: UBERON:0001515 name: thoracic aorta namespace: uberon def: "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [http://www.medterms.com, MP:0010468] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "aorta thoracalis" RELATED OMO:0003011 [Wikipedia:Thoracic_aorta] synonym: "aorta thoracica" EXACT OMO:0003011 [FMA:3786, FMA:TA] synonym: "pars thoracica aortae" RELATED OMO:0003011 [Wikipedia:Thoracic_aorta] synonym: "thoracic part of aorta" EXACT [] xref: BTO:0000157 xref: EFO:0002525 xref: EMAPA:18603 xref: FMA:3786 xref: GAID:471 xref: galen:ThoracicAorta xref: MA:0002569 xref: MESH:D001013 xref: NCIT:C33766 xref: SCTID:302510009 xref: UMLS:C1522460 {source="ncithesaurus:Thoracic_Aorta"} xref: Wikipedia:Thoracic_aorta is_a: UBERON:0005800 {source="FMA"} ! section of aorta intersection_of: UBERON:0005800 ! section of aorta intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: contributes_to_morphology_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000915 ! thoracic segment of trunk property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png xsd:anyURI [Term] id: UBERON:0001516 name: abdominal aorta namespace: uberon def: "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." [BTO:0002976, Wikipedia:Abdominal_aorta] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "abdominal part of aorta" EXACT [FMA:3789] synonym: "abdominal part of aorta" RELATED [BTO:0002976] synonym: "aorta abdominalis" RELATED OMO:0003011 [BTO:0002976, Wikipedia:Abdominal_aorta] synonym: "descending abdominal aorta" EXACT [FMA:3789] synonym: "pars abdominalis aortae" EXACT [FMA:3789] synonym: "pars abdominalis aortae" RELATED OMO:0003011 [BTO:0002976, Wikipedia:Abdominal_aorta] xref: BTO:0002976 xref: EFO:0002524 xref: EMAPA:17856 xref: FMA:3789 xref: GAID:470 xref: galen:AbdominalAorta xref: MA:0000474 xref: MESH:D001012 xref: NCIT:C32038 xref: SCTID:244231007 xref: UMLS:C0003484 {source="ncithesaurus:Abdominal_Aorta"} xref: Wikipedia:Abdominal_aorta is_a: UBERON:0005800 ! section of aorta relationship: connected_to UBERON:0002345 ! descending thoracic aorta relationship: contributes_to_morphology_of UBERON:0001514 ! descending aorta relationship: overlaps UBERON:0000916 ! abdomen relationship: part_of UBERON:0001514 {source="FMA"} ! descending aorta property_value: editor_note "Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001529 name: brachiocephalic artery namespace: uberon def: "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." [MGI:csmith, MP:0010663] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "brachiocephalic trunk" EXACT [MA:0001922] synonym: "innominate" BROAD [Wikipedia:Brachiocephalic_artery] synonym: "innominate artery" EXACT [Wikipedia:Brachiocephalic_artery] synonym: "truncus brachiocephalicus" EXACT OMO:0003011 [FMA:3932, FMA:TA] synonym: "truncus brachiocephalicus" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_artery] xref: EFO:0002550 xref: EHDAA2:0000835 xref: EMAPA:17615 xref: FMA:3932 xref: GAID:476 xref: galen:BrachioCephalicArtery xref: MA:0001922 xref: MESH:D016122 xref: NCIT:C32814 xref: SCTID:244244002 xref: UMLS:C0006094 {source="ncithesaurus:Innominate_Artery"} xref: Wikipedia:Brachiocephalic_artery is_a: UBERON:0004573 ! systemic artery relationship: channels_from UBERON:0001508 ! arch of aorta relationship: connected_to UBERON:0001508 ! arch of aorta relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0007204 ! brachiocephalic vasculature property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001530 name: common carotid artery plus branches namespace: uberon def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [Wikipedia:Common_carotid_artery] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "a. carotis communis" RELATED OMO:0003011 [Wikipedia:Common_carotid_artery] synonym: "carotid artery" BROAD [FMA:3939] synonym: "carotid artery system" EXACT [EHDAA2:0000217] synonym: "common carotid artery" EXACT INCONSISTENT [FMA:3939] synonym: "trunk of common carotid tree" EXACT [FMA:3939] xref: CALOHA:TS-0116 xref: EHDAA2:0000217 xref: EHDAA:7331 xref: EMAPA:17855 xref: FMA:3939 xref: GAID:479 xref: MA:0001926 xref: MESH:D017536 xref: NCIT:C32352 xref: SCTID:362041005 xref: UMLS:C0162859 {source="ncithesaurus:Common_Carotid_Artery"} xref: VHOG:0000272 xref: Wikipedia:Common_carotid_artery is_a: UBERON:0004573 {source="FMA"} ! systemic artery relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0004363 {source="Wikipedia"} ! pharyngeal arch artery relationship: existence_starts_during UBERON:0000068 ! embryo stage relationship: part_of RO:0002577 ! system property_value: editor_note "we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery'" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: IAO:0000232 "This class represents the adult and developing structures'" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae" xsd:string [Term] id: UBERON:0001533 name: subclavian artery namespace: uberon def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: unverified_taxonomic_grouping subset: vertebrate_core synonym: "arteria subclavia" EXACT OMO:0003011 [XAO:0000365] synonym: "arteria subclavia" RELATED OMO:0003011 [Wikipedia:Subclavian_artery] synonym: "arterial tree of upper limb" EXACT [] synonym: "PA" RELATED OMO:0003000 [] synonym: "pectoral artery" EXACT [] synonym: "subclavian arterial tree" EXACT [] xref: AAO:0010232 xref: EHDAA2:0001933 xref: EHDAA:4357 xref: EMAPA:17617 xref: FMA:3951 xref: GAID:511 xref: MA:0002045 xref: MESH:D013348 xref: NCIT:C33643 xref: SCTID:265790007 xref: TAO:0005086 xref: UMLS:C0038530 {source="ncithesaurus:Subclavian_Artery"} xref: Wikipedia:Subclavian_artery xref: XAO:0000365 xref: ZFA:0005086 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004573 ! systemic artery relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0002457 {source="EHDAA2"} ! intersomitic artery relationship: develops_from UBERON:0005622 {source="EHDAA2"} ! right dorsal aorta relationship: overlaps UBERON:0000915 ! thoracic segment of trunk relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0004710 ! pectoral appendage property_value: editor_note "Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO)" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010232", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP]" xsd:string {source="Wikipedia:Subclavian_artery"} property_value: UBPROP:0000001 "The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005086", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001534 name: right subclavian artery namespace: uberon def: "The subclavian artery that supplies the right pectoral appendage." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia dextra" EXACT OMO:0003011 [FMA:3953, FMA:TA] xref: EHDAA2:0004514 xref: EMAPA:37384 {source="MA:th"} xref: FMA:3953 xref: MA:0002047 xref: NCIT:C33490 xref: SCTID:244246000 xref: UMLS:C0226261 {source="ncithesaurus:Right_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism relationship: branching_part_of UBERON:0001529 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! brachiocephalic artery relationship: connected_to UBERON:0001529 ! brachiocephalic artery relationship: develops_from UBERON:0003121 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="right arch 4 in human", source="embryology.ch"} ! pharyngeal arch artery 4 relationship: in_right_side_of UBERON:0000468 ! multicellular organism property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery" xsd:string property_value: UBPROP:0000011 "proximal part arises from right 4th aortic arch in humans" xsd:string [Term] id: UBERON:0001555 name: digestive tract namespace: uberon def: "A tube extending from the mouth to the anus." [https://github.com/geneontology/go-ontology/issues/7549, Wikipedia:Talk\:Human_gastrointestinal_tract] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "alimentary canal" NARROW [] synonym: "alimentary tract" NARROW [] synonym: "digestive canal" RELATED [BTO:0000058] synonym: "digestive tube" EXACT [] synonym: "enteric tract" EXACT [ZFA:0000112] synonym: "gut" BROAD [] synonym: "gut tube" RELATED [] xref: AAO:0010023 xref: BILA:0000083 xref: BTO:0000511 xref: BTO:0000545 xref: EHDAA2:0000726 xref: EHDAA:518 xref: EMAPA:16247 xref: FBbt:00003125 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45615 xref: galen:AlimentaryTract xref: MA:0000917 xref: MESH:D041981 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C34082 xref: TAO:0000112 xref: TGMA:0001819 xref: UMLS:C0017189 {source="ncithesaurus:Gastrointestinal_Tract"} xref: VHOG:0000309 xref: WBbt:0005743 xref: ZFA:0000112 is_a: UBERON:0000025 ! tube relationship: connects UBERON:0000165 ! mouth relationship: develops_from UBERON:0000922 ! embryo relationship: develops_from UBERON:0007026 ! presumptive gut relationship: immediate_transformation_of UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0001007 ! digestive system property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002161 NCBITaxon:41324 {source="DOI:10.1371/journal.pone.0016309"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The alimentary or digestive tract, and associated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000112", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000309", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA also has a term 'gastrointestinal tract', but this includes the liver." xsd:string {external_ontology="FMA"} property_value: UBPROP:0000012 "we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509" xsd:string {external_ontology="MA"} property_value: UBPROP:0000013 "we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this" xsd:string [Term] id: UBERON:0001558 name: lower respiratory tract namespace: uberon def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lower_respiratory_tract] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "lower respiratory system" EXACT [] xref: EHDAA2:0001036 xref: EMAPA:16738 xref: FMA:45662 xref: MA:0000435 xref: SCTID:281488008 xref: VHOG:0000382 xref: Wikipedia:Lower_respiratory_tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: has_part UBERON:0000170 ! pair of lungs property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001584 name: left subclavian artery namespace: uberon def: "The subclavian artery that supplies the left pectoral appendage." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia (sinistra)" EXACT OMO:0003011 [FMA:4694, FMA:TA] xref: EMAPA:37100 {source="MA:th"} xref: FMA:4694 xref: MA:0002046 xref: NCIT:C32972 xref: SCTID:244245001 xref: UMLS:C0226262 {source="ncithesaurus:Left_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism relationship: channels_from UBERON:0001508 ! arch of aorta relationship: in_left_side_of UBERON:0000468 ! multicellular organism property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in humans, branches off the arch of aorta" xsd:string property_value: UBPROP:0000011 "arises from left intersegmental 6th artery in the region of the 6th -7th cervical segment in humans" xsd:string [Term] id: UBERON:0001585 name: anterior vena cava namespace: uberon def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Superior_vena_cava] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cranial vena cava" RELATED [VHOG:0001195] synonym: "precava" RELATED [] synonym: "superior caval vein" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "superior vena cava" EXACT [FMA:4720] synonym: "vena cava superior" RELATED OMO:0003011 [BTO:0002683, Wikipedia:Superior_vena_cava] synonym: "vena maxima" RELATED OMO:0003011 [Wikipedia:Superior_vena_cava] xref: BTO:0002683 xref: EHDAA2:0001962 xref: EHDAA:8726 xref: EMAPA:18417 xref: FMA:4720 xref: GAID:549 xref: galen:SuperiorVenaCava xref: MA:0000481 xref: MESH:D014683 xref: NCIT:C12816 xref: SCTID:181368006 xref: UMLS:C0042459 {source="ncithesaurus:Superior_Vena_Cava"} xref: VHOG:0001195 xref: Wikipedia:Superior_vena_cava is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: vessel_drains_blood_from UBERON:0000153 ! anterior region of body relationship: connected_to UBERON:0002078 ! right cardiac atrium relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0000153 ! anterior region of body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001195", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green)." xsd:string [Term] id: UBERON:0001586 name: internal jugular vein namespace: uberon def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [Wikipedia:Internal_jugular_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "internal jugular" EXACT [EHDAA2:0000877] synonym: "internal jugular venous tree" EXACT [] synonym: "vena jugularis interna" RELATED OMO:0003011 [Wikipedia:Internal_jugular_vein] xref: AAO:0010236 xref: EHDAA2:0000877 xref: EHDAA:5407 xref: EMAPA:17620 xref: FMA:4724 xref: galen:InternalJugularVein xref: MA:0002157 xref: NCIT:C32849 xref: RETIRED_EHDAA2:0000878 xref: SCTID:181372005 xref: UMLS:C0226550 {source="ncithesaurus:Internal_Jugular_Vein"} xref: Wikipedia:Internal_jugular_vein xref: XAO:0000382 is_a: UBERON:0004711 ! jugular vein relationship: connected_to UBERON:0003711 ! brachiocephalic vein relationship: vessel_drains_blood_from UBERON:0000955 ! brain relationship: vessel_drains_blood_from UBERON:0001456 ! face property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010236", ontology="AAO", source="AAO:BJB"} [Term] id: UBERON:0001592 name: bronchial vein namespace: uberon def: "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." [Wikipedia:Bronchial_veins] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "bronchial venous tree" EXACT [] xref: EMAPA:36284 xref: FMA:4749 xref: MA:0002088 xref: NCIT:C53031 xref: SCTID:198293000 xref: UMLS:C0226650 {source="ncithesaurus:Bronchial_Vein"} xref: Wikipedia:Bronchial_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0002185 ! bronchus relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0002185 ! bronchus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001605 name: ciliary muscle namespace: uberon def: "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." [Wikipedia:Ciliary_muscle] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "Bowman`s muscles" RELATED [BTO:0000654] synonym: "ciliaris" RELATED [Wikipedia:Ciliary_muscle] synonym: "musculus ciliaris" RELATED OMO:0003011 [Wikipedia:Ciliary_muscle] synonym: "musculus ciliarus" EXACT [BTO:0000654] xref: BTO:0000654 xref: EMAPA:35240 xref: FMA:49151 xref: MA:0001269 xref: NCIT:C32315 xref: SCTID:280862009 xref: UMLS:C0559230 {source="ncithesaurus:Ciliary_Muscle"} xref: Wikipedia:Ciliary_muscle is_a: UBERON:0003386 {source="MA"} ! smooth muscle of eye is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle relationship: part_of UBERON:0001775 {source="FMA"} ! ciliary body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001606 name: muscle of iris namespace: uberon subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "iris muscle" EXACT [] synonym: "iris muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of iris" EXACT [OBOL:automatic] xref: FMA:49154 xref: MA:0001287 xref: SCTID:280888007 xref: Wikipedia:Iris_muscle is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris property_value: editor_note "revisit this, see issue #331" xsd:string property_value: UBPROP:0000008 "in aves, stromal mesenchymal cells may migrate to the iris and become skeletal" xsd:string property_value: UBPROP:0000008 "The muscle cells of the iris are smooth muscle in mammals and amphibians, but are striated muscle in birds and reptiles. Many fish have neither, and, as a result, their irides are unable to dilate and contract, so that the pupil always remains of a fixed size[Romer, via WP]" xsd:string [Term] id: UBERON:0001607 name: sphincter pupillae namespace: uberon def: "A sphincter muscle that is part of the iris." [Wikipedia:Iris_sphincter_muscle] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "circular fibers" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "constrictor pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris constrictor" RELATED [] synonym: "iris constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris sphincter muscle" EXACT [BTO:0000656] synonym: "M. sphincter pupillae" EXACT [] synonym: "m. sphincter pupillae" RELATED OMO:0003011 [Wikipedia:Iris_sphincter_muscle] synonym: "musculus sphincter pupillae" EXACT [BTO:0000656] synonym: "pupillary constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "pupillary sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "pupillary sphincter muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "sphincter muscle of pupil" EXACT [BTO:0000656] synonym: "sphincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "sphincter pupillae muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "spincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] xref: BTO:0000656 xref: EMAPA:35788 xref: FMA:49157 xref: MA:0001289 xref: NCIT:C33586 xref: SCTID:280889004 xref: UMLS:C0229189 {source="ncithesaurus:Sphincter_Pupillae_Muscle"} xref: Wikipedia:Iris_sphincter_muscle is_a: UBERON:0001606 ! muscle of iris is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle is_a: UBERON:0007521 ! smooth muscle sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: part_of UBERON:0001769 ! iris relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm relationship: has_muscle_antagonist UBERON:0001608 {source="dbpedia"} ! dilatator pupillae relationship: has_muscle_insertion UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris relationship: has_muscle_origin UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png xsd:anyURI property_value: UBPROP:0000008 "In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted]" xsd:string property_value: UBPROP:0000008 "WP says: It is found in vertebrates and some cephalopods; this class refers to the vertebrate structure" xsd:string property_value: UBPROP:0000009 "constricts iris" xsd:string [Term] id: UBERON:0001608 name: dilatator pupillae namespace: uberon def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." [Wikipedia:Iris_dilator_muscle] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "dilator muscle of pupil" EXACT [] synonym: "dilator of pupil" EXACT [] synonym: "dilator pupillae" EXACT [] synonym: "dilator pupillae muscle" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "dilator pupillae muscle" RELATED [BTO:0001371] synonym: "iris dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "iris dilator muscle" EXACT [BTO:0001371] synonym: "musculus dilatator pupillae" EXACT OMO:0003011 [FMA:49158, FMA:TA] synonym: "musculus dilatator pupillae" RELATED OMO:0003011 [Wikipedia:Iris_dilator_muscle] synonym: "musculus dilator pupillae" RELATED [BTO:0001371] synonym: "pupil dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupil dilator muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupillary dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupillary dilator muscle" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "pupillary muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "radial muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "radial muscle of iris" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "radiating fibers" RELATED [Wikipedia:Iris_dilator_muscle] xref: BTO:0001371 xref: EMAPA:35286 xref: FMA:49158 xref: MA:0001288 xref: NCIT:C32463 xref: SCTID:280890008 xref: UMLS:C0229190 {source="ncithesaurus:Dilator_Pupillae_Muscle"} xref: Wikipedia:Iris_dilator_muscle is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm relationship: has_muscle_antagonist UBERON:0001607 {source="dbpedia"} ! sphincter pupillae relationship: has_muscle_insertion UBERON:0001769 {notes="inner margins of iris", source="dbpedia"} ! iris relationship: has_muscle_origin UBERON:0001769 {notes="outer margins of iris", source="dbpedia"} ! iris relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on alpha1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina" xsd:string [Term] id: UBERON:0001612 name: facial artery namespace: uberon def: "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." [Wikipedia:Facial_artery] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria maxillaris externa" RELATED OMO:0003011 [Wikipedia:Facial_artery] synonym: "external maxillary artery" RELATED [] xref: EMAPA:19213 xref: FMA:49549 xref: MA:0001950 xref: NCIT:C32578 xref: SCTID:181328007 xref: UMLS:C0226109 {source="ncithesaurus:Facial_Artery"} xref: Wikipedia:Facial_artery is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: connecting_branch_of UBERON:0001070 ! external carotid artery intersection_of: vessel_supplies_blood_to UBERON:0001456 ! face relationship: vessel_supplies_blood_to UBERON:0001456 ! face property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001616 name: maxillary artery namespace: uberon def: "An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]." [Wikipedia:Maxillary_artery] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria maxillaris" RELATED OMO:0003011 [Wikipedia:Maxillary_artery] synonym: "internal maxillary artery" RELATED [] xref: EHDAA2:0001069 xref: EHDAA:7357 xref: EMAPA:17311 xref: FMA:49675 xref: GAID:498 xref: MA:0001919 xref: MESH:D008438 xref: NCIT:C34205 xref: SCTID:181326006 xref: UMLS:C0024949 {source="ncithesaurus:Maxillary_Artery"} xref: Wikipedia:Maxillary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1 relationship: connected_to UBERON:0001070 ! external carotid artery relationship: develops_from NCBITaxon:6072 ! Eumetazoa relationship: develops_from UBERON:0000062 ! organ relationship: develops_from UBERON:0000153 ! anterior region of body relationship: develops_from UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0001007 ! digestive system relationship: develops_from UBERON:0001009 ! circulatory system relationship: develops_from UBERON:0001041 ! foregut relationship: develops_from UBERON:0001042 ! chordate pharynx relationship: develops_from UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0003118 ! pharyngeal arch artery 1 relationship: develops_from UBERON:0004362 ! pharyngeal arch 1 relationship: develops_from UBERON:0004535 ! cardiovascular system relationship: develops_from UBERON:0004537 ! blood vasculature relationship: develops_from UBERON:0004572 ! arterial system relationship: develops_from UBERON:0007303 ! pharyngeal vasculature relationship: develops_from UBERON:0008814 ! pharyngeal arch system relationship: develops_from UBERON:0013701 ! main body axis relationship: develops_from UBERON:0013702 ! body proper relationship: develops_from UBERON:8450003 ! embryonic craniocervical region relationship: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1 relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries" xsd:string {source="http://download.videohelp.com/vitualis/med/Vascular_Devt.html"} [Term] id: UBERON:0001630 name: muscle organ namespace: uberon def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." [GO:0007517] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle" BROAD [ZFA:0005145] xref: EMAPA:37474 {source="MA:th"} xref: EV:0100146 xref: FMA:5022 xref: GAID:131 xref: galen:Muscle xref: MA:0000015 xref: SCTID:71616004 xref: TAO:0005145 xref: VHOG:0001245 xref: XAO:0000172 xref: ZFA:0005145 is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure intersection_of: UBERON:0000062 ! organ intersection_of: composed_primarily_of UBERON:0002385 ! muscle tissue relationship: composed_primarily_of UBERON:0002385 ! muscle tissue relationship: part_of UBERON:0001015 ! musculature property_value: UBPROP:0000001 "Portion of tissue composed of contractile fibers.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005145", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001245", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.75", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "muscular" xsd:string [Term] id: UBERON:0001637 name: artery namespace: uberon def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [AEO:JB] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arterial subtree" EXACT [] synonym: "arterial system" RELATED [] synonym: "arterial tree organ part" EXACT [] synonym: "arterial vessel" RELATED [] synonym: "arteries" EXACT OMO:0003004 [TAO:0000005] xref: AAO:0010211 xref: AEO:0000208 xref: BTO:0000573 xref: CALOHA:TS-0054 xref: EFO:0000814 xref: EHDAA2:0003253 xref: EMAPA:35147 xref: EV:0100026 xref: FMA:50720 xref: GAID:468 xref: galen:Artery xref: MA:0000064 xref: MAT:0000034 xref: MESH:D001158 xref: MIAA:0000034 xref: NCIT:C12372 xref: SCTID:362877004 xref: TAO:0000005 xref: UMLS:C0003842 {source="ncithesaurus:Artery"} xref: VHOG:0001251 xref: Wikipedia:Artery xref: XAO:0000114 xref: ZFA:0000005 is_a: UBERON:0003509 ! arterial blood vessel relationship: channels_from UBERON:0000948 ! heart property_value: editor_note "Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme." xsd:string property_value: UBPROP:0000001 "Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010211", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001251", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "arterial" xsd:string property_value: UBPROP:0000012 "Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system." xsd:string property_value: UBPROP:0000202 FMA:63812 [Term] id: UBERON:0001638 name: vein namespace: uberon def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [Wikipedia:Vein] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vascular element" RELATED [EMAPA:th] synonym: "vena" RELATED OMO:0003011 [Wikipedia:Vein] synonym: "venae" RELATED OMO:0003004 [VHOG:0001743] synonym: "venous subtree" BROAD [] synonym: "venous tree organ part" EXACT [] synonym: "venous vessel" BROAD [] xref: AAO:0010212 xref: AEO:0000209 xref: BTO:0000234 xref: CALOHA:TS-1108 xref: EFO:0000816 xref: EHDAA2:0003254 xref: EMAPA:35906 xref: EV:0100031 xref: FMA:50723 xref: GAID:492 xref: galen:Vein xref: MA:0000067 xref: MAT:0000037 xref: MESH:D014680 xref: MIAA:0000037 xref: NCIT:C12814 xref: SCTID:181367001 xref: TAO:0000082 xref: UMLS:C0042449 {source="ncithesaurus:Vein"} xref: VHOG:0001743 xref: Wikipedia:Vein xref: XAO:0000115 xref: ZFA:0000082 is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: channel_for UBERON:0013756 ! venous blood relationship: channel_for UBERON:0013756 ! venous blood relationship: channels_from UBERON:0001982 ! capillary property_value: editor_note "TODO - check with MA - vein vs venous blood vessel" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg xsd:anyURI property_value: UBPROP:0000001 "Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010212", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001743", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "venous" xsd:string property_value: UBPROP:0000202 FMA:63814 [Term] id: UBERON:0001639 name: hepatic portal vein namespace: uberon def: "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." [http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376, ISBN:0073040584, Wikipedia:Hepatic_portal_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic portal tree" EXACT [] synonym: "HPV" RELATED [] synonym: "liver portal vein" EXACT [OBOL:automatic] synonym: "portal vein" RELATED INCONSISTENT [] synonym: "portal vein of liver" EXACT [OBOL:automatic] synonym: "primary hepatic portal vein" RELATED [ZFA:0005090] synonym: "primary hepatic portal veins" RELATED [] synonym: "vena portae hepatis" RELATED OMO:0003011 [Wikipedia:Hepatic_portal_vein] xref: AAO:0010214 xref: FMA:50735 xref: MA:0002132 xref: TAO:0005090 xref: VHOG:0000642 xref: Wikipedia:Hepatic_portal_vein xref: ZFA:0005090 is_a: UBERON:0002017 {source="MA"} ! portal vein relationship: channels_into UBERON:0002107 ! liver relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein relationship: overlaps UBERON:0002107 ! liver relationship: part_of UBERON:0010194 ! hepatic portal system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000642", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.265", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In humans A vein in the abdominal cavity that drains blood from the gastrointestinal tract and spleen. It is usually formed by the confluence of the superior mesenteric and splenic veins, and also receives blood from the inferior mesenteric, gastric, and cystic veins. The hepatic portal vein is a major component of the hepatic portal system, one of the main portal venous systems in the body. Conditions involving the hepatic portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the hepatic portal vein. This condition, called portal hypertension, is a major complication of cirrhosis worldwide. [WP,unvetted]" xsd:string [Term] id: UBERON:0001640 name: celiac artery namespace: uberon def: "The first major branch of the abdominal aorta." [Wikipedia:Celiac_artery] comment: dorsal aorta in Kardong subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "arteria coeliaca" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "arteria cœliaca" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "celiac tree" EXACT [] synonym: "celiac trunk" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac artery" EXACT [Wikipedia:Celiac_artery] synonym: "coeliac axis" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac trunck" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac trunk" RELATED [Wikipedia:Celiac_artery] synonym: "truncus coeliacus" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "truncus cœliacus" RELATED OMO:0003011 [Wikipedia:Celiac_artery] xref: EHDAA2:0004519 xref: EMAPA:35202 xref: FMA:50737 xref: GAID:483 xref: MA:0001931 xref: MESH:D002445 xref: NCIT:C52846 xref: SCTID:181340007 xref: UMLS:C0007569 {source="ncithesaurus:Coeliac_Artery"} xref: Wikipedia:Celiac_artery is_a: UBERON:0012254 ! abdominal aorta artery relationship: develops_from UBERON:0006002 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia"} ! vitelline artery relationship: indirectly_supplies UBERON:0000160 {source="ISBN:0073040584"} ! intestine relationship: indirectly_supplies UBERON:0000945 {source="ISBN:0073040584"} ! stomach relationship: indirectly_supplies UBERON:0002106 {source="ISBN:0073040584"} ! spleen relationship: indirectly_supplies UBERON:0002107 {source="ISBN:0073040584"} ! liver property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001645 name: trigeminal nerve namespace: uberon def: "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." [ISBN:0471209627, Wikipedia:Trigeminal_nerve] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "5n" BROAD OMO:0003000 [BIRNLEX:869, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-V" RELATED [] synonym: "cranial nerve V" RELATED [] synonym: "fifth cranial nerve" EXACT [] synonym: "nerve V" RELATED [NeuroNames:549] synonym: "nervus trigeminus" EXACT OMO:0003011 [Wikipedia:Trigeminal_nerve] synonym: "nervus trigeminus" RELATED [BTO:0001072] synonym: "nervus trigeminus [v]" EXACT OMO:0003011 [FMA:50866, FMA:TA] synonym: "trigeminal nerve [V]" EXACT [] synonym: "trigeminal nerve tree" EXACT [] synonym: "trigeminal V" EXACT [EHDAA2:0002084] synonym: "trigeminal v nerve" EXACT [] synonym: "trigeminus" RELATED [BTO:0001072] xref: AAO:0010470 xref: BAMS:5n xref: BAMS:nV xref: BAMS:Vn xref: BIRNLEX:869 xref: BM:VN xref: BTO:0001072 xref: EFO:0001402 xref: EHDAA2:0002084 xref: EHDAA:3738 xref: EMAPA:17576 xref: FMA:50866 xref: GAID:726 xref: MA:0001100 xref: MBA:901 xref: MESH:D014276 xref: MFMO:0000093 xref: NCIT:C12806 xref: neuronames:549 {source="BIRNLEX:869"} xref: SCTID:362459002 xref: TAO:0000697 xref: UMLS:C0040996 {source="ncithesaurus:Trigeminal_Nerve", source="BIRNLEX:869"} xref: VHOG:0000704 xref: Wikipedia:Trigeminal_nerve xref: XAO:0003092 xref: ZFA:0000697 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus intersection_of: innervates UBERON:0000165 ! mouth intersection_of: innervates UBERON:0011648 ! jaw muscle intersection_of: innervates UBERON:1000021 ! skin of face relationship: capable_of_part_of GO:0050964 {gci_relation="part_of", gci_filler="NCBITaxon:9255", source="PMID:22179203"} ! detection of electrical stimulus involved in electroception relationship: extends_fibers_into UBERON:0002925 ! trigeminal nucleus relationship: has_developmental_contribution_from UBERON:0005239 {source="Wikipedia"} ! basal plate metencephalon relationship: innervates UBERON:0000165 ! mouth relationship: innervates UBERON:0011648 ! jaw muscle relationship: innervates UBERON:1000021 ! skin of face property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010470", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000704", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls" xsd:string {source="ISBN:0471888893"} [Term] id: UBERON:0001651 name: right pulmonary artery namespace: uberon def: "The pulmonary artery that supplies the right lung." [UBERON:cjm] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria pulmonalis dextra" RELATED OMO:0003011 [Wikipedia:Right_pulmonary_artery] synonym: "right main pulmonary artery" EXACT [] synonym: "right pulmonary arterial tree" EXACT [] xref: EMAPA:37378 {source="MA:th"} xref: FMA:50872 xref: galen:RightPulmonaryArtery xref: MA:0002500 xref: NCIT:C33489 xref: SCTID:244235003 xref: UMLS:C0923924 {source="ncithesaurus:Right_Pulmonary_Artery"} xref: Wikipedia:Right_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0002167 ! right lung relationship: connected_to UBERON:0002333 ! pulmonary trunk relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002167 ! right lung property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001652 name: left pulmonary artery namespace: uberon def: "The pulmonary artery that supplies the left lung." [UBERON:cjm] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteria pulmonalis sinistra" RELATED OMO:0003011 [Wikipedia:Left_pulmonary_artery] synonym: "left main pulmonary artery" EXACT [] synonym: "left pulmonary arterial tree" EXACT [] xref: EMAPA:37097 {source="MA:th"} xref: FMA:50873 xref: galen:LeftPulmonaryArtery xref: MA:0002032 xref: NCIT:C32971 xref: SCTID:244234004 xref: UMLS:C0923925 {source="ncithesaurus:Left_Pulmonary_Artery"} xref: Wikipedia:Left_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0002168 ! left lung relationship: connected_to UBERON:0002333 ! pulmonary trunk relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002168 ! left lung property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001653 name: facial vein namespace: uberon def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [Wikipedia:Facial_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "anterior facial vein" RELATED INCONSISTENT [Wikipedia:Facial_vein] synonym: "face vein" EXACT [OBOL:automatic] synonym: "vein of face" EXACT [OBOL:automatic] synonym: "vena facialis anterior" RELATED OMO:0003011 [Wikipedia:Facial_vein] xref: AAO:0010513 xref: EMAPA:19220 xref: FMA:50874 xref: MA:0002115 xref: NCIT:C32579 xref: SCTID:181374006 xref: UMLS:C0226532 {source="ncithesaurus:Facial_Vein"} xref: Wikipedia:Facial_vein is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0001456 ! face relationship: tributary_of UBERON:0001586 {source="FMA"} ! internal jugular vein property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010513", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000012 "MA and NCITA also has 'anterior facial vein'" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001675 name: trigeminal ganglion namespace: uberon def: "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." [http://orcid.org/0000-0002-6601-2165, http://www.ncbi.nlm.nih.gov/books/NBK53171, https://github.com/obophenotype/uberon/issues/693] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "5th ganglion" EXACT [ZFA:0000295] synonym: "fifth ganglion" EXACT [ZFA:0000295] synonym: "fused trigeminal ganglion" NARROW SENSU [NCBITaxon:32524] synonym: "ganglion of trigeminal complex" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ganglion of trigeminal nerve" RELATED [BTO:0001231] synonym: "ganglion semilunare" RELATED OMO:0003011 [Wikipedia:Trigeminal_ganglion] synonym: "ganglion trigeminale" RELATED OMO:0003011 [BTO:0001231, Wikipedia:Trigeminal_ganglion] synonym: "Gasser's ganglion" RELATED [BTO:0001231] synonym: "Gasserian ganglia" RELATED OMO:0003004 [Wikipedia:Trigeminal_ganglion] synonym: "Gasserian ganglion" EXACT [Wikipedia:Trigeminal_ganglion] synonym: "gV" RELATED [] synonym: "semilunar ganglion" EXACT [ISBN:0471888893] synonym: "trigeminal ganglia" RELATED OMO:0003004 [] synonym: "trigeminal V ganglion" EXACT [MA:0001080] synonym: "trigeminus ganglion" RELATED [] xref: AAO:0011107 xref: BAMS:5Gn xref: BAMS:GV xref: BTO:0001231 xref: EFO:0000903 xref: EHDAA2:0002085 xref: EHDAA:2113 xref: EMAPA:16797 xref: FMA:52618 xref: GAID:725 xref: MA:0001080 xref: MAT:0000511 xref: MESH:D012668 xref: NCIT:C62642 xref: neuronames:1402 xref: SCTID:244449009 xref: TAO:0000295 xref: UMLS:C0040995 {source="ncithesaurus:Trigeminal_Ganglion"} xref: VHOG:0000694 xref: Wikipedia:Trigeminal_ganglion xref: XAO:0000427 xref: XAO:0000428 xref: ZFA:0000295 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: develops_from UBERON:0006304 ! future trigeminal ganglion relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: immediate_transformation_of UBERON:0006304 {source="Bgee:AN"} ! future trigeminal ganglion property_value: editor_note "consider renaming this 'trigeminal ganglion complex'. The complex may be fused (amniotes) partially fused (xenopus) or separate (sharks)" xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/ANiknejad property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mellybelly property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png xsd:anyURI property_value: UBPROP:0000001 "A prominent collection of touch-sensory neurons of the trigeminal or fifth cranial nerve, positioned beside the brain between the eye and the ear. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000295", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "In Xenopus, the profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." xsd:string {source="PMID:21452441", source="XAO:0004093"} [Term] id: UBERON:0001676 name: occipital bone namespace: uberon def: "The bone at the lower, posterior part of the skull." [ISBN:0-683-40008-8, MP:0005269] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "occipital complex" RELATED [http://palaeos.com/vertebrates/bones/braincase/occiput.html] synonym: "occipital squama" RELATED [] synonym: "os occipitale" RELATED OMO:0003011 [Wikipedia:Occipital_bone] xref: EMAPA:25112 xref: FMA:52735 xref: GAID:227 xref: MA:0001468 xref: MESH:D009777 xref: NCIT:C12757 xref: SCTID:181796003 xref: UMLS:C0028784 {source="ncithesaurus:Occipital_Bone"} xref: Wikipedia:Occipital_bone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: connected_to UBERON:0001092 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! vertebral bone 1 relationship: connected_to UBERON:0001677 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! sphenoid bone relationship: develops_from UBERON:0003089 {source="PMID:11523816"} ! sclerotome relationship: in_taxon NCBITaxon:117570 {source="WP"} ! Teleostomi relationship: overlaps UBERON:0002241 {notes="basi paired exo and supra occipital bones", source="MA-modified"} ! chondrocranium relationship: overlaps UBERON:0003113 {notes="interparietal (postparietal)"} ! dermatocranium relationship: part_of UBERON:0005902 {source="FMA"} ! occipital region relationship: surrounds UBERON:0003687 ! foramen magnum property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII" xsd:string {source="PMID:11523816"} property_value: UBPROP:0000008 "fusion of basi-, exo- and supra-occipitals (and maybe tabular)" xsd:string {source="Kardong"} [Term] id: UBERON:0001677 name: sphenoid bone namespace: uberon def: "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." [Wikipedia:Sphenoid_bone] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "butterfly bone" RELATED [Wikipedia:Sphenoid_bone] synonym: "os sphenoidale" EXACT OMO:0003011 [FMA:52736, FMA:TA] synonym: "os sphenoidale" RELATED OMO:0003011 [Wikipedia:Sphenoid_bone] synonym: "os sphenoidum" RELATED [Wikipedia:Sphenoid_bone] synonym: "sphenoid" EXACT [] synonym: "sphenoid complex" RELATED [] synonym: "sphenoidal bone" EXACT [] xref: CALOHA:TS-2343 xref: EMAPA:18340 xref: FMA:52736 xref: GAID:230 xref: MA:0001472 xref: MESH:D013100 xref: NCIT:C12790 xref: SCTID:272676008 xref: UMLS:C0037884 {source="ncithesaurus:Sphenoid_Bone"} xref: Wikipedia:Sphenoid_bone is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0008193 {source="FMA"} ! pneumatized bone is_a: UBERON:0015060 ! sphenoid endochondral element intersection_of: UBERON:0015060 ! sphenoid endochondral element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: connected_to UBERON:0000209 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! tetrapod frontal bone relationship: connected_to UBERON:0001676 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! occipital bone relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! ethmoid bone relationship: connected_to UBERON:0002396 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! vomer relationship: develops_from UBERON:0009193 {source="cjm"} ! sphenoid cartilage element relationship: overlaps UBERON:0002241 {notes="orbito pre and basi sphenoid"} ! chondrocranium relationship: overlaps UBERON:0003113 {notes="pterygoid process"} ! dermatocranium relationship: overlaps UBERON:0008895 {notes="alisphenoid"} ! splanchnocranium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "part of viscerocranium (facial skeleton) in FMA" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001679 name: ethmoid bone namespace: uberon def: "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." [Wikipedia:Ethmoid_bone] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "ethmoid" EXACT [FMA:52740] synonym: "ethmoidal bone" EXACT [MP:0000101] synonym: "os ethmoidale" EXACT OMO:0003011 [FMA:52740, FMA:TA, Wikipedia:Ethmoid] xref: BTO:0004140 xref: EMAPA:19018 xref: FMA:52740 xref: GAID:212 xref: MA:0001483 xref: MESH:D005004 xref: NCIT:C12711 xref: SCTID:272674006 xref: UMLS:C0015027 {source="ncithesaurus:Ethmoid_Bone"} xref: VHOG:0001317 xref: Wikipedia:Ethmoid_bone is_a: UBERON:0002513 {source="ISBN:0073040584"} ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0011164 ! neurocranium bone relationship: connected_to UBERON:0000209 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! tetrapod frontal bone relationship: connected_to UBERON:0001677 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! sphenoid bone relationship: connected_to UBERON:0002396 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! vomer relationship: contributes_to_morphology_of UBERON:0011156 ! facial skeleton relationship: develops_from UBERON:0006227 {evidence="definitional"} ! ethmoid bone primordium relationship: part_of UBERON:0002517 ! basicranium relationship: part_of UBERON:0011241 ! ethmoid region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001317", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/ethmoid+bone"} property_value: UBPROP:0000003 "The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001317", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.259", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "ethmoidal" xsd:string property_value: UBPROP:0000008 "todo - homology e.g. mesethmoid of teleost" xsd:string property_value: UBPROP:0000012 "Note the WP states the Neurocranium contains the ethmoid bone, both MA and FMA place the ethmoid as part of the viscerocranium. FMA also has it in neurocranium (via basicranium). Ideally we would have non-overlapping divisions of the skull, but for now we follow FMA" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001697 name: orbit of skull namespace: uberon def: "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." [http://orcid.org/0000-0002-6601-2165, TAO:0001410, Wikipedia:Orbit_(anatomy)] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bony orbit" EXACT [] synonym: "eye socket" EXACT [] synonym: "orbit" RELATED [ZFA:0001410] synonym: "orbit of skull" EXACT [FMA:53074] xref: BTO:0004687 xref: FMA:53074 xref: GAID:223 xref: galen:Orbit xref: MA:0002482 xref: MESH:D009915 xref: NCIT:C12347 xref: TAO:0001410 xref: UMLS:C0029180 {source="ncithesaurus:Orbit"} xref: Wikipedia:Orbit_(anatomy) xref: XAO:0003171 xref: ZFA:0001410 is_a: UBERON:0010912 ! subdivision of skeleton is_a: UBERON:0015212 ! lateral structure relationship: in_lateral_side_of UBERON:0011156 {source="FMA-abduced-lr"} ! facial skeleton relationship: location_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0004088 ! orbital region relationship: part_of UBERON:0011156 ! facial skeleton property_value: UBPROP:0000001 "Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001410", ontology="TAO", source="TAO:MAH"} property_value: UBPROP:0000012 "in FMA, this overlaps with bones such as the maxilla and sphenoid; in ZFA, individual bones are part of the orbit" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001703 name: neurocranium namespace: uberon def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." [PMID:11523816, TAO:MAH, Wikipedia:Neuroranium, ZFA:0001580] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "brain box" EXACT [] synonym: "brain case" RELATED [ZFA:0001580] synonym: "brain pan" RELATED [http://www.thefreedictionary.com/braincase] synonym: "braincase" RELATED [ZFA:0001580] xref: FMA:53672 xref: MA:0000317 xref: SCTID:361731002 xref: TAO:0001580 xref: Wikipedia:Neuroranium xref: XAO:0003170 xref: ZFA:0001580 is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull relationship: develops_from UBERON:0004761 ! cartilaginous neurocranium relationship: location_of UBERON:0000955 ! brain relationship: part_of UBERON:0003128 ! cranium relationship: protects UBERON:0000955 ! brain property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical cluster that consists of the cartilages and bones that surround the brain.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001580", ontology="TAO", source="TAO:MAH"} property_value: UBPROP:0000007 "neurocranial" xsd:string property_value: UBPROP:0000010 "It includes the following bones: Ethmoid bone, Frontal bone, Occipital bone, Parietal bone, Sphenoid bone, Temporal bone. The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton" xsd:string property_value: UBPROP:0000011 "The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]." xsd:string {source="WP"} property_value: UBPROP:0000012 "It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ..." xsd:string {external_ontology="MA"} [Term] id: UBERON:0001708 name: jaw skeleton namespace: uberon def: "Subdivision of skeleton which includes upper and lower jaw skeletons." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Jaw] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior splanchnocranium" RELATED [] synonym: "jaw" EXACT [MA:0001905] synonym: "jaw cartilage" EXACT [ZFA:0001227] synonym: "jaws" RELATED [] synonym: "mandibular arch" RELATED [TAO:0001227] synonym: "mandibular arch skeleton" EXACT [ZFA:0001227] synonym: "oral jaw skeleton" RELATED [] synonym: "pharyngeal arch 1 skeleton" RELATED [] synonym: "visceral arch 1" RELATED [] xref: AAO:0000988 xref: BTO:0001749 xref: EMAPA:35455 xref: FMA:54396 xref: GAID:214 xref: galen:Jaw xref: MA:0001905 xref: MESH:D007568 xref: NCIT:C48821 xref: SCTID:181811001 xref: TAO:0001227 xref: UMLS:C0022359 {source="ncithesaurus:Jaw"} xref: Wikipedia:Jaw xref: ZFA:0001227 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0011595 ! jaw region relationship: capable_of NBO:0000073 ! chewing relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: overlaps UBERON:0008895 ! splanchnocranium relationship: part_of UBERON:0011156 {source="cjm"} ! facial skeleton relationship: part_of UBERON:0011595 ! jaw region relationship: skeleton_of UBERON:0011595 ! jaw region property_value: editor_note "TODO - move ZFA:0001227 (it is the entire jaw skeleton)." xsd:string property_value: UBPROP:0000001 "Skeletal and cartilage elements of the first pharyngeal arch.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001227", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000011 "There are cellular contributions from all three embryonic germ layers: pharyngeal mesoderm, endoderm and neural crest that migrates out of the ectoderm (Noden, 1983)." xsd:string property_value: UBPROP:0000012 "in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001709 name: upper jaw region namespace: uberon def: "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Upper_jaw] comment: See notes for jaw w.r.t skeletal element vs subdivision of head. subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "alveolodental arch of bimaxilla" RELATED [FMA:59399] synonym: "dorsal mandibular arch" RELATED [] synonym: "dorsal pharyngeal arch 1" RELATED INCONSISTENT [] synonym: "maxillary part of mouth" EXACT [FMA:59399] synonym: "maxillary part of mouth proper" RELATED [FMA:59399] synonym: "palatoquadrate arch" RELATED INCONSISTENT [] synonym: "upper pharyngeal jaws" RELATED [] xref: AAO:0000620 xref: EHDAA2:0002118 xref: EHDAA2:0004607 xref: EHDAA:8025 xref: EMAPA:17924 xref: FMA:59399 xref: ncithesaurus:Upper_Jaw xref: SCTID:362636001 xref: VHOG:0000454 xref: Wikipedia:Upper_jaw is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: has_skeleton UBERON:0003277 ! skeleton of upper jaw disjoint_from: UBERON:0001710 ! lower jaw region relationship: has_skeleton UBERON:0003277 ! skeleton of upper jaw relationship: part_of UBERON:0004089 ! midface relationship: part_of UBERON:0011595 ! jaw region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png xsd:anyURI property_value: RO:0002171 UBERON:0001710 property_value: UBPROP:0000001 "Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000620", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000454", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "Note isa/partof difference MA/FMA" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001710 name: lower jaw region namespace: uberon def: "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [Wikipedia:Lower_jaw] comment: See notes for jaw w.r.t skeletal element vs subdivision of head subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "lower part of mouth" RELATED [] synonym: "mandibular part of mouth" EXACT [FMA:59398] synonym: "mandibular series" RELATED [] xref: AAO:0000272 xref: EFO:0003660 xref: EHDAA2:0001018 xref: EHDAA:7995 xref: EMAPA:17906 xref: FMA:59398 xref: MESH:D008334 xref: ncithesaurus:Lower_Jaw xref: SCTID:362637005 xref: VHOG:0000453 xref: Wikipedia:Lower_jaw is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: has_skeleton UBERON:0003278 ! skeleton of lower jaw relationship: develops_from UBERON:0005867 {source="Wikipedia:Mandibular_prominence"} ! mandibular prominence relationship: has_skeleton UBERON:0003278 ! skeleton of lower jaw relationship: part_of UBERON:0011595 ! jaw region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png xsd:anyURI property_value: RO:0002171 UBERON:0001709 property_value: UBPROP:0000001 "Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000272", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000453", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "Note isa/partof difference MA/FMA" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001714 name: cranial ganglion namespace: uberon alt_id: UBERON:0003213 alt_id: UBERON:0026601 def: "The groups of nerve cell bodies associated with the twelve cranial nerves." [ISBN:0-683-40008-8, MGI:csmith, MP:0001081, PMID:9362461] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cranial ganglia" RELATED [] synonym: "cranial ganglion" EXACT [] synonym: "cranial ganglion part of peripheral nervous system" EXACT [BIRNLEX:2597] synonym: "cranial ganglion/nerve" EXACT [] synonym: "cranial nerve ganglion" EXACT [] synonym: "cranial neural ganglion" EXACT [] synonym: "cranial neural tree organ ganglion" EXACT [OBOL:automatic] synonym: "ganglion of cranial nerve" EXACT [FMA:54502] synonym: "ganglion of cranial neural tree organ" EXACT [OBOL:automatic] synonym: "head ganglion" RELATED [] synonym: "presumptive cranial ganglia" RELATED [ZFA:0000013] xref: BIRNLEX:2597 xref: BTO:0000106 xref: EFO:0000902 xref: EMAPA:16659 xref: FMA:54502 xref: MA:0000213 xref: MA:0000214 xref: MAT:0000200 xref: MIAA:0000200 xref: SCTID:244448001 xref: TAO:0000013 xref: VHOG:0000076 xref: Wikipedia:Cranial_nerve_ganglion xref: XAO:0000027 xref: ZFA:0000013 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle relationship: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0000033 ! head property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Ganglion which is located in the head.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000013", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001731 name: cavity of pharynx namespace: uberon def: "An anatomical space that is enclosed by a pharynx." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavitas pharyngealis" RELATED OMO:0003011 [] synonym: "cavitas pharyngis" RELATED [BTO:0002097] synonym: "lumen of pharynx" EXACT [] synonym: "pharyngeal cavity" EXACT [] xref: AAO:0010435 xref: BSA:0000113 xref: BTO:0002097 xref: EMAPA:18381 xref: FMA:54935 xref: SCTID:180543003 xref: XAO:0000105 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: luminal_space_of UBERON:0006562 ! pharynx relationship: develops_from UBERON:0001041 {source="XAO"} ! foregut relationship: luminal_space_of UBERON:0006562 ! pharynx relationship: part_of UBERON:0006562 ! pharynx property_value: UBPROP:0000008 "See notes for pharynx - as a grouping class this is probably too bad. We exclude WBbt:0005790 (pharyngeal lumen) because of the developmental relationship" xsd:string property_value: UBPROP:0000011 "TOODO check" xsd:string [Term] id: UBERON:0001766 name: anterior chamber of eyeball namespace: uberon def: "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." [MESH:A09.371.060.067, MP:0005205] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "anterior chamber" EXACT [HP:0000593, MP:0010709] synonym: "anterior chamber of eye" EXACT [] synonym: "camera anterior" EXACT [] synonym: "camera anterior bulbi" RELATED [BTO:0002084] synonym: "camera anterior bulbi oculi" RELATED OMO:0003011 [Wikipedia:Anterior_chamber_of_eyeball] synonym: "camera oculi anterior" RELATED [BTO:0002084] synonym: "eye anterior chamber" EXACT [] xref: BTO:0002084 xref: EHDAA2:0000129 xref: EHDAA:9033 xref: EMAPA:18231 xref: FMA:58078 xref: GAID:889 xref: MA:0000262 xref: MESH:D000867 xref: NCIT:C12667 xref: SCTID:181160009 xref: UMLS:C0003151 {source="ncithesaurus:Anterior_Chamber_of_the_Eye"} xref: VHOG:0001431 xref: Wikipedia:Anterior_chamber_of_eyeball is_a: UBERON:0006311 {source="FMA"} ! chamber of eyeball relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball relationship: part_of UBERON:0001801 ! anterior segment of eyeball property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: UBPROP:0000001 "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001431", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/anterior+chamber"} property_value: UBPROP:0000012 "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0001768 name: uvea namespace: uberon def: "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." [MP:0005197, Wikipedia:Uvea] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pars iridica retinae" RELATED [Wikipedia:Uvea] synonym: "tunica vasculatis oculi" RELATED [Wikipedia:Uvea] synonym: "tunica vasculosa bulbi" RELATED OMO:0003011 [Wikipedia:Uvea] synonym: "tunica vasculosa of eyeball" EXACT [FMA:58103] synonym: "uvea" EXACT [FMA:58103] synonym: "uveal tract" EXACT [FMA:58103] synonym: "vascular layer of eyeball" RELATED [FMA:58103] xref: CALOHA:TS-2228 xref: EMAPA:35901 xref: FMA:58103 xref: GAID:912 xref: MA:0002480 xref: MESH:D014602 xref: NCIT:C12811 xref: SCTID:280648000 xref: UMLS:C0042160 {source="ncithesaurus:Uvea"} xref: Wikipedia:Uvea is_a: UBERON:0004923 {source="FMA"} ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part UBERON:0001769 ! iris relationship: has_part UBERON:0001775 ! ciliary body relationship: has_part UBERON:0001776 ! optic choroid relationship: part_of UBERON:0000019 ! camera-type eye property_value: editor_note "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png xsd:anyURI property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: UBPROP:0000007 "uveal" xsd:string [Term] id: UBERON:0001769 name: iris namespace: uberon def: "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." [ISBN:0-683-40008-8, MP:0001322] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior uvea" RELATED [] synonym: "irides" RELATED OMO:0003004 [] synonym: "irises" RELATED OMO:0003004 [VHOG:0000101] xref: AAO:0010347 xref: BTO:0000653 xref: CALOHA:TS-0491 xref: EFO:0004245 xref: EMAPA:19154 xref: EV:0100345 xref: FMA:58235 xref: GAID:917 xref: MA:0000273 xref: MESH:D007498 xref: NCIT:C12737 xref: SCTID:181164000 xref: TAO:0001238 xref: UMLS:C0022077 {source="ncithesaurus:Iris"} xref: VHOG:0000101 xref: Wikipedia:Iris_(anatomy) xref: XAO:0000185 xref: ZFA:0001238 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0011892 ! anterior uvea relationship: develops_from UBERON:0004128 {source="XAO"} ! optic vesicle relationship: part_of UBERON:0011892 ! anterior uvea property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000101", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000101", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "iridial" xsd:string property_value: UBPROP:0000008 "The avian iris and ciliary body undergoes a transition from smooth-to-striated muscle during embryonic development [DOI:dx.doi.org/10.1006/dbio.1998.9019]" xsd:string [Term] id: UBERON:0001772 name: corneal epithelium namespace: uberon def: "The smooth stratified squamous epithelium that covers the outer surface of the cornea." [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior corneal epithelium" EXACT [] synonym: "anterior endothelium of cornea" RELATED [BTO:0000287] synonym: "cornea epithelial tissue" EXACT [OBOL:automatic] synonym: "cornea epithelium" EXACT [OBOL:automatic] synonym: "e. anterius corneae" RELATED OMO:0003011 [Wikipedia:Corneal_epithelium] synonym: "endothelium anterius corneae" RELATED [BTO:0000287] synonym: "endothelium camerae anterioris bulbi" RELATED [BTO:0000287] synonym: "endothelium corneale" RELATED [BTO:0000287] synonym: "epithelial tissue of cornea" EXACT [OBOL:automatic] synonym: "epithelium anterius (cornea)" EXACT [] synonym: "epithelium anterius corneae" EXACT OMO:0003011 [FMA:58263, FMA:TA] synonym: "epithelium corneæ anterior layer" EXACT [] synonym: "epithelium of cornea" EXACT [] synonym: "epithelium posterius corneae" RELATED [BTO:0000287] synonym: "external epithelium of cornea" EXACT [] xref: BTO:0000287 xref: CALOHA:TS-0173 xref: EFO:0001917 xref: EHDAA2:0000319 xref: EMAPA:17162 xref: FMA:58263 xref: GAID:895 xref: MA:0001243 xref: MESH:D019573 xref: NCIT:C12928 xref: SCTID:368825001 xref: TAO:0002187 xref: UMLS:C0459875 {source="ncithesaurus:Corneal_Epithelium"} xref: Wikipedia:Corneal_epithelium xref: ZFA:0001683 is_a: UBERON:0000488 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! atypical epithelium is_a: UBERON:0010304 {gci_relation="part_of", gci_filler="NCBITaxon:7955"} ! non-keratinized stratified squamous epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: bounding_layer_of UBERON:0000964 ! cornea relationship: bounding_layer_of UBERON:0000964 ! cornea relationship: contributes_to_morphology_of UBERON:0000964 ! cornea relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm relationship: part_of UBERON:0000964 ! cornea property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002187", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"} property_value: UBPROP:0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei" xsd:string property_value: UBPROP:0000008 "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" xsd:string [Term] id: UBERON:0001773 name: sclera namespace: uberon def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." [Wikipedia:Sclera, ZFIN:ZDB-PUB-050701-15] comment: Disease notes: implicated in rheumatoid arthritis. subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "scleral capsule" RELATED [] xref: AAO:0010354 xref: BTO:0001606 xref: EMAPA:19027 xref: EV:0100342 xref: FMA:58269 xref: GAID:911 xref: MA:0000280 xref: MESH:D012590 xref: NCIT:C12784 xref: SCTID:181163006 xref: UMLS:C0036410 {source="ncithesaurus:Sclera"} xref: VHOG:0001274 xref: Wikipedia:Sclera xref: XAO:0000183 xref: ZFA:0005563 is_a: UBERON:0000064 ! organ part relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0003314 {source="ISBN:0781772214"} ! eye mesenchyme relationship: develops_from UBERON:0007213 {inferred_by="cjm", source="ISBN:0781772214", source="Wikipedia"} ! mesenchyme derived from head neural crest relationship: has_part CL:0000347 {source="ZFA"} ! scleral cell relationship: has_quality PATO:0000963 ! opaque relationship: part_of UBERON:0012430 {source="FMA"} ! tunica fibrosa of eyeball property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]." xsd:string {source="Wikipedia:Sclera"} property_value: UBPROP:0000001 "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001274", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sclera"} property_value: UBPROP:0000007 "scleral" xsd:string property_value: UBPROP:0000008 "in fish, reptiles and monotremes the connective tissue of the sclera is skeletal" xsd:string property_value: UBPROP:0000010 "continuous with the dura mater and the cornea; The sclera forms the posterior five-sixths of the connective tissue coat of the globe." xsd:string property_value: UBPROP:0000011 "Majority derives from NC that surrounds optic cup of neurectoderm; a small temporal portion develops from the mesoderm that contributes to striated extra-ocular muscles and vascular endothelia[Rada&Johnson]." xsd:string property_value: UBPROP:0000011 "Seko et al demonstrate chondrogenic potential and identify this as connective tissue[DOI:10.1371/journal.pone.0003709]." xsd:string [Term] id: UBERON:0001774 name: skeletal muscle of trunk namespace: uberon def: "A skeletal muscle organ that is part of the trunk region." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "body musculature" EXACT [ZFA:0000473] synonym: "muscle of trunk" EXACT [FMA:58274] synonym: "muscle organ of torso" EXACT [OBOL:automatic] synonym: "muscle organ of trunk" EXACT [OBOL:automatic] synonym: "torso muscle organ" EXACT [OBOL:automatic] synonym: "trunk muscle" EXACT [] synonym: "trunk muscle organ" EXACT [OBOL:automatic] synonym: "trunk musculature" EXACT [] xref: AAO:0000611 xref: EMAPA:35888 xref: FMA:58274 xref: MA:0000514 xref: TAO:0000473 xref: XAO:0003230 xref: ZFA:0000473 is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0004479 {source="prolog"} ! musculature of trunk property_value: editor_note "Note that this class excludes smooth muscle elements in the trunk region, such as the internal anal sphincter. This appears to be consistent with other ontologies such as FMA and ZFA which appear to only include skeletal muscles here. In fact the MA class 'trunk muscle' is classified as a 'set of skeletal muscles'." xsd:string property_value: UBPROP:0000012 "Many ontologies do not appear to have a coherent distinction between an individual muscle and the musculature (i.e. the set of muscles in a region), so we group all together here." xsd:string [Term] id: UBERON:0001775 name: ciliary body namespace: uberon def: "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." [ISBN:0-683-40008-8, MP:0005099, Wikipedia:Ciliary_body] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior uvea" RELATED [] synonym: "ciliary bodies" RELATED OMO:0003004 [VHOG:0000102] synonym: "corpus ciliare" RELATED OMO:0003011 [Wikipedia:Ciliary_body] synonym: "ocular ciliary body" EXACT [] xref: AAO:0010341 xref: BTO:0000260 xref: CALOHA:TS-0694 xref: EMAPA:19065 xref: EV:0100346 xref: FMA:58295 xref: GAID:916 xref: MA:0000264 xref: MESH:D002924 xref: NCIT:C12345 xref: neuronames:1571 xref: SCTID:263340007 xref: UMLS:C0008779 {source="ncithesaurus:Ciliary_Body"} xref: VHOG:0000102 xref: Wikipedia:Ciliary_body xref: XAO:0000186 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: contributes_to_morphology_of UBERON:0011892 ! anterior uvea relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm relationship: has_part UBERON:0001605 ! ciliary muscle relationship: has_part UBERON:0010427 ! ciliary processes relationship: part_of UBERON:0011892 ! anterior uvea property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001776 name: optic choroid namespace: uberon def: "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [Wikipedia:Choroid] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "chorioid" RELATED [BTO:0001829] synonym: "choroid" EXACT [MA:0000263] synonym: "choroid coat" EXACT [Wikipedia:Choroid] synonym: "choroidea" EXACT [Wikipedia:Choroid] synonym: "choroidea" RELATED OMO:0003011 [Wikipedia:Choroid] synonym: "eye choroid" EXACT [VHOG:0001568] synonym: "optic choroid" RELATED [ZFA:0005229] synonym: "posterior uvea" EXACT [Wikipedia:Uvea#Regions] xref: BTO:0001829 xref: CALOHA:TS-2054 xref: EMAPA:19077 xref: EV:0100347 xref: FMA:58298 xref: GAID:913 xref: MA:0000263 xref: MESH:D002829 xref: NCIT:C12344 xref: SCTID:181172003 xref: TAO:0005229 xref: UMLS:C0008520 {source="ncithesaurus:Choroid"} xref: VHOG:0001568 xref: Wikipedia:Choroid xref: ZFA:0005229 is_a: UBERON:0002203 ! vasculature of eye disjoint_from: UBERON:0011892 {source="lexical"} ! anterior uvea relationship: adjacent_to UBERON:0000966 ! retina relationship: adjacent_to UBERON:0001773 ! sclera relationship: adjacent_to UBERON:0011892 ! anterior uvea relationship: contributes_to_morphology_of UBERON:0001768 ! uvea relationship: overlaps UBERON:0001802 {source="Wikipedia"} ! posterior segment of eyeball relationship: part_of UBERON:0001768 {source="MA"} ! uvea relationship: part_of UBERON:0019207 ! chorioretinal region property_value: editor_note "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "choroidal" xsd:string property_value: UBPROP:0000012 "MP treats posterior uvea and optic choroid as distinct" xsd:string {external_ontology="MP"} [Term] id: UBERON:0001777 name: substantia propria of cornea namespace: uberon def: "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." [ISBN:0-683-40008-8, MESH:A09.371.060.217.228, MP:0005300] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corneal stroma" EXACT [MA:0001245] synonym: "stroma of cornea" EXACT [] synonym: "substantia propria" BROAD [] synonym: "substantia propria corneae" EXACT OMO:0003011 [FMA:58306, FMA:TA] xref: CALOHA:TS-1138 xref: EFO:0002514 xref: EMAPA:17602 xref: FMA:58306 xref: GAID:893 xref: MA:0001245 xref: MESH:D003319 xref: NCIT:C12699 xref: SCTID:362511000 xref: TAO:0002189 xref: UMLS:C0010040 {source="ncithesaurus:Corneal_Stroma"} xref: Wikipedia:Corneal_stroma xref: ZFA:0001685 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0000964 ! cornea relationship: adjacent_to UBERON:0004367 ! Descemet's membrane relationship: adjacent_to UBERON:0004370 ! anterior limiting lamina of cornea relationship: contributes_to_morphology_of UBERON:0000964 ! cornea relationship: develops_from UBERON:0007213 {inferred_by="cjm", source="ISBN:0781772214", source="Wikipedia"} ! mesenchyme derived from head neural crest relationship: part_of UBERON:0000964 ! cornea property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png xsd:anyURI property_value: UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"} property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"} property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"} [Term] id: UBERON:0001778 name: ciliary epithelium namespace: uberon def: "A double layer covering the ciliary body that produces aqueous humor." [Wikipedia:Ciliary_body#Ciliary_epithelium] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ciliary body epithelium" EXACT [FMA:58464] synonym: "epithelium of ciliary body" EXACT [FMA:58464] synonym: "ocular ciliary epithelium" EXACT [] xref: BTO:0001770 xref: CALOHA:TS-0695 xref: EMAPA:35239 xref: FMA:58464 xref: MA:0001238 xref: NCIT:C32314 xref: SCTID:280870004 xref: UMLS:C0459736 {source="ncithesaurus:Ciliary_Epithelium"} xref: Wikipedia:Ciliary_body#Ciliary_epithelium is_a: UBERON:0000488 {source="FMA"} ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001775 ! ciliary body relationship: has_part GO:0048770 {source="MP"} ! pigment granule relationship: part_of UBERON:0001775 {source="MA"} ! ciliary body relationship: produces UBERON:0001796 {source="Wikipedia"} ! aqueous humor of eyeball property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001779 name: iris stroma namespace: uberon def: "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." [http://www.drugs.com/dict/stroma-of-iris.html, Wikipedia:Iris_stroma] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "iridial stroma" EXACT [] synonym: "stroma of iris" EXACT [] xref: EMAPA:35451 xref: FMA:58526 xref: MA:0002777 xref: SCTID:280882008 xref: Wikipedia:Iris_stroma xref: ZFA:0005569 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0001769 ! iris relationship: contributes_to_morphology_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png xsd:anyURI [Term] id: UBERON:0001780 name: spinal nerve namespace: uberon def: "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." [MESH:A08.800.800.720, MP:0001077] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "backbone nerve" EXACT [OBOL:automatic] synonym: "nerve of backbone" EXACT [OBOL:automatic] synonym: "nerve of spinal column" EXACT [OBOL:automatic] synonym: "nerve of spine" EXACT [OBOL:automatic] synonym: "nerve of vertebral column" EXACT [OBOL:automatic] synonym: "nervi spinales" RELATED OMO:0003011 [Wikipedia:Spinal_nerve] synonym: "spinal column nerve" EXACT [OBOL:automatic] synonym: "spinal nerve tree" EXACT [] synonym: "spinal nerves" RELATED OMO:0003004 [BAMS:spin] synonym: "spine nerve" EXACT [OBOL:automatic] synonym: "vertebral column nerve" EXACT [OBOL:automatic] xref: AAO:0011101 xref: BAMS:spin xref: BTO:0000870 xref: EHDAA2:0001898 xref: EMAPA:16989 xref: FMA:5858 xref: GAID:841 xref: MA:0000233 xref: MESH:D013127 xref: NCIT:C12792 xref: neuronames:1228 xref: SCTID:361099009 xref: UMLS:C0037941 {source="ncithesaurus:Spinal_Nerve"} xref: VHOG:0000824 xref: Wikipedia:Spinal_nerve xref: XAO:0003101 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0002240 ! spinal cord relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000824", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/spinal+nerve"} [Term] id: UBERON:0001781 name: layer of retina namespace: uberon def: "Any of the layers that make up the retina[MP]." [MP:0003727] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "retina layer" EXACT [] synonym: "retina neuronal layer" EXACT [MP:0006069] synonym: "retinal layer" EXACT [] synonym: "retinal neuronal layer" EXACT [MP:0006069] xref: AAO:0010353 xref: EMAPA:35742 xref: FMA:58617 xref: MA:0001319 xref: NCIT:C49328 xref: SCTID:280657006 xref: UMLS:C0459649 {source="ncithesaurus:Retina_Layer"} xref: XAO:0000266 is_a: UBERON:0022303 ! nervous system cell part layer relationship: contributes_to_morphology_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina property_value: UBPROP:0000012 "MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001785 name: cranial nerve namespace: uberon def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." [Wikipedia:Cranial_nerve] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cranial nerves" RELATED [] synonym: "cranial neural tree organ" EXACT [] synonym: "nervus cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_nerve] xref: AAO:0000108 xref: BAMS:cran xref: BIRNLEX:1623 xref: BTO:0001104 xref: EHDAA2:0000323 xref: EMAPA:17264 xref: FMA:5865 xref: GAID:802 xref: MA:0000215 xref: MBA:967 xref: MESH:D003391 xref: NCIT:C12700 xref: neuronames:1227 xref: SCTID:244447006 xref: TAO:0000641 xref: UMLS:C0010268 {source="BIRNLEX:1623", source="ncithesaurus:Cranial_Nerve"} xref: UMLS:C1269897 {source="BIRNLEX:1623"} xref: VHOG:0000279 xref: Wikipedia:Cranial_nerve xref: XAO:0000429 xref: XAO:0003089 xref: ZFA:0000641 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0001021 ! nerve intersection_of: anterior_to UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0000955 ! brain relationship: anterior_to UBERON:0001780 ! spinal nerve relationship: has_developmental_contribution_from UBERON:0003099 ! cranial neural crest property_value: editor_note "classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN." xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000641", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000279", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6" xsd:string [Term] id: UBERON:0001796 name: aqueous humor of eyeball namespace: uberon def: "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." [Wikipedia:Aqueous_humor] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "aqueous humor" EXACT [] synonym: "aqueous humour" EXACT [EHDAA2:0000139] synonym: "humor aquosus" EXACT OMO:0003011 [FMA:58819, FMA:TA] xref: EHDAA2:0000139 xref: EHDAA:10196 xref: EMAPA:18232 xref: ENVO:02000024 xref: FMA:58819 xref: GAID:890 xref: MA:0001236 xref: MESH:D001082 xref: NCIT:C13190 xref: SCTID:280587006 xref: UMLS:C0003662 {source="ncithesaurus:Aqueous_Humor"} xref: VHOG:0000548 xref: Wikipedia:Aqueous_humor xref: ZFA:0005564 is_a: UBERON:0006312 ! ocular refractive media is_a: UBERON:0006314 ! bodily fluid relationship: contributes_to_morphology_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 {notes="FMA def states A and P", notes="located_in in EHDAA2", source="VHOG"} ! anterior chamber of eyeball property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: UBPROP:0000001 "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aqueous+humour"} property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001800 name: sensory ganglion namespace: uberon def: "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." [MP:0000960] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "ganglion sensorium" EXACT OMO:0003011 [] xref: AEO:0001000 xref: BTO:0005630 xref: EMAPA:36596 xref: FMA:5885 xref: MA:0002566 xref: MESH:D017950 xref: NCIT:C13060 xref: UMLS:C0206429 {source="ncithesaurus:Sensory_Ganglion"} is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001027 ! sensory nerve relationship: extends_fibers_into UBERON:0001027 ! sensory nerve relationship: part_of RO:0002577 ! system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001801 name: anterior segment of eyeball namespace: uberon def: "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." [ISBN:0-683-40008-8, MESH:A09.371.060, MP:0005193] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "anterior eye segment" EXACT [] synonym: "anterior segment eye" EXACT [ZFA:0005566] synonym: "anterior segment of eye" EXACT [] synonym: "anterior segment of the eye" EXACT [] synonym: "eye anterior segment" EXACT [] synonym: "segmentum anterius (bulbus oculi)" EXACT [] synonym: "segmentum anterius bulbi oculi" RELATED OMO:0003011 [Wikipedia:Anterior_segment_of_eyeball] xref: EMAPA:36594 xref: FMA:58865 xref: MA:0002484 xref: MESH:D000869 xref: NCIT:C12668 xref: SCTID:280658001 xref: UMLS:C0003153 {source="ncithesaurus:Anterior_Eye_Segment"} xref: Wikipedia:Anterior_segment_of_eyeball xref: ZFA:0005566 is_a: UBERON:0000063 ! organ subunit disjoint_from: UBERON:0001802 {source="lexical"} ! posterior segment of eyeball relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: in_anterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png xsd:anyURI property_value: RO:0002171 UBERON:0001802 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} [Term] id: UBERON:0001802 name: posterior segment of eyeball namespace: uberon def: "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." [ISBN:0-683-40008-8, MP:0005195] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "eye posterior segment" EXACT [] synonym: "posterior eye segment" EXACT [] synonym: "posterior segment eye" EXACT [ZFA:0005567] synonym: "posterior segment of eye" EXACT [] synonym: "posterior segment of the eye" EXACT [] synonym: "segmentum posterius (bulbus oculi)" EXACT [] synonym: "segmentum posterius bulbi oculi" RELATED OMO:0003011 [Wikipedia:Posterior_segment_of_eyeball] xref: EMAPA:36595 xref: FMA:58868 xref: MA:0002485 xref: NCIT:C12906 xref: SCTID:280659009 xref: UMLS:C0278450 {source="ncithesaurus:Posterior_Eye_Segment"} xref: Wikipedia:Posterior_segment_of_eyeball xref: ZFA:0005567 is_a: UBERON:0000063 ! organ subunit relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: in_posterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI [Term] id: UBERON:0001803 name: epithelium of lens namespace: uberon def: "A layer of epithelial cells that is part of the eye." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "epithelial tissue of eye lens" EXACT [OBOL:automatic] synonym: "epithelial tissue of lens" EXACT [OBOL:automatic] synonym: "epithelium lentis" EXACT OMO:0003011 [FMA:58871, FMA:TA] synonym: "epithelium of eye lens" EXACT [OBOL:automatic] synonym: "eye lens epithelial tissue" EXACT [OBOL:automatic] synonym: "eye lens epithelium" EXACT [OBOL:automatic] synonym: "lens epithelial tissue" EXACT [OBOL:automatic] synonym: "lens epithelium" EXACT [] xref: BTO:0001873 xref: CALOHA:TS-0543 xref: EMAPA:32871 xref: FMA:58871 xref: MA:0001301 xref: SCTID:362523006 xref: TAO:0001326 xref: Wikipedia:Lens_(anatomy)#Lens_Epithelium xref: XAO:0004094 xref: ZFA:0001326 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000965 ! lens of camera-type eye relationship: contributes_to_morphology_of UBERON:0000965 ! lens of camera-type eye relationship: part_of UBERON:0000965 ! lens of camera-type eye property_value: IAO:0000232 "this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001804 name: capsule of lens namespace: uberon def: "The elastic, clear, membrane-like structure, that is outer most layer of the lens." [MGI:smb, MP:0003236, PMID:15483628] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "capsula lentis" EXACT OMO:0003011 [] synonym: "lens capsule" EXACT [] xref: EHDAA2:0000977 xref: EMAPA:18237 xref: FMA:58881 xref: MA:0001300 xref: NCIT:C32975 xref: SCTID:244500004 xref: UMLS:C0229232 {source="ncithesaurus:Lens_Capsule"} xref: VHOG:0000550 xref: Wikipedia:Lens_(anatomy)#Lens_capsule xref: ZFA:0005574 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005764 ! acellular membrane intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: bounding_layer_of UBERON:0000965 ! lens of camera-type eye relationship: bounding_layer_of UBERON:0000965 ! lens of camera-type eye relationship: develops_from UBERON:0005614 {source="EHDAA2"} ! lens anterior epithelium relationship: has_part CHEBI:35722 ! sulfated glycosaminoglycan relationship: has_part GO:0005587 ! collagen type IV trimer relationship: has_quality PATO:0000964 ! transparent relationship: part_of UBERON:0000965 ! lens of camera-type eye property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png xsd:anyURI property_value: UBPROP:0000001 "The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000550", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000550", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"} property_value: UBPROP:0000010 "synthesized by the lens epithelium and its main components are Type IV collagen and sulfated glycosaminoglycans (GAGs). [Wikipedia:Capsule_of_lens" xsd:string property_value: UBPROP:0000012 "FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001805 name: autonomic ganglion namespace: uberon def: "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." [Wikipedia:Autonomic_ganglion] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "autonomic nervous system ganglion" EXACT [OBOL:automatic] synonym: "ganglion autonomicum" RELATED OMO:0003011 [Wikipedia:Autonomic_ganglion] synonym: "ganglion of autonomic nervous system" EXACT [OBOL:automatic] synonym: "ganglion of visceral nervous system" EXACT [OBOL:automatic] synonym: "visceral nervous system ganglion" EXACT [OBOL:automatic] xref: AEO:0001001 xref: CALOHA:TS-2340 xref: EMAPA:18221 xref: FMA:5889 xref: MA:0000220 xref: MESH:D005725 xref: NCIT:C12720 xref: UMLS:C0017068 {source="ncithesaurus:Autonomic_Ganglion"} xref: Wikipedia:Autonomic_ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: extends_fibers_into UBERON:0034728 ! autonomic nerve relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0002410 ! autonomic nervous system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001806 name: sympathetic ganglion namespace: uberon def: "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." [http://orcid.org/0000-0002-6601-2165, MP:0001008] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "ganglion of sympathetic nervous system" EXACT [OBOL:automatic] synonym: "ganglion of sympathetic part of autonomic division of nervous system" EXACT [OBOL:automatic] synonym: "ganglion sympatheticum" EXACT [] synonym: "ganglion sympathicum" RELATED OMO:0003011 [BTO:0001333, Wikipedia:Sympathetic_ganglion] synonym: "sympathetic nervous system ganglion" EXACT [OBOL:automatic] synonym: "sympathetic part of autonomic division of nervous system ganglion" EXACT [OBOL:automatic] xref: AAO:0010773 xref: BTO:0001333 xref: CALOHA:TS-0994 xref: EHDAA2:0001969 xref: EMAPA:17157 xref: FMA:5890 xref: MA:0000226 xref: MESH:D005728 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C12467 xref: SCTID:362485003 xref: UMLS:C0017071 {source="ncithesaurus:Sympathetic_Ganglion"} xref: Wikipedia:Sympathetic_ganglion is_a: UBERON:0001805 ! autonomic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0000013 ! sympathetic nervous system relationship: contributes_to_morphology_of UBERON:0000013 ! sympathetic nervous system relationship: develops_from UBERON:0003083 {source="DOI:10.1101/gr.157586.113", source="ISBN:0073040584"} ! trunk neural crest relationship: extends_fibers_into UBERON:0034729 ! sympathetic nerve relationship: part_of UBERON:0000013 ! sympathetic nervous system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png xsd:anyURI [Term] id: UBERON:0001833 name: lip namespace: uberon def: "One of the two fleshy folds which surround the opening of the mouth." [http://www.medterms.com/script/main/art.asp?articlekey=9458, Wikipedia:Lip] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labia oris" RELATED OMO:0003011 [Wikipedia:Lip] synonym: "lips" RELATED [] xref: BTO:0001647 xref: CALOHA:TS-0558 xref: EMAPA:32839 xref: FMA:59816 xref: GAID:76 xref: galen:Lip xref: MA:0000343 xref: MESH:D008046 xref: NCIT:C12220 xref: SCTID:181221003 xref: TAO:0007006 xref: UMLS:C0023759 {source="ncithesaurus:Lip"} xref: VHOG:0000677 xref: Wikipedia:Lip xref: ZFA:0007006 is_a: UBERON:0003102 {source="ZFA"} ! surface structure relationship: contributes_to_morphology_of UBERON:0000165 ! mouth relationship: part_of UBERON:0000165 {source="BTO", source="FMA-implicit", source="VHOG", source="ZFA"} ! mouth relationship: part_of UBERON:0001456 ! face relationship: surrounds UBERON:0000166 {source="cjm"} ! oral opening property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg xsd:anyURI property_value: RO:0002161 NCBITaxon:8782 property_value: UBPROP:0000001 "Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007006", ontology="TAO", source="ZFIN:curator", source="http//:www.medterms.com/script/main/art.asp?articlekey=9458"} property_value: UBPROP:0000007 "labial" xsd:string [Term] id: UBERON:0001834 name: upper lip namespace: uberon alt_id: UBERON:0003391 def: "Lip that covers the upper portion of the mouth.[TAO]." [TAO:0001970, Wikipedia:Upper_lip] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labium superius oris" RELATED OMO:0003011 [Wikipedia:Upper_lip] synonym: "upper jaw lip" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:17925 xref: FMA:59817 xref: MA:0000919 xref: SCTID:245776003 xref: TAO:0001970 xref: VHOG:0001750 xref: Wikipedia:Upper_lip xref: ZFA:0005226 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: develops_from UBERON:0000033 ! head relationship: develops_from UBERON:0000062 ! organ relationship: develops_from UBERON:0000153 ! anterior region of body relationship: develops_from UBERON:0000165 ! mouth relationship: develops_from UBERON:0001007 ! digestive system relationship: develops_from UBERON:0001456 ! face relationship: develops_from UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0001709 ! upper jaw region relationship: develops_from UBERON:0004089 ! midface relationship: develops_from UBERON:0007811 ! craniocervical region relationship: develops_from UBERON:0011592 ! future upper lip relationship: develops_from UBERON:0011595 ! jaw region relationship: develops_from UBERON:0013701 ! main body axis relationship: develops_from UBERON:0013702 ! body proper relationship: immediate_transformation_of UBERON:0011592 ! future upper lip relationship: part_of UBERON:0001709 ! upper jaw region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg xsd:anyURI property_value: UBPROP:0000001 "Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001750", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Lip that covers the upper portion of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001970", ontology="TAO", source="TAO:wd"} [Term] id: UBERON:0001835 name: lower lip namespace: uberon alt_id: UBERON:0003392 def: "Lip that covers the lower portion of the mouth.[TAO]." [TAO:0002060, Wikipedia:Lower_lip] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labium inferius oris" RELATED OMO:0003011 [Wikipedia:Lower_lip] synonym: "lower jaw lip" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:17909 xref: FMA:59818 xref: MA:0000921 xref: NCIT:C94572 xref: SCTID:245777007 xref: TAO:0002060 xref: UMLS:C0458583 {source="ncithesaurus:Lower_Lip"} xref: Wikipedia:Lower_lip xref: ZFA:0005225 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: part_of UBERON:0001710 ! lower jaw region relationship: develops_from UBERON:0011596 ! future lower lip relationship: part_of UBERON:0001710 ! lower jaw region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg xsd:anyURI property_value: UBPROP:0000001 "Lip that covers the lower portion of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002060", ontology="TAO", source="TAO:wd"} [Term] id: UBERON:0001884 name: phrenic nerve namespace: uberon def: "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." [VHOG:0000728] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "diaphragmatic nerve" RELATED [BTO:0001063] synonym: "nervus phrenicus" RELATED OMO:0003011 [BTO:0001063, Wikipedia:Phrenic_nerve] synonym: "phrenic" RELATED [BTO:0001063] xref: BAMS:phn xref: BTO:0001063 xref: EHDAA:4677 xref: EMAPA:17813 xref: FMA:6191 xref: GAID:848 xref: MA:0001170 xref: MESH:D010791 xref: NCIT:C52813 xref: SCTID:280344009 xref: UMLS:C0031774 {source="ncithesaurus:Phrenic_Nerve"} xref: VHOG:0000728 xref: Wikipedia:Phrenic_nerve is_a: UBERON:0003443 ! thoracic cavity nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0001103 ! diaphragm relationship: branching_part_of UBERON:0000962 ! nerve of cervical vertebra relationship: innervates UBERON:0001103 ! diaphragm relationship: part_of UBERON:0000962 ! nerve of cervical vertebra property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000728", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/phrenic+nerve"} [Term] id: UBERON:0001891 name: midbrain namespace: uberon def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [GO:0030901] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "MB" BROAD OMO:0003000 [BIRNLEX:1667, NIFSTD:NeuroNames_abbrevSource] synonym: "mesencephalon" RELATED OMO:0003011 [Wikipedia:Midbrain] xref: AAO:0010149 xref: BAMS:MES xref: BIRNLEX:1667 xref: BM:MB xref: BTO:0000138 xref: CALOHA:TS-0630 xref: DHBA:10648 xref: DMBA:16649 xref: EFO:0000919 xref: EHDAA2:0001162 xref: EHDAA:3694 xref: EMAPA:16974 xref: EV:0100242 xref: FMA:61993 xref: HBA:9001 xref: MA:0000207 xref: MAT:0000106 xref: MBA:313 xref: MESH:D008636 xref: MIAA:0000106 xref: NCIT:C12510 xref: neuronames:462 {source="BIRNLEX:1667"} xref: RETIRED_EHDAA2:0001104 xref: SCTID:279099009 xref: TAO:0000128 xref: UMLS:C0025462 {source="BIRNLEX:1667", source="ncithesaurus:Mesencephalon"} xref: VHOG:0000069 xref: Wikipedia:Midbrain xref: XAO:0000014 xref: ZFA:0000128 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: contributes_to_morphology_of UBERON:0000955 ! brain relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0006238 ! future brain relationship: develops_from UBERON:0009616 ! presumptive midbrain relationship: has_developmental_contribution_from UBERON:0003849 {evidence="definitional"} ! mesencephalic neural crest relationship: immediate_transformation_of UBERON:0009616 {source="Bgee:AN"} ! presumptive midbrain property_value: editor_note "developmental relationships need revised" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG xsd:anyURI property_value: RO:0002171 UBERON:0001894 {exceptions="ZFA", exceptions_url="https://github.com/obophenotype/uberon/issues/378", source="ABA", status="pending"} property_value: RO:0002171 UBERON:0002028 {exceptions="ZFA", source="ABA", status="pending"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Middle part of the brain composed of the optic tectum and penducular region.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010149", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000128", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000069", ontology="VHOG", source="DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "mesencephalic" xsd:string property_value: UBPROP:0000012 "part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships" xsd:string {external_ontology="ABA"} [Term] id: UBERON:0001892 name: rhombomere namespace: uberon def: "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." [Wikipedia:Rhombomere, ZFIN:curator] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "future rhombencephalon" RELATED [MIAA:0000272] synonym: "hindbrain neuromere" EXACT [] synonym: "hindbrain neuromeres" EXACT OMO:0003004 [DHBA:HNM] synonym: "hindbrain segment" BROAD [ZFA:0001064] synonym: "rhombomere" EXACT [] synonym: "rhombomeres" RELATED OMO:0003004 [VHOG:0000672] synonym: "segment of hindbrain" BROAD [ZFA:0001064] xref: DHBA:12664 xref: EFO:0003617 xref: EMAPA:16148 xref: FMA:295666 xref: MAT:0000272 xref: MIAA:0000272 xref: RETIRED_EHDAA2:0000669 xref: TAO:0001064 xref: VHOG:0000672 xref: Wikipedia:Rhombomere xref: XAO:0004079 xref: ZFA:0001064 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: part_of UBERON:0007277 ! presumptive hindbrain relationship: part_of UBERON:0007277 ! presumptive hindbrain property_value: UBPROP:0000001 "A segment of the developing hindbrain. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001064", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000672", ontology="VHOG", source="DOI:10.1006/dbio.2002.0831 Mazet F, Shimeld SM, The Evolution of Chordate Neural Segmentation. Developmental Biology (2002)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In human embryonic development, the rhombomeres are present by day 29" xsd:string property_value: UBPROP:0000012 "DHBA divides this into A(1-3),B(4),C(5-7) and D(8)" xsd:string [Term] id: UBERON:0001895 name: metencephalon namespace: uberon def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Metencephalon] comment: the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "epencephalon" BROAD INCONSISTENT [ncithesaurus:Epencephalon] synonym: "epencephalon-2" EXACT [FMA:62003] xref: BAMS:Met xref: BIRNLEX:965 xref: BTO:0000673 xref: CALOHA:TS-2029 xref: DHBA:10655 xref: EHDAA2:0001149 xref: EHDAA:5498 xref: EMAPA:17071 xref: FMA:62003 xref: GAID:594 xref: HBA:4833 xref: MA:0000197 xref: MESH:D020540 xref: NCIT:C32741 xref: neuronames:543 {source="BIRNLEX:965"} xref: UMLS:C0376353 {source="BIRNLEX:965"} xref: UMLS:C1516904 {source="ncithesaurus:Epencephalon"} xref: VHOG:0000741 xref: Wikipedia:Metencephalon is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: contributes_to_morphology_of UBERON:0002028 ! hindbrain relationship: develops_from NCBITaxon:6072 ! Eumetazoa relationship: develops_from UBERON:0000955 ! brain relationship: develops_from UBERON:0001016 ! nervous system relationship: develops_from UBERON:0001017 ! central nervous system relationship: develops_from UBERON:0002028 ! hindbrain relationship: develops_from UBERON:0010092 ! future metencephalon relationship: immediate_transformation_of UBERON:0010092 {evidence="definitional"} ! future metencephalon property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg xsd:anyURI property_value: RO:0002174 NCBITaxon:7955 property_value: UBPROP:0000001 "Anterior part of the hindbrain ventral to the cerebellum[BIRNLEX:965]." xsd:string {source="BIRNLEX:965"} property_value: UBPROP:0000001 "The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000741", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/metencephalon"} property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000741", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001896 name: medulla oblongata namespace: uberon def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, Wikipedia:Bone_marrow_of_ovary_oblongata] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bulb" BROAD [] synonym: "bulbus" EXACT OMO:0003011 [FMA:62004, FMA:TA] synonym: "medulla" BROAD [ABA:MY] synonym: "medulla oblonzata" RELATED OMO:0003011 [Wikipedia:Medulla_oblongata] synonym: "metepencephalon" RELATED [FMA:62004] xref: AAO:0010486 xref: BAMS:Md xref: BAMS:MY xref: BIRNLEX:957 xref: BM:Me xref: BTO:0000041 xref: CALOHA:TS-0607 xref: DMBA:17352 xref: EFO:0000924 xref: EHDAA2:0001088 xref: EHDAA:7588 xref: EMAPA:17550 xref: EV:0100275 xref: FMA:62004 xref: GAID:590 xref: MA:0000206 xref: MAT:0000111 xref: MAT:0000367 xref: MBA:354 xref: MESH:D008526 xref: MIAA:0000111 xref: NCIT:C12442 xref: neuronames:698 {source="BIRNLEX:957"} xref: SCTID:279104005 xref: TAO:0000545 xref: UMLS:C0025148 {source="ncithesaurus:Medulla_Oblongata", source="BIRNLEX:957"} xref: UMLS:C1269575 {source="BIRNLEX:957"} xref: VHOG:0000181 xref: Wikipedia:Bone_marrow_of_ovary_oblongata xref: XAO:0003100 xref: ZFA:0000545 is_a: UBERON:0000064 ! organ part relationship: capable_of GO:0002027 ! regulation of heart rate relationship: capable_of GO:0043576 ! regulation of respiratory gaseous exchange relationship: capable_of GO:0044058 ! regulation of digestive system process relationship: part_of UBERON:0002298 ! brainstem relationship: part_of UBERON:0005290 ! myelencephalon property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010486", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001901 name: epithelium of trachea namespace: uberon alt_id: UBERON:0003227 def: "The epithelial lining of the trachea which contains numerous ciliated cells." [ISBN:0-397-51047-0, MGI:cwg, MP:0002285] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "epithelial tissue of trachea" EXACT [OBOL:automatic] synonym: "epithelial tissue of windpipe" EXACT [OBOL:automatic] synonym: "epithelium of windpipe" EXACT [OBOL:automatic] synonym: "trachea epithelial tissue" EXACT [OBOL:automatic] synonym: "trachea epithelium" EXACT [] synonym: "tracheal epithelium" EXACT [] synonym: "windpipe epithelial tissue" EXACT [OBOL:automatic] synonym: "windpipe epithelium" EXACT [OBOL:automatic] xref: BTO:0001389 xref: CALOHA:TS-1061 xref: EHDAA2:0002069 xref: EHDAA:5007 xref: EMAPA:16855 xref: EMAPA:18409 xref: FMA:62015 xref: MA:0001862 xref: NCIT:C33797 xref: UMLS:C1179002 {source="ncithesaurus:Tracheal_Epithelium"} xref: VHOG:0001045 is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003126 ! trachea relationship: contributes_to_morphology_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0003258 ! endoderm of foregut relationship: part_of UBERON:0003126 ! trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001902 name: epithelium of small intestine namespace: uberon def: "An epithelium that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "epithelial tissue of small bowel" EXACT [OBOL:automatic] synonym: "epithelial tissue of small intestine" EXACT [OBOL:automatic] synonym: "epithelium of small bowel" EXACT [OBOL:automatic] synonym: "mid intestine epithelium" EXACT [ZFA:0005127] synonym: "small bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "small bowel epithelium" EXACT [OBOL:automatic] synonym: "small intestinal epithelium" EXACT [] synonym: "small intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "small intestine epithelium" EXACT [] xref: BTO:0001258 xref: CALOHA:TS-2104 xref: EMAPA:35778 xref: FMA:62017 xref: MA:0001553 xref: SCTID:45480009 xref: TAO:0005127 xref: ZFA:0005127 is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002108 ! small intestine relationship: has_part CL:0000164 {source="FMA"} ! enteroendocrine cell relationship: part_of UBERON:0001204 ! mucosa of small intestine property_value: UBPROP:0000001 "Intestinal epithelium which lines the lumen of the mid intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005127", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001915 name: endothelium of capillary namespace: uberon def: "An endothelium that is part of a capillary [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood capillary endothelium" EXACT [OBOL:automatic] synonym: "capillary endothelium" EXACT [] synonym: "capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel" EXACT [OBOL:automatic] xref: BTO:0004954 xref: CALOHA:TS-0112 xref: EMAPA:36292 xref: FMA:62114 xref: MA:0000711 xref: NCIT:C49215 xref: UMLS:C0006904 {source="ncithesaurus:Capillary_Endothelium"} is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001982 ! capillary relationship: part_of UBERON:0001982 ! capillary [Term] id: UBERON:0001916 name: endothelium of arteriole namespace: uberon def: "An endothelium that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arteriole endothelium" EXACT [] xref: EMAPA:36286 xref: FMA:62115 xref: MA:0000705 xref: NCIT:C49192 xref: UMLS:C1179024 {source="ncithesaurus:Arteriole_Endothelium"} is_a: UBERON:0004700 ! arterial system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: UBERON:0001917 name: endothelium of artery namespace: uberon def: "An endothelium that is part of an artery [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arterial endothelium" EXACT [] synonym: "artery endothelium" EXACT [] xref: AAO:0011013 xref: BTO:0004757 xref: EMAPA:35148 xref: FMA:62116 xref: MA:0000707 xref: NCIT:C49194 xref: UMLS:C1179025 {source="ncithesaurus:Artery_Endothelium"} xref: VHOG:0001215 xref: XAO:0000357 is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery property_value: UBPROP:0000001 "The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011013", ontology="AAO", source="XAO:curator"} property_value: UBPROP:0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001215", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001918 name: endothelium of venule namespace: uberon def: "An endothelium that is part of a venule [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "venule endothelium" EXACT [] xref: EMAPA:36290 xref: FMA:62117 xref: MA:0000716 xref: NCIT:C49319 xref: UMLS:C1179026 {source="ncithesaurus:Venule_Endothelium"} is_a: UBERON:0004701 ! venous system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule [Term] id: UBERON:0001919 name: endothelium of vein namespace: uberon def: "An endothelium that is part of a vein [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "vein endothelium" EXACT [] synonym: "veinous endothelium" RELATED [VHOG:0001216] synonym: "venous endothelium" EXACT [] xref: AAO:0011110 xref: BTO:0004756 xref: EMAPA:36288 xref: FMA:62118 xref: MA:0000712 xref: NCIT:C49317 xref: UMLS:C1179027 {source="ncithesaurus:Vein_Endothelium"} xref: VHOG:0001216 xref: XAO:0000358 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein property_value: UBPROP:0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001216", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001943 name: midbrain tegmentum namespace: uberon def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [FMA:FMA, ISBN:0471888893, Wikipedia:Midbrain_tegmentum] comment: 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mesencephalic tegmentum" RELATED [VHOG:0001367] synonym: "MTg" BROAD OMO:0003000 [BIRNLEX:1200, NIFSTD:NeuroNames_abbrevSource] synonym: "tegmentum" BROAD [ISBN:0471888893] synonym: "tegmentum mesencephali" EXACT OMO:0003011 [Wikipedia:Midbrain_tegmentum] synonym: "tegmentum mesencephalicum" RELATED OMO:0003011 [NeuroNames:491] synonym: "tegmentum of midbrain" EXACT [] xref: BAMS:MTg xref: BIRNLEX:1200 xref: BTO:0003388 xref: DHBA:12195 xref: EFO:0000921 xref: EHDAA2:0004475 xref: EMAPA:18215 xref: FMA:62393 xref: HBA:9002 xref: MA:0000212 xref: MAT:0000452 xref: MESH:D013681 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:491 {source="BIRNLEX:1200"} xref: SCTID:362392007 xref: TAO:0000160 xref: UMLS:C0039441 {source="BIRNLEX:1200"} xref: VHOG:0001367 xref: Wikipedia:Midbrain_tegmentum xref: XAO:0004271 xref: ZFA:0000160 is_a: UBERON:0002616 ! regional part of brain relationship: develops_from UBERON:0010285 {source="ZFA"} ! midbrain basal plate relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0002298 ! brainstem property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0001948 name: regional part of spinal cord namespace: uberon def: "A multi-tissue structure that is part of a spinal cord." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: non_informative synonym: "spinal cord part" RELATED [] xref: BIRNLEX:1496 xref: NCIT:C33969 xref: SCTID:244437008 xref: UMLS:C1268166 {source="ncithesaurus:Spinal_Cord_Part"} is_a: UBERON:0000073 ! regional part of nervous system intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0001956 name: cartilage of bronchus namespace: uberon def: "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." [MP:0010988] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bronchi cartilage" EXACT [OBOL:automatic] synonym: "bronchial cartilage" EXACT [] synonym: "bronchial cartilage ring" EXACT [MP:0010988] synonym: "bronchial trunk cartilage" EXACT [OBOL:automatic] synonym: "bronchus cartilage" EXACT [] synonym: "cartilage of bronchi" EXACT [OBOL:automatic] synonym: "cartilage of bronchial trunk" EXACT [OBOL:automatic] synonym: "cartilagines bronchiales" EXACT OMO:0003004 [] xref: EMAPA:35192 xref: FMA:62649 xref: MA:0001835 xref: NCIT:C49209 xref: SCTID:278980009 xref: UMLS:C0225604 {source="ncithesaurus:Bronchus_Cartilage"} is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0002185 ! bronchus relationship: composed_primarily_of UBERON:0001994 {source="MP"} ! hyaline cartilage tissue relationship: contributes_to_morphology_of UBERON:0002185 ! bronchus relationship: has_part CL:0019002 ! tracheobronchial chondrocyte relationship: part_of UBERON:0002185 ! bronchus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001957 name: submucosa of bronchus namespace: uberon def: "A submucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bronchi submucosa" EXACT [OBOL:automatic] synonym: "bronchial submucosa" EXACT [] synonym: "bronchial trunk submucosa" EXACT [OBOL:automatic] synonym: "bronchus submucosa" EXACT [] synonym: "submucosa of bronchi" EXACT [OBOL:automatic] synonym: "submucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "submucous layer of bronchi" RELATED [BTO:0002108] synonym: "tela submucosa bronchi" EXACT OMO:0003011 [FMA:62653, FMA:TA] xref: BTO:0002108 xref: EMAPA:37449 {source="MA:th"} xref: FMA:62653 xref: MA:0001837 xref: NCIT:C49214 xref: SCTID:85546005 xref: UMLS:C0225601 {source="ncithesaurus:Bronchus_Submucosa"} is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0001969 name: blood plasma namespace: uberon def: "The liquid component of blood, in which erythrocytes are suspended." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "blood plasm" EXACT [] synonym: "plasma" BROAD [MA:0002501] synonym: "portion of blood plasma" EXACT [] synonym: "portion of plasma" BROAD [FMA:62970] xref: BTO:0000131 xref: CALOHA:TS-0800 xref: EFO:0001905 xref: EMAPA:35690 xref: FMA:62970 xref: GAID:1178 xref: MA:0002501 xref: MAT:0000052 xref: MESH:D010949 xref: MIAA:0000052 xref: NCIT:C13356 xref: UMLS:C0032105 {source="ncithesaurus:Plasma"} xref: Wikipedia:Blood_plasma is_a: UBERON:0000179 ! haemolymphatic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: has_part GO:0005577 ! fibrinogen complex intersection_of: has_quality PATO:0001548 ! quality of a liquid intersection_of: part_of UBERON:0000178 ! blood intersection_of: surrounds CL:0000232 ! erythrocyte relationship: has_part GO:0005577 ! fibrinogen complex relationship: part_of UBERON:0000178 ! blood relationship: surrounds CL:0000232 ! erythrocyte [Term] id: UBERON:0001970 name: bile namespace: uberon def: "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." [DOI:10.1002/cphy.c120027, Wikipedia:Bile] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "fel" RELATED [BTO:0000121] synonym: "gall" RELATED [BTO:0000121] xref: BTO:0000121 xref: CALOHA:TS-1172 xref: ENVO:02000023 xref: FMA:62971 xref: GAID:1157 xref: galen:Bile xref: MA:0002513 xref: MESH:D001646 xref: NCIT:C13192 xref: UMLS:C0005388 {source="ncithesaurus:Bile"} xref: Wikipedia:Bile xref: ZFA:0005857 is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: produced_by UBERON:0002107 ! liver relationship: capable_of_part_of GO:0007586 ! digestion relationship: has_part CHEBI:16990 {composition="0.3% in humans"} ! bilirubin IXalpha relationship: has_part CHEBI:22868 ! bile salt relationship: has_part CHEBI:36277 ! bile acid salt relationship: has_quality PATO:0001735 ! liquid configuration relationship: produced_by UBERON:0002107 ! liver property_value: UBPROP:0000008 "In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum." xsd:string property_value: UBPROP:0000009 "aids the process of digestion of lipids in the small intestine" xsd:string property_value: UBPROP:0000009 "bile salts function to emulsify dietary fats and facilitate their intestinal absorption" xsd:string property_value: UBPROP:0000009 "elimination of cholesterol" xsd:string property_value: UBPROP:0000009 "major excretory route for potentially harmful exogenous lipophilic substances" xsd:string property_value: UBPROP:0000009 "many hormones and pheromones are excreted in bile, and contribute to growth and development of the intestine in some species and provide attractants for the weaning of non-human vertebrates" xsd:string property_value: UBPROP:0000009 "protects the organism from enteric infections by excreting immune globulin A (IgA), inflammatory cytokines, and stimulating the innate immune system in the intestine" xsd:string [Term] id: UBERON:0001971 name: gastric juice namespace: uberon subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "stomach secretion" EXACT [] synonym: "succus gastricus" RELATED [BTO:0000501] xref: BTO:0000501 xref: FMA:62972 xref: GAID:1160 xref: galen:GastricJuice xref: MA:0002519 xref: MESH:D005750 xref: NCIT:C32661 xref: UMLS:C0017133 {source="ncithesaurus:Gastric_Secretion"} xref: Wikipedia:Gastric_juice is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: produced_by UBERON:0011953 ! stomach glandular region relationship: produced_by UBERON:0011953 ! stomach glandular region [Term] id: UBERON:0001972 name: submucosa of esophagus namespace: uberon def: "A submucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "esophageal submucosa" EXACT [] synonym: "esophagus submucosa" EXACT [] synonym: "gullet submucosa" EXACT [OBOL:automatic] synonym: "oesophagus submucosa" EXACT [OBOL:automatic] synonym: "submucosa of esophagus" EXACT [] synonym: "submucosa of gullet" EXACT [OBOL:automatic] synonym: "submucosa of oesophagus" EXACT [OBOL:automatic] synonym: "submucous layer of esophagus" RELATED [BTO:0002109] synonym: "tela submucosa (oesophagus)" EXACT OMO:0003011 [FMA:62997, FMA:TA] synonym: "tela submucosa esophagi" EXACT OMO:0003011 [BTO:0002109] synonym: "tela submucosa oesophageae" EXACT OMO:0003011 [FMA:62997, FMA:TA] synonym: "tela submucosa oesophagi" RELATED [BTO:0002109] synonym: "tela submucosa of esophagus" EXACT [] xref: BTO:0002109 xref: EMAPA:35325 xref: FMA:62997 xref: MA:0002724 xref: SCTID:362128009 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0001974 name: lamina propria of esophagus namespace: uberon def: "A lamina propria that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "esophageal lamina propria" RELATED [EMAPA:26987] synonym: "esophagus lamina propria" EXACT [] synonym: "esophagus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "esophagus lamina propria mucosae" EXACT [OBOL:automatic] synonym: "gullet lamina propria" EXACT [OBOL:automatic] synonym: "gullet lamina propria mucosa" EXACT [OBOL:automatic] synonym: "gullet lamina propria mucosae" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of esophagus" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of gullet" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of oesophagus" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of esophagus" EXACT [] synonym: "lamina propria mucosae of gullet" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of oesophagus" EXACT [OBOL:automatic] synonym: "lamina propria of gullet" EXACT [OBOL:automatic] synonym: "lamina propria of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus lamina propria" RELATED [] synonym: "oesophagus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "oesophagus lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:26987 xref: FMA:63050 xref: MA:0001568 xref: NCIT:C49223 xref: UMLS:C1707949 {source="ncithesaurus:Esophageal_Lamina_Propria"} is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0002469 {source="FMA"} ! esophagus mucosa [Term] id: UBERON:0001975 name: serosa of esophagus namespace: uberon def: "A serous membrane that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "esophagus serosa" EXACT [] synonym: "esophagus serous membrane" EXACT [OBOL:automatic] synonym: "gullet serosa" EXACT [OBOL:automatic] synonym: "gullet serous membrane" EXACT [OBOL:automatic] synonym: "oesophagus serosa" RELATED [] synonym: "oesophagus serous membrane" EXACT [OBOL:automatic] synonym: "serosa of abdominal part of esophagus" EXACT [] synonym: "serosa of gullet" EXACT [OBOL:automatic] synonym: "serosa of oesophagus" EXACT [] synonym: "serous coat of oesophagus" EXACT [] synonym: "serous membrane of esophagus" EXACT [OBOL:automatic] synonym: "serous membrane of gullet" EXACT [OBOL:automatic] synonym: "serous membrane of oesophagus" EXACT [OBOL:automatic] synonym: "tunica serosa oesophageae" EXACT OMO:0003011 [FMA:63057, FMA:TA] xref: EMAPA:35322 xref: FMA:63057 xref: MA:0001571 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0001976 name: epithelium of esophagus namespace: uberon def: "The epithelial layer that lines the luminal space of the esophagus." [ISBN:0-683-40008-8, MP:0000468] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithelial tissue of esophagus" EXACT [OBOL:automatic] synonym: "epithelial tissue of gullet" EXACT [OBOL:automatic] synonym: "epithelial tissue of oesophagus" EXACT [OBOL:automatic] synonym: "epithelium of gullet" EXACT [OBOL:automatic] synonym: "epithelium of oesophagus" EXACT [OBOL:automatic] synonym: "esophageal epithelium" EXACT [] synonym: "esophagus epithelial tissue" EXACT [OBOL:automatic] synonym: "esophagus epithelium" EXACT [] synonym: "gullet epithelial tissue" EXACT [OBOL:automatic] synonym: "gullet epithelium" EXACT [OBOL:automatic] synonym: "oesophagus epithelial tissue" EXACT [OBOL:automatic] synonym: "oesophagus epithelium" RELATED [] xref: BTO:0001578 xref: CALOHA:TS-0698 xref: EFO:0003041 xref: EHDAA2:0001287 xref: EMAPA:16835 xref: FMA:63063 xref: MA:0001565 xref: NCIT:C49221 xref: TAO:0001499 xref: UMLS:C1179544 {source="ncithesaurus:Esophageal_Epithelium"} xref: ZFA:0001499 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001043 ! esophagus relationship: contributes_to_morphology_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0002469 {source="FMA"} ! esophagus mucosa property_value: editor_note "TODO check epithelium types: in FMA: Nonkeratinizing stratified squamous epithelium; mouse has basal and squamous subtypes; in ZFA it is columnar" xsd:string property_value: UBPROP:0000001 "Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001499", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001978 name: parenchyma of pancreas namespace: uberon subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pancreas parenchyma" EXACT [] synonym: "pancreatic parenchyma" EXACT [] xref: EMAPA:32925 xref: FMA:63120 xref: MA:0000724 xref: SCTID:371401008 xref: VHOG:0001430 is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001979 name: venule namespace: uberon def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." [MESH:A07.231.432.952, MP:0004125] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "venula" RELATED OMO:0003011 [Wikipedia:Venule] xref: BTO:0002626 xref: EMAPA:35917 xref: FMA:63130 xref: MA:0000071 xref: MESH:D014699 xref: NCIT:C12818 xref: SCTID:341687009 xref: TAO:0005315 xref: UMLS:C0042520 {source="ncithesaurus:Venule"} xref: VHOG:0001765 xref: Wikipedia:Venule xref: ZFA:0005315 is_a: UBERON:0003920 ! venous blood vessel is_a: UBERON:8410081 ! blood microvessel relationship: connects UBERON:0001638 ! vein relationship: connects UBERON:0001982 ! capillary property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005315", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001980 name: arteriole namespace: uberon def: "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." [GO:0014830] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteriola" RELATED OMO:0003011 [Wikipedia:Arteriole] xref: AAO:0010253 xref: BTO:0001997 xref: EMAPA:35146 xref: FMA:63182 xref: MA:0000063 xref: MESH:D001160 xref: NCIT:C12672 xref: SCTID:337724002 xref: TAO:0002138 xref: UMLS:C0003847 {source="ncithesaurus:Arteriole"} xref: VHOG:0001763 xref: Wikipedia:Arteriole xref: ZFA:0005255 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: connects UBERON:0001637 ! artery intersection_of: connects UBERON:0001982 ! capillary relationship: connects UBERON:0001637 ! artery relationship: connects UBERON:0001982 ! capillary relationship: contributes_to_morphology_of UBERON:0001637 ! artery property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg xsd:anyURI property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002138", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Small, terminal branch of an artery which generally connects to capillaries.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010253", ontology="AAO", source="AAO:BJB"} [Term] id: UBERON:0001981 name: blood vessel namespace: uberon def: "A vessel through which blood circulates in the body." [BTO:0001102, Wikipedia:Blood_vessel] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "region of vascular tree organ" EXACT [FMA:50722] synonym: "vas sanguineum" RELATED OMO:0003011 [Wikipedia:Blood_vessel] synonym: "vascular element" BROAD [EMAPA:35993] synonym: "vascular tree organ region" EXACT [FMA:50722] xref: AAO:0011004 xref: AEO:0000207 xref: BTO:0001102 xref: CALOHA:TS-0080 xref: EFO:0000817 xref: EHDAA2:0003252 xref: EHDAA:240 xref: EMAPA:32743 xref: EMAPA:35993 xref: FMA:50722 xref: FMA:63183 xref: GAID:169 xref: MA:0000060 xref: MAT:0000393 xref: MESH:D001808 xref: NCIT:C12679 xref: NLXANAT:090901 xref: SCTID:361097006 xref: TAO:0002137 xref: UMLS:C0005847 {source="ncithesaurus:Blood_Vessel"} xref: VHOG:0001250 xref: Wikipedia:Blood_vessel xref: XAO:0001011 xref: ZFA:0005314 is_a: UBERON:0000055 ! vessel relationship: capable_of_part_of GO:0008015 ! blood circulation relationship: channel_for UBERON:0000178 ! blood relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: develops_from UBERON:0006965 {source="GO:0072360"} ! vascular cord relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends relationship: has_quality PATO:0002045 ! dendritic relationship: part_of UBERON:0004537 ! blood vasculature property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "annelids have blood vessels, but this class is not applicable to annelids." xsd:string property_value: UBPROP:0000012 "FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001982 name: capillary namespace: uberon def: "Any of the smallest blood vessels connecting arterioles with venules." [https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584, Wikipedia:Capillary] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blood capillary" EXACT [] synonym: "capillary vessel" EXACT [] xref: AAO:0010252 xref: BTO:0002045 xref: CALOHA:TS-2006 xref: EFO:0001906 xref: EMAPA:35198 xref: EV:0100035 xref: FMA:63194 xref: MA:0000065 xref: MESH:D002196 xref: NCIT:C12685 xref: NLXANAT:090902 xref: TAO:0005250 xref: UMLS:C0935624 {source="ncithesaurus:Capillary"} xref: VHOG:0001253 xref: Wikipedia:Capillary xref: XAO:0000116 xref: ZFA:0005250 is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:8410081 ! blood microvessel intersection_of: connects UBERON:0001979 ! venule intersection_of: connects UBERON:0001980 ! arteriole relationship: connects UBERON:0001979 ! venule relationship: connects UBERON:0001980 ! arteriole property_value: editor_note "not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/2186 xsd:string property_value: UBPROP:0000001 "Any of the tiny blood vessels connecting the arterioles to the venules.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010252", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001253", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000010 "capillaries lack tunica media and tunica adventitia; only the endothelial wall of the tunica intima belongs" xsd:string [Term] id: UBERON:0001983 name: crypt of Lieberkuhn namespace: uberon def: "The tubular intestinal glands found in the mucosal membranes." [https://github.com/obophenotype/uberon/issues/213, ISBN:0-683-40008-8, MP:0000490] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "crypt of Lieberkuhn" EXACT [] synonym: "crypt of Lieberkühn" EXACT [] synonym: "crypts of Lieberkühn" EXACT OMO:0003004 [] synonym: "follicles of Lieberkühn" EXACT [] synonym: "intestinal crypt" EXACT [] synonym: "intestinal crypts" EXACT OMO:0003004 [] synonym: "intestinal gland" BROAD [Wikipedia:Crypts_of_Lieberkuhn] synonym: "intestinal gland of Lieberkuhn" RELATED [FMA:63621] synonym: "Lieberkuhn crypt" EXACT [] synonym: "Lieberkuhn gland" EXACT [] synonym: "Lieberkuhn's gland" EXACT [] synonym: "Lieberkuhn's glands" EXACT OMO:0003004 [] synonym: "Lieberkühn crypt" EXACT [] xref: EMAPA:35266 xref: FMA:63621 xref: MA:0001535 xref: NCIT:C32411 xref: SCTID:118652008 xref: UMLS:C1621887 {source="ncithesaurus:Crypts_of_the_Lieberkuhn"} xref: Wikipedia:Intestinal_crypt is_a: UBERON:0000333 ! intestinal gland relationship: contributes_to_morphology_of UBERON:0001242 ! intestinal mucosa relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular relationship: in_taxon NCBITaxon:32523 {notes="further investigation required", source="ISBN:9780521617147"} ! Tetrapoda relationship: seeAlso UBERON:2005256 property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg xsd:anyURI property_value: UBPROP:0000001 "In histology, an intestinal crypt, also crypt of LieberkC property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "endothelial" xsd:string [Term] id: UBERON:0001988 name: feces namespace: uberon def: "Portion of semisolid bodily waste discharged through the anus[MW,modified]." [http://www.merriam-webster.com/dictionary/feces, Wikipedia:Feces] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cow dung" NARROW [Wikipedia:Cow_dung] synonym: "cow pat" NARROW [Wikipedia:Cow_dung] synonym: "droppings" RELATED [] synonym: "dung" NARROW [] synonym: "excrement" RELATED [BTO:0000440] synonym: "excreta" BROAD [] synonym: "faeces" EXACT [] synonym: "fecal material" EXACT [] synonym: "fecal matter" EXACT [] synonym: "fewmet" NARROW [Wikipedia:Fewmet] synonym: "frass" NARROW [Wikipedia:Frass] synonym: "guano" NARROW [Wikipedia:Guano] synonym: "ordure" RELATED [] synonym: "piece of shit" EXACT [PMID:23285307] synonym: "portion of dung" NARROW [] synonym: "portion of excrement" EXACT [] synonym: "portion of faeces" EXACT [] synonym: "portion of fecal material" EXACT [] synonym: "portion of fecal matter" EXACT [] synonym: "portion of feces" EXACT [] synonym: "portion of guano" NARROW [] synonym: "portion of scat" NARROW [] synonym: "portionem cacas" EXACT OMO:0003011 [] synonym: "scat" NARROW [] synonym: "spoor" RELATED [] synonym: "spraint" NARROW [Wikipedia:Spraint] synonym: "stool" EXACT [] xref: BTO:0000440 xref: CALOHA:TS-2345 xref: ENVO:00002003 xref: FMA:64183 xref: GAID:1199 xref: galen:Feces xref: MA:0002509 xref: MAT:0000053 xref: MESH:D005243 xref: MIAA:0000053 xref: NCIT:C13234 xref: UMLS:C0015733 {source="ncithesaurus:Feces"} xref: Wikipedia:Feces is_a: UBERON:0000174 ! excreta intersection_of: UBERON:0000174 ! excreta intersection_of: output_of GO:0030421 ! defecation relationship: output_of GO:0030421 ! defecation property_value: UBPROP:0000001 "Excretion in semisolid state processed by the intestine.[FMA]" xsd:string {source="FMA:64183"} property_value: UBPROP:0000007 "fecal" xsd:string [Term] id: UBERON:0001994 name: hyaline cartilage tissue namespace: uberon def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000094] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "chondroid cartilage" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "hyaline cartilage" EXACT [MA:0000109] xref: EMAPA:35414 xref: FMA:64783 xref: MA:0000109 xref: NCIT:C32746 xref: SCTID:39298000 xref: UMLS:C0225362 {source="ncithesaurus:Hyaline_Cartilage"} xref: VSAO:0000094 xref: Wikipedia:Hyaline_cartilage xref: XAO:0004029 is_a: UBERON:0002418 {source="FMA"} ! cartilage tissue relationship: composed_primarily_of GO:0005585 {source="VSAO-text-def"} ! collagen type II trimer property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray292.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg xsd:anyURI property_value: UBPROP:0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783]." xsd:string {source="FMA:64783"} property_value: UBPROP:0000001 "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000094", ontology="VSAO", source="PSPUB:0000170"} [Term] id: UBERON:0002012 name: pulmonary artery namespace: uberon def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pulmonary_artery] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "arteria pulmonalis" RELATED OMO:0003011 [Wikipedia:Pulmonary_artery] synonym: "pulmonary arterial subtree" RELATED [FMA:66326] synonym: "pulmonary arterial tree" EXACT [FMA:66326] synonym: "pulmonary arterial tree organ part" EXACT [FMA:66326] synonym: "truncus pulmonalis" RELATED OMO:0003011 [Wikipedia:Pulmonary_artery] xref: AAO:0010221 xref: BTO:0000778 xref: CALOHA:TS-0839 xref: EFO:0001399 xref: EHDAA2:0001575 xref: EHDAA:4351 xref: EMAPA:17008 xref: FMA:66326 xref: GAID:505 xref: galen:PulmonaryArtery xref: MA:0002031 xref: MESH:D011651 xref: NCIT:C12774 xref: SCTID:181380003 xref: UMLS:C0034052 {source="ncithesaurus:Pulmonary_Artery"} xref: VHOG:0000982 xref: Wikipedia:Pulmonary_artery xref: XAO:0004162 is_a: UBERON:0001637 ! artery is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0008886 ! pulmonary vascular system intersection_of: vessel_supplies_blood_to UBERON:0002048 ! lung disjoint_from: UBERON:0004573 ! systemic artery relationship: continuous_with UBERON:0002333 ! pulmonary trunk relationship: develops_from UBERON:0002061 {source="Wikipedia"} ! truncus arteriosus relationship: develops_from UBERON:0003123 {source="EHDAA2", source="XAO"} ! pharyngeal arch artery 6 relationship: develops_from UBERON:0005339 {source="EHDAA2"} ! outflow tract pulmonary component relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0008886 ! pulmonary vascular system relationship: vessel_supplies_blood_to UBERON:0002048 ! lung property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Major artery which supplies blood to the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010221", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000982", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+artery"} property_value: UBPROP:0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000982", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung[WP]" xsd:string [Term] id: UBERON:0002016 name: pulmonary vein namespace: uberon def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." [GO:0060577] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pulmonary venous tree organ part" EXACT [] synonym: "venae pulmonales" RELATED OMO:0003011 [Wikipedia:Pulmonary_vein] xref: AAO:0010521 xref: BTO:0001799 xref: CALOHA:TS-0840 xref: EHDAA2:0001579 xref: EHDAA:2629 xref: EMAPA:18645 xref: FMA:66643 xref: GAID:543 xref: galen:PulmonaryVein xref: MA:0002206 xref: MESH:D011667 xref: NCIT:C12776 xref: SCTID:430160002 xref: UMLS:C0034090 {source="ncithesaurus:Pulmonary_Vein"} xref: VHOG:0001133 xref: Wikipedia:Pulmonary_vein xref: XAO:0000394 is_a: UBERON:0001638 ! vein is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0002048 ! lung relationship: connected_to UBERON:0002079 ! left cardiac atrium relationship: develops_from UBERON:0002061 ! truncus arteriosus relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0008886 ! pulmonary vascular system relationship: vessel_drains_blood_from UBERON:0002048 ! lung property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010521", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001133", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+vein"} property_value: UBPROP:0000001 "the veins that return oxygenated blood from the lungs to the left atrium of the heart" xsd:string {source="MP:0002726,MGI:cwg"} property_value: UBPROP:0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001133", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000202 FMA:70827 [Term] id: UBERON:0002017 name: portal vein namespace: uberon def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." [BTO:0001792] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "portal venous tree organ part" EXACT [FMA:66645] xref: BTO:0001792 xref: CALOHA:TS-0814 xref: EHDAA2:0001485 xref: EHDAA:6510 xref: EMAPA:17349 xref: FMA:66645 xref: GAID:540 xref: galen:PortalVein xref: MA:0002198 xref: MESH:D011169 xref: NCIT:C33343 xref: SCTID:362064007 xref: UMLS:C0032718 {source="ncithesaurus:Portal_Vein"} xref: VHOG:0000656 xref: XAO:0000392 is_a: UBERON:0001638 {source="FMA"} ! vein relationship: part_of UBERON:0005806 ! portal system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI [Term] id: UBERON:0002020 name: gray matter namespace: uberon def: "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Gray_matter] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gray mater" RELATED [ZFA:0001681] synonym: "gray matter" EXACT [] synonym: "gray matter of neuraxis" EXACT [FMA:67242] synonym: "grey matter" EXACT [] synonym: "grey matter of neuraxis" EXACT [] synonym: "grey substance" EXACT [] synonym: "grisea" RELATED OMO:0003011 [] synonym: "neuronal grey matter" EXACT [AEO:0001012] synonym: "substantia grisea" EXACT OMO:0003011 [FMA:67242, FMA:TA] xref: AEO:0001012 xref: EHDAA2:0003136 xref: EHDAA2_RETIRED:0004658 xref: EMAPA:37596 {source="MA:th"} xref: FMA:67242 xref: HBA:4006 xref: MA:0001112 xref: MESH:D066128 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C32695 xref: neuronames:2869 xref: TAO:0002197 xref: UMLS:C0018220 {source="ncithesaurus:Gray_Matter"} xref: VHOG:0001768 xref: Wikipedia:Gray_matter xref: ZFA:0001681 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: composed_primarily_of GO:0043025 ! neuronal cell body property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: UBPROP:0000001 "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002197", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0002028 name: hindbrain namespace: uberon def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [Wikipedia:Rhombencephalon, ZFA:0000029, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "rhombencephalon" RELATED [] xref: AAO:0010150 xref: BAMS:HB xref: BIRNLEX:942 xref: BTO:0000672 xref: CALOHA:TS-0457 xref: DHBA:10653 xref: DMBA:16808 xref: EFO:0000923 xref: EHDAA2:0000746 xref: EHDAA:3514 xref: EHDAA:6487 xref: EMAPA:16916 xref: FMA:67687 xref: MA:0000195 xref: MAT:0000107 xref: MBA:1065 xref: MESH:D012249 xref: MIAA:0000107 xref: NCIT:C40336 xref: neuronames:540 {source="BIRNLEX:942"} xref: SCTID:303456008 xref: TAO:0000029 xref: UMLS:C0035507 {source="ncithesaurus:Hind-Brain", source="BIRNLEX:942"} xref: UMLS:C1522180 {source="BIRNLEX:942"} xref: VHOG:0000070 xref: Wikipedia:Rhombencephalon xref: XAO:0000015 xref: ZFA:0000029 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0000955 ! brain relationship: develops_from UBERON:0002346 ! neurectoderm relationship: develops_from UBERON:0006238 ! future brain relationship: develops_from UBERON:0007277 ! presumptive hindbrain relationship: immediate_transformation_of UBERON:0007277 {source="Bgee:AN"} ! presumptive hindbrain relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: overlaps UBERON:0002298 {notes="modified-source-relation", source="ABA"} ! brainstem property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg xsd:anyURI property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} property_value: RO:0002171 UBERON:0001894 {source="ABA"} property_value: RO:0002175 NCBITaxon:7762 {source="PMID:8932866"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010150", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000029", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000029", ontology="TAO"} property_value: UBPROP:0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000070", ontology="VHOG", source="DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "rhombencephalic" xsd:string property_value: UBPROP:0000012 "in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps" xsd:string {external_ontology="MA"} [Term] id: UBERON:0002029 name: epithelium of gall bladder namespace: uberon def: "The simple columnar epithelial lining of the gall bladder." [MP:0009492] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "biliary epithelium" RELATED [] synonym: "epithelial tissue of gall bladder" EXACT [OBOL:automatic] synonym: "epithelial tissue of gallbladder" EXACT [OBOL:automatic] synonym: "epithelium of gallbladder" EXACT [OBOL:automatic] synonym: "gall bladder epithelial tissue" EXACT [OBOL:automatic] synonym: "gall bladder epithelium" EXACT [] synonym: "gallbladder epithelial tissue" EXACT [OBOL:automatic] synonym: "gallbladder epithelium" EXACT [OBOL:automatic] xref: BTO:0001449 xref: CALOHA:TS-1304 xref: EMAPA:35370 xref: FMA:67711 xref: MA:0001632 xref: NCIT:C49227 xref: UMLS:C1180206 {source="ncithesaurus:Gallbladder_Epithelium"} is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0034932 ! epithelium of biliary system intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002110 ! gallbladder relationship: contributes_to_morphology_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0002031 name: epithelium of bronchus namespace: uberon def: "An epithelium that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bronchi epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchi epithelium" EXACT [OBOL:automatic] synonym: "bronchial epithelium" EXACT [] synonym: "bronchial trunk epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk epithelium" EXACT [OBOL:automatic] synonym: "bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchus epithelium" EXACT [] synonym: "epithelial tissue of bronchi" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchus" EXACT [OBOL:automatic] synonym: "epithelium of bronchi" EXACT [OBOL:automatic] synonym: "epithelium of bronchial trunk" EXACT [OBOL:automatic] xref: BTO:0001845 xref: CALOHA:TS-1240 xref: EFO:0000307 xref: EMAPA:32691 xref: FMA:67782 xref: MA:0001839 xref: NCIT:C32231 xref: UMLS:C0599333 {source="ncithesaurus:Bronchial_Epithelium"} is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002185 ! bronchus relationship: contributes_to_morphology_of UBERON:0002185 ! bronchus relationship: has_part CL:0002209 {source="FMA"} ! intermediate epitheliocyte relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0002036 name: striated muscle tissue namespace: uberon def: "Muscle tissue that contains fibers that are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_muscle] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "striated muscle" EXACT [] xref: AAO:0010762 xref: AEO:0000140 xref: CALOHA:TS-2047 xref: EHDAA2:0003140 xref: EMAPA:36390 xref: FMA:67905 xref: galen:StriatedMuscle xref: MA:0002438 xref: NCIT:C12436 xref: UMLS:C1331262 {source="ncithesaurus:Striated_Muscle_Tissue"} xref: WBbt:0005779 xref: Wikipedia:Striated_muscle is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: composed_primarily_of CL:0000737 ! striated muscle cell relationship: composed_primarily_of CL:0000737 ! striated muscle cell property_value: UBPROP:0000001 "Voluntary muscle tissue arranged in bundles of fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010762", ontology="AAO", source="AAO:CAM"} [Term] id: UBERON:0002040 name: bronchial artery namespace: uberon def: "A systemic artery that supplies the lung with with oxygenated blood." [UBERON:cjm, Wikipedia:Bronchial_artery] comment: Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "arteriae bronchiales" RELATED OMO:0003011 [Wikipedia:Bronchial_artery] synonym: "bronchial arterial tree" EXACT [] synonym: "rami bronchiales partis thoracicae aortae" RELATED OMO:0003011 [Wikipedia:Bronchial_artery] xref: EMAPA:18608 xref: FMA:68109 xref: GAID:477 xref: MA:0001923 xref: MESH:D001981 xref: NCIT:C32230 xref: SCTID:244247009 xref: UMLS:C0006257 {source="ncithesaurus:Bronchial_Artery"} xref: Wikipedia:Bronchial_artery is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: part_of UBERON:0004571 ! systemic arterial system intersection_of: vessel_supplies_blood_to UBERON:0002048 ! lung relationship: has_part UBERON:0004848 ! respiratory system arterial endothelium relationship: has_part UBERON:0012416 ! respiratory system arterial smooth muscle relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002048 ! lung property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002047 name: pontine raphe nucleus namespace: uberon def: "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." [Wikipedia:Pontine_raphe_nucleus] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "nucleus raphe pontis" RELATED OMO:0003011 [NeuroNames:589] synonym: "nucleus raphes pontis" RELATED OMO:0003011 [Wikipedia:Pontine_raphe_nucleus] synonym: "raphe (mediana pontina)" RELATED OMO:0003011 [NeuroNames:589] synonym: "raphe of pons" EXACT [] synonym: "raphe pontis" EXACT OMO:0003011 [FMA:68875, FMA:TA] synonym: "raphe pontis nucleus" RELATED [] xref: BAMS:PnR xref: BAMS:RA-PONS xref: BAMS:RPn xref: BIRNLEX:1110 xref: DHBA:12471 xref: DHBA:12475 xref: FMA:68875 xref: HBA:9159 xref: MA:0001022 xref: MBA:238 xref: neuronames:589 {source="BIRNLEX:1110"} xref: UMLS:C0175423 {source="BIRNLEX:1110"} xref: Wikipedia:Pontine_raphe_nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: part_of UBERON:0003023 ! pontine tegmentum relationship: part_of UBERON:0004684 {source="Wikipedia"} ! raphe nuclei property_value: RO:0002171 UBERON:0002148 {source="ABA"} property_value: RO:0002171 UBERON:0002267 {source="ABA"} property_value: RO:0002171 UBERON:0002587 {source="ABA"} property_value: RO:0002171 UBERON:0003004 {source="ABA"} [Term] id: UBERON:0002048 name: lung namespace: uberon def: "Respiration organ that develops as an outpocketing of the esophagus." [http://orcid.org/0000-0002-6601-2165] comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "pulmo" EXACT OMO:0003011 [] xref: AAO:0000275 xref: AAO:0010567 xref: BTO:0000763 xref: CALOHA:TS-0568 xref: EFO:0000934 xref: EHDAA2:0001042 xref: EHDAA:1554 xref: EHDAA:2205 xref: EMAPA:16728 xref: EV:0100042 xref: FMA:7195 xref: GAID:345 xref: galen:Lung xref: MA:0000415 xref: MAT:0000135 xref: MESH:D008168 xref: MIAA:0000135 xref: NCIT:C12468 xref: SCTID:181216001 xref: UMLS:C0024109 {source="ncithesaurus:Lung"} xref: Wikipedia:Lung xref: XAO:0000119 is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0015212 ! lateral structure relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0000118 ! lung bud relationship: has_part UBERON:0002185 ! bronchus relationship: in_lateral_side_of UBERON:0000170 ! pair of lungs relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of UBERON:0000170 {note="some species only have a single lung"} ! pair of lungs relationship: surrounded_by UBERON:0009778 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! pleural sac property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb xsd:anyURI property_value: RO:0002161 NCBITaxon:32443 {editor="https://orcid.org/0000-0002-9415-5104", source="https://github.com/obophenotype/uberon/issues/701"} property_value: RO:0002161 NCBITaxon:7777 {editor="https://orcid.org/0000-0002-9415-5104", source="https://github.com/obophenotype/uberon/issues/701"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/701 xsd:anyURI property_value: UBPROP:0000001 "Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010567", ontology="AAO", source="AAO:SBH"} property_value: UBPROP:0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000310", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210, DOI:10.1371/journal.pone.0024019 Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D, Gong Z, Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One (2011)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pulmonary" xsd:string property_value: UBPROP:0000008 "respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi" xsd:string [Term] id: UBERON:0002049 name: vasculature namespace: uberon def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [ZFA:0005249] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vascular network" EXACT [FMA:69050] xref: BTO:0003718 xref: FMA:69050 xref: TAO:0005249 xref: ZFA:0005249 is_a: UBERON:0000477 {source="FMA"} ! anatomical cluster relationship: composed_primarily_of UBERON:0000055 ! vessel relationship: has_part UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0007798 ! vascular system property_value: editor_note "see also: vascular system. Consider merging?" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "vascular" xsd:string [Term] id: UBERON:0002050 name: embryonic structure namespace: uberon def: "Anatomical structure that is part of an embryo." [BTO:0000174, ZFIN:curator] subset: efo_slim subset: human_subset subset: inconsistent_with_fma subset: mouse_subset subset: vertebrate_core synonym: "developing embryonic structure" EXACT [FBbt:00004208] synonym: "developing structure" RELATED [] synonym: "embryonale Struktur" RELATED [BTO:0000174] synonym: "embryonic anatomical structure" EXACT [RETIRED_EHDAA2:0003169] synonym: "embryonic structures" RELATED OMO:0003004 [ZFA:0001105] xref: AAO:0000138 xref: BILA:0000034 xref: BTO:0000174 xref: CALOHA:TS-2110 xref: EFO:0000461 xref: FBbt:00004208 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69067 xref: GAID:407 xref: MESH:D004628 xref: NCIT:C13229 xref: RETIRED_EHDAA2:0003169 xref: SCTID:667009 xref: TAO:0001105 xref: UMLS:C0013948 {source="ncithesaurus:Embryonic_Structure"} xref: VSAO:0000178 xref: XAO:0003042 xref: ZFA:0001105 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: UBPROP:0000001 "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000138", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001105", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000178", ontology="VSAO", source="ZFIN:curator"} property_value: UBPROP:0000012 "in FMA embryo is_a embryonic structure" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002057 name: phrenic artery namespace: uberon def: "An artery that supplies the diaphragm." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: uberon_slim xref: EMAPA:37108 {source="MA:th"} xref: FMA:69330 xref: MA:0002019 xref: NCIT:C33320 xref: UMLS:C1181536 {source="ncithesaurus:Phrenic_Artery"} is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: vessel_supplies_blood_to UBERON:0001103 ! diaphragm relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0001103 ! diaphragm property_value: UBPROP:0000008 "In humans this includes the superior and inferior phrenic arteries" xsd:string [Term] id: UBERON:0002061 name: truncus arteriosus namespace: uberon def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." [Wikipedia:Truncus_arteriosus_(embryology)] subset: human_subset subset: mouse_subset subset: uberon_slim xref: EHDAA2:0004143 xref: EMAPA:35887 xref: FMA:70301 xref: GAID:554 xref: MA:0000103 xref: MESH:D014338 xref: NCIT:C34317 xref: SCTID:308828009 xref: UMLS:C1519589 {source="ncithesaurus:Trancus_Arteriosus"} xref: Wikipedia:Truncus_arteriosus_(embryology) is_a: UBERON:0001637 {source="EHDAA2"} ! artery is_a: UBERON:0002050 {source="FMA"} ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel relationship: develops_from UBERON:0005432 {source="EHDAA2"} ! aortic sac relationship: part_of UBERON:0004145 {source="MA"} ! outflow tract relationship: part_of UBERON:0005498 {source="EHDAA2"} ! primitive heart tube property_value: UBPROP:0000012 "assume spelling error for ncit" xsd:string {external_ontology="ncit"} [Term] id: UBERON:0002062 name: endocardial cushion namespace: uberon def: "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Atrioventricular_cushions, ZFIN:curator] comment: GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atrioventricular canal cushion" RELATED [FMA:70302] synonym: "atrioventricular cushion" EXACT [Wikipedia:Endocardial_cushion] synonym: "AV cushion" EXACT [] synonym: "cardiac cushion" EXACT [PMID:15797462] synonym: "endocardial cushion tissue" EXACT [EHDAA2:0000434] synonym: "endocardial cushions" RELATED OMO:0003004 [] xref: EHDAA2:0000434 xref: EHDAA2:0004028 xref: EHDAA:2586 xref: EMAPA:16696 xref: FMA:70302 xref: MA:0000078 xref: MESH:D054089 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: TAO:0001317 xref: VHOG:0000932 xref: Wikipedia:Atrioventricular_cushions xref: XAO:0004189 xref: ZFA:0001317 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0009751 ! cardiac mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest relationship: part_of UBERON:0002165 {source="ZFA"} ! endocardium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png xsd:anyURI property_value: UBPROP:0000001 "Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001317", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001317", ontology="TAO"} property_value: UBPROP:0000003 "(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000932", ontology="VHOG", source="DOI:10.1038/35047564 Stainier DYR, Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics (2001) Figure 3", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002063 name: sinus venosus namespace: uberon def: "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." [PMID:20735616, Wikipedia:Sinus_venosus] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "inflow tract" BROAD [ZFA:0000154] synonym: "sinus venarum" RELATED [Wikipedia:Sinus_venosus] synonym: "sinus venosus cordis" RELATED OMO:0003011 [Wikipedia:Sinus_venosus] synonym: "venarum" RELATED [Wikipedia:Sinus_venosus] synonym: "venarum sinus" RELATED [Wikipedia:Sinus_venosus] synonym: "venosus" RELATED [Wikipedia:Sinus_venosus] xref: AAO:0010505 xref: EHDAA2:0001839 xref: EHDAA:480 xref: EMAPA:16237 xref: FMA:70303 xref: NCIT:C34299 xref: NCIT:C34300 xref: TAO:0000154 xref: UMLS:C0225857 {source="ncithesaurus:Sinus_Venarum"} xref: UMLS:C0231084 {source="ncithesaurus:Sinus_Venosus"} xref: VHOG:0000177 xref: Wikipedia:Sinus_venosus xref: ZFA:0000154 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber relationship: develops_from UBERON:0004141 ! heart tube relationship: develops_from UBERON:0007278 ! presumptive sinus venosus relationship: immediate_transformation_of UBERON:0007278 {source="Bgee:AN"} ! presumptive sinus venosus relationship: part_of UBERON:0002350 {source="VHOG"} ! conducting system of heart property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png xsd:anyURI property_value: UBPROP:0000001 "Heart region collecting blood from the paired common cardinal veins and delivering to the atrium. One of four components of the heart. The sinus venosus also acts as a pacemaker and is the first to contract. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000154", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the circulatory system which receives blood from the systemic veins and contracts to pump the blood into the atrium of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010505", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000177", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In fish, receives venous blood from the systemic circulation through paired hepatic veins, anterior jugular veins and Cuvierian ducts[PMID:20735616]" xsd:string property_value: UBPROP:0000008 "In humans, it exists distinctly only in the embryonic heart, where it is found between the two venae cavae. In the adult, it is incorporated into the wall of the right atrium to form a smooth part called the sinus venarum, also known as the venarum sinus, which is separated from the rest of the atrium by a ridge of fibres called the crista terminalis. The sinus venosus also forms the SA node and the coronary sinus. In the embryo, the thin walls of the sinus venosus are connected below with the right ventricle, and medially with the left atrium, but are free in the rest of their extent. It receives blood from the vitelline vein, umbilical vein and common cardinal vein. It originally starts as a paired structure but shifts towards associating only with the right atrium as the embryonic heart develops. The left portion shrinks in size and eventually forms the coronary sinus and oblique vein of the left atrium, whereas the right part becomes incorporated into the right atrium to form the sinus venarmu" xsd:string property_value: UBPROP:0000008 "In zebrafish, the sinus venosus also acts as a pacemaker and is the first to contract" xsd:string {source="ZFA:0000154"} [Term] id: UBERON:0002067 name: dermis namespace: uberon def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corium" RELATED OMO:0003011 [BTO:0000294, Wikipedia:Dermis] synonym: "cutis" RELATED [BTO:0000294] synonym: "vertebrate dermis" EXACT [] xref: AAO:0000128 xref: BTO:0000294 xref: CALOHA:TS-2076 xref: EFO:0000953 xref: EMAPA:17527 xref: EV:0100154 xref: FMA:70323 xref: GAID:1321 xref: MA:0000152 xref: MAT:0000153 xref: MESH:D020405 xref: MIAA:0000153 xref: NCIT:C12701 xref: SCTID:361696001 xref: TAO:0001119 xref: UMLS:C0011646 {source="ncithesaurus:Dermis"} xref: VHOG:0000108 xref: Wikipedia:Dermis xref: XAO:0000217 xref: ZFA:0001119 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer relationship: composed_primarily_of UBERON:0002384 ! connective tissue relationship: deep_to UBERON:0001003 ! skin epidermis relationship: develops_from UBERON:0002199 ! integument relationship: develops_from UBERON:0002416 ! integumental system relationship: develops_from UBERON:0010083 ! future dermis relationship: has_part GO:0071953 ! elastic fiber relationship: has_part UBERON:0011860 ! collection of collagen fibrils relationship: immediate_transformation_of UBERON:0010083 {evidence="definitional"} ! future dermis relationship: part_of UBERON:0002097 {source="FMA"} ! skin of body relationship: superficial_to UBERON:0002072 ! hypodermis property_value: editor_note "Consider adding a layer-of-skin grouping class for all skin layers" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001119", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000108", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "dermal" xsd:string [Term] id: UBERON:0002072 name: hypodermis namespace: uberon def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [Wikipedia:Hypodermis] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hypoderm" EXACT [] synonym: "sub-tegumental tissue" RELATED [BTO:0004525] synonym: "subcutaneous tissue" RELATED [Wikipedia:Hypodermis] synonym: "subcutis" RELATED [] synonym: "subtegumental tissue" RELATED [BTO:0004525] synonym: "superficial fascia" RELATED INCONSISTENT [] synonym: "tela subcutanea" RELATED OMO:0003011 [Wikipedia:Hypodermis] synonym: "vertebrate hypodermis" EXACT [] xref: BTO:0001314 xref: CALOHA:TS-2366 xref: EMAPA:37505 {source="MA:th"} xref: FMA:70544 xref: MESH:D040521 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C33645 xref: TAO:0001136 xref: UMLS:C0278403 {source="ncithesaurus:Subcutis"} xref: Wikipedia:Hypodermis xref: ZFA:0001136 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer relationship: composed_primarily_of UBERON:0001013 ! adipose tissue relationship: composed_primarily_of UBERON:0011825 {source="FMA-modified"} ! loose connective tissue relationship: deep_to UBERON:0002067 ! dermis relationship: part_of UBERON:0002199 {source="ZFA"} ! integument relationship: superficial_to UBERON:0001015 ! musculature property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001136", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]." xsd:string {source="FMA:70544"} property_value: UBPROP:0000007 "hypodermal" xsd:string property_value: UBPROP:0000007 "subcutaneous" xsd:string property_value: UBPROP:0000007 "subcutaneus" xsd:string property_value: UBPROP:0000012 "BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument." xsd:string {external_ontology="BTO"} [Term] id: UBERON:0002075 name: viscus namespace: uberon def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." [BTO:0001491, https://github.com/obophenotype/mouse-anatomy-ontology/issues/14, Wikipedia:Viscus] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "splanchnic tissue" RELATED [BTO:0001491] synonym: "viscera" RELATED [] synonym: "visceral organ" EXACT [RETIRED_EHDAA2:0002201] synonym: "visceral organ system" EXACT [MA:0000019] synonym: "visceral tissue" RELATED [BTO:0001491] xref: AAO:0010386 xref: BTO:0001491 xref: EHDAA:512 xref: EMAPA:16245 xref: FMA:7085 xref: MA:0000019 xref: MESH:D014781 xref: NCIT:C28287 xref: RETIRED_EHDAA2:0002201 xref: SCTID:118760003 xref: UMLS:C0042779 {source="ncithesaurus:Viscera"} xref: Wikipedia:Viscus xref: XAO:0003034 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: located_in UBERON:0002323 ! coelemic cavity lumen relationship: located_in UBERON:0002323 ! coelemic cavity lumen property_value: UBPROP:0000001 "An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010386", ontology="AAO", source="BTO:0001491"} property_value: UBPROP:0000012 "general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002078 name: right cardiac atrium namespace: uberon def: "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Right_atrium] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "atrium dextrum" RELATED OMO:0003011 [Wikipedia:Right_atrium] synonym: "cardiac right atrium" EXACT [] synonym: "heart right atrium" EXACT [MA:0000075] synonym: "right atrium" EXACT [VHOG:0000328] synonym: "right atrium of heart" EXACT [] synonym: "right cardiac atrium" EXACT [] xref: AAO:0010248 xref: BTO:0001703 xref: EHDAA2:0000290 xref: EMAPA:17321 xref: FMA:7096 xref: galen:RightAtrium xref: MA:0000075 xref: NCIT:C12868 xref: SCTID:244383003 xref: UMLS:C0225844 {source="ncithesaurus:Right_Atrium"} xref: VHOG:0000328 xref: Wikipedia:Right_atrium xref: XAO:0003192 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: in_right_side_of UBERON:0000948 ! heart relationship: connected_to UBERON:0004537 ! blood vasculature relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA]" xsd:string {source="FMA:7096"} property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000328", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0002079 name: left cardiac atrium namespace: uberon def: "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Left_atrium] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "atrium sinistrum" EXACT OMO:0003011 [Wikipedia:Left_atrium] synonym: "cardiac left atrium" EXACT [] synonym: "heart left atrium" EXACT [MA:0000074] synonym: "left atrium" EXACT [VHOG:0000369] synonym: "left atrium of heart" EXACT [] synonym: "left cardiac atrium" EXACT [] xref: AAO:0010247 xref: BTO:0001702 xref: EHDAA2:0000275 xref: EMAPA:17315 xref: FMA:7097 xref: galen:LeftAtrium xref: MA:0000074 xref: NCIT:C12869 xref: SCTID:244387002 xref: UMLS:C0225860 {source="ncithesaurus:Left_Atrium"} xref: VHOG:0000369 xref: Wikipedia:Left_atrium xref: XAO:0003191 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: in_left_side_of UBERON:0000948 ! heart relationship: connected_to UBERON:0004537 ! blood vasculature relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA]" xsd:string {source="FMA:7097"} property_value: UBPROP:0000001 "The chamber of the heart that receives blood from the lungs[XAO:EJS]." xsd:string {source="XAO:EJS"} property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000369", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0002080 name: heart right ventricle namespace: uberon def: "A cardiac ventricle that is in the right side of the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cardiac right ventricle" EXACT [] synonym: "right cardiac ventricle" RELATED [EMAPA:17340] synonym: "right ventricle" EXACT [FMA:7098] synonym: "right ventricle of heart" EXACT [] synonym: "ventriculus dexter" RELATED OMO:0003011 [Wikipedia:Right_ventricle] xref: BTO:0001630 xref: CALOHA:TS-0443 xref: EHDAA2:0000196 xref: EMAPA:17340 xref: FMA:7098 xref: galen:RightVentricle xref: MA:0000093 xref: NCIT:C12870 xref: SCTID:244384009 xref: UMLS:C0225883 {source="ncithesaurus:Right_Ventricle"} xref: VHOG:0000717 xref: Wikipedia:Right_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: in_right_side_of UBERON:0000948 ! heart relationship: connected_to UBERON:0004537 ! blood vasculature relationship: develops_from UBERON:0009889 {source="PMID:17276708"} ! secondary heart field relationship: has_developmental_contribution_from UBERON:0004706 {source="cjm"} ! bulbus cordis relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000717", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI property_value: UBPROP:0000008 "In mammals continuous with the pulmonary arteries" xsd:string [Term] id: UBERON:0002081 name: cardiac atrium namespace: uberon def: "Cardiac chamber in which blood enters the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart_atrium] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atria" EXACT OMO:0003004 [] synonym: "atrial tissue" RELATED [BTO:0000903] synonym: "atrium" EXACT [ZFA:0000471] synonym: "atrium of heart" EXACT [] synonym: "cardiac atria" EXACT OMO:0003004 [] synonym: "heart atrium" EXACT [] xref: AAO:0010246 xref: BTO:0000903 xref: CALOHA:TS-0437 xref: EFO:0000277 xref: EHDAA2:0000154 xref: EHDAA:1265 xref: EMAPA:16688 xref: EV:0100019 xref: FMA:7099 xref: GAID:555 xref: galen:Atrium xref: MA:0000073 xref: MAT:0000496 xref: MESH:D006325 xref: NCIT:C12728 xref: SCTID:261405004 xref: TAO:0000471 xref: UMLS:C0018792 {source="ncithesaurus:Cardiac_Atrium"} xref: VHOG:0000175 xref: Wikipedia:Heart_atrium xref: ZFA:0000471 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber relationship: contributes_to_morphology_of UBERON:0000948 ! heart relationship: develops_from UBERON:0004141 ! heart tube relationship: develops_from UBERON:0010227 ! future cardiac atrium relationship: immediate_transformation_of UBERON:0010227 ! future cardiac atrium property_value: UBPROP:0000001 "One of four heart chambers.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000471", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010246", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000175", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002082 name: cardiac ventricle namespace: uberon def: "Cardiac chamber through which blood leaves the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Ventricle_(heart)] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "heart ventricle" EXACT [] synonym: "lower chamber of heart" EXACT [] synonym: "ventricle" BROAD [] synonym: "ventricle of heart" EXACT [] xref: AAO:0010249 xref: BTO:0000862 xref: CALOHA:TS-0444 xref: EFO:0000317 xref: EHDAA2:0004164 xref: EHDAA:1912 xref: EMAPA:17331 xref: EV:0100020 xref: FMA:7100 xref: GAID:568 xref: galen:Ventricle xref: MA:0000091 xref: MAT:0000497 xref: MESH:D006352 xref: NCIT:C12730 xref: SCTID:277699000 xref: TAO:0000009 xref: UMLS:C0018827 {source="ncithesaurus:Cardiac_Ventricle"} xref: VHOG:0000435 xref: Wikipedia:Ventricle_(heart) xref: XAO:0003193 xref: ZFA:0000009 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber relationship: contributes_to_morphology_of UBERON:0000948 ! heart relationship: develops_from UBERON:0004141 ! heart tube relationship: develops_from UBERON:0006283 ! future cardiac ventricle relationship: immediate_transformation_of UBERON:0006283 {source="Bgee:AN"} ! future cardiac ventricle property_value: UBPROP:0000001 "A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010249", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "One of four heart chambers.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000009", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000435", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002084 name: heart left ventricle namespace: uberon def: "A cardiac ventricle that is in the left side of the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cardiac left ventricle" EXACT [] synonym: "left cardiac ventricle" EXACT [] synonym: "left ventricle" EXACT [FMA:7101] synonym: "left ventricle of heart" EXACT [] synonym: "ventriculus sinister cordis" RELATED OMO:0003011 [Wikipedia:Left_ventricle] xref: BTO:0001629 xref: CALOHA:TS-0439 xref: EHDAA2:0002178 xref: EMAPA:17337 xref: FMA:7101 xref: galen:LeftVentricle xref: MA:0000092 xref: NCIT:C12871 xref: SCTID:244385005 xref: UMLS:C0225897 {source="ncithesaurus:Left_Ventricle"} xref: VHOG:0000718 xref: Wikipedia:Left_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: in_left_side_of UBERON:0000948 ! heart relationship: connected_to UBERON:0004537 ! blood vasculature relationship: continuous_with UBERON:0000947 ! aorta relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000718", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000718", ontology="VHOG", source="DOI:10.1126/science.1190181 Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L, Early chordate origins of the vertebrate second heart field. Science (2010)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI property_value: UBPROP:0000008 "In mammals continuous with aorta" xsd:string [Term] id: UBERON:0002085 name: interatrial septum namespace: uberon def: "A cardiac septum that divides the left and right atria of the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "atrial septum" EXACT [] synonym: "atrium septum" EXACT [] synonym: "interatrial septal wall" EXACT [] xref: EHDAA2:0000838 xref: EHDAA:1896 xref: EMAPA:17011 xref: FMA:7108 xref: galen:InteratrialSeptum xref: MA:0000084 xref: NCIT:C32818 xref: SCTID:362016003 xref: UMLS:C0225836 {source="ncithesaurus:Interatrial_Septum"} xref: VHOG:0000385 xref: Wikipedia:Interatrial_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: adjacent_to UBERON:0002078 ! right cardiac atrium intersection_of: adjacent_to UBERON:0002079 ! left cardiac atrium relationship: adjacent_to UBERON:0002078 ! right cardiac atrium relationship: adjacent_to UBERON:0002079 ! left cardiac atrium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png xsd:anyURI property_value: UBPROP:0000001 "The partition separating the right and left atria of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000385", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/interatrial+septum"} property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000385", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002090 name: postcranial axial skeleton namespace: uberon def: "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." [https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957, https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834, ZFA:0000317] comment: previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "axial skeleton" BROAD [FMA:71221, https://github.com/obophenotype/uberon/wiki/The-axial-skeleton] synonym: "post-cranial axial skeleton" EXACT [] xref: AAO:0000034 xref: EFO:0000942 xref: EHDAA2:0000161 xref: EHDAA:5049 xref: EMAPA:37721 {source="MA:th"} xref: FMA:71221 xref: MA:0002986 xref: MAT:0000148 xref: MESH:D013131 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000148 xref: TAO:0000317 xref: VHOG:0000317 xref: VSAO:0000093 xref: XAO:0003073 xref: ZFA:0000317 is_a: UBERON:0010912 ! subdivision of skeleton relationship: develops_from UBERON:0003089 ! sclerotome relationship: part_of UBERON:0005944 ! axial skeleton plus cranial skeleton relationship: part_of UBERON:0011138 ! postcranial axial skeletal system property_value: seeAlso http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton xsd:anyURI property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000093", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000034", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000317", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000317", ontology="VHOG", source="DOI:10.1186/1742-9994-8-4 Schilling N, Evolution of the axial system in craniates: morphology and function of the perivertebral musculature. Frontiers in Zoology (2011)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002091 name: appendicular skeleton namespace: uberon def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003, Wikipedia:Appendicular_skeleton] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "appendicular skeleton" EXACT [] synonym: "entire appendicular skeleton" EXACT [https://github.com/obophenotype/uberon/issues/59] synonym: "paired fin skeleton" NARROW SENSU [] synonym: "skeleton appendiculare" RELATED OMO:0003011 [Wikipedia:Appendicular_skeleton] xref: AAO:0000747 xref: EFO:0000951 xref: EMAPA:32729 xref: FMA:71222 xref: MA:0000290 xref: MAT:0000278 xref: MIAA:0000278 xref: NCIT:C49477 xref: SCTID:322050006 xref: UMLS:C0222646 {source="ncithesaurus:Appendicular_Skeleton"} xref: VSAO:0000076 xref: Wikipedia:Appendicular_skeleton xref: XAO:0003166 is_a: UBERON:0010912 ! subdivision of skeleton relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system relationship: in_taxon NCBITaxon:7776 ! Gnathostomata relationship: overlaps UBERON:0000026 ! appendage relationship: part_of UBERON:0011249 ! appendicular skeletal system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton xsd:anyURI property_value: UBPROP:0000001 "Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000076", ontology="VSAO", source="PSPUB:0000170", source="https://orcid.org/0000-0002-6601-2165"} property_value: UBPROP:0000001 "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000027", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000001 "The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000747", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000012 "ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002094 name: interventricular septum namespace: uberon def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." [FMA:7133] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "heart interventricular septum" EXACT [MA:0000085] synonym: "heart ventricular septum" EXACT [MA:0000085] synonym: "interventricular septum of heart" RELATED [BTO:0002483] synonym: "interventriculare cordis" RELATED [BTO:0002483] synonym: "intraventricular septum" RELATED [Wikipedia:Interventricular_septum] synonym: "s. interventriculare cordis" RELATED OMO:0003011 [Wikipedia:Interventricular_septum] synonym: "septum inferius" RELATED [Wikipedia:Interventricular_septum] synonym: "septum membranaceum" RELATED [Wikipedia:Interventricular_septum] synonym: "ventricle septum" RELATED [] synonym: "ventricular septum" RELATED [MA:0000085, Wikipedia:Interventricular_septum] xref: BTO:0002483 xref: EFO:0001956 xref: EHDAA:2603 xref: EMAPA:17333 xref: FMA:7133 xref: galen:InterventricularSeptum xref: MA:0000085 xref: NCIT:C32874 xref: SCTID:362019005 xref: UMLS:C0225870 {source="ncithesaurus:Interventricular_Septum"} xref: VHOG:0000386 xref: Wikipedia:Interventricular_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: adjacent_to UBERON:0002080 ! heart right ventricle intersection_of: adjacent_to UBERON:0002084 ! heart left ventricle relationship: adjacent_to UBERON:0002080 ! heart right ventricle relationship: adjacent_to UBERON:0002084 ! heart left ventricle property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The partition separating the right and left ventricles of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000386", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/interventricular+septum"} property_value: UBPROP:0000003 "The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000386", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.430", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999)" xsd:string {source="ISBN:0124020607"} [Term] id: UBERON:0002097 name: skin of body namespace: uberon def: "The organ covering the body that consists of the dermis and epidermis." [UBERON:cjm] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "entire integument" RELATED [] synonym: "entire skin" EXACT [] synonym: "integument" RELATED [] synonym: "integumental organ" RELATED [] synonym: "pelt" RELATED [] synonym: "skin" RELATED [] synonym: "skin organ" EXACT [] xref: BTO:0001253 xref: CALOHA:TS-0934 xref: EFO:0000962 xref: EHDAA2:0001844 xref: EMAPA:17525 xref: FMA:7163 xref: galen:Skin xref: MESH:D012867 xref: MFMO:0000099 xref: NCIT:C12470 xref: SCTID:181469002 xref: UMLS:C1123023 {source="ncithesaurus:Skin"} xref: Wikipedia:Skin xref: XAO:0000023 is_a: UBERON:0000062 ! organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: composed_primarily_of UBERON:0000014 ! zone of skin relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer relationship: part_of UBERON:0002199 ! integument property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/skin-female/v1.4/assets/3d-vh-f-skin.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/skin-male/v1.3/assets/3d-vh-m-skin.glb xsd:anyURI property_value: IAO:0000232 "consider 'integumentary system' for invertebrates" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "MA uses the term skin to refer to what is called here: zone of skin" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002099 name: cardiac septum namespace: uberon def: "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." [MESH:A07.541.459] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cardiac septa" EXACT OMO:0003004 [] synonym: "heart septa" EXACT OMO:0003004 [] synonym: "heart septum" EXACT [] synonym: "septum of heart" EXACT [] synonym: "spiral septa" RELATED OMO:0003004 [XAO:0004141] xref: EMAPA:35400 xref: FMA:7180 xref: GAID:562 xref: MA:0000083 xref: MESH:D006346 xref: NCIT:C49485 xref: SCTID:362014000 xref: UMLS:C0018819 {source="ncithesaurus:Heart_Septum"} is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: part_of UBERON:0000948 ! heart relationship: adjacent_to UBERON:0004151 ! cardiac chamber relationship: contributes_to_morphology_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: UBPROP:0000008 "'Terrestrial vertebrates have divided hearts in which septae separate the oxygenated and deoxygenated blood within the pulmonary and systemic circulations'" xsd:string property_value: UBPROP:0000012 "in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this" xsd:string {external_ontology="GO"} [Term] id: UBERON:0002100 name: trunk namespace: uberon def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [TAO:0001115, UBERONREF:0000006, Wikipedia:Torso] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Rumpf" RELATED [BTO:0001493] synonym: "thoracolumbar region" EXACT [] synonym: "torso" EXACT [] synonym: "trunk region" EXACT [XAO:0000054] xref: AAO:0010339 xref: BILA:0000116 xref: BTO:0001493 xref: CALOHA:TS-1071 xref: EFO:0000966 xref: EMAPA:31857 xref: FMA:7181 xref: galen:Trunk xref: MA:0000004 xref: MAT:0000296 xref: MIAA:0000296 xref: NCIT:C33816 xref: SCTID:262225004 xref: TAO:0001115 xref: UMLS:C0460005 {source="ncithesaurus:Trunk"} xref: Wikipedia:Torso xref: XAO:0000054 xref: XAO:0003025 xref: ZFA:0001115 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: has_part UBERON:0000915 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! thoracic segment of trunk relationship: has_part UBERON:0000916 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! abdomen relationship: part_of UBERON:0013702 ! body proper property_value: RO:0002171 UBERON:0000026 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} property_value: RO:0002171 UBERON:0000033 property_value: UBPROP:0000001 "Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010339", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001115", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0002104 name: visual system namespace: uberon alt_id: UBERON:0007036 def: "The sensory system subserving the sense of vision." [NIFSTD:FMAID_7191] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "photosensory system" EXACT [BILA:0000140] synonym: "visual organ system" EXACT [] xref: AAO:0000632 xref: BILA:0000140 xref: EMAPA:36003 xref: FMA:7191 xref: http://uri.neuinfo.org/nif/nifstd/FMAID_7191 xref: MA:0002444 xref: NCIT:C12888 xref: SCTID:281831001 xref: TAO:0001127 xref: UMLS:C0587900 {source="ncithesaurus:Visual_System"} xref: Wikipedia:Visual_system xref: XAO:0003198 xref: ZFA:0001127 is_a: UBERON:0001032 ! sensory system relationship: capable_of_part_of GO:0007601 ! visual perception property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The sensory system used for sight.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000632", ontology="AAO", source="AAO:EJS"} [Term] id: UBERON:0002105 name: vestibulo-auditory system namespace: uberon def: "Sensory system responsible for the perception of spatial orientation and auditory stimuli." [ZFA:0001138] subset: functional_classification subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "auditory organ system" EXACT [] synonym: "auditory system" RELATED [] synonym: "auditory/vestibular system" RELATED [] synonym: "vestibuloauditory system" EXACT [] synonym: "vestibuloauditory system" RELATED [] xref: AAO:0000631 xref: EMAPA:37985 {source="MA:th"} xref: FMA:78500 xref: TAO:0001138 xref: XAO:0003195 xref: ZFA:0001138 is_a: UBERON:0001032 ! sensory system relationship: capable_of_part_of GO:0007605 ! sensory perception of sound property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg xsd:anyURI property_value: UBPROP:0000001 "The sensory system used for balance and hearing.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000631", ontology="AAO", source="AAO:EJS"} [Term] id: UBERON:0002106 name: spleen namespace: uberon def: "The organ that functions to filter blood and to store red corpuscles and platelets." [ISBN:0-683-40008-8, MP:0000689] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lien" RELATED OMO:0003011 [Wikipedia:Spleen] xref: AAO:0010395 xref: BTO:0001281 xref: CALOHA:TS-0956 xref: EFO:0000869 xref: EMAPA:18767 xref: EV:0100055 xref: FMA:7196 xref: GAID:1289 xref: galen:Spleen xref: MA:0000141 xref: MAT:0000085 xref: MESH:D013154 xref: MIAA:0000085 xref: NCIT:C12432 xref: SCTID:181279003 xref: TAO:0000436 xref: UMLS:C0037993 {source="ncithesaurus:Spleen"} xref: VHOG:0000120 xref: Wikipedia:Spleen xref: XAO:0000328 xref: ZFA:0000436 is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0017672 ! abdominal viscera relationship: develops_from UBERON:0006293 ! spleen primordium relationship: in_taxon NCBITaxon:7776 {source="multiple sources - true spleen appear in jawed vertebrates"} ! Gnathostomata property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/spleen-female/v1.3/assets/3d-vh-f-spleen.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/spleen-male/v1.3/assets/3d-vh-m-spleen.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An organ involved in red blood cell filtration and immune response.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010395", ontology="AAO", source="AAO:BMZ"} property_value: UBPROP:0000003 "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000120", ontology="VHOG", source="ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "lienal" xsd:string property_value: UBPROP:0000007 "splenic" xsd:string property_value: UBPROP:0000008 "In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron" xsd:string property_value: UBPROP:0000008 "Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)" xsd:string {source="PMID:20959416"} property_value: UBPROP:0000009 "It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells" xsd:string [Term] id: UBERON:0002107 name: liver namespace: uberon def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "iecur" RELATED OMO:0003011 [Wikipedia:Liver] synonym: "jecur" RELATED OMO:0003011 [Wikipedia:Liver] xref: AAO:0010111 xref: BTO:0000759 xref: CALOHA:TS-0564 xref: EFO:0000887 xref: EHDAA2:0000997 xref: EHDAA:2197 xref: EMAPA:16846 xref: EV:0100089 xref: FMA:7197 xref: GAID:288 xref: galen:Liver xref: MA:0000358 xref: MAT:0000097 xref: MESH:D008099 xref: MIAA:0000097 xref: NCIT:C12392 xref: SCTID:181268008 xref: TAO:0000123 xref: UMLS:C0023884 {source="ncithesaurus:Liver"} xref: VHOG:0000257 xref: Wikipedia:Liver xref: XAO:0000133 xref: ZFA:0000123 is_a: UBERON:0002365 {source="BTO", source="EHDAA2", source="GO-def"} ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006925 ! digestive system gland relationship: contributes_to_morphology_of UBERON:0002423 ! hepatobiliary system relationship: develops_from UBERON:0004161 {source="EHDAA2"} ! septum transversum relationship: develops_from UBERON:0008836 {source="http://www.stembook.org/node/512"} ! liver bud relationship: has_part UBERON:0004647 ! liver lobule relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: overlaps UBERON:0002405 {source="ZFA-weakened"} ! immune system relationship: part_of UBERON:0002423 {source="ZFA"} ! hepatobiliary system relationship: produces UBERON:0001970 ! bile relationship: site_of GO:0002384 ! hepatic immune response relationship: site_of GO:0005978 ! glycogen biosynthetic process relationship: site_of GO:0005980 ! glycogen catabolic process property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Organ which secretes bile and participates in formation of certain blood proteins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010111", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010111", ontology="AAO"} property_value: UBPROP:0000003 "All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000257", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.526, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "hepatic" xsd:string property_value: UBPROP:0000008 "An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003)." xsd:string property_value: UBPROP:0000008 "The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates." xsd:string property_value: UBPROP:0000009 "secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." xsd:string property_value: UBPROP:0000012 "Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function." xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0002108 name: small intestine namespace: uberon def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [ISBN:0073040584, Wikipedia:Small_intestine] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior intestine" RELATED [] synonym: "intestinum tenue" RELATED OMO:0003011 [BTO:0000651, Wikipedia:Small_intestine] synonym: "mid intestine" RELATED [] synonym: "small bowel" EXACT [] synonym: "small intestine" EXACT [] xref: AAO:0010397 xref: BTO:0000651 xref: CALOHA:TS-0942 xref: EFO:0000841 xref: EMAPA:32834 xref: EV:0100072 xref: FMA:7200 xref: GAID:313 xref: galen:SmallIntestine xref: MA:0000337 xref: MAT:0000047 xref: MESH:D007421 xref: MIAA:0000047 xref: NCIT:C12386 xref: SCTID:181250005 xref: TAO:0001323 xref: UMLS:C0021852 {source="ncithesaurus:Small_Intestine"} xref: VHOG:0000055 xref: Wikipedia:Small_intestine xref: XAO:0000130 xref: ZFA:0001323 is_a: UBERON:0004921 {order="2", source="cjm"} ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: contributes_to_morphology_of UBERON:0000160 ! intestine relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000160 ! intestine property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001323", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000055", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002110 name: gallbladder namespace: uberon def: "An organ that aids digestion and stores bile produced by the liver[WP]." [Wikipedia:Gallbladder] comment: Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) subset: efo_slim subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cholecyst" EXACT [WikipediaVersioned:Gallbladder&oldid=1092217922] synonym: "gall bladder" EXACT [] synonym: "vesica biliaris" RELATED OMO:0003011 [Wikipedia:Gallbladder] synonym: "vesica fellea" RELATED OMO:0003011 [Wikipedia:Gallbladder] xref: AAO:0010114 xref: BTO:0000493 xref: CALOHA:TS-0394 xref: EFO:0000853 xref: EHDAA2:0000699 xref: EHDAA:8062 xref: EMAPA:17202 xref: EV:0100090 xref: FMA:7202 xref: galen:Gallbladder xref: MA:0000356 xref: MAT:0000072 xref: MESH:D005704 xref: MIAA:0000072 xref: NCIT:C12377 xref: SCTID:181269000 xref: TAO:0000208 xref: UMLS:C0016976 {source="ncithesaurus:Gallbladder"} xref: VHOG:0000221 xref: Wikipedia:Gallbladder xref: XAO:0000135 xref: ZFA:0000208 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera is_a: UBERON:0018707 {source="BTO"} ! bladder organ relationship: contributes_to_morphology_of UBERON:0001173 ! biliary tree relationship: develops_from UBERON:0004912 ! biliary bud relationship: develops_from UBERON:0006242 {evidence="definitional"} ! gallbladder primordium relationship: part_of UBERON:0002294 ! biliary system property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:10114 {source="ISBN:9780120749034"} property_value: RO:0002161 NCBITaxon:8801 {source="GOC:mr", source="ISBN:9781840761122"} property_value: RO:0002161 NCBITaxon:8930 {source="GOC:mr", source="ISBN:9781840761122"} property_value: UBPROP:0000001 "Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000221", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010114", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010114", ontology="AAO"} property_value: UBPROP:0000003 "The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000221", ontology="VHOG", source="DOI:10.1002/(SICI)1097-0029(19970915)38:6<571::AID-JEMT3>3.0.CO;2-I Oldham-Ott CK, Gilloteaux J, Comparative morphology of the gallbladder and biliary tract in vertebrates: Variation in structure, homology in function and gallstones. Microscopy research and technique (1997)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002111 name: artery smooth muscle tissue namespace: uberon def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arterial smooth muscle" EXACT [BTO:0000087] synonym: "arterial smooth muscle cell" RELATED [BTO:0000087] synonym: "artery smooth muscle" EXACT [] synonym: "artery smooth muscle tissue" EXACT [] synonym: "smooth muscle of artery" EXACT [FMA:72024] xref: BTO:0000087 xref: CALOHA:TS-1198 xref: EMAPA:36285 xref: FMA:72024 xref: MA:0000708 xref: NCIT:C49195 xref: UMLS:C1706851 {source="ncithesaurus:Artery_Smooth_Muscle_Tissue"} is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] id: UBERON:0002112 name: smooth muscle of esophagus namespace: uberon def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "esophageal smooth muscle" EXACT [] synonym: "esophagus involuntary muscle" EXACT [OBOL:automatic] synonym: "esophagus non-striated muscle" EXACT [OBOL:automatic] synonym: "esophagus smooth muscle" EXACT [] synonym: "esophagus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "gullet involuntary muscle" EXACT [OBOL:automatic] synonym: "gullet non-striated muscle" EXACT [OBOL:automatic] synonym: "gullet smooth muscle" EXACT [OBOL:automatic] synonym: "gullet smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of esophagus" EXACT [OBOL:automatic] synonym: "involuntary muscle of gullet" EXACT [OBOL:automatic] synonym: "involuntary muscle of oesophagus" EXACT [OBOL:automatic] synonym: "non-striated muscle of esophagus" EXACT [OBOL:automatic] synonym: "non-striated muscle of gullet" EXACT [OBOL:automatic] synonym: "non-striated muscle of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus involuntary muscle" EXACT [OBOL:automatic] synonym: "oesophagus non-striated muscle" EXACT [OBOL:automatic] synonym: "oesophagus smooth muscle" RELATED [] synonym: "oesophagus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of gullet" EXACT [OBOL:automatic] synonym: "smooth muscle of oesophagus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of esophagus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gullet" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of oesophagus" EXACT [OBOL:automatic] xref: EMAPA:35323 xref: FMA:72025 xref: MA:0001573 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001043 ! esophagus relationship: contributes_to_morphology_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0003832 ! esophagus muscle [Term] id: UBERON:0002114 name: duodenum namespace: uberon def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [ISBN:0815318960, Wikipedia:Duodenum] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "proximal intestine" RELATED [BTO:0000365] synonym: "upper intestine" RELATED [BTO:0000365] xref: AAO:0010402 xref: BTO:0000365 xref: CALOHA:TS-0214 xref: EFO:0000851 xref: EMAPA:18852 xref: EV:0100073 xref: FMA:7206 xref: GAID:284 xref: galen:Duodenum xref: MA:0000338 xref: MAT:0000044 xref: MESH:D004386 xref: MIAA:0000044 xref: NCIT:C12263 xref: SCTID:181247007 xref: UMLS:C0013303 {source="ncithesaurus:Duodenum"} xref: VHOG:0000052 xref: Wikipedia:Duodenum xref: XAO:0000236 is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract relationship: continuous_with UBERON:0001166 ! pylorus relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine relationship: proximalmost_part_of UBERON:0002108 ! small intestine property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb xsd:anyURI property_value: RO:0002161 NCBITaxon:7955 {source="ZFA:0000348"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000052", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "duodenal" xsd:string property_value: UBPROP:0000008 "In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum." xsd:string {scope="NCBITaxon:32443", source="Wikipedia:Duodenum"} property_value: UBPROP:0000008 "In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz." xsd:string {scope="NCBITaxon:9606", source="Wikipedia:Duodenum"} [Term] id: UBERON:0002118 name: right ovary namespace: uberon def: "An ovary that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:37367 {source="MA:th"} xref: FMA:7213 xref: MA:0001705 xref: NCIT:C33487 xref: SCTID:280123002 xref: UMLS:C0227873 {source="ncithesaurus:Right_Ovary"} is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism relationship: in_right_side_of UBERON:0000468 ! multicellular organism property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/ovary-female-right/v1.3/assets/3d-vh-f-ovary-r.glb xsd:anyURI property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0002119 name: left ovary namespace: uberon def: "An ovary that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:37366 {source="MA:th"} xref: FMA:7214 xref: MA:0001704 xref: NCIT:C32969 xref: SCTID:280124008 xref: UMLS:C0227874 {source="ncithesaurus:Left_Ovary"} is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism relationship: in_left_side_of UBERON:0000468 ! multicellular organism property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/ovary-female-left/v1.3/assets/3d-vh-f-ovary-l.glb xsd:anyURI property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI property_value: UBPROP:0000008 "In some elasmobranchs, the left ovary does not mature, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" xsd:string {source="Wikipedia:Ovary#In_other_animals"} [Term] id: UBERON:0002128 name: superior olivary complex namespace: uberon def: "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." [ISBN:0-19-502694-2, Wikipedia:Superior_olivary_complex] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "nucleus olivaris superior" EXACT OMO:0003011 [FMA:72247, FMA:TA] synonym: "regio olivaris superioris" RELATED OMO:0003011 [NeuroNames:569] synonym: "superior olivary nuclei" EXACT [FMA:72247] synonym: "superior olivary nucleus" RELATED INCONSISTENT [FMA:72247] synonym: "superior olivary nucleus (Barr & Kiernan)" RELATED [NeuroNames:569] synonym: "superior olive" RELATED INCONSISTENT [FMA:72247, ISBN:0-19-502694-2] xref: BAMS:SOC xref: BIRNLEX:1307 xref: DHBA:12462 xref: EMAPA:35840 xref: EV:0100263 xref: FMA:72247 xref: HBA:9177 xref: MA:0001026 xref: MBA:398 xref: MESH:D065832 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: neuronames:569 {source="BIRNLEX:1307"} xref: UMLS:C0175427 {source="BIRNLEX:1307"} xref: VHOG:0001381 xref: Wikipedia:Superior_olivary_complex is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: part_of UBERON:0003023 {source="NIFSTD"} ! pontine tegmentum relationship: part_of UBERON:0016490 ! auditory system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png xsd:anyURI property_value: RO:0002171 UBERON:0002597 {source="ABA"} property_value: RO:0002171 UBERON:0006840 {source="ABA"} property_value: RO:0002171 UBERON:0007634 {source="ABA"} property_value: UBPROP:0000008 "In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound[GO:0021718]" xsd:string property_value: UBPROP:0000008 "The SOC displays a significant interspecies variation, being largest in bats and rodents and smaller in primates." xsd:string [Term] id: UBERON:0002148 name: locus ceruleus namespace: uberon def: "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." [GAID:577, GO:0021703, Wikipedia:Locus_ceruleus] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blue nucleus" EXACT [BIRNLEX:905] synonym: "caerulean nucleus" EXACT [] synonym: "loci coeruleus" RELATED OMO:0003004 [ZFA:0000539] synonym: "locus caeruleus" EXACT [BIRNLEX:905] synonym: "locus cinereus" RELATED [BTO:0001408] synonym: "locus coeruleu" EXACT [] synonym: "locus coeruleus" EXACT [] synonym: "locus coeruleus (Vicq d'Azyr)" RELATED [NeuroNames:583] synonym: "Noradrenergic cell group A6" EXACT [Noradrenergic_cell_group_A6&oldid=981960774] synonym: "nucleus caeruleus" EXACT OMO:0003011 [FMA:72478, FMA:TA] synonym: "nucleus loci caerulei" RELATED OMO:0003011 [NeuroNames:583] synonym: "nucleus of locus caeruleus" EXACT [] synonym: "nucleus pigmentosus pontis" EXACT [BIRNLEX:905] synonym: "substantia ferruginea" EXACT [BIRNLEX:905] xref: BAMS:CAE xref: BAMS:LC xref: BIRNLEX:905 xref: BM:Pons-LC xref: BTO:0001408 xref: DHBA:12819 xref: DMBA:16972 xref: EFO:0001963 xref: EMAPA:35502 xref: FMA:72478 xref: GAID:577 xref: HBA:9148 xref: MA:0001017 xref: MBA:147 xref: MESH:D008125 xref: NCIT:C97333 xref: neuronames:583 {source="BIRNLEX:905"} xref: SCTID:369016004 xref: TAO:0000539 xref: UMLS:C0023951 {source="ncithesaurus:Locus_Coeruleus", source="BIRNLEX:905"} xref: Wikipedia:Locus_ceruleus xref: ZFA:0000539 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus is_a: UBERON:8440015 ! noradrenergic cell groups relationship: capable_of GO:0048243 ! norepinephrine secretion relationship: part_of UBERON:0003023 {notes="check ZFA", source="NIFSTD"} ! pontine tegmentum property_value: editor_note "TODO - check ZFA/pons. also GO says part of dorsorostral pons" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png xsd:anyURI property_value: RO:0002171 UBERON:0002047 {source="ABA"} property_value: RO:0002171 UBERON:0002267 {source="ABA"} property_value: RO:0002171 UBERON:0002587 {source="ABA"} property_value: RO:0002171 UBERON:0003004 {source="ABA"} [Term] id: UBERON:0002149 name: superior salivatory nucleus namespace: uberon def: "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." [BIRNLEX:1131] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "nucleus salivarius superior" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius cranialis" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius rostralis" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius superior" RELATED OMO:0003011 [NeuroNames:590] synonym: "superior salivary nucleus" EXACT [GO:0021753] xref: BAMS:SSN xref: BAMS:SuS xref: BIRNLEX:1131 xref: DHBA:12435 xref: EHDAA2:0004646 xref: EMAPA:37756 {source="MA:th"} xref: FMA:72482 xref: HBA:9194 xref: MA:0001027 xref: MBA:462 xref: neuronames:590 {source="BIRNLEX:1131"} xref: SCTID:369028007 xref: UMLS:C0175447 {source="BIRNLEX:1131"} xref: Wikipedia:Superior_salivatory_nucleus is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004133 ! salivatory nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata relationship: develops_from UBERON:0001016 ! nervous system relationship: develops_from UBERON:0001017 ! central nervous system relationship: develops_from UBERON:0010125 ! future superior salivatory nucleus relationship: immediate_transformation_of UBERON:0010125 {evidence="definitional"} ! future superior salivatory nucleus relationship: part_of UBERON:0003023 ! pontine tegmentum property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png xsd:anyURI property_value: RO:0002171 UBERON:0002143 {source="ABA"} property_value: RO:0002171 UBERON:0002147 {source="ABA"} property_value: RO:0002171 UBERON:0002151 {source="ABA"} property_value: RO:0002171 UBERON:0002633 {source="ABA"} property_value: RO:0002171 UBERON:0002682 {source="ABA"} property_value: RO:0002171 UBERON:0002963 {source="ABA"} property_value: RO:0002171 UBERON:0002968 {source="ABA"} property_value: RO:0002171 UBERON:0003011 {source="ABA"} property_value: RO:0002171 UBERON:0007632 {source="ABA"} [Term] id: UBERON:0002165 name: endocardium namespace: uberon alt_id: UBERON:0006225 def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." [GO:0003157] comment: fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocardial lining" EXACT [EMAPA:32686] synonym: "endocardial tissue" EXACT [EMAPA:17868] synonym: "heart endocardial tissue" RELATED [VHOG:0000084] synonym: "heart endocardium" EXACT [] xref: AAO:0010408 xref: BTO:0000387 xref: CALOHA:TS-2075 xref: EFO:0000821 xref: EHDAA2:0004153 xref: EMAPA:17868 xref: EMAPA:32686 xref: EV:0100021 xref: FMA:7280 xref: GAID:550 xref: galen:Endocardium xref: MA:0000076 xref: MAT:0000455 xref: MESH:D004699 xref: NCIT:C13004 xref: SCTID:362013006 xref: TAO:0001320 xref: UMLS:C0014124 {source="ncithesaurus:Endocardium"} xref: VHOG:0000084 xref: Wikipedia:Endocardium xref: XAO:0000066 xref: ZFA:0001320 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005983 ! heart layer relationship: develops_from NCBITaxon:6072 ! Eumetazoa relationship: develops_from UBERON:0005498 ! primitive heart tube relationship: develops_from UBERON:0007280 ! presumptive endocardium relationship: has_part UBERON:0005316 ! endocardial endothelium relationship: immediate_transformation_of UBERON:0007280 {source="Bgee:AN"} ! presumptive endocardium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png xsd:anyURI property_value: UBPROP:0000001 "Layer that lines the lumen of the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001320", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010408", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber." xsd:string {source="FMA:7280"} [Term] id: UBERON:0002166 name: endocardium of atrium namespace: uberon def: "Endocardium that is part of the atrium." [ZFIN:curator] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "atrial endocardium" EXACT [] synonym: "atrium endocardial tissue" RELATED [VHOG:0000606] synonym: "atrium endocardium" EXACT [] synonym: "atrium of heart endocardium" EXACT [OBOL:automatic] synonym: "Cardiac atria endocardium" EXACT [OBOL:automatic] synonym: "cardiac atrium endocardium" EXACT [OBOL:automatic] synonym: "endocardium of atrium of heart" EXACT [OBOL:automatic] synonym: "endocardium of Cardiac atria" EXACT [OBOL:automatic] synonym: "endocardium of cardiac atrium" EXACT [OBOL:automatic] synonym: "endocardium of heart atrium" EXACT [OBOL:automatic] synonym: "heart atrium endocardium" EXACT [OBOL:automatic] xref: EMAPA:32745 xref: FMA:7284 xref: MA:0000077 xref: SCTID:192001005 xref: TAO:0002169 xref: VHOG:0000606 xref: ZFA:0001614 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: contributes_to_morphology_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002167 name: right lung namespace: uberon def: "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." [FMA:FMA, Wikipedia:Right_lung] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim xref: EHDAA2:0001730 xref: EHDAA:4969 xref: EMAPA:17661 xref: FMA:7309 xref: MA:0000426 xref: NCIT:C33483 xref: SCTID:361967000 xref: UMLS:C0225706 {source="ncithesaurus:Right_Lung"} xref: VHOG:0000301 xref: Wikipedia:Right_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: in_right_side_of UBERON:0000170 ! pair of lungs relationship: in_right_side_of UBERON:0000170 ! pair of lungs property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb xsd:anyURI property_value: UBPROP:0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000301", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0002168 name: left lung namespace: uberon def: "Lung which consists of the left upper lobe and left lower lobe.[FMA]." [FMA:FMA, Wikipedia:Left_lung] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim xref: EHDAA2:0000943 xref: EHDAA:4947 xref: EMAPA:17653 xref: FMA:7310 xref: MA:0000425 xref: NCIT:C32967 xref: SCTID:361982005 xref: UMLS:C0225730 {source="ncithesaurus:Left_Lung"} xref: VHOG:0000618 xref: Wikipedia:Left_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: in_left_side_of UBERON:0000170 ! pair of lungs relationship: in_left_side_of UBERON:0000170 ! pair of lungs property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb xsd:anyURI property_value: UBPROP:0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000618", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0002185 name: bronchus namespace: uberon def: "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." [ISBN:0-397-51047-0, MESH:A04.411.125, MGI:cwg, MP:0002264] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "bronchi" EXACT OMO:0003004 [] synonym: "bronchial tissue" RELATED [BTO:0001340] synonym: "bronchial trunk" EXACT [FMA:7409] xref: BTO:0001340 xref: CALOHA:TS-1229 xref: EFO:0000932 xref: EMAPA:32689 xref: EV:0100041 xref: FMA:7409 xref: GAID:346 xref: MA:0000436 xref: MAT:0000133 xref: MESH:D001980 xref: MIAA:0000133 xref: NCIT:C12683 xref: SCTID:181215002 xref: UMLS:C0006255 {source="ncithesaurus:Bronchus"} xref: VHOG:0000262 xref: Wikipedia:Bronchus xref: XAO:0000121 is_a: UBERON:0000117 ! respiratory tube relationship: located_in UBERON:0002224 ! thoracic cavity relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb xsd:anyURI property_value: RO:0002161 NCBITaxon:8507 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000262", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "bronchial" xsd:string property_value: UBPROP:0000008 "In humans, the main bronchus is histologically identical to trachea; 2ary and 3ary bronchi are not; epithelium becomes simple columnar, goblet cell number decreases, elastic fibers in lamina propria increases, distribution more uniform. Muscular layer between mucosa and submucosa appears. cartilage rings become discontinuous plates connected by fibrous connective tissue" xsd:string [Term] id: UBERON:0002190 name: subcutaneous adipose tissue namespace: uberon alt_id: UBERON:0008875 def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "fatty layer of subcutaneous tissue" EXACT [FMA:74315] synonym: "fatty layer of superficial fascia" RELATED [FMA:74315] synonym: "hypodermis fat layer" EXACT [MP:0011156] synonym: "panniculus adiposus" BROAD [MP:0011156] synonym: "panniculus adiposus (tela subcutanea)" EXACT OMO:0003011 [FMA:74315, FMA:TA] synonym: "panniculus adiposus telae subcutaneae" EXACT OMO:0003011 [FMA:74315, FMA:TA] synonym: "subcutaneous fat" RELATED [BTO:0004042] synonym: "subcutaneous fat layer" EXACT [MP:0011156] xref: BTO:0004042 xref: EMAPA:35829 xref: FMA:74315 xref: MA:0000473 xref: MESH:D015434 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0002072 ! hypodermis relationship: contributes_to_morphology_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156]" xsd:string {source="MP:0011156"} [Term] id: UBERON:0002193 name: hemolymphoid system namespace: uberon def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "haemolymphoid system" RELATED [] synonym: "hematolymphoid system" EXACT [] synonym: "lymphomyeloid complex" EXACT [] xref: CALOHA:TS-2018 xref: EHDAA2:0004615 xref: EMAPA:18765 xref: FMA:74562 xref: MA:0000013 is_a: UBERON:0000467 {source="MA"} ! anatomical system relationship: in_taxon NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0002199 name: integument namespace: uberon def: "The dermis, epidermis and hypodermis." [Wikipedia:Integument] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dermal system" RELATED [BTO:0000634] synonym: "dermis plus epidermis plus hypodermis" EXACT [] synonym: "dermoid system" RELATED [BTO:0000634] synonym: "integumentum commune" EXACT OMO:0003011 [FMA:74657, FMA:TA] synonym: "skin" RELATED [] synonym: "skin and subcutaneous tissue" EXACT [] synonym: "skin plus hypodermis" EXACT [] synonym: "tegument" RELATED [BTO:0000634] synonym: "the integument" EXACT [FMA:74657] synonym: "vertebrate integument" RELATED [] xref: AAO:0000239 xref: BTO:0000634 xref: EMAPA:37504 {source="MA:th"} xref: FMA:74657 xref: galen:Integument xref: TAO:0000368 xref: VSAO:0000029 xref: Wikipedia:Integument xref: ZFA:0000368 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011216 {source="FMA"} ! organ system subdivision relationship: bounding_layer_of UBERON:0000468 ! multicellular organism relationship: has_part UBERON:0002072 ! hypodermis relationship: has_part UBERON:0002097 ! skin of body relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0002416 {source="FMA"} ! integumental system property_value: IAO:0000232 "in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000239", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Surface structure that is the outer protective covering of the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000029", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000368", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000007 "integumental" xsd:string property_value: UBPROP:0000007 "integumentary" xsd:string [Term] id: UBERON:0002200 name: vasculature of head namespace: uberon def: "Vasculature that is part of a head [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "adult head vascular network" EXACT [OBOL:automatic] synonym: "adult head vasculature" EXACT [OBOL:automatic] synonym: "cranial vasculature" EXACT [] synonym: "head vascular network" EXACT [OBOL:automatic] synonym: "head vasculature" RELATED [] synonym: "vascular network of adult head" EXACT [OBOL:automatic] synonym: "vascular network of head" EXACT [OBOL:automatic] synonym: "vasculature of adult head" EXACT [OBOL:automatic] xref: EFO:0003656 xref: FMA:74710 xref: TAO:0001267 xref: XAO:0004152 xref: ZFA:0001267 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0002201 name: vasculature of trunk namespace: uberon def: "A vasculature that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "torso vascular network" EXACT [OBOL:automatic] synonym: "torso vasculature" EXACT [OBOL:automatic] synonym: "trunk vascular network" EXACT [OBOL:automatic] synonym: "trunk vasculature" EXACT [] synonym: "vascular network of torso" EXACT [OBOL:automatic] synonym: "vascular network of trunk" EXACT [OBOL:automatic] synonym: "vasculature of torso" EXACT [OBOL:automatic] xref: FMA:74712 xref: TAO:0005024 xref: ZFA:0005024 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0002202 name: submucosa of trachea namespace: uberon def: "A submucosa that is part of a trachea." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "submucosa of windpipe" EXACT [OBOL:automatic] synonym: "submucous layer of trachea" RELATED [BTO:0002115] synonym: "trachea submucosa" EXACT [] synonym: "tracheal submucosa" EXACT [] synonym: "windpipe submucosa" EXACT [OBOL:automatic] xref: BTO:0002115 xref: EMAPA:35879 xref: FMA:7472 xref: MA:0001860 xref: NCIT:C49307 xref: SCTID:4419000 xref: UMLS:C0225586 {source="ncithesaurus:Trachea_Submucosa"} is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002203 name: vasculature of eye namespace: uberon def: "Vasculature that is part of the eye region." [https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726, OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "eye vascular network" EXACT [OBOL:automatic] synonym: "eye vasculature" RELATED [] synonym: "ocular blood vessel" EXACT [ZFA:0007057] synonym: "ocular vasculature" EXACT [] synonym: "optic vasculature" RELATED [] synonym: "vascular network of eye" EXACT [OBOL:automatic] xref: FMA:74743 xref: SCTID:123846009 xref: TAO:0007057 xref: ZFA:0007057 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0003314 {source="ISBN:0781772214"} ! eye mesenchyme relationship: part_of UBERON:0000019 ! camera-type eye property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "not part of the eye in ZFA. Note this changed to a blood vessel in ZFA" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0002204 name: musculoskeletal system namespace: uberon def: "Anatomical system that consists of the muscular and skeletal systems." [https://github.com/obophenotype/uberon/issues/77, VSAO:0000031, VSAO:curator] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "musculo-skeletal system" EXACT [] xref: AAO:0010546 xref: CALOHA:TS-1311 xref: EMAPA:32714 xref: EV:0100139 xref: FMA:7482 xref: GAID:98 xref: MA:0002418 xref: MESH:D009141 xref: NCIT:C12754 xref: SCTID:278858007 xref: UMLS:C0026860 {source="ncithesaurus:Musculoskeletal_System"} xref: VHOG:0001275 xref: VSAO:0000031 xref: Wikipedia:Musculoskeletal_system xref: XAO:0000168 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of_part_of GO:0040011 ! locomotion relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_developmental_contribution_from UBERON:0000926 {notes="check ctenophore"} ! mesoderm relationship: has_part UBERON:0000383 ! musculature of body relationship: has_part UBERON:0001434 ! skeletal system property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: UBPROP:0000001 "Anatomical system that provides locomotion and physical support to the organism.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010546", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001275", ontology="VHOG", source="DOI:10.1002/jez.b.21246 Shearman RM, Burke AC, The lateral somitic frontier in ontogeny and phylogeny. Journal of Experimental Zoology (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "musculoskeletal" xsd:string [Term] id: UBERON:0002213 name: cartilaginous joint namespace: uberon def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." [FMA:FMA, Wikipedia:Cartilaginous_joint] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "articulatio cartilaginea" EXACT [] synonym: "junctura cartilaginea" RELATED OMO:0003011 [Wikipedia:Cartilaginous_joint] xref: EMAPA:36581 xref: FMA:7496 xref: MA:0000320 xref: SCTID:58442004 xref: TAO:0005155 xref: Wikipedia:Cartilaginous_joint xref: ZFA:0005155 is_a: UBERON:0011134 {source="FMA"} ! nonsynovial joint intersection_of: UBERON:0011134 ! nonsynovial joint intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: composed_primarily_of UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0002217 name: synovial joint namespace: uberon def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." [FMA:7501, Wikipedia:Synovial_joint] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "articulatio synoviale" EXACT [] synonym: "diarthrodial joints" RELATED OMO:0003004 [ZFA:0005153] synonym: "diarthroses" EXACT OMO:0003004 [ZFA:0005153] synonym: "diarthrosis" EXACT [] synonym: "diarthrosis joint" EXACT [] xref: AEO:0000183 xref: CALOHA:TS-2138 xref: EHDAA2:0003183 xref: FMA:7501 xref: galen:SynovialJoint xref: MA:0000322 xref: NCIT:C32461 xref: SCTID:113234001 xref: TAO:0005153 xref: Wikipedia:Synovial_joint xref: ZFA:0005153 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: surrounded_by UBERON:0001484 ! articular capsule disjoint_from: UBERON:0011134 ! nonsynovial joint relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: surrounded_by UBERON:0001484 ! articular capsule property_value: UBPROP:0000001 "Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005153", ontology="TAO", source="ZFIN:Curator"} [Term] id: UBERON:0002224 name: thoracic cavity namespace: uberon def: "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." [UBERON:cjm, Wikipedia:Thoracic_cavity] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cavitas thoracis" EXACT OMO:0003011 [Wikipedia:Thoracic_cavity] synonym: "cavity of chest" EXACT [] synonym: "cavity of thorax" EXACT [] synonym: "chest cavity" EXACT [] synonym: "pectoral cavity" EXACT [] synonym: "space of thoracic compartment" EXACT [FMA:7565] synonym: "thoracic lumen" EXACT [] xref: EMAPA:36497 xref: FMA:7565 xref: GAID:93 xref: MA:0000032 xref: MESH:D035423 xref: NCIT:C12905 xref: SCTID:243949006 xref: UMLS:C0230139 {source="ncithesaurus:Thoracic_Cavity"} xref: Wikipedia:Thoracic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0002323 ! coelemic cavity lumen property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg xsd:anyURI property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string [Term] id: UBERON:0002240 name: spinal cord namespace: uberon def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." [BIRNLEX:1709] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebro-cerebellar fissure" RELATED [NeuroNames:22] synonym: "cerebrocerebellar fissure" RELATED [NeuroNames:22] synonym: "fissura cerebro-cerebellaris" RELATED OMO:0003011 [NeuroNames:22] synonym: "fissura cerebrocerebellaris" RELATED OMO:0003011 [NeuroNames:22] synonym: "medulla spinalis" RELATED OMO:0003011 [BTO:0001279, Wikipedia:Spinal_cord] synonym: "SpC" RELATED OMO:0003000 [] synonym: "spinal cord structure" RELATED [ZFA:0000075] synonym: "spinal medulla" RELATED [BTO:0001279] xref: AAO:0010151 xref: BAMS:SP xref: BAMS:Spinal xref: BIRNLEX:1709 xref: BM:SpC xref: BTO:0001279 xref: CALOHA:TS-0953 xref: DHBA:12890 xref: DMBA:17651 xref: EFO:0000110 xref: EHDAA2:0001255 xref: EHDAA:2863 xref: EMAPA:17577 xref: EV:0100316 xref: FMA:7647 xref: GAID:695 xref: MA:0000216 xref: MAT:0000183 xref: MESH:D013116 xref: MIAA:0000183 xref: NCIT:C12464 xref: neuronames:22 {source="BIRNLEX:1709"} xref: SCTID:180959008 xref: TAO:0000075 xref: UMLS:C0037925 {source="ncithesaurus:Spinal_Cord", source="BIRNLEX:1709"} xref: VHOG:0000601 xref: Wikipedia:Spinal_cord xref: XAO:0000020 xref: ZFA:0000075 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0001016 ! nervous system relationship: develops_from UBERON:0001017 ! central nervous system relationship: develops_from UBERON:0003076 ! posterior neural tube relationship: develops_from UBERON:0006241 ! future spinal cord relationship: has_developmental_contribution_from UBERON:0003853 {evidence="definitional"} ! spinal cord neural crest relationship: has_part CL:0005000 {source="ZFA"} ! spinal cord interneuron relationship: immediate_transformation_of UBERON:0006241 {evidence="definitional"} ! future spinal cord relationship: part_of UBERON:0001017 ! central nervous system property_value: editor_note "TODO - add superclass to unify with VNC?" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/spinal-cord-female/v1.1/assets/3d-vh-f-spinal-cord.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/spinal-cord-male/v1.1/assets/3d-vh-m-spinal-cord.glb xsd:anyURI property_value: RO:0002171 UBERON:0000955 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010151", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000601", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002241 name: chondrocranium namespace: uberon def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." [http://medical-dictionary.thefreedictionary.com/chondrocranium, Wikipedia:Chondrocranium] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "calvarium" RELATED [MA:0000317] synonym: "neurocranium" RELATED INCONSISTENT [MA:0000317] xref: AAO:0010169 xref: EHDAA2:0000243 xref: EMAPA:17681 xref: TAO:0001424 xref: VHOG:0000288 xref: Wikipedia:Chondrocranium xref: ZFA:0001424 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: overlaps UBERON:0001703 ! neurocranium property_value: editor_note "we follow the standard evolutionary classification and treat this as endoskeletal. This means what MA calls 'chondrocranium' must in fact be neurocranium, as it includes parts of the dermatocranium (e.g. frontal, parietal)" xsd:string property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010169", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001424", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000007 "chondrocranial" xsd:string property_value: UBPROP:0000008 "covers the brain dorsally in chondrichthyans" xsd:string [Term] id: UBERON:0002257 name: ventral horn of spinal cord namespace: uberon def: "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." [GO:0021517, https://sourceforge.net/tracker/?group_id=36855&atid=440764, MP:0005112, Wikipedia:Anterior_horn_of_spinal_cord] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "anterior column" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "anterior column of the spinal cord" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "anterior gray column of spinal cord" EXACT [FMA:256541] synonym: "anterior gray horn of spinal cord" EXACT [FMA:256541] synonym: "anterior grey column of spinal cord" EXACT [] synonym: "anterior horn" EXACT [BIRNLEX:2668] synonym: "anterior horn (spinal cord)" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "columna grisea anterior medullae spinalis" EXACT OMO:0003011 [FMA:256541, FMA:TA] synonym: "cornu anterius medullae spinalis" RELATED OMO:0003011 [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "spinal cord anterior horn" EXACT [BIRNLEX:2668] synonym: "spinal cord ventral horn" EXACT [] synonym: "ventral gray column of spinal cord" EXACT [FMA:256541] synonym: "ventral gray matter of spinal cord" EXACT [FMA:256541] synonym: "ventral grey column of spinal cord" EXACT [] synonym: "ventral grey horn" EXACT [BIRNLEX:2668] synonym: "ventral horn of the spinal cord" RELATED [BAMS:VH] synonym: "ventral horn spinal cord" EXACT [ZFA:0000702] synonym: "ventral horns spinal cord" RELATED OMO:0003004 [VHOG:0001288] synonym: "ventral region of spinal cord" EXACT [] synonym: "ventral spinal cord" EXACT [] xref: BAMS:VH xref: BIRNLEX:2668 xref: BTO:0005151 xref: EMAPA:18575 xref: EMAPA:35794 xref: FMA:256541 xref: MA:0001134 xref: NCIT:C33859 xref: neuronames:1751 xref: SCTID:279443000 xref: TAO:0000702 xref: UMLS:C0228569 {source="BIRNLEX:2668"} xref: UMLS:C0228590 {source="ncithesaurus:Ventral_Horn_of_the_Spinal_Cord"} xref: VHOG:0001288 xref: Wikipedia:Anterior_horn_of_spinal_cord xref: ZFA:0000702 is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0016550 ! spinal cord column relationship: contributes_to_morphology_of UBERON:0002315 ! gray matter of spinal cord relationship: has_part CL:0000100 ! motor neuron relationship: in_lateral_side_of UBERON:0002315 {source="FMA-abduced-lr"} ! gray matter of spinal cord relationship: part_of UBERON:0002315 ! gray matter of spinal cord property_value: UBPROP:0000001 "The anterior horn of the spinal cord (or anterior cornu, or anterior column, or ventral horn) is the ventral (front) grey matter section of the spinal cord. The anterior horn contains motor neurons that affect the axial muscles while the posterior horn receives information regarding touch and sensation. The anterior horn is where the cell bodies of alpha motorneurons are located[Wikipedia:Anterior_horn_of_spinal_cord]." xsd:string {source="Wikipedia:Anterior_horn_of_spinal_cord"} [Term] id: UBERON:0002275 name: reticular formation namespace: uberon def: "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." [NeuroNames:1223] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "brain stem reticular formation" EXACT [NeuroNames:1223] synonym: "brainstem reticular formation" EXACT [MA:0003185, NeuroNames:1223] synonym: "reticular formation (classical)" EXACT [NeuroNames:1223] synonym: "reticular formation of the brainstem" EXACT [NeuroNames:1223] xref: BAMS:RET xref: EMAPA:35188 xref: FMA:77719 xref: MA:0003185 xref: MESH:D012154 xref: neuronames:1223 xref: NLX:143558 xref: SCTID:361552007 xref: Wikipedia:Reticular_formation is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0002298 ! brainstem property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png xsd:anyURI property_value: IAO:0000232 "this class denotes the generic structure, and not a specific one such as medullary or pontine reticular formation." xsd:string property_value: UBPROP:0000008 "It is essential for governing some of the basic functions of higher organisms, and is one of the phylogenetically oldest portions of the brain." xsd:string property_value: UBPROP:0000012 "FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002294 name: biliary system namespace: uberon def: "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." [Wikipedia:Biliary_system] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "biliary apparatus" EXACT [FMA:79646] synonym: "biliary tract" RELATED [FMA:79646, MA:0001273] xref: FMA:79646 xref: GAID:279 xref: MA:0001273 xref: MESH:D001659 xref: NCIT:C12678 xref: SCTID:361354009 xref: Wikipedia:Biliary_system is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: capable_of GO:0006699 ! bile acid biosynthetic process intersection_of: capable_of GO:0015721 ! bile acid and bile salt transport intersection_of: has_part UBERON:0001173 ! biliary tree disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0006699 ! bile acid biosynthetic process relationship: capable_of GO:0015721 ! bile acid and bile salt transport relationship: has_part UBERON:0001173 ! biliary tree relationship: part_of UBERON:0002423 ! hepatobiliary system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI property_value: RO:0002171 UBERON:0016478 [Term] id: UBERON:0002298 name: brainstem namespace: uberon def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." [ISBN:0471888893, MP:0005277, Wikipedia:Brainstem, ZFA:0001707] comment: 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "accessory medullary lamina of pallidum" RELATED [NeuroNames:236] synonym: "brain stem" EXACT [ABA:BS] synonym: "lamella pallidi incompleta" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina medullaris accessoria" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina medullaris incompleta pallidi" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina pallidi incompleta" RELATED OMO:0003011 [NeuroNames:236] synonym: "truncus encephali" EXACT OMO:0003011 [Wikipedia:Brainstem] synonym: "truncus encephalicus" RELATED OMO:0003011 [BTO:0000146] xref: BAMS:BS xref: BIRNLEX:1565 xref: BTO:0000146 xref: CALOHA:TS-0093 xref: EFO:0001962 xref: EMAPA:32678 xref: EV:0100241 xref: FMA:79876 xref: MA:0000169 xref: MBA:343 xref: MESH:D001933 xref: NCIT:C12441 xref: neuronames:236 {source="BIRNLEX:1565"} xref: SCTID:180925009 xref: TAO:0002156 xref: UMLS:C0006121 {source="BIRNLEX:1565", source="ncithesaurus:Brain_Stem"} xref: VHOG:0001457 xref: Wikipedia:Brainstem xref: ZFA:0001707 is_a: UBERON:0002616 ! regional part of brain relationship: continuous_with UBERON:0002240 ! spinal cord relationship: contributes_to_morphology_of UBERON:0000955 ! brain relationship: has_part UBERON:0001896 ! medulla oblongata relationship: has_part UBERON:0001943 ! midbrain tegmentum property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png xsd:anyURI property_value: RO:0002171 UBERON:0001890 {notes="we apply a strict definition"} property_value: RO:0002171 UBERON:0002037 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} property_value: RO:0002171 UBERON:0002314 {notes="we apply a strict definition"} property_value: UBPROP:0000001 "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002156", ontology="TAO", source="ISBN:3764351209"} property_value: UBPROP:0000001 "Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]." xsd:string {source="ZFA:0001707"} property_value: UBPROP:0000001 "the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP]" xsd:string {source="MP:0005277"} [Term] id: UBERON:0002302 name: myocardium of atrium namespace: uberon def: "The atrial part of middle layer of the heart, comprised of involuntary muscle." [ISBN:0-683-40008-8, MP:0010493] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "atrial myocardium" EXACT [ZFA:0001374] synonym: "atrium cardiac muscle" RELATED [VHOG:0000602] synonym: "atrium myocardium" EXACT [] xref: EFO:0003087 xref: EMAPA:32746 xref: FMA:83509 xref: MA:0000081 xref: SCTID:191910002 xref: TAO:0001374 xref: VHOG:0000602 xref: ZFA:0001374 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: contributes_to_morphology_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium property_value: UBPROP:0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000602", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002308 name: nucleus of brain namespace: uberon def: "A neural nucleus that is part of the brain." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "brain nuclei" RELATED OMO:0003004 [ZFA:0005575] synonym: "brain nucleus" EXACT [] xref: EMAPA:35185 xref: FMA:83840 xref: MA:0000811 xref: NCIT:C49346 xref: SCTID:426465002 xref: UMLS:C1706993 {source="ncithesaurus:Brain_Nucleus"} xref: ZFA:0005575 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0003528 ! brain gray matter [Term] id: UBERON:0002315 name: gray matter of spinal cord namespace: uberon def: "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." [MP:0008503] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "gray matter of spinal cord" EXACT [OBOL:automatic] synonym: "gray substance of spinal cord" EXACT [FMA:256580] synonym: "grey matter of spinal cord" EXACT [] synonym: "grey substance of spinal cord" EXACT [] synonym: "spinal cord gray matter" EXACT [OBOL:automatic] synonym: "spinal cord grey matter" EXACT [] synonym: "spinal cord grey substance" EXACT [OBOL:automatic] synonym: "substantia grisea medullae spinalis" EXACT OMO:0003011 [FMA:256580, FMA:TA] xref: BAMS:Scgrey xref: DHBA:146035048 xref: EMAPA:35792 xref: FMA:256580 xref: MA:0000002 xref: NCIT:C32696 xref: neuronames:2619 xref: NLXANAT:100204 xref: SCTID:279441003 xref: UMLS:C0475853 {source="ncithesaurus:Gray_Matter_of_the_Spinal_Cord"} is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0002240 ! spinal cord relationship: contributes_to_morphology_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0002323 name: coelemic cavity lumen namespace: uberon alt_id: UBERON:0000169 def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." [BTO:0001707] comment: EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "body cavity" BROAD [BTO:0001707] synonym: "celom" RELATED [BTO:0001707] synonym: "coelom" RELATED [] synonym: "coelome" RELATED [BTO:0001707] synonym: "coelomic cavity" EXACT [EHDAA2:0000267] synonym: "coelomic cavity lumen" EXACT [EHDAA2:0000267] synonym: "hemocoel" RELATED [FBbt:00005060] synonym: "main body cavity" EXACT [] synonym: "space of body compartment" EXACT [FMA:85006] synonym: "ventral body cavity" NARROW [NCBITaxon:7742] xref: AEO:0000186 xref: BTO:0001707 xref: EHDAA2:0000267 xref: FBbt:00005060 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:85006 xref: galen:BodyCavity xref: NCIT:C25444 xref: RETIRED_EHDAA2:0003186 xref: SCTID:361348008 xref: TAO:0001438 xref: UMLS:C0333343 {source="ncithesaurus:Cavity"} is_a: UBERON:0002553 ! anatomical cavity relationship: develops_from UBERON:0003886 ! future coelemic cavity lumen relationship: luminal_space_of UBERON:0011997 ! coelom relationship: part_of UBERON:0011997 ! coelom relationship: transformation_of UBERON:0003886 {evidence="definitional"} ! future coelemic cavity lumen property_value: UBPROP:0000001 "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]." xsd:string {date_retrieved="2012-09-12", external_class="BTO:0001707", ontology="BTO", source="BTO"} property_value: UBPROP:0000008 "In mammals it forms the peritoneal, pleural, and pericardial cavities" xsd:string [Term] id: UBERON:0002324 name: muscle of back namespace: uberon def: "Any muscle organ that is part of a back [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "back muscle" EXACT [] synonym: "back muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of back" EXACT [OBOL:automatic] xref: EMAPA:35161 xref: FMA:85216 xref: MA:0000496 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0004469 {source="prolog"} ! musculature of back property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002328 name: notochord namespace: uberon def: "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." [http://tolweb.org/Chordata/2499, https://github.com/obophenotype/uberon/issues/25, https://github.com/obophenotype/uberon/issues/271, ISBN:0815318960, Wikipedia:Notochord] comment: The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic notocord" EXACT [] synonym: "notochorda" RELATED OMO:0003011 [Wikipedia:Notochord] synonym: "notocord" EXACT [ZFA:0000135] xref: AAO:0000327 xref: BTO:0001768 xref: CALOHA:TS-0690 xref: EHDAA2:0001277 xref: EHDAA:1241 xref: EHDAA:6021 xref: EMAPA:16191 xref: EV:0100002 xref: FMA:85521 xref: GAID:1311 xref: http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg xref: MAT:0000281 xref: MESH:D009672 xref: NCIT:C12463 xref: SCTID:308820002 xref: TAO:0000135 xref: UMLS:C0028439 {source="ncithesaurus:Notochord"} xref: VHOG:0000199 xref: VSAO:0000032 xref: Wikipedia:Notochord xref: XAO:0000055 xref: ZFA:0000135 is_a: UBERON:0000062 {source="PMID:15890825"} ! organ is_a: UBERON:0000481 {source="VSAO"} ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0004880 {source="ZFA"} ! chordamesoderm relationship: develops_from UBERON:0006267 {source="EHDAA2"} ! notochordal plate relationship: dorsal_to UBERON:0001555 ! digestive tract relationship: existence_starts_during UBERON:0000068 ! embryo stage relationship: in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2499"} ! Chordata relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000922 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! embryo relationship: part_of UBERON:0011137 ! axial skeletal system relationship: produces PR:000014841 ! sonic hedgehog protein relationship: ventral_to UBERON:0001049 ! neural tube property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/wdahdul property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000199", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "notochordal" xsd:string property_value: UBPROP:0000011 "In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord." xsd:string [Term] id: UBERON:0002329 name: somite namespace: uberon def: "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." [DOI:10.1111/j.1439-0426.2012.01987.x, Wikipedia:Somite] comment: When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epimere" RELATED [ISBN:0073040584] synonym: "epimere mesoderm" RELATED [] synonym: "epithelial somite" RELATED [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "mesodermal cluster" BROAD [GO:0001756] synonym: "somites" RELATED OMO:0003004 [] synonym: "somitic mesoderm" RELATED [] synonym: "somitus" RELATED OMO:0003011 [Wikipedia:Somite] xref: AAO:0010569 xref: AEO:0001015 xref: BTO:0001558 xref: EHDAA2:0003436 xref: EHDAA:366 xref: EHDAA:699 xref: EMAPA:31169 xref: FMA:85522 xref: GAID:1306 xref: MAT:0000068 xref: MESH:D019170 xref: MIAA:0000068 xref: NCIT:C34302 xref: TAO:0000155 xref: UMLS:C0376449 {source="ncithesaurus:Somite"} xref: VHOG:0000191 xref: Wikipedia:Somite xref: XAO:0000058 xref: ZFA:0000155 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm relationship: in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: IAO:0000232 "EDITOR_NOTE currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string property_value: RO:0002161 NCBITaxon:7712 {source="PMID:17237766"} property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO"} property_value: UBPROP:0000002 "relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO"} property_value: UBPROP:0000002 "relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO"} property_value: UBPROP:0000003 "(...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000191", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.40, DOI:10.1093/icb/43.1.137 Balavoine G, Adoutte A, The segmented urbilateria: a testable scenario. Integrative and Comparative Biology (2003)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "somitic" xsd:string [Term] id: UBERON:0002330 name: exocrine system namespace: uberon def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." [Wikipedia:Exocrine_gland] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "exocrine glandular system" EXACT [EHDAA2:0002225] xref: CALOHA:TS-2057 xref: EHDAA2:0002225 xref: EMAPA:35329 xref: FMA:85539 xref: MA:0002411 xref: NCIT:C12957 xref: UMLS:C1516995 {source="ncithesaurus:Exocrine_System"} xref: Wikipedia:Exocrine_gland xref: WikipediaCategory:Exocrine_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: composed_primarily_of UBERON:0002365 ! exocrine gland relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002333 name: pulmonary trunk namespace: uberon def: "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "main pulmonary artery" RELATED [Wikipedia:Pulmonary_artery] synonym: "pulmonary artery (trunk)" EXACT [] synonym: "trunk of pulmonary arterial tree" EXACT [] xref: EHDAA2:0001576 xref: EHDAA:9831 xref: EMAPA:17015 xref: FMA:8612 xref: galen:PulmonaryTrunk xref: MA:0002033 xref: NCIT:C116918 xref: VHOG:0001134 is_a: UBERON:0001637 {source="MA"} ! artery relationship: connected_to UBERON:0002080 ! heart right ventricle relationship: continuous_with UBERON:0000948 ! heart relationship: continuous_with UBERON:0002080 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! heart right ventricle relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0008886 ! pulmonary vascular system property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001134", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+trunk"} property_value: UBPROP:0000003 "As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001134", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002338 name: lamina propria of bronchus namespace: uberon def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bronchi lamina propria" EXACT [OBOL:automatic] synonym: "bronchi lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchi lamina propria mucosae" EXACT [OBOL:automatic] synonym: "bronchial lamina propria" RELATED [EMAPA:35194] synonym: "bronchial trunk lamina propria" EXACT [OBOL:automatic] synonym: "bronchial trunk lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk lamina propria mucosae" EXACT [OBOL:automatic] synonym: "bronchus lamina propria" EXACT [] synonym: "bronchus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchus lamina propria mucosae" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchus" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchial trunk" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchus" EXACT [OBOL:automatic] synonym: "lamina propria of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria of bronchial trunk" EXACT [OBOL:automatic] xref: EMAPA:35194 xref: FMA:86619 xref: MA:0001836 xref: NCIT:C49212 xref: UMLS:C1707054 {source="ncithesaurus:Bronchus_Lamina_Propria"} is_a: UBERON:0000031 ! lamina propria of trachea intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0000410 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! bronchial mucosa [Term] id: UBERON:0002342 name: neural crest namespace: uberon def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." [MP:0009846] comment: Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "crista neuralis" RELATED OMO:0003011 [Wikipedia:Neural_crest] synonym: "NC" EXACT OMO:0003000 [XAO:0000048] synonym: "neural crest material" RELATED [VHOG:0000057] xref: AAO:0010578 xref: BTO:0001764 xref: CALOHA:TS-0676 xref: EHDAA2:0004419 xref: EMAPA:32737 xref: FMA:86666 xref: GAID:1310 xref: MAT:0000066 xref: MESH:D009432 xref: MIAA:0000066 xref: NCIT:C34222 xref: neuronames:1366 xref: SCTID:361462002 xref: UMLS:C0027789 {source="ncithesaurus:Neural_Crest"} xref: VHOG:0000057 xref: Wikipedia:Neural_crest xref: XAO:0000048 xref: ZFA:0000045 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010316 ! germ layer / neural crest relationship: composed_primarily_of CL:0000333 {notes="pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! migratory neural crest cell relationship: develops_from UBERON:0003075 {source="BTO"} ! neural plate relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fold relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage relationship: in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png xsd:anyURI property_value: IAO:0000232 "EDITOR_NOTE consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"} property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010578", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831]" xsd:string {source="PMID:11523831"} property_value: UBPROP:0000003 "We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000057", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002343 name: abdomen musculature namespace: uberon def: "Set of all muscles in abdomen." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "abdominal musculature" EXACT [] synonym: "muscle group of abdomen" EXACT [FMA:71294] synonym: "muscles of abdomen" EXACT [FMA:71294] synonym: "musculature of abdomen" EXACT [] synonym: "musculature of abdominal wall" EXACT [FMA:86917] synonym: "set of muscles of abdomen" EXACT [FMA:71294] xref: FMA:71294 xref: FMA:86917 xref: TAO:0001327 xref: ZFA:0001327 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen property_value: IAO:0000232 "distinction between abdomen muscle and abdomen musculature" xsd:string [Term] id: UBERON:0002345 name: descending thoracic aorta namespace: uberon def: "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [MP:0009868] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim xref: EFO:0002527 xref: EMAPA:18605 xref: FMA:87217 xref: MA:0002572 xref: SCTID:181301002 is_a: UBERON:0013522 ! subdivision of tube relationship: contributes_to_morphology_of UBERON:0001514 ! descending aorta relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: part_of UBERON:0001514 ! descending aorta relationship: part_of UBERON:0001515 ! thoracic aorta property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002346 name: neurectoderm namespace: uberon def: "Embryonic ectoderm that gives rise to nervous tissue." [Wikipedia:Neuroectoderm] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "epithelium tubi neuralis; neuroectoderma" RELATED OMO:0003011 [Wikipedia:Neuroectoderm] synonym: "neuaral ectoderm" RELATED [] synonym: "neural ectoderm" EXACT [] synonym: "neuroectoderm" EXACT [] synonym: "presumptive central nervous system" RELATED [] synonym: "ventral neurogenic region" RELATED [VHOG:0000150] xref: AAO:0011074 xref: BILA:0000039 xref: CALOHA:TS-1212 xref: EHDAA2:0001248 xref: EHDAA:1498 xref: EHDAA:255 xref: EMAPA:16073 xref: EV:0100004 xref: FBbt:00001057 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:87657 xref: MAT:0000176 xref: MIAA:0000176 xref: NCIT:C34228 xref: TAO:0001120 xref: UMLS:C1518271 {source="ncithesaurus:Neuroectoderm"} xref: VHOG:0000150 xref: Wikipedia:Neuroectoderm xref: XAO:0000042 xref: ZFA:0001120 is_a: UBERON:0000923 ! germ layer is_a: UBERON:0004121 ! ectoderm-derived structure relationship: has_part CL:0000133 ! neurectodermal cell property_value: UBPROP:0000003 "(...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000150", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "neurectodermal" xsd:string property_value: UBPROP:0000013 "we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here" xsd:string [Term] id: UBERON:0002347 name: thoracic vertebra namespace: uberon def: "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "dorsal vertebra" EXACT [] synonym: "thorax vertebra" EXACT [OBOL:automatic] synonym: "vertebra of thorax" EXACT [OBOL:automatic] synonym: "vertebra thoracica" EXACT [] xref: EMAPA:18011 xref: FMA:9139 xref: GAID:244 xref: MA:0000314 xref: MESH:D013904 xref: NCIT:C12798 xref: SCTID:181821009 xref: UMLS:C0039987 {source="ncithesaurus:Thoracic_Vertebra"} xref: Wikipedia:Thoracic_vertebrae is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0013507 ! thoracic vertebra cartilage element property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, they are distinguished by the presence of facets on the sides of the bodies for articulation with the heads of the ribs, and facets on the transverse processes of all, except the eleventh and twelfth, for articulation with the tubercles of the ribs" xsd:string [Term] id: UBERON:0002348 name: epicardium namespace: uberon def: "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] comment: EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "heart epicardium" EXACT [] synonym: "pericardium visceral mesothelium" RELATED [EMAPA:16589] synonym: "visceral serous pericardium of heart" EXACT [FMA:9461] synonym: "visceral serous pericardium proper" EXACT [FMA:9461] xref: AAO:0010409 xref: EHDAA2:0002202 xref: FMA:9461 xref: galen:Epicardium xref: NCIT:C13164 xref: TAO:0005057 xref: UMLS:C0225968 {source="ncithesaurus:Epicardium"} xref: VHOG:0000119 xref: Wikipedia:Epicardium xref: XAO:0000316 xref: ZFA:0005057 is_a: UBERON:0000481 ! multi-tissue structure relationship: attaches_to UBERON:0002349 {source="FMA"} ! myocardium relationship: develops_from UBERON:0004160 ! proepicardium relationship: part_of UBERON:0000948 {source="multiple"} ! heart relationship: part_of UBERON:0002425 {source="FMA-inferred"} ! visceral serous pericardium property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "External layer of the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005057", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The inner layer of the pericardium that is in contact with the surface of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010409", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000009 "The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium]" xsd:string [Term] id: UBERON:0002349 name: myocardium namespace: uberon def: "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." [ISBN:0-683-40008-8, MP:0005329] comment: EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac muscle" RELATED [ZFA:0001319] synonym: "heart muscle" RELATED [FMA:9462, ZFA:0001319] synonym: "heart myocardium" EXACT [] synonym: "muscle of heart" EXACT [FMA:9462] xref: AAO:0010410 xref: BSA:0000089 xref: BTO:0000901 xref: CALOHA:TS-0440 xref: EFO:0000819 xref: EHDAA2:0004150 xref: EV:0100022 xref: FMA:9462 xref: GAID:173 xref: galen:Myocardium xref: MA:0000164 xref: MAT:0000453 xref: MESH:D009206 xref: NCIT:C12371 xref: RETIRED_EHDAA2:0001220 xref: SCTID:362012001 xref: TAO:0001319 xref: UMLS:C0027061 {source="ncithesaurus:Myocardium"} xref: VHOG:0000083 xref: Wikipedia:Myocardium xref: XAO:0000065 xref: ZFA:0001319 is_a: UBERON:0005983 ! heart layer is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0005983 ! heart layer intersection_of: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue relationship: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue relationship: has_part UBERON:0002350 ! conducting system of heart relationship: part_of UBERON:0000383 ! musculature of body property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg xsd:anyURI property_value: UBPROP:0000001 "Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000083", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "The middle layer of the heart, consisting of cardiac muscle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010410", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000007 "myocardial" xsd:string [Term] id: UBERON:0002350 name: conducting system of heart namespace: uberon def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." [GO:0003161] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "cardiac conducting system" EXACT [VHOG:0001271] synonym: "cardiac conduction system" EXACT [] synonym: "cardiac impulse conducting system" EXACT [GO:0003161] synonym: "cardionector" EXACT [] synonym: "central conduction system" RELATED [] synonym: "complexus stimulans cordis" EXACT OMO:0003011 [FMA:9476, FMA:TA] synonym: "heart conduction system" EXACT [GO:0003161] synonym: "impulse conducting system" EXACT [MA:0000094] synonym: "systema conducente cordis" EXACT OMO:0003011 [FMA:9476, FMA:TA] xref: EFO:0003909 xref: EHDAA2:0004185 xref: EMAPA:35428 xref: EV:0100025 xref: FMA:9476 xref: MA:0000094 xref: MESH:D006329 xref: SCTID:281489000 xref: TAO:0005063 xref: VHOG:0001271 xref: ZFA:0005063 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 {source="FMA"} ! conducting tissue of heart relationship: contributes_to_morphology_of UBERON:0000948 ! heart relationship: has_part CL:0002068 {source="FMA"} ! Purkinje myocyte relationship: has_part CL:0002073 {source="FMA"} ! transitional myocyte relationship: has_part CL:0002074 {source="FMA"} ! myocardial endocrine cell relationship: has_part CL:1000409 {source="FMA"} ! myocyte of sinoatrial node relationship: has_part CL:1000410 {source="FMA"} ! myocyte of atrioventricular node property_value: editor_note "EHDAA2 divides the system from the tissue" xsd:string property_value: UBPROP:0000003 "The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001271", ontology="VHOG", source="DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002351 name: sinoatrial node namespace: uberon def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [GO:0003163, Wikipedia:Sinoatrial_node] comment: WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac pacemaker" EXACT [FMA:9477] synonym: "Koch's node" EXACT [FMA:9477] synonym: "node of Keith-Flack" EXACT [FMA:9477] synonym: "nodus sinuatrialis" EXACT OMO:0003011 [FMA:9477, FMA:TA] synonym: "nodus sinuatrialis" RELATED OMO:0003011 [Wikipedia:Sinoatrial_node] synonym: "SA nodal muscle tissue" EXACT [FMA:9477] synonym: "SA node" EXACT [FMA:9477] synonym: "sinoatrial node" EXACT [FMA:9477] synonym: "sinu-atrial node" EXACT [FMA:9477] synonym: "sinuatrial nodal muscle tissue" EXACT [FMA:9477] synonym: "sinuatrial node" EXACT [FMA:9477] synonym: "sinus node" EXACT [FMA:9477] synonym: "sinus node of Keith and Flack" EXACT [FMA:9477] xref: BTO:0004358 xref: EHDAA2:0004184 xref: EMAPA:35772 xref: FMA:9477 xref: GAID:561 xref: MA:0000097 xref: MESH:D012849 xref: NCIT:C33555 xref: SCTID:277687007 xref: TAO:0005069 xref: UMLS:C0037189 {source="ncithesaurus:Sinoatrial_Node"} xref: Wikipedia:Sinoatrial_node xref: ZFA:0005069 is_a: UBERON:0003379 ! cardiac muscle of right atrium is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: capable_of GO:0002027 ! regulation of heart rate relationship: capable_of_part_of GO:0060048 ! cardiac muscle contraction relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002350 {source="ZFA"} ! conducting system of heart property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002352 name: atrioventricular node namespace: uberon def: "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." [UBERON:cjm, Wikipedia:Atrioventricular_node] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "A-V node" RELATED [EMAPA:35153] synonym: "Aschoff-Tawara node" EXACT [FMA:9478] synonym: "atrio-ventricular node" RELATED [EMAPA:35153] synonym: "atrioventricular nodal muscle tissue" EXACT [FMA:9478] synonym: "atriovetricular node" RELATED [TAO:0005070] synonym: "AV nodal muscle tissue" EXACT [FMA:9478] synonym: "AV node" EXACT [FMA:9478, MA:0000095] synonym: "downstream pacemaker" RELATED [ZFA:0005070] synonym: "node of Tawara" EXACT [FMA:9478] synonym: "nodus atrioventricularis" EXACT OMO:0003011 [FMA:TA] synonym: "nodus atrioventricularis" RELATED OMO:0003011 [Wikipedia:Atrioventricular_node] xref: BTO:0005689 xref: EFO:0000276 xref: EHDAA2:0004183 xref: EMAPA:35153 xref: FMA:9478 xref: GAID:558 xref: MA:0000095 xref: MAT:0000498 xref: MESH:D001283 xref: NCIT:C32161 xref: SCTID:277688002 xref: TAO:0005070 xref: UMLS:C0004247 {source="ncithesaurus:Atrioventricular_Node"} xref: VHOG:0001474 xref: Wikipedia:Atrioventricular_node xref: ZFA:0005070 is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: connected_to UBERON:0002085 ! interatrial septum relationship: connected_to UBERON:0005979 ! crista terminalis relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0002350 ! conducting system of heart property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001474", ontology="VHOG", source="DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002354 name: cardiac Purkinje fiber namespace: uberon alt_id: UBERON:0004147 def: "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GO:0003165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cardiac Purkinje fiber" EXACT [BTO:0001735, GO:0003165] synonym: "heart Purkinje fiber" RELATED [BTO:0001735] synonym: "myofibra conducens cardiacus" EXACT OMO:0003011 [] synonym: "Purkinje fiber" EXACT [FMA:9492, MA:0000096] synonym: "subendocardial branch" EXACT [Wikipedia:Purkinje_fiber] xref: BTO:0001735 xref: EMAPA:35718 xref: FMA:9492 xref: GAID:560 xref: MA:0000096 xref: MESH:D011690 xref: NCIT:C33430 xref: UMLS:C0034144 {source="ncithesaurus:Purkinje_Fiber"} xref: Wikipedia:Purkinje_fiber is_a: UBERON:0010131 {source="FMA"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart relationship: has_part CL:0002068 {source="FMA"} ! Purkinje myocyte relationship: part_of UBERON:8000009 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! Purkinje fiber network property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png xsd:anyURI [Term] id: UBERON:0002357 name: serous pericardium namespace: uberon def: "Serous membrane which is divided into parietal and visceral serous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Serous_pericardium] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "pericardium serosum" RELATED OMO:0003011 [Wikipedia:Serous_pericardium] synonym: "serous portion of pericardium" EXACT [FMA:9582] xref: EMAPA:19030 xref: FMA:9582 xref: MA:0002739 xref: SCTID:243954002 xref: Wikipedia:Serous_pericardium is_a: UBERON:0000042 ! serous membrane relationship: attaches_to UBERON:0002359 {source="FMA"} ! fibrous pericardium relationship: has_part UBERON:0002408 ! parietal serous pericardium relationship: has_part UBERON:0002425 ! visceral serous pericardium relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0002406 {source="FMA"} ! pericardial sac [Term] id: UBERON:0002358 name: peritoneum namespace: uberon def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." [VHOG:0001257] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "peritonaeum" RELATED [VHOG:0001257] xref: AAO:0010814 xref: BTO:0001472 xref: CALOHA:TS-2072 xref: EV:0100087 xref: FMA:9584 xref: GAID:18 xref: galen:Peritoneum xref: MA:0000449 xref: MESH:D010537 xref: NCIT:C12770 xref: TAO:0005120 xref: UMLS:C0031153 {source="ncithesaurus:Peritoneum"} xref: VHOG:0001257 xref: Wikipedia:Peritoneum xref: XAO:0000139 xref: ZFA:0005120 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0035820 ! peritoneal sac relationship: part_of UBERON:0003697 {source="MP"} ! abdominal wall relationship: part_of UBERON:0035820 ! peritoneal sac property_value: editor_note "TODO - in ZFA is_a epithelium" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png xsd:anyURI property_value: UBPROP:0000001 "An epithelium that lines the peritoneal cavity.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005120", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010814", ontology="AAO", source="AAO:JMG"} property_value: UBPROP:0000007 "peritoneal" xsd:string property_value: UBPROP:0000012 "todo: check MA/EMAPA." xsd:string {external_ontology="MA"} [Term] id: UBERON:0002359 name: fibrous pericardium namespace: uberon def: "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." [FMA:9586] subset: human_subset subset: mouse_subset subset: organ_slim subset: uberon_slim synonym: "fibrous portion of pericardium" EXACT [] synonym: "pericardium fibrosum" RELATED OMO:0003011 [Wikipedia:Fibrous_pericardium] xref: EMAPA:19029 xref: FMA:9586 xref: MA:0002738 xref: SCTID:243953008 xref: Wikipedia:Fibrous_pericardium is_a: UBERON:0000094 {source="FMA"} ! membrane organ is_a: UBERON:0005181 ! thoracic segment organ relationship: composed_primarily_of UBERON:0006815 {source="WP"} ! areolar connective tissue relationship: continuous_with UBERON:0002408 ! parietal serous pericardium relationship: part_of UBERON:0002407 {source="FMA"} ! pericardium property_value: UBPROP:0000010 "most superficial part of pericardium; continuous with the outer adventitial layer of the neighboring great blood vessels. [Wikipedia:Pericardium]" xsd:string [Term] id: UBERON:0002365 name: exocrine gland namespace: uberon def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." [Wikipedia:Exocrine_gland] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "ducted gland" EXACT [AEO:0000097] synonym: "glandula exocrina" EXACT OMO:0003011 [Wikipedia:Exocrine_gland] xref: AEO:0000097 xref: BTO:0000765 xref: CALOHA:TS-2012 xref: EHDAA2:0003097 xref: EMAPA:35327 xref: FMA:9596 xref: GAID:34 xref: MA:0002564 xref: MESH:D005088 xref: NCIT:C12712 xref: SCTID:115976003 xref: UMLS:C0015282 {source="ncithesaurus:Exocrine_Gland"} xref: Wikipedia:Exocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002330 ! exocrine system relationship: has_part UBERON:0000058 ! duct relationship: part_of UBERON:0002330 ! exocrine system property_value: editor_note "Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses" xsd:string [Term] id: UBERON:0002368 name: endocrine gland namespace: uberon def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [Wikipedia:Endocrine_gland] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "ductless gland" EXACT [AEO:0000098] synonym: "ductless gland" RELATED [Wikipedia:Ductless_gland] synonym: "glandula endocrina" EXACT [] synonym: "glandulae endocrinae" RELATED OMO:0003011 [Wikipedia:Endocrine_gland] xref: AEO:0000098 xref: BTO:0001488 xref: CALOHA:TS-1300 xref: EHDAA2:0003098 xref: EMAPA:35999 xref: FMA:9602 xref: GAID:335 xref: MA:0002563 xref: MESH:D004702 xref: NCIT:C12704 xref: SCTID:40818001 xref: UMLS:C0014133 {source="ncithesaurus:Endocrine_Gland"} xref: Wikipedia:Endocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000949 ! endocrine system relationship: capable_of GO:0046879 ! hormone secretion relationship: part_of UBERON:0000949 ! endocrine system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png xsd:anyURI [Term] id: UBERON:0002371 name: bone marrow namespace: uberon def: "The soft tissue that fills the cavities of bones." [MGI:cwg, MP:0002397] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "medulla of bone" RELATED [BTO:0000141] synonym: "medulla ossea" EXACT OMO:0003011 [BTO:0000141, FMA:9608] synonym: "medulla ossium" EXACT OMO:0003011 [BTO:0000141, Wikipedia:Bone_marrow] synonym: "medullary bone" RELATED [] xref: AAO:0011007 xref: BTO:0000141 xref: BTO:0000829 xref: CALOHA:TS-0087 xref: EFO:0000868 xref: EMAPA:32760 xref: EV:0100046 xref: FMA:9608 xref: GAID:1287 xref: galen:BoneMarrow xref: MA:0000134 xref: MAT:0000084 xref: MESH:D001853 xref: MIAA:0000084 xref: NCIT:C12431 xref: SCTID:421320006 xref: UMLS:C0005953 {source="ncithesaurus:Bone_Marrow"} xref: VHOG:0001218 xref: Wikipedia:Bone_marrow xref: XAO:0000123 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: has_part UBERON:0012429 ! hematopoietic tissue intersection_of: part_of UBERON:0001474 ! bone element relationship: has_part CL:0002092 ! bone marrow cell relationship: has_part UBERON:0012429 ! hematopoietic tissue relationship: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system relationship: part_of UBERON:0002405 ! immune system property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000009 "In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow]" xsd:string [Term] id: UBERON:0002376 name: cranial muscle namespace: uberon alt_id: UBERON:0003899 def: "Any skeletal muscle that is part of the head region." [http://orcid.org/0000-0002-6601-2165] comment: defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "adult head muscle organ" NARROW [OBOL:automatic] synonym: "cephalic muscle" EXACT [ZFA:0001652] synonym: "cephalic musculature" EXACT [] synonym: "cranial muscle" RELATED [ZFA:0001652] synonym: "head muscle" EXACT [MA:0000578] synonym: "head muscle organ" EXACT [OBOL:automatic] synonym: "head muscles" RELATED [] synonym: "muscle of head" EXACT [FMA:9616] synonym: "muscle organ of adult head" EXACT [OBOL:automatic] synonym: "muscle organ of head" EXACT [OBOL:automatic] synonym: "musculus caput" EXACT [] xref: AAO:0000107 xref: BTO:0000021 xref: EFO:0003524 xref: EHDAA2:0000322 xref: EMAPA:18172 xref: FMA:9616 xref: MA:0000578 xref: SCTID:244718003 xref: ZFA:0001652 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: attaches_to UBERON:0003129 ! skull intersection_of: part_of UBERON:0000033 ! head relationship: attaches_to UBERON:0003129 ! skull relationship: develops_from UBERON:0006904 {source="EHDAA2-abduced"} ! head mesenchyme from mesoderm relationship: has_developmental_contribution_from UBERON:0002342 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neural crest relationship: part_of UBERON:0004461 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! skeletal musculature of head property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002377 name: muscle of neck namespace: uberon def: "Any muscle that is part of the cervical (neck) region." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "muscle organ of neck" EXACT [OBOL:automatic] synonym: "muscle organ of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) muscle organ" EXACT [OBOL:automatic] synonym: "neck muscle" EXACT [] synonym: "neck muscle organ" EXACT [OBOL:automatic] xref: FMA:9617 xref: GAID:149 xref: MA:0000587 xref: MESH:D009334 xref: NCIT:C33163 xref: UMLS:C0027532 {source="ncithesaurus:Neck_Muscle"} is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0004465 {source="prolog"} ! musculature of neck property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002378 name: muscle of abdomen namespace: uberon def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." [Wikipedia:Abdominal_muscle] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "abdomen muscle" EXACT [] synonym: "abdomen muscle organ" EXACT [OBOL:automatic] synonym: "abdominal muscle" EXACT [] synonym: "abdominal wall muscle" EXACT [] synonym: "abdominal wall musculature" RELATED [EMAPA:35103] synonym: "muscle organ of abdomen" EXACT [OBOL:automatic] xref: BTO:0001261 xref: EMAPA:35103 xref: FMA:9620 xref: GAID:89 xref: MA:0000520 xref: MESH:D000009 xref: NCIT:C32040 xref: SCTID:361352008 xref: UMLS:C0000739 {source="ncithesaurus:Abdominal_Muscle"} xref: Wikipedia:Abdominal_muscle is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0002343 {source="prolog"} ! abdomen musculature relationship: part_of UBERON:0003697 ! abdominal wall property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002384 name: connective tissue namespace: uberon def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/23, PSPUB:0000170, VSAO:0000017] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Bindegewebe" RELATED [BTO:0000421] synonym: "portion of connective tissue" EXACT [FMA:9640] synonym: "textus connectivus" EXACT [] xref: AAO:0000098 xref: BTO:0000421 xref: CALOHA:TS-2009 xref: EFO:0000952 xref: EMAPA:35251 xref: FMA:9640 xref: GAID:100 xref: galen:ConnectiveTissue xref: MA:0000011 xref: MAT:0000301 xref: MESH:D003238 xref: MIAA:0000301 xref: NCIT:C12374 xref: SCTID:361919005 xref: TAO:0001641 xref: UMLS:C0009780 {source="ncithesaurus:Connective_Tissue"} xref: VSAO:0000017 xref: XAO:0001017 xref: ZFA:0001632 is_a: UBERON:0000479 ! tissue relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/wdahdul property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000098", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001641", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000001 "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000017", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} property_value: UBPROP:0000012 "MA also has set of connective tissues" xsd:string {external_ontology="MA"} [Term] id: UBERON:0002385 name: muscle tissue namespace: uberon def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." [GO:0060537, https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764, Wikipedia:Muscle_tissue] comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "muscular tissue" EXACT SENSU [] synonym: "portion of muscle tissue" EXACT [FMA:9641] synonym: "textus muscularis" EXACT [] xref: AAO:0000306 xref: AEO:0000122 xref: CALOHA:TS-0642 xref: EHDAA2:0003122 xref: EMAPA:32715 xref: FMA:9641 xref: galen:MuscleTissue xref: MA:0002437 xref: MESH:D009132 xref: NCIT:C12435 xref: SCTID:91727004 xref: UMLS:C2328219 {source="ncithesaurus:Muscle_Tissue"} xref: Wikipedia:Muscle_tissue is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of CL:0000187 ! muscle cell disjoint_from: UBERON:0003714 ! neural tissue relationship: capable_of GO:0006936 ! muscle contraction relationship: composed_primarily_of CL:0000187 ! muscle cell relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0001015 ! musculature property_value: RO:0002171 UBERON:0003714 property_value: UBPROP:0000001 "One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000306", ontology="AAO", source="AAO:LAP"} [Term] id: UBERON:0002390 name: hematopoietic system namespace: uberon def: "Anatomical system that is involved in the production of hematopoietic cells." [Wikipedia:Haematopoiesis] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Blutbildungssystem" RELATED [BTO:0000570] synonym: "haematological system" EXACT [] synonym: "haematopoietic system" RELATED [] synonym: "haemopoietic system" EXACT [] synonym: "hematological system" RELATED [] synonym: "hematolymphoid system" RELATED [] synonym: "hemopoietic system" RELATED [] synonym: "organa haemopoietica" EXACT [] xref: AAO:0011002 xref: BTO:0000570 xref: CALOHA:TS-0449 xref: EFO:0000798 xref: EMAPA:35402 xref: EV:0100045 xref: FMA:9667 xref: GAID:1008 xref: MA:0002434 xref: MAT:0000022 xref: MESH:D006413 xref: MIAA:0000022 xref: NCIT:C12909 xref: SCTID:362587009 xref: TAO:0005023 xref: UMLS:C0018957 {source="ncithesaurus:Hematopoietic_System"} xref: VHOG:0001624 xref: Wikipedia:Haematopoiesis xref: XAO:0000122 xref: ZFA:0005023 is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: develops_from UBERON:0003061 {evidence="definitional"} ! blood island relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0002193 {source="FMA"} ! hemolymphoid system property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical system that consists of the blood and blood forming tissues.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011002", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001624", ontology="VHOG", source="DOI:10.1016/j.coph.2010.05.004 Ellett F, Lieschke GJ, Zebrafish as a model for vertebrate hematopoiesis. Current Opinion in Pharmacology (2010)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "hematopoietic" xsd:string property_value: UBPROP:0000008 "In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes" xsd:string {source="WP"} [Term] id: UBERON:0002394 name: bile duct namespace: uberon def: "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Bile_duct] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "bile tube" RELATED [] synonym: "biliary duct" RELATED [FMA:9706] synonym: "gall duct" RELATED [BTO:0000122] synonym: "hepatic duct" RELATED INCONSISTENT [ZFA:0001100] xref: AAO:0011019 xref: BTO:0000122 xref: CALOHA:TS-0075 xref: EMAPA:35171 xref: EV:0100091 xref: FMA:9706 xref: GAID:280 xref: MA:0000354 xref: MESH:D001652 xref: NCIT:C12376 xref: SCTID:276157007 xref: TAO:0001100 xref: UMLS:C0005400 {source="ncithesaurus:Bile_Duct"} xref: VHOG:0000212 xref: Wikipedia:Bile_duct xref: XAO:0000134 xref: ZFA:0001100 is_a: UBERON:0000025 ! tube is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001173 ! biliary tree relationship: channel_for UBERON:0001970 ! bile relationship: contributes_to_morphology_of UBERON:0001173 ! biliary tree relationship: develops_from UBERON:0008835 {source="XAO"} ! hepatic diverticulum relationship: part_of UBERON:0001173 {source="EMAPA", source="MA"} ! biliary tree property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI property_value: UBPROP:0000001 "A duct that carries bile from the liver to the intestine." xsd:string {source="ZFA:0001100, ZFA:curator"} property_value: UBPROP:0000001 "Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000212", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/bile+duct"} property_value: UBPROP:0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000212", ontology="VHOG", source="DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "we place the ZFA class here as this fits its textual definition and child nodes. We may recommend a label change for ZFA" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0002396 name: vomer namespace: uberon def: "The triangular flat bone of the nasal septum." [ISBN:0-683-40008-8, MP:0000098] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "prevomer" RELATED [TAO:0000308] synonym: "vomer bone" EXACT [] xref: AAO:0000633 xref: FMA:9710 xref: MA:0001496 xref: MESH:D055172 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C33888 xref: SCTID:272678009 xref: TAO:0000308 xref: UMLS:C0242403 {source="ncithesaurus:Vomer"} xref: Wikipedia:Vomer xref: ZFA:0000308 is_a: UBERON:0008001 {source="FMA"} ! irregular bone is_a: UBERON:0011597 ! bone of upper jaw is_a: UBERON:0012071 ! palate bone relationship: connected_to UBERON:0001677 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! sphenoid bone relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! ethmoid bone relationship: contributes_to_morphology_of UBERON:0011156 ! facial skeleton relationship: part_of UBERON:0011085 ! palatoquadrate arch property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000308", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000633", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000308", ontology="TAO"} property_value: UBPROP:0000002 "relationship loss: overlaps mesethmoid-vomer joint (TAO:0001680)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000308", ontology="TAO"} property_value: UBPROP:0000003 "In bony fish, the vomers are flattened, paired, bones forming the anterior part of the roof of the mouth, just behind the premaxillary bones. In many species, they have teeth, supplementing those in the jaw proper; in some extinct species the teeth on the vomers were actually larger than the primary set. In amphibians and reptiles, the vomers become narrower, due to the presence of the enlarged choanae (the inner part of the nostrils) on either side, and they may extend further back in the jaw. They are typically small in birds, where they form the upper hind part of the beak, again being located between the choanae. In mammals, the vomers have become narrower still, and are fused into a single, vertically oriented bone. The development of the hard palate beneath the vomer means that the bone is now located in a nasal chamber, separate from the mouth[WP]" xsd:string {source="Wikipedia:Vomer#In_other_animals"} property_value: UBPROP:0000005 "The vomer is paired in some taxa (e.g., Amia) while unpaired in others (e.g., teleosts).[TAO]" xsd:string {date_retrieved="2012-09-06", external_class="TAO:0000308", ontology="TAO", source="Curator"} [Term] id: UBERON:0002400 name: parietal pleura namespace: uberon def: "The outer serous membrane of the pulmonary pleural." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] comment: the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "pleura parietalis" RELATED OMO:0003011 [Wikipedia:Parietal_pleura] xref: EMAPA:16776 xref: FMA:9733 xref: MA:0002488 xref: NCIT:C33273 xref: SCTID:361998003 xref: UMLS:C0225777 {source="ncithesaurus:Parietal_Pleura"} xref: VHOG:0001495 xref: Wikipedia:Parietal_pleura is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: adjacent_to UBERON:0002224 ! thoracic cavity intersection_of: part_of UBERON:0000977 ! pleura relationship: adjacent_to UBERON:0002224 ! thoracic cavity relationship: contributes_to_morphology_of UBERON:0000977 ! pleura relationship: innervated_by UBERON:0003727 ! intercostal nerve relationship: part_of UBERON:0000977 ! pleura [Term] id: UBERON:0002401 name: visceral pleura namespace: uberon def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "lung mesothelium" RELATED [EHDAA2:0002205] synonym: "lung pleura" RELATED [] synonym: "pleura pulmonalis" EXACT OMO:0003011 [FMA:9734, FMA:TA] synonym: "pleura visceralis" EXACT OMO:0003011 [Wikipedia:Visceral_pleura] synonym: "pleura visceralis (pulmonalis)" EXACT [] synonym: "pulmonary pleura" RELATED INCONSISTENT [FMA:9734] synonym: "pulmonary visceral pleura" EXACT [] xref: EHDAA2:0002205 xref: EMAPA:16777 xref: FMA:9734 xref: MA:0002489 xref: NCIT:C33881 xref: SCTID:361997008 xref: UMLS:C0225776 {source="ncithesaurus:Visceral_Pleura"} xref: VHOG:0001496 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0004923 ! organ component layer intersection_of: adjacent_to UBERON:0002048 ! lung intersection_of: part_of UBERON:0000977 ! pleura relationship: adjacent_to UBERON:0002048 ! lung relationship: attaches_to UBERON:0008946 ! lung parenchyma relationship: contributes_to_morphology_of UBERON:0000977 ! pleura relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0002048 {source="FMA"} ! lung property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]." xsd:string {source="Wikipedia:Visceral_pleura"} property_value: UBPROP:0000012 "FMA treats this as part of the lungs" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002402 name: pleural cavity namespace: uberon def: "The fluid-filled cavity that lies between the visceral and parietal pleurae." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pleural_cavity] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cavitas pleuralis" EXACT OMO:0003011 [Wikipedia:Pleural_cavity] synonym: "cavitum pleuralae" RELATED OMO:0003011 [Wikipedia:Pleural_cavity] synonym: "cavitum pleurale" RELATED OMO:0003011 [Wikipedia:Pleural_cavity] xref: BTO:0004422 xref: EHDAA2:0001475 xref: EMAPA:16773 xref: EMAPA:16774 xref: FMA:9740 xref: GAID:95 xref: MA:0000055 xref: MESH:D035422 xref: NCIT:C12840 xref: SCTID:361999006 xref: UMLS:C0178802 {source="ncithesaurus:Pleural_Cavity"} xref: VHOG:0000581 xref: Wikipedia:Pleural_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: luminal_space_of UBERON:0009778 ! pleural sac relationship: adjacent_to UBERON:0002400 ! parietal pleura relationship: adjacent_to UBERON:0002401 ! visceral pleura relationship: develops_from UBERON:0003887 {source="Wikipedia"} ! intraembryonic coelom relationship: luminal_space_of UBERON:0009778 ! pleural sac relationship: part_of UBERON:0009778 ! pleural sac property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png xsd:anyURI property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000581", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"} property_value: UBPROP:0000009 "The contraction of the diaphragm creates a negative pressure within the pleural cavity which forces the lungs to expand resulting in passive exhalation and active inhalation. This breathing process can be made forceful through the contraction of the external intercostal muscles which forces the rib cage to expand and add to the negative pressure in the pleural cavity causing the lungs to fill with air. The fluid in the cavity provides lubrication and cushioning" xsd:string property_value: UBPROP:0000012 "the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0002405 name: immune system namespace: uberon def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [Wikipedia:Immune_system] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0011003 xref: BILA:0000104 xref: BTO:0005810 xref: FMA:9825 xref: GAID:328 xref: MA:0002711 xref: MESH:D007107 xref: NCIT:C12735 xref: SCTID:362590003 xref: TAO:0001159 xref: UMLS:C0020962 {source="ncithesaurus:Immune_System"} xref: VHOG:0001247 xref: Wikipedia:Immune_system xref: XAO:0003152 xref: ZFA:0001159 is_a: UBERON:0015203 ! non-connected functional system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0002376 ! immune system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: protects UBERON:0000468 ! multicellular organism property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001247", ontology="VHOG", source="PMID:21046016 Dzik JM, The ancestry and cumulative evolution of immune reactions. Acta biochimica Polonica (2010)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002406 name: pericardial sac namespace: uberon def: "A double-walled sac containing the heart and the roots of the great vessels." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pericardium] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "pericardium" RELATED [] xref: FMA:9868 xref: RETIRED_EHDAA2:0001443 xref: SCTID:361326002 is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0005906 ! serous sac intersection_of: UBERON:0005906 ! serous sac intersection_of: has_part UBERON:0001074 ! pericardial cavity intersection_of: has_part UBERON:0002357 ! serous pericardium relationship: has_part UBERON:0001074 ! pericardial cavity relationship: has_part UBERON:0002357 ! serous pericardium relationship: part_of UBERON:0002407 ! pericardium relationship: surrounded_by UBERON:0002359 {source="FMA"} ! fibrous pericardium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png xsd:anyURI [Term] id: UBERON:0002407 name: pericardium namespace: uberon def: "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pericardium] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0010817 xref: BSA:0000090 xref: BTO:0000717 xref: CALOHA:TS-0761 xref: EFO:0000820 xref: EHDAA:5376 xref: EV:0100023 xref: FMA:9869 xref: GAID:569 xref: galen:Pericardium xref: MA:0000099 xref: MAT:0000454 xref: MESH:D010496 xref: NCIT:C13005 xref: RETIRED_EHDAA2:0001443 xref: SCTID:181295003 xref: UMLS:C0031050 {source="ncithesaurus:Pericardium"} xref: VHOG:0001280 xref: Wikipedia:Pericardium xref: XAO:0004182 xref: ZFA:0000054 is_a: UBERON:0000481 ! multi-tissue structure relationship: has_part UBERON:0002359 ! fibrous pericardium relationship: has_part UBERON:0002406 ! pericardial sac relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0015410 {source="MA"} ! heart plus pericardium relationship: surrounds UBERON:0002349 ! myocardium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Peritoneum that surrounds the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010817", ontology="AAO", source="AAO:JMG"} property_value: UBPROP:0000007 "pericardial" xsd:string property_value: UBPROP:0000012 "In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity" xsd:string {external_ontology="FMA"} property_value: UBPROP:0000012 "this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO)" xsd:string {external_ontology="ZFA"} property_value: UBPROP:0000012 "we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002408 name: parietal serous pericardium namespace: uberon def: "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "lamina parietalis (pericardii serosum)" EXACT [] synonym: "lamina parietalis pericardii" EXACT OMO:0003011 [FMA:9870, FMA:TA] synonym: "parietal layer of serous pericardium" EXACT [] synonym: "parietal pericardium" EXACT [VHOG:0000537] synonym: "pericardial sac" RELATED INCONSISTENT [DOI:10.5962/bhl.title.1013] xref: EHDAA:3422 xref: EHDAA:5378 xref: EMAPA:19031 xref: FMA:9870 xref: MA:0000483 xref: NCIT:C94500 xref: SCTID:243956000 xref: UMLS:C0225969 {source="ncithesaurus:Parietal_Pericardium"} xref: VHOG:0000537 xref: Wikipedia:Parietal_pericardium is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: part_of UBERON:0002357 ! serous pericardium relationship: attaches_to UBERON:0006670 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! central tendon of diaphragm relationship: part_of UBERON:0002357 ! serous pericardium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png xsd:anyURI [Term] id: UBERON:0002409 name: pericardial fluid namespace: uberon def: "Transudate contained in the pericardial cavity.[FMA]." [FMA:9887, Wikipedia:Pericardial_fluid] subset: human_subset subset: mouse_subset subset: uberon_slim xref: BTO:0001016 xref: FMA:9887 xref: MA:0002530 xref: MESH:D000069236 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: Wikipedia:Pericardial_fluid is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0002425 ! visceral serous pericardium relationship: located_in UBERON:0001074 ! pericardial cavity relationship: produced_by UBERON:0002425 ! visceral serous pericardium [Term] id: UBERON:0002410 name: autonomic nervous system namespace: uberon def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [GO:0048483] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ANS" RELATED OMO:0003000 [] synonym: "autonomic division of peripheral nervous system" EXACT [FMA:65553] synonym: "autonomic part of peripheral nervous system" EXACT [FMA:65553] synonym: "divisio autonomica systematis nervosi peripherici" EXACT [FMA:TA] synonym: "divisio autonomica systematis nervosi peripherici" RELATED OMO:0003011 [Wikipedia:Autonomic_nervous_system] synonym: "pars autonomica systematis nervosi peripherici" EXACT [FMA:TA] synonym: "peripheral autonomic nervous system" EXACT [FMA:65553] synonym: "visceral nervous system" EXACT [] xref: AAO:0000033 xref: BIRNLEX:1123 xref: BTO:0002507 xref: CALOHA:TS-2001 xref: EHDA:10095 xref: EHDAA2:0000158 xref: EHDAA:3767 xref: EMAPA:16984 xref: FMA:65553 xref: GAID:706 xref: IDOMAL:0002126 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MA:0000219 xref: MESH:D001341 xref: NCIT:C12673 xref: neuronames:2054 xref: SCTID:362481007 xref: TAO:0001574 xref: UMLS:C0004388 {source="ncithesaurus:Autonomic_Nervous_System", source="BIRNLEX:1123"} xref: UMLS:C1305381 {source="BIRNLEX:1123"} xref: VHOG:0000396 xref: Wikipedia:Autonomic_nervous_system xref: ZFA:0001574 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000010 {source="EMAPA", source="MA", source="NIFSTD", source="ZFA-modified-from-isa"} ! peripheral nervous system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png xsd:anyURI property_value: UBPROP:0000001 "Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000396", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000033", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000396", ontology="VHOG", source="DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002412 name: vertebra namespace: uberon def: "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vertebra bone" EXACT [] synonym: "vertebrae" EXACT OMO:0003004 [PHENOSCAPE:ad] xref: AAO:0000691 xref: BTO:0006196 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: CALOHA:TS-2352 xref: EFO:0001371 xref: EMAPA:32740 xref: FMA:9914 xref: galen:Vertebra xref: MA:0000309 xref: NCIT:C12933 xref: SCTID:181817002 xref: TAO:0001189 xref: UMLS:C0549207 {source="ncithesaurus:Vertebra"} xref: Wikipedia:Vertebra xref: XAO:0004019 xref: ZFA:0001189 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0008001 {source="FMA"} ! irregular bone is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0011094 ! vertebra cartilage element relationship: part_of UBERON:0001130 ! vertebral column property_value: editor_note "Consider changing name to make distinction from inferred superclass 'vertebral element' clear" xsd:string property_value: editor_note "we follow FMA in making this an irregular bone - however vertebra have 'epiphyses' which are currently classified as belonging to long bones" xsd:string property_value: RO:0002161 NCBITaxon:7901 {source="Wikipedia"} property_value: UBPROP:0000001 "Endochondral bone that forms around the notochord and is part of the vertebral column.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001189", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Main component of the vertebral column. It consists of two essential parts, a dorsal neural arch and a ventral centrum.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000691", ontology="AAO", source="AAO:Pugener_and_Maglia_2008"} [Term] id: UBERON:0002413 name: cervical vertebra namespace: uberon def: "A vertebra that is located in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cervical vertebrae" EXACT OMO:0003004 [] synonym: "vertebrae cervicales" RELATED OMO:0003011 [Wikipedia:Cervical_vertebrae] xref: EMAPA:17674 xref: FMA:9915 xref: GAID:235 xref: galen:CervicalVertebra xref: MA:0000311 xref: MESH:D002574 xref: NCIT:C12693 xref: SCTID:181820005 xref: Wikipedia:Cervical_vertebrae xref: XAO:0003076 is_a: UBERON:0003458 ! neck bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0004451 {is_inferred="true"} ! trunk or cervical vertebra is_a: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0013505 ! cervical vertebra cartilage element property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "In some species, some parts of the skull may be composed of vertebra-like elements, e.g. the occipital bone in humans is composed of four vertebra-like segments. In many vertebrate species, cervical vertebrae are variable in number; however, almost all mammals have seven (including those with very short necks relative to body size, such as elephants or whales, and those with very long necks, such as giraffes). The few exceptions include the manatee and the sloths, of which the two-toed sloth has six cervical vertebrae and the three-toed sloth has up to nine cervical vertebrae. In many species, though not in mammals, the cervical vertebrae bear ribs. In many other groups, such as lizards and saurischian dinosaurs, the cervical ribs are large; in birds they are small and completely fused to the vertebrae. The transverse processes of mammals are homologous to the cervical ribs of other amniotes. Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, cervical vertebrae are the smallest of the true vertebrae, and can be readily distinguished from those of the thoracic or lumbar regions by the presence of a foramen (hole) in each transverse process, through which passes the vertebral artery." xsd:string [Term] id: UBERON:0002415 name: tail namespace: uberon def: "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." [AEO:0000109, Wikipedia:Tail] subset: efo_slim subset: grouping_class subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "caudal subdivision" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AEO:0000109 xref: BILA:0000117 xref: BTO:0001348 xref: EFO:0000963 xref: EHDAA:9198 xref: GAID:1245 xref: MAT:0000094 xref: MESH:D013623 xref: MIAA:0000094 xref: WBbt:0005741 xref: Wikipedia:Tail is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of UBERON:0000154 ! posterior region of body property_value: editor_note "Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin" xsd:string property_value: RO:0002161 NCBITaxon:9606 [Term] id: UBERON:0002416 name: integumental system namespace: uberon alt_id: UBERON:0007029 def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." [CARO:0002001, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/29] subset: efo_slim subset: grouping_class subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "body surface" RELATED [] synonym: "dermal system" RELATED [MIAA:0000033] synonym: "external covering of organism" RELATED [] synonym: "integumentary system" EXACT [FMA:72979] synonym: "integumentum commune" RELATED OMO:0003011 [Wikipedia:Integumentary_system] synonym: "organism surface" RELATED [EHDAA2:0003154] synonym: "surface" RELATED [BILA:0000118] xref: AEO:0000154 xref: BILA:0000118 xref: CALOHA:TS-1299 xref: CARO:0002001 xref: EFO:0000807 xref: EHDAA2:0000836 xref: EHDAA2_RETIRED:0003154 xref: EHDAA:6520 xref: EMAPA:17524 xref: EV:0100151 xref: FBbt:00004969 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:72979 xref: galen:Surface xref: HAO:0000421 xref: MA:0000014 xref: MAT:0000033 xref: MESH:D034582 xref: MIAA:0000033 xref: NCIT:C12907 xref: SCTID:361692004 xref: TADS:0000108 xref: UMLS:C0037267 {source="ncithesaurus:Integumentary_System"} xref: VHOG:0000403 xref: Wikipedia:Integumentary_system xref: XAO:0000176 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: bounding_layer_of UBERON:0000468 ! multicellular organism relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0007376 ! outer epithelium relationship: surrounded_by UBERON:0013514 ! space surrounding organism property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tfhayamizu property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "(...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000403", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002417 name: abdominal segment of trunk namespace: uberon def: "The abdominal segment of the torso." [Wikipedia:Lumbar] subset: human_subset subset: mouse_subset synonym: "abdomen/pelvis/perineum" RELATED [MA:0000021] synonym: "lower body" RELATED [MA:0000021] synonym: "lower trunk" RELATED [FMA:259211] synonym: "lumbar region" RELATED [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:35104 xref: FMA:259211 xref: MA:0000021 xref: SCTID:362875007 xref: Wikipedia:Lumbar is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis [Term] id: UBERON:0002418 name: cartilage tissue namespace: uberon def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/37, https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5, PSPUB:0000170, VSAO:0000040] comment: Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cartilage" RELATED [] synonym: "cartilage tissue" EXACT [FMA:37377] synonym: "cartilages" RELATED [VHOG:0001207] synonym: "cartilaginous tissue" EXACT [] synonym: "chondrogenic tissue" EXACT [VSAO:0000040] synonym: "portion of cartilage tissue" RELATED [FMA:37377] xref: AAO:0000060 xref: AEO:0000087 xref: BTO:0000206 xref: EFO:0000949 xref: EHDAA2:0003087 xref: EMAPA:32730 xref: EV:0100141 xref: FMA:37377 xref: GAID:99 xref: galen:Cartilage xref: MA:0000104 xref: MAT:0000189 xref: MESH:D002356 xref: MIAA:0000189 xref: NCIT:C12373 xref: NCIT:C32268 xref: SCTID:309312004 xref: TAO:0001501 xref: UMLS:C0007301 {source="ncithesaurus:Cartilage"} xref: VHOG:0001207 xref: VSAO:0000040 xref: Wikipedia:Cartilage xref: XAO:0000170 xref: ZFA:0005622 is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0002481 {source="https://github.com/obophenotype/uberon/issues/117"} ! bone tissue relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system relationship: has_part CHEBI:18085 ! glycosaminoglycan relationship: has_part CL:0000138 ! chondrocyte relationship: in_taxon NCBITaxon:33213 ! Bilateria property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mellybelly property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg xsd:anyURI property_value: UBPROP:0000001 "A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000060", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001501", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000040", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} property_value: UBPROP:0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000060", ontology="AAO"} property_value: UBPROP:0000003 "Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001207", ontology="VHOG", source="DOI:10.1111/j.1525-142X.2011.00520.x Hall BK, Parallelism, deep homology, and evo-devo. Evolution and Development (2012)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002419 name: skin gland namespace: uberon def: "A gland that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: organ_slim synonym: "glandulae cutis" EXACT OMO:0003011 [FMA:71878, FMA:TA] synonym: "set of skin glands" RELATED [FMA:71878] synonym: "skin glands" RELATED OMO:0003004 [] synonym: "skin glands set" RELATED OMO:0003004 [] xref: EMAPA:35774 xref: FMA:71878 xref: MA:0000146 xref: SCTID:110485007 is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0006003 ! integumentary adnexa intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body property_value: editor_note "check FMA, use plural for now as general class not there" xsd:string [Term] id: UBERON:0002423 name: hepatobiliary system namespace: uberon def: "The part of the digestive system that contains the liver and the biliary system." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepaticobiliary system" EXACT [GO:0061008] synonym: "liver and biliary system" EXACT [] synonym: "liver/biliary system" RELATED [] xref: AAO:0011056 xref: CALOHA:TS-1308 xref: EFO:0000800 xref: EHDAA2:0000998 xref: EHDAA:2189 xref: EMAPA:16840 xref: EV:0100088 xref: MA:0000324 xref: MAT:0000024 xref: MIAA:0000024 xref: NCIT:C43612 xref: TAO:0000036 xref: UMLS:C1711359 {source="ncithesaurus:Hepatobiliary_System"} xref: VHOG:0000294 xref: Wikipedia:Hepatobiliary_system xref: XAO:0000132 xref: ZFA:0000036 is_a: UBERON:0011216 ! organ system subdivision disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0061007 ! hepaticobiliary system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0002107 ! liver relationship: has_part UBERON:0002294 ! biliary system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001007 ! digestive system property_value: UBPROP:0000001 "System responsible for the production and movement of bile[ZFIN:curator]." xsd:string {source="ZFIN:curator"} property_value: UBPROP:0000009 "The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. The parts are: liver, bile duct, gall bladder and hepatic duct [GO:0061008]" xsd:string [Term] id: UBERON:0002424 name: oral epithelium namespace: uberon def: "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "epithelium of mucosa of mouth" EXACT [FMA:265152] synonym: "epithelium of oral mucosa" EXACT [FMA:265152] xref: AAO:0010357 xref: BTO:0001775 xref: CALOHA:TS-0715 xref: EHDAA2:0001325 xref: EHDAA:2187 xref: EMAPA:16839 xref: EMAPA:26942 xref: FMA:265152 xref: MA:0000344 xref: NCIT:C49595 xref: TAO:0000816 xref: UMLS:C1709332 {source="ncithesaurus:Oral_Cavity_Epithelium"} xref: VHOG:0000187 xref: XAO:0003201 xref: ZFA:0000816 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0006915 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! stratified squamous epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0003729 ! mouth mucosa relationship: adjacent_to UBERON:0000167 {source="AAO-modified"} ! oral cavity relationship: part_of UBERON:0003729 ! mouth mucosa property_value: editor_note "consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar)" xsd:string property_value: UBPROP:0000001 "The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]." xsd:string {source="ZFA:0000816"} property_value: UBPROP:0000011 "the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme" xsd:string {source="PMID:16488870"} [Term] id: UBERON:0002425 name: visceral serous pericardium namespace: uberon def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." [Wikipedia:Visceral_pericardium] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "epicardium" RELATED [MA:0000484] synonym: "lamina visceralis pericardii serosi" EXACT OMO:0003011 [Wikipedia:Epicardium] synonym: "pericardium visceral mesothelium" RELATED [EMAPA:16589] synonym: "serous visceral pericardium" EXACT [] synonym: "visceral lamina of serous pericardium" EXACT [] synonym: "visceral layer of serous pericardium" EXACT [] synonym: "visceral pericardium" EXACT [VHOG:0000538] xref: EMAPA:19032 xref: FMA:84882 xref: MA:0000484 xref: SCTID:243955001 xref: VHOG:0000538 xref: Wikipedia:Visceral_pericardium is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: part_of UBERON:0002357 ! serous pericardium relationship: attaches_to UBERON:0002349 {source="FMA"} ! myocardium relationship: contributes_to_morphology_of UBERON:0002407 ! pericardium relationship: has_part UBERON:0002348 {source="cjm"} ! epicardium relationship: part_of UBERON:0002357 ! serous pericardium [Term] id: UBERON:0002443 name: choroidal blood vessel namespace: uberon def: "A blood vessel that is part of a choroid [Automatically generated definition]." [OBOL:automatic] comment: cannot find singular in FMA, using Set class subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel of choroid" EXACT [OBOL:automatic] synonym: "blood vessel of choroid coat" EXACT [OBOL:automatic] synonym: "blood vessel of choroidea" EXACT [OBOL:automatic] synonym: "blood vessel of posterior uvea" EXACT [OBOL:automatic] synonym: "choroid blood vessel" EXACT [OBOL:automatic] synonym: "choroid blood vessels" EXACT [] synonym: "choroid blood vessels set" EXACT [] synonym: "choroid coat blood vessel" EXACT [OBOL:automatic] synonym: "choroidea blood vessel" EXACT [OBOL:automatic] synonym: "posterior uvea blood vessel" EXACT [OBOL:automatic] synonym: "set of choroid blood vessels" RELATED [FMA:76550] synonym: "vasa sanguinea choroideae" EXACT OMO:0003011 [FMA:76550, FMA:TA] xref: EMAPA:17828 xref: FMA:76550 xref: MA:0001237 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid [Term] id: UBERON:0002457 name: intersomitic artery namespace: uberon alt_id: UBERON:0006001 def: "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." [MP:0010662] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "intersegmental arteries" RELATED OMO:0003004 [ZFA:0001061] synonym: "intersegmental artery" EXACT [ZFA:0001061] xref: EHDAA2:0000882 xref: EHDAA:4340 xref: EMAPA:17616 xref: MA:0001985 xref: SCTID:360401001 xref: TAO:0001061 xref: VHOG:0000225 xref: XAO:0004165 xref: ZFA:0001061 is_a: UBERON:0001637 ! artery is_a: UBERON:0014907 ! intersomitic vessel property_value: UBPROP:0000001 "Arteries that connect the dorsal aorta and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these vessels don't have venous or arteriproperty_value external_definitionmarkers. They form from the primary sprouts from the dorsal aorta[ZFA:0001061]." xsd:string {source="ZFA:0001061"} property_value: UBPROP:0000003 "Few changes of evolutionary significance occur in the branching pattern of the dorsal aorta. All vertebrates have (...) paired intersegmental arteries to the trunk, tail, and paired appendages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000225", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.612", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002458 name: spinal artery namespace: uberon def: "Arteries that supply the spinal cord." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Spinal_artery] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "spinal arteries" EXACT OMO:0003004 [ZFA:0000682] xref: EHDAA2:0001890 xref: EHDAA:4355 xref: EMAPA:18241 xref: MA:0002043 xref: NCIT:C33587 xref: SCTID:244228006 xref: TAO:0000682 xref: UMLS:C0447043 {source="ncithesaurus:Spinal_Artery"} xref: Wikipedia:Spinal_artery xref: ZFA:0000682 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0002240 ! spinal cord relationship: part_of RO:0002577 ! system relationship: vessel_supplies_blood_to UBERON:0002240 ! spinal cord [Term] id: UBERON:0002466 name: intestine secretion namespace: uberon def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [Wikipedia:Succus_entericus] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "intestinal juice" RELATED [BTO:0000644] synonym: "intestinal secretion" EXACT [FMA:62974] synonym: "succus entericus" EXACT [Wikipedia:Succus_entericus] xref: BTO:0000644 xref: FMA:62974 xref: GAID:1162 xref: MA:0002515 xref: MESH:D007419 xref: NCIT:C32875 xref: UMLS:C0021849 {source="ncithesaurus:Intestinal_Secretion"} xref: Wikipedia:Succus_entericus is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: produced_by UBERON:0000160 ! intestine relationship: produced_by UBERON:0000160 ! intestine [Term] id: UBERON:0002469 name: esophagus mucosa namespace: uberon alt_id: UBERON:0003345 def: "A mucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "esophageal mucosa" EXACT [] synonym: "esophageal mucous membrane" EXACT [] synonym: "esophagus mucosa" EXACT [FMA:62996] synonym: "esophagus mucous membrane" EXACT [OBOL:automatic] synonym: "lamina muscularis mucosae oesophageae" EXACT OMO:0003011 [FMA:62996, FMA:TA] synonym: "mucosa of esophagus" EXACT [OBOL:automatic] synonym: "mucosa of oesophagus" EXACT [OBOL:automatic] synonym: "mucous membrane of esophagus" EXACT [] synonym: "mucous membrane of oesophagus" EXACT [FMA:62996] synonym: "muscularis mucosae of oesophagus" RELATED INCONSISTENT [FMA:62996] synonym: "oesophageal mucosa" EXACT [FMA:62996] synonym: "oesophagus mucosa" EXACT [] synonym: "oesophagus mucous membrane" EXACT [OBOL:automatic] synonym: "tunica mucosa esophagi" EXACT [] synonym: "tunica mucosa oesophageae" EXACT OMO:0003011 [FMA:62996, FMA:TA] synonym: "tunica mucosa oesophagi" EXACT [] synonym: "tunica mucosa oesophagi" RELATED [BTO:0002859] xref: BTO:0002859 xref: EMAPA:26981 xref: FMA:62996 xref: MA:0002680 xref: MESH:D000071041 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C32538 xref: SCTID:362127004 xref: UMLS:C0227176 {source="ncithesaurus:Esophageal_Mucosa"} is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 ! wall of esophagus [Term] id: UBERON:0002481 name: bone tissue namespace: uberon def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000047] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "bone" RELATED [MESH:A02.835.232] synonym: "calcium tissue" EXACT [] synonym: "mineralized bone tissue" NARROW [XAO:0004040] synonym: "osseous tissue" EXACT [] synonym: "osteogenic tissue" EXACT [VSAO:curator] synonym: "portion of bone tissue" RELATED [FMA:224804] xref: CALOHA:TS-2011 xref: EMAPA:35179 xref: FMA:224804 xref: galen:BoneTissue xref: MA:0002780 xref: MESH:D001842 xref: NCIT:C13076 xref: UMLS:C0391978 {source="ncithesaurus:Bone_Tissue"} xref: VSAO:0000047 xref: Wikipedia:Bone_tissue xref: XAO:0004040 xref: ZFA:0005621 is_a: UBERON:0004755 {source="VSAO"} ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001474 ! bone element property_value: editor_note "see https://github.com/obophenotype/uberon/issues/27" xsd:string property_value: UBPROP:0000001 "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000047", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} [Term] id: UBERON:0002506 name: iris epithelium namespace: uberon def: "An epithelium that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "epithelial tissue of iris" EXACT [OBOL:automatic] synonym: "epithelium of iris" EXACT [OBOL:automatic] synonym: "epithelium pigmentosum (iris)" EXACT [FMA:58517] synonym: "epithelium pigmentosum iridis" EXACT OMO:0003011 [FMA:58517, FMA:TA] synonym: "iris epithelial tissue" EXACT [OBOL:automatic] synonym: "iris epithelium" EXACT [FMA:58517] synonym: "iris pigmented epithelium" RELATED [MA:0002826] synonym: "pigmented epithelium of iris" EXACT [FMA:58517] xref: EMAPA:35447 xref: FMA:58517 xref: MA:0002826 is_a: UBERON:0000488 {source="FMA"} ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001769 ! iris relationship: contributes_to_morphology_of UBERON:0001769 ! iris relationship: has_part GO:0048770 {source="MP"} ! pigment granule relationship: part_of UBERON:0001769 {source="MA"} ! iris property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002511 name: trabecula carnea namespace: uberon def: "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart." [MGI:monikat, MP:0004067] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cardiac trabecula" RELATED [GO:0060347] synonym: "columnae carneae" RELATED OMO:0003011 [Wikipedia:Trabeculae_carneae] synonym: "heart trabecula" RELATED [GO:0060347] synonym: "trabecula of heart" RELATED [] synonym: "trabeculae carneae" RELATED OMO:0003004 [] synonym: "trabeculae carneae cordis" RELATED OMO:0003011 [Wikipedia:Trabeculae_carneae] synonym: "ventricle trabecula carnea" EXACT [MA:0002831] synonym: "ventricular trabecula" RELATED [MA:0002831] xref: EMAPA:18626 xref: FMA:7269 xref: MA:0002831 xref: SCTID:118755002 xref: Wikipedia:Trabeculae_carneae is_a: UBERON:0000440 ! trabecula relationship: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue relationship: part_of UBERON:0002082 {source="WP"} ! cardiac ventricle property_value: UBPROP:0000009 "The purpose of the trabeculae carneae is most likely to prevent suction that would occur with a flat surfaced membrane and thus impair the heart's ability to pump efficiently. The trabeculae carneae also serve a similar function to papillary muscles in that their contraction pulls on the chordae tendineae, preventing inversion of the mitral (bicuspid) and tricuspid valves, that is, their bulging towards the atrial chambers, which would lead to subsequent leakage of the blood into the atria. So by the action of papillary muscles on the atrioventricular valves, backflow of the blood from the ventricles into the atria is prevented" xsd:string {source="WP"} property_value: UBPROP:0000012 "Note that WP states they are ventricular, but MP has classes for atrial ventricular carnea." xsd:string {external_ontology="MP"} [Term] id: UBERON:0002513 name: endochondral bone namespace: uberon def: "Replacement bone that forms within cartilage." [GO:0001958, GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/54, VSAO:0000145] subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "cartilaginous bone" RELATED [BTO:0002157] synonym: "endochondral bones" RELATED OMO:0003004 [ZFA:0001591] synonym: "ossified chondrogenic bone" EXACT [VSAO:0000145] xref: AAO:0010776 xref: AEO:0000083 xref: BTO:0002157 xref: EHDAA2:0003083 xref: FMA:24321 xref: TAO:0001591 xref: VSAO:0000145 xref: XAO:0004018 xref: ZFA:0001591 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 {source="VSAO"} ! endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: develops_from UBERON:0005863 ! cartilaginous condensation relationship: developmentally_replaces UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0007844 {source="VSAO"} ! cartilage element property_value: editor_note "placement in this class to be inferred" xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mellybelly property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/wdahdul property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern xsd:anyURI property_value: UBPROP:0000001 "Replacement bone that forms within cartilage.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000145", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} property_value: UBPROP:0000012 "some structures, e.g. in ZFA are both intramembrane and endochondral" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0002514 name: intramembranous bone namespace: uberon def: "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, https://github.com/obophenotype/uberon/issues/267, Wikipedia:Intramembranous_ossification] subset: human_subset subset: mouse_subset synonym: "intramembranous bones" RELATED OMO:0003004 [ZFA:0001635] synonym: "membrane bone" RELATED [AEO:0000085] xref: EMAPA:36615 xref: TAO:0001644 xref: Wikipedia:Intramembranous_ossification xref: ZFA:0001635 is_a: UBERON:0001474 {source="VSAO"} ! bone element relationship: develops_from UBERON:0003104 ! mesenchyme relationship: output_of GO:0001957 ! intramembranous ossification property_value: UBPROP:0000001 "Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001644", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000005 "[In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO]" xsd:string {date_retrieved="2012-09-06", external_class="TAO:0001644", ontology="TAO", source="Curator"} [Term] id: UBERON:0002517 name: basicranium namespace: uberon def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." [Wikipedia:Base_of_skull] comment: The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "base of cranium" EXACT [] synonym: "base of skull" EXACT [FMA:52801] synonym: "basis cranii" EXACT OMO:0003011 [FMA:52801, FMA:TA, Wikipedia:Base_of_skull] synonym: "cranial base" EXACT [FMA:52801, MA:0002840] xref: FMA:52801 xref: MA:0002840 xref: MESH:D019291 xref: MFMO:0000044 xref: NCIT:C12493 xref: SCTID:181890004 xref: UMLS:C0149543 {source="ncithesaurus:Base_of_the_Skull"} xref: Wikipedia:Base_of_skull is_a: UBERON:0000075 ! subdivision of skeletal system relationship: contributes_to_morphology_of UBERON:0003128 ! cranium relationship: part_of UBERON:0001703 ! neurocranium relationship: part_of UBERON:0002241 ! chondrocranium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png xsd:anyURI property_value: UBPROP:0000007 "basicranial" xsd:string [Term] id: UBERON:0002521 name: elastic tissue namespace: uberon def: "Connective tissue composed of elastic fibers." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "elastic connective tissue" EXACT [] synonym: "elastic fiber" NARROW [] synonym: "textus connectivus elasticus" EXACT OMO:0003011 [] xref: FMA:20113 xref: GAID:926 xref: MA:0002853 xref: MESH:D004547 xref: NCIT:C32495 xref: SCTID:27197004 xref: Wikipedia:Elastic_fiber is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: composed_primarily_of GO:0071953 ! elastic fiber relationship: composed_primarily_of GO:0071953 ! elastic fiber relationship: has_quality PATO:0001171 ! elastic property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png xsd:anyURI [Term] id: UBERON:0002522 name: tunica media namespace: uberon def: "The middle layer of an artery or vein. [WP,unvetted]." [Wikipedia:Tunica_media] comment: May be composed of smooth muscle and elastic tissue subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "tunica media vasorum" RELATED OMO:0003011 [BTO:0002011, Wikipedia:Tunica_media] xref: BTO:0002011 xref: EMAPA:36298 xref: FMA:55590 xref: GAID:170 xref: MA:0002855 xref: MESH:D017540 xref: NCIT:C33821 xref: SCTID:61695000 xref: UMLS:C0162867 {source="ncithesaurus:Tunica_Media"} xref: Wikipedia:Tunica_media is_a: UBERON:0004797 {source="MA"} ! blood vessel layer relationship: has_part UBERON:0002521 {source="cjm"} ! elastic tissue relationship: has_part UBERON:0004237 {source="cjm"} ! blood vessel smooth muscle relationship: surrounded_by UBERON:0005734 ! tunica adventitia of blood vessel property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg xsd:anyURI [Term] id: UBERON:0002523 name: tunica intima namespace: uberon def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." [ISBN:0073040584, NCIT:C33820, Wikipedia:Tunica_intima] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "Bichat's tunic" RELATED [BTO:0002012] synonym: "intima" RELATED [BTO:0002012] synonym: "tunica intima vasorum" RELATED [BTO:0002012] xref: BTO:0002012 xref: EMAPA:36297 xref: FMA:55589 xref: GAID:523 xref: MA:0002861 xref: MESH:D017539 xref: NCIT:C33820 xref: SCTID:8361002 xref: SCTID:87483006 xref: UMLS:C0162864 {source="ncithesaurus:Tunica_Intima"} xref: Wikipedia:Tunica_intima is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: adjacent_to UBERON:0010161 {source="ISBN:0073040584"} ! lumen of blood vessel relationship: has_part UBERON:0001986 ! endothelium relationship: surrounded_by UBERON:0002522 {notes="check for exceptions, e.g. capillaries"} ! tunica media property_value: editor_note "the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure" xsd:string property_value: editor_note "the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg xsd:anyURI property_value: UBPROP:0000001 "The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia]" xsd:string {ontology="Wikipedia", source="Wikipedia:Tunica_intima"} [Term] id: UBERON:0002530 name: gland namespace: uberon def: "An organ that functions as a secretory or excretory organ." [MGI:csmith, MP:0002163] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "Druese" RELATED [BTO:0000522] synonym: "glandula" RELATED OMO:0003011 [BTO:0000522, Wikipedia:Gland] synonym: "glandular organ" EXACT [http://orcid.org/0000-0002-6601-2165] xref: AAO:0000212 xref: AEO:0000096 xref: BTO:0000522 xref: EFO:0000797 xref: EHDAA2:0003096 xref: EHDAA:2161 xref: EMAPA:18425 xref: FBbt:00100317 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7146 xref: FMA:86294 xref: galen:Gland xref: HAO:0000375 xref: MA:0003038 xref: MAT:0000021 xref: MIAA:0000021 xref: NCIT:C13319 xref: SCTID:134358001 xref: UMLS:C1285092 {source="ncithesaurus:Gland"} xref: Wikipedia:Gland xref: WikipediaCategory:Glands is_a: UBERON:0000062 ! organ relationship: capable_of GO:0046903 ! secretion relationship: in_taxon NCBITaxon:6072 ! Eumetazoa relationship: produces UBERON:0000463 ! organism substance property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png xsd:anyURI property_value: RO:0002171 UBERON:0001434 property_value: UBPROP:0000007 "glandular" xsd:string [Term] id: UBERON:0002532 name: epiblast (generic) namespace: uberon def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." [Wikipedia:Epiblast, ZFIN:curator] subset: early_development subset: grouping_class subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "blastocyst" RELATED [] synonym: "ectoblast" RELATED [MP:0003886] synonym: "epiblast" EXACT [VHOG:0000243] synonym: "epiblastus" RELATED OMO:0003011 [Wikipedia:Epiblast] synonym: "primitive ectoderm" RELATED [VHOG:0000243] xref: BTO:0004593 xref: FMA:296704 xref: MAT:0000067 xref: MIAA:0000067 xref: VHOG:0000243 xref: Wikipedia:Epiblast is_a: UBERON:0002050 ! embryonic structure relationship: has_part CL:0000352 ! epiblast cell property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png xsd:anyURI property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002533 name: post-anal tail bud namespace: uberon def: "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." [BTO:0001445] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "end bud" RELATED [BTO:0001445] synonym: "tail bud" EXACT [ZFA:0000077] synonym: "tail bud mesenchyme" RELATED [ZFA:0000077] synonym: "tailbud" EXACT [] xref: AAO:0011104 xref: BTO:0001445 xref: EFO:0002748 xref: EHDAA2:0001976 xref: EHDAA:1595 xref: EMAPA:16580 xref: MAT:0000070 xref: MIAA:0000070 xref: TAO:0000077 xref: VHOG:0000201 xref: XAO:0000107 xref: ZFA:0000077 is_a: UBERON:0002050 ! embryonic structure relationship: in_taxon NCBITaxon:7742 ! Vertebrata property_value: editor_note "See notes from https://github.com/obophenotype/uberon/wiki/The-neural-crest" xsd:string property_value: UBPROP:0000001 "Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011104", ontology="AAO", source="ISBN:0815318960", source="OMD:tail+bud"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (5) a larva or embryo with a postanal tail.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000201", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0002536 name: arthropod sensillum namespace: uberon def: "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]." [FBbt:00007152, Wikipedia:Sensillum] subset: efo_slim subset: uberon_slim synonym: "sensillum" EXACT [FBbt:00007152, HAO:0000933] xref: BTO:0001237 xref: EFO:0000939 xref: FBbt:00007152 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000933 xref: MAT:0000163 xref: MIAA:0000163 xref: TGMA:0000540 xref: Wikipedia:Sensillum is_a: UBERON:0000020 ! sense organ relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of UBERON:0001016 ! nervous system property_value: editor_note "this term should be ceded to the arthropod anatomy ontology" xsd:string [Term] id: UBERON:0002539 name: pharyngeal arch namespace: uberon def: "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." [http://orcid.org/0000-0002-6601-2165, PMID:16313389, ZFA:yb] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arcus pharyngei" RELATED OMO:0003011 [Wikipedia:Pharyngeal_arch] synonym: "branchial arch" NARROW [BTO:0001785, MP:0002884] synonym: "pharyngeal arches" EXACT OMO:0003004 [] synonym: "visceral arch" RELATED [] xref: AAO:0010359 xref: BTO:0001785 xref: EFO:0000959 xref: EHDAA:571 xref: EMAPA:16117 xref: FMA:293015 xref: GAID:1292 xref: MAT:0000242 xref: MESH:D001934 xref: MIAA:0000242 xref: NCIT:C34249 xref: SCTID:308766004 xref: TAO:0001306 xref: UMLS:C0080322 {source="ncithesaurus:Pharyngeal_Arch"} xref: VHOG:0000155 xref: Wikipedia:Pharyngeal_arch xref: XAO:0000096 xref: ZFA:0001306 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: developmentally_induced_by UBERON:0007690 {source="PMID:16313389"} ! early pharyngeal endoderm relationship: in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2499"} ! Chordata relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0008814 ! pharyngeal arch system relationship: part_of UBERON:8450003 {source="PMID:16313389"} ! embryonic craniocervical region property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png xsd:anyURI property_value: UBPROP:0000001 "One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010359", ontology="AAO", source="NLM:branchial+arch"} property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000155", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "Numbered cranial to caudal. different in mammals. branchial arch = ZFA:0001613 pharyngeal arch 3-7. generally gill arch 1 = pharyngeal arch 3. terminology varies as to whether branchial arch follows gill or pharyngeal numbering" xsd:string [Term] id: UBERON:0002546 name: cranial placode namespace: uberon def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." [http://www.ncbi.nlm.nih.gov/books/NBK53175/, https://github.com/obophenotype/uberon/issues/135, https://github.com/seger/aao/issues/4, https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "cranial placodes" RELATED OMO:0003004 [XAO:0000305] synonym: "ectodermal cranial placode" EXACT [UBERON:cjm] synonym: "ectodermal placode" BROAD INCONSISTENT [FMA:293966, PMID:22512454] synonym: "placode" BROAD [Wikipedia:Placode] xref: AAO:0010466 xref: EFO:0001650 xref: MAT:0000369 xref: MIAA:0000369 xref: XAO:0000305 is_a: UBERON:0005085 {source="cjm"} ! ectodermal placode relationship: in_taxon NCBITaxon:7711 {source="PMID:11523831", source="PMID:22512454"} ! Chordata relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:8450003 ! embryonic craniocervical region property_value: editor_note "Do not merge with neurogenic placode" xsd:string property_value: UBPROP:0000008 "Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons" xsd:string {source="PMID:11523831"} property_value: UBPROP:0000013 "The term placode or placodes also applies to developing organs such as teeth, mammary glands, hair follicles, feathers and scales. We include a separate parent class for this. to avoid confusion, we include neurogenic placode as a subclass" xsd:string [Term] id: UBERON:0002548 name: larva namespace: uberon def: "A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva] subset: uberon_slim synonym: "ammocoete" NARROW [Wikipedia:Larva] synonym: "bipinnaria" NARROW [Wikipedia:Larva] synonym: "caterpillar" NARROW [Wikipedia:Larva] synonym: "glochidium" NARROW [Wikipedia:Larva] synonym: "grub" NARROW [Wikipedia:Larva] synonym: "larval organism" EXACT [TAO:0002048] synonym: "leptocephalus" NARROW [Wikipedia:Larva] synonym: "maggot" NARROW [Wikipedia:Larva] synonym: "naiad" NARROW [Wikipedia:Larva] synonym: "nymph" NARROW [Wikipedia:Larva] synonym: "planula" NARROW [Wikipedia:Larva] synonym: "tadpole" NARROW [Wikipedia:Larva] synonym: "trochophore" NARROW [Wikipedia:Larva] synonym: "veliger" NARROW [Wikipedia:Larva] synonym: "wriggler" NARROW [Wikipedia:Larva] synonym: "zoea" NARROW [Wikipedia:Larva] xref: AEO:0000126 xref: BTO:0000707 xref: FBbt:00001727 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000459 xref: MESH:D007814 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: TAO:0002048 xref: Wikipedia:Larva is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: existence_starts_and_ends_during UBERON:0000069 ! larval stage relationship: existence_starts_and_ends_during UBERON:0000069 ! larval stage relationship: has_quality PATO:0001185 ! larval property_value: editor_note "TODO discriminate between stages and organisms" xsd:string property_value: UBPROP:0000001 "Whole organism that is premetamorphic or a very immature individual.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002048", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000007 "larval" xsd:string [Term] id: UBERON:0002553 name: anatomical cavity namespace: uberon def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [FMA:67552] subset: human_subset subset: mouse_subset subset: upper_level synonym: "cavity" BROAD [] xref: BIRNLEX:1011 xref: EMAPA:37442 {source="MA:th"} xref: FMA:67552 xref: galen:Cavity xref: MA:0002447 xref: NCIT:C34007 is_a: UBERON:0000464 ! anatomical space relationship: location_of UBERON:0000463 ! organism substance [Term] id: UBERON:0002558 name: organ cavity namespace: uberon subset: human_subset subset: mouse_subset subset: upper_level synonym: "cavity of organ" EXACT [FMA:12237] xref: BIRNLEX:1019 xref: FMA:12237 xref: SCTID:362606005 is_a: UBERON:0002553 ! anatomical cavity [Term] id: UBERON:0002561 name: lumen of central nervous system namespace: uberon def: "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." [https://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "cavity of neuraxis" EXACT [FMA:75007] synonym: "cavity of ventricular system of neuraxis" EXACT [FMA:75007] synonym: "neuraxis cavity" EXACT [FMA:75007] synonym: "neuraxis lumen" EXACT [] xref: BIRNLEX:1029 xref: FMA:75007 is_a: UBERON:0002558 ! organ cavity intersection_of: UBERON:0002558 ! organ cavity intersection_of: luminal_space_of UBERON:0001017 ! central nervous system relationship: develops_from UBERON:0003842 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="cjm"} ! neural tube lumen relationship: luminal_space_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system property_value: RO:0002175 NCBITaxon:569425 {source="DOI:10.1186/s12983-014-0089-2"} [Term] id: UBERON:0002616 name: regional part of brain namespace: uberon def: "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." [BIRNLEX:1167] subset: human_subset subset: mouse_subset subset: non_informative synonym: "anatomical structure of brain" EXACT [OBOL:automatic] synonym: "biological structure of brain" EXACT [OBOL:automatic] synonym: "brain anatomical structure" EXACT [OBOL:automatic] synonym: "brain biological structure" EXACT [OBOL:automatic] synonym: "brain part" EXACT [] synonym: "neuraxis segment" EXACT [FMA:55676] synonym: "neuroanatomical region" EXACT [] synonym: "segment of brain" EXACT [BIRNLEX:1167] xref: BIRNLEX:1167 xref: FMA:55676 xref: NCIT:C13031 xref: SCTID:384763002 xref: UMLS:C0445620 {source="ncithesaurus:Brain_Part"} is_a: UBERON:0000073 ! regional part of nervous system intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0000955 ! brain relationship: composed_primarily_of UBERON:0003714 ! neural tissue relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0002726 name: cervical spinal cord namespace: uberon def: "A spinal cord segment that adjacent_to a cervical region." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cervical segment of spinal cord" EXACT [FMA:71166] synonym: "cervical segments of spinal cord [1-8]" EXACT [FMA:71166] synonym: "cervical spinal cord" EXACT [FMA:71166] synonym: "pars cervicalis medullae spinalis" EXACT OMO:0003011 [FMA:71166, FMA:TA] synonym: "segmenta cervicalia medullae spinalis [1-8" EXACT OMO:0003011 [FMA:71166, FMA:TA] xref: BIRNLEX:1499 xref: FMA:71166 xref: MA:0003081 xref: MESH:D066193 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C12892 xref: neuronames:1654 xref: SCTID:180960003 xref: UMLS:C0581619 {source="BIRNLEX:1499", source="ncithesaurus:Cervical_Spinal_Cord"} xref: UMLS:C1278837 {source="BIRNLEX:1499"} is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: adjacent_to UBERON:0005434 ! cervical region relationship: adjacent_to UBERON:0005434 ! cervical region relationship: in_taxon NCBITaxon:8287 ! Sarcopterygii property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002925 name: trigeminal nucleus namespace: uberon def: "A nucleus of brain that is part of a trigeminal nuclear complex." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "nucleus mesencephalicus nervi trigemini" RELATED [BTO:0001074] synonym: "nucleus mesencephalicus trigeminalis" RELATED [BTO:0001074] synonym: "nucleus of trigeminal nuclear complex" EXACT [FMA:71247] synonym: "nucleus tractus mesencephali nervi trigeminalis" RELATED [BTO:0001074] synonym: "trigeminal nuclear complex nucleus" EXACT [FMA:71247] synonym: "trigeminal nucleus" EXACT [FMA:71248] synonym: "trigeminal V nucleus" EXACT [MA:0001028] xref: BM:V xref: BTO:0001074 xref: CALOHA:TS-2077 xref: EMAPA:35883 xref: EV:0100271 xref: FMA:71247 xref: GAID:604 xref: http://uri.neuinfo.org/nif/nifstd/nifext_11 xref: MA:0001028 xref: MESH:D014278 xref: NCIT:C12807 xref: SCTID:280164007 xref: UMLS:C0040999 {source="ncithesaurus:Trigeminal_Nucleus"} xref: VHOG:0001353 is_a: UBERON:0000126 ! cranial nerve nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: part_of UBERON:0007641 ! trigeminal nuclear complex relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: part_of UBERON:0007641 ! trigeminal nuclear complex property_value: UBPROP:0000012 "massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA." xsd:string {external_ontology="GO", url="https://github.com/obophenotype/mouse-anatomy-ontology/issues/58"} [Term] id: UBERON:0003023 name: pontine tegmentum namespace: uberon def: "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." [BIRNLEX:923] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "dorsal pons" EXACT [] synonym: "dorsal portion of pons" EXACT [FMA:71108] synonym: "pars dorsalis pontis" RELATED OMO:0003011 [NeuroNames:557] synonym: "pars posterior pontis" RELATED OMO:0003011 [NeuroNames:557] synonym: "tegmental portion of pons" EXACT [FMA:71108] synonym: "tegmentum of pons" EXACT [FMA:71108] synonym: "tegmentum pontis" EXACT OMO:0003011 [FMA:71108, FMA:TA] synonym: "tegmentum pontis" RELATED OMO:0003011 [Wikipedia:Pontine_tegmentum] xref: BAMS:PTg xref: BIRNLEX:923 xref: DHBA:12416 xref: FMA:71108 xref: HBA:9135 xref: MESH:D065821 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: neuronames:557 {source="BIRNLEX:923"} xref: SCTID:362401009 xref: UMLS:C0228426 {source="BIRNLEX:923"} xref: Wikipedia:Pontine_tegmentum is_a: UBERON:0000064 ! organ part relationship: has_part UBERON:0002047 ! pontine raphe nucleus relationship: has_part UBERON:0002128 ! superior olivary complex relationship: has_part UBERON:0002148 ! locus ceruleus relationship: has_part UBERON:0002149 ! superior salivatory nucleus relationship: part_of UBERON:0000988 ! pons property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum]" xsd:string [Term] id: UBERON:0003037 name: septum namespace: uberon def: "A wall, dividing a cavity or structure into smaller ones[WP]." [Wikipedia:Septum] comment: general anatomical term in FMA subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "septa" EXACT OMO:0003004 [] xref: AAO:0011127 xref: FMA:86461 xref: Wikipedia:Septum is_a: UBERON:0000061 ! anatomical structure relationship: located_in UBERON:0002553 ! anatomical cavity property_value: UBPROP:0000007 "septal" xsd:string [Term] id: UBERON:0003038 name: thoracic spinal cord namespace: uberon def: "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." [Wikipedia:Thoracic_spinal_cord] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "pars thoracica medullae spinalis" EXACT OMO:0003011 [FMA:71167, FMA:TA] synonym: "segmenta thoracica medullae spinalis [1-12]" EXACT OMO:0003011 [FMA:71167, FMA:TA] synonym: "thoracic region of spinal cord" EXACT [FMA:71167] synonym: "thoracic segment of spinal cord" EXACT [FMA:71167] synonym: "thoracic segments of spinal cord [1-12]" EXACT [FMA:71167] synonym: "thoracic spinal cord" EXACT [FMA:71167] xref: BIRNLEX:966 xref: FMA:71167 xref: MA:0003082 xref: NCIT:C12894 xref: neuronames:1718 xref: SCTID:278750009 xref: UMLS:C0581620 {source="ncithesaurus:Thoracic_Spinal_Cord", source="BIRNLEX:966"} xref: Wikipedia:Thoracic_spinal_cord is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0008231 ! dorsal thoracic segment of trunk property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003052 name: midbrain-hindbrain boundary namespace: uberon def: "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." [GO:0021555] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "isthmic organizer territory" RELATED [XAO:0000016] synonym: "isthmo-cerebellar region" RELATED [VHOG:0000649] synonym: "isthmus" RELATED [] synonym: "isthmus/MHB" RELATED [Geisha:syn, NCBITaxon:8782] synonym: "MHB" EXACT [] synonym: "mid-hindbrain boundary" EXACT [] synonym: "mid-hindbrain junction" EXACT [] synonym: "midbrain hindbrain boundary" EXACT [] xref: AAO:0011064 xref: DMBA:16810 xref: EHDAA2:0004395 xref: EHDAA:5789 xref: EMAPA:32857 xref: NCIT:C93172 xref: neuronames:2076 xref: TAO:0000042 xref: VHOG:0000649 xref: XAO:0000016 xref: ZFA:0000042 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 {inconsistent_with="ZFA", source="https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/106/"} ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: overlaps UBERON:0001891 ! midbrain intersection_of: overlaps UBERON:0002028 ! hindbrain relationship: develops_from UBERON:0003075 ! neural plate relationship: develops_from UBERON:0009615 ! midbrain hindbrain boundary neural plate relationship: immediate_transformation_of UBERON:0009615 {source="ZFA"} ! midbrain hindbrain boundary neural plate relationship: overlaps UBERON:0001891 ! midbrain relationship: overlaps UBERON:0002028 ! hindbrain relationship: part_of UBERON:0000955 {source="ZFA"} ! brain property_value: editor_note "consider adding class for organizer. Consider adding separate class for isthmus as a structure" xsd:string property_value: UBPROP:0000003 "Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000649", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003055 name: periderm namespace: uberon def: "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm." [ISBN:9780878932504, PMID:25133425, PMID:35582825] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "enveloping layer" RELATED [ZFA:0001185] synonym: "epitrichium" RELATED [MP:0013530, PMID:28722897] synonym: "EVL" RELATED OMO:0003000 [ZFA:0001185] xref: BTO:0003377 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EHDAA2:0001846 xref: EHDAA:6538 xref: FMA:295662 xref: NCIT:C34247 xref: TAO:0001185 xref: UMLS:C1518973 {source="ncithesaurus:Periderm"} xref: VHOG:0001680 xref: XAO:0000029 xref: ZFA:0001185 is_a: UBERON:0000487 {source="EHDAA2"} ! simple squamous epithelium is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure property_value: UBPROP:0000001 "The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001185", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001185", ontology="TAO"} property_value: UBPROP:0000008 "In humans, the periderm is a monolayer and is shed prenatally." xsd:string {xref="PMID:35582825"} property_value: UBPROP:0000008 "In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP]" xsd:string {xref="PMID:35582825"} property_value: UBPROP:0000008 "In mice, the periderm is bilayered. It consists of the outer layer, which possesses numerous microvilli, and the inner layer that develops specific periderm granules. Both layers can be well recognized as early as at E14.5 and they are shed at different time points: the outer layer is shed in utero, in conjunction with barrier acquisition (E16-18), while the inner layer is retained postnatally." xsd:string property_value: UBPROP:0000011 "In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis" xsd:string property_value: UBPROP:0000011 "Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html)" xsd:string [Term] id: UBERON:0003056 name: pre-chordal neural plate namespace: uberon def: "The portion of neural plate anterior to the mid-hindbrain junction." [XB:curator] subset: human_subset subset: mouse_subset synonym: "anterior neural plate" RELATED [] xref: AAO:0011084 xref: TAO:0007016 xref: VHOG:0001200 xref: XAO:0000045 xref: ZFA:0007016 is_a: UBERON:0005291 ! embryonic tissue relationship: anterior_to UBERON:0009615 ! midbrain hindbrain boundary neural plate relationship: part_of UBERON:0003075 ! neural plate property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001200", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003057 name: chordal neural plate namespace: uberon def: "The portion of neural plate posterior to the mid-hindbrain junction." [XB:curator] subset: human_subset subset: mouse_subset synonym: "posterior neural plate" RELATED [] xref: TAO:0007017 xref: VHOG:0001201 xref: XAO:0000046 xref: ZFA:0007017 is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0003075 ! neural plate relationship: posterior_to UBERON:0009615 ! midbrain hindbrain boundary neural plate property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001201", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003059 name: presomitic mesoderm namespace: uberon def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." [ZFIN:curator] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "presumptive somite mesoderm" RELATED [] synonym: "PSM" RELATED [] synonym: "segmental plate" EXACT [] synonym: "somitogenic mesoderm" RELATED [] synonym: "somitomeric mesoderm" RELATED [GO:0002075] synonym: "unsegmented mesenchyme" RELATED [VHOG:0000559] synonym: "unsegmented paraxial mesoderm" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AAO:0011086 xref: EFO:0001982 xref: EMAPA:16189 xref: EMAPA:16752 xref: TAO:0000279 xref: VHOG:0000559 xref: XAO:0000057 xref: ZFA:0000279 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: has_potential_to_develop_into UBERON:0002329 ! somite intersection_of: immediate_transformation_of UBERON:0007282 ! presumptive segmental plate relationship: develops_from UBERON:0000922 ! embryo relationship: develops_from UBERON:0007282 ! presumptive segmental plate relationship: has_potential_to_develop_into UBERON:0002329 ! somite relationship: immediate_transformation_of UBERON:0007282 {source="Bgee:AN"} ! presumptive segmental plate relationship: part_of UBERON:0003077 ! paraxial mesoderm property_value: UBPROP:0000001 "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000279", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000559", ontology="VHOG", source="DOI:10.1006/dbio.2001.0460 Schubert M, Holland LZ, Dale Stokes M and Holland ND, Three Amphoxius Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates. Developmental Biology (2001)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003061 name: blood island namespace: uberon def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." [Wikipedia:Blood_island_of_umbilical_vesicle] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blood islands" EXACT OMO:0003004 [] synonym: "caudal hematopoietic tissue" RELATED [] synonym: "posterior blood island" RELATED [] synonym: "posterior ICM" RELATED [] synonym: "VBI" RELATED [] synonym: "ventral blood island" RELATED [] synonym: "ventral lateral plate mesoderm" BROAD [] xref: AAO:0011006 xref: EFO:0003489 xref: EHDAA:207 xref: NCIT:C34113 xref: TAO:0000094 xref: TE:E5.11.2.0.0.0.4 xref: UMLS:C1511224 {source="ncithesaurus:Blood_Island"} xref: VHOG:0000085 xref: Wikipedia:Blood_island_of_umbilical_vesicle xref: XAO:0000067 xref: ZFA:0000094 is_a: UBERON:0006598 ! presumptive structure relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: has_potential_to_develop_into UBERON:0002390 ! hematopoietic system property_value: UBPROP:0000001 "Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000094", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011006", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000002 "relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000094", ontology="TAO"} property_value: UBPROP:0000003 "Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000085", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.450, DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0003063 name: prechordal plate namespace: uberon alt_id: UBERON:0004881 def: "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." [ISBN:0838580343, MP:0004387] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "head mesenchyme" BROAD [XAO:0000079] synonym: "head mesoderm" BROAD [XAO:0000079] xref: AAO:0011085 xref: EHDAA2:0001493 xref: EHDAA:181 xref: FMA:295532 xref: TAO:0000060 xref: VHOG:0000086 xref: Wikipedia:Prechordal_plate xref: XAO:0000079 xref: ZFA:0000060 is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0034878 ! prechordal mesoderm relationship: part_of UBERON:0003068 {source="ZFA"} ! axial mesoderm relationship: transformation_of UBERON:0034878 {todo="PMID:16313393"} ! prechordal mesoderm property_value: editor_note "TODO - check; developmental relationship to anterior hypoblast in ZFA?" xsd:string property_value: UBPROP:0000001 "Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000060", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000086", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000086", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00073.x Neidert AH, Panopoulou G and Langeland JA, Amphioxus goosecoid and the evolution of the head organizer and prechordal plate. Evolution and Development (2008)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003064 name: intermediate mesoderm namespace: uberon def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:curators, Wikipedia:Intermediate_mesoderm] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "IM" RELATED [] synonym: "intermediate mesenchyme" RELATED [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "intermediate plate" RELATED [EMAPA:16178] synonym: "intermediate plate mesoderm" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "mesenchyma intermedium" RELATED OMO:0003011 [Wikipedia:Intermediate_mesoderm] xref: AAO:0010575 xref: EMAPA:16056 xref: EMAPA:16178 xref: FMA:293147 xref: NCIT:C34193 xref: SCTID:361476001 xref: TAO:0001206 xref: UMLS:C1284010 {source="ncithesaurus:Intermediate_Mesoderm"} xref: VHOG:0000087 xref: Wikipedia:Intermediate_mesoderm xref: XAO:0000085 xref: ZFA:0001206 is_a: UBERON:0002050 ! embryonic structure relationship: adjacent_to UBERON:0003077 ! paraxial mesoderm relationship: adjacent_to UBERON:0003081 ! lateral plate mesoderm relationship: develops_from UBERON:0000926 {source="XAO"} ! mesoderm relationship: part_of UBERON:0000926 {source="AAO"} ! mesoderm relationship: part_of UBERON:0005256 {source="EMAPA"} ! trunk mesenchyme property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010575", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "(...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000087", ontology="VHOG", source="Wikipedia:Mesoderm, ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.43", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm')." xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0003067 name: dorsolateral placode namespace: uberon def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." [ZFIN:curator] comment: The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode subset: human_subset subset: mouse_subset synonym: "dorsolateral placodes" EXACT OMO:0003004 [ZFA:0001310] xref: TAO:0001310 xref: VHOG:0000103 xref: XAO:0000187 xref: ZFA:0001310 is_a: UBERON:0009955 {source="NCBIBook:NBK53175"} ! neurogenic placode relationship: dorsal_to UBERON:0003078 ! epibranchial placode property_value: UBPROP:0000003 "In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000103", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003068 name: axial mesoderm namespace: uberon def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GO:0048318, Wikipedia:Chordamesoderm] subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "chordamesoderm" RELATED [Wikipedia:Chordamesoderm] xref: AAO:0011017 xref: EFO:0003647 xref: TAO:0001204 xref: VHOG:0000107 xref: Wikipedia:Chordamesoderm xref: XAO:0000205 xref: ZFA:0001204 is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000926 ! mesoderm relationship: in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0000926 ! mesoderm property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003070 name: trigeminal placode complex namespace: uberon def: "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/693, PMID:22512454] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "profundus placode" RELATED INCONSISTENT [ISBN:0471888893] synonym: "profundus V placode" RELATED INCONSISTENT [ISBN:0471888893] synonym: "trigeminal placode" EXACT [EHDAA2:0004209, VHOG:0000109, XAO:0000225, ZFA:0000162] synonym: "trigeminal placodes" RELATED OMO:0003004 [ZFA:0000162] synonym: "trigeminal V placode" EXACT [] xref: EFO:0003433 xref: EHDAA2:0004209 xref: TAO:0000162 xref: VHOG:0000109 xref: XAO:0000225 xref: ZFA:0000162 is_a: UBERON:0003067 {source="ISBN:0471888893"} ! dorsolateral placode relationship: has_potential_to_developmentally_contribute_to UBERON:0003942 ! somatosensory system property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/ANiknejad property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/mellybelly property_value: UBPROP:0000001 "The ectodermal precursor of the trigeminal ganglion. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24.[XAO]" xsd:string {ontology="XAO"} property_value: UBPROP:0000001 "The ectodermal rudiment of the trigeminal ganglion, distinguishable during much of the segmentation period. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000162", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The dorsolateral placodes (trigeminal and vestibular) develop from ectoderm lateral to the brain (...). In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000109", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "Consider naming this 'trigeminal placode complex'. Also, Fig9-5 of ISBN:0471888893 calls this the profundus placode; XAO says 'profundal and the trigeminal ganglia are separate distally but fused at their proximal end...'" xsd:string [Term] id: UBERON:0003071 name: eye primordium namespace: uberon alt_id: UBERON:0005060 def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." [GO:0046619, ZFA:0000570] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "eye anlage" RELATED [XAO:0000227] synonym: "eye field" RELATED [] synonym: "eye placode" EXACT [OBOL:automatic] synonym: "occular primordium" EXACT [] synonym: "ocular primordium" EXACT [] synonym: "optic field" RELATED [] synonym: "optic placode" EXACT [GO:0046619] synonym: "optic placode of camera-type eye" EXACT [GO:0046619, https://orcid.org/0000-0002-6601-2165] synonym: "optic placodes" RELATED OMO:0003004 [] synonym: "optic primordium" EXACT [] xref: AAO:0011038 xref: EFO:0003541 xref: EHDAA2:0004431 xref: TAO:0000570 xref: XAO:0000227 xref: XAO:0004090 xref: ZFA:0000570 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0001048 ! primordium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: has_potential_to_develop_into UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0003056 ! pre-chordal neural plate relationship: has_potential_to_develop_into UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0003056 {source="PMID:16496288", source="XAO"} ! pre-chordal neural plate property_value: UBPROP:0000012 "TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium." xsd:string {external_ontology="GO"} [Term] id: UBERON:0003072 name: optic cup namespace: uberon def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." [MP:0004269, Wikipedia:Optic_cup_(embryology), ZFA:0001202] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "eye cup" RELATED [] synonym: "eyecup" RELATED [BTO:0005351] synonym: "ocular cup" RELATED [VHOG:0000167] synonym: "ophtalmic cup" RELATED [BTO:0005351] xref: BTO:0005351 xref: EHDAA2:0001303 xref: EHDAA:2912 xref: EMAPA:16674 xref: NCIT:C34233 xref: SCTID:308789007 xref: TAO:0001202 xref: UMLS:C0231109 {source="ncithesaurus:Optic_Cup"} xref: VHOG:0000167 xref: ZFA:0001202 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: developmentally_induced_by UBERON:0003073 ! lens placode relationship: develops_from UBERON:0004128 {source="ZFA"} ! optic vesicle relationship: part_of NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000167", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003073 name: lens placode namespace: uberon def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." [Wikipedia:Lens_placode, ZFIN:curator] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lens placodes" RELATED OMO:0003004 [ZFA:0000122] synonym: "placoda lentis" RELATED OMO:0003011 [Wikipedia:Lens_placode] xref: AAO:0011055 xref: EFO:0003494 xref: EHDAA2:0000982 xref: EHDAA:2908 xref: EMAPA:16672 xref: FMA:296767 xref: NCIT:C34202 xref: TAO:0000122 xref: UMLS:C1517770 {source="ncithesaurus:Lens_Placodes"} xref: VHOG:0000166 xref: Wikipedia:Lens_placode xref: XAO:0000240 xref: ZFA:0000122 is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: has_potential_to_develop_into UBERON:0000965 ! lens of camera-type eye relationship: developmentally_induced_by UBERON:0004128 ! optic vesicle relationship: has_potential_to_develop_into UBERON:0000965 ! lens of camera-type eye relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png xsd:anyURI property_value: UBPROP:0000001 "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000122", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" xsd:string {source="NCBIBook:NBK53175"} [Term] id: UBERON:0003075 name: neural plate namespace: uberon def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." [ISBN:0815318960, OMD:neural+plate, Wikipedia:Neural_plate, ZFIN:curator] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lamina neuralis" RELATED OMO:0003011 [Wikipedia:Neural_plate] synonym: "presumptive central nervous system" RELATED [] xref: AAO:0011072 xref: BTO:0001765 xref: DHBA:10153 xref: DMBA:15565 xref: EHDAA:346 xref: EHDAA:902 xref: EMAPA:35593 xref: FMA:293879 xref: MESH:D054258 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C34225 xref: neuronames:1362 xref: RETIRED_EHDAA2:0001252 xref: TAO:0000132 xref: UMLS:C0920623 {source="ncithesaurus:Neural_Plate"} xref: VHOG:0000068 xref: Wikipedia:Neural_plate xref: XAO:0000249 xref: ZFA:0000132 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord relationship: develops_from UBERON:0004734 ! gastrula relationship: develops_from UBERON:0007284 ! presumptive neural plate relationship: develops_from UBERON:0016880 ! future nervous system relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate relationship: in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png xsd:anyURI property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003076 name: posterior neural tube namespace: uberon subset: human_subset subset: mouse_subset xref: AAO:0011082 xref: TAO:0007037 xref: VHOG:0001383 xref: XAO:0000250 xref: ZFA:0007037 is_a: UBERON:0002050 ! embryonic structure disjoint_from: UBERON:0003080 {source="lexical"} ! anterior neural tube relationship: develops_from UBERON:0003057 ! chordal neural plate relationship: part_of UBERON:0001049 ! neural tube property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001383", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003077 name: paraxial mesoderm namespace: uberon def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." [GO:0048339, https://github.com/obophenotype/uberon/issues/30] subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "mesoderma paraxiale" RELATED OMO:0003011 [Wikipedia:Paraxial_mesoderm] synonym: "paraxial mesenchyme" EXACT [https://github.com/obophenotype/uberon/issues/30, https://github.com/obophenotype/uberon/wiki/The-neural-crest, ZFA:0000255] synonym: "somitic mesoderm" EXACT [ISBN:9780878932504] xref: AAO:0010568 xref: EFO:0003515 xref: EMAPA:16183 xref: EMAPA:16751 xref: FMA:293145 xref: NCIT:C34244 xref: SCTID:361475002 xref: TAO:0000255 xref: UMLS:C1284009 {source="ncithesaurus:Paraxial_Mesoderm"} xref: VHOG:0000114 xref: Wikipedia:Paraxial_mesoderm xref: XAO:0000259 xref: ZFA:0000255 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue is_a: UBERON:0015212 ! lateral structure relationship: develops_from UBERON:0000307 ! blastula relationship: develops_from UBERON:0007285 ! presumptive paraxial mesoderm relationship: existence_starts_during UBERON:0000109 ! gastrula stage relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm relationship: in_lateral_side_of UBERON:0000922 ! embryo property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0003078 name: epibranchial placode namespace: uberon def: "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." [VHOG:0000117] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "epibranchial placodes" EXACT OMO:0003004 [ZFA:0001294] synonym: "ventrolateral placode" RELATED [ISBN:0471888893] xref: AAO:0011036 xref: EFO:0003455 xref: FMA:293968 xref: TAO:0001294 xref: VHOG:0000117 xref: XAO:0000284 xref: ZFA:0001294 is_a: UBERON:0009955 {source="NCBIBook:NBK53175", source="ZFA"} ! neurogenic placode relationship: develops_from UBERON:0000076 {source="EHDAA2-abduced"} ! external ectoderm relationship: has_potential_to_developmentally_contribute_to UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0000010 {source="ZFA"} ! peripheral nervous system property_value: UBPROP:0000001 "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. [Graham_A, The_development_and_evolution_of_the_pharyngeal_arches._J_Anat_(2001)_199:_133-141][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000117", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000117", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A, The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "Epibranchial placodes-derived neurons innervate internal organs to transmit information such as heart rate, blood pressure, and visceral distension from the periphery to the central nervous system (Baker and Bronner-Fraser, 2001). From rostral to caudal the epibranchial placodes comprise the geniculate, petrosal, and nodose placodes, each associated in sequence with the first, second and third branchial clefts. Each placode contributes sensory neurons to cranial nerves VII (facial nerve), IX (glossopharyngeal nerve), and X (vagal nerve), respectively" xsd:string {source="NCBIBook:NBK53175"} property_value: UBPROP:0000012 "in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group" xsd:string {external_ontology="XAO"} [Term] id: UBERON:0003080 name: anterior neural tube namespace: uberon subset: human_subset subset: mouse_subset xref: AAO:0011012 xref: TAO:0007038 xref: VHOG:0001384 xref: XAO:0000307 xref: ZFA:0007038 is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0003056 ! pre-chordal neural plate relationship: part_of UBERON:0001049 ! neural tube property_value: editor_note "TODO - add grouping class for the anterior end of the neural tube at all stages" xsd:string property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001384", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003081 name: lateral plate mesoderm namespace: uberon alt_id: UBERON:0006258 def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." [MP:0010117, Wikipedia:Lateral_plate_mesoderm] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "lateral mesoderm" EXACT [GO:0048368] synonym: "lateral plate" RELATED [] synonym: "lateral plate mesenchyme" RELATED [EHDAA2:0000919] synonym: "LPM" EXACT OMO:0003000 [ZFA:0000121] synonym: "mesoderma laminae lateralis" RELATED OMO:0003011 [Wikipedia:Lateral_plate_mesoderm] xref: AAO:0010574 xref: EHDAA2:0000919 xref: EHDAA:379 xref: EMAPA:16179 xref: FMA:293149 xref: NCIT:C34199 xref: SCTID:361477005 xref: TAO:0000121 xref: UMLS:C1517749 {source="ncithesaurus:Lateral_Mesoderm"} xref: VHOG:0000118 xref: Wikipedia:Lateral_plate_mesoderm xref: XAO:0000311 xref: ZFA:0000121 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm relationship: surrounds UBERON:0003887 ! intraembryonic coelom property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png xsd:anyURI property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "subclass of mesoderm in ZFA." xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0003082 name: myotome namespace: uberon def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:0001018] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle plate" RELATED [] synonym: "myomere" RELATED [] synonym: "myomeres" EXACT OMO:0003004 [TAO:0001056] synonym: "myotome region" RELATED [] synonym: "myotomes" RELATED [] synonym: "myotomus" RELATED OMO:0003011 [Wikipedia:Myotome] xref: AAO:0011067 xref: AEO:0001018 xref: BTO:0000742 xref: EHDAA2_RETIRED:0003431 xref: EHDAA:1721 xref: EHDAA:1727 xref: EHDAA:1733 xref: EHDAA:1739 xref: EMAPA:32841 xref: FMA:295658 xref: NCIT:C34214 xref: SCTID:344535001 xref: TAO:0001056 xref: UMLS:C1513802 {source="ncithesaurus:Myotome_Region"} xref: VHOG:0001244 xref: Wikipedia:Myotome xref: XAO:0000315 xref: ZFA:0001056 is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure relationship: contributes_to_morphology_of UBERON:0001630 ! muscle organ relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome property_value: editor_note "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png xsd:anyURI property_value: UBPROP:0000001 "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001056", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001244", ontology="VHOG", source="DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003083 name: trunk neural crest namespace: uberon def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." [ISBN:0815318960, Wikipedia:Trunk_neural_crest] subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "TNC" EXACT OMO:0003000 [XAO:0000319] synonym: "trunk crest" RELATED [] xref: AAO:0010582 xref: EFO:0003605 xref: EHDAA2:0001901 xref: TAO:0001024 xref: VHOG:0000062 xref: Wikipedia:Trunk_neural_crest xref: XAO:0000319 xref: ZFA:0001024 is_a: UBERON:0005291 ! embryonic tissue relationship: has_part CL:0000011 {source="ZFA"} ! migratory trunk neural crest cell relationship: part_of UBERON:0002342 ! neural crest property_value: UBPROP:0000001 "Post-cranial portion of the neural crest. Exact anatomical derivations not experimentally resolved in amphibians.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010582", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000062", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003084 name: heart primordium namespace: uberon def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." [ZFIN:curator] subset: human_subset subset: mouse_subset subset: uberon_slim synonym: "cardiac field" RELATED [ZFA:0000028] synonym: "fused heart primordium" RELATED [] xref: AAO:0011044 xref: BTO:0001887 xref: NCIT:C34276 xref: TAO:0000028 xref: UMLS:C1514450 {source="ncithesaurus:Primordium_of_the_Heart"} xref: XAO:0000336 xref: ZFA:0000028 is_a: UBERON:0001048 {source="Obol"} ! primordium relationship: develops_from UBERON:0003081 {source="ZFA"} ! lateral plate mesoderm relationship: develops_from UBERON:0004140 ! primary heart field relationship: develops_from UBERON:0007005 {source="XAO"} ! cardiogenic splanchnic mesoderm relationship: part_of UBERON:0004535 {source="ZFA"} ! cardiovascular system property_value: editor_note "should probably be merged with heart rudiment." xsd:string property_value: UBPROP:0000001 "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000028", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011044", ontology="AAO", source="XAO:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000028", ontology="TAO"} [Term] id: UBERON:0003086 name: caudal artery namespace: uberon def: "Extension of the dorsal aorta in the tail." [Wikipedia:Caudal_artery, ZFIN:curator] subset: efo_slim subset: mouse_subset subset: uberon_slim synonym: "CA" RELATED [] xref: AAO:0011023 xref: EFO:0003472 xref: TAO:0000011 xref: VHOG:0000123 xref: Wikipedia:Caudal_artery xref: XAO:0000364 xref: ZFA:0000011 is_a: UBERON:0001637 ! artery is_a: UBERON:0003524 ! tail blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: connecting_branch_of UBERON:0005805 ! dorsal aorta intersection_of: part_of UBERON:0007812 ! post-anal tail relationship: connecting_branch_of UBERON:0005805 ! dorsal aorta relationship: part_of RO:0002577 ! system relationship: part_of UBERON:2001073 ! axial vasculature property_value: UBPROP:0000001 "Extension of the dorsal aorta in the tail. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000011", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The posterior extension of the dorsal aorta to the tail region, which degenerates at metamorphosis.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011023", ontology="AAO", source="ISBN:0-226-55763-4"} [Term] id: UBERON:0003089 name: sclerotome namespace: uberon def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." [https://github.com/obophenotype/uberon/issues/316, Wikipedia:Sclerotome, XB:curator] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "sclerotomes" EXACT OMO:0003004 [TAO:0001080] synonym: "sclerotomus" RELATED OMO:0003011 [Wikipedia:Sclerotome] xref: AAO:0010571 xref: AEO:0000212 xref: BTO:0006255 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EHDAA2:0003439 xref: EMAPA:31159 xref: FMA:295652 xref: NCIT:C34287 xref: TAO:0001080 xref: UMLS:C0183176 {source="ncithesaurus:Sclerotome"} xref: VHOG:0000680 xref: Wikipedia:Sclerotome xref: XAO:0000397 xref: ZFA:0001080 is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite relationship: in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png xsd:anyURI property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"} [Term] id: UBERON:0003099 name: cranial neural crest namespace: uberon def: "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." [MGI:anna] subset: efo_slim subset: human_subset subset: mouse_subset subset: uberon_slim subset: vertebrate_core synonym: "cephalic neural crest" EXACT [EMAPA:16091] synonym: "CNC" EXACT OMO:0003000 [XAO:0001001] synonym: "cranial NCC population" EXACT [] synonym: "crista neuralis cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_neural_crest] synonym: "head crest" RELATED [] synonym: "head NCC population" EXACT [] synonym: "head neural crest" RELATED [] xref: AAO:0010580 xref: EFO:0003645 xref: EHDAA2:0004420 xref: EMAPA:16091 xref: TAO:0001194 xref: VHOG:0000063 xref: Wikipedia:Cranial_neural_crest xref: XAO:0001001 xref: ZFA:0001194 is_a: UBERON:0005291 ! embryonic tissue relationship: has_part CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0002342 ! neural crest property_value: UBPROP:0000001 "Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010580", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Neural crest that is part of the head.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001194", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000063", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003100 name: female organism namespace: uberon def: "Gonochoristic organism that can produce female gametes." [CARO:0000028] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "female" RELATED [TAO:0000303] synonym: "female human body" NARROW SENSU [FMA:67812] xref: AAO:0010030 xref: BILA:0000028 xref: CARO:0000028 xref: FBbt:00007011 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67812 xref: HAO:0000028 xref: SCTID:362608006 xref: TAO:0000303 xref: TGMA:0001839 xref: XAO:0003005 xref: ZFA:0000303 is_a: UBERON:0000468 ! multicellular organism property_value: RO:0002171 UBERON:0003101 [Term] id: UBERON:0003102 name: surface structure namespace: uberon def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/24] subset: human_subset subset: mouse_subset subset: upper_level synonym: "anatomical surface feature" EXACT [EHDAA2:0003010] synonym: "surface feature" RELATED [] synonym: "surface region" RELATED [] synonym: "surface structures" RELATED OMO:0003004 [ZFA:0000292] xref: AAO:0010337 xref: AEO_RETIRED:0000010 xref: EHDAA2_RETIRED:0003010 xref: galen:SurfaceRegion xref: TAO:0000292 xref: VSAO:0000001 xref: Wikipedia:Surface_structure xref: XAO:0003028 xref: ZFA:0000292 is_a: UBERON:0000061 ! anatomical structure relationship: adjacent_to UBERON:0013514 ! space surrounding organism property_value: editor_note "consider obsoleting. See issue/1305" xsd:string property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/wdahdul property_value: UBPROP:0000001 "Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000292", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0003103 name: compound organ namespace: uberon def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:0000024] subset: human_subset subset: mouse_subset subset: organ_slim subset: upper_level synonym: "organ" RELATED [] xref: AAO:0010015 xref: AEO:0000024 xref: BILA:0000024 xref: CARO:0000024 xref: EHDAA2:0003024 xref: HAO:0000024 xref: TADS:0000598 xref: TAO:0000496 xref: TGMA:0001837 xref: VHOG:0001723 xref: XAO:0003041 xref: ZFA:0000496 is_a: UBERON:0000062 ! organ property_value: IAO:0000232 "this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs" xsd:string [Term] id: UBERON:0003104 name: mesenchyme namespace: uberon def: "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." [https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up, https://en.wikipedia.org/wiki/Mesenchyme, https://github.com/obophenotype/uberon/issues/1641] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mesenchyma" RELATED OMO:0003011 [Wikipedia:Mesenchyme] synonym: "mesenchymal tissue" EXACT [] synonym: "mesenchyme tissue" EXACT [] synonym: "portion of mesenchymal tissue" EXACT [] synonym: "portion of mesenchyme tissue" EXACT [] xref: AAO:0010427 xref: AEO:0000145 xref: BTO:0001393 xref: CALOHA:TS-0620 xref: EHDAA2:0003145 xref: EV:0100007 xref: NCIT:C13301 xref: TAO:0000393 xref: UMLS:C0162415 {source="ncithesaurus:Mesenchyme"} xref: VHOG:0000170 xref: Wikipedia:Mesenchyme xref: XAO:0003046 xref: ZFA:0000393 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell relationship: composed_primarily_of CL:0008019 ! mesenchymal cell relationship: functionally_related_to GO:0032502 ! developmental process relationship: has_developmental_contribution_from UBERON:0000926 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! mesoderm relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg xsd:anyURI property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000007 "mesenchymal" xsd:string [Term] id: UBERON:0003112 name: olfactory region namespace: uberon def: "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." [TAO:0000351] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "ethmoid region" RELATED [ZFA:0000351] xref: AAO:0010206 xref: EFO:0003525 xref: NCIT:C98765 xref: TAO:0000351 xref: XAO:0003172 xref: ZFA:0000351 is_a: UBERON:0034921 ! multi organ part structure relationship: part_of UBERON:0001703 ! neurocranium relationship: part_of UBERON:0002241 ! chondrocranium property_value: UBPROP:0000001 "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the peripheral olfactory organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000351", ontology="TAO", source="TAO:MAH"} property_value: UBPROP:0000001 "Anatomical cluster that is located in the anterior region of the neurocranium and provides structural support for the olfactory organs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010206", ontology="AAO", source="AAO:EJS"} [Term] id: UBERON:0003113 name: dermatocranium namespace: uberon def: "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." [Wikipedia:Skull_roof, ZFA:0000863] subset: human_subset subset: mouse_subset synonym: "dendrocranium" EXACT [TAO:0000863] synonym: "dermal bone cranium" RELATED [ZFA:0000863] synonym: "dermal part of skull" RELATED [] synonym: "dermal skull bones" RELATED [] synonym: "dermal skull roof" NARROW [PMID:11523816, Wikipedia:Skull_roof] synonym: "dermatocranial cover" NARROW [] synonym: "exocranium" EXACT [UBERONREF:0000007] synonym: "roof of skull" NARROW [Wikipedia:Skull_roof] synonym: "roofing bones of the skull" RELATED [Wikipedia:Skull_roof] synonym: "skull exoskeleton" RELATED [] synonym: "skull roof" NARROW [PMID:11523816, Wikipedia:Skull_roof] xref: AAO:0010154 xref: TAO:0000863 xref: VHOG:0001665 xref: Wikipedia:Skull_roof xref: XAO:0003169 xref: ZFA:0000863 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0010364 ! dermal skeleton property_value: editor_note "wikipedia treats skull roof and dermatocranium as synonymous, but some sources treat the roof as being part of the dermatocranium - see UBERONREF:0000007" xsd:string property_value: RO:0002161 NCBITaxon:7777 {source="ISBN:0073040584"} property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium and composed of dermally derived bones.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000863", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium which consists of dermally derived bones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010154", ontology="AAO", source="AAO:BJB"} [Term] id: UBERON:0003115 name: pharyngeal arch 4 namespace: uberon def: "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." [MP:0006340] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "4th arch" RELATED [EHDAA2:0000086] synonym: "4th branchial arch" EXACT SENSU [] synonym: "4th pharyngeal arch" EXACT [] synonym: "4th visceral arch" EXACT [] synonym: "branchial arch 2" RELATED SENSU [AAO:0010366, ZFA:0001607] synonym: "fourth pharyngeal arch" EXACT [] synonym: "fourth visceral arch" RELATED [VHOG:0000299] synonym: "gill arch 2" EXACT SENSU [ZFA:0001607] synonym: "second branchial arch" RELATED SENSU [ZFA:0001607] synonym: "second gill arch" EXACT SENSU [ZFA:0001607] synonym: "visceral arch 4" EXACT [] xref: AAO:0010366 xref: EHDAA2:0000086 xref: EHDAA:1663 xref: EMAPA:16760 xref: FMA:293035 xref: SCTID:308770007 xref: TAO:0001599 xref: VHOG:0000299 xref: XAO:0000449 xref: ZFA:0001607 is_a: UBERON:0002539 ! pharyngeal arch property_value: UBPROP:0000001 "The second pharyngeal/branchial arch; arises as a thickening of the pharygeal wall between the first and second branchial clefts; contains the second aortic arch; forms part of the hyoid bone, tongue and facial musculature.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010366", ontology="AAO", source="ISBN:0-02-377110-0"} property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000299", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "in XAO, called branchial arch 2 and df VP4" xsd:string {external_ontology="XAO"} property_value: UBPROP:0000103 "4" xsd:nonNegativeInteger [Term] id: UBERON:0003117 name: pharyngeal arch 6 namespace: uberon alt_id: UBERON:0004349 def: "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." [MP:0006347] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "6th arch" EXACT [EHDAA2:0004075] synonym: "6th pharyngeal arch" RELATED [VHOG:0001205] synonym: "6th visceral arch" RELATED [VHOG:0001205] synonym: "branchial arch 4" RELATED SENSU [AAO:0010368, ZFA:0001609] synonym: "fourth branchial arch" RELATED SENSU [] synonym: "gill arch 4" EXACT [ZFA:0001609] synonym: "sixth branchial arch" EXACT [] synonym: "sixth pharyngeal arch" RELATED [VHOG:0001205] synonym: "sixth visceral arch" RELATED [XAO:0000453] synonym: "visceral arch 6" EXACT [ZFA:0001609] xref: AAO:0010368 xref: EHDAA2:0004075 xref: EMAPA:32766 xref: FMA:293047 xref: SCTID:308772004 xref: TAO:0001601 xref: VHOG:0001205 xref: XAO:0000453 xref: ZFA:0001609 is_a: UBERON:0002539 ! pharyngeal arch property_value: UBPROP:0000001 "The forth in a series of paired bars in the wall of the pharynx, within which are formed the forth aortic arch and the cartilage bar of the visceral skeleton, forms and supports the gills.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010368", ontology="AAO", source="ISBN:0-02-377110-0"} property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001205", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000103 "6" xsd:nonNegativeInteger [Term] id: UBERON:0003118 name: pharyngeal arch artery 1 namespace: uberon alt_id: UBERON:0004371 def: "The vessels formed within the first pair of branchial arches in embryogenesis." [MP:0010355] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "1st aortic arch artery" RELATED [EMAPA:16685] synonym: "1st arch artery" EXACT [EMAPA:16685] synonym: "1st branchial arch artery" RELATED [EMAPA:16685] synonym: "1st pharyngeal arch artery" RELATED [EMAPA:16685] synonym: "AA1" EXACT [ZFA:0005005] synonym: "aortic arch 1" EXACT [ZFA:0005005] synonym: "first aortic arch" EXACT [XAO:0000342] synonym: "first arch artery" RELATED [EMAPA:16685] synonym: "first branchial arch artery" EXACT [] synonym: "mandibular aortic arch" EXACT [ZFA:0005005] xref: AAO:0010415 xref: EHDAA2:0000007 xref: EMAPA:16202 xref: EMAPA:16685 xref: SCTID:308774003 xref: TAO:0005005 xref: VHOG:0000149 xref: XAO:0000342 xref: ZFA:0005005 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: part_of UBERON:0004362 ! pharyngeal arch 1 relationship: contributes_to_morphology_of UBERON:0004362 ! pharyngeal arch 1 relationship: part_of UBERON:0004362 ! pharyngeal arch 1 property_value: UBPROP:0000008 "Disappears early in development in tetrapods" xsd:string property_value: UBPROP:0000012 "ZFA states that The paired aortic arch 1 arteries branch off of the ventral aorta, and empty into the right and left lateral dorsal aortas" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0003121 name: pharyngeal arch artery 4 namespace: uberon alt_id: UBERON:0004350 def: "The vessels formed within the fourth pair of branchial arches in embryogenesis." [MP:0006354] comment: proximal right subclavian subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "4th aortic arch artery" RELATED [EMAPA:17004] synonym: "4th arch artery" EXACT [EHDAA2:0000087] synonym: "4th branchial arch artery" RELATED [EMAPA:17004] synonym: "4th pharyngeal arch artery" RELATED [EMAPA:17004] synonym: "AA4" EXACT [ZFA:0005008] synonym: "aortic arch 4" EXACT [ZFA:0005008] synonym: "fourth aortic arch" EXACT [XAO:0000355] synonym: "fourth branchial arch artery" EXACT [] synonym: "systemic arch" RELATED [ISBN:0073040584, XAO:0000355] xref: AAO:0010420 xref: EHDAA2:0000087 xref: EMAPA:17004 xref: SCTID:308777005 xref: TAO:0005008 xref: Wikipedia:Aortic_arches#Arch_4 xref: XAO:0000355 xref: ZFA:0005008 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: part_of UBERON:0003115 ! pharyngeal arch 4 relationship: part_of UBERON:0003115 ! pharyngeal arch 4 property_value: UBPROP:0000001 "Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005008", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The forth in a series paired arterial connections between the dorsal and ventral aortae, lies within the 4th branchial arch. The paired aortic arch 4 arteries branch directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010420", ontology="AAO", source="ISBN:0-02-377110-0"} property_value: UBPROP:0000001 "The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]." xsd:string {source="Wikipedia:Aortic_arches#Arch_4"} property_value: UBPROP:0000011 "Normally, the left fourth arch becomes the aortic arch, the right fourth arch contributes to the innominate artery[http://emedicine.medscape.com/article/899609-overview] in birds it is the right fourth arch which forms the permanent aorta" xsd:string [Term] id: UBERON:0003123 name: pharyngeal arch artery 6 namespace: uberon alt_id: UBERON:0004351 def: "The vessels formed within the sixth pair of branchial arches in embryogenesis." [MP:0006355] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "6th aortic arch artery" RELATED [EMAPA:17005] synonym: "6th arch artery" EXACT [EMAPA:17005] synonym: "6th branchial arch artery" RELATED [EMAPA:17005] synonym: "6th pharyngeal arch artery" RELATED [EMAPA:17005] synonym: "AA6" EXACT [ZFA:0005016] synonym: "aortic arch 6" EXACT [ZFA:0005016] synonym: "pulmonary arch" RELATED [ISBN:0073040584] synonym: "sixth aortic arch" EXACT [XAO:0000353] synonym: "sixth branchial arch artery" EXACT [] xref: AAO:0010422 xref: EHDAA2:0000102 xref: EMAPA:17005 xref: SCTID:308779008 xref: TAO:0005016 xref: VHOG:0000144 xref: Wikipedia:Aortic_arches#Arch_6 xref: XAO:0000353 xref: ZFA:0005016 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: part_of UBERON:0003117 ! pharyngeal arch 6 relationship: part_of UBERON:0003117 ! pharyngeal arch 6 property_value: UBPROP:0000001 "The fifth and sixth arches, which come on-line at approximately 2.5 dpf, have a common trunk from the ventral aorta and drain to the midline dorsal aorta via an independent route. The fifth and sixth aortic arches supply the trunk and tail with oxigenated blood. Isogai et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005016", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The sixth in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 6 artery is paired and has a common trunk with aortic arch 5 from the ventral aorta, and drains via a separate branch of the lateral dorsal aorta. It forms part of the pulmonary arteries, and in the later embryo, the ductus arteriosis. Aortic arches 5 and 6 together supply the trunk and tail with oxygenated blood.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010422", ontology="AAO", source="ISBN:0-02-377110-0"} property_value: UBPROP:0000001 "The sixth right arch disappears; the sixth left arch gives off the pulmonary arteries and forms the ductus arteriosus; this duct remains pervious during the whole of fetal life, but then closes within the first few days after birth due to increased O2 concentration. Oxygen concentration causes the production of bradykinin which causes the ductus to constrict occluding all flow. Within 1-3 months, the ductus is obliterated and becomes the ligamentum arteriosus. His showed that in the early embryo the right and left arches each gives a branch to the lungs, but that later both pulmonary arteries take origin from the left arch[WP][Wikipedia:Aortic_arches#Arch_6]." xsd:string {source="Wikipedia:Aortic_arches#Arch_6"} property_value: UBPROP:0000011 "the distal left sixth arch becomes the ductus arteriosus, the proximal sixth arches bilaterally contribute to the proximal branch pulmonary arteries" xsd:string {source="http://emedicine.medscape.com/article/899609-overview"} [Term] id: UBERON:0003126 name: trachea namespace: uberon def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [GO:0060438, Wikipedia:Vertebrate_trachea] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: major_organ subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cartilaginous trachea" EXACT [] synonym: "tracheal tubule" RELATED [BTO:0001388] synonym: "vertebrate trachea" EXACT SENSU [] synonym: "windpipe" EXACT [] xref: AAO:0010140 xref: BTO:0001388 xref: CALOHA:TS-1060 xref: EFO:0000935 xref: EHDAA2:0002066 xref: EHDAA:3078 xref: EMAPA:16853 xref: EV:0100040 xref: FMA:7394 xref: GAID:361 xref: MA:0000441 xref: MAT:0000137 xref: MESH:D014132 xref: MIAA:0000137 xref: NCIT:C12428 xref: SCTID:181213009 xref: UMLS:C0040578 {source="ncithesaurus:Trachea"} xref: VHOG:0000371 xref: Wikipedia:Vertebrate_trachea xref: XAO:0000118 is_a: UBERON:0000117 ! respiratory tube relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: located_in UBERON:0002224 ! thoracic cavity relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-female/v1.1/assets/3d-vh-f-trachea.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-male/v1.1/assets/3d-vh-m-trachea.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An elongated tube which carries air to and from the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010140", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000371", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000371", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.409", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "tracheal" xsd:string property_value: UBPROP:0000008 "In birds, the trachea runs from the pharynx to the syrinx, from which the primary bronchi diverge. Swans have an unusually elongated trachea, part of which is coiled beneath the sternum; this may act as a resonator to amplify sound. In some birds, the cartilagenous rings are complete, and may even be ossified. In amphibians, the trachea is normally extremely short, and leads directly into the lungs, without clear primary bronchi. A longer trachea is, however found in some long-necked salamanders, and in caecilians. While there are irregular cartilagenous nodules on the amphibian trachea, these do not form the rings found in amniotes. The only vertebrate to have lungs, but no trachea, is Polypterus, in which the lungs arise directly from the pharynx." xsd:string property_value: UBPROP:0000008 "in mouse 15-18 C-rings, 15-20 in human." xsd:string {source="ISBN:0123813611"} [Term] id: UBERON:0003128 name: cranium namespace: uberon def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cranium_(anatomy)] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bones of cranium" EXACT [FMA:71325] synonym: "calvarium" RELATED [BTO:0001328] synonym: "epicranial plate" RELATED [] synonym: "ossa cranii" EXACT OMO:0003011 [FMA:71325, FMA:TA] synonym: "set of bones of cranium" EXACT [FMA:71325] synonym: "skeletal system of head" RELATED [] synonym: "skull minus mandible" EXACT [] synonym: "upper part of skull" EXACT [] xref: BTO:0001328 xref: EFO:0000831 xref: EHDAA:6029 xref: FMA:71325 xref: MA:0000316 xref: MAT:0000340 xref: MESH:D012886 {https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings", https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000340 xref: SCTID:181889008 xref: VHOG:0000334 xref: Wikipedia:Cranium_(anatomy) is_a: UBERON:0000075 {source="FMA-inferred"} ! subdivision of skeletal system property_value: RO:0002171 UBERON:0003278 property_value: RO:0002175 NCBITaxon:7762 property_value: UBPROP:0000007 "cranial" xsd:string property_value: UBPROP:0000012 "the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium" xsd:string {external_ontology="FMA"} property_value: UBPROP:0000013 "The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton" xsd:string {source="WP"} [Term] id: UBERON:0003129 name: skull namespace: uberon def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." [http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376, PMID:11523816, Wikipedia:Skull] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "cranial skeleton" RELATED [] synonym: "skeletal system of head" RELATED [] xref: BTO:0001295 xref: CALOHA:TS-2344 xref: EHDAA2:0000325 xref: EMAPA:17680 xref: FMA:46565 xref: GAID:82 xref: galen:Skull xref: MESH:D012886 xref: NCIT:C12789 xref: SCTID:110530005 xref: UMLS:C0037303 {source="ncithesaurus:Skull"} xref: Wikipedia:Skull xref: WikipediaCategory:Skull is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: has_part UBERON:0003128 ! cranium relationship: has_part UBERON:0003278 ! skeleton of lower jaw relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0010323 ! cranial skeletal system property_value: UBPROP:0000012 "in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible." xsd:string {external_ontology="FMA"} property_value: UBPROP:0000012 "in many ontologies, the structure called the cranium is inclusive of the mandible/lower jaw skeleton" xsd:string property_value: UBPROP:0000013 "A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates" xsd:string {source="WP"} [Term] id: UBERON:0003133 name: reproductive organ namespace: uberon def: "An organ involved in reproduction." [UBERON:xp] subset: functional_classification subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "genital organ" EXACT [] synonym: "genitalia" RELATED OMO:0003004 [] synonym: "reproductive system organ" EXACT [] synonym: "sex organ" EXACT [] xref: EMAPA:37731 {source="MA:th"} xref: MA:0001752 xref: MESH:D005835 xref: NCIT:C25177 xref: SCTID:128181006 xref: TGMA:0000591 xref: UMLS:C0017420 {source="ncithesaurus:Genitalia"} xref: WBbt:0008422 is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000062 ! organ intersection_of: capable_of_part_of GO:0022414 ! reproductive process relationship: capable_of_part_of GO:0022414 ! reproductive process property_value: UBPROP:0000012 "GO uses genitalia for the singular organ" xsd:string {external_ontology="GO"} [Term] id: UBERON:0003134 name: female reproductive organ namespace: uberon def: "A female organ involved in reproduction." [UBERON:xp] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "female organism reproductive organ" EXACT [OBOL:automatic] synonym: "female organism reproductive structure" EXACT [OBOL:automatic] synonym: "female organism reproductive system organ" EXACT [OBOL:automatic] synonym: "female organism sex organ" EXACT [OBOL:automatic] synonym: "female reproductive gland/organ" EXACT [MA:0000544] synonym: "female reproductive system organ" EXACT [] synonym: "female sex organ" EXACT [] synonym: "reproductive organ of female organism" EXACT [OBOL:automatic] synonym: "reproductive structure of female organism" EXACT [OBOL:automatic] synonym: "reproductive system organ of female organism" EXACT [OBOL:automatic] synonym: "sex organ of female organism" EXACT [OBOL:automatic] xref: EMAPA:28540 xref: MA:0000544 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0000474 ! female reproductive system [Term] id: UBERON:0003218 name: ovary septum namespace: uberon def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." [GO:0080126] subset: human_subset subset: mouse_subset is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary [Term] id: UBERON:0003235 name: epithelium of upper jaw namespace: uberon def: "An epithelium that is part of a upper jaw [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "epithelial tissue of upper jaw" EXACT [OBOL:automatic] synonym: "epithelium of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "palatoquadrate arch epithelial tissue" EXACT [OBOL:automatic] synonym: "palatoquadrate arch epithelium" EXACT [OBOL:automatic] synonym: "upper jaw epithelial tissue" EXACT [OBOL:automatic] synonym: "upper jaw epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0002119 xref: EHDAA:8027 xref: EMAPA:18971 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: part_of UBERON:0001709 ! upper jaw region [Term] id: UBERON:0003236 name: epithelium of lower jaw namespace: uberon def: "An epithelium that is part of a lower jaw [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of lower jaw" EXACT [OBOL:automatic] synonym: "epithelial tissue of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "epithelium of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "lower jaw epithelial tissue" EXACT [OBOL:automatic] synonym: "lower jaw epithelium" EXACT [OBOL:automatic] synonym: "ventral mandibular arch epithelial tissue" EXACT [OBOL:automatic] synonym: "ventral mandibular arch epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0001019 xref: EHDAA:7999 xref: EMAPA:35516 xref: VHOG:0000802 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001710 ! lower jaw region relationship: part_of UBERON:0001710 ! lower jaw region [Term] id: UBERON:0003257 name: yolk sac endoderm namespace: uberon def: "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." [UBERON:cjm] subset: human_subset subset: mouse_subset xref: EHDAA2:0002215 xref: EHDAA:166 xref: EMAPA:16086 xref: VHOG:0000626 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: bounding_layer_of UBERON:0001040 ! yolk sac intersection_of: develops_from UBERON:0000925 ! endoderm relationship: bounding_layer_of UBERON:0001040 ! yolk sac relationship: part_of UBERON:0001040 ! yolk sac [Term] id: UBERON:0003258 name: endoderm of foregut namespace: uberon def: "An endoderm that is part of a foregut [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "foregut endoderm" EXACT [OBOL:automatic] xref: EHDAA2:0004568 xref: EHDAA:524 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001041 ! foregut property_value: editor_note "TODO - check" xsd:string [Term] id: UBERON:0003259 name: endoderm of midgut namespace: uberon def: "An endoderm that is part of a midgut [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "midgut endoderm" EXACT [OBOL:automatic] xref: EHDAA:987 xref: EMAPA:16257 xref: RETIRED_EHDAA2:0001194 xref: VHOG:0001080 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003352 ! epithelium of midgut is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001045 ! midgut property_value: editor_note "TODO - check" xsd:string [Term] id: UBERON:0003260 name: endoderm of hindgut namespace: uberon def: "An endoderm that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "hindgut endoderm" EXACT [OBOL:automatic] xref: EHDAA:979 xref: RETIRED_EHDAA2:0000781 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003353 ! epithelium of hindgut is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001046 ! hindgut property_value: editor_note "TODO - check" xsd:string [Term] id: UBERON:0003269 name: skeletal muscle tissue of eye namespace: uberon def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "eye skeletal muscle" EXACT [OBOL:automatic] synonym: "eye skeletal muscle group" RELATED [EHDAA2:0000486] synonym: "eye skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of eye" EXACT [OBOL:automatic] xref: EHDAA2:0000486 xref: EHDAA:2923 xref: EMAPA:17844 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003277 name: skeleton of upper jaw namespace: uberon def: "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "upper jaw" BROAD [MA:0001908] synonym: "upper jaw skeleton" EXACT [] xref: AAO:0000622 xref: EHDAA2:0002128 xref: EHDAA:8041 xref: EMAPA:17927 xref: FMA:54397 xref: MA:0001908 xref: VHOG:0000429 xref: XAO:0003087 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0001709 ! upper jaw region relationship: part_of UBERON:0001708 ! jaw skeleton relationship: part_of UBERON:0001709 ! upper jaw region relationship: skeleton_of UBERON:0001709 ! upper jaw region property_value: UBPROP:0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000429", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "EMAPA/MA placement unclear. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" xsd:string {external_ontology="EMAPA"} [Term] id: UBERON:0003278 name: skeleton of lower jaw namespace: uberon def: "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "lower jaw" BROAD [MA:0001906, ZFA:0001273] synonym: "lower jaw skeleton" EXACT [AAO:0000274] synonym: "mandible" BROAD [ZFA:0001273] synonym: "mandibles" RELATED OMO:0003004 [TAO:0001273] synonym: "mandibular series" RELATED [ZFA:0001273] xref: AAO:0000274 xref: EHDAA2:0004606 xref: EHDAA:8005 xref: EMAPA:17910 xref: FMA:54398 xref: MA:0001906 xref: TAO:0001273 xref: VHOG:0000428 xref: XAO:0003084 xref: ZFA:0001273 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0001710 ! lower jaw region relationship: overlaps UBERON:0008895 {source="VHOG-modified"} ! splanchnocranium relationship: part_of UBERON:0001708 ! jaw skeleton relationship: part_of UBERON:0001710 {source="EHDAA2"} ! lower jaw region relationship: skeleton_of UBERON:0001710 ! lower jaw region property_value: UBPROP:0000001 "The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001273", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000428", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0003279 name: endothelium of trachea namespace: uberon def: "An endothelium that is part of a trachea." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "endothelium of windpipe" EXACT [OBOL:automatic] synonym: "trachea endothelium" EXACT [OBOL:automatic] synonym: "windpipe endothelium" EXACT [OBOL:automatic] xref: EHDAA:3082 xref: RETIRED_EHDAA2:0002068 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001901 ! epithelium of trachea is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003294 name: gland of foregut namespace: uberon def: "A gland that is part of a foregut [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "foregut gland" EXACT [OBOL:automatic] xref: EHDAA2:0000567 xref: EHDAA:950 xref: EMAPA:16557 xref: VHOG:0000650 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001041 ! foregut relationship: part_of UBERON:0001041 ! foregut [Term] id: UBERON:0003295 name: pharyngeal gland namespace: uberon def: "Racemose mucous glands beneath the mucous membrane of the pharynx." [http://www.biology-online.org/dictionary/] subset: human_subset subset: mouse_subset subset: organ_slim synonym: "glandulae pharyngeae" RELATED [BTO:0004849] synonym: "pharynx gland" EXACT [EHDAA2:0001461] xref: BTO:0004849 xref: EHDAA2:0001461 xref: EHDAA:2967 xref: FMA:55075 is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 {source="BTO"} ! chordate pharynx [Term] id: UBERON:0003297 name: gland of integumental system namespace: uberon def: "A gland that is part of a integumental system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "integumental gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "integumental system gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "integumentary gland" EXACT [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000837 xref: EMAPA:17758 xref: MA:0000144 xref: VHOG:0000654 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0002416 ! integumental system relationship: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0003304 name: mesoderm blood island namespace: uberon alt_id: UBERON:0003305 def: "A blood island that is part of a mesoderm." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mesenchyme blood island" RELATED [OBOL:automatic] synonym: "mesoderm blood islands" EXACT OMO:0003004 [EHDAA2:0003241] xref: EHDAA2:0003241 xref: EHDAA:170 is_a: UBERON:0003061 ! blood island is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0003061 ! blood island intersection_of: part_of UBERON:0000926 ! mesoderm relationship: part_of UBERON:0000926 ! mesoderm relationship: part_of UBERON:0007798 {source="EHDAA2"} ! vascular system property_value: UBPROP:0000012 "in EHDAA2, gives rise to blood and dorsal aorta" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0003314 name: eye mesenchyme namespace: uberon def: "Mesenchyme that is part of a developing camera-type eye." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mesenchyme of eye" EXACT [OBOL:automatic] xref: EHDAA2:0000485 xref: EHDAA:2910 xref: EMAPA:16673 xref: VHOG:0001084 is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0009920 {source="EHDAA2"} ! optic neural crest relationship: part_of UBERON:0000019 ! camera-type eye property_value: editor_note "TODO - change mesenchyme relationships to precursor_of" xsd:string [Term] id: UBERON:0003315 name: mesenchyme of ovary namespace: uberon def: "Mesenchyme that is part of a developing ovary [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "female reproductive system gonad mesenchyme" EXACT [OBOL:automatic] synonym: "female reproductive system gonada mesenchyme" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system mesenchyme" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of female reproductive system gonad" EXACT [OBOL:automatic] synonym: "mesenchyme of female reproductive system gonada" EXACT [OBOL:automatic] synonym: "mesenchyme of gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "mesenchyme of gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "ovary mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001362 xref: EHDAA:8128 xref: VHOG:0001441 is_a: UBERON:0003855 ! gonad mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003316 name: mesenchyme of yolk sac namespace: uberon alt_id: UBERON:0003264 def: "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." [UBERON:cjm] subset: human_subset subset: mouse_subset synonym: "yolk sac mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0002216 xref: EHDAA:168 xref: EHDAA:205 xref: EMAPA:16087 xref: EMAPA:16267 xref: VHOG:0000503 xref: VHOG:0000617 is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001040 ! yolk sac relationship: part_of UBERON:0001040 ! yolk sac [Term] id: UBERON:0003323 name: mesenchyme of upper jaw namespace: uberon def: "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mesenchyme of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "palatoquadrate arch mesenchyme" EXACT [OBOL:automatic] synonym: "upper jaw mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0002124 xref: EHDAA:8031 xref: EMAPA:17929 xref: VHOG:0001099 is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: develops_from UBERON:0009526 {source="EHDAA2"} ! maxillary process mesenchyme relationship: part_of UBERON:0001709 ! upper jaw region [Term] id: UBERON:0003324 name: mesenchyme of lower jaw namespace: uberon def: "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "lower jaw mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "ventral mandibular arch mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001024 xref: EHDAA:8003 xref: EMAPA:17916 xref: VHOG:0001069 is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001710 ! lower jaw region relationship: develops_from UBERON:0006905 {source="EHDAA2"} ! mandibular process mesenchyme relationship: part_of UBERON:0001710 ! lower jaw region [Term] id: UBERON:0003329 name: submucosa of anal canal namespace: uberon def: "A submucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "anal canal submucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically submucosa" EXACT [OBOL:automatic] synonym: "anal region submucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal submucosa" EXACT [OBOL:automatic] synonym: "submucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "submucosa of anal region" EXACT [OBOL:automatic] synonym: "submucosa of anatomical anal canal" EXACT [OBOL:automatic] xref: EMAPA:27217 xref: EMAPA:27227 xref: EMAPA:27535 xref: FMA:85399 xref: SCTID:7892006 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003330 name: submucosa of rectum namespace: uberon def: "The submucous layer of the wall of the rectum." [BTO:0002114] subset: human_subset subset: mouse_subset synonym: "rectal submucosa" EXACT [FMA:15034] synonym: "rectum submucosa" EXACT [OBOL:automatic] synonym: "tela submucosa recti" EXACT OMO:0003011 [BTO:0002114] xref: BTO:0002114 xref: EMAPA:27083 xref: FMA:15034 xref: SCTID:71683001 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003331 name: submucosa of colon namespace: uberon def: "A submucosa that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "colon submucosa" EXACT [OBOL:automatic] synonym: "colonic submucosa" EXACT [FMA:14985] synonym: "large bowel submucosa" EXACT [OBOL:automatic] synonym: "submucosa of large bowel" EXACT [OBOL:automatic] xref: EMAPA:27379 xref: FMA:14985 xref: MA:0003200 xref: SCTID:61647009 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003332 name: submucosa of duodenum namespace: uberon def: "A submucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "doudenal submucosa" EXACT [FMA:14943] synonym: "duodenal submucosa" EXACT [FMA:14943] synonym: "duodenum submucosa" EXACT [OBOL:automatic] xref: EMAPA:27027 xref: EMAPA:27097 xref: EMAPA:27239 xref: FMA:14943 xref: MA:0003213 xref: SCTID:76519004 is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003334 name: serosa of rectum namespace: uberon def: "A serous membrane that is part of a rectum [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "rectal serosa" EXACT [FMA:15039] synonym: "rectum serosa" EXACT [OBOL:automatic] synonym: "rectum serous membrane" EXACT [OBOL:automatic] synonym: "serous membrane of rectum" EXACT [OBOL:automatic] synonym: "visceral peritoneum of rectum" EXACT [FMA:15039] xref: EMAPA:27087 xref: FMA:15039 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003335 name: serosa of colon namespace: uberon def: "A serous membrane that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "colon serosa" EXACT [OBOL:automatic] synonym: "colon serous membrane" EXACT [OBOL:automatic] synonym: "colonic serosa" EXACT [FMA:14990] synonym: "large bowel serosa" EXACT [OBOL:automatic] synonym: "large bowel serous membrane" EXACT [OBOL:automatic] synonym: "serosa of large bowel" EXACT [OBOL:automatic] synonym: "serous membrane of colon" EXACT [OBOL:automatic] synonym: "serous membrane of large bowel" EXACT [OBOL:automatic] synonym: "visceral peritoneum of colon" EXACT [FMA:14990] xref: EMAPA:27387 xref: FMA:14990 xref: MA:0003199 xref: SCTID:90132000 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003336 name: serosa of duodenum namespace: uberon def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "doudenal serosa" EXACT [FMA:14948] synonym: "duodenal serosa" EXACT [FMA:14948] synonym: "duodenum serosa" EXACT [OBOL:automatic] synonym: "duodenum serous membrane" EXACT [OBOL:automatic] synonym: "serous membrane of duodenum" EXACT [OBOL:automatic] synonym: "visceral peritoneum of duodenum" EXACT [FMA:14948] xref: EMAPA:27247 xref: FMA:14948 xref: MA:0003212 xref: SCTID:1236009 is_a: UBERON:0001206 ! serosa of small intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "1st part serosa, 2nd - 4th adventitia" xsd:string [Term] id: UBERON:0003338 name: ganglion of peripheral nervous system namespace: uberon def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." [BIRNLEX:2548] subset: cumbo subset: human_subset subset: mouse_subset synonym: "peripheral nervous system ganglion" EXACT [OBOL:automatic] xref: BIRNLEX:2548 xref: BTO:0001123 xref: EMAPA:32814 xref: MA:0001161 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0000010 ! peripheral nervous system relationship: part_of UBERON:0000010 ! peripheral nervous system property_value: UBPROP:0000012 "we follow MA in including separate classes for ganglion and peripheral nervous system, even though for vertebrates gangia are always in the PNS" xsd:string {external_ontology="MA"} [Term] id: UBERON:0003339 name: ganglion of central nervous system namespace: uberon def: "A ganglion that is part of a central nervous system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "central nervous system ganglion" EXACT [OBOL:automatic] synonym: "ganglion of neuraxis" EXACT [OBOL:automatic] synonym: "neuraxis ganglion" EXACT [OBOL:automatic] xref: EHDAA2:0000227 xref: EMAPA:16658 xref: FMA:83843 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system property_value: UBPROP:0000012 "this has no subclasses in FMA. In EHDAA2 and EMAPA it has only the cranial ganglia" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0003342 name: mucosa of anal canal namespace: uberon def: "A mucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "anal canal mucosa" EXACT [OBOL:automatic] synonym: "anal canal mucosa of organ" EXACT [OBOL:automatic] synonym: "anal canal mucous membrane" EXACT [OBOL:automatic] synonym: "anal canal organ mucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucosa of organ" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucous membrane" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically organ mucosa" EXACT [OBOL:automatic] synonym: "anal mucosa" EXACT [FMA:74654] synonym: "anal mucous membrane" EXACT [FMA:74654] synonym: "anal region mucosa" EXACT [OBOL:automatic] synonym: "anal region mucosa of organ" EXACT [OBOL:automatic] synonym: "anal region mucous membrane" EXACT [OBOL:automatic] synonym: "anal region organ mucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucosa of organ" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucous membrane" EXACT [OBOL:automatic] synonym: "anatomical anal canal organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucosa of anal region" EXACT [OBOL:automatic] synonym: "mucosa of anatomical anal canal" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal canal" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal region" EXACT [OBOL:automatic] synonym: "mucosa of organ of anatomical anal canal" EXACT [OBOL:automatic] synonym: "mucous membrane of anal canal" EXACT [OBOL:automatic] synonym: "mucous membrane of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucous membrane of anal region" EXACT [OBOL:automatic] synonym: "mucous membrane of anatomical anal canal" EXACT [OBOL:automatic] synonym: "organ mucosa of anal canal" EXACT [OBOL:automatic] synonym: "organ mucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "organ mucosa of anal region" EXACT [OBOL:automatic] synonym: "organ mucosa of anatomical anal canal" EXACT [OBOL:automatic] xref: EMAPA:27531 xref: FMA:74654 xref: NCIT:C60784 xref: SCTID:362170004 xref: UMLS:C0227414 {source="ncithesaurus:Anal_Mucosa"} is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003343 name: mucosa of oral region namespace: uberon def: "A mucosa that is part of a oral opening [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mucosa of oral opening" EXACT [OBOL:automatic] synonym: "mucosa of oral part of face" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral opening" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral part of face" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral region" EXACT [OBOL:automatic] synonym: "mucosa of organ of subdivision of mouth" EXACT [OBOL:automatic] synonym: "mucosa of subdivision of mouth" EXACT [OBOL:automatic] synonym: "mucous membrane of oral opening" EXACT [OBOL:automatic] synonym: "mucous membrane of oral part of face" EXACT [OBOL:automatic] synonym: "mucous membrane of oral region" EXACT [OBOL:automatic] synonym: "mucous membrane of subdivision of mouth" EXACT [OBOL:automatic] synonym: "oral opening mucosa" EXACT [OBOL:automatic] synonym: "oral opening mucosa of organ" EXACT [OBOL:automatic] synonym: "oral opening mucous membrane" EXACT [OBOL:automatic] synonym: "oral opening organ mucosa" EXACT [OBOL:automatic] synonym: "oral part of face mucosa" EXACT [OBOL:automatic] synonym: "oral part of face mucosa of organ" EXACT [OBOL:automatic] synonym: "oral part of face mucous membrane" EXACT [OBOL:automatic] synonym: "oral part of face organ mucosa" EXACT [OBOL:automatic] synonym: "oral region mucosa" EXACT [OBOL:automatic] synonym: "oral region mucosa of organ" EXACT [OBOL:automatic] synonym: "oral region mucous membrane" EXACT [OBOL:automatic] synonym: "oral region organ mucosa" EXACT [OBOL:automatic] synonym: "organ mucosa of oral opening" EXACT [OBOL:automatic] synonym: "organ mucosa of oral part of face" EXACT [OBOL:automatic] synonym: "organ mucosa of oral region" EXACT [OBOL:automatic] synonym: "organ mucosa of subdivision of mouth" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucosa" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucosa of organ" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucous membrane" EXACT [OBOL:automatic] synonym: "subdivision of mouth organ mucosa" EXACT [OBOL:automatic] xref: SCTID:362083000 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000166 ! oral opening relationship: part_of UBERON:0000166 ! oral opening [Term] id: UBERON:0003346 name: mucosa of rectum namespace: uberon def: "A mucosa that is part of a rectum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mucosa of organ of rectum" EXACT [OBOL:automatic] synonym: "mucous membrane of rectum" EXACT [OBOL:automatic] synonym: "organ mucosa of rectum" EXACT [OBOL:automatic] synonym: "rectal mucosa" EXACT [FMA:15033] synonym: "rectal mucous membrane" EXACT [FMA:15033] synonym: "rectum mucosa" EXACT [OBOL:automatic] synonym: "rectum mucosa of organ" EXACT [OBOL:automatic] synonym: "rectum mucous membrane" EXACT [OBOL:automatic] synonym: "rectum organ mucosa" EXACT [OBOL:automatic] xref: CALOHA:TS-2107 xref: EMAPA:27081 xref: FMA:15033 xref: MA:0003218 xref: SCTID:362167003 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003350 name: epithelium of mucosa namespace: uberon def: "A layer of epithelial cells on the surface of the mucosa." [BTO:0003752] comment: lies on top of lamina propria subset: human_subset subset: mouse_subset synonym: "lamina epithelialis mucosa" RELATED [BTO:0003752] synonym: "lamina epithelialis mucosae" RELATED [BTO:0003752] xref: BTO:0003752 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000344 ! mucosa relationship: part_of UBERON:0000344 ! mucosa [Term] id: UBERON:0003351 name: pharyngeal epithelium namespace: uberon def: "An epithelium that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "epithelial tissue of pharynx" EXACT [OBOL:automatic] synonym: "epithelium of pharynx" EXACT [OBOL:automatic] synonym: "pharynx epithelial tissue" EXACT [OBOL:automatic] synonym: "pharynx epithelium" EXACT [OBOL:automatic] xref: BSA:0000112 xref: BTO:0005240 xref: EMAPA:16708 xref: MA:0002725 xref: RETIRED_EHDAA2:0001460 xref: TAO:0001174 xref: XAO:0003202 xref: ZFA:0001174 is_a: UBERON:0000490 {gci_relation="part_of", gci_filler="NCBITaxon:7955", source="ZFA"} ! unilaminar epithelium is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: develops_from UBERON:0007690 {source="ZFA"} ! early pharyngeal endoderm relationship: part_of UBERON:0001042 {source="ZFA"} ! chordate pharynx property_value: UBPROP:0000001 "Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001174", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0003352 name: epithelium of midgut namespace: uberon def: "An epithelium that is part of a midgut." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of midgut" EXACT [OBOL:automatic] synonym: "midgut epithelial tissue" EXACT [OBOL:automatic] synonym: "midgut epithelium" EXACT [BTO:0005053, OBOL:automatic] xref: BTO:0005053 xref: EHDAA2:0001195 xref: EMAPA:16569 xref: MA:0003205 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001045 ! midgut relationship: part_of UBERON:0001045 {source="BTO"} ! midgut [Term] id: UBERON:0003353 name: epithelium of hindgut namespace: uberon def: "An epithelium that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of hindgut" EXACT [OBOL:automatic] synonym: "hindgut epithelial tissue" EXACT [OBOL:automatic] synonym: "hindgut epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0000782 xref: EMAPA:16717 xref: MA:0003206 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut [Term] id: UBERON:0003354 name: epithelium of rectum namespace: uberon def: "An epithelium that is part of a rectum [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of rectum" EXACT [OBOL:automatic] synonym: "rectal epithelium" EXACT [FMA:17510] synonym: "rectum epithelial tissue" EXACT [OBOL:automatic] synonym: "rectum epithelium" EXACT [OBOL:automatic] xref: CALOHA:TS-2066 xref: EHDAA2:0001594 xref: EMAPA:17898 xref: FMA:17510 xref: MA:0003219 xref: VHOG:0001037 is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: UBERON:0003364 name: epithelium of right lung namespace: uberon def: "An epithelium that is part of a right lung [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of right lung" EXACT [OBOL:automatic] synonym: "right lung epithelial tissue" EXACT [OBOL:automatic] synonym: "right lung epithelium" EXACT [OBOL:automatic] xref: EMAPA:17663 xref: MA:0003132 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002167 ! right lung relationship: part_of UBERON:0002167 ! right lung [Term] id: UBERON:0003365 name: epithelium of left lung namespace: uberon def: "An epithelium that is part of a left lung [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "epithelial tissue of left lung" EXACT [OBOL:automatic] synonym: "left lung epithelial tissue" EXACT [OBOL:automatic] synonym: "left lung epithelium" EXACT [OBOL:automatic] xref: EMAPA:17655 xref: MA:0003131 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002168 ! left lung relationship: part_of UBERON:0002168 ! left lung [Term] id: UBERON:0003372 name: pectoral appendage bud ectoderm namespace: uberon alt_id: UBERON:0005231 alt_id: UBERON:0005663 def: "An unilaminar epithelium that surrounds a pectoral appendage bud." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arm ectoderm" RELATED [OBOL:automatic] synonym: "forelimb bud ectoderm" NARROW SENSU [EMAPA:16407] synonym: "forelimb ectoderm" NARROW SENSU [VHOG:0001047] synonym: "pectoral fin bud ectoderm" NARROW SENSU [] synonym: "upper limb bud ectoderm" NARROW SENSU [EHDAA2:0002134] synonym: "wing ectoderm" NARROW SENSU [Geisha:syn, NCBITaxon:8782] xref: EHDAA2:0002134 xref: EMAPA:16407 xref: VHOG:0001047 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: bounding_layer_of UBERON:0005419 ! pectoral appendage bud relationship: bounding_layer_of UBERON:0005419 ! pectoral appendage bud relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm relationship: part_of UBERON:0005419 ! pectoral appendage bud [Term] id: UBERON:0003379 name: cardiac muscle of right atrium namespace: uberon def: "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac muscle of cardiac right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of heart right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of heart right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of right atrium of heart" EXACT [OBOL:automatic] synonym: "myocardium of right atrium" EXACT [] synonym: "right atrium heart muscle" EXACT [EHDAA2:0004155] synonym: "right atrium myocardium" EXACT [VHOG:0001227] synonym: "textus muscularis of myocardium of right atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of right atrium of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of right cardiac atrium" EXACT [OBOL:automatic] xref: EHDAA2:0004155 xref: EMAPA:17326 xref: FMA:7282 xref: SCTID:362018002 xref: VHOG:0001227 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002078 ! right cardiac atrium relationship: part_of UBERON:0002078 ! right cardiac atrium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003380 name: cardiac muscle of left atrium namespace: uberon def: "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac left atrium cardiac muscle" EXACT [OBOL:automatic] synonym: "cardiac left atrium cardiac muscle tissue" EXACT [OBOL:automatic] synonym: "cardiac muscle of cardiac left atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of heart left atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of left atrium of heart" EXACT [OBOL:automatic] synonym: "left atrium heart muscle" EXACT [EHDAA2:0004154] synonym: "left atrium myocardium" EXACT [VHOG:0001225] synonym: "myocardium of left atrium" EXACT [] synonym: "textus muscularis of myocardium of cardiac left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of heart left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left atrium of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left cardiac atrium" EXACT [OBOL:automatic] xref: EHDAA2:0004154 xref: EMAPA:17320 xref: FMA:7285 xref: SCTID:189936008 xref: VHOG:0001225 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002079 ! left cardiac atrium relationship: part_of UBERON:0002079 ! left cardiac atrium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003381 name: cardiac muscle of right ventricle namespace: uberon def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cardiac muscle tissue of right ventricle" EXACT [FMA:83452] synonym: "right ventricle cardiac muscle" RELATED [VHOG:0001236] synonym: "right ventricular cardiac muscle tissue" EXACT [GO:0003221] xref: EMAPA:17342 xref: FMA:83452 xref: VHOG:0001236 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0003382 name: cardiac muscle of left ventricle namespace: uberon def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cardiac muscle tissue of left ventricle" EXACT [FMA:83453] synonym: "left ventricle cardiac muscle" RELATED [VHOG:0001234] synonym: "left ventricular cardiac muscle tissue" EXACT [GO:0003220] xref: EMAPA:17339 xref: FMA:83453 xref: VHOG:0001234 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0003383 name: cardiac muscle tissue of interventricular septum namespace: uberon def: "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac muscle of interventricular septum" EXACT [] synonym: "cardiac muscle tissue of interventricular septum" EXACT [FMA:84084] synonym: "interventricular septum cardiac muscle" EXACT [VHOG:0000999] synonym: "interventricular septum heart muscle" EXACT [EHDAA2:0004158] synonym: "interventricular septum muscle" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "interventricular septum myocardium" EXACT [VHOG:0000999] xref: EHDAA2:0004158 xref: EMAPA:17335 xref: FMA:84084 xref: VHOG:0000999 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum is_a: UBERON:0004667 ! interventricular septum muscular part intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002094 ! interventricular septum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003384 name: skeletal muscle tissue of pharynx namespace: uberon def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "pharynx skeletal muscle" EXACT [OBOL:automatic] synonym: "pharynx skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of pharynx" EXACT [OBOL:automatic] xref: EMAPA:18963 is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx [Term] id: UBERON:0003386 name: smooth muscle of eye namespace: uberon def: "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." [MGI:cwg, MP:0005247] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "ocular smooth muscle" EXACT [MA:0001268] xref: EMAPA:18807 xref: MA:0001268 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: contributes_to_morphology_of UBERON:0001015 ! musculature relationship: part_of UBERON:0000019 ! camera-type eye property_value: editor_note "Not clear if we need this and intra-ocular muscle. See issue #331. MA includes ciliary and iris smooth muscle" xsd:string [Term] id: UBERON:0003387 name: smooth muscle of trachea namespace: uberon alt_id: UBERON:0004244 def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "trachea smooth muscle" EXACT [MA:0001863] synonym: "tracheal smooth muscle" EXACT [BTO:0001391] xref: BTO:0001391 xref: EMAPA:19192 xref: FMA:262010 xref: MA:0001863 xref: NCIT:C49306 xref: UMLS:C1710458 {source="ncithesaurus:Trachea_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: contributes_to_morphology_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003388 name: mesothelium of pericardial cavity namespace: uberon def: "A mesothelium that is part of a pericardium [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavity of pericardial sac meso-epithelium" EXACT [OBOL:automatic] synonym: "cavity of pericardial sac mesothelium" EXACT [OBOL:automatic] synonym: "meso-epithelium of cavity of pericardial sac" EXACT [OBOL:automatic] synonym: "meso-epithelium of pericardial cavity" EXACT [OBOL:automatic] synonym: "mesothelium of cavity of pericardial sac" EXACT [OBOL:automatic] synonym: "pericardial cavity meso-epithelium" EXACT [OBOL:automatic] synonym: "pericardial cavity mesothelium" EXACT [OBOL:automatic] xref: RETIRED_EHDAA2:0001436 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: part_of UBERON:0002407 ! pericardium relationship: part_of UBERON:0002407 ! pericardium [Term] id: UBERON:0003389 name: mesothelium of diaphragm namespace: uberon def: "A mesothelium that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "diaphragm meso-epithelium" EXACT [OBOL:automatic] synonym: "diaphragm mesothelium" EXACT [OBOL:automatic] synonym: "meso-epithelium of diaphragm" EXACT [OBOL:automatic] synonym: "meso-epithelium of thoracic diaphragm" EXACT [OBOL:automatic] synonym: "mesothelium of thoracic diaphragm" EXACT [OBOL:automatic] synonym: "thoracic diaphragm meso-epithelium" EXACT [OBOL:automatic] synonym: "thoracic diaphragm mesothelium" EXACT [OBOL:automatic] xref: EMAPA:18429 is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: part_of UBERON:0001103 ! diaphragm relationship: part_of UBERON:0001103 ! diaphragm [Term] id: UBERON:0003390 name: mesothelium of pleural cavity namespace: uberon def: "A mesothelium that is part of a pleural cavity [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "meso-epithelium of pleural cavity" EXACT [OBOL:automatic] synonym: "mesothelium of pleura" EXACT [FMA:18148] synonym: "pleura" RELATED [EMAPA:16775] synonym: "pleural cavity meso-epithelium" EXACT [OBOL:automatic] synonym: "pleural cavity mesothelium" EXACT [OBOL:automatic] synonym: "pleural mesothelium" EXACT [EMAPA:16775] xref: BTO:0003155 xref: EHDAA2:0001476 xref: EMAPA:16775 xref: FMA:18148 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: located_in UBERON:0002402 ! pleural cavity relationship: located_in UBERON:0002402 ! pleural cavity [Term] id: UBERON:0003406 name: cartilage of respiratory system namespace: uberon def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius cartilage" EXACT [OBOL:automatic] synonym: "cartilage of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "respiratory system cartilage" EXACT [OBOL:automatic] xref: EMAPA:18694 xref: MA:0001818 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003408 name: gland of digestive tract namespace: uberon def: "A gland that is part of a digestive tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "digestive tract gland" EXACT [OBOL:automatic] synonym: "gland of digestive tract" EXACT [OBOL:automatic] synonym: "gland of lower gastrointestinal tract" EXACT [OBOL:automatic] synonym: "gut gland" EXACT [MA:0003202] synonym: "lower gastrointestinal tract gland" EXACT [OBOL:automatic] xref: EMAPA:18815 xref: MA:0003202 is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0003413 name: pectoral appendage bud mesenchyme namespace: uberon alt_id: UBERON:0005703 def: "Mesenchyme that is part of a pectoral appendage bud." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "arm mesenchyme" NARROW [OBOL:automatic] synonym: "forelimb bud mesenchyme" NARROW SENSU [EMAPA:16408] synonym: "mesoderm pectoral fin bud" NARROW SENSU [ZFA:0000789] synonym: "pectoral fin bud mesenchyme" NARROW SENSU [] synonym: "upper limb bud mesenchyme" NARROW [EHDAA2:0002135] synonym: "wing mesenchyme" NARROW [OBOL:automatic] xref: EHDAA2:0002135 xref: EHDAA:1703 xref: EMAPA:16408 xref: TAO:0000789 xref: ZFA:0000789 is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0005419 ! pectoral appendage bud relationship: develops_from UBERON:0005729 ! pectoral appendage field relationship: part_of UBERON:0005419 ! pectoral appendage bud property_value: UBPROP:0000001 "Mesoderm that is part of the pectoral fin bud.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000789", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0003426 name: dermis adipose tissue namespace: uberon def: "An adipose tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "adipose tissue of dermis" EXACT [OBOL:automatic] synonym: "dermis fat tissue" EXACT [OBOL:automatic] synonym: "dermis fatty tissue" EXACT [OBOL:automatic] synonym: "fat tissue of dermis" EXACT [OBOL:automatic] synonym: "fatty tissue of dermis" EXACT [OBOL:automatic] xref: MA:0000798 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003585 ! dermis connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0002067 ! dermis [Term] id: UBERON:0003429 name: abdomen nerve namespace: uberon def: "A nerve that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "nerve of abdomen" EXACT [OBOL:automatic] xref: MA:0000521 is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003430 name: neck nerve namespace: uberon def: "A nerve that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "neck (volume) nerve" EXACT [OBOL:automatic] synonym: "nerve of neck" EXACT [OBOL:automatic] synonym: "nerve of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37263 {source="MA:th"} xref: MA:0000588 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003438 name: iris nerve namespace: uberon def: "Any nerve that innervates the iris." [UBERON:cjm] subset: human_subset subset: mouse_subset synonym: "ciliary nerve" NARROW [] synonym: "nerve of iris" EXACT [OBOL:automatic] xref: EMAPA:35449 xref: MA:0001291 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0001769 ! iris relationship: innervates UBERON:0001769 ! iris property_value: editor_note "added for consistency with mouse ontologies. The term 'ciliary nerve' is usually used to denote either of the two nerves (with different origins) that innervate the iris, as well as ciliary muscles and cornea" xsd:string [Term] id: UBERON:0003439 name: nerve of trunk region namespace: uberon def: "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset subset: non_informative synonym: "nerve of torso" EXACT [OBOL:automatic] synonym: "nerve of trunk" EXACT [OBOL:automatic] synonym: "torso nerve" EXACT [OBOL:automatic] synonym: "trunk nerve" RELATED [MA:0000515] xref: EMAPA:37264 {source="MA:th"} xref: MA:0000515 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003443 name: thoracic cavity nerve namespace: uberon def: "A nerve that is located in a thoracic cavity [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavity of chest nerve" EXACT [OBOL:automatic] synonym: "cavity of thorax nerve" EXACT [OBOL:automatic] synonym: "chest cavity nerve" EXACT [OBOL:automatic] synonym: "nerve of cavity of chest" EXACT [OBOL:automatic] synonym: "nerve of cavity of thorax" EXACT [OBOL:automatic] synonym: "nerve of chest cavity" EXACT [OBOL:automatic] synonym: "nerve of pectoral cavity" EXACT [OBOL:automatic] synonym: "nerve of thoracic cavity" EXACT [OBOL:automatic] synonym: "pectoral cavity nerve" EXACT [OBOL:automatic] xref: EMAPA:37267 {source="MA:th"} xref: MA:0000556 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: located_in UBERON:0002224 ! thoracic cavity relationship: located_in UBERON:0002224 ! thoracic cavity property_value: editor_note "consider merging with thoracic nerve. In MA the only subclass is the phrenic nerve, which arises from a cervical nerve" xsd:string [Term] id: UBERON:0003452 name: trabecula carnea cardiac muscle tissue namespace: uberon def: "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cardiac muscle muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart muscle muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart muscle textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart myocardium muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart myocardium textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle of heart muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle of heart textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of heart muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of heart myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of muscle of heart of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "myocardium muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "myocardium textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of heart muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of heart myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of muscle of heart of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea heart muscle muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea heart muscle textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea heart myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea heart myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle of heart muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle of heart textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of heart muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of heart myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of muscle of heart" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of heart muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of heart myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of muscle of heart" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of myocardium" EXACT [OBOL:automatic] xref: EMAPA:36573 xref: FMA:84428 xref: MA:0002833 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: part_of UBERON:0002511 ! trabecula carnea relationship: part_of UBERON:0002511 ! trabecula carnea [Term] id: UBERON:0003457 name: head bone namespace: uberon def: "A bone that is part of a head [Automatically generated definition]." [OBOL:automatic] comment: Different sources vary regarding which bones are craniofacial; e.g. hyoid bone subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "adult head bone" EXACT [OBOL:automatic] synonym: "adult head bone organ" EXACT [OBOL:automatic] synonym: "bone of adult head" EXACT [OBOL:automatic] synonym: "bone of head" EXACT [OBOL:automatic] synonym: "bone organ of adult head" EXACT [OBOL:automatic] synonym: "bone organ of head" EXACT [OBOL:automatic] synonym: "craniofacial bone" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "head bone organ" EXACT [OBOL:automatic] xref: EMAPA:35996 xref: MA:0000576 xref: SCTID:118646007 is_a: UBERON:0007914 ! bone of craniocervical region intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] id: UBERON:0003458 name: neck bone namespace: uberon def: "A bone that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bone of neck" EXACT [OBOL:automatic] synonym: "bone of neck (volume)" EXACT [OBOL:automatic] synonym: "bone organ of neck" EXACT [OBOL:automatic] synonym: "bone organ of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) bone" EXACT [OBOL:automatic] synonym: "neck (volume) bone organ" EXACT [OBOL:automatic] synonym: "neck bone organ" EXACT [OBOL:automatic] xref: EMAPA:37246 {source="MA:th"} xref: MA:0000584 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003462 name: facial bone namespace: uberon def: "A bone that is part of a facial skeleton [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bone of facial skeleton" EXACT [OBOL:automatic] synonym: "bone of viscerocranium" RELATED [OBOL:automatic] synonym: "facial bone" EXACT [EMAPA:19019] synonym: "facial skeleton bone" EXACT [OBOL:automatic] synonym: "viscerocranium bone" RELATED [OBOL:automatic] xref: EMAPA:19019 xref: EMAPA:35924 xref: MA:0001482 xref: MA:0003159 xref: MESH:D005147 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0001-9439-5346", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: NCIT:C63706 xref: SCTID:181799005 xref: UMLS:C0015455 {source="ncithesaurus:Facial_Bone"} is_a: UBERON:0003457 ! head bone intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0011156 ! facial skeleton relationship: part_of UBERON:0011156 {source="MA"} ! facial skeleton property_value: editor_note "test whether 'facial bone' is an exact synonym" xsd:string [Term] id: UBERON:0003463 name: trunk bone namespace: uberon def: "A bone that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bone of torso" EXACT [OBOL:automatic] synonym: "bone of trunk" EXACT [OBOL:automatic] synonym: "bone organ of torso" EXACT [OBOL:automatic] synonym: "bone organ of trunk" EXACT [OBOL:automatic] synonym: "torso bone" EXACT [OBOL:automatic] synonym: "torso bone organ" EXACT [OBOL:automatic] synonym: "trunk bone organ" EXACT [OBOL:automatic] xref: EMAPA:36583 xref: MA:0000512 xref: SCTID:427358002 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003469 name: respiratory system artery namespace: uberon def: "An artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:37569 {source="MA:th"} xref: MA:0001804 is_a: UBERON:0001637 ! artery is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003470 name: artery of upper lip namespace: uberon def: "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." [Wikipedia:Superior_labial_artery] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "arteria labialis superior" EXACT OMO:0003011 [Wikipedia:Superior_labial_artery] synonym: "ramus labialis superior arteriae facialis" EXACT OMO:0003011 [Wikipedia:Superior_labial_artery] synonym: "superior labial artery" EXACT [FMA:49570] synonym: "superior labial branch of facial artery" EXACT [FMA:49570] xref: EMAPA:37430 {source="MA:th"} xref: FMA:49570 xref: MA:0001917 xref: SCTID:145137009 xref: Wikipedia:Superior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0001834 ! upper lip relationship: connecting_branch_of UBERON:0001612 {source="FMA"} ! facial artery relationship: vessel_supplies_blood_to UBERON:0001834 ! upper lip property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003471 name: artery of lower lip namespace: uberon def: "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." [Wikipedia:Inferior_labial_artery] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "arteria labialis inferior" EXACT OMO:0003011 [Wikipedia:Inferior_labial_artery] synonym: "inferior labial artery" EXACT [FMA:49567] synonym: "inferior labial branch of facial artery" EXACT [FMA:49567] synonym: "ramus labialis inferior (arteria facialis)" EXACT [FMA:TA] synonym: "ramus labialis inferior arteriae facialis" EXACT OMO:0003011 [Wikipedia:Inferior_labial_artery] xref: EMAPA:37429 {source="MA:th"} xref: FMA:49567 xref: MA:0001916 xref: SCTID:145036002 xref: Wikipedia:Inferior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: vessel_supplies_blood_to UBERON:0001835 ! lower lip relationship: connecting_branch_of UBERON:0001612 {source="FMA"} ! facial artery relationship: vessel_supplies_blood_to UBERON:0001835 ! lower lip property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003473 name: thoracic cavity artery namespace: uberon def: "An artery that is part of a thoracic cavity[cjm]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376] subset: human_subset subset: mouse_subset synonym: "thoracic artery" RELATED [MESH:A07.231.114.891] xref: EMAPA:37241 {source="MA:th"} xref: MA:0001902 xref: MESH:D013895 is_a: UBERON:0001637 ! artery is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: located_in UBERON:0002224 ! thoracic cavity property_value: UBPROP:0000012 "in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity" xsd:string {external_ontology="MA"} [Term] id: UBERON:0003476 name: respiratory system venous blood vessel namespace: uberon def: "A vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius vein" EXACT [OBOL:automatic] synonym: "respiratory system vein" EXACT [OBOL:automatic] synonym: "vein of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "vein of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37584 {source="MA:th"} xref: MA:0001809 xref: MA:0001810 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0001004 ! respiratory system relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0001004 ! respiratory system [Term] id: UBERON:0003477 name: vein of upper lip namespace: uberon def: "The inferior labial vein is the vein receiving blood from the upper lip." [Wikipedia:Superior_labial_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "superior labial vein" EXACT [FMA:52538] synonym: "upper lip vein" EXACT [OBOL:automatic] synonym: "vena labialis superior" EXACT OMO:0003011 [] xref: EMAPA:37204 {source="MA:th"} xref: FMA:52538 xref: MA:0002255 xref: SCTID:422755007 xref: Wikipedia:Superior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0001834 ! upper lip relationship: vessel_drains_blood_from UBERON:0001834 ! upper lip property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003478 name: vein of lower lip namespace: uberon def: "The inferior labial vein is the vein receiving blood from the lower lip." [Wikipedia:Inferior_labial_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "inferior labial vein" EXACT [FMA:52541] synonym: "lower lip vein" EXACT [OBOL:automatic] synonym: "vena labialis inferior" EXACT OMO:0003011 [] synonym: "venae labiales inferiores" RELATED OMO:0003011 [Wikipedia:Inferior_labial_vein] xref: EMAPA:37202 {source="MA:th"} xref: FMA:52541 xref: MA:0002253 xref: SCTID:422955002 xref: Wikipedia:Inferior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: vessel_drains_blood_from UBERON:0001835 ! lower lip relationship: vessel_drains_blood_from UBERON:0001835 ! lower lip property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003479 name: thoracic cavity vein namespace: uberon def: "A vein that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavity of chest vein" EXACT [OBOL:automatic] synonym: "cavity of thorax vein" EXACT [OBOL:automatic] synonym: "chest cavity vein" EXACT [OBOL:automatic] synonym: "pectoral cavity vein" EXACT [OBOL:automatic] synonym: "vein of cavity of chest" EXACT [OBOL:automatic] synonym: "vein of cavity of thorax" EXACT [OBOL:automatic] synonym: "vein of chest cavity" EXACT [OBOL:automatic] synonym: "vein of pectoral cavity" EXACT [OBOL:automatic] synonym: "vein of thoracic cavity" EXACT [OBOL:automatic] xref: EMAPA:37242 {source="MA:th"} xref: MA:0001903 is_a: UBERON:0001638 ! vein is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: located_in UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0003481 name: tail vein namespace: uberon def: "A vein that is part of a tail [Automatically generated definition]." [OBOL:automatic, Wikipedia:Tail_vein] subset: mouse_subset synonym: "caudal vein" RELATED [Wikipedia:Tail_vein] synonym: "post-vent region vein" EXACT [OBOL:automatic] synonym: "vein of post-vent region" EXACT [OBOL:automatic] synonym: "vein of tail" EXACT [OBOL:automatic] xref: AAO:0011105 xref: EMAPA:37761 {source="MA:th"} xref: MA:0002233 xref: Wikipedia:Tail_vein xref: XAO:0000393 is_a: UBERON:0001638 ! vein is_a: UBERON:0003524 ! tail blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0007812 ! post-anal tail property_value: editor_note "see also caudal vein" xsd:string [Term] id: UBERON:0003489 name: respiratory system capillary endothelium namespace: uberon def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius blood capillary endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of capillary vessel" EXACT [OBOL:automatic] synonym: "blood capillary endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood capillary endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "capillary endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "capillary vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of capillary of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system blood capillary endothelium" EXACT [OBOL:automatic] synonym: "respiratory system capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of capillary" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of capillary vessel" EXACT [OBOL:automatic] xref: EMAPA:37575 {source="MA:th"} xref: MA:0001808 is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001915 ! endothelium of capillary intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003526 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! respiratory system capillary [Term] id: UBERON:0003494 name: respiratory system venule namespace: uberon def: "A venule that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius venule" EXACT [OBOL:automatic] synonym: "venule of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "venule of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37587 {source="MA:th"} xref: MA:0001813 is_a: UBERON:0001979 ! venule is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001979 ! venule intersection_of: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003495 name: respiratory system arteriole namespace: uberon def: "An arteriole that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:37568 {source="MA:th"} xref: MA:0001803 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001980 ! arteriole intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003469 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! respiratory system artery [Term] id: UBERON:0003496 name: head blood vessel namespace: uberon def: "A blood vessel that is part of a head [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "adult head blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of adult head" EXACT [OBOL:automatic] synonym: "blood vessel of head" EXACT [OBOL:automatic] xref: EMAPA:36610 xref: MA:0000575 xref: SCTID:127865000 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0011362 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! cranial blood vasculature [Term] id: UBERON:0003497 name: abdomen blood vessel namespace: uberon def: "A blood vessel that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of abdomen" EXACT [OBOL:automatic] xref: MA:0000518 is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen property_value: seeAlso UBERON:0012254 xsd:string {notes="abdominal aorta artery"} [Term] id: UBERON:0003498 name: heart blood vessel namespace: uberon def: "A blood vessel that is part of a heart [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel of heart" EXACT [OBOL:automatic] synonym: "cardiac blood vessel" RELATED [EMAPA:35397] xref: EMAPA:35397 xref: MA:0002483 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0005985 ! coronary vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0018674 ! heart vasculature [Term] id: UBERON:0003499 name: brain blood vessel namespace: uberon def: "A blood vessel that is part of a brain [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel of brain" EXACT [OBOL:automatic] xref: EMAPA:35182 xref: MA:0002769 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0008998 ! vasculature of brain [Term] id: UBERON:0003500 name: corneal blood vessel namespace: uberon def: "A blood vessel that is part of a cornea [Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764] subset: human_subset subset: mouse_subset synonym: "blood vessel of cornea" EXACT [OBOL:automatic] synonym: "cornea blood vessel" EXACT [OBOL:automatic] xref: EMAPA:36611 xref: MA:0001241 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea property_value: editor_note "follow up on tracker item" xsd:string property_value: RO:0002175 NCBITaxon:9775 {source="PMID:17051153"} [Term] id: UBERON:0003501 name: retina blood vessel namespace: uberon def: "A blood vessel that is part of a retina [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel of inner layer of eyeball" EXACT [OBOL:automatic] synonym: "blood vessel of retina" EXACT [OBOL:automatic] synonym: "blood vessel of tunica interna of eyeball" EXACT [OBOL:automatic] synonym: "inner layer of eyeball blood vessel" EXACT [OBOL:automatic] synonym: "retinal blood vessel" EXACT [OBOL:automatic] synonym: "tunica interna of eyeball blood vessel" EXACT [OBOL:automatic] xref: EMAPA:36520 xref: GAID:509 xref: MA:0001317 xref: MESH:D012171 xref: SCTID:280692003 xref: XAO:0004153 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000966 ! retina relationship: contributes_to_morphology_of UBERON:0000966 ! retina relationship: part_of UBERON:0004864 ! vasculature of retina [Term] id: UBERON:0003502 name: neck blood vessel namespace: uberon def: "A blood vessel that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of neck" EXACT [OBOL:automatic] synonym: "blood vessel of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37236 {source="MA:th"} xref: MA:0000583 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003504 name: respiratory system blood vessel namespace: uberon def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:35731 xref: EMAPA:35995 xref: MA:0001799 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003505 name: trachea blood vessel namespace: uberon alt_id: UBERON:0003525 def: "A blood vessel that is part of a trachea." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of trachea" EXACT [OBOL:automatic] xref: EMAPA:35874 xref: MA:0001852 is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0003509 name: arterial blood vessel namespace: uberon def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." [https://orcid.org/0000-0002-6601-2165] comment: only in MA - supertype of artery, arteriole, aorta. subset: human_subset subset: mouse_subset subset: pheno_slim xref: EMAPA:35144 xref: MA:0000061 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0004572 ! arterial system relationship: part_of UBERON:0004572 ! arterial system [Term] id: UBERON:0003511 name: iris blood vessel namespace: uberon def: "A blood vessel that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "blood vessel of iris" EXACT [OBOL:automatic] xref: EMAPA:37387 {source="MA:th"} xref: MA:0001290 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0004118 ! vasculature of iris [Term] id: UBERON:0003512 name: lung blood vessel namespace: uberon def: "A blood vessel that is part of a lung [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel of lung" EXACT [OBOL:automatic] synonym: "pulmonary vascular element" RELATED [EMAPA:32867] xref: EMAPA:32867 xref: MA:0002457 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002048 ! lung relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: UBERON:0003513 name: trunk blood vessel namespace: uberon def: "A blood vessel that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of torso" EXACT [OBOL:automatic] synonym: "blood vessel of trunk" EXACT [OBOL:automatic] synonym: "torso blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37237 {source="MA:th"} xref: MA:0000511 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003519 name: thoracic cavity blood vessel namespace: uberon def: "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of cavity of chest" EXACT [OBOL:automatic] synonym: "blood vessel of cavity of thorax" EXACT [OBOL:automatic] synonym: "blood vessel of chest cavity" EXACT [OBOL:automatic] synonym: "blood vessel of pectoral cavity" EXACT [OBOL:automatic] synonym: "blood vessel of thoracic cavity" EXACT [OBOL:automatic] synonym: "cavity of chest blood vessel" EXACT [OBOL:automatic] synonym: "cavity of thorax blood vessel" EXACT [OBOL:automatic] synonym: "chest cavity blood vessel" EXACT [OBOL:automatic] synonym: "pectoral cavity blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37240 {source="MA:th"} xref: MA:0000554 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: located_in UBERON:0002224 ! thoracic cavity relationship: located_in UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0003524 name: tail blood vessel namespace: uberon def: "A blood vessel that is part of a tail [Automatically generated definition]." [OBOL:automatic] subset: mouse_subset synonym: "blood vessel of post-vent region" EXACT [OBOL:automatic] synonym: "blood vessel of tail" EXACT [OBOL:automatic] synonym: "post-vent region blood vessel" EXACT [OBOL:automatic] xref: EMAPA:35848 xref: MA:0000695 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0007812 ! post-anal tail relationship: part_of UBERON:0007812 ! post-anal tail [Term] id: UBERON:0003526 name: respiratory system capillary namespace: uberon def: "A capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius blood capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary vessel" EXACT [OBOL:automatic] synonym: "blood capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood capillary of respiratory system" EXACT [OBOL:automatic] synonym: "capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary of respiratory system" EXACT [OBOL:automatic] synonym: "capillary vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system blood capillary" EXACT [OBOL:automatic] synonym: "respiratory system capillary vessel" EXACT [OBOL:automatic] xref: EMAPA:37574 {source="MA:th"} xref: MA:0001807 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003528 name: brain gray matter namespace: uberon def: "A gray matter that is part of a brain [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "brain grey matter" EXACT [MA:0000810] synonym: "brain grey substance" EXACT [OBOL:automatic] synonym: "gray matter of brain" EXACT [OBOL:automatic] synonym: "grey matter of brain" EXACT [OBOL:automatic] synonym: "grey substance of brain" EXACT [OBOL:automatic] xref: EMAPA:35184 xref: MA:0000810 xref: NCIT:C49333 xref: UMLS:C1707348 {source="ncithesaurus:Cerebral_Gray_Matter"} is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain [Term] id: UBERON:0003534 name: tail skin namespace: uberon def: "A zone of skin that is part of a tail [Automatically generated definition]." [OBOL:automatic] subset: mouse_subset subset: pheno_slim synonym: "post-vent region skin" EXACT [OBOL:automatic] synonym: "skin of post-vent region" EXACT [OBOL:automatic] synonym: "skin of tail" EXACT [OBOL:automatic] xref: EMAPA:36502 xref: MA:0000700 xref: SCTID:67214004 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0007812 ! post-anal tail relationship: part_of UBERON:0007812 ! post-anal tail [Term] id: UBERON:0003566 name: head connective tissue namespace: uberon def: "A portion of connective tissue that is part of a head [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "adult head connective tissue" EXACT [OBOL:automatic] synonym: "adult head portion of connective tissue" EXACT [OBOL:automatic] synonym: "adult head textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of adult head" EXACT [OBOL:automatic] synonym: "connective tissue of head" EXACT [OBOL:automatic] synonym: "head portion of connective tissue" EXACT [OBOL:automatic] synonym: "head textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of adult head" EXACT [OBOL:automatic] synonym: "portion of connective tissue of head" EXACT [OBOL:automatic] synonym: "textus connectivus of adult head" EXACT [OBOL:automatic] synonym: "textus connectivus of head" EXACT [OBOL:automatic] xref: MA:0000577 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000033 ! head relationship: develops_from UBERON:0005253 ! head mesenchyme relationship: part_of UBERON:0000033 ! head relationship: transformation_of UBERON:0005253 ! head mesenchyme [Term] id: UBERON:0003567 name: abdomen connective tissue namespace: uberon def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdomen portion of connective tissue" EXACT [OBOL:automatic] synonym: "abdomen textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of abdomen" EXACT [OBOL:automatic] synonym: "portion of connective tissue of abdomen" EXACT [OBOL:automatic] synonym: "textus connectivus of abdomen" EXACT [OBOL:automatic] xref: MA:0000519 is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003568 name: neck connective tissue namespace: uberon def: "A portion of connective tissue that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "connective tissue of neck" EXACT [OBOL:automatic] synonym: "connective tissue of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) connective tissue" EXACT [OBOL:automatic] synonym: "neck (volume) portion of connective tissue" EXACT [OBOL:automatic] synonym: "neck (volume) textus connectivus" EXACT [OBOL:automatic] synonym: "neck portion of connective tissue" EXACT [OBOL:automatic] synonym: "neck textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of neck" EXACT [OBOL:automatic] synonym: "portion of connective tissue of neck (volume)" EXACT [OBOL:automatic] synonym: "textus connectivus of neck" EXACT [OBOL:automatic] synonym: "textus connectivus of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37250 {source="MA:th"} xref: MA:0000585 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003570 name: respiratory system connective tissue namespace: uberon def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius portion of connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "portion of connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "portion of connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system portion of connective tissue" EXACT [OBOL:automatic] synonym: "respiratory system textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "textus connectivus of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:35968 xref: EMAPA:35977 xref: MA:0001814 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003571 name: trachea connective tissue namespace: uberon def: "A portion of connective tissue that is part of a trachea." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "connective tissue of trachea" EXACT [OBOL:automatic] synonym: "connective tissue of windpipe" EXACT [OBOL:automatic] xref: EMAPA:35876 xref: MA:0001853 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0009505 ! mesenchyme of trachea relationship: part_of UBERON:0003126 ! trachea relationship: transformation_of UBERON:0009505 ! mesenchyme of trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003580 name: lower respiratory tract connective tissue namespace: uberon def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "connective tissue of lower respiratory tract" EXACT [OBOL:automatic] synonym: "lower respiratory tract portion of connective tissue" EXACT [OBOL:automatic] synonym: "lower respiratory tract textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of lower respiratory tract" EXACT [OBOL:automatic] synonym: "textus connectivus of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:37548 {source="MA:th"} xref: MA:0002409 is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0003585 name: dermis connective tissue namespace: uberon def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "connective tissue of dermis" EXACT [OBOL:automatic] synonym: "dermis portion of connective tissue" EXACT [OBOL:automatic] synonym: "dermis textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of dermis" EXACT [OBOL:automatic] synonym: "textus connectivus of dermis" EXACT [OBOL:automatic] xref: EMAPA:36509 xref: MA:0000799 is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002067 ! dermis relationship: develops_from UBERON:0004016 ! dermatome relationship: part_of UBERON:0002067 ! dermis [Term] id: UBERON:0003586 name: trunk connective tissue namespace: uberon def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "connective tissue of torso" EXACT [OBOL:automatic] synonym: "connective tissue of trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of torso" EXACT [OBOL:automatic] synonym: "portion of connective tissue of trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of torso" EXACT [OBOL:automatic] synonym: "textus connectivus of trunk" EXACT [OBOL:automatic] synonym: "torso connective tissue" EXACT [OBOL:automatic] synonym: "torso portion of connective tissue" EXACT [OBOL:automatic] synonym: "torso textus connectivus" EXACT [OBOL:automatic] synonym: "trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "trunk textus connectivus" EXACT [OBOL:automatic] xref: EMAPA:37252 {source="MA:th"} xref: MA:0000513 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] id: UBERON:0003592 name: bronchus connective tissue namespace: uberon def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bronchi connective tissue" EXACT [OBOL:automatic] synonym: "bronchi portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchi textus connectivus" EXACT [OBOL:automatic] synonym: "bronchial connective tissue" RELATED [EMAPA:35193] synonym: "bronchial mesenchyme" RELATED [EMAPA:32690] synonym: "bronchial trunk connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk textus connectivus" EXACT [OBOL:automatic] synonym: "bronchus portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchus textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchi" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchial trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchus" EXACT [OBOL:automatic] xref: EMAPA:32690 xref: EMAPA:35193 xref: MA:0001831 xref: NCIT:C49210 xref: UMLS:C1707052 {source="ncithesaurus:Bronchus_Connective_Tissue"} is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0003593 name: thoracic cavity connective tissue namespace: uberon def: "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavity of chest connective tissue" EXACT [OBOL:automatic] synonym: "cavity of chest portion of connective tissue" EXACT [OBOL:automatic] synonym: "cavity of chest textus connectivus" EXACT [OBOL:automatic] synonym: "cavity of thorax connective tissue" EXACT [OBOL:automatic] synonym: "cavity of thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "cavity of thorax textus connectivus" EXACT [OBOL:automatic] synonym: "chest cavity connective tissue" EXACT [OBOL:automatic] synonym: "chest cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "chest cavity textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of cavity of chest" EXACT [OBOL:automatic] synonym: "connective tissue of cavity of thorax" EXACT [OBOL:automatic] synonym: "connective tissue of chest cavity" EXACT [OBOL:automatic] synonym: "connective tissue of pectoral cavity" EXACT [OBOL:automatic] synonym: "connective tissue of thoracic cavity" EXACT [OBOL:automatic] synonym: "pectoral cavity connective tissue" EXACT [OBOL:automatic] synonym: "pectoral cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "pectoral cavity textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of cavity of chest" EXACT [OBOL:automatic] synonym: "portion of connective tissue of cavity of thorax" EXACT [OBOL:automatic] synonym: "portion of connective tissue of chest cavity" EXACT [OBOL:automatic] synonym: "portion of connective tissue of pectoral cavity" EXACT [OBOL:automatic] synonym: "portion of connective tissue of thoracic cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of cavity of chest" EXACT [OBOL:automatic] synonym: "textus connectivus of cavity of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of chest cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of pectoral cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of thoracic cavity" EXACT [OBOL:automatic] synonym: "thoracic cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "thoracic cavity textus connectivus" EXACT [OBOL:automatic] xref: EMAPA:37255 {source="MA:th"} xref: MA:0000555 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: located_in UBERON:0002224 ! thoracic cavity relationship: located_in UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0003599 name: tail connective tissue namespace: uberon def: "A portion of connective tissue that is part of a tail [Automatically generated definition]." [OBOL:automatic] subset: mouse_subset synonym: "connective tissue of post-vent region" EXACT [OBOL:automatic] synonym: "connective tissue of tail" EXACT [OBOL:automatic] synonym: "portion of connective tissue of post-vent region" EXACT [OBOL:automatic] synonym: "portion of connective tissue of tail" EXACT [OBOL:automatic] synonym: "post-vent region connective tissue" EXACT [OBOL:automatic] synonym: "post-vent region portion of connective tissue" EXACT [OBOL:automatic] synonym: "post-vent region textus connectivus" EXACT [OBOL:automatic] synonym: "tail portion of connective tissue" EXACT [OBOL:automatic] synonym: "tail textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of post-vent region" EXACT [OBOL:automatic] synonym: "textus connectivus of tail" EXACT [OBOL:automatic] xref: EMAPA:16749 xref: MA:0000697 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0007812 ! post-anal tail relationship: part_of UBERON:0007812 ! post-anal tail [Term] id: UBERON:0003601 name: neck cartilage namespace: uberon def: "A cartilage that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cartilage of neck" EXACT [OBOL:automatic] synonym: "cartilage of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) cartilage" EXACT [OBOL:automatic] xref: EMAPA:37251 {source="MA:th"} xref: MA:0000586 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck [Term] id: UBERON:0003603 name: lower respiratory tract cartilage namespace: uberon def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cartilage of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:37547 {source="MA:th"} xref: MA:0001819 xref: NCIT:C49256 xref: UMLS:C1708759 {source="ncithesaurus:Lower_Respiratory_Tract_Cartilage"} is_a: UBERON:0003406 ! cartilage of respiratory system intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0003604 name: trachea cartilage namespace: uberon def: "The ring-shaped cartilaginous structures that support the trachea." [http://orcid.org/0000-0002-6601-2165, J:97123, MGI:smb, MP:0003120] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cartilage of the trachea" RELATED [Wikipedia:Tracheal_rings] synonym: "cartilage of trachea" EXACT [OBOL:automatic] synonym: "cartilage of windpipe" EXACT [OBOL:automatic] synonym: "cartilagines tracheales" RELATED OMO:0003011 [Wikipedia:Tracheal_rings] synonym: "cartilaginous ring of trachea" EXACT [EMAPA:18699] synonym: "cartilaginous trachea cartilage" EXACT [OBOL:automatic] synonym: "cartilago trachealis" EXACT [FMA:7434] synonym: "ring of the trachea" RELATED [Wikipedia:Tracheal_rings] synonym: "trachea ring" RELATED [] synonym: "tracheal cartilage" EXACT [FMA:7434] synonym: "tracheal ring" RELATED [Wikipedia:Tracheal_rings] synonym: "windpipe cartilage" EXACT [OBOL:automatic] xref: EMAPA:18699 xref: EMAPA:35875 xref: FMA:7434 xref: MA:0001857 xref: NCIT:C49304 xref: SCTID:278979006 xref: UMLS:C1710456 {source="ncithesaurus:Trachea_Cartilage"} xref: Wikipedia:Tracheal_rings is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0007267 ! trachea pre-cartilage rings relationship: part_of UBERON:0003126 ! trachea property_value: editor_note "check whether to classify as part of splanchoncranium" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-female/v1.1/assets/3d-vh-f-trachea.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-male/v1.1/assets/3d-vh-m-trachea.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in mammals the rings are incomplete, in avians the rings are complete." xsd:string [Term] id: UBERON:0003605 name: eye skin gland namespace: uberon def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: organ_slim synonym: "camera-type eye skin gland" EXACT [OBOL:automatic] synonym: "camera-type eye skin glands" EXACT [OBOL:automatic] synonym: "camera-type eye skin glands set" EXACT [OBOL:automatic] synonym: "skin gland of camera-type eye" EXACT [OBOL:automatic] synonym: "skin gland of vertebrate eye" EXACT [OBOL:automatic] synonym: "skin glands of camera-type eye" EXACT [OBOL:automatic] synonym: "skin glands of vertebrate eye" EXACT [OBOL:automatic] synonym: "skin glands set of camera-type eye" EXACT [OBOL:automatic] synonym: "skin glands set of vertebrate eye" EXACT [OBOL:automatic] synonym: "vertebrate eye skin gland" EXACT [OBOL:automatic] synonym: "vertebrate eye skin glands" EXACT [OBOL:automatic] synonym: "vertebrate eye skin glands set" EXACT [OBOL:automatic] xref: EMAPA:37530 {source="MA:th"} xref: MA:0002451 is_a: UBERON:0002419 ! skin gland is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region intersection_of: UBERON:0002419 ! skin gland intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003609 name: aorta elastic tissue namespace: uberon def: "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." [MP:0009862] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "adult aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "adult aorta elastic tissue" EXACT [OBOL:automatic] synonym: "adult aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "aorta elastic lamina" EXACT [MP:0009862] synonym: "aorta elastic laminae" EXACT OMO:0003004 [MP:0009862] synonym: "aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "dorsal aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "dorsal aorta elastic tissue" EXACT [OBOL:automatic] synonym: "dorsal aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of adult aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of dorsal aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "elastic tissue of adult aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of dorsal aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of adult aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of dorsal aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "trunk of aortic tree elastic connective tissue" EXACT [OBOL:automatic] synonym: "trunk of aortic tree elastic tissue" EXACT [OBOL:automatic] synonym: "trunk of aortic tree textus connectivus elasticus" EXACT [OBOL:automatic] xref: MA:0002859 is_a: UBERON:0003614 ! blood vessel elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0003610 name: heart elastic tissue namespace: uberon def: "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." [MP:0009863] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cardiac elastic tissue" EXACT [MP:0009863] synonym: "elastic connective tissue of heart" EXACT [OBOL:automatic] synonym: "elastic tissue of heart" EXACT [OBOL:automatic] synonym: "heart elastic connective tissue" EXACT [OBOL:automatic] synonym: "heart textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of heart" EXACT [OBOL:automatic] xref: MA:0002858 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0003837 ! thoracic segment connective tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0003611 name: respiratory system elastic tissue namespace: uberon def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius elastic connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius elastic tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "elastic connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "elastic tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "elastic tissue of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system elastic connective tissue" EXACT [OBOL:automatic] synonym: "respiratory system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37579 {source="MA:th"} xref: MA:0001820 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0004777 ! respiratory system submucosa [Term] id: UBERON:0003613 name: cardiovascular system elastic tissue namespace: uberon def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cardiovascular system elastic connective tissue" EXACT [OBOL:automatic] synonym: "cardiovascular system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "circulatory system elastic connective tissue" EXACT [OBOL:automatic] synonym: "circulatory system elastic tissue" EXACT [OBOL:automatic] synonym: "circulatory system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of cardiovascular system" EXACT [OBOL:automatic] synonym: "elastic connective tissue of circulatory system" EXACT [OBOL:automatic] synonym: "elastic tissue of cardiovascular system" EXACT [OBOL:automatic] synonym: "elastic tissue of circulatory system" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of cardiovascular system" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of circulatory system" EXACT [OBOL:automatic] xref: MA:0002857 is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001009 ! circulatory system relationship: part_of UBERON:0004535 ! cardiovascular system [Term] id: UBERON:0003614 name: blood vessel elastic tissue namespace: uberon def: "Elastic tissue layer that lines a blood vessel layer." [http://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel elastic connective tissue" EXACT [OBOL:automatic] synonym: "blood vessel textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of blood vessel" EXACT [OBOL:automatic] synonym: "elastic lamina" BROAD [MP:0006083] synonym: "elastic laminae" BROAD OMO:0003004 [MP:0006083] synonym: "elastic tissue of blood vessel" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of blood vessel" EXACT [OBOL:automatic] synonym: "vascular elastic lamina" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "vascular elastic laminae" EXACT OMO:0003004 [http://orcid.org/0000-0002-6601-2165] synonym: "vascular elastic tissue" EXACT [MP:0006083] xref: EMAPA:36300 xref: MA:0002856 is_a: UBERON:0003613 ! cardiovascular system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel [Term] id: UBERON:0003615 name: lung elastic tissue namespace: uberon def: "Elastic tissue that is part of a lung [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "elastic connective tissue of lung" EXACT [OBOL:automatic] synonym: "elastic tissue of lung" EXACT [OBOL:automatic] synonym: "lung elastic connective tissue" EXACT [OBOL:automatic] synonym: "lung textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "pulmonary elastic fiber" NARROW [http://orcid.org/0000-0002-6601-2165] synonym: "textus connectivus elasticus of lung" EXACT [OBOL:automatic] xref: MA:0002860 is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0002048 ! lung [Term] id: UBERON:0003616 name: bronchus elastic tissue namespace: uberon def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bronchi elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchi elastic tissue" EXACT [OBOL:automatic] synonym: "bronchi textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "bronchial trunk elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk elastic tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "bronchus elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchus textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchi" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchi" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchial trunk" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchus" EXACT [OBOL:automatic] xref: MA:0001838 xref: NCIT:C49211 xref: UMLS:C1707053 {source="ncithesaurus:Bronchus_Elastic_Tissue"} is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0001957 ! submucosa of bronchus [Term] id: UBERON:0003617 name: trachea elastic tissue namespace: uberon def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cartilaginous trachea elastic connective tissue" EXACT [OBOL:automatic] synonym: "cartilaginous trachea elastic tissue" EXACT [OBOL:automatic] synonym: "cartilaginous trachea textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "elastic connective tissue of vertebrate trachea" EXACT [OBOL:automatic] synonym: "elastic connective tissue of windpipe" EXACT [OBOL:automatic] synonym: "elastic tissue of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "elastic tissue of vertebrate trachea" EXACT [OBOL:automatic] synonym: "elastic tissue of windpipe" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of vertebrate trachea" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of windpipe" EXACT [OBOL:automatic] synonym: "vertebrate trachea elastic connective tissue" EXACT [OBOL:automatic] synonym: "vertebrate trachea elastic tissue" EXACT [OBOL:automatic] synonym: "vertebrate trachea textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "windpipe elastic connective tissue" EXACT [OBOL:automatic] synonym: "windpipe elastic tissue" EXACT [OBOL:automatic] synonym: "windpipe textus connectivus elasticus" EXACT [OBOL:automatic] xref: MA:0001861 is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0002202 ! submucosa of trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003618 name: aorta tunica media namespace: uberon def: "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." [MP:0009873] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "adult aorta tunica media" EXACT [OBOL:automatic] synonym: "dorsal aorta tunica media" EXACT [OBOL:automatic] synonym: "trunk of aortic tree tunica media" EXACT [OBOL:automatic] synonym: "tunica media of adult aorta" EXACT [OBOL:automatic] synonym: "tunica media of aorta" EXACT [OBOL:automatic] synonym: "tunica media of dorsal aorta" EXACT [OBOL:automatic] synonym: "tunica media of trunk of aortic tree" EXACT [OBOL:automatic] xref: EMAPA:35138 xref: FMA:74433 xref: MA:0002903 xref: SCTID:48467007 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: part_of UBERON:0000947 ! aorta relationship: contributes_to_morphology_of UBERON:0004663 ! aorta wall relationship: part_of UBERON:0004663 ! aorta wall [Term] id: UBERON:0003619 name: aorta tunica intima namespace: uberon def: "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." [MP:0009872] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "adult aorta tunica intima" EXACT [OBOL:automatic] synonym: "dorsal aorta tunica intima" EXACT [OBOL:automatic] synonym: "trunk of aortic tree tunica intima" EXACT [OBOL:automatic] synonym: "tunica intima of adult aorta" EXACT [OBOL:automatic] synonym: "tunica intima of aorta" EXACT [OBOL:automatic] synonym: "tunica intima of dorsal aorta" EXACT [OBOL:automatic] synonym: "tunica intima of trunk of aortic tree" EXACT [OBOL:automatic] xref: BTO:0005553 xref: EMAPA:35137 xref: FMA:74419 xref: MA:0002904 xref: SCTID:362031007 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima intersection_of: part_of UBERON:0000947 ! aorta relationship: contributes_to_morphology_of UBERON:0004663 ! aorta wall relationship: part_of UBERON:0004663 ! aorta wall [Term] id: UBERON:0003643 name: respiratory system arterial blood vessel namespace: uberon def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:37565 {source="MA:th"} xref: MA:0001800 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003509 ! arterial blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003665 name: post-anal tail muscle namespace: uberon def: "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." [OBOL:automatic] subset: mouse_subset synonym: "caudal muscle" EXACT [] synonym: "muscle organ of post-vent region" EXACT [OBOL:automatic] synonym: "muscle organ of tail" EXACT [OBOL:automatic] synonym: "post-vent region muscle organ" EXACT [OBOL:automatic] synonym: "tail muscle" EXACT [MA:0000699] synonym: "tail muscle organ" EXACT [OBOL:automatic] xref: AAO:0000081 xref: BTO:0001905 xref: EMAPA:37759 {source="MA:th"} xref: MA:0000699 xref: SCTID:113230005 is_a: UBERON:0004518 ! muscle of vertebral column intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: attaches_to UBERON:0001095 ! caudal vertebra relationship: attaches_to UBERON:0001095 ! caudal vertebra relationship: overlaps UBERON:0007812 ! post-anal tail property_value: UBPROP:0000012 "the BTO class may possibly refer to an invertebrate structure" xsd:string {external_ontology="BTO"} [Term] id: UBERON:0003684 name: abdominal cavity namespace: uberon def: "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." [UBERON:cjm] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "cavitas abdominis" RELATED OMO:0003011 [GAID:17, Wikipedia:Abdominal_cavity] synonym: "cavity of abdominal compartment" EXACT [FMA:12266] synonym: "cavity of compartment of abdomen" EXACT [FMA:12266] synonym: "space of abdominal compartment" EXACT [FMA:12266] xref: EFO:0000213 xref: EMAPA:36505 xref: FMA:12266 xref: GAID:17 xref: galen:AbdominalCavity xref: MA:0003057 xref: MESH:D034841 xref: NCIT:C12664 xref: SCTID:361294009 xref: UMLS:C0230168 {source="ncithesaurus:Abdominal_Cavity"} xref: Wikipedia:Abdominal_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: luminal_space_of UBERON:0000916 ! abdomen intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen relationship: luminal_space_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0035819 ! abdominopelvic cavity property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg xsd:anyURI property_value: UBPROP:0000012 "in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0003687 name: foramen magnum namespace: uberon def: "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." [Wikipedia:Foramen_magnum] comment: Design pattern notes: check whether this fits the foramen design pattern subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core xref: AAO:0010826 xref: BTO:0006035 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EMAPA:37868 {source="MA:th"} xref: FMA:75306 xref: GAID:228 xref: MESH:D005539 xref: NCIT:C12495 xref: SCTID:244679008 xref: TAO:0002045 xref: UMLS:C0016519 {source="ncithesaurus:Foramen_Magnum"} xref: Wikipedia:Foramen_magnum xref: ZFA:0005387 is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: conduit_for UBERON:0001896 ! medulla oblongata relationship: conduit_for UBERON:0001896 ! medulla oblongata relationship: located_in UBERON:0001676 ! occipital bone property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png xsd:anyURI property_value: UBPROP:0000001 "Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002045", ontology="TAO", source="TAO:wd"} [Term] id: UBERON:0003694 name: atlanto-axial joint namespace: uberon def: "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." [Wikipedia:Atlanto-axial_joint] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "articulatio atlantoaxialis" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "articulatio atlantoepistrophica" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "atlanto axial joint" EXACT [GAID:250] synonym: "atlantoaxial" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "atlantoaxial joint" EXACT [GAID:250] synonym: "lateral atlanto-axial joint" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "median atlanto-axial joint" RELATED [Wikipedia:Atlanto-axial_joint] xref: FMA:25524 xref: GAID:250 xref: MESH:D001268 xref: NCIT:C32157 xref: SCTID:361832004 xref: UMLS:C0004168 {source="ncithesaurus:Atlanto-axial_Joint"} xref: Wikipedia:Atlanto-axial_joint is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: connects UBERON:0001092 ! vertebral bone 1 intersection_of: connects UBERON:0001093 ! vertebral bone 2 relationship: connects UBERON:0001092 ! vertebral bone 1 relationship: connects UBERON:0001093 ! vertebral bone 2 relationship: part_of UBERON:0011138 ! postcranial axial skeletal system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png xsd:anyURI [Term] id: UBERON:0003697 name: abdominal wall namespace: uberon def: "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." [ncithesaurus:Abdominal_Wall] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "abdominal wall proper" RELATED [FMA:10429] synonym: "layers of the abdominal wall" RELATED [Wikipedia:Abdominal_wall] synonym: "paries abdominalis" EXACT [Wikipedia:Abdominal_wall] synonym: "paries abdominalis" RELATED OMO:0003011 [Wikipedia:Abdominal_wall] synonym: "wall of abdomen" EXACT [FMA:259054] synonym: "wall of abdomen proper" EXACT [FMA:10429] xref: EMAPA:37064 {source="MA:th"} xref: FMA:10429 xref: FMA:259054 xref: GAID:26 xref: MESH:D034861 xref: NCIT:C77608 xref: SCTID:181613000 xref: UMLS:C0836916 {source="ncithesaurus:Abdominal_Wall"} xref: Wikipedia:Abdominal_wall is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg xsd:anyURI [Term] id: UBERON:0003703 name: extrahepatic bile duct namespace: uberon def: "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." [MESH:A03.159.183.079] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "bile duct extrahepatic part" RELATED [MA:0002659] synonym: "extrahepatic biliary system" RELATED [GAID:281] xref: FMA:14678 xref: GAID:281 xref: MA:0002659 xref: MESH:D017734 xref: NCIT:C32573 xref: SCTID:276158002 xref: UMLS:C0206187 {source="ncithesaurus:Extrahepatic_Bile_Duct"} is_a: UBERON:0002394 ! bile duct property_value: editor_note "includes all the cystic duct, all the common bile duct and the extrahapetic part of the hepatic duct" xsd:string property_value: RO:0002171 UBERON:0002107 [Term] id: UBERON:0003704 name: intrahepatic bile duct namespace: uberon def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." [MESH:A03.159.183.158] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "bile duct intrahepatic part" EXACT [MA:0001630] synonym: "intrahepatic biliary system" RELATED [] xref: FMA:15766 xref: GAID:287 xref: MA:0001630 xref: MESH:D001653 xref: NCIT:C12677 xref: SCTID:362193005 xref: TAO:0005169 xref: UMLS:C0005401 {source="ncithesaurus:Intrahepatic_Bile_Duct"} xref: ZFA:0005169 is_a: UBERON:0002394 {source="FMA"} ! bile duct intersection_of: UBERON:0002394 ! bile duct intersection_of: part_of UBERON:0002107 ! liver relationship: contributes_to_morphology_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 {source="MA"} ! liver property_value: editor_note "includes the hepatic duct of the caudate lobe, and the intra- and inter- lobar bile ducts" xsd:string property_value: UBPROP:0000001 "Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005169", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0003711 name: brachiocephalic vein namespace: uberon def: "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." [Wikipedia:Brachiocephalic_vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "brachiocephalic venous tree" EXACT [FMA:4723] synonym: "innomiate vein" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "innominate trunk" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "innominate vein" EXACT [FMA:4723] synonym: "innominate vein" RELATED [GAID:529, Wikipedia:Brachiocephalic_vein] synonym: "innominate veins" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "vena brachiocephalica" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_vein] synonym: "venae anonyma" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_vein] xref: EHDAA2:0000182 xref: EHDAA:9868 xref: FMA:4723 xref: GAID:529 xref: galen:BrachiocephalicVein xref: MESH:D016121 xref: NCIT:C32816 xref: SCTID:181371003 xref: UMLS:C0006095 {source="ncithesaurus:Innominate_Vein"} xref: Wikipedia:Brachiocephalic_vein is_a: UBERON:0001638 ! vein relationship: connected_to UBERON:0001585 ! anterior vena cava relationship: part_of RO:0002577 ! system relationship: part_of UBERON:0007204 ! brachiocephalic vasculature property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003713 name: splenic vein namespace: uberon def: "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." [ncithesaurus:Splenic_Vein] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lienal vein" RELATED [MA:0002164, Wikipedia:Splenic_vein] synonym: "vena lienalis" RELATED OMO:0003011 [Wikipedia:Splenic_vein] synonym: "vena splenica" EXACT OMO:0003011 [FMA:14331, FMA:TA] xref: EMAPA:37226 {source="MA:th"} xref: FMA:14331 xref: GAID:541 xref: galen:SplenicVein xref: MA:0002164 xref: MESH:D013162 xref: NCIT:C33608 xref: SCTID:278029005 xref: UMLS:C0038001 {source="ncithesaurus:Splenic_Vein"} xref: Wikipedia:Splenic_vein is_a: UBERON:0001638 ! vein relationship: connected_to UBERON:0001639 ! hepatic portal vein relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003714 name: neural tissue namespace: uberon def: "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." [FMA:9642] subset: human_subset subset: mouse_subset synonym: "nerve tissue" EXACT [FMA:9642] synonym: "nervous tissue" EXACT [FMA:9642] synonym: "portion of neural tissue" EXACT [FMA:9642] xref: AAO:0000325 xref: AEO:0000123 xref: EHDAA2:0003123 xref: FMA:9642 xref: GAID:609 xref: MESH:D009417 xref: NCIT:C13052 xref: SCTID:91728009 xref: UMLS:C0027757 {source="ncithesaurus:Nervous_Tissue"} is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: has_part CL:0000125 ! glial cell intersection_of: has_part CL:0000540 ! neuron disjoint_from: UBERON:0004755 ! skeletal tissue relationship: has_part CL:0000125 ! glial cell relationship: has_part CL:0000540 ! neuron relationship: part_of UBERON:0001016 ! nervous system property_value: UBPROP:0000001 "One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000325", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000012 "FMA definition includes vasculature" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0003715 name: splanchnic nerve namespace: uberon def: "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." [MP:0008318] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "splanchnic nerves" RELATED [BAMS:spn] synonym: "visceral nerve" RELATED [Wikipedia:Splanchnic_nerves] xref: BAMS:spn xref: EMAPA:37959 {source="MA:th"} xref: FMA:5883 xref: GAID:800 xref: MESH:D013153 xref: SCTID:264198001 xref: Wikipedia:Splanchnic_nerves is_a: UBERON:0034729 ! sympathetic nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0000916 ! abdomen relationship: contributes_to_morphology_of UBERON:0000013 ! sympathetic nervous system relationship: innervates UBERON:0000916 ! abdomen property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "All carry sympathetic fibers except for the pelvic splanchnic nerves, which carry parasympathetic fibers" xsd:string [Term] id: UBERON:0003726 name: thoracic nerve namespace: uberon def: "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." [MESH:A08.800.800.720.800] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "nervi thoracici" RELATED OMO:0003011 [Wikipedia:Thoracic_nerves] synonym: "nervus thoracis" EXACT OMO:0003011 [FMA:5860, FMA:TA] synonym: "pectoral nerve" RELATED [GAID:857] synonym: "thoracic spinal nerve" EXACT [FMA:5860] xref: FMA:5860 xref: GAID:857 xref: MESH:D013900 xref: neuronames:1725 xref: SCTID:360498003 xref: Wikipedia:Thoracic_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0003038 ! thoracic spinal cord relationship: extends_fibers_into UBERON:0003038 ! thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003727 name: intercostal nerve namespace: uberon def: "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." [Wikipedia:Intercostal_nerves] subset: human_subset subset: mouse_subset synonym: "anterior ramus of thoracic nerve" EXACT [FMA:6028] synonym: "anterior ramus of thoracic spinal nerve" EXACT [FMA:6028] synonym: "nervi intercostales" RELATED OMO:0003011 [Wikipedia:Intercostal_nerves] synonym: "ramus anterior, nervus thoracicus" EXACT [FMA:6028] synonym: "thoracic anterior ramus" EXACT [FMA:6028] synonym: "ventral ramus of thoracic spinal nerve" EXACT [FMA:6028] xref: EMAPA:18227 xref: FMA:6028 xref: GAID:858 xref: MESH:D007367 xref: NCIT:C32825 xref: SCTID:279568001 xref: UMLS:C1285089 {source="ncithesaurus:Intercostal_Nerve"} xref: Wikipedia:Intercostal_nerves is_a: UBERON:0001780 ! spinal nerve property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png xsd:anyURI [Term] id: UBERON:0003729 name: mouth mucosa namespace: uberon def: "A mucous membrane that lines the mouth." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "buccal mucosa" RELATED [GAID:951] synonym: "mouth mucosa" EXACT [FMA:59660] synonym: "mouth mucous membrane" EXACT [OBOL:accepted] synonym: "mouth organ mucosa" EXACT [OBOL:accepted] synonym: "mucosa of mouth" EXACT [OBOL:accepted] synonym: "mucosal lining of mouth" RELATED [MA:0002794] synonym: "mucous membrane of mouth" EXACT [FMA:59660] synonym: "oral mucosa" RELATED [GAID:951] synonym: "oral mucous membrane" EXACT [] synonym: "oral part of viscerocranial mucosa" EXACT [FMA:59660] synonym: "tunica mucosa oris" EXACT OMO:0003011 [FMA:59660, FMA:TA] synonym: "tunica mucosa oris" RELATED OMO:0003011 [Wikipedia:Oral_mucosa] xref: BTO:0002860 xref: CALOHA:TS-0716 xref: EMAPA:26937 xref: FMA:59660 xref: GAID:951 xref: MA:0002794 xref: MESH:D009061 xref: NCIT:C77637 xref: UMLS:C0026639 {source="ncithesaurus:Oral_Mucosa"} xref: Wikipedia:Oral_mucosa is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000165 ! mouth relationship: bounding_layer_of UBERON:0000165 ! mouth relationship: continuous_with UBERON:0000355 ! pharyngeal mucosa relationship: continuous_with UBERON:0001458 ! skin of lip relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0000165 ! mouth property_value: IAO:0000232 "this is defined as any mucous membrane of the mouth - including palate, lips, uvula, etc. ncit split mouth/oral mucosa into lip and buccal. In future we may split into masticatory/keratinized (gingiva + hard palate) vs lining/non-keratinized (lips, cheeks, floor of mouth, soft palate). FMA distinguishes between mucosa of mouth and region of mouth (the latter including the buccal mucosa)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]." xsd:string {source="Wikipedia:Oral_mucosa"} [Term] id: UBERON:0003824 name: nerve of thoracic segment namespace: uberon def: "A nerve that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "nerve of thorax" EXACT [OBOL:automatic] synonym: "thoracic segment nerve" EXACT [MA:0000562] synonym: "thorax nerve" EXACT [OBOL:automatic] synonym: "upper body nerve" RELATED [MA:0000562] xref: EMAPA:37265 {source="MA:th"} xref: MA:0000562 xref: MESH:D013900 xref: SCTID:359876006 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003825 name: nerve of abdominal segment namespace: uberon def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment nerve" EXACT [MA:0000528] xref: EMAPA:37061 {source="MA:th"} xref: MA:0000528 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003827 name: thoracic segment bone namespace: uberon def: "A bone that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "bone of thorax" EXACT [OBOL:automatic] synonym: "bone organ of thorax" EXACT [OBOL:automatic] synonym: "thorax bone" EXACT [OBOL:automatic] synonym: "thorax bone organ" EXACT [OBOL:automatic] synonym: "upper body bone" RELATED [MA:0000559] xref: EMAPA:37247 {source="MA:th"} xref: MA:0000559 xref: SCTID:426649006 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003828 name: abdominal segment bone namespace: uberon def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment of trunk bone" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk bone organ" EXACT [OBOL:automatic] synonym: "bone of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "bone organ of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37058 {source="MA:th"} xref: MA:0000525 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003830 name: thoracic segment muscle namespace: uberon def: "Any muscle organ that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "muscle organ of thorax" EXACT [OBOL:automatic] synonym: "thorax muscle organ" EXACT [OBOL:automatic] synonym: "upper body muscle" RELATED [MA:0000561] xref: MA:0000561 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0004464 {source="prolog"} ! musculature of thorax [Term] id: UBERON:0003831 name: respiratory system muscle namespace: uberon def: "Any muscle organ that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "apparatus respiratorius muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "muscle organ of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system muscle organ" EXACT [OBOL:automatic] xref: EMAPA:35733 xref: MA:0001828 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0003832 name: esophagus muscle namespace: uberon def: "Any muscle organ that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "esophageal muscle" EXACT [] synonym: "esophagus muscle organ" EXACT [OBOL:automatic] synonym: "gullet muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of esophagus" EXACT [OBOL:automatic] synonym: "muscle organ of gullet" EXACT [OBOL:automatic] synonym: "muscle organ of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus muscle organ" EXACT [OBOL:automatic] xref: EMAPA:26983 xref: MA:0002682 xref: SCTID:360961009 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001096 {source="MA"} ! wall of esophagus property_value: editor_note "merge muscle and muscle layer?" xsd:string [Term] id: UBERON:0003833 name: abdominal segment muscle namespace: uberon def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment of trunk muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37060 {source="MA:th"} xref: MA:0000527 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003834 name: thoracic segment blood vessel namespace: uberon def: "A blood vessel that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of thorax" EXACT [OBOL:automatic] synonym: "thorax blood vessel" EXACT [OBOL:automatic] synonym: "upper body blood vessel" RELATED [MA:0000558] xref: EMAPA:37238 {source="MA:th"} xref: MA:0000558 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003835 name: abdominal segment blood vessel namespace: uberon def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment of trunk blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37057 {source="MA:th"} xref: MA:0000524 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003836 name: abdominal segment skin namespace: uberon def: "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment of trunk skin" EXACT [OBOL:automatic] synonym: "skin of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37063 {source="MA:th"} xref: FMA:264898 xref: MA:0000530 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003837 name: thoracic segment connective tissue namespace: uberon def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "connective tissue of thorax" EXACT [OBOL:automatic] synonym: "portion of connective tissue of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of thorax" EXACT [OBOL:automatic] synonym: "thorax connective tissue" EXACT [OBOL:automatic] synonym: "thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "thorax textus connectivus" EXACT [OBOL:automatic] synonym: "upper body connective tissue" RELATED [MA:0000560] xref: EMAPA:37253 {source="MA:th"} xref: MA:0000560 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0003838 name: abdominal segment connective tissue namespace: uberon def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "abdominal segment of trunk connective tissue" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37059 {source="MA:th"} xref: MA:0000526 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002417 ! abdominal segment of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0003842 name: neural tube lumen namespace: uberon alt_id: UBERON:0005713 def: "An anatomical space that surrounded_by a neural tube." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cavity of neural tube" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "central lumen" RELATED [] synonym: "lumen of neural tube" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "neural lumen" RELATED [EHDAA:2889] synonym: "neural tube neural lumen" EXACT [EHDAA2:0001269] synonym: "neurocoel" RELATED [VHOG:0001119] synonym: "prosencoel" NARROW [] xref: AAO:0011073 xref: EHDAA2:0001269 xref: EHDAA:2889 xref: EHDAA:914 xref: EMAPA:16167 xref: VHOG:0001119 xref: XAO:0000252 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: luminal_space_of UBERON:0001049 ! neural tube relationship: luminal_space_of UBERON:0001049 ! neural tube relationship: part_of UBERON:0001049 ! neural tube property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001119", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003848 name: gonadal vein namespace: uberon def: "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." [Wikipedia:Gonadal_vein] subset: human_subset subset: mouse_subset synonym: "gonad vein" EXACT [OBOL:automatic] synonym: "gonada vein" EXACT [OBOL:automatic] synonym: "vein of gonad" EXACT [OBOL:automatic] synonym: "vein of gonada" EXACT [OBOL:automatic] xref: EHDAA2:0000719 xref: EHDAA:8703 xref: SCTID:278192008 xref: VHOG:0001340 xref: Wikipedia:Gonadal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: attaches_to UBERON:0000991 ! gonad relationship: attaches_to UBERON:0000991 ! gonad relationship: part_of RO:0002577 ! system property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png xsd:anyURI [Term] id: UBERON:0003849 name: mesencephalic neural crest namespace: uberon def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." [OBOL:automatic] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "mesencephalic neural crest" EXACT [ZFA:0000935] synonym: "neural crest midbrain" EXACT [ZFA:0000935] xref: EFO:0003591 xref: EHDAA2:0001101 xref: EHDAA:360 xref: TAO:0000935 xref: VHOG:0000796 xref: ZFA:0000935 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: has_potential_to_developmentally_contribute_to UBERON:0001891 ! midbrain relationship: has_potential_to_developmentally_contribute_to UBERON:0001891 ! midbrain property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000796", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003852 name: rhombencephalon neural crest namespace: uberon def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "neural crest hindbrain" EXACT [ZFA:0007063] synonym: "rhombencephalic neural crest" EXACT [ZFA:0007063] synonym: "rhombomere neural crest" RELATED [EMAPA:35747] xref: EHDAA2:0001628 xref: EHDAA:362 xref: EMAPA:35747 xref: TAO:0007063 xref: VHOG:0001210 xref: ZFA:0007063 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: has_potential_to_developmentally_contribute_to UBERON:0002028 ! hindbrain relationship: has_potential_to_developmentally_contribute_to UBERON:0002028 ! hindbrain property_value: UBPROP:0000001 "Cranial neural crest that is part of the hindbrain.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007063", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001210", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003853 name: spinal cord neural crest namespace: uberon def: "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "neural crest spinal cord" EXACT [VHOG:0001006] synonym: "spinal neural crest" RELATED [VHOG:0001006] xref: EHDAA:696 xref: EMAPA:16163 xref: EMAPA:16881 xref: VHOG:0001006 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: has_potential_to_developmentally_contribute_to UBERON:0002240 ! spinal cord relationship: has_potential_to_developmentally_contribute_to UBERON:0002240 ! spinal cord property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001006", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003854 name: spinal cord neural plate namespace: uberon def: "A neural plate that develops_from a future spinal cord." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "neural plate of spinal cord" EXACT [OBOL:automatic] xref: FMA:312957 xref: TAO:0007021 xref: VHOG:0000439 xref: ZFA:0007021 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: develops_from UBERON:0006241 ! future spinal cord relationship: develops_from UBERON:0006241 {source="ZFA"} ! future spinal cord property_value: UBPROP:0000001 "Neural plate that is part of the spinal cord. [Bgee_curator][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000439", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000439", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003855 name: gonad mesenchyme namespace: uberon def: "Mesenchyme that is part of a developing gonad [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "gonada mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of gonad" EXACT [OBOL:automatic] synonym: "mesenchyme of gonada" EXACT [OBOL:automatic] xref: EHDAA:5012 xref: EMAPA:16858 xref: EMAPA:17385 xref: VHOG:0001090 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000991 ! gonad relationship: part_of UBERON:0000991 ! gonad [Term] id: UBERON:0003869 name: presumptive ganglion namespace: uberon def: "A presumptive structure that has the potential to develop into a ganglion." [OBOL:automatic] subset: human_subset subset: mouse_subset is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: has_potential_to_develop_into UBERON:0000045 ! ganglion relationship: has_potential_to_develop_into UBERON:0000045 ! ganglion [Term] id: UBERON:0003886 name: future coelemic cavity lumen namespace: uberon def: "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." [OBOL:automatic] subset: grouping_class subset: human_subset subset: mouse_subset subset: non_informative synonym: "body cavity precursor" RELATED [] synonym: "future coelomic cavity lumen" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: has_potential_to_develop_into UBERON:0002323 ! coelemic cavity lumen relationship: existence_ends_during UBERON:0000111 ! organogenesis stage relationship: existence_starts_during UBERON:0000109 ! gastrula stage relationship: has_potential_to_develop_into UBERON:0002323 ! coelemic cavity lumen relationship: part_of UBERON:0000926 ! mesoderm [Term] id: UBERON:0003887 name: intraembryonic coelom namespace: uberon def: "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." [MGI:anna, MP:0012187] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "somatic coelom" EXACT [Wikipedia:Intraembryonic_coelom] xref: EHDAA:251 xref: EMAPA:16088 xref: NCIT:C34195 xref: UMLS:C1512940 {source="ncithesaurus:Intraembryonic_Coelom"} xref: VHOG:0000316 xref: Wikipedia:Intraembryonic_coelom is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0003081 {source="Wikipedia"} ! lateral plate mesoderm relationship: part_of UBERON:0011997 ! coelom property_value: editor_note "consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults" xsd:string property_value: UBPROP:0000003 "(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000316", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.166", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003891 name: stroma namespace: uberon def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset synonym: "stromal connective tissue" RELATED [] xref: FMA:81494 xref: NCIT:C67387 xref: UMLS:C0927195 {source="ncithesaurus:Stroma_Connective_Tissue"} is_a: UBERON:0000064 ! organ part relationship: composed_primarily_of UBERON:0002384 ! connective tissue relationship: in_taxon NCBITaxon:6072 ! Eumetazoa property_value: UBPROP:0000007 "stromal" xsd:string [Term] id: UBERON:0003894 name: liver primordium namespace: uberon def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." [ISBN:3211492755] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "embryological hepatic plate" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "hepatic plate" RELATED [EHDAA2:0000744] synonym: "liver bud" RELATED INCONSISTENT [XAO:0003266, ZFA:0000124] synonym: "liver endoderm" RELATED [EFO:0002577] synonym: "primordium of the liver" EXACT [ncithesaurus:Primordium_of_the_Liver] xref: AAO:0011058 xref: BTO:0003391 xref: EFO:0002577 xref: EFO:0003428 xref: EHDAA2:0000744 xref: EHDAA:973 xref: EMAPA:16847 xref: NCIT:C34277 xref: TAO:0000124 xref: UMLS:C0734013 {source="ncithesaurus:Hepatic_Cord"} xref: UMLS:C1514451 {source="ncithesaurus:Primordium_of_the_Liver"} xref: XAO:0003266 xref: ZFA:0000124 is_a: UBERON:0000485 {source="EHDAA2"} ! simple columnar epithelium is_a: UBERON:0001048 {source="XAO"} ! primordium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0009497 ! epithelium of foregut-midgut junction intersection_of: UBERON:0001048 ! primordium intersection_of: has_potential_to_develop_into UBERON:0002107 ! liver relationship: develops_from UBERON:0001041 {notes="ventral foregut endoderm", source="Zaret 1996"} ! foregut relationship: has_potential_to_develop_into UBERON:0002107 ! liver relationship: part_of UBERON:0009550 {source="EHDAA2"} ! endoderm of foregut-midgut junction property_value: editor_note "consider adding further subdivisions of the endoderm, e.g. ventral foregut. Note we place two EFO classes here, it's not clear how they differ" xsd:string [Term] id: UBERON:0003897 name: axial muscle namespace: uberon def: "One of the skeletal muscles of the head and neck, spine, and ribs." [HP:0003327] subset: human_subset subset: mouse_subset subset: pheno_slim xref: EHDAA:5982 xref: EMAPA:18167 xref: MA:0003153 xref: RETIRED_EHDAA2:0000160 xref: TAO:0001954 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: attaches_to_part_of UBERON:0005944 ! axial skeleton plus cranial skeleton intersection_of: part_of UBERON:0013701 ! main body axis relationship: attaches_to_part_of UBERON:0005944 ! axial skeleton plus cranial skeleton relationship: part_of UBERON:0013700 ! axial musculature [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk namespace: uberon def: "A portion of skeletal muscle tissue in the trunk." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "skeletal muscle of torso" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of torso" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of trunk" EXACT [OBOL:automatic] synonym: "torso skeletal muscle" EXACT [OBOL:automatic] synonym: "torso skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "trunk skeletal muscle" EXACT [OBOL:automatic] synonym: "trunk skeletal muscle tissue" EXACT [OBOL:automatic] xref: SCTID:244848007 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0004479 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! musculature of trunk relationship: part_of UBERON:0013700 ! axial musculature [Term] id: UBERON:0003902 name: retinal neural layer namespace: uberon def: "The part of the retina that contains neurons and photoreceptor cells[GO]." [GO:0003407] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "neural layer of retina" EXACT [FMA:58628] synonym: "neural retina" EXACT [XAO:0003216, ZFA:0000046] synonym: "neural retinal epithelium" RELATED [MA:000027] synonym: "neuroretina" EXACT [ZFA:0000046] synonym: "stratum nervosum (retina)" EXACT [FMA:58628] synonym: "stratum nervosum retinae" EXACT OMO:0003011 [FMA:58628, FMA:TA] xref: AAO:0011095 xref: BTO:0000929 xref: CALOHA:TS-0685 xref: EHDAA2:0001253 xref: EHDAA:4763 xref: EMAPA:17171 xref: EMAPA:18590 xref: FMA:58628 xref: MA:0000277 xref: NCIT:C33166 xref: TAO:0000046 xref: UMLS:C1518263 {source="ncithesaurus:Neural_Retina"} xref: VHOG:0000535 xref: XAO:0003216 xref: ZFA:0000046 is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001781 ! layer of retina intersection_of: immediate_transformation_of UBERON:0005425 ! presumptive neural retina relationship: developmentally_induced_by UBERON:0005426 ! lens vesicle relationship: develops_from NCBITaxon:6072 ! Eumetazoa relationship: develops_from UBERON:0003072 ! optic cup relationship: develops_from UBERON:0005425 ! presumptive neural retina relationship: develops_from UBERON:0010312 ! immature eye relationship: has_part CL:0000210 ! photoreceptor cell relationship: immediate_transformation_of UBERON:0005425 {source="Bgee:AN"} ! presumptive neural retina property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000535", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003909 name: sinusoid namespace: uberon def: "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." [Wikipedia:Sinusoid_(blood_vessel)] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "endothelium of irregular blood filled space" RELATED [] synonym: "sinusoidal blood vessel" EXACT [] synonym: "sinusoidal blood vessel endothelium" EXACT [ZFA:0005261] synonym: "sinusoidal capillary" RELATED [http://www.medilexicon.com/medicaldictionary.php?t=13986] synonym: "sinusoidal endothelium" RELATED [] xref: FMA:63131 xref: SCTID:340163004 xref: TAO:0005261 xref: Wikipedia:Sinusoid_(blood_vessel) xref: ZFA:0005261 is_a: UBERON:2005260 {source="Wikipedia", source="ZFA"} ! fenestrated capillary property_value: UBPROP:0000001 "Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005261", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000007 "sinusoidal" xsd:string property_value: UBPROP:0000012 "some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined)." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0003914 name: epithelial tube namespace: uberon def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GO:0060562, PMID:12526790] subset: human_subset subset: mouse_subset synonym: "epithelial or endothelial tube" EXACT [] xref: AEO:0000114 xref: EHDAA2:0003114 xref: FBbt:00007474 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: has_quality PATO:0002299 ! tubular property_value: IAO:0000232 "contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers" xsd:string [Term] id: UBERON:0003915 name: endothelial tube namespace: uberon def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0001986 ! endothelium intersection_of: has_quality PATO:0002299 ! tubular [Term] id: UBERON:0003920 name: venous blood vessel namespace: uberon def: "A blood vessel that carries blood from the capillaries toward the heart." [http://www.thefreedictionary.com/venous+blood+vessel] comment: Compare to: vein subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "segment of venous tree organ" EXACT [FMA:86188] synonym: "venous tree organ segment" EXACT [FMA:86188] xref: EMAPA:35932 xref: FMA:86188 xref: MA:0000066 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0004582 ! venous system relationship: part_of UBERON:0004582 ! venous system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003921 name: pancreas primordium namespace: uberon def: "Embryonic structure that develops into pancreatic bud." [Wikipedia:Pancreas#Embryological_development] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "pancreatic anlage" RELATED [ZFA:0000254] synonym: "pancreatic endoderm" RELATED [EFO:0002579] synonym: "pancreatic primordium" EXACT [] synonym: "primordial pancreas" RELATED [FMA:79792] xref: EFO:0002579 xref: EFO:0003434 xref: EHDAA2:0001382 xref: EHDAA:2163 xref: EMAPA:17066 xref: FMA:79792 xref: TAO:0000254 xref: XAO:0001101 xref: ZFA:0000254 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: has_potential_to_develop_into UBERON:0001264 ! pancreas relationship: develops_from UBERON:0000925 {source="Wikipedia"} ! endoderm relationship: has_potential_to_develop_into UBERON:0001264 ! pancreas relationship: part_of UBERON:0007026 ! presumptive gut property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI property_value: UBPROP:0000012 "in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds" xsd:string {external_ontology="EHDAA2"} property_value: UBPROP:0000013 "revisit after standardizing terms 'primordium', 'anlagen', 'bud'" xsd:string [Term] id: UBERON:0003922 name: pancreatic epithelial bud namespace: uberon def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." [PMID:16417468, Wikipedia:Pancreatic_bud] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "pancreas epithelium" RELATED [EMAPA:35645] synonym: "pancreatic anlage" RELATED [] synonym: "pancreatic bud" EXACT [ZFA:0001390] synonym: "pancreatic buds" EXACT OMO:0003004 [TAO:0001390] xref: EFO:0003470 xref: EMAPA:35645 xref: NCIT:C34242 xref: SCTID:360398004 xref: TAO:0001390 xref: UMLS:C1283285 {source="ncithesaurus:Pancreatic_Bud"} xref: Wikipedia:Pancreatic_bud xref: ZFA:0001390 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac relationship: develops_from UBERON:0001041 {source="Wikipedia:Pancreas#Embryological_development"} ! foregut relationship: develops_from UBERON:0001555 ! digestive tract relationship: develops_from UBERON:0002114 {exception="zebrafish", source="Wikipedia:Pancreatic_bud"} ! duodenum relationship: develops_from UBERON:0009497 {source="EHDAA2-inferred"} ! epithelium of foregut-midgut junction relationship: part_of UBERON:0003921 {source="EHDAA2"} ! pancreas primordium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI [Term] id: UBERON:0003923 name: dorsal pancreatic bud namespace: uberon def: "Pancreatic bud that gives rise to the accessory pancreatic duct." [Wikipedia:Pancreatic_bud] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "dorsal pancreas anlage" RELATED [] synonym: "dorsal pancreatic anlage" RELATED [] synonym: "pancreas dorsal primordium duct bud" EXACT [EHDAA2:0001385] synonym: "pancreas primordium dorsal bud" EXACT [] synonym: "posterior pancreatic anlage" RELATED [] synonym: "posterior pancreatic bud" RELATED [] synonym: "primary pancreatic bud" EXACT [XAO:0000467] xref: AAO:0011031 xref: EFO:0003465 xref: EHDAA2:0001385 xref: EMAPA:17067 xref: SCTID:361435005 xref: TAO:0001370 xref: VHOG:0001428 xref: Wikipedia:Pancreatic_bud xref: XAO:0000467 xref: ZFA:0001370 is_a: UBERON:0003922 ! pancreatic epithelial bud relationship: developmentally_induced_by UBERON:0002328 {gci_relation="part_of", gci_filler="NCBITaxon:10088", source="PMID:16417468"} ! notochord relationship: developmentally_induced_by UBERON:0005805 {gci_relation="part_of", gci_filler="NCBITaxon:10088", source="PMID:16417468"} ! dorsal aorta relationship: develops_from UBERON:0001045 {source="XAO"} ! midgut relationship: part_of UBERON:0010375 {source="EHDAA2"} ! pancreas dorsal primordium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI property_value: UBPROP:0000001 "The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011031", ontology="AAO", source="XAO:curator"} property_value: UBPROP:0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001428", ontology="VHOG", source="DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003924 name: ventral pancreatic bud namespace: uberon def: "Pancreatic bud that gives rise to the major pancreatic duct." [Wikipedia:Pancreatic_bud] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "anterior pancreatic anlage" RELATED [] synonym: "anterior pancreatic bud" RELATED [] synonym: "pancreas primordium ventral bud" EXACT [] synonym: "pancreas ventral primordium duct bud" EXACT [EHDAA2:0001389] synonym: "ventral pancreas anlage" RELATED [] synonym: "ventral pancreatic anlage" RELATED [] xref: AAO:0011111 xref: EFO:0003464 xref: EHDAA2:0001389 xref: EMAPA:17256 xref: SCTID:361437002 xref: TAO:0001369 xref: VHOG:0001429 xref: Wikipedia:Pancreatic_bud xref: XAO:0001103 xref: ZFA:0001369 is_a: UBERON:0003922 ! pancreatic epithelial bud relationship: develops_from UBERON:0008835 {source="PMID:16417468", source="WP"} ! hepatic diverticulum relationship: part_of UBERON:0010376 {source="EHDAA2"} ! pancreas ventral primordium property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI property_value: UBPROP:0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001429", ontology="VHOG", source="DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "the ventral pancreas and liver are derived from a common precursor cell population[PMID:16417468]. TODO - add this relationship." xsd:string property_value: UBPROP:0000011 "The ventral pancreatic bud becomes the head and uncinate process, and comes from the hepatic diverticulum[WP]" xsd:string [Term] id: UBERON:0003928 name: digestive system duct namespace: uberon def: "A duct that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "duct of digestive system" EXACT [OBOL:automatic] synonym: "duct of gastrointestinal system" EXACT [OBOL:automatic] synonym: "gastrointestinal system duct" EXACT [OBOL:automatic] xref: TAO:0005162 xref: ZFA:0005162 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0001007 ! digestive system [Term] id: UBERON:0003929 name: digestive tract epithelium namespace: uberon def: "An epithelium that lines the lumen of the digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset synonym: "alimentary tract epithelium" RELATED [OBOL:automatic] synonym: "digestive tract epithelial tissue" EXACT [OBOL:automatic] synonym: "epithelial tissue of digestive tract" EXACT [OBOL:automatic] synonym: "epithelial tissue of gut" EXACT [OBOL:automatic] synonym: "epithelium of digestive tract" EXACT [OBOL:automatic] synonym: "epithelium of gut" EXACT [OBOL:automatic] synonym: "gastrodermis" EXACT SENSU [https://orcid.org/0000-0003-3308-6245, NCBITaxon:6073] synonym: "gut epithelial tissue" EXACT [OBOL:automatic] synonym: "gut epithelium" EXACT [EHDAA2:0004567, MA:0003201, ZFA:0005123] xref: BTO:0000956 xref: EHDAA2:0004567 xref: EMAPA:32928 xref: FBbt:00047166 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MA:0003201 xref: NCIT:C12963 xref: TAO:0005123 xref: UMLS:C0836205 {source="ncithesaurus:Gut_Epithelium"} xref: XAO:0003200 xref: ZFA:0005123 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: UBPROP:0000001 "Epithelium lining the lumen of the gut.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005123", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "" xsd:string [Term] id: UBERON:0003932 name: cartilage element of chondrocranium namespace: uberon def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_subset subset: mouse_subset synonym: "cartilage of chondrocranium" EXACT [OBOL:accepted] synonym: "cartilaginous element of chondrocranium" EXACT [OBOL:accepted] synonym: "chondrocranium cartilage" EXACT [ZFA:0001461] synonym: "neurocranium cartilage" EXACT [ZFA:0001461] xref: EFO:0003690 xref: TAO:0001461 xref: ZFA:0001461 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0002241 ! chondrocranium relationship: part_of UBERON:0002241 ! chondrocranium [Term] id: UBERON:0003933 name: cranial cartilage namespace: uberon def: "A cartilage element that is part of the cranial skeleton." [https://orcid.org/0000-0002-6601-2165, ZFA:0001458] subset: human_subset subset: mouse_subset synonym: "cartilage of cranium" EXACT [OBOL:automatic] synonym: "cranial cartilages" RELATED OMO:0003004 [ZFA:0001458] synonym: "cranium cartilage" EXACT [OBOL:automatic] xref: TAO:0001458 xref: ZFA:0001458 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0010323 ! cranial skeletal system relationship: part_of UBERON:0010323 ! cranial skeletal system property_value: UBPROP:0000001 "Cartilage which is part of the cranium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001458", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0003937 name: reproductive gland namespace: uberon def: "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." [MP:0000653] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "genitalia gland" EXACT [OBOL:automatic] synonym: "gland of genitalia" EXACT [MP:0000653] synonym: "gland of reproductive system" EXACT [OBOL:automatic] synonym: "reproductive gland" EXACT [MA:0001751] synonym: "reproductive system gland" EXACT [OBOL:automatic] synonym: "sex gland" EXACT [MP:0000653] xref: BTO:0006162 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: MA:0001751 is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0003942 name: somatosensory system namespace: uberon alt_id: UBERON:0014511 def: "The sensory system for the sense of touch and pain." [NLXANAT:090818] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "somatic sensory system" EXACT [] synonym: "system for detection of somatic senses" EXACT [] xref: EMAPA:37954 {source="MA:th"} xref: neuronames:2887 xref: NLXANAT:090818 xref: Wikipedia:Somatosensory_system is_a: UBERON:0001032 ! sensory system relationship: capable_of_part_of GO:0019233 ! sensory perception of pain relationship: capable_of_part_of GO:0050975 ! sensory perception of touch property_value: UBPROP:0000001 "The neural tissue involved in the transmission of sensory signals" xsd:string {source="MP:0000959"} property_value: UBPROP:0000012 "MP defines this in a may more appropriate to somatosensory cortex" xsd:string {external_ontology="MP"} [Term] id: UBERON:0003952 name: anterior stroma of cornea namespace: uberon def: "The anterior segment of the lamellated connective tissue layer of the cornea." [MP:0003093] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "anterior stroma" BROAD [MP:0003093] synonym: "cornea anterior stroma" EXACT [MP:0003093] xref: EMAPA:37414 {source="MA:th"} is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: in_anterior_side_of UBERON:0001777 ! substantia propria of cornea disjoint_from: UBERON:0003953 {source="lexical"} ! posterior stroma of cornea relationship: contributes_to_morphology_of UBERON:0001777 ! substantia propria of cornea relationship: in_anterior_side_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003953 name: posterior stroma of cornea namespace: uberon def: "The posterior segment of the lamellated connective tissue layer of the cornea." [MP:0003094] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cornea posterior stroma" EXACT [MP:0003094] synonym: "posterior stroma" BROAD [MP:0003094] xref: EMAPA:37415 {source="MA:th"} is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: in_posterior_side_of UBERON:0001777 ! substantia propria of cornea relationship: contributes_to_morphology_of UBERON:0001777 ! substantia propria of cornea relationship: in_posterior_side_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea [Term] id: UBERON:0003967 name: cutaneous elastic tissue namespace: uberon def: "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." [MP:0008418] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cutaneous elastic fiber" NARROW [MP:0008418] synonym: "dermal elastic fiber" NARROW [MP:0008418] xref: EMAPA:37841 {source="MA:th"} is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0000014 ! zone of skin relationship: contributes_to_morphology_of UBERON:0000014 ! zone of skin relationship: part_of UBERON:0000014 ! zone of skin [Term] id: UBERON:0003975 name: internal female genitalia namespace: uberon def: "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." [MP:0009209] comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "female internal genitalia" EXACT [FMA:45654] synonym: "internal female genital organ" EXACT [BTO:0003099] synonym: "internal genitalia of female reproductive system" EXACT [OBOL:automatic] synonym: "organa genitalia feminina interna" RELATED [BTO:0003099] xref: BTO:0003099 xref: FMA:45654 xref: SCTID:303518005 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: part_of UBERON:0000474 ! female reproductive system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004015 name: embryonic-extraembryonic boundary namespace: uberon def: "The connection between the embryo proper and extraembryonic tissues." [MP:0003890] subset: human_subset subset: mouse_subset subset: pheno_slim is_a: UBERON:0000015 ! non-material anatomical boundary intersection_of: UBERON:0000015 ! non-material anatomical boundary intersection_of: adjacent_to UBERON:0000478 ! extraembryonic structure intersection_of: adjacent_to UBERON:0002050 ! embryonic structure relationship: adjacent_to UBERON:0000478 ! extraembryonic structure relationship: adjacent_to UBERON:0002050 ! embryonic structure [Term] id: UBERON:0004016 name: dermatome namespace: uberon def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:0001017, AEO:JB] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cutis plate" EXACT [Wikipedia:Cutis_plate] synonym: "dermatomal mesenchyme" EXACT [Wikipedia:Cutis_plate] synonym: "epimere mesoderm" RELATED [] synonym: "mesenchyma dermatomiale" RELATED OMO:0003011 [Wikipedia:Dermatomal_mesenchyme] xref: AAO:0011028 xref: AEO:0001017 xref: BTO:0006248 {https://w3id.org/sssom/mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration", https://w3id.org/sssom/author_id="https://orcid.org/0000-0003-4423-4370", https://w3id.org/sssom/mapping_provider="https://github.com/biopragmatics/biomappings"} xref: EHDAA2_RETIRED:0003428 xref: EHDAA:1719 xref: EHDAA:1725 xref: EHDAA:1731 xref: EHDAA:1737 xref: EMAPA:32838 xref: FMA:295656 xref: NCIT:C61572 xref: UMLS:C0180383 {source="ncithesaurus:Dermatome"} xref: Wikipedia:Dermatome_(embryology) xref: XAO:0000220 is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png xsd:anyURI property_value: UBPROP:0000013 "Not to be confused with 'dermatome segment of skin'." xsd:string [Term] id: UBERON:0004022 name: germinal neuroepithelium namespace: uberon def: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0004261] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "germinal neuroepithelial layer" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "germinal neuroepithelium" EXACT [NCBIBook:NBK10047] synonym: "original neural tube" EXACT [NCBIBook:NBK10047] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0034706 {source="NCBIBook:NBK10047"} ! proliferating neuroepithelium disjoint_from: UBERON:0006934 ! sensory epithelium relationship: adjacent_to UBERON:0003842 ! neural tube lumen relationship: bounding_layer_of UBERON:0001049 ! neural tube relationship: part_of UBERON:0001049 ! neural tube property_value: UBPROP:0000011 "As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047]" xsd:string [Term] id: UBERON:0004058 name: biliary ductule namespace: uberon def: "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." [BTO:0002840, MP:0009494] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bile capillary" RELATED [BTO:0002840] synonym: "bile ductule" EXACT [BTO:0002840] synonym: "biliary ductule" EXACT [http://www.mondofacto.com/facts/dictionary?ductuli+biliferi] synonym: "biliary ductule" RELATED [BTO:0002840] synonym: "cholangiole" RELATED [BTO:0002840] synonym: "ductuli biliferi" EXACT [http://www.mondofacto.com/facts/dictionary?ductuli+biliferi] synonym: "terminal cholangiole" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0002840 xref: EMAPA:37440 {source="MA:th"} xref: TAO:0005164 xref: ZFA:0005164 is_a: UBERON:0000025 ! tube relationship: adjacent_to UBERON:0001175 ! common hepatic duct relationship: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002394 {source="BTO"} ! bile duct property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "In ZFA, Digestive system duct that collects bile from the canaliculus and transports bile through the liver -- (check if the same) // The smallest and the most peripheral branches of the biliary tree consist of a portal part (portal ductule) and an intralobular part (intralobular ductule)" xsd:string {external_ontology="ZFA"} [Term] id: UBERON:0004060 name: neural tube ventricular layer namespace: uberon def: "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009689] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "ependymal layer" BROAD [NCBIBook:NBK10047] synonym: "neural tube ependymal layer" EXACT [NCBIBook:NBK10047] synonym: "neural tube ependymal zone" NARROW [MP:0009689] synonym: "neural tube ventricular germinal zone" EXACT [NCBIBook:NBK10047] synonym: "neural tube ventricular zone" EXACT [MP:0009689] xref: EMAPA:17152 xref: EMAPA:35362 xref: EMAPA_RETIRED:16783 xref: MA:0003193 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 {source="NCBIBook:NBK10047"} ! proliferating neuroepithelium relationship: adjacent_to UBERON:0003842 ! neural tube lumen relationship: develops_from UBERON:0001016 ! nervous system relationship: develops_from UBERON:0001049 ! neural tube relationship: develops_from UBERON:0004022 ! germinal neuroepithelium relationship: immediate_transformation_of UBERON:0004022 {source="NCBIBook:NBK10047"} ! germinal neuroepithelium relationship: part_of UBERON:0001049 ! neural tube property_value: editor_note "consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure" xsd:string property_value: UBPROP:0000001 "The layer of undifferentiated, proliferating cells that line the neural tube lumen" xsd:string {source="MP:0009689"} [Term] id: UBERON:0004061 name: neural tube mantle layer namespace: uberon def: "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "future brain marginal layer" RELATED [EMAPA:35360] synonym: "neural tube intermediate zone" EXACT [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] xref: EMAPA:17148 xref: EMAPA:35360 xref: neuronames:1367 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0034707 {source="NCBIBook:NBK10047"} ! differentiating neuroepithelium relationship: adjacent_to UBERON:0004060 ! neural tube ventricular layer relationship: adjacent_to UBERON:0004062 ! neural tube marginal layer relationship: develops_from UBERON:0004022 {notes="by division", source="NCBIBook:NBK10047"} ! germinal neuroepithelium relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0004062 name: neural tube marginal layer namespace: uberon def: "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009691] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "brain marginal zone" RELATED [] synonym: "neural tube marginal zone" EXACT [MP:0009691] xref: EMAPA:17151 xref: neuronames:1368 is_a: UBERON:0005162 ! multi cell part structure relationship: adjacent_to UBERON:0004061 ! neural tube mantle layer relationship: develops_from UBERON:0004061 {notes="forms from axons"} ! neural tube mantle layer relationship: part_of UBERON:0001049 ! neural tube [Term] id: UBERON:0004064 name: neural tube basal plate namespace: uberon def: "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009693, Wikipedia:Basal_plate_(neural_tube)] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "basal plate" EXACT [] synonym: "basal plate of neural tube" EXACT [Wikipedia:Basal_plate_(neural_tube)] synonym: "motor part of neural tube" RELATED [] synonym: "spinal cord basal plate" NARROW [MP:0009693] synonym: "ventral part of neural tube" RELATED [] xref: AAO:0010561 xref: EFO:0001904 xref: NCIT:C34111 xref: neuronames:1372 xref: UMLS:C1511061 {source="ncithesaurus:Basal_Plate"} xref: Wikipedia:Basal_plate_(neural_tube) is_a: UBERON:0005291 ! embryonic tissue relationship: contributes_to_morphology_of UBERON:0004061 ! neural tube mantle layer relationship: developmentally_induced_by UBERON:0002328 {gene="Shh", source="Swenson"} ! notochord relationship: has_part CL:0000100 ! motor neuron relationship: part_of UBERON:0004061 ! neural tube mantle layer relationship: ventral_to UBERON:0005478 ! sulcus limitans of neural tube [Term] id: UBERON:0004066 name: frontonasal prominence namespace: uberon alt_id: UBERON:0006237 def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." [MP:0009901] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "embryonic frontonasal prominence" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "forebrain prominence" RELATED [MP:0009901] synonym: "frontonasal mass" RELATED [MP:0009901] synonym: "frontonasal process" RELATED [MP:0009901] synonym: "prominentia frontonasalis" RELATED OMO:0003011 [Wikipedia:Frontonasal_prominence] xref: EHDAA2:0000578 xref: EHDAA:4778 xref: EMAPA:16681 xref: FMA:293101 xref: NCIT:C34182 xref: SCTID:361486000 xref: UMLS:C1517321 {source="ncithesaurus:Frontonasal_Prominence"} xref: VHOG:0001319 xref: Wikipedia:Frontonasal_prominence is_a: UBERON:0009292 ! embryonic nasal process relationship: intersects_midsagittal_plane_of UBERON:0000033 ! head property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png xsd:anyURI [Term] id: UBERON:0004068 name: medial nasal prominence namespace: uberon def: "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." [MP:0009903, Wikipedia:Medial_nasal_prominence] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "medial nasal process" EXACT [EHDAA2:0001076] synonym: "medial nasal swelling" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "medial-nasal process" EXACT [EMAPA:16808] synonym: "nasomedial prominence" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "prominentia nasalis medialis" EXACT OMO:0003011 [Wikipedia:Medial_nasal_prominence] xref: EHDAA2:0001076 xref: EHDAA:4792 xref: EMAPA:16808 xref: FMA:295858 xref: SCTID:308877001 xref: VHOG:0000804 xref: Wikipedia:Medial_nasal_prominence is_a: UBERON:0009292 ! embryonic nasal process relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence relationship: in_lateral_side_of UBERON:0008816 ! embryonic head relationship: part_of UBERON:0004066 {source="EHDAA2"} ! frontonasal prominence relationship: part_of UBERON:0008816 ! embryonic head property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png xsd:anyURI property_value: UBPROP:0000011 "Fusion of right and left medial nasal processes forms a primary palate rostrally and the nasal septum caudally. The incisive bone, including upper incisor teeth and the rostral up- per lip, are derived from the primary palate. The nasal septum consists of bone, cartilage, and a patch of soft tissue membrane that separates right & left halves of the nasal cavity." xsd:string [Term] id: UBERON:0004087 name: vena cava namespace: uberon def: "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Venae_cavae] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "caval vein" RELATED [] synonym: "venae cavae" RELATED OMO:0003004 [Wikipedia:Venae_cavae] xref: AAO:0010215 xref: BTO:0001438 xref: EMAPA:18415 xref: FMA:321896 xref: GAID:547 xref: MA:0000068 xref: MESH:D014684 xref: NCIT:C12817 xref: SCTID:244405007 xref: UMLS:C0042460 {source="ncithesaurus:Vena_Cava"} xref: Wikipedia:Venae_cavae is_a: UBERON:0003479 ! thoracic cavity vein is_a: UBERON:0013768 ! great vessel of heart property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png xsd:anyURI [Term] id: UBERON:0004088 name: orbital region namespace: uberon def: "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "content of orbital part of eye" EXACT [FMA:260119] synonym: "eye region" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ocular and peri-ocular region" RELATED [] synonym: "ocular region" RELATED [] synonym: "orbital content" RELATED [FMA:260119] synonym: "orbital part of eye" RELATED [FMA:72951] synonym: "orbital part of face" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:260119 is_a: UBERON:0001444 ! subdivision of head relationship: part_of UBERON:0001456 ! face property_value: editor_note "note the FMA class is more narrow though, and is more like eye + muscles + vasculature. The FMA also has FMA:72951 orbital part of eye" xsd:string property_value: UBPROP:0000012 "in HP covers eyelid, eyebrow." xsd:string {external_ontology="HP:0000284"} [Term] id: UBERON:0004089 name: midface namespace: uberon def: "The middle of the face including the nose and its associated bony structures[MW]." [HP:0000309, http://www.merriam-webster.com/medical/midface] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "lower face" RELATED [] synonym: "midface/lower face" RELATED [] synonym: "snout" RELATED SENSU [MA:0001910] xref: FMA:285406 xref: MA:0001910 is_a: UBERON:0001444 ! subdivision of head relationship: contributes_to_morphology_of UBERON:0001456 ! face relationship: in_taxon NCBITaxon:89593 ! Craniata relationship: part_of UBERON:0001456 ! face property_value: editor_note "this class is currently a union of the snout (e.g. in mouse), the midface and the lower face. Note that in MA, snout includes the whole jaw and should thus be more alike the lower face than the midface, so its placement here is not strictly accurate. In future we might introduce specific classes for each of these, and include the full parthood relationships. if this is done, then care should be taken to preserve inferences such as an abnormality of the lower face being an abnormality of the midface." xsd:string property_value: UBPROP:0000007 "midfacial" xsd:string [Term] id: UBERON:0004111 name: anatomical conduit namespace: uberon def: "Any tube, opening or passage that connects two distinct anatomical spaces." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: human_subset subset: mouse_subset synonym: "foramen" NARROW [EHDAA2:0003080] synonym: "foramina" NARROW OMO:0003004 [https://orcid.org/0000-0002-6601-2165] synonym: "opening" RELATED [] synonym: "ostia" RELATED OMO:0003004 [] synonym: "ostium" RELATED [] xref: AEO:0000080 xref: EHDAA2:0003080 xref: FMA:242873 xref: SCTID:346902003 xref: Wikipedia:Foramen is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: conduit_for UBERON:0000061 ! anatomical structure intersection_of: has_part UBERON:0013686 ! anatomical conduit space relationship: conduit_for UBERON:0000061 ! anatomical structure relationship: connects UBERON:0000464 {cardinality="2"} ! anatomical space relationship: has_part UBERON:0013686 ! anatomical conduit space property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000012 "FMA has both conduit and conduit space. In EHDAA2 this is a surface feature" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0004118 name: vasculature of iris namespace: uberon def: "A vasculature that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "iris blood vessels" EXACT [ZFA:0005568] synonym: "iris vascular network" EXACT [OBOL:automatic] synonym: "iris vasculature" EXACT [] synonym: "vascular network of iris" EXACT [OBOL:automatic] xref: ZFA:0005568 is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris [Term] id: UBERON:0004119 name: endoderm-derived structure namespace: uberon def: "An anatomical structure that develops (entirely or partially) from the endoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000925 ! endoderm relationship: develops_from UBERON:0000925 ! endoderm property_value: IAO:0000232 "Grouping term for query purposes" xsd:string [Term] id: UBERON:0004120 name: mesoderm-derived structure namespace: uberon def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset synonym: "mesodermal derivative" EXACT [FBbt:00025998] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000926 ! mesoderm relationship: develops_from UBERON:0000926 ! mesoderm property_value: IAO:0000232 "Grouping term for query purposes" xsd:string [Term] id: UBERON:0004121 name: ectoderm-derived structure namespace: uberon def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset synonym: "ectodermal deriviative" EXACT [FBbt:00025990] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: develops_from UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0000924 ! ectoderm property_value: IAO:0000232 "Grouping term for query purposes" xsd:string [Term] id: UBERON:0004122 name: genitourinary system namespace: uberon def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." [VHOG:0000286] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "genito-urinary system" RELATED [FMA:280610] synonym: "genitourinary tract" RELATED [] synonym: "GU tract" RELATED [] synonym: "UG tract" RELATED [] synonym: "urogenital system" EXACT [] synonym: "urogenital tract" RELATED [BTO:0003091] synonym: "Urogenitalsystem" RELATED [BTO:0003091] xref: AAO:0000624 xref: BILA:0000122 xref: BTO:0003091 xref: EFO:0003864 xref: EHDAA:1013 xref: EMAPA:16367 xref: EV:0100094 xref: FMA:280610 xref: GAID:362 xref: galen:GenitoUrinarySystem xref: MESH:D014566 xref: NCIT:C12810 xref: SCTID:278861008 xref: UMLS:C0042066 {source="ncithesaurus:Genitourinary_System"} xref: VHOG:0000286 xref: XAO:0000140 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: has_part UBERON:0000990 ! reproductive system intersection_of: has_part UBERON:0001008 ! renal system relationship: develops_from UBERON:0003064 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="AAO", source="https://github.com/geneontology/go-ontology/issues/16143"} ! intermediate mesoderm relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0000990 ! reproductive system relationship: has_part UBERON:0001008 ! renal system property_value: UBPROP:0000001 "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000624", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000002 "relationship type change: differentiates_from intermediate mesoderm (AAO:0010575) CHANGED TO: develops_from intermediate mesoderm (UBERON:0003064)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000624", ontology="AAO"} property_value: UBPROP:0000003 "Kidneys and gonads (of vertebrates) develop from adjacent tissues, and after the excretory or urinary ducts have developed, the reproductive system usually taps into them or their derivatives.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000286", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.633", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "genitourinary" xsd:string property_value: UBPROP:0000007 "urogenital" xsd:string [Term] id: UBERON:0004123 name: myocardial layer namespace: uberon def: "Any of the layers of the myocardium. Example: compact layer, trabecular layer." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: non_informative subset: pheno_slim synonym: "layer of myocardium" EXACT [] synonym: "myocardium layer" EXACT [] xref: EMAPA:37475 {source="MA:th"} xref: MA:0000080 is_a: UBERON:0005983 ! heart layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: layer_part_of UBERON:0002349 ! myocardium relationship: layer_part_of UBERON:0002349 ! myocardium relationship: part_of UBERON:0002349 ! myocardium [Term] id: UBERON:0004124 name: myocardium trabecular layer namespace: uberon def: "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." [ZFA:0005059] subset: efo_slim subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "heart muscle trabecula" RELATED [] synonym: "heart muscle trabeculae" RELATED OMO:0003004 [] synonym: "myocardial trabeculae carneae" RELATED OMO:0003004 [] synonym: "myocardial trabecular layer" EXACT [] synonym: "trabecula of heart muscle" RELATED [] synonym: "trabeculae" RELATED [TAO:0005059] synonym: "trabecular layer" EXACT [ZFA:0005059] xref: EFO:0003706 xref: MA:0002866 xref: TAO:0005059 xref: ZFA:0005059 is_a: UBERON:0004123 ! myocardial layer intersection_of: UBERON:0004123 ! myocardial layer intersection_of: adjacent_to UBERON:0002165 ! endocardium intersection_of: composed_primarily_of GO:0036194 ! muscle cell projection relationship: adjacent_to UBERON:0002165 ! endocardium relationship: composed_primarily_of GO:0036194 ! muscle cell projection property_value: UBPROP:0000001 "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the the endocardium. Unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae of the zebrafish have more strut-like character, and are more uniform without apparent regional differences Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005059", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0004126 name: trabecular layer of ventricle namespace: uberon def: "A myocardium trabecular layer that is part of a cardiac ventricle." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: vertebrate_core synonym: "myocardium of region of ventricle" EXACT [FMA:83511] synonym: "trabecular cardiac ventricle muscle" EXACT [GO:0003222] synonym: "ventricular trabecular myocardium" EXACT [GO:0003222] xref: FMA:83511 xref: TAO:0005060 xref: ZFA:0005060 is_a: UBERON:0004124 ! myocardium trabecular layer intersection_of: UBERON:0004124 ! myocardium trabecular layer intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0001083 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! myocardium of ventricle property_value: editor_note "TODO - check FMA" xsd:string [Term] id: UBERON:0004128 name: optic vesicle namespace: uberon def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." [GO:0003404, Wikipedia:Optic_vesicles] comment: Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "evagination" RELATED [] synonym: "eye vesicle" RELATED [XAO:0000228] synonym: "ocular vesicle" RELATED [VHOG:0000165] synonym: "optic vesicles" RELATED OMO:0003004 [ZFA:0000050] xref: AAO:0011039 xref: EHDAA2:0001320 xref: EMAPA:16540 xref: FMA:293357 xref: NCIT:C34236 xref: SCTID:362864008 xref: TAO:0000050 xref: UMLS:C0231106 {source="ncithesaurus:Optic_Vesicle"} xref: VHOG:0000165 xref: Wikipedia:Optic_vesicles xref: XAO:0000228 xref: ZFA:0000050 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm relationship: develops_from UBERON:0002346 {source="GO-def"} ! neurectoderm relationship: develops_from UBERON:0003071 {source="ZFA"} ! eye primordium relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png xsd:anyURI property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} [Term] id: UBERON:0004133 name: salivatory nucleus namespace: uberon def: "Missing definition for term UBERON:0004133. Please replace it using linked reference." [GO:0021751] subset: human_subset subset: mouse_subset synonym: "salivary nucleus" EXACT [GO:0021751] is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: part_of UBERON:0000988 ! pons [Term] id: UBERON:0004139 name: cardiogenic plate namespace: uberon def: "The first recognizable structure derived from the heart field." [GO:0003142] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cardiac crescent" RELATED [EMAPA:16106] synonym: "cardiogenic crescent" RELATED [GO:0003142] synonym: "heart rudiment" RELATED [] synonym: "myocardial plate" EXACT [EHDAA2:0000215] xref: EHDAA2:0000215 xref: EMAPA:16106 xref: VHOG:0000975 is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0003084 ! heart primordium property_value: editor_note "TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO" xsd:string property_value: UBPROP:0000003 "(In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000975", ontology="VHOG", source="PMID:15611355 Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE, Basics of cardiac development for the understanding of congenital heart malformations. Pediatric Research (2005)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0004140 name: primary heart field namespace: uberon def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GO:0003138, GOC:mtg_heart, GOC:rl] subset: human_subset subset: mouse_subset synonym: "FHF" RELATED OMO:0003000 [XAO:0004185] synonym: "first heart field" EXACT [XAO:0004185] synonym: "heart field" RELATED [XAO:0004185] synonym: "PHF" RELATED OMO:0003000 [XAO:0004185] synonym: "primary heart field" EXACT [PMID:17276708, XAO:0004185] xref: XAO:0004185 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage relationship: part_of UBERON:0003081 {source="GO:0003128"} ! lateral plate mesoderm relationship: part_of UBERON:0036146 {source="https://orcid.org/0000-0003-3308-6245"} ! cardiopharyngeal field property_value: UBPROP:0000012 "this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]" xsd:string {external_ontology="GO"} [Term] id: UBERON:0004141 name: heart tube namespace: uberon def: "An epithelial tube that will give rise to the mature heart." [GO:0003143, GOC:mtg_heart] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: vertebrate_core synonym: "embryonic heart tube" EXACT [GO:0003143] synonym: "endocardial heart tube" EXACT [MP:0012700] synonym: "endocardial tube" EXACT [XAO:0000337] xref: AAO:0010411 xref: EFO:0003526 xref: EMAPA:32685 xref: NCIT:C34161 xref: TAO:0000360 xref: XAO:0000337 xref: ZFA:0000360 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from NCBITaxon:6072 ! Eumetazoa relationship: develops_from UBERON:0005498 ! primitive heart tube relationship: immediate_transformation_of UBERON:0005498 {source="ZFA-modified"} ! primitive heart tube property_value: UBPROP:0000001 "the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube." xsd:string {source="MP:0012700"} [Term] id: UBERON:0004142 name: outflow tract septum namespace: uberon def: "The outflow tract septum is a partition in the outflow tract." [GO:0003148] subset: human_subset subset: mouse_subset xref: XAO:0004141 is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004145 name: outflow tract namespace: uberon def: "The outflow tract is the portion of the heart through which blood flows into the arteries." [GO:0003151] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "arterial (outflow) pole" RELATED [PMID:20735616] synonym: "cardiac outflow tract" EXACT [PMID:20735616] synonym: "heart outflow tract" EXACT [] xref: EHDAA2:0001351 xref: EHDAA:464 xref: EHDAA:798 xref: EMAPA:16346 xref: MA:0000100 xref: VHOG:0000670 xref: XAO:0004139 is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0000178 ! blood relationship: channels_from UBERON:0000948 ! heart relationship: channels_into UBERON:0001637 ! artery relationship: part_of UBERON:0000948 ! heart property_value: UBPROP:0000008 "Depending on the species, attached at the cardiac outflow are described the conus arteriosus, the truncus arteriosus and, or the bulbus arteriosus. At the distal limit of these outflow structures, but lying outside the pericardial cavity, is the ventral aorta[PMID:20735616]" xsd:string [Term] id: UBERON:0004146 name: His-Purkinje system namespace: uberon def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GO:0003164, https://github.com/geneontology/go-ontology/issues/12451] subset: human_subset subset: mouse_subset synonym: "His-Purkinji network" EXACT [] synonym: "HPS" EXACT OMO:0003000 [] synonym: "VCS" EXACT [] synonym: "ventricular conduction system" EXACT [] is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: in_taxon NCBITaxon:32523 {source="PMID:12626327", source="PMID:21234997", source="github:michaelerice"} ! Tetrapoda relationship: part_of UBERON:0002350 {source="GO"} ! conducting system of heart property_value: UBPROP:0000001 "the intraventricular conduction system from the bundle of His to the distal Purkinje fibers, which carries the impulse to the ventricles." xsd:string {source="http://medical-dictionary.thefreedictionary.com/His-Purkinje+system"} [Term] id: UBERON:0004148 name: cardiac vein namespace: uberon def: "Vein of heart that drains the myocardium." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "cardiac vein" EXACT [FMA:12846] synonym: "coronary vein" EXACT [ZFA:0005814] synonym: "coronary vein" RELATED [Wikipedia:Coronary_circulation] synonym: "heart vein" EXACT [OBOL:automatic] synonym: "vein of heart" EXACT [OBOL:automatic] xref: EHDAA2:0004507 xref: EMAPA:37137 {source="MA:th"} xref: FMA:12846 xref: galen:CoronaryVein xref: NCIT:C12878 xref: NCIT:C12882 xref: SCTID:277726009 xref: UMLS:C0226654 {source="ncithesaurus:Cardiac_Vein"} xref: UMLS:C0226737 {source="ncithesaurus:Coronary_Vein"} xref: Wikipedia:Coronary_circulation xref: ZFA:0005814 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0005194 ! thoracic vein is_a: UBERON:0013140 {source="FMA"} ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000948 ! heart intersection_of: vessel_drains_blood_from UBERON:0002349 ! myocardium relationship: part_of RO:0002577 ! system relationship: vessel_drains_blood_from UBERON:0002349 ! myocardium property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb xsd:anyURI property_value: http://xmlns.com/foaf/0.1/depiction https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb xsd:anyURI [Term] id: UBERON:0004151 name: cardiac chamber namespace: uberon def: "A cardiac chamber surrounds an enclosed cavity within the heart." [GO:0003205] comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus subset: human_subset subset: mouse_subset synonym: "chamber of heart" EXACT [] synonym: "heart chamber" EXACT [] xref: FMA:7095 xref: SCTID:276456008 is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0000948 ! heart [Term] id: UBERON:0004160 name: proepicardium namespace: uberon def: "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." [GO:0003342, http://en.wiktionary.org/wiki/proepicardium] subset: human_subset subset: mouse_subset synonym: "proepicardial cluster" EXACT [ZFA:0005808] synonym: "proepicardial organ" EXACT [ZFIN:ZDB-PUB-080218-16] xref: EMAPA:36025 xref: ZFA:0005808 is_a: UBERON:0003104 ! mesenchyme relationship: part_of UBERON:0004161 {notes="todo check other taxa"} ! septum transversum relationship: part_of UBERON:0004535 {source="ZFA"} ! cardiovascular system property_value: UBPROP:0000007 "propepicardial" xsd:string property_value: UBPROP:0000008 "Proepicardial clusters in Zebrafish form on the pericardial wall, adjacent to the atrioventricular (AV) junction and near the venous pole[ZFA]" xsd:string [Term] id: UBERON:0004161 name: septum transversum namespace: uberon def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." [VHOG:0000019, Wikipedia:Septum_transversum] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "transverse septum" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0001829 xref: EHDAA:736 xref: EMAPA:16318 xref: FMA:295593 xref: NCIT:C34296 xref: SCTID:308819008 xref: UMLS:C0231004 {source="ncithesaurus:Septum_Transversum"} xref: VHOG:0000019 xref: Wikipedia:Septum_transversum is_a: UBERON:0003104 ! mesenchyme relationship: located_in UBERON:0002323 ! coelemic cavity lumen relationship: part_of UBERON:0002100 ! trunk property_value: UBPROP:0000001 "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000019", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/transverse+septum"} property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000019", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "The cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm. The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut." xsd:string property_value: UBPROP:0000012 "in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum" xsd:string {external_ontology="EHDAA2"} [Term] id: UBERON:0004175 name: internal genitalia namespace: uberon def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [GO:0035260] comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "internal genitalia" EXACT [] synonym: "internal genitals" EXACT [] synonym: "internal reproductive organ" RELATED [] synonym: "internal sex organ" RELATED [] xref: FMA:45652 is_a: UBERON:0003133 ! reproductive organ property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004176 name: external genitalia namespace: uberon def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [GO:0035261] comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "external genitalia" EXACT [] synonym: "external reproductive organ" RELATED [] synonym: "external sex organ" RELATED [] xref: FMA:45643 xref: SCTID:362207005 is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0004177 name: hemopoietic organ namespace: uberon def: "Organ that is part of the hematopoietic system." [GOC:Obol] subset: human_subset subset: mouse_subset subset: organ_slim subset: pheno_slim synonym: "haematological system organ" EXACT [OBOL:automatic] synonym: "haemopoietic system organ" EXACT [OBOL:automatic] synonym: "hematopoeitic or lymphoid organ" NARROW [] synonym: "hematopoeitic organ" EXACT [] synonym: "hematopoietic system organ" EXACT [OBOL:automatic] synonym: "lymph organ" NARROW [MA:0000747] synonym: "lymphoid organ" NARROW [BTO:0004605, FMA:7143] synonym: "organ of haematological system" EXACT [OBOL:automatic] synonym: "organ of haemopoietic system" EXACT [OBOL:automatic] synonym: "organ of hematopoietic system" EXACT [OBOL:automatic] synonym: "organ of organa haemopoietica" EXACT [OBOL:automatic] synonym: "organa haemopoietica organ" EXACT [OBOL:automatic] xref: BTO:0004605 xref: EMAPA:37665 {source="MA:th"} xref: FMA:7143 xref: MA:0000747 xref: SCTID:361338006 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: part_of UBERON:0002390 ! hematopoietic system relationship: part_of UBERON:0002390 ! hematopoietic system property_value: editor_note "consider splitting out lymph organ, compare with lymph node" xsd:string property_value: UBPROP:0000001 "the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]." xsd:string {source="http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs"} property_value: UBPROP:0000012 "the FMA class 'lymphoid organ' is a general anatomical term" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0004178 name: aorta smooth muscle tissue namespace: uberon def: "The nonstriated, involuntary muscle tissue located in the wall of the aorta." [MGI:csmith, MP:0009865] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "aorta non-striated muscle" EXACT [OBOL:automatic] synonym: "aorta smooth muscle" EXACT [OBOL:automatic] synonym: "aortic smooth muscle" EXACT [BTO:0001685] xref: BTO:0001685 xref: CALOHA:TS-0048 xref: EFO:0002775 xref: EMAPA:35135 xref: MA:0000702 xref: NCIT:C49191 xref: UMLS:C1706825 {source="ncithesaurus:Aorta_Smooth_Muscle_Tissue"} is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000947 ! aorta relationship: part_of UBERON:0000947 ! aorta [Term] id: UBERON:0004185 name: endodermal part of digestive tract namespace: uberon def: "A portions of the gut that is derived from endoderm." [GO:0061031] subset: human_subset subset: mouse_subset synonym: "endodermal gut" EXACT [] synonym: "gut endoderm" EXACT [EMAPA:32930] xref: EMAPA:32930 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001555 ! digestive tract [Term] id: UBERON:0004215 name: back nerve namespace: uberon def: "A nerve that is part of a back [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "nerve of back" EXACT [OBOL:automatic] xref: EMAPA:37268 {source="MA:th"} xref: MA:0000497 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004220 name: large intestine smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "involuntary muscle of large intestine" EXACT [OBOL:automatic] synonym: "large intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "large intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "large intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of large intestine" EXACT [OBOL:automatic] synonym: "smooth muscle of large intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of large intestine" EXACT [OBOL:automatic] xref: EMAPA:35469 xref: MA:0001547 is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000059 ! large intestine relationship: overlaps UBERON:0011198 {notes="consider merging"} ! muscle layer of large intestine relationship: part_of UBERON:0001169 {source="MA"} ! wall of large intestine property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} [Term] id: UBERON:0004221 name: intestine smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "bowel involuntary muscle" EXACT [OBOL:automatic] synonym: "bowel non-striated muscle" EXACT [OBOL:automatic] synonym: "bowel smooth muscle" EXACT [OBOL:automatic] synonym: "bowel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "intestinal muscularis" RELATED [EMAPA:35441] synonym: "intestinal smooth muscle" RELATED [BTO:0000643] synonym: "intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bowel" EXACT [OBOL:automatic] synonym: "involuntary muscle of intestine" EXACT [OBOL:automatic] synonym: "non-striated muscle of bowel" EXACT [OBOL:automatic] synonym: "non-striated muscle of intestine" EXACT [OBOL:automatic] synonym: "smooth muscle of bowel" EXACT [OBOL:automatic] synonym: "smooth muscle of intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bowel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of intestine" EXACT [OBOL:automatic] xref: BTO:0000643 xref: EMAPA:35441 xref: EMAPA:35443 xref: MA:0001539 xref: NCIT:C49243 xref: UMLS:C1708547 {source="ncithesaurus:Intestinal_Smooth_Muscle_Tissue"} is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000160 ! intestine relationship: contributes_to_morphology_of UBERON:0000160 ! intestine relationship: overlaps UBERON:0012367 {notes="consider merging"} ! muscle layer of intestine relationship: part_of UBERON:0001262 ! wall of intestine property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} [Term] id: UBERON:0004222 name: stomach smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "gastric muscle" RELATED [BTO:0001818] synonym: "gastric smooth muscle" RELATED [MA:0001627] synonym: "involuntary muscle of stomach" EXACT [OBOL:automatic] synonym: "involuntary muscle of ventriculus" EXACT [OBOL:automatic] synonym: "non-striated muscle of stomach" EXACT [OBOL:automatic] synonym: "non-striated muscle of ventriculus" EXACT [OBOL:automatic] synonym: "smooth muscle of stomach" EXACT [OBOL:automatic] synonym: "smooth muscle of ventriculus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of stomach" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of ventriculus" EXACT [OBOL:automatic] synonym: "stomach involuntary muscle" EXACT [OBOL:automatic] synonym: "stomach muscle" RELATED [BTO:0001818] synonym: "stomach non-striated muscle" EXACT [OBOL:automatic] synonym: "stomach smooth muscle tissue" EXACT [OBOL:automatic] synonym: "ventriculus involuntary muscle" EXACT [OBOL:automatic] synonym: "ventriculus non-striated muscle" EXACT [OBOL:automatic] synonym: "ventriculus smooth muscle" EXACT [OBOL:automatic] synonym: "ventriculus smooth muscle tissue" EXACT [OBOL:automatic] xref: BTO:0001818 xref: EMAPA:35823 xref: MA:0001627 is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001167 ! wall of stomach [Term] id: UBERON:0004225 name: respiratory system smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "airway smooth muscle" RELATED [BTO:0001660] synonym: "airway smooth muscle cell" RELATED [BTO:0001660] synonym: "respiratory smooth muscle" EXACT [BTO:0001660] synonym: "smooth muscle of respiratory system" EXACT [OBOL:automatic] xref: BTO:0001660 xref: EMAPA:35734 xref: MA:0001830 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system [Term] id: UBERON:0004226 name: gastrointestinal system smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "smooth muscle tissue of gastrointestinal system" EXACT [OBOL:automatic] xref: EMAPA:35117 xref: MA:0001523 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system [Term] id: UBERON:0004231 name: anal region smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "anal part of perineum involuntary muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum non-striated muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum smooth muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum smooth muscle tissue" EXACT [OBOL:automatic] synonym: "anal region involuntary muscle" EXACT [OBOL:automatic] synonym: "anal region non-striated muscle" EXACT [OBOL:automatic] synonym: "anal region smooth muscle tissue" EXACT [OBOL:automatic] synonym: "anal triangle involuntary muscle" EXACT [OBOL:automatic] synonym: "anal triangle non-striated muscle" EXACT [OBOL:automatic] synonym: "anal triangle smooth muscle" EXACT [OBOL:automatic] synonym: "anal triangle smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal region" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal triangle" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal region" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal triangle" EXACT [OBOL:automatic] synonym: "smooth muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "smooth muscle of anal region" EXACT [OBOL:automatic] synonym: "smooth muscle of anal triangle" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal part of perineum" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal region" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal triangle" EXACT [OBOL:automatic] xref: EMAPA:37394 {source="MA:th"} xref: MA:0001532 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0004233 name: lower respiratory tract smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "involuntary muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "lower respiratory tract involuntary muscle" EXACT [OBOL:automatic] synonym: "lower respiratory tract non-striated muscle" EXACT [OBOL:automatic] synonym: "lower respiratory tract smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "smooth muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:35520 xref: MA:0002410 is_a: UBERON:0004225 ! respiratory system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001558 ! lower respiratory tract relationship: part_of UBERON:0001558 ! lower respiratory tract [Term] id: UBERON:0004234 name: iris smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "involuntary muscle of iris" EXACT [OBOL:automatic] synonym: "iridial smooth muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "iris involuntary muscle" EXACT [OBOL:automatic] synonym: "iris non-striated muscle" EXACT [OBOL:automatic] synonym: "iris smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of iris" EXACT [OBOL:automatic] synonym: "smooth muscle of iris" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of iris" EXACT [OBOL:automatic] xref: BTO:0000655 xref: EMAPA:35448 xref: FMA:312338 xref: MA:0001270 is_a: UBERON:0003386 {source="MA"} ! smooth muscle of eye intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001606 ! muscle of iris property_value: editor_note "see notes for muscle of iris." xsd:string [Term] id: UBERON:0004236 name: arteriole smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset xref: EMAPA:36287 xref: FMA:312251 xref: MA:0000706 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole [Term] id: UBERON:0004237 name: blood vessel smooth muscle namespace: uberon alt_id: UBERON:0010508 def: "Smooth muscle found within, and composing the majority of the wall of blood vessels." [Wikipedia:Vascular_smooth_muscle] subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "blood vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "blood vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "blood vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of blood vessel" EXACT [OBOL:automatic] synonym: "non-striated muscle of blood vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of blood vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of blood vessel" EXACT [OBOL:automatic] synonym: "vascular smooth muscle" EXACT [ZFA:0005321] synonym: "vascular smooth muscle tissue" EXACT [] xref: BTO:0001431 xref: CALOHA:TS-1107 xref: EMAPA:35177 xref: MA:0000710 xref: MESH:D009131 xref: NCIT:C33853 xref: TAO:0005321 xref: UMLS:C1519956 {source="ncithesaurus:Vascular_Smooth_Muscle_Tissue"} xref: Wikipedia:Vascular_smooth_muscle xref: ZFA:0005321 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension." xsd:string [Term] id: UBERON:0004238 name: spleen smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "involuntary muscle of spleen" EXACT [OBOL:automatic] synonym: "non-striated muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of spleen" EXACT [OBOL:automatic] synonym: "spleen involuntary muscle" EXACT [OBOL:automatic] synonym: "spleen non-striated muscle" EXACT [OBOL:automatic] synonym: "spleen smooth muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:35807 xref: MA:0000757 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004239 name: small intestine smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "involuntary muscle of small bowel" EXACT [OBOL:automatic] synonym: "involuntary muscle of small intestine" EXACT [OBOL:automatic] synonym: "non-striated muscle of small bowel" EXACT [OBOL:automatic] synonym: "non-striated muscle of small intestine" EXACT [OBOL:automatic] synonym: "small bowel involuntary muscle" EXACT [OBOL:automatic] synonym: "small bowel non-striated muscle" EXACT [OBOL:automatic] synonym: "small bowel smooth muscle" EXACT [OBOL:automatic] synonym: "small bowel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "small intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "small intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "small intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of small bowel" EXACT [OBOL:automatic] synonym: "smooth muscle of small intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of small bowel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of small intestine" EXACT [OBOL:automatic] xref: EMAPA:35783 xref: MA:0001559 is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002108 ! small intestine relationship: overlaps UBERON:0011201 {notes="consider merging"} ! muscle layer of small intestine relationship: part_of UBERON:0001168 ! wall of small intestine property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} [Term] id: UBERON:0004240 name: gallbladder smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "biliary smooth muscle" RELATED [MA:0001635] synonym: "gall bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "gall bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "gall bladder smooth muscle" EXACT [OBOL:automatic] synonym: "gall bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "gallbladder involuntary muscle" EXACT [OBOL:automatic] synonym: "gallbladder non-striated muscle" EXACT [OBOL:automatic] synonym: "gallbladder smooth muscle tissue" EXACT [] synonym: "involuntary muscle of gall bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of gallbladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of gall bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of gallbladder" EXACT [OBOL:automatic] synonym: "smooth muscle of gall bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of gallbladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gall bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gallbladder" EXACT [OBOL:automatic] xref: EMAPA:35373 xref: MA:0001635 xref: NCIT:C49483 xref: UMLS:C1708179 {source="ncithesaurus:Gallbladder_Smooth_Muscle_Tissue"} is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: UBERON:0004242 name: bronchus smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "bronchi involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchi non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchi smooth muscle" EXACT [OBOL:automatic] synonym: "bronchi smooth muscle tissue" EXACT [OBOL:automatic] synonym: "bronchial smooth muscle" RELATED [EMAPA:35195] synonym: "bronchial trunk involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk smooth muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk smooth muscle tissue" EXACT [OBOL:automatic] synonym: "bronchus involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchus non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchi" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchus" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchi" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchus" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchi" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchi" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchus" EXACT [OBOL:automatic] xref: BTO:0004401 xref: EMAPA:35195 xref: MA:0001840 xref: NCIT:C49213 xref: UMLS:C1707055 {source="ncithesaurus:Bronchus_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002185 ! bronchus relationship: has_part CL:0002598 ! bronchial smooth muscle cell relationship: part_of UBERON:0002185 ! bronchus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004246 name: outflow tract smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "involuntary muscle of outflow tract" EXACT [OBOL:automatic] synonym: "non-striated muscle of outflow tract" EXACT [OBOL:automatic] synonym: "outflow tract involuntary muscle" EXACT [OBOL:automatic] synonym: "outflow tract non-striated muscle" EXACT [OBOL:automatic] synonym: "outflow tract smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of outflow tract" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of outflow tract" EXACT [OBOL:automatic] xref: EMAPA:37708 {source="MA:th"} xref: MA:0000492 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004247 name: bone of dorsum namespace: uberon def: "A bone that is part of the dorsal region of an animal." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_subset subset: mouse_subset synonym: "back bone" RELATED [MA:0000494] synonym: "bone of back" RELATED [OBOL:automatic] synonym: "dorsal region bone" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37248 {source="MA:th"} xref: MA:0000494 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0001137 ! dorsum property_value: IAO:0000232 "this class may be obsoleted. See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/93" xsd:string property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI [Term] id: UBERON:0004253 name: skin muscle namespace: uberon alt_id: UBERON:0015797 def: "Any muscle organ that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "integumental system muscle" EXACT [MA:0003139] synonym: "muscle of integumental system" EXACT [EMAPA:18187] synonym: "muscle organ of skin" EXACT [OBOL:automatic] synonym: "skin muscle organ" EXACT [OBOL:automatic] xref: EMAPA:18187 xref: EMAPA:35776 xref: MA:0002710 xref: MA:0003139 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0002416 ! integumental system relationship: located_in UBERON:0002097 ! skin of body relationship: part_of UBERON:0002416 ! integumental system property_value: editor_note "review as part of general integumentary system review - part of skin, or more generally, integumental system" xsd:string property_value: UBPROP:0000012 "in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only" xsd:string {external_ontology="MA"} [Term] id: UBERON:0004258 name: back blood vessel namespace: uberon def: "A blood vessel that is part of a back [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "blood vessel of back" EXACT [OBOL:automatic] xref: EMAPA:37243 {source="MA:th"} xref: MA:0000493 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004265 name: outflow tract myocardium namespace: uberon def: "A myocardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "cardiac muscle of outflow tract" EXACT [OBOL:automatic] synonym: "heart muscle of outflow tract" EXACT [OBOL:automatic] synonym: "heart myocardium of outflow tract" EXACT [OBOL:automatic] synonym: "muscle of heart of outflow tract" EXACT [OBOL:automatic] synonym: "myocardium of outflow tract" EXACT [OBOL:automatic] synonym: "outflow tract cardiac muscle" EXACT [OBOL:automatic] synonym: "outflow tract heart muscle" EXACT [OBOL:automatic] synonym: "outflow tract heart myocardium" EXACT [OBOL:automatic] synonym: "outflow tract muscle of heart" EXACT [OBOL:automatic] xref: EHDAA2:0001358 xref: EMAPA:35623 xref: MA:0000489 xref: VHOG:0000603 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract property_value: UBPROP:0000003 "(...) (theme) is how the vertebrate cardiovascular system differs from that of the presumptive evolutionary chordate ancestor. (...) At best we can tell there are two essential new ingredients: (1) vertebrates all have a continuous endothelial lining to the heart and vessels and (2) vertebrates have developed a second chamber in the heart, one designed for generating high systemic blood pressure.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000603", ontology="VHOG", source="PMID:9187138 Fishman MC, Chien KR, Fashioning the vertebrate heart: earliest embryonic decisions. Development (1997)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0004267 name: back connective tissue namespace: uberon def: "A portion of connective tissue that is part of a back [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "mesenchyne of back" RELATED [OBOL:automatic] xref: EMAPA:37256 {source="MA:th"} xref: MA:0000495 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum [Term] id: UBERON:0004271 name: outflow tract pericardium namespace: uberon def: "A pericardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "pericardium of outflow tract" EXACT [OBOL:automatic] xref: EMAPA:37707 {source="MA:th"} xref: MA:0000491 is_a: UBERON:0002407 ! pericardium intersection_of: UBERON:0002407 ! pericardium intersection_of: part_of UBERON:0004145 ! outflow tract relationship: part_of UBERON:0004145 ! outflow tract [Term] id: UBERON:0004277 name: eye muscle namespace: uberon def: "A muscle that is part of the eye region." [OBOL:automatic] subset: human_subset subset: mouse_subset subset: pheno_slim xref: AAO:0000156 xref: EMAPA:35335 xref: MA:0000271 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 {source="MA"} ! camera-type eye [Term] id: UBERON:0004288 name: skeleton namespace: uberon def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." [VSAO:0000026] subset: efo_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim synonym: "set of all bones" EXACT [] synonym: "set of bones of body" EXACT [] xref: AEO:0000168 xref: EHDAA2:0001843 xref: EHDAA:5047 xref: EMAPA:17213 xref: FMA:23875 xref: GAID:177 xref: galen:Skeleton xref: MA:0003006 xref: MAT:0000032 xref: MESH:D012863 xref: MIAA:0000032 xref: SCTID:361378004 xref: VSAO:0000026 xref: Wikipedia:Skeleton xref: XAO:0004053 is_a: UBERON:0034925 ! anatomical collection disjoint_from: UBERON:0004770 ! articular system relationship: has_member UBERON:0004765 ! skeletal element relationship: part_of UBERON:0001434 ! skeletal system property_value: RO:0002171 UBERON:0000383 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/The-skeletal-system xsd:anyURI property_value: UBPROP:0000001 "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000026", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070"} property_value: UBPROP:0000007 "skeletal" xsd:string [Term] id: UBERON:0004290 name: dermomyotome namespace: uberon def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:0000214] subset: human_subset subset: mouse_subset synonym: "dermamyotome" RELATED [VHOG:0000676] synonym: "dermomyotomes" RELATED OMO:0003004 [VHOG:0000676] xref: AAO:0010572 xref: AEO:0000214 xref: EHDAA2:0003259 xref: EMAPA:31109 xref: FMA:295654 xref: NCIT:C34140 xref: TAO:0001513 xref: UMLS:C1511786 {source="ncithesaurus:Dermomyotome"} xref: VHOG:0000676 xref: ZFA:0001513 is_a: UBERON:0000486 {source="AEO"} ! multilaminar epithelium is_a: UBERON:0016888 {source="AEO"} ! transitional anatomical structure relationship: develops_from UBERON:0002329 {source="EHDAA2", source="ZFA"} ! somite relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell property_value: UBPROP:0000001 "all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis." xsd:string {source="http://medical-dictionary.thefreedictionary.com/dermomyotome"} property_value: UBPROP:0000001 "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]." xsd:string {source="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768"} property_value: UBPROP:0000001 "Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001513", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Portion of somites that gives rise to dermis and muscles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010572", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000676", ontology="VHOG", source="DOI:10.1111/j.1525-142X.2006.05079.x Devoto SH, Stoiber W, Hammond CL, Steinbacher P, Haslett JR, Barresi MJF, Patterson SE, Adiarte EG and Hughes SM, Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Evolution and Development (2006)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0004291 name: heart rudiment namespace: uberon def: "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GO:0003313] subset: human_subset subset: mouse_subset synonym: "heart cone" EXACT [GO:0003313] synonym: "rudimentary heart" EXACT [ZFA:0000115] xref: TAO:0000115 xref: ZFA:0000115 is_a: UBERON:0012275 ! meso-epithelium relationship: develops_from UBERON:0004139 ! cardiogenic plate property_value: UBPROP:0000001 "The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000115", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0004292 name: cardiac skeleton namespace: uberon def: "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." [GO:0003204, Wikipedia:Cardiac_skeleton] subset: human_subset subset: mouse_subset synonym: "anulus fibrosus dexter cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "anulus fibrosus sinister cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "cardiac fibrous skeleton" EXACT [EMAPA:36645] synonym: "fibrous skeleton of heart" EXACT [] synonym: "heart fibrous skeleton" EXACT [GO:0003204] synonym: "skeleton of heart" EXACT [FMA:9496] synonym: "trigona fibrosa" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "trigonum fibrosum dextrum cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "trigonum fibrosum sinistrum cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] xref: EMAPA:36645 xref: FMA:9496 xref: Wikipedia:Cardiac_skeleton is_a: UBERON:0003837 ! thoracic segment connective tissue relationship: adjacent_to UBERON:0002081 ! cardiac atrium relationship: adjacent_to UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0000948 ! heart property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png xsd:anyURI property_value: UBPROP:0000009 "It is not a true skeleton, but it does provide structure and support for the heart, as well as isolating the atria from the ventricles. This allows the AV node and AV bundle to delay the wave of depolarisation such that the atria can contract and assist in ventricular filling before the ventricles themselves depolarise and contract (the AV bundle is the only part of the conduction system that passes from the atria to the ventricles in a normal heart). It also allows the valves (bicuspid, tricuspid, semilunar) to keep open by giving them structural support[WP]" xsd:string [Term] id: UBERON:0004297 name: respiratory system blood vessel smooth muscle namespace: uberon def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_subset subset: mouse_subset synonym: "smooth muscle tissue of blood vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37573 {source="MA:th"} xref: MA:0001806 is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003504 ! respiratory system blood vessel relationship: part_of UBERON:0003504 ! respiratory system blood vessel [Term] id: UBERON:0004345 name: trophectoderm namespace: uberon def: "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." [MP:0005028] subset: early_development subset: human_subset subset: mouse_subset subset: pheno_slim xref: BTO:0001840 xref: EHDAA2:0002091 xref: EHDAA:56 xref: EMAPA:16046 xref: VHOG:0000979 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: develops_from UBERON:0000085 {source="EHDAA2"} ! morula relationship: has_part CL:1000274 ! trophectodermal cell relationship: part_of UBERON:0005631 {source="EHDAA2"} ! extraembryonic membrane property_value: editor_note "distinction between trophectoderm and trophoblast unclear/inconsistent in many sources" xsd:string property_value: UBPROP:0000001 "The outer cellular layer of the mammalian blastocyst. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.750, see_Kardong_KV][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000979", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "(...) the trophoblast develops rapidly so that contact may be made with the maternal uterine tissues when conditions are appropriate. We have here an excellent example of an embryonic adaptation, the development of a structure never present in either adult or embryo of 'lower' vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000979", ontology="VHOG", source="ISBN:978-0721676685 Romer AS, Parsons TS, Vertebrate body (1977) p.105-106", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "trophectodermal" xsd:string property_value: UBPROP:0000012 "BTO has this has part of the trophoblast" xsd:string {external_ontology="BTO"} [Term] id: UBERON:0004348 name: optic eminence namespace: uberon def: "The embryonic structure that gives rise to the corneal ectoderm." [MP:0006305] subset: human_subset subset: mouse_subset subset: pheno_slim xref: EHDAA:938 xref: EMAPA:16322 xref: RETIRED_EHDAA2:0001308 xref: VHOG:0001296 is_a: UBERON:0006598 ! presumptive structure relationship: has_potential_to_develop_into UBERON:0000964 ! cornea [Term] id: UBERON:0004356 name: apical ectodermal ridge namespace: uberon def: "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." [MP:0001676, Wikipedia:Apical_ectodermal_ridge] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "AER" RELATED [MP:0001676] synonym: "apical epidermal ridge" EXACT [XAO:0004121] synonym: "crista ectodermalis apicalis" RELATED OMO:0003011 [Wikipedia:Apical_ectodermal_ridge] xref: AAO:0010760 xref: EMAPA:32744 xref: NCIT:C34109 xref: TAO:0002146 xref: UMLS:C1516037 {source="ncithesaurus:Apical_Ectodermal_Ridge"} xref: Wikipedia:Apical_ectodermal_ridge xref: XAO:0004121 xref: ZFA:0001702 is_a: UBERON:0002050 ! embryonic structure relationship: capable_of GO:0010464 ! regulation of mesenchymal cell proliferation relationship: capable_of GO:0061037 ! negative regulation of cartilage development relationship: developmentally_induced_by UBERON:0003104 ! mesenchyme relationship: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0004357 ! paired limb/fin bud relationship: produces PR:000007499 ! fibroblast growth factor 8 property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg xsd:anyURI property_value: IAO:0000232 "note that media, dorsal fins etc have AERs." xsd:string property_value: UBPROP:0000001 "Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010760", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Proliferative region that is part of the developing fin fold or fin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002146", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: subclass proliferative region (TAO:0000098)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002146", ontology="TAO"} property_value: UBPROP:0000008 "The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold" xsd:string {source="PMID:20574421"} property_value: UBPROP:0000009 "maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop" xsd:string [Term] id: UBERON:0004357 name: paired limb/fin bud namespace: uberon def: "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." [https://orcid.org/0000-0002-6601-2165, ISBN:9780878932504, MP:0005650] comment: Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] subset: homology_grouping subset: human_subset subset: mouse_subset synonym: "limb - fin bud" EXACT [VHOG:0001258] synonym: "paired appendage bud" EXACT [] synonym: "paired limb/fin bud" EXACT [VHOG:0001258] xref: VHOG:0001258 is_a: UBERON:0003102 ! surface structure is_a: UBERON:0006598 ! presumptive structure relationship: has_developmental_contribution_from UBERON:0005732 ! paired limb/fin field relationship: has_part UBERON:0004356 ! apical ectodermal ridge relationship: has_potential_to_develop_into UBERON:0004708 ! paired limb/fin property_value: UBPROP:0000003 "The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001258", ontology="VHOG", source="DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", source="http://bgee.unil.ch/"} [Term] id: UBERON:0004362 name: pharyngeal arch 1 namespace: uberon def: "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "1st arch" RELATED [EHDAA2:0000006] synonym: "1st pharyngeal arch" EXACT [] synonym: "1st visceral arch" RELATED [VHOG:0000296] synonym: "arcus pharyngeus primus" RELATED OMO:0003011 [Wikipedia:First_pharyngeal_arch] synonym: "branchial arch 1" EXACT SENSU [] synonym: "first branchial arch" EXACT SENSU [] synonym: "first pharyngeal arch" EXACT [] synonym: "first visceral arch" EXACT SENSU [] synonym: "mandibular arch" EXACT [] synonym: "visceral arch 1" EXACT SENSU [] xref: AAO:0010364 xref: CALOHA:TS-2089 xref: EHDAA2:0000006 xref: EHDAA:573 xref: EMAPA:16118 xref: FMA:293019 xref: MFMO:0000095 xref: NCIT:C34175 xref: SCTID:308767008 xref: TAO:0001595 xref: UMLS:C1517197 {source="ncithesaurus:First_Pharyngeal_Arch"} xref: VHOG:0000296 xref: Wikipedia:First_pharyngeal_arch xref: XAO:0000097 xref: ZFA:0001612 is_a: UBERON:0002539 ! pharyngeal arch property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png xsd:anyURI property_value: UBPROP:0000001 "the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" xsd:string {source="MP:0006337,MGI:smb"} property_value: UBPROP:0000001 "The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010364", ontology="AAO", source="XAO:EJS"} property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000296", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000103 "1" xsd:nonNegativeInteger [Term] id: UBERON:0004363 name: pharyngeal arch artery namespace: uberon alt_id: UBERON:0004342 def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." [MP:0002672] subset: efo_slim subset: human_subset subset: mouse_subset subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "a. arcuum pharyngeorum" RELATED OMO:0003011 [Wikipedia:Aortic_arches] synonym: "aortic arch" EXACT [ZFA:0005004] synonym: "aortic arch artery" RELATED [EMAPA:16684] synonym: "aortic arches" EXACT OMO:0003004 [ZFA:0005004] synonym: "arteriae arcuum pharyngeorum" RELATED OMO:0003011 [Wikipedia:Aortic_arches] synonym: "branchial aortic arches" EXACT OMO:0003004 [ZFIN:ZDB-PUB-080512-6] synonym: "branchial aortic arches" RELATED OMO:0003004 [ZFA:0005004, ZFIN:ZDB-PUB-080512-6] synonym: "branchial arch artery" EXACT [EMAPA:16684] synonym: "embryonic aortic arch artery" EXACT [EMAPA:16684, MP:0002672] synonym: "PAA" EXACT OMO:0003000 [MP:0002672] synonym: "pharyngeal arch arteries" RELATED OMO:0003004 [] synonym: "pharyngeal arch artery" EXACT [MP:0002672] synonym: "pharyngeal arch artery" RELATED [VHOG:0000122] xref: AAO:0010414 xref: EFO:0003695 xref: EHDAA2:0000186 xref: EHDAA:398 xref: EHDAA:7327 xref: EMAPA:16684 xref: NCIT:C32123 xref: TAO:0005004 xref: UMLS:C0003489 {source="ncithesaurus:Aortic_Arch"} xref: VHOG:0000122 xref: Wikipedia:Aortic_arches xref: XAO:0000341 xref: ZFA:0005004 is_a: UBERON:0003469 ! respiratory system artery is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: contributes_to_morphology_of UBERON:0002539 ! pharyngeal arch relationship: has_potential_to_develop_into UBERON:0001637 ! artery relationship: part_of UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0007303 {source="ZFA"} ! pharyngeal vasculature property_value: editor_note "add specific artery derivatives" xsd:string property_value: http://xmlns.com/foaf/0.1/depiction http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png xsd:anyURI property_value: IAO:0000232 "Do not confuse with arch of aorta." xsd:string property_value: UBPROP:0000001 "Paired vessels arching from the ventral to the dorsal aorta through the pharyngeal arches. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000122", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aortic+arches"} property_value: UBPROP:0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000122", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "Number varies - Lampreys have 8, hagfishes 15; only up to 6 appear in embryonic development in most gnathostome fishes and all tetrapods" xsd:string property_value: UBPROP:0000011 "The third, fourth, and sixth arches, along with the seventh intersegmental arteries and the left dorsal aorta, are the primary contributors to the normal aortic arch and its major thoracic branches" xsd:string [Term] id: UBERON:0004364 name: ectoplacental cone namespace: uberon def: "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta." [MP:0001717, PMID:19829370] subset: human_subset subset: mouse_subset subset: pheno_slim synonym: "epamniotic cone" EXACT [] synonym: "placenta - ectoplacental cone" EXACT [] xref: BTO:0001715 xref: EMAPA:16059 is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000088 ! trophoblast property_value: UBPROP:0000011 "derivative of the early postimplantation trophoblast, which probably gives rise to the spongiotrophoblast." xsd:string {source="PMID:19829370"} [Term] id: UBERON:0004365 name: vitelline blood vessel namespace: uberon def: "Blood vessel that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] subset: human_subset subset: mouse_subset subset: pheno_slim xref: EMAPA:36494 is_a: UBERON:000198