format-version: 1.2 data-version: releases/2024-08-22 subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" subsetdef: blood_and_immune_upper_slim "" subsetdef: cell_quality "" subsetdef: cellxgene_subset "" subsetdef: common_anatomy "" subsetdef: cumbo "" subsetdef: developmental_classification "" subsetdef: disposition_slim "" subsetdef: early_development "" subsetdef: efo_slim "" subsetdef: emapa_ehdaa2 "" subsetdef: eye_upper_slim "" subsetdef: functional_classification "" subsetdef: general_cell_types_upper_slim "" subsetdef: gocheck_do_not_annotate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_euk_cellular_processes_ribbon "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_plant_ribbon "" subsetdef: goslim_pombe "" subsetdef: goslim_prokaryote "" subsetdef: goslim_prokaryote_ribbon "" subsetdef: goslim_synapse "" subsetdef: goslim_yeast "" subsetdef: grouping_class "" subsetdef: homology_grouping "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: human_reference_atlas "" subsetdef: inconsistent_with_fma "" subsetdef: location_grouping "" subsetdef: major_organ "" subsetdef: mpath_slim "" subsetdef: non_informative "" subsetdef: organ_slim "" subsetdef: pheno_slim "" subsetdef: phenotype_rcn "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: uberon_slim "" subsetdef: ubprop:upper_level "" subsetdef: unverified_taxonomic_grouping "" subsetdef: upper_level "" subsetdef: value_slim "" subsetdef: vertebrate_core "" ontology: ecao property_value: http://purl.org/dc/elements/1.1/description "None" xsd:string property_value: http://purl.org/dc/elements/1.1/title "Echinoderm Anatomy and Development Ontology" xsd:string property_value: http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/3.0/ [Term] id: BFO:0000001 name: entity property_value: BFO:0000179 "entity" xsd:string property_value: BFO:0000180 "Entity" xsd:string property_value: editor_note "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string property_value: editor_note "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", http://www.w3.org/2000/01/rdf-schema#seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"} property_value: IAO:0000112 "Julius Caesar" xsd:string property_value: IAO:0000112 "the Second World War" xsd:string property_value: IAO:0000112 "Verdi’s Requiem" xsd:string property_value: IAO:0000112 "your body mass index" xsd:string property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant property_value: BFO:0000179 "continuant" xsd:string property_value: BFO:0000180 "Continuant" xsd:string property_value: editor_note "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string property_value: editor_note "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"} property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 ! occurrent property_value: editor_note "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string property_value: editor_note "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string property_value: IAO:0000589 "processual entity (BFO)" xsd:string [Term] id: BFO:0000004 name: independent continuant def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! characteristic disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000004 ! independent continuant property_value: BFO:0000179 "ic" xsd:string property_value: BFO:0000180 "IndependentContinuant" xsd:string property_value: IAO:0000112 "a chair" xsd:string property_value: IAO:0000112 "a heart" xsd:string property_value: IAO:0000112 "a leg" xsd:string property_value: IAO:0000112 "a molecule" xsd:string property_value: IAO:0000112 "a spatial region" xsd:string property_value: IAO:0000112 "an atom" xsd:string property_value: IAO:0000112 "an orchestra." xsd:string property_value: IAO:0000112 "an organism" xsd:string property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string property_value: IAO:0000112 "the interior of your mouth" xsd:string property_value: IAO:0000589 "anatomical entity (BFO)" xsd:string property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000006 name: spatial region is_a: BFO:0000141 ! immaterial entity property_value: editor_note "BFO 2 Reference: Spatial regions do not participate in processes." xsd:string [Term] id: BFO:0000015 name: process def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. is_a: BFO:0000003 ! occurrent property_value: editor_note "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string property_value: IAO:0000112 "a process of meiosis" xsd:string property_value: IAO:0000112 "a process of sleeping" xsd:string property_value: IAO:0000112 "the course of a disease" xsd:string property_value: IAO:0000112 "the flight of a bird" xsd:string property_value: IAO:0000112 "the life of an organism" xsd:string property_value: IAO:0000112 "your process of aging." xsd:string [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role [Term] id: BFO:0000017 name: realizable name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! characteristic disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 ! realizable entity property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string property_value: IAO:0000112 "the function of your reproductive organs" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! characteristic relationship: part_of BFO:0000019 ! quality property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string property_value: IAO:0000112 "the color of a tomato" xsd:string property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string property_value: IAO:0000112 "the mass of this piece of gold." xsd:string property_value: IAO:0000112 "the shape of your nose" xsd:string property_value: IAO:0000112 "the shape of your nostril" xsd:string [Term] id: BFO:0000020 name: characteristic name: specifically dependent continuant def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 ! characteristic property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the shape of this hole." xsd:string property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string property_value: seeAlso https://github.com/OBOFoundry/COB/issues/65 xsd:string property_value: seeAlso https://github.com/oborel/obo-relations/pull/284 xsd:string [Term] id: BFO:0000023 name: role def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] is_a: BFO:0000017 ! realizable entity property_value: editor_note "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives." xsd:string property_value: IAO:0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string property_value: IAO:0000112 "the priest role" xsd:string property_value: IAO:0000112 "the role of a boundary to demarcate two neighboring administrative territories" xsd:string property_value: IAO:0000112 "the role of a building in serving as a military target" xsd:string property_value: IAO:0000112 "the role of a stone in marking a property boundary" xsd:string property_value: IAO:0000112 "the role of subject in a clinical trial" xsd:string property_value: IAO:0000112 "the student role" xsd:string [Term] id: BFO:0000031 name: generically dependent continuant is_a: BFO:0000002 ! continuant property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string [Term] id: BFO:0000034 name: function is_a: BFO:0000016 ! disposition [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity property_value: BFO:0000179 "material" xsd:string property_value: BFO:0000180 "MaterialEntity" xsd:string property_value: editor_note "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string property_value: editor_note "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string property_value: editor_note "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string property_value: IAO:0000112 "a flame" xsd:string property_value: IAO:0000112 "a forest fire" xsd:string property_value: IAO:0000112 "a human being" xsd:string property_value: IAO:0000112 "a hurricane" xsd:string property_value: IAO:0000112 "a photon" xsd:string property_value: IAO:0000112 "a puff of smoke" xsd:string property_value: IAO:0000112 "a sea wave" xsd:string property_value: IAO:0000112 "a tornado" xsd:string property_value: IAO:0000112 "an aggregate of human beings." xsd:string property_value: IAO:0000112 "an energy wave" xsd:string property_value: IAO:0000112 "an epidemic" xsd:string property_value: IAO:0000112 "the undetached arm of a human being" xsd:string property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant property_value: editor_note "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10" xsd:string [Term] id: CARO:0000000 name: anatomical entity namespace: spatial def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH] [Term] id: CHEBI:10545 name: electron namespace: chebi_ontology def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." [] subset: 3_STAR synonym: "beta" RELATED [IUPAC] synonym: "beta(-)" RELATED [ChEBI] synonym: "beta-particle" RELATED [IUPAC] synonym: "e" RELATED [IUPAC] synonym: "e(-)" RELATED [UniProt] synonym: "e-" RELATED [KEGG_COMPOUND] synonym: "electron" EXACT [KEGG_COMPOUND] synonym: "electron" EXACT IUPAC_NAME [IUPAC] synonym: "electron" EXACT [ChEBI] synonym: "Elektron" RELATED [ChEBI] synonym: "negatron" RELATED [IUPAC] xref: KEGG:C05359 xref: PMID:21614077 {source="Europe PMC"} xref: Wikipedia:Electron is_a: CHEBI:36338 ! lepton [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives namespace: chebi_ontology def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." [] subset: 3_STAR synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI] is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:132153 name: hyaluronate namespace: chebi_ontology def: "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "hyaluronan" RELATED [UniProt] synonym: "hyaluronate polyanion" RELATED [ChEBI] is_a: CHEBI:61469 ! polyanionic polymer is_a: CHEBI:63551 ! carbohydrate acid derivative anion relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid [Term] id: CHEBI:136889 name: 5beta steroid namespace: chebi_ontology def: "Any steroid that has beta-configuration at position 5." [] subset: 3_STAR synonym: "5beta steroids" RELATED [ChEBI] synonym: "5beta-steroid" RELATED [ChEBI] synonym: "5beta-steroids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:138103 name: inorganic acid namespace: chebi_ontology def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." [] subset: 3_STAR synonym: "inorganic acids" RELATED [ChEBI] synonym: "mineral acid" RELATED [ChEBI] synonym: "mineral acids" RELATED [ChEBI] xref: Wikipedia:Mineral_acid is_a: CHEBI:39141 ! Bronsted acid [Term] id: CHEBI:138366 name: bile acids namespace: chebi_ontology def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." [] subset: 3_STAR is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:35350 ! hydroxy steroid is_a: CHEBI:36078 ! cholanoid [Term] id: CHEBI:138675 name: gas molecular entity namespace: chebi_ontology def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." [] subset: 3_STAR synonym: "gas molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entity" RELATED [ChEBI] xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:13941 name: carbamate namespace: chebi_ontology subset: 3_STAR synonym: "Carbamat" RELATED [ChEBI] synonym: "carbamate" EXACT [UniProt] synonym: "carbamate" EXACT IUPAC_NAME [IUPAC] synonym: "carbamate ion" RELATED [ChemIDplus] synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Karbamat" RELATED [ChEBI] xref: Beilstein:3903503 {source="Beilstein"} xref: CAS:302-11-4 {source="ChemIDplus"} xref: Gmelin:239604 {source="Gmelin"} is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid [Term] id: CHEBI:142163 name: 24G7 epitope namespace: chebi_ontology def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." [] subset: 3_STAR is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24433 ! group relationship: has_role CHEBI:53000 ! epitope [Term] id: CHEBI:15339 name: acceptor namespace: chebi_ontology alt_id: CHEBI:13699 alt_id: CHEBI:2377 def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." [] subset: 3_STAR synonym: "A" RELATED [KEGG_COMPOUND] synonym: "accepteur" RELATED [ChEBI] synonym: "Acceptor" EXACT [KEGG_COMPOUND] synonym: "Akzeptor" RELATED [ChEBI] synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND] synonym: "Oxidized donor" RELATED [KEGG_COMPOUND] xref: KEGG:C00028 xref: KEGG:C16722 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:15355 name: acetylcholine namespace: chebi_ontology alt_id: CHEBI:12686 alt_id: CHEBI:13715 alt_id: CHEBI:22197 alt_id: CHEBI:2416 alt_id: CHEBI:40559 def: "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." [] subset: 3_STAR synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "ACETYLCHOLINE" EXACT [PDBeChem] synonym: "Acetylcholine" EXACT [KEGG_COMPOUND] synonym: "acetylcholine" EXACT [UniProt] synonym: "ACh" RELATED [ChemIDplus] synonym: "Azetylcholin" RELATED [ChEBI] synonym: "choline acetate" RELATED [ChemIDplus] synonym: "O-Acetylcholine" RELATED [KEGG_COMPOUND] xref: Beilstein:1764436 {source="ChemIDplus"} xref: CAS:51-84-3 {source="KEGG COMPOUND"} xref: CAS:51-84-3 {source="ChemIDplus"} xref: Drug_Central:65 {source="DrugCentral"} xref: DrugBank:DB03128 xref: Gmelin:326108 {source="Gmelin"} xref: KEGG:C01996 xref: LINCS:LSM-5888 xref: PDBeChem:ACH xref: PMID:14764638 {source="Europe PMC"} xref: PMID:15014918 {source="Europe PMC"} xref: PMID:15231705 {source="Europe PMC"} xref: PMID:15361288 {source="Europe PMC"} xref: PMID:18050502 {source="Europe PMC"} xref: PMID:18407448 {source="Europe PMC"} xref: PMID:19255787 {source="Europe PMC"} xref: PMID:20963497 {source="Europe PMC"} xref: PMID:21130809 {source="Europe PMC"} xref: PMID:21246223 {source="Europe PMC"} xref: PMID:21545631 {source="Europe PMC"} xref: PMID:21601579 {source="Europe PMC"} xref: Wikipedia:Acetylcholine is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35287 ! acylcholine is_a: CHEBI:47622 ! acetate ester relationship: has_role CHEBI:24621 ! hormone relationship: has_role CHEBI:25512 ! neurotransmitter relationship: has_role CHEBI:35620 ! vasodilator agent relationship: has_role CHEBI:38325 ! muscarinic agonist relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:77746 ! human metabolite [Term] id: CHEBI:15366 name: acetic acid namespace: chebi_ontology alt_id: CHEBI:22169 alt_id: CHEBI:2387 alt_id: CHEBI:40486 def: "A simple monocarboxylic acid containing two carbons." [] subset: 3_STAR synonym: "ACETIC ACID" EXACT [PDBeChem] synonym: "Acetic acid" EXACT [KEGG_COMPOUND] synonym: "acetic acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide acetique" RELATED [ChemIDplus] synonym: "AcOH" RELATED [ChEBI] synonym: "CH3-COOH" RELATED [IUPAC] synonym: "CH3CO2H" RELATED [ChEBI] synonym: "E 260" RELATED [ChEBI] synonym: "E-260" RELATED [ChEBI] synonym: "E260" RELATED [ChEBI] synonym: "Essigsaeure" RELATED [ChEBI] synonym: "Ethanoic acid" RELATED [KEGG_COMPOUND] synonym: "ethoic acid" RELATED [ChEBI] synonym: "Ethylic acid" RELATED [ChemIDplus] synonym: "HOAc" RELATED [ChEBI] synonym: "INS No. 260" RELATED [ChEBI] synonym: "MeCO2H" RELATED [ChEBI] synonym: "MeCOOH" RELATED [ChEBI] synonym: "Methanecarboxylic acid" RELATED [ChemIDplus] xref: Beilstein:506007 {source="Beilstein"} xref: CAS:64-19-7 {source="ChemIDplus"} xref: CAS:64-19-7 {source="NIST Chemistry WebBook"} xref: CAS:64-19-7 {source="KEGG COMPOUND"} xref: Drug_Central:4211 {source="DrugCentral"} xref: Gmelin:1380 {source="Gmelin"} xref: HMDB:HMDB0000042 xref: KEGG:C00033 xref: KEGG:D00010 xref: KNApSAcK:C00001176 xref: LIPID_MAPS_instance:LMFA01010002 {source="LIPID MAPS"} xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PDBeChem:ACY xref: PMID:12005138 {source="Europe PMC"} xref: PMID:15107950 {source="Europe PMC"} xref: PMID:16630552 {source="Europe PMC"} xref: PMID:16774200 {source="Europe PMC"} xref: PMID:17190852 {source="Europe PMC"} xref: PMID:19416101 {source="Europe PMC"} xref: PMID:19469536 {source="Europe PMC"} xref: PMID:22153255 {source="Europe PMC"} xref: PMID:22173419 {source="Europe PMC"} xref: PPDB:1333 xref: Reaxys:506007 {source="Reaxys"} xref: Wikipedia:Acetic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: has_role CHEBI:48356 ! protic solvent relationship: has_role CHEBI:64049 ! food acidity regulator relationship: has_role CHEBI:65256 ! antimicrobial food preservative relationship: has_role CHEBI:83056 ! Daphnia magna metabolite relationship: is_conjugate_acid_of CHEBI:30089 ! acetate [Term] id: CHEBI:15379 name: dioxygen namespace: chebi_ontology alt_id: CHEBI:10745 alt_id: CHEBI:13416 alt_id: CHEBI:23833 alt_id: CHEBI:25366 alt_id: CHEBI:30491 alt_id: CHEBI:44742 alt_id: CHEBI:7860 subset: 3_STAR synonym: "[OO]" RELATED [MolBase] synonym: "dioxygen" EXACT IUPAC_NAME [IUPAC] synonym: "dioxygene" RELATED [ChEBI] synonym: "Disauerstoff" RELATED [ChEBI] synonym: "E 948" RELATED [ChEBI] synonym: "E-948" RELATED [ChEBI] synonym: "E948" RELATED [ChEBI] synonym: "molecular oxygen" RELATED [ChEBI] synonym: "O2" RELATED [UniProt] synonym: "O2" RELATED [IUPAC] synonym: "O2" RELATED [KEGG_COMPOUND] synonym: "Oxygen" RELATED [KEGG_COMPOUND] synonym: "OXYGEN MOLECULE" RELATED [PDBeChem] xref: CAS:7782-44-7 {source="NIST Chemistry WebBook"} xref: CAS:7782-44-7 {source="ChemIDplus"} xref: CAS:7782-44-7 {source="KEGG COMPOUND"} xref: Gmelin:485 {source="Gmelin"} xref: HMDB:HMDB0001377 xref: KEGG:C00007 xref: KEGG:D00003 xref: MetaCyc:OXYGEN-MOLECULE xref: MolBase:750 xref: PDBeChem:OXY xref: PMID:10906528 {source="Europe PMC"} xref: PMID:16977326 {source="Europe PMC"} xref: PMID:18210929 {source="Europe PMC"} xref: PMID:18638417 {source="Europe PMC"} xref: PMID:19840863 {source="Europe PMC"} xref: PMID:7710549 {source="Europe PMC"} xref: PMID:9463773 {source="Europe PMC"} xref: Wikipedia:Oxygen is_a: BFO:0000004 ! independent continuant is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:25362 ! elemental molecule is_a: CHEBI:33263 ! diatomic oxygen relationship: has_role CHEBI:27027 ! micronutrient relationship: has_role CHEBI:33893 ! reagent relationship: has_role CHEBI:35472 ! anti-inflammatory drug relationship: has_role CHEBI:63248 ! oxidising agent relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: has_role CHEBI:77974 ! food packaging gas relationship: is_conjugate_base_of CHEBI:29793 ! hydridodioxygen(1+) [Term] id: CHEBI:15693 name: aldose namespace: chebi_ontology alt_id: CHEBI:13755 alt_id: CHEBI:22305 alt_id: CHEBI:2561 def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." [] subset: 3_STAR synonym: "Aldose" EXACT [KEGG_COMPOUND] synonym: "aldoses" RELATED [ChEBI] synonym: "an aldose" RELATED [UniProt] xref: KEGG:C01370 xref: Wikipedia:Aldose is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:15841 name: polypeptide namespace: chebi_ontology alt_id: CHEBI:14860 alt_id: CHEBI:8314 def: "A peptide containing ten or more amino acid residues." [] subset: 3_STAR synonym: "polipeptido" RELATED [ChEBI] synonym: "Polypeptid" RELATED [ChEBI] synonym: "Polypeptide" EXACT [KEGG_COMPOUND] synonym: "polypeptides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00403 is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:15986 name: polynucleotide namespace: chebi_ontology alt_id: CHEBI:13672 alt_id: CHEBI:14859 alt_id: CHEBI:8312 def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." [] subset: 3_STAR synonym: "Polynucleotide" EXACT [KEGG_COMPOUND] synonym: "polynucleotides" RELATED [ChEBI] xref: KEGG:C00419 is_a: CHEBI:33695 ! information biomacromolecule is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_part CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:16134 name: ammonia namespace: chebi_ontology alt_id: CHEBI:13405 alt_id: CHEBI:13406 alt_id: CHEBI:13407 alt_id: CHEBI:13771 alt_id: CHEBI:22533 alt_id: CHEBI:44269 alt_id: CHEBI:44284 alt_id: CHEBI:44404 alt_id: CHEBI:7434 def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." [] subset: 3_STAR synonym: "[NH3]" RELATED [MolBase] synonym: "AMMONIA" EXACT [PDBeChem] synonym: "Ammonia" EXACT [KEGG_COMPOUND] synonym: "ammonia" EXACT IUPAC_NAME [IUPAC] synonym: "ammoniac" RELATED [ChEBI] synonym: "Ammoniak" RELATED [ChemIDplus] synonym: "amoniaco" RELATED [ChEBI] synonym: "azane" EXACT IUPAC_NAME [IUPAC] synonym: "NH3" RELATED [KEGG_COMPOUND] synonym: "NH3" RELATED [UniProt] synonym: "NH3" RELATED [IUPAC] synonym: "R-717" RELATED [ChEBI] synonym: "spirit of hartshorn" RELATED [ChemIDplus] xref: Beilstein:3587154 {source="Beilstein"} xref: CAS:7664-41-7 {source="ChemIDplus"} xref: CAS:7664-41-7 {source="NIST Chemistry WebBook"} xref: CAS:7664-41-7 {source="KEGG COMPOUND"} xref: Drug_Central:4625 {source="DrugCentral"} xref: Gmelin:79 {source="Gmelin"} xref: HMDB:HMDB0000051 xref: KEGG:C00014 xref: KEGG:D02916 xref: KNApSAcK:C00007267 xref: MetaCyc:AMMONIA xref: MolBase:930 xref: PDBeChem:NH3 xref: PMID:110589 {source="Europe PMC"} xref: PMID:11139349 {source="Europe PMC"} xref: PMID:11540049 {source="Europe PMC"} xref: PMID:11746427 {source="Europe PMC"} xref: PMID:11783653 {source="Europe PMC"} xref: PMID:13753780 {source="Europe PMC"} xref: PMID:14663195 {source="Europe PMC"} xref: PMID:15092448 {source="Europe PMC"} xref: PMID:15094021 {source="Europe PMC"} xref: PMID:15554424 {source="Europe PMC"} xref: PMID:15969015 {source="Europe PMC"} xref: PMID:16008360 {source="Europe PMC"} xref: PMID:16050680 {source="Europe PMC"} xref: PMID:16348008 {source="Europe PMC"} xref: PMID:16349403 {source="Europe PMC"} xref: PMID:16614889 {source="Europe PMC"} xref: PMID:16664306 {source="Europe PMC"} xref: PMID:16842901 {source="Europe PMC"} xref: PMID:17025297 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17569513 {source="Europe PMC"} xref: PMID:17737668 {source="Europe PMC"} xref: PMID:18670398 {source="Europe PMC"} xref: PMID:22002069 {source="Europe PMC"} xref: PMID:22081570 {source="Europe PMC"} xref: PMID:22088435 {source="Europe PMC"} xref: PMID:22100291 {source="Europe PMC"} xref: PMID:22130175 {source="Europe PMC"} xref: PMID:22150211 {source="Europe PMC"} xref: PMID:22240068 {source="Europe PMC"} xref: PMID:22290316 {source="Europe PMC"} xref: PMID:22342082 {source="Europe PMC"} xref: PMID:22385337 {source="Europe PMC"} xref: PMID:22443779 {source="Europe PMC"} xref: PMID:22560242 {source="Europe PMC"} xref: Reaxys:3587154 {source="Reaxys"} xref: Wikipedia:Ammonia is_a: BFO:0000004 ! independent continuant is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:35107 ! azane is_a: CHEBI:37176 ! mononuclear parent hydride relationship: has_role CHEBI:228364 ! NMR chemical shift reference compound relationship: has_role CHEBI:50910 ! neurotoxin relationship: has_role CHEBI:59740 ! nucleophilic reagent relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:77941 ! EC 3.5.1.4 (amidase) inhibitor relationship: has_role CHEBI:78433 ! refrigerant relationship: is_conjugate_acid_of CHEBI:29337 ! azanide relationship: is_conjugate_base_of CHEBI:28938 ! ammonium [Term] id: CHEBI:16189 name: sulfate namespace: chebi_ontology alt_id: CHEBI:15135 alt_id: CHEBI:45687 alt_id: CHEBI:9335 def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." [] subset: 3_STAR synonym: "[SO4](2-)" RELATED [IUPAC] synonym: "SO4(2-)" RELATED [IUPAC] synonym: "Sulfate" EXACT [KEGG_COMPOUND] synonym: "sulfate" EXACT [UniProt] synonym: "sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfate anion(2-)" RELATED [HMDB] synonym: "Sulfate dianion" RELATED [HMDB] synonym: "SULFATE ION" RELATED [PDBeChem] synonym: "Sulfate(2-)" RELATED [HMDB] synonym: "Sulfuric acid ion(2-)" RELATED [HMDB] synonym: "sulphate" RELATED [ChEBI] synonym: "sulphate ion" RELATED [ChEBI] synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3648446 {source="Beilstein"} xref: CAS:14808-79-8 {source="ChemIDplus"} xref: CAS:14808-79-8 {source="NIST Chemistry WebBook"} xref: Gmelin:2120 {source="Gmelin"} xref: HMDB:HMDB0001448 xref: KEGG:C00059 xref: KEGG:D05963 xref: MetaCyc:SULFATE xref: PDBeChem:SO4 xref: PMID:11200094 {source="Europe PMC"} xref: PMID:11452993 {source="Europe PMC"} xref: PMID:11581495 {source="Europe PMC"} xref: PMID:11798107 {source="Europe PMC"} xref: PMID:12166931 {source="Europe PMC"} xref: PMID:12668033 {source="Europe PMC"} xref: PMID:14597181 {source="Europe PMC"} xref: PMID:15093386 {source="Europe PMC"} xref: PMID:15984785 {source="Europe PMC"} xref: PMID:16186560 {source="Europe PMC"} xref: PMID:16345535 {source="Europe PMC"} xref: PMID:16347366 {source="Europe PMC"} xref: PMID:16348007 {source="Europe PMC"} xref: PMID:16483812 {source="Europe PMC"} xref: PMID:16534979 {source="Europe PMC"} xref: PMID:16656509 {source="Europe PMC"} xref: PMID:16742508 {source="Europe PMC"} xref: PMID:16742518 {source="Europe PMC"} xref: PMID:17120760 {source="Europe PMC"} xref: PMID:17420092 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17709180 {source="Europe PMC"} xref: PMID:18398178 {source="Europe PMC"} xref: PMID:18815700 {source="Europe PMC"} xref: PMID:18846414 {source="Europe PMC"} xref: PMID:19047345 {source="Europe PMC"} xref: PMID:19244483 {source="Europe PMC"} xref: PMID:19544990 {source="Europe PMC"} xref: PMID:19628332 {source="Europe PMC"} xref: PMID:19812358 {source="Europe PMC"} xref: PMID:30398859 {source="Europe PMC"} xref: Reaxys:3648446 {source="Reaxys"} xref: Wikipedia:Sulfate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: has_role CHEBI:23357 ! cofactor relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate [Term] id: CHEBI:16336 name: hyaluronic acid namespace: chebi_ontology alt_id: CHEBI:14412 alt_id: CHEBI:24622 alt_id: CHEBI:24623 alt_id: CHEBI:5772 def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." [] subset: 3_STAR synonym: "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n" RELATED [ChEBI] synonym: "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n" RELATED [KEGG_COMPOUND] synonym: "acide hyaluronique" RELATED [ChEBI] synonym: "acido hialuronico" RELATED [ChEBI] synonym: "hyaluronan" RELATED [ChEBI] synonym: "Hyaluronic acid" EXACT [KEGG_COMPOUND] synonym: "Hyaluronsaeure" RELATED [ChEBI] xref: Beilstein:8538277 {source="Beilstein"} xref: CAS:9004-61-9 {source="KEGG COMPOUND"} xref: CAS:9004-61-9 {source="ChemIDplus"} xref: HMDB:HMDB0010366 xref: KEGG:C00518 xref: KEGG:D08043 xref: KEGG:G10505 xref: PMID:11122186 {source="Europe PMC"} xref: PMID:18056362 {source="Europe PMC"} xref: PMID:18290544 {source="Europe PMC"} xref: Reaxys:8187837 {source="Reaxys"} xref: Wikipedia:Hyaluronan is_a: BFO:0000004 ! independent continuant is_a: CHEBI:37395 ! mucopolysaccharide is_a: CHEBI:72813 ! exopolysaccharide relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:132153 ! hyaluronate [Term] id: CHEBI:16541 name: protein polypeptide chain namespace: chebi_ontology alt_id: CHEBI:8526 def: "A naturally occurring polypeptide synthesized at the ribosome." [] subset: 3_STAR synonym: "a protein" RELATED [UniProt] synonym: "polypeptide chain" RELATED [ChEBI] synonym: "Protein" RELATED [KEGG_COMPOUND] synonym: "protein polypeptide chains" RELATED [ChEBI] xref: KEGG:C00017 is_a: CHEBI:15841 ! polypeptide relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue [Term] id: CHEBI:16646 name: carbohydrate namespace: chebi_ontology alt_id: CHEBI:15131 alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] subset: 3_STAR synonym: "a carbohydrate" RELATED [UniProt] synonym: "carbohidrato" RELATED [IUPAC] synonym: "carbohidratos" RELATED [IUPAC] synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC] synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC] synonym: "glucide" RELATED [ChEBI] synonym: "glucides" RELATED [ChEBI] synonym: "glucido" RELATED [ChEBI] synonym: "glucidos" RELATED [ChEBI] synonym: "hydrates de carbone" RELATED [ChEBI] synonym: "Kohlenhydrat" RELATED [ChEBI] synonym: "Kohlenhydrate" RELATED [ChEBI] synonym: "saccharide" RELATED [IUPAC] synonym: "saccharides" RELATED [IUPAC] synonym: "saccharidum" RELATED [ChEBI] xref: Wikipedia:Carbohydrate is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16670 name: peptide namespace: chebi_ontology alt_id: CHEBI:14753 alt_id: CHEBI:25906 alt_id: CHEBI:7990 def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." [] subset: 3_STAR synonym: "Peptid" RELATED [ChEBI] synonym: "Peptide" EXACT [KEGG_COMPOUND] synonym: "peptides" EXACT IUPAC_NAME [IUPAC] synonym: "peptido" RELATED [ChEBI] synonym: "peptidos" RELATED [ChEBI] xref: KEGG:C00012 is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound relationship: has_part CHEBI:33708 ! amino-acid residue relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion [Term] id: CHEBI:166902 name: noradrenaline(1+) namespace: chebi_ontology subset: 2_STAR synonym: "noradrenaline" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:33569 ! noradrenaline [Term] id: CHEBI:167559 name: glycan namespace: chebi_ontology def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." [] subset: 3_STAR synonym: "glycans" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16765 name: tryptamine namespace: chebi_ontology alt_id: CHEBI:15274 alt_id: CHEBI:27161 alt_id: CHEBI:46157 alt_id: CHEBI:9767 def: "An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position." [] subset: 3_STAR synonym: "1H-indole-3-ethanamine" RELATED [NIST_Chemistry_WebBook] synonym: "2-(1H-INDOL-3-YL)ETHANAMINE" RELATED [PDBeChem] synonym: "2-(1H-indol-3-yl)ethanamine" EXACT IUPAC_NAME [IUPAC] synonym: "2-(3-indolyl)ethylamine" RELATED [ChemIDplus] synonym: "3-(2-Aminoethyl)indole" RELATED [KEGG_COMPOUND] synonym: "Tryptamine" EXACT [KEGG_COMPOUND] xref: Beilstein:125513 {source="Beilstein"} xref: CAS:61-54-1 {source="ChemIDplus"} xref: CAS:61-54-1 {source="NIST Chemistry WebBook"} xref: CAS:61-54-1 {source="KEGG COMPOUND"} xref: DrugBank:DB08653 xref: Gmelin:603448 {source="Gmelin"} xref: HMDB:HMDB0000303 xref: KEGG:C00398 xref: KNApSAcK:C00001434 xref: MetaCyc:TRYPTAMINE xref: PDBeChem:TSS xref: PMID:16126914 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:24345948 {source="Europe PMC"} xref: PMID:24558969 {source="Europe PMC"} xref: Reaxys:125513 {source="Reaxys"} xref: Wikipedia:Tryptamine is_a: CHEBI:27162 ! tryptamines is_a: CHEBI:38631 ! aminoalkylindole is_a: CHEBI:38958 ! indole alkaloid is_a: CHEBI:64365 ! aralkylamino compound relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:76924 ! plant metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:57887 ! tryptaminium [Term] id: CHEBI:16990 name: bilirubin IXalpha namespace: chebi_ontology alt_id: CHEBI:13898 alt_id: CHEBI:22870 alt_id: CHEBI:3099 def: "A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." [] subset: 3_STAR synonym: "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid" RELATED [ChemIDplus] synonym: "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" RELATED [ChemIDplus] synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" RELATED [IUPAC] synonym: "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione" RELATED [JCBN] synonym: "Bilirubin" RELATED [KEGG_COMPOUND] synonym: "bilirubin" EXACT IUPAC_NAME [IUPAC] synonym: "bilirubin(Z,Z)" RELATED [ChEBI] synonym: "bilirubin-IXalpha" RELATED [ChEBI] xref: Beilstein:74376 {source="Beilstein"} xref: CAS:635-65-4 {source="KEGG COMPOUND"} xref: CAS:635-65-4 {source="ChemIDplus"} xref: Gmelin:411033 {source="Gmelin"} xref: HMDB:HMDB0000054 xref: KEGG:C00486 xref: KNApSAcK:C00029828 xref: MetaCyc:BILIRUBIN xref: PDBeChem:BLR xref: PMID:12799017 {source="Europe PMC"} xref: PMID:18442622 {source="Europe PMC"} xref: PMID:23763371 {source="Europe PMC"} xref: PMID:23768684 {source="Europe PMC"} xref: PMID:30224965 {source="Europe PMC"} xref: PMID:8605219 {source="Europe PMC"} xref: PMID:9587403 {source="Europe PMC"} xref: Reaxys:74376 {source="Reaxys"} xref: Wikipedia:Bilirubin is_a: CHEBI:35692 ! dicarboxylic acid is_a: CHEBI:36735 ! biladienes relationship: has_part CHEBI:142163 ! 24G7 epitope relationship: has_role CHEBI:22586 ! antioxidant relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:57977 ! bilirubin(2-) [Term] id: CHEBI:16991 name: deoxyribonucleic acid namespace: chebi_ontology alt_id: CHEBI:13302 alt_id: CHEBI:21123 alt_id: CHEBI:33698 alt_id: CHEBI:4291 def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." [] subset: 3_STAR synonym: "(Deoxyribonucleotide)m" RELATED [KEGG_COMPOUND] synonym: "(Deoxyribonucleotide)n" RELATED [KEGG_COMPOUND] synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG_COMPOUND] synonym: "Deoxyribonucleic acid" EXACT [KEGG_COMPOUND] synonym: "deoxyribonucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "deoxyribonucleic acids" RELATED [ChEBI] synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI] synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus] synonym: "DNA" RELATED [UniProt] synonym: "DNA" RELATED [KEGG_COMPOUND] synonym: "DNA" RELATED [IUPAC] synonym: "DNAn" RELATED [KEGG_COMPOUND] synonym: "DNAn+1" RELATED [KEGG_COMPOUND] synonym: "DNS" RELATED [ChEBI] synonym: "thymus nucleic acid" RELATED [ChEBI] xref: CAS:9007-49-2 {source="ChemIDplus"} xref: CAS:9007-49-2 {source="KEGG COMPOUND"} xref: KEGG:C00039 is_a: BFO:0000004 ! independent continuant is_a: CHEBI:33696 ! nucleic acid relationship: has_part CHEBI:33793 ! canonical deoxyribonucleoside residue relationship: has_part CHEBI:50298 ! canonical deoxyribonucleotide residue relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:77746 ! human metabolite [Term] id: CHEBI:17087 name: ketone namespace: chebi_ontology alt_id: CHEBI:13427 alt_id: CHEBI:13646 alt_id: CHEBI:24974 alt_id: CHEBI:6127 alt_id: CHEBI:8742 def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." [] subset: 3_STAR synonym: "a ketone" RELATED [UniProt] synonym: "cetone" RELATED [ChEBI] synonym: "Keton" RELATED [ChEBI] synonym: "Ketone" EXACT [KEGG_COMPOUND] synonym: "ketones" EXACT IUPAC_NAME [IUPAC] synonym: "ketones" RELATED [ChEBI] synonym: "R-CO-R'" RELATED [KEGG_COMPOUND] xref: KEGG:C01450 xref: Wikipedia:Ketone is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:17089 name: glycoprotein namespace: chebi_ontology alt_id: CHEBI:14349 alt_id: CHEBI:5481 alt_id: CHEBI:5493 def: "A compound in which a carbohydrate component is covalently bound to a protein component." [] subset: 3_STAR synonym: "a glycoprotein" RELATED [UniProt] synonym: "glicoproteina" RELATED [ChEBI] synonym: "glicoproteinas" RELATED [ChEBI] synonym: "Glycoprotein" EXACT [KEGG_COMPOUND] synonym: "glycoproteine" RELATED [ChEBI] synonym: "glycoproteines" RELATED [ChEBI] synonym: "glycoproteins" EXACT IUPAC_NAME [IUPAC] synonym: "Glykoprotein" RELATED [ChEBI] synonym: "Glykoproteine" RELATED [ChEBI] xref: KEGG:C00326 is_a: CHEBI:33837 ! conjugated protein is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:17234 name: glucose namespace: chebi_ontology alt_id: CHEBI:14313 alt_id: CHEBI:24277 alt_id: CHEBI:33929 alt_id: CHEBI:5418 def: "An aldohexose used as a source of energy and metabolic intermediate." [] subset: 3_STAR synonym: "DL-glucose" RELATED [ChEBI] synonym: "Glc" RELATED [JCBN] synonym: "gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "Glucose" EXACT [KEGG_COMPOUND] synonym: "glucose" EXACT IUPAC_NAME [IUPAC] synonym: "Glukose" RELATED [ChEBI] xref: CAS:50-99-7 {source="KEGG COMPOUND"} xref: KEGG:C00293 xref: Wikipedia:Glucose is_a: BFO:0000004 ! independent continuant is_a: CHEBI:33917 ! aldohexose relationship: has_role CHEBI:78675 ! fundamental metabolite [Term] id: CHEBI:17544 name: hydrogencarbonate namespace: chebi_ontology alt_id: CHEBI:13363 alt_id: CHEBI:22863 alt_id: CHEBI:40961 alt_id: CHEBI:5589 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." [] subset: 3_STAR synonym: "[CO2(OH)](-)" RELATED [IUPAC] synonym: "Acid carbonate" RELATED [KEGG_COMPOUND] synonym: "Bicarbonate" RELATED [KEGG_COMPOUND] synonym: "BICARBONATE ION" RELATED [PDBeChem] synonym: "HCO3(-)" RELATED [IUPAC] synonym: "HCO3-" RELATED [KEGG_COMPOUND] synonym: "hydrogen carbonate" RELATED [PDBeChem] synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND] synonym: "hydrogencarbonate" EXACT [UniProt] synonym: "hydrogencarbonate" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogencarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3903504 {source="Beilstein"} xref: CAS:71-52-3 {source="ChemIDplus"} xref: Gmelin:49249 {source="Gmelin"} xref: HMDB:HMDB0000595 xref: KEGG:C00288 xref: MetaCyc:HCO3 xref: PDBeChem:BCT xref: PMID:17215880 {source="Europe PMC"} xref: PMID:17505962 {source="Europe PMC"} xref: PMID:18439416 {source="Europe PMC"} xref: PMID:28732801 {source="Europe PMC"} xref: PMID:29150416 {source="Europe PMC"} xref: PMID:29460248 {source="Europe PMC"} xref: PMID:29466234 {source="Europe PMC"} xref: PMID:4208463 {source="Europe PMC"} xref: Wikipedia:Bicarbonate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35604 ! carbon oxoanion relationship: has_role CHEBI:23357 ! cofactor relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:76971 ! Escherichia coli metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid [Term] id: CHEBI:17608 name: D-aldohexose namespace: chebi_ontology alt_id: CHEBI:12990 alt_id: CHEBI:21038 def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] subset: 3_STAR synonym: "D-aldohexoses" RELATED [ChEBI] is_a: CHEBI:33917 ! aldohexose is_a: CHEBI:4194 ! D-hexose [Term] id: CHEBI:17634 name: D-glucose namespace: chebi_ontology alt_id: CHEBI:12965 alt_id: CHEBI:20999 def: "A glucose with D-configuration." [] subset: 3_STAR synonym: "D(+)-glucose" RELATED [ChemIDplus] synonym: "D-(+)-glucose" RELATED [NIST_Chemistry_WebBook] synonym: "D-gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "D-glucose" EXACT IUPAC_NAME [IUPAC] synonym: "dextrose" RELATED [NIST_Chemistry_WebBook] synonym: "grape sugar" RELATED [ChemIDplus] synonym: "Traubenzucker" RELATED [ChemIDplus] xref: CAS:50-99-7 {source="NIST Chemistry WebBook"} xref: CAS:50-99-7 {source="ChemIDplus"} is_a: CHEBI:17234 ! glucose is_a: CHEBI:17608 ! D-aldohexose [Term] id: CHEBI:17891 name: donor namespace: chebi_ontology alt_id: CHEBI:14202 alt_id: CHEBI:4697 def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." [] subset: 3_STAR synonym: "Donator" RELATED [ChEBI] synonym: "donneur" RELATED [ChEBI] synonym: "Donor" EXACT [KEGG_COMPOUND] xref: KEGG:C01351 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:18059 name: lipid namespace: chebi_ontology alt_id: CHEBI:14517 alt_id: CHEBI:25054 alt_id: CHEBI:6486 def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [] subset: 3_STAR synonym: "Lipid" EXACT [KEGG_COMPOUND] synonym: "lipids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C01356 is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:18085 name: glycosaminoglycan namespace: chebi_ontology alt_id: CHEBI:14361 alt_id: CHEBI:24398 alt_id: CHEBI:5495 def: "Any polysaccharide containing a substantial proportion of aminomonosaccharide residues." [] subset: 3_STAR synonym: "glicosaminoglicano" RELATED [IUPAC] synonym: "Glycosaminoglycan" EXACT [KEGG_COMPOUND] synonym: "glycosaminoglycan" EXACT IUPAC_NAME [IUPAC] synonym: "glycosaminoglycane" RELATED [IUPAC] synonym: "glycosaminoglycans" RELATED [ChEBI] synonym: "Glykosaminoglykan" RELATED [ChEBI] xref: KEGG:C02545 xref: Wikipedia:Glycosaminoglycan is_a: CHEBI:22506 ! aminoglycan [Term] id: CHEBI:18133 name: hexose namespace: chebi_ontology alt_id: CHEBI:14399 alt_id: CHEBI:24590 alt_id: CHEBI:5709 def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." [] subset: 3_STAR synonym: "Hexose" EXACT [KEGG_COMPOUND] synonym: "hexoses" RELATED [ChEBI] synonym: "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" RELATED [GlyTouCan] xref: GlyGen:G70994MS xref: GlyTouCan:G70994MS xref: KEGG:C00738 is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:18154 name: polysaccharide namespace: chebi_ontology alt_id: CHEBI:14864 alt_id: CHEBI:26205 alt_id: CHEBI:8322 def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." [] subset: 3_STAR synonym: "Glycan" RELATED [KEGG_COMPOUND] synonym: "Glycane" RELATED [ChEBI] synonym: "glycans" RELATED [IUPAC] synonym: "Glykan" RELATED [ChEBI] synonym: "Glykane" RELATED [ChEBI] synonym: "polisacarido" RELATED [ChEBI] synonym: "polisacaridos" RELATED [IUPAC] synonym: "Polysaccharide" EXACT [KEGG_COMPOUND] synonym: "polysaccharides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00420 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:18282 name: nucleobase namespace: chebi_ontology alt_id: CHEBI:13873 alt_id: CHEBI:25598 alt_id: CHEBI:2995 def: "That part of DNA or RNA that may be involved in pairing." [] subset: 3_STAR synonym: "Base" RELATED [KEGG_COMPOUND] synonym: "nucleobases" RELATED [ChEBI] xref: KEGG:C00701 xref: Wikipedia:Nucleobase is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:18357 name: (R)-noradrenaline namespace: chebi_ontology alt_id: CHEBI:1 alt_id: CHEBI:14668 alt_id: CHEBI:25592 alt_id: CHEBI:258884 alt_id: CHEBI:43725 def: "The R-enantiomer of noradrenaline." [] subset: 3_STAR synonym: "(-)-arterenol" RELATED [ChemIDplus] synonym: "(-)-noradrenaline" RELATED [IUPHAR] synonym: "(-)-norepinephrine" RELATED [ChemIDplus] synonym: "(R)-(-)-norepinephrine" RELATED [ChemIDplus] synonym: "(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol" RELATED [ChemIDplus] synonym: "(R)-norepinephrine" RELATED [ChemIDplus] synonym: "4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol" RELATED [KEGG_COMPOUND] synonym: "4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] synonym: "Arterenol" RELATED [KEGG_COMPOUND] synonym: "L-Noradrenaline" RELATED [KEGG_COMPOUND] synonym: "L-NOREPINEPHRINE" RELATED [PDBeChem] synonym: "Noradrenaline" RELATED [KEGG_COMPOUND] synonym: "norepinefrina" RELATED INN [ChEBI] synonym: "Norepinephrine" RELATED [KEGG_COMPOUND] synonym: "norepinephrine" RELATED INN [ChemIDplus] synonym: "norepinephrine" RELATED INN [WHO_MedNet] synonym: "norepinephrinum" RELATED INN [ChEBI] xref: Beilstein:2804840 {source="Beilstein"} xref: Beilstein:4231961 {source="ChemIDplus"} xref: CAS:51-41-2 {source="ChemIDplus"} xref: CAS:51-41-2 {source="KEGG COMPOUND"} xref: Drug_Central:1960 {source="DrugCentral"} xref: DrugBank:DB00368 xref: HMDB:HMDB0000216 xref: KEGG:C00547 xref: KEGG:D00076 xref: KNApSAcK:C00001424 xref: PDBeChem:LNR xref: Reaxys:2804840 {source="Reaxys"} xref: Wikipedia:Norepinephrine is_a: CHEBI:33569 ! noradrenaline relationship: has_role CHEBI:25512 ! neurotransmitter relationship: has_role CHEBI:35524 ! sympathomimetic agent relationship: has_role CHEBI:35569 ! alpha-adrenergic agonist relationship: has_role CHEBI:50514 ! vasoconstrictor agent relationship: has_role CHEBI:75771 ! mouse metabolite relationship: is_conjugate_base_of CHEBI:72587 ! (R)-noradrenaline(1+) relationship: is_enantiomer_of CHEBI:33571 ! (S)-noradrenaline [Term] id: CHEBI:20664 name: 5beta-cholane namespace: chebi_ontology subset: 3_STAR synonym: "5beta-cholane" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:2048472 {source="Beilstein"} is_a: CHEBI:35519 ! cholane [Term] id: CHEBI:22221 name: acyl group namespace: chebi_ontology def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." [] subset: 3_STAR synonym: "acyl group" EXACT [IUPAC] synonym: "acyl groups" RELATED [ChEBI] synonym: "alkanoyl" EXACT IUPAC_NAME [IUPAC] synonym: "alkanoyl group" RELATED [ChEBI] synonym: "groupe acyle" RELATED [IUPAC] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:22314 name: alkali metal atom namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal" RELATED [ChEBI] synonym: "alkali metals" EXACT IUPAC_NAME [IUPAC] synonym: "Alkalimetall" RELATED [ChEBI] synonym: "Alkalimetalle" RELATED [ChEBI] synonym: "metal alcalin" RELATED [ChEBI] synonym: "metal alcalino" RELATED [ChEBI] synonym: "metales alcalinos" RELATED [ChEBI] synonym: "metaux alcalins" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22315 name: alkaloid namespace: chebi_ontology def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." [] subset: 3_STAR synonym: "alcaloide" RELATED [ChEBI] synonym: "alcaloides" RELATED [ChEBI] synonym: "Alkaloid" EXACT [ChEBI] synonym: "Alkaloide" RELATED [ChEBI] synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Alkaloid is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35352 ! organonitrogen compound relationship: has_role CHEBI:25212 ! metabolite [Term] id: CHEBI:22506 name: aminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycans" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative [Term] id: CHEBI:22563 name: anion namespace: chebi_ontology def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." [] subset: 3_STAR synonym: "Anion" EXACT [ChEBI] synonym: "anion" EXACT IUPAC_NAME [IUPAC] synonym: "anion" EXACT [ChEBI] synonym: "Anionen" RELATED [ChEBI] synonym: "aniones" RELATED [ChEBI] synonym: "anions" RELATED [IUPAC] is_a: CHEBI:24870 ! ion [Term] id: CHEBI:22586 name: antioxidant namespace: chebi_ontology def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." [] subset: 3_STAR synonym: "antioxidants" RELATED [ChEBI] synonym: "antioxydant" RELATED [ChEBI] synonym: "antoxidant" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22695 name: base namespace: chebi_ontology def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." [] subset: 3_STAR synonym: "Base" EXACT [ChEBI] synonym: "base" EXACT [ChEBI] synonym: "base" EXACT IUPAC_NAME [IUPAC] synonym: "Base1" RELATED [KEGG_COMPOUND] synonym: "Base2" RELATED [KEGG_COMPOUND] synonym: "Basen" RELATED [ChEBI] synonym: "bases" RELATED [ChEBI] synonym: "Nucleobase" RELATED [KEGG_COMPOUND] xref: KEGG:C00701 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22728 name: benzopyrrole namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrroles" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:228364 name: NMR chemical shift reference compound namespace: chebi_ontology def: "Any compound that produces a peak used to reference an NMR spectrum during data pre-processing." [] subset: 3_STAR synonym: "NMR chemical shift reference compounds" RELATED [ChEBI] synonym: "NMR chemical shift standard" RELATED [ChEBI] synonym: "NMR chemical shift standards" RELATED [ChEBI] synonym: "NMR internal standard" RELATED [ChEBI] synonym: "NMR internal standards" RELATED [ChEBI] synonym: "NMR reference standard" RELATED [ChEBI] synonym: "NMR reference standards" RELATED [ChEBI] is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22868 name: bile salt namespace: chebi_ontology def: "A sodium salt of the conjugate of any bile acid with either glycine or taurine." [] subset: 3_STAR synonym: "Bile acid" RELATED [KEGG_COMPOUND] synonym: "bile salts" RELATED [ChEBI] xref: KEGG:C01558 is_a: CHEBI:36078 ! cholanoid is_a: CHEBI:38700 ! organic sodium salt [Term] id: CHEBI:23004 name: carbamoyl group namespace: chebi_ontology def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." [] subset: 3_STAR synonym: "-C(O)NH2" RELATED [ChEBI] synonym: "-CONH2" RELATED [IUPAC] synonym: "aminocarbonyl" RELATED [IUPAC] synonym: "carbamoyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbamyl" RELATED [ChEBI] synonym: "carbamyl group" RELATED [ChEBI] synonym: "carboxamide" RELATED [IUPAC] xref: PMID:24168430 {source="Europe PMC"} is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid [Term] id: CHEBI:23019 name: carbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=O" RELATED [IUPAC] synonym: "carbonyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbonyl group" EXACT [UniProt] synonym: "carbonyl group" EXACT [ChEBI] is_a: CHEBI:51422 ! organodiyl group [Term] id: CHEBI:23357 name: cofactor namespace: chebi_ontology def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." [] subset: 3_STAR synonym: "cofactor" EXACT [IUPAC] synonym: "cofactors" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Cofactor_(biochemistry) is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] subset: 3_STAR synonym: "entidad molecular" RELATED [IUPAC] synonym: "entidades moleculares" RELATED [IUPAC] synonym: "entite moleculaire" RELATED [IUPAC] synonym: "molecular entities" RELATED [IUPAC] synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "molekulare Entitaet" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:23449 name: cyclic peptide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic peptides" RELATED [ChEBI] synonym: "Cyclopeptid" RELATED [ChEBI] synonym: "peptide cyclique" RELATED [IUPAC] synonym: "peptido ciclico" RELATED [IUPAC] synonym: "Zyklopeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23888 name: drug namespace: chebi_ontology def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." [] subset: 3_STAR synonym: "drugs" RELATED [ChEBI] synonym: "medicine" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:23906 name: monoatomic cation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic cations" RELATED [ChEBI] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:23924 name: enzyme inhibitor namespace: chebi_ontology def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." [] subset: 3_STAR synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "enzyme inhibitors" RELATED [ChEBI] synonym: "inhibidor enzimatico" RELATED [ChEBI] synonym: "inhibidores enzimaticos" RELATED [ChEBI] synonym: "inhibiteur enzymatique" RELATED [ChEBI] synonym: "inhibiteurs enzymatiques" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:24384 name: glycogens namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:37163 ! glucan [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] [Term] id: CHEBI:24432 name: biological role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a biological context." [] subset: 3_STAR synonym: "biological function" RELATED [ChEBI] is_a: CHEBI:50906 ! role [Term] id: CHEBI:24433 name: group namespace: chebi_ontology def: "A defined linked collection of atoms or a single atom within a molecular entity." [] subset: 3_STAR synonym: "group" EXACT IUPAC_NAME [IUPAC] synonym: "groupe" RELATED [IUPAC] synonym: "grupo" RELATED [IUPAC] synonym: "grupos" RELATED [IUPAC] synonym: "Gruppe" RELATED [ChEBI] synonym: "Rest" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:33250 ! atom [Term] id: CHEBI:24532 name: organic heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." [] subset: 3_STAR synonym: "organic heterocycle" RELATED [ChEBI] synonym: "organic heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:24533 name: heterodetic cyclic peptide namespace: chebi_ontology def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." [] subset: 3_STAR synonym: "heterodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC] synonym: "heterodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique heterodetique" RELATED [IUPAC] synonym: "peptido ciclico heterodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24621 name: hormone namespace: chebi_ontology def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." [] subset: 3_STAR synonym: "endocrine" RELATED [ChEBI] synonym: "hormones" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] subset: 3_STAR is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:43176 ! hydroxy group [Term] id: CHEBI:24663 name: hydroxy-5beta-cholanic acid namespace: chebi_ontology def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." [] subset: 3_STAR synonym: "hydroxy-5beta-cholanic acids" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:36248 ! 5beta-cholanic acids relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid [Term] id: CHEBI:24828 name: indoles namespace: chebi_ontology def: "Any compound containing an indole skeleton." [] subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24833 name: oxoacid namespace: chebi_ontology def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "oxacids" RELATED [ChEBI] synonym: "oxiacids" RELATED [ChEBI] synonym: "oxo acid" RELATED [ChEBI] synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC] synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC] synonym: "oxy-acids" RELATED [ChEBI] synonym: "oxyacids" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24651 ! hydroxides relationship: has_role CHEBI:39141 ! Bronsted acid [Term] id: CHEBI:24834 name: inorganic anion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36914 ! inorganic ion [Term] id: CHEBI:24835 name: inorganic molecular entity namespace: chebi_ontology def: "A molecular entity that contains no carbon." [] subset: 3_STAR synonym: "anorganische Verbindungen" RELATED [ChEBI] synonym: "inorganic compounds" RELATED [ChEBI] synonym: "inorganic entity" RELATED [ChEBI] synonym: "inorganic molecular entities" RELATED [ChEBI] synonym: "inorganics" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24836 name: inorganic oxide namespace: chebi_ontology subset: 3_STAR synonym: "inorganic oxides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide [Term] id: CHEBI:24866 name: salt namespace: chebi_ontology def: "A salt is an assembly of cations and anions." [] subset: 3_STAR synonym: "ionic compound" RELATED [ChEBI] synonym: "ionic compounds" RELATED [ChEBI] synonym: "sal" RELATED [ChEBI] synonym: "sales" RELATED [ChEBI] synonym: "salt" EXACT IUPAC_NAME [IUPAC] synonym: "salts" RELATED [ChEBI] synonym: "Salz" RELATED [ChEBI] synonym: "Salze" RELATED [ChEBI] synonym: "sel" RELATED [ChEBI] synonym: "sels" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:22563 ! anion relationship: has_part CHEBI:36916 ! cation [Term] id: CHEBI:24867 name: monoatomic ion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:24868 name: organic salt namespace: chebi_ontology subset: 3_STAR synonym: "organic salts" RELATED [ChEBI] synonym: "organisches Salz" RELATED [ChEBI] is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24870 name: ion namespace: chebi_ontology def: "A molecular entity having a net electric charge." [] subset: 3_STAR synonym: "Ion" EXACT [ChEBI] synonym: "ion" EXACT IUPAC_NAME [IUPAC] synonym: "ion" EXACT [ChEBI] synonym: "Ionen" RELATED [ChEBI] synonym: "iones" RELATED [ChEBI] synonym: "ions" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:25046 name: linear tetrapyrrole namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26932 ! tetrapyrrole [Term] id: CHEBI:25212 name: metabolite namespace: chebi_ontology alt_id: CHEBI:26619 alt_id: CHEBI:35220 def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." [] subset: 3_STAR synonym: "metabolite" EXACT IUPAC_NAME [IUPAC] synonym: "metabolites" RELATED [ChEBI] synonym: "primary metabolites" RELATED [ChEBI] synonym: "secondary metabolites" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:25213 name: metal cation namespace: chebi_ontology subset: 3_STAR synonym: "a metal cation" RELATED [UniProt] synonym: "metal cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:25362 name: elemental molecule namespace: chebi_ontology def: "A molecule all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic molecule" RELATED [ChEBI] synonym: "homoatomic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:25367 name: molecule namespace: chebi_ontology def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." [] subset: 3_STAR synonym: "molecula" RELATED [IUPAC] synonym: "molecule" EXACT [IUPAC] synonym: "molecules" RELATED [IUPAC] synonym: "Molekuel" RELATED [ChEBI] synonym: "neutral molecular compounds" RELATED [IUPAC] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25375 name: monoamine molecular messenger namespace: chebi_ontology def: "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [] subset: 3_STAR synonym: "monamines" RELATED [ChEBI] synonym: "monoamines" RELATED [ChEBI] is_a: CHEBI:63534 ! monoamine relationship: has_role CHEBI:33280 ! molecular messenger [Term] id: CHEBI:25384 name: monocarboxylic acid namespace: chebi_ontology def: "An oxoacid containing a single carboxy group." [] subset: 3_STAR synonym: "monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion [Term] id: CHEBI:25414 name: monoatomic monocation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monocations" RELATED [ChEBI] synonym: "monovalent inorganic cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:25512 name: neurotransmitter namespace: chebi_ontology def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." [] subset: 3_STAR synonym: "neurotransmitters" RELATED [ChEBI] xref: Wikipedia:Neurotransmitter is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:25555 name: nitrogen atom namespace: chebi_ontology subset: 3_STAR synonym: "7N" RELATED [IUPAC] synonym: "azote" RELATED [IUPAC] synonym: "N" RELATED [IUPAC] synonym: "nitrogen" EXACT IUPAC_NAME [IUPAC] synonym: "nitrogen" RELATED [ChEBI] synonym: "nitrogeno" RELATED [ChEBI] synonym: "Stickstoff" RELATED [ChEBI] xref: WebElements:N is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: has_role CHEBI:33937 ! macronutrient [Term] id: CHEBI:25585 name: nonmetal atom namespace: chebi_ontology subset: 3_STAR synonym: "Nichtmetall" RELATED [ChEBI] synonym: "Nichtmetalle" RELATED [ChEBI] synonym: "no metal" RELATED [ChEBI] synonym: "no metales" RELATED [ChEBI] synonym: "non-metal" RELATED [ChEBI] synonym: "non-metaux" RELATED [ChEBI] synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC] synonym: "nonmetal" RELATED [ChEBI] synonym: "nonmetals" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:25696 name: organic anion namespace: chebi_ontology def: "Any organic ion with a net negative charge." [] subset: 3_STAR synonym: "organic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion [Term] id: CHEBI:25697 name: organic cation namespace: chebi_ontology def: "Any organic ion with a net positive charge." [] subset: 3_STAR synonym: "organic cations" RELATED [ChEBI] is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:25699 name: organic ion namespace: chebi_ontology subset: 3_STAR synonym: "organic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:25704 name: organic sulfate namespace: chebi_ontology def: "Compounds of the general formula SO3HOR where R is an organyl group" [] subset: 3_STAR synonym: "organic sulfates" RELATED [ChEBI] is_a: CHEBI:26820 ! sulfates relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion [Term] id: CHEBI:25741 name: oxide namespace: chebi_ontology def: "An oxide is a chemical compound of oxygen with other chemical elements." [] subset: 3_STAR synonym: "oxide" EXACT [ChEBI] synonym: "oxides" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25805 name: oxygen atom namespace: chebi_ontology subset: 3_STAR synonym: "8O" RELATED [IUPAC] synonym: "O" RELATED [IUPAC] synonym: "oxigeno" RELATED [ChEBI] synonym: "oxygen" EXACT IUPAC_NAME [IUPAC] synonym: "oxygen" RELATED [ChEBI] synonym: "oxygene" RELATED [ChEBI] synonym: "Sauerstoff" RELATED [ChEBI] xref: KEGG:C00007 xref: WebElements:O is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: has_role CHEBI:33937 ! macronutrient [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "oxygen molecular entities" RELATED [ChEBI] synonym: "oxygen molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:25805 ! oxygen atom [Term] id: CHEBI:25905 name: peptide hormone namespace: chebi_ontology def: "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." [] subset: 3_STAR synonym: "peptide hormones" RELATED [ChEBI] synonym: "polypeptide hormone" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide relationship: has_role CHEBI:24621 ! hormone [Term] id: CHEBI:26708 name: sodium atom namespace: chebi_ontology subset: 3_STAR synonym: "11Na" RELATED [IUPAC] synonym: "Na" RELATED [IUPAC] synonym: "Natrium" RELATED [ChemIDplus] synonym: "natrium" RELATED [IUPAC] synonym: "sodio" RELATED [ChemIDplus] synonym: "sodium" EXACT IUPAC_NAME [IUPAC] synonym: "sodium" RELATED [ChEBI] xref: CAS:7440-23-5 {source="ChemIDplus"} xref: Gmelin:16221 {source="Gmelin"} xref: KEGG:C01330 xref: WebElements:Na is_a: BFO:0000004 ! independent continuant is_a: CHEBI:22314 ! alkali metal atom relationship: has_role CHEBI:33937 ! macronutrient relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite [Term] id: CHEBI:26712 name: sodium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sodium compounds" RELATED [ChEBI] synonym: "sodium molecular entities" RELATED [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: has_part CHEBI:26708 ! sodium atom [Term] id: CHEBI:26714 name: sodium salt namespace: chebi_ontology def: "Any alkali metal salt having sodium(1+) as the cation." [] subset: 3_STAR synonym: "Natriumsalz" RELATED [ChEBI] synonym: "Natriumsalze" RELATED [ChEBI] synonym: "sodium salts" RELATED [ChEBI] is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: has_part CHEBI:29101 ! sodium(1+) [Term] id: CHEBI:26764 name: steroid hormone namespace: chebi_ontology def: "Any steroid that acts as hormone." [] subset: 3_STAR synonym: "hormona esteroide" RELATED [ChEBI] synonym: "hormonas esteroideas" RELATED [ChEBI] synonym: "hormone steroide" RELATED [ChEBI] synonym: "hormones steroides" RELATED [ChEBI] synonym: "steroid hormones" RELATED [ChEBI] synonym: "Steroidhormon" RELATED [ChEBI] synonym: "Steroidhormone" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35341 ! steroid relationship: has_role CHEBI:24621 ! hormone [Term] id: CHEBI:26819 name: sulfuric ester namespace: chebi_ontology def: "An ester of an alcohol and sulfuric acid." [] subset: 3_STAR synonym: "sulfate ester" RELATED [ChEBI] synonym: "sulfuric acid ester" RELATED [ChEBI] synonym: "sulfuric acid esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26820 name: sulfates namespace: chebi_ontology def: "Salts and esters of sulfuric acid" [] subset: 3_STAR synonym: "sulfates" EXACT [ChEBI] synonym: "sulfuric acid derivative" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26833 name: sulfur atom namespace: chebi_ontology subset: 3_STAR synonym: "16S" RELATED [IUPAC] synonym: "azufre" RELATED [ChEBI] synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND] synonym: "S" RELATED [IUPAC] synonym: "S" RELATED [KEGG_COMPOUND] synonym: "Schwefel" RELATED [ChEBI] synonym: "soufre" RELATED [ChEBI] synonym: "sulfur" EXACT IUPAC_NAME [IUPAC] synonym: "sulfur" RELATED [ChEBI] synonym: "sulfur" RELATED [UniProt] synonym: "sulphur" RELATED [ChEBI] synonym: "theion" RELATED [IUPAC] xref: CAS:7704-34-9 {source="ChemIDplus"} xref: CAS:7704-34-9 {source="NIST Chemistry WebBook"} xref: KEGG:C00087 xref: KEGG:D06527 xref: PPDB:605 xref: WebElements:S is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: has_role CHEBI:33937 ! macronutrient [Term] id: CHEBI:26835 name: sulfur molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sulfur molecular entities" RELATED [ChEBI] synonym: "sulfur molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:26833 ! sulfur atom [Term] id: CHEBI:26836 name: sulfuric acid namespace: chebi_ontology def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." [] subset: 3_STAR synonym: "[S(OH)2O2]" RELATED [MolBase] synonym: "[SO2(OH)2]" RELATED [IUPAC] synonym: "Acide sulfurique" RELATED [ChemIDplus] synonym: "Acido sulfurico" RELATED [ChemIDplus] synonym: "Acidum sulfuricum" RELATED [ChemIDplus] synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "H2SO4" RELATED [IUPAC] synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus] synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND] synonym: "sulfuric acid" EXACT IUPAC_NAME [IUPAC] synonym: "sulfuric acid" EXACT [ChEBI] synonym: "sulphuric acid" RELATED [MolBase] synonym: "tetraoxosulfuric acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:7664-93-9 {source="ChemIDplus"} xref: CAS:7664-93-9 {source="KEGG COMPOUND"} xref: CAS:7664-93-9 {source="NIST Chemistry WebBook"} xref: Gmelin:2122 {source="Gmelin"} xref: KEGG:C00059 xref: KEGG:D05963 xref: KNApSAcK:C00007530 xref: MolBase:4 xref: PMID:13568755 {source="Europe PMC"} xref: PMID:16122922 {source="Europe PMC"} xref: PMID:19397353 {source="Europe PMC"} xref: PMID:22047659 {source="Europe PMC"} xref: PMID:22136045 {source="Europe PMC"} xref: PMID:22204399 {source="Europe PMC"} xref: PMID:22267186 {source="Europe PMC"} xref: PMID:22296037 {source="Europe PMC"} xref: PMID:22364556 {source="Europe PMC"} xref: PMID:22435616 {source="Europe PMC"} xref: PPDB:606 xref: Reaxys:2037554 {source="Reaxys"} xref: Wikipedia:Sulfuric_acid is_a: CHEBI:33402 ! sulfur oxoacid relationship: has_role CHEBI:35223 ! catalyst relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate [Term] id: CHEBI:26932 name: tetrapyrrole namespace: chebi_ontology def: "A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [] subset: 3_STAR synonym: "a tetrapyrrole" RELATED [UniProt] synonym: "tetrapyrrole" EXACT IUPAC_NAME [IUPAC] synonym: "tetrapyrroles" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38077 ! polypyrrole [Term] id: CHEBI:27027 name: micronutrient namespace: chebi_ontology def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." [] subset: 3_STAR synonym: "micronutrients" RELATED [ChEBI] synonym: "trace elements" RELATED [ChEBI] xref: Wikipedia:Micronutrient is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:27162 name: tryptamines namespace: chebi_ontology def: "Tryptamine and its substitution derivatives." [] subset: 3_STAR is_a: CHEBI:24828 ! indoles [Term] id: CHEBI:27171 name: organic heterobicyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterobicyclic compounds" RELATED [ChEBI] synonym: "organic heterobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33672 ! heterobicyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:27207 name: univalent carboacyl group namespace: chebi_ontology def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "univalent acyl group" RELATED [ChEBI] synonym: "univalent carboacyl groups" RELATED [ChEBI] synonym: "univalent carboxylic acyl groups" RELATED [ChEBI] is_a: CHEBI:37838 ! carboacyl group [Term] id: CHEBI:27369 name: zwitterion namespace: chebi_ontology def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." [] subset: 3_STAR synonym: "compose zwitterionique" RELATED [IUPAC] synonym: "compuestos zwitterionicos" RELATED [IUPAC] synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC] synonym: "zwitteriones" RELATED [IUPAC] synonym: "zwitterionic compounds" RELATED [IUPAC] synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51151 ! dipolar compound [Term] id: CHEBI:27594 name: carbon atom namespace: chebi_ontology alt_id: CHEBI:23009 alt_id: CHEBI:3399 subset: 3_STAR synonym: "6C" RELATED [IUPAC] synonym: "C" RELATED [KEGG_COMPOUND] synonym: "C" RELATED [IUPAC] synonym: "Carbon" RELATED [KEGG_COMPOUND] synonym: "carbon" EXACT IUPAC_NAME [IUPAC] synonym: "carbon" RELATED [ChEBI] synonym: "carbone" RELATED [ChEBI] synonym: "carbonium" RELATED [ChEBI] synonym: "carbono" RELATED [ChEBI] synonym: "Kohlenstoff" RELATED [ChEBI] xref: CAS:7440-44-0 {source="KEGG COMPOUND"} xref: CAS:7440-44-0 {source="ChemIDplus"} xref: KEGG:C06265 xref: WebElements:C is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33306 ! carbon group element atom relationship: has_role CHEBI:33937 ! macronutrient [Term] id: CHEBI:28087 name: glycogen namespace: chebi_ontology alt_id: CHEBI:24379 alt_id: CHEBI:5466 def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." [] subset: 3_STAR synonym: "animal starch" RELATED [ChemIDplus] synonym: "Glycogen" EXACT [KEGG_COMPOUND] synonym: "liver starch" RELATED [ChemIDplus] synonym: "WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1" RELATED [GlyTouCan] xref: CAS:9005-79-2 {source="KEGG COMPOUND"} xref: CAS:9005-79-2 {source="ChemIDplus"} xref: GlyGen:G99991IU xref: GlyTouCan:G99991IU xref: HMDB:HMDB0000757 xref: KEGG:C00182 xref: MetaCyc:CPD0-971 xref: Wikipedia:Glycogen is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24384 ! glycogens relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:76971 ! Escherichia coli metabolite [Term] id: CHEBI:28616 name: carbamic acid namespace: chebi_ontology alt_id: CHEBI:22504 alt_id: CHEBI:23002 alt_id: CHEBI:3386 alt_id: CHEBI:44573 def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." [] subset: 3_STAR synonym: "Aminoameisensaeure" RELATED [ChEBI] synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND] synonym: "Carbamate" RELATED [KEGG_COMPOUND] synonym: "CARBAMIC ACID" EXACT [PDBeChem] synonym: "Carbamic acid" EXACT [KEGG_COMPOUND] synonym: "carbamic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Carbamidsaeure" RELATED [ChEBI] xref: Beilstein:1734754 {source="Beilstein"} xref: CAS:463-77-4 {source="KEGG COMPOUND"} xref: CAS:463-77-4 {source="ChemIDplus"} xref: DrugBank:DB04261 xref: Gmelin:130345 {source="Gmelin"} xref: KEGG:C01563 xref: PDBeChem:OUT xref: Wikipedia:Carbamic_acid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:64708 ! one-carbon compound relationship: has_role CHEBI:76971 ! Escherichia coli metabolite relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate [Term] id: CHEBI:28790 name: serotonin namespace: chebi_ontology alt_id: CHEBI:1420 alt_id: CHEBI:26652 alt_id: CHEBI:49894 def: "A primary amino compound that is the 5-hydroxy derivative of tryptamine." [] subset: 3_STAR synonym: "3-(2-Aminoethyl)-1H-indol-5-ol" RELATED [KEGG_COMPOUND] synonym: "3-(2-aminoethyl)-1H-indol-5-ol" EXACT IUPAC_NAME [IUPAC] synonym: "5-HT" RELATED [IUPHAR] synonym: "5-Hydroxytryptamine" RELATED [KEGG_COMPOUND] synonym: "Enteramine" RELATED [KEGG_COMPOUND] synonym: "SEROTONIN" EXACT [PDBeChem] synonym: "Serotonin" EXACT [KEGG_COMPOUND] synonym: "serotonine" RELATED [ChEBI] synonym: "thrombocytin" RELATED [ChemIDplus] synonym: "thrombotonin" RELATED [ChemIDplus] xref: Beilstein:143524 {source="Beilstein"} xref: CAS:50-67-9 {source="KEGG COMPOUND"} xref: CAS:50-67-9 {source="ChemIDplus"} xref: Gmelin:1861995 {source="Gmelin"} xref: HMDB:HMDB0000259 xref: KEGG:C00780 xref: KNApSAcK:C00001429 xref: LINCS:LSM-6589 xref: MetaCyc:SEROTONIN xref: PDBeChem:SRO xref: PMID:18593914 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:24136337 {source="Europe PMC"} xref: Reaxys:143524 {source="Reaxys"} xref: Wikipedia:Serotonin is_a: CHEBI:25375 ! monoamine molecular messenger is_a: CHEBI:27162 ! tryptamines is_a: CHEBI:33853 ! phenols is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:84729 ! hydroxyindoles relationship: has_functional_parent CHEBI:16765 ! tryptamine relationship: has_role CHEBI:25512 ! neurotransmitter relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:350546 ! serotonin(1+) [Term] id: CHEBI:28938 name: ammonium namespace: chebi_ontology alt_id: CHEBI:22534 alt_id: CHEBI:49783 alt_id: CHEBI:7435 def: "An onium cation obtained by protonation of ammonia." [] subset: 3_STAR synonym: "[NH4](+)" RELATED [MolBase] synonym: "ammonium" EXACT [ChEBI] synonym: "ammonium" EXACT IUPAC_NAME [IUPAC] synonym: "ammonium cation" RELATED [ChemIDplus] synonym: "ammonium ion" RELATED [PDBeChem] synonym: "Ammonium(1+)" RELATED [ChemIDplus] synonym: "azanium" EXACT IUPAC_NAME [IUPAC] synonym: "NH4(+)" RELATED [UniProt] synonym: "NH4(+)" RELATED [IUPAC] synonym: "NH4+" RELATED [KEGG_COMPOUND] xref: CAS:14798-03-9 {source="NIST Chemistry WebBook"} xref: CAS:14798-03-9 {source="ChemIDplus"} xref: Gmelin:84 {source="Gmelin"} xref: KEGG:C01342 xref: MetaCyc:AMMONIUM xref: MolBase:929 xref: PDBeChem:NH4 xref: PMID:11319011 {source="Europe PMC"} xref: PMID:11341317 {source="Europe PMC"} xref: PMID:12096804 {source="Europe PMC"} xref: PMID:14512268 {source="Europe PMC"} xref: PMID:14879753 {source="Europe PMC"} xref: PMID:16345391 {source="Europe PMC"} xref: PMID:16903292 {source="Europe PMC"} xref: PMID:17392693 {source="Europe PMC"} xref: PMID:18515490 {source="Europe PMC"} xref: PMID:19199063 {source="Europe PMC"} xref: PMID:19596600 {source="Europe PMC"} xref: PMID:19682559 {source="Europe PMC"} xref: PMID:19716251 {source="Europe PMC"} xref: PMID:21993530 {source="Europe PMC"} xref: PMID:22265469 {source="Europe PMC"} xref: PMID:22524020 {source="Europe PMC"} xref: PMID:22562341 {source="Europe PMC"} xref: PMID:22631217 {source="Europe PMC"} xref: Reaxys:16093784 {source="Reaxys"} xref: Wikipedia:Ammonium is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:50313 ! onium cation is_a: CHEBI:60242 ! monovalent inorganic cation relationship: has_role CHEBI:23357 ! cofactor relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:76971 ! Escherichia coli metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia [Term] id: CHEBI:28965 name: dicarboxylic acid dianion namespace: chebi_ontology alt_id: CHEBI:13632 alt_id: CHEBI:23688 alt_id: CHEBI:23689 alt_id: CHEBI:38711 def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." [] subset: 3_STAR synonym: "a dicarboxylate" RELATED [UniProt] synonym: "dicarboxylate" RELATED [ChEBI] synonym: "dicarboxylates" RELATED [ChEBI] synonym: "dicarboxylic acid dianion" EXACT [ChEBI] synonym: "dicarboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion is_a: CHEBI:38716 ! carboxylic acid dianion [Term] id: CHEBI:28976 name: carbonic acid namespace: chebi_ontology alt_id: CHEBI:13351 alt_id: CHEBI:23017 alt_id: CHEBI:23744 alt_id: CHEBI:3401 subset: 3_STAR synonym: "[CO(OH)2]" RELATED [IUPAC] synonym: "Carbonic acid" EXACT [KEGG_COMPOUND] synonym: "carbonic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND] synonym: "dihydroxidooxidocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "H2CO3" RELATED [KEGG_COMPOUND] synonym: "H2CO3" RELATED [IUPAC] synonym: "Koehlensaeure" RELATED [ChEBI] xref: CAS:463-79-6 {source="ChemIDplus"} xref: CAS:463-79-6 {source="KEGG COMPOUND"} xref: Gmelin:25554 {source="Gmelin"} xref: KEGG:C01353 xref: PDBeChem:CO3 is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36961 ! chalcocarbonic acid relationship: has_role CHEBI:75771 ! mouse metabolite relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate [Term] id: CHEBI:29067 name: carboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13626 alt_id: CHEBI:13945 alt_id: CHEBI:23026 alt_id: CHEBI:58657 def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a carboxylate" RELATED [UniProt] synonym: "carboxylic acid anions" RELATED [ChEBI] synonym: "carboxylic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:29101 name: sodium(1+) namespace: chebi_ontology alt_id: CHEBI:26717 alt_id: CHEBI:49766 alt_id: CHEBI:9175 def: "A monoatomic monocation obtained from sodium." [] subset: 3_STAR synonym: "Na(+)" RELATED [UniProt] synonym: "Na(+)" RELATED [IUPAC] synonym: "Na+" RELATED [KEGG_COMPOUND] synonym: "sodium cation" EXACT IUPAC_NAME [IUPAC] synonym: "SODIUM ION" RELATED [PDBeChem] synonym: "sodium(1+)" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(1+) ion" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(I) cation" EXACT IUPAC_NAME [IUPAC] xref: CAS:17341-25-2 {source="ChemIDplus"} xref: CAS:17341-25-2 {source="NIST Chemistry WebBook"} xref: Gmelin:15196 {source="Gmelin"} xref: KEGG:C01330 xref: PDBeChem:NA is_a: BFO:0000004 ! independent continuant is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37246 ! elemental sodium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: has_role CHEBI:23357 ! cofactor relationship: has_role CHEBI:77746 ! human metabolite [Term] id: CHEBI:29337 name: azanide namespace: chebi_ontology subset: 3_STAR synonym: "amide" EXACT IUPAC_NAME [IUPAC] synonym: "azanide" EXACT IUPAC_NAME [IUPAC] synonym: "dihydridonitrate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "NH2(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-) relationship: is_conjugate_base_of CHEBI:16134 ! ammonia [Term] id: CHEBI:29340 name: hydridonitrate(2-) namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." [] subset: 3_STAR synonym: "azanediide" EXACT IUPAC_NAME [IUPAC] synonym: "hydridonitrate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "imide" RELATED [IUPAC] synonym: "NH(2-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29337 ! azanide [Term] id: CHEBI:29793 name: hydridodioxygen(1+) namespace: chebi_ontology subset: 3_STAR synonym: "[HO2](+)" RELATED [ChEBI] synonym: "dioxidenium" EXACT IUPAC_NAME [IUPAC] synonym: "HO2(+)" RELATED [IUPAC] synonym: "HOO(+)" RELATED [ChEBI] synonym: "hydridodioxygen(1+)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:508 {source="Gmelin"} is_a: CHEBI:33693 ! oxygen hydride relationship: is_conjugate_acid_of CHEBI:15379 ! dioxygen [Term] id: CHEBI:30089 name: acetate namespace: chebi_ontology alt_id: CHEBI:13704 alt_id: CHEBI:22165 alt_id: CHEBI:40480 def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." [] subset: 3_STAR synonym: "acetate" EXACT [UniProt] synonym: "acetate" EXACT IUPAC_NAME [IUPAC] synonym: "ACETATE ION" RELATED [PDBeChem] synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Azetat" RELATED [ChEBI] synonym: "CH3-COO(-)" RELATED [IUPAC] synonym: "Ethanoat" RELATED [ChEBI] synonym: "ethanoate" RELATED [ChEBI] synonym: "MeCO2 anion" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1901470 {source="Beilstein"} xref: CAS:71-50-1 {source="ChemIDplus"} xref: CAS:71-50-1 {source="NIST Chemistry WebBook"} xref: DrugBank:DB03166 xref: Gmelin:1379 {source="Gmelin"} xref: KEGG:C00033 xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PMID:17190852 {source="Europe PMC"} xref: PMID:22211106 {source="Europe PMC"} xref: PMID:22371380 {source="Europe PMC"} xref: Reaxys:1901470 {source="Reaxys"} xref: UM-BBD_compID:c0050 {source="UM-BBD"} xref: Wikipedia:Acetate is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid [Term] id: CHEBI:30212 name: photon namespace: chebi_ontology alt_id: CHEBI:10581 alt_id: CHEBI:14383 def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force." [] subset: 3_STAR synonym: "foton" RELATED [ChEBI] synonym: "gamma" RELATED [IUPAC] synonym: "hnu" RELATED [IUPAC] synonym: "hnu" RELATED [UniProt] synonym: "Lichtquant" RELATED [ChEBI] synonym: "Light" RELATED [KEGG_COMPOUND] synonym: "light quantum" RELATED [ChEBI] synonym: "photon" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00205 is_a: CHEBI:36341 ! boson [Term] id: CHEBI:3098 name: bile acid namespace: chebi_ontology def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." [] subset: 3_STAR synonym: "5beta-bile acid" RELATED [ChEBI] synonym: "5beta-bile acids" RELATED [ChEBI] synonym: "Bile acid" EXACT [KEGG_COMPOUND] synonym: "bile acids" RELATED [ChEBI] synonym: "Bile salt" RELATED [KEGG_COMPOUND] synonym: "Gallensaeure" RELATED [ChEBI] synonym: "Gallensaeuren" RELATED [ChEBI] xref: KEGG:C01558 is_a: CHEBI:138366 ! bile acids is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid [Term] id: CHEBI:32952 name: amine namespace: chebi_ontology alt_id: CHEBI:13814 alt_id: CHEBI:22474 alt_id: CHEBI:2641 def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "Amin" RELATED [ChEBI] synonym: "Amine" EXACT [KEGG_COMPOUND] synonym: "amines" EXACT IUPAC_NAME [IUPAC] synonym: "Substituted amine" RELATED [KEGG_COMPOUND] xref: KEGG:C00706 is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:32988 name: amide namespace: chebi_ontology alt_id: CHEBI:22473 alt_id: CHEBI:2633 def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "Amide" EXACT [KEGG_COMPOUND] synonym: "amides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00241 is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33232 name: application namespace: chebi_ontology def: "Intended use of the molecular entity or part thereof by humans." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:33233 name: fundamental particle namespace: chebi_ontology def: "A particle not known to have substructure." [] subset: 3_STAR synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC] synonym: "elementary particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:33238 name: monoatomic entity namespace: chebi_ontology def: "A monoatomic entity is a molecular entity consisting of a single atom." [] subset: 3_STAR synonym: "atomic entity" RELATED [ChEBI] synonym: "monoatomic entities" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33241 name: oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_functional_parent CHEBI:24833 ! oxoacid [Term] id: CHEBI:33242 name: inorganic hydride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic hydrides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:33245 name: organic fundamental parent namespace: chebi_ontology def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." [] subset: 3_STAR synonym: "organic fundamental parents" RELATED [ChEBI] synonym: "organic parent hydrides" RELATED [ChEBI] is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33246 name: inorganic group namespace: chebi_ontology def: "Any substituent group which does not contain carbon." [] subset: 3_STAR synonym: "inorganic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:33247 name: organic group namespace: chebi_ontology def: "Any substituent group or skeleton containing carbon." [] subset: 3_STAR synonym: "organic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group [Term] id: CHEBI:33249 name: organyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." [] subset: 3_STAR synonym: "groupe organyle" RELATED [IUPAC] synonym: "grupo organilo" RELATED [IUPAC] synonym: "grupos organilo" RELATED [IUPAC] synonym: "organyl group" EXACT IUPAC_NAME [IUPAC] synonym: "organyl groups" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51447 ! organic univalent group [Term] id: CHEBI:33250 name: atom namespace: chebi_ontology alt_id: CHEBI:22671 alt_id: CHEBI:23907 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." [] subset: 3_STAR synonym: "atom" EXACT IUPAC_NAME [IUPAC] synonym: "atome" RELATED [IUPAC] synonym: "atomo" RELATED [IUPAC] synonym: "atoms" RELATED [ChEBI] synonym: "atomus" RELATED [ChEBI] synonym: "element" RELATED [ChEBI] synonym: "elements" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:10545 ! electron relationship: has_part CHEBI:33252 ! atomic nucleus [Term] id: CHEBI:33252 name: atomic nucleus namespace: chebi_ontology def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." [] subset: 3_STAR synonym: "Atomkern" RELATED [ChEBI] synonym: "Kern" RELATED [ChEBI] synonym: "noyau" RELATED [IUPAC] synonym: "noyau atomique" RELATED [ChEBI] synonym: "nuclei" RELATED [ChEBI] synonym: "nucleo" RELATED [IUPAC] synonym: "nucleo atomico" RELATED [ChEBI] synonym: "nucleus" EXACT IUPAC_NAME [IUPAC] synonym: "nucleus atomi" RELATED [ChEBI] is_a: CHEBI:36347 ! nuclear particle relationship: has_part CHEBI:33253 ! nucleon [Term] id: CHEBI:33253 name: nucleon namespace: chebi_ontology def: "Heavy nuclear particle: proton or neutron." [] subset: 3_STAR synonym: "nucleon" EXACT [IUPAC] synonym: "nucleon" EXACT IUPAC_NAME [IUPAC] synonym: "nucleons" RELATED [ChEBI] synonym: "Nukleon" RELATED [ChEBI] synonym: "Nukleonen" RELATED [ChEBI] is_a: CHEBI:36339 ! baryon is_a: CHEBI:36347 ! nuclear particle [Term] id: CHEBI:33256 name: primary amide namespace: chebi_ontology def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "primary amide" EXACT [IUPAC] synonym: "primary amides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33259 name: elemental molecular entity namespace: chebi_ontology def: "A molecular entity all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic entity" RELATED [ChEBI] synonym: "homoatomic molecular entities" RELATED [ChEBI] synonym: "homoatomic molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33262 name: elemental oxygen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33263 name: diatomic oxygen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33262 ! elemental oxygen [Term] id: CHEBI:33273 name: polyatomic anion namespace: chebi_ontology def: "An anion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion [Term] id: CHEBI:33280 name: molecular messenger namespace: chebi_ontology subset: 3_STAR synonym: "chemical messenger" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33281 name: antimicrobial agent namespace: chebi_ontology alt_id: CHEBI:22582 def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." [] subset: 3_STAR synonym: "antibiotic" RELATED [ChEBI] synonym: "antibiotics" RELATED [ChEBI] synonym: "Antibiotika" RELATED [ChEBI] synonym: "Antibiotikum" RELATED [ChEBI] synonym: "antibiotique" RELATED [IUPAC] synonym: "antimicrobial" RELATED [ChEBI] synonym: "antimicrobial agents" RELATED [ChEBI] synonym: "antimicrobials" RELATED [ChEBI] synonym: "microbicide" RELATED [ChEBI] synonym: "microbicides" RELATED [ChEBI] xref: PMID:12964249 {source="Europe PMC"} xref: PMID:22117953 {source="Europe PMC"} xref: PMID:22439833 {source="Europe PMC"} xref: PMID:22849268 {source="Europe PMC"} xref: PMID:22849276 {source="Europe PMC"} xref: PMID:22958833 {source="Europe PMC"} is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33284 name: nutrient namespace: chebi_ontology def: "A nutrient is a food component that an organism uses to survive and grow." [] subset: 3_STAR synonym: "nutrients" RELATED [ChEBI] is_a: CHEBI:78295 ! food component [Term] id: CHEBI:33285 name: heteroorganic entity namespace: chebi_ontology def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." [] subset: 3_STAR synonym: "heteroorganic entities" RELATED [ChEBI] synonym: "organoelement compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33296 name: alkali metal molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of an alkali metal." [] subset: 3_STAR synonym: "alkali metal molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:22314 ! alkali metal atom [Term] id: CHEBI:33300 name: pnictogen namespace: chebi_ontology def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." [] subset: 3_STAR synonym: "group 15 elements" RELATED [ChEBI] synonym: "group V elements" RELATED [ChEBI] synonym: "nitrogenoideos" RELATED [ChEBI] synonym: "nitrogenoides" RELATED [ChEBI] synonym: "pnictogene" RELATED [ChEBI] synonym: "pnictogenes" RELATED [ChEBI] synonym: "pnictogens" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33302 name: pnictogen molecular entity namespace: chebi_ontology def: "A p-block molecular entity containing any pnictogen." [] subset: 3_STAR synonym: "pnictogen molecular entities" RELATED [ChEBI] synonym: "pnictogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33300 ! pnictogen [Term] id: CHEBI:33303 name: chalcogen namespace: chebi_ontology def: "Any p-block element belonging to the group 16 family of the periodic table." [] subset: 3_STAR synonym: "anfigeno" RELATED [ChEBI] synonym: "anfigenos" RELATED [ChEBI] synonym: "calcogeno" RELATED [ChEBI] synonym: "calcogenos" RELATED [ChEBI] synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC] synonym: "chalcogene" RELATED [ChEBI] synonym: "chalcogenes" RELATED [ChEBI] synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC] synonym: "Chalkogen" RELATED [ChEBI] synonym: "Chalkogene" RELATED [ChEBI] synonym: "group 16 elements" RELATED [ChEBI] synonym: "group VI elements" RELATED [ChEBI] xref: PMID:17084588 {source="Europe PMC"} is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] subset: 3_STAR synonym: "chalcogen compounds" RELATED [ChEBI] synonym: "chalcogen molecular entities" RELATED [ChEBI] synonym: "chalcogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33303 ! chalcogen [Term] id: CHEBI:33306 name: carbon group element atom namespace: chebi_ontology subset: 3_STAR synonym: "carbon group element" RELATED [ChEBI] synonym: "carbon group elements" RELATED [ChEBI] synonym: "carbonoides" RELATED [ChEBI] synonym: "cristallogene" RELATED [ChEBI] synonym: "cristallogenes" RELATED [ChEBI] synonym: "group 14 elements" EXACT IUPAC_NAME [IUPAC] synonym: "group IV elements" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33308 name: carboxylic ester namespace: chebi_ontology alt_id: CHEBI:13204 alt_id: CHEBI:23028 alt_id: CHEBI:3408 def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." [] subset: 3_STAR synonym: "a carboxylic ester" RELATED [UniProt] synonym: "carboxylic acid esters" RELATED [ChEBI] synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND] synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02391 xref: Wikipedia:Ester is_a: CHEBI:35701 ! ester is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:33318 name: main group element atom namespace: chebi_ontology def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." [] subset: 3_STAR synonym: "Hauptgruppenelement" RELATED [ChEBI] synonym: "Hauptgruppenelemente" RELATED [ChEBI] synonym: "main group element" RELATED [ChEBI] synonym: "main group elements" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33402 name: sulfur oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "oxoacids of sulfur" RELATED [ChEBI] synonym: "sulfur oxoacids" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33484 ! chalcogen oxoacid [Term] id: CHEBI:33424 name: sulfur oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfur oxoacid derivative" EXACT [ChEBI] synonym: "sulfur oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative [Term] id: CHEBI:33482 name: sulfur oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of sulfur" RELATED [ChEBI] synonym: "sulfur oxoanion" EXACT [ChEBI] synonym: "sulfur oxoanions" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion [Term] id: CHEBI:33484 name: chalcogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoacid" EXACT [ChEBI] synonym: "chalcogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid relationship: has_role CHEBI:138103 ! inorganic acid [Term] id: CHEBI:33485 name: chalcogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoanion" EXACT [ChEBI] synonym: "chalcogen oxoanions" RELATED [ChEBI] is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33504 name: alkali metal cation namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal cations" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33521 name: metal atom namespace: chebi_ontology alt_id: CHEBI:25217 alt_id: CHEBI:6788 def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." [] subset: 3_STAR synonym: "elemental metal" RELATED [ChEBI] synonym: "elemental metals" RELATED [ChEBI] synonym: "metal element" RELATED [ChEBI] synonym: "metal elements" RELATED [ChEBI] synonym: "metals" RELATED [ChEBI] xref: KEGG:C00050 xref: PMID:21784043 {source="Europe PMC"} xref: Wikipedia:Metal is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33558 name: alpha-amino-acid anion namespace: chebi_ontology def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino acid anions" RELATED [ChEBI] synonym: "alpha-amino-acid anion" EXACT [ChEBI] synonym: "alpha-amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33559 name: s-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "s-block element" RELATED [ChEBI] synonym: "s-block elements" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33560 name: p-block element atom namespace: chebi_ontology def: "Any main group element atom belonging to the p-block of the periodic table." [] subset: 3_STAR synonym: "p-block element" RELATED [ChEBI] synonym: "p-block elements" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom [Term] id: CHEBI:33566 name: catechols namespace: chebi_ontology alt_id: CHEBI:134187 alt_id: CHEBI:13628 alt_id: CHEBI:18862 def: "Any compound containing an o-diphenol component." [] subset: 3_STAR synonym: "1,2-benzenediols" RELATED [ChEBI] synonym: "a catechol" RELATED [UniProt] synonym: "benzene-1,2-diols" RELATED [ChEBI] xref: KEGG:C15571 is_a: CHEBI:33570 ! benzenediols [Term] id: CHEBI:33567 name: catecholamine namespace: chebi_ontology alt_id: CHEBI:23056 alt_id: CHEBI:3468 def: "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [] subset: 3_STAR synonym: "Catecholamine" EXACT [KEGG_COMPOUND] synonym: "catecholamines" EXACT IUPAC_NAME [IUPAC] synonym: "catecholamines" RELATED [ChEBI] xref: KEGG:C02012 is_a: CHEBI:25375 ! monoamine molecular messenger is_a: CHEBI:33566 ! catechols [Term] id: CHEBI:33569 name: noradrenaline namespace: chebi_ontology def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." [] subset: 3_STAR synonym: "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] synonym: "noradrenalina" RELATED [ChEBI] synonym: "norepinephrine" RELATED [ChEBI] xref: Beilstein:2210994 {source="Beilstein"} xref: CAS:138-65-8 {source="NIST Chemistry WebBook"} xref: CAS:138-65-8 {source="ChemIDplus"} xref: Gmelin:863925 {source="Gmelin"} xref: LINCS:LSM-5181 is_a: CHEBI:33567 ! catecholamine relationship: has_role CHEBI:76967 ! human xenobiotic metabolite relationship: is_conjugate_base_of CHEBI:166902 ! noradrenaline(1+) [Term] id: CHEBI:33570 name: benzenediols namespace: chebi_ontology alt_id: CHEBI:22705 alt_id: CHEBI:22711 subset: 3_STAR is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33571 name: (S)-noradrenaline namespace: chebi_ontology def: "The S-enantiomer of noradrenaline." [] subset: 3_STAR synonym: "4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:2937999 {source="Beilstein"} xref: LINCS:LSM-37072 xref: Reaxys:2937999 {source="Reaxys"} is_a: CHEBI:33569 ! noradrenaline relationship: is_enantiomer_of CHEBI:18357 ! (R)-noradrenaline [Term] id: CHEBI:33575 name: carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13428 alt_id: CHEBI:13627 alt_id: CHEBI:23027 def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." [] subset: 3_STAR synonym: "acide carboxylique" RELATED [IUPAC] synonym: "acides carboxyliques" RELATED [IUPAC] synonym: "acido carboxilico" RELATED [IUPAC] synonym: "acidos carboxilicos" RELATED [IUPAC] synonym: "Carbonsaeure" RELATED [ChEBI] synonym: "Carbonsaeuren" RELATED [ChEBI] synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Karbonsaeure" RELATED [ChEBI] synonym: "RC(=O)OH" RELATED [IUPAC] xref: PMID:17147560 {source="Europe PMC"} xref: PMID:18433345 {source="Europe PMC"} xref: Wikipedia:Carboxylic_acid is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid relationship: has_part CHEBI:46883 ! carboxy group relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] subset: 3_STAR synonym: "main group compounds" RELATED [ChEBI] synonym: "main group molecular entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:33318 ! main group element atom [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "carbon group molecular entities" RELATED [ChEBI] synonym: "carbon group molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33306 ! carbon group element atom [Term] id: CHEBI:33595 name: cyclic compound namespace: chebi_ontology def: "Any molecule that consists of a series of atoms joined together to form a ring." [] subset: 3_STAR synonym: "cyclic compounds" RELATED [ChEBI] xref: Wikipedia:Cyclic_compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "hydrogen compounds" RELATED [ChEBI] synonym: "hydrogen molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:49637 ! hydrogen atom [Term] id: CHEBI:33635 name: polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33636 name: bicyclic compound namespace: chebi_ontology def: "A molecule that features two fused rings." [] subset: 3_STAR synonym: "bicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33655 name: aromatic compound namespace: chebi_ontology def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [] subset: 3_STAR synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "aromatics" RELATED [ChEBI] synonym: "aromatische Verbindungen" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33659 name: organic aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic aromatic compounds" RELATED [ChEBI] is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33671 name: heteropolycyclic compound namespace: chebi_ontology def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." [] subset: 3_STAR synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "polyheterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33672 name: heterobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." [] subset: 3_STAR synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] subset: 3_STAR synonym: "s-block compounds" RELATED [ChEBI] synonym: "s-block molecular entities" RELATED [ChEBI] synonym: "s-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33559 ! s-block element atom [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A main group molecular entity that contains one or more atoms of a p-block element." [] subset: 3_STAR synonym: "p-block compounds" RELATED [ChEBI] synonym: "p-block molecular entities" RELATED [ChEBI] synonym: "p-block molecular entitiy" RELATED [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33692 name: hydrides namespace: chebi_ontology def: "Hydrides are chemical compounds of hydrogen with other chemical elements." [] subset: 3_STAR is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33693 name: oxygen hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of oxygen" RELATED [ChEBI] synonym: "oxygen hydride" EXACT [ChEBI] synonym: "oxygen hydrides" RELATED [ChEBI] is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33694 name: biomacromolecule namespace: chebi_ontology def: "A macromolecule formed by a living organism." [] subset: 3_STAR synonym: "biomacromolecules" RELATED [ChEBI] synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC] synonym: "Biopolymere" RELATED [ChEBI] synonym: "biopolymers" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33695 name: information biomacromolecule namespace: chebi_ontology subset: 3_STAR synonym: "genetically encoded biomacromolecules" RELATED [ChEBI] synonym: "genetically encoded biopolymers" RELATED [ChEBI] synonym: "information biomacromolecules" RELATED [ChEBI] synonym: "information biopolymers" RELATED [ChEBI] synonym: "information macromolecule" RELATED [ChEBI] synonym: "information macromolecules" RELATED [ChEBI] is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:33696 name: nucleic acid namespace: chebi_ontology def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." [] subset: 3_STAR synonym: "acide nucleique" RELATED [ChEBI] synonym: "acides nucleiques" RELATED [ChEBI] synonym: "acido nucleico" RELATED [ChEBI] synonym: "acidos nucleicos" RELATED [ChEBI] synonym: "NA" RELATED [ChEBI] synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Nukleinsaeure" RELATED [ChEBI] synonym: "Nukleinsaeuren" RELATED [ChEBI] is_a: CHEBI:15986 ! polynucleotide relationship: has_part CHEBI:33791 ! canonical nucleoside residue relationship: has_part CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:33697 name: ribonucleic acid namespace: chebi_ontology def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." [] subset: 3_STAR synonym: "pentosenucleic acids" RELATED [ChemIDplus] synonym: "ribonucleic acid" EXACT [IUPAC] synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "ribonucleic acids" RELATED [ChEBI] synonym: "Ribonukleinsaeure" RELATED [ChEBI] synonym: "ribose nucleic acid" RELATED [ChEBI] synonym: "RNA" RELATED [UniProt] synonym: "RNA" RELATED [IUPAC] synonym: "RNS" RELATED [ChEBI] synonym: "yeast nucleic acid" RELATED [ChEBI] xref: CAS:63231-63-0 {source="ChemIDplus"} is_a: CHEBI:33696 ! nucleic acid relationship: has_part CHEBI:33792 ! canonical ribonucleoside residue relationship: has_part CHEBI:50299 ! canonical ribonucleotide residue [Term] id: CHEBI:33700 name: proteinogenic amino-acid residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical amino-acid residue" RELATED [ChEBI] synonym: "canonical amino-acid residues" RELATED [ChEBI] synonym: "common amino acid residues" RELATED [ChEBI] synonym: "proteinogenic amino-acid residues" RELATED [ChEBI] synonym: "standard amino acid residues" RELATED [ChEBI] synonym: "standard amino-acid residues" RELATED [ChEBI] is_a: CHEBI:33710 ! alpha-amino-acid residue [Term] id: CHEBI:33702 name: polyatomic cation namespace: chebi_ontology def: "A cation consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic cations" RELATED [ChEBI] is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:33703 name: amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "amino acid cation" RELATED [ChEBI] synonym: "amino-acid cation" EXACT [ChEBI] synonym: "amino-acid cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:33702 ! polyatomic cation relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid [Term] id: CHEBI:33704 name: alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:10208 alt_id: CHEBI:13779 alt_id: CHEBI:22442 alt_id: CHEBI:2642 def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." [] subset: 3_STAR synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-amino acids" RELATED [JCBN] synonym: "alpha-amino acids" RELATED [ChEBI] synonym: "alpha-amino carboxylic acids" RELATED [IUPAC] synonym: "Amino acid" RELATED [KEGG_COMPOUND] synonym: "Amino acids" RELATED [KEGG_COMPOUND] xref: KEGG:C00045 xref: KEGG:C05167 is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation relationship: is_tautomer_of CHEBI:78608 ! alpha-amino acid zwitterion [Term] id: CHEBI:33708 name: amino-acid residue namespace: chebi_ontology def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [] subset: 3_STAR synonym: "amino acid residue" RELATED [ChEBI] synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC] synonym: "amino-acid residues" RELATED [JCBN] is_a: CHEBI:33247 ! organic group relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue relationship: is_substituent_group_from CHEBI:33709 ! amino acid [Term] id: CHEBI:33709 name: amino acid namespace: chebi_ontology alt_id: CHEBI:13815 alt_id: CHEBI:22477 def: "A carboxylic acid containing one or more amino groups." [] subset: 3_STAR synonym: "amino acids" RELATED [ChEBI] synonym: "Aminocarbonsaeure" RELATED [ChEBI] synonym: "Aminokarbonsaeure" RELATED [ChEBI] synonym: "Aminosaeure" RELATED [ChEBI] xref: Wikipedia:Amino_acid is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation [Term] id: CHEBI:33710 name: alpha-amino-acid residue namespace: chebi_ontology def: "An amino-acid residue derived from an alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino-acid residues" RELATED [ChEBI] synonym: "an alpha-amino acid residue" RELATED [UniProt] is_a: CHEBI:33708 ! amino-acid residue relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33719 name: alpha-amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "alpha-amino acid cations" RELATED [ChEBI] synonym: "alpha-amino-acid cation" EXACT [ChEBI] synonym: "alpha-amino-acid cations" RELATED [ChEBI] is_a: CHEBI:33703 ! amino-acid cation relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33720 name: carbohydrate acid namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate acid" EXACT [ChEBI] synonym: "carbohydrate acids" RELATED [ChEBI] is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:33721 ! carbohydrate acid anion [Term] id: CHEBI:33721 name: carbohydrate acid anion namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate acid anion" EXACT [ChEBI] synonym: "carbohydrate acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:33720 ! carbohydrate acid [Term] id: CHEBI:33791 name: canonical nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleoside residues" RELATED [ChEBI] synonym: "common nucleoside residues" RELATED [CBN] synonym: "nucleoside residue" RELATED [CBN] synonym: "standard nucleoside residues" RELATED [ChEBI] is_a: CHEBI:50320 ! nucleoside residue [Term] id: CHEBI:33792 name: canonical ribonucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleoside residues" RELATED [ChEBI] synonym: "common ribonucleoside residue" RELATED [CBN] synonym: "common ribonucleoside residues" RELATED [CBN] synonym: "N" RELATED [CBN] synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue [Term] id: CHEBI:33793 name: canonical deoxyribonucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical deoxyribonucleoside residues" RELATED [ChEBI] synonym: "common 2'-deoxyribonucleoside residue" RELATED [CBN] synonym: "common 2'-deoxyribonucleoside residues" RELATED [CBN] synonym: "dN" RELATED [CBN] synonym: "dNuc" RELATED [CBN] synonym: "standard deoxyribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology alt_id: CHEBI:64710 def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] subset: 3_STAR synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organic alcohol" RELATED [ChEBI] synonym: "organic hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound namespace: chebi_ontology def: "Any organic molecule that consists of atoms connected in the form of a ring." [] subset: 3_STAR synonym: "organic cyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33833 name: heteroarene namespace: chebi_ontology def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." [] subset: 3_STAR synonym: "hetarenes" RELATED [IUPAC] synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33837 name: conjugated protein namespace: chebi_ontology def: "Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion." [] subset: 3_STAR synonym: "complex protein" RELATED [COMe] synonym: "conjugated proteins" EXACT IUPAC_NAME [IUPAC] xref: COMe:PRX000001 is_a: CHEBI:36080 ! protein [Term] id: CHEBI:33839 name: macromolecule namespace: chebi_ontology def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [] subset: 3_STAR synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC] synonym: "macromolecules" RELATED [ChEBI] synonym: "polymer" RELATED [ChEBI] synonym: "polymer molecule" RELATED [IUPAC] synonym: "polymers" RELATED [ChEBI] xref: Wikipedia:Macromolecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:33853 name: phenols namespace: chebi_ontology alt_id: CHEBI:13664 alt_id: CHEBI:13825 alt_id: CHEBI:25969 alt_id: CHEBI:2857 def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." [] subset: 3_STAR synonym: "a phenol" RELATED [UniProt] synonym: "arenols" RELATED [IUPAC] synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND] synonym: "phenols" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C15584 xref: MetaCyc:Phenols xref: Wikipedia:Phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:33893 name: reagent namespace: chebi_ontology def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." [] subset: 3_STAR synonym: "reactif" RELATED [IUPAC] synonym: "reactivo" RELATED [IUPAC] synonym: "reagent" EXACT IUPAC_NAME [IUPAC] synonym: "reagents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:33917 name: aldohexose namespace: chebi_ontology alt_id: CHEBI:2558 def: "A hexose with a (potential) aldehyde group at one end." [] subset: 3_STAR synonym: "aldohexose" EXACT [ChEBI] synonym: "aldohexoses" RELATED [ChEBI] is_a: CHEBI:15693 ! aldose is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:33937 name: macronutrient namespace: chebi_ontology def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." [] subset: 3_STAR synonym: "macronutrients" RELATED [ChEBI] is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:350546 name: serotonin(1+) namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3." [] subset: 3_STAR synonym: "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "serotonin" RELATED [UniProt] synonym: "serotonin cation" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35274 ! ammonium ion derivative relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:28790 ! serotonin [Term] id: CHEBI:35106 name: nitrogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen hydrides" RELATED [ChEBI] is_a: CHEBI:35881 ! pnictogen hydride is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35107 name: azane namespace: chebi_ontology def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." [] subset: 3_STAR synonym: "azanes" RELATED [ChEBI] is_a: CHEBI:35106 ! nitrogen hydride [Term] id: CHEBI:35222 name: inhibitor namespace: chebi_ontology def: "A substance that diminishes the rate of a chemical reaction." [] subset: 3_STAR synonym: "inhibidor" RELATED [ChEBI] synonym: "inhibiteur" RELATED [ChEBI] synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "inhibitors" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35223 name: catalyst namespace: chebi_ontology def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." [] subset: 3_STAR synonym: "catalizador" RELATED [ChEBI] synonym: "catalyseur" RELATED [ChEBI] synonym: "catalyst" EXACT IUPAC_NAME [IUPAC] synonym: "Katalysator" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:35238 name: amino acid zwitterion namespace: chebi_ontology def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." [] subset: 3_STAR synonym: "amino acid zwitterion" EXACT [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35267 name: quaternary ammonium ion namespace: chebi_ontology alt_id: CHEBI:26470 alt_id: CHEBI:8693 def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." [] subset: 3_STAR synonym: "a quaternary ammonium" RELATED [UniProt] synonym: "Quaternary amine" RELATED [KEGG_COMPOUND] synonym: "quaternary ammonium ion" EXACT IUPAC_NAME [IUPAC] synonym: "quaternary ammonium ions" RELATED [ChEBI] xref: KEGG:C06703 is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative [Term] id: CHEBI:35274 name: ammonium ion derivative namespace: chebi_ontology def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." [] subset: 3_STAR synonym: "ammonium ion derivatives" RELATED [ChEBI] synonym: "azanium ion derivative" RELATED [ChEBI] synonym: "azanium ion derivatives" RELATED [ChEBI] is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_parent_hydride CHEBI:28938 ! ammonium [Term] id: CHEBI:35287 name: acylcholine namespace: chebi_ontology alt_id: CHEBI:13245 alt_id: CHEBI:22227 alt_id: CHEBI:2463 def: "A choline ester formed from choline and a carboxylic acid." [] subset: 3_STAR synonym: "acylcholines" RELATED [ChEBI] synonym: "an acylcholine" RELATED [UniProt] xref: KEGG:C01777 is_a: CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:35341 name: steroid namespace: chebi_ontology alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." [] subset: 3_STAR synonym: "a steroid" RELATED [UniProt] synonym: "Steroid" EXACT [KEGG_COMPOUND] synonym: "steroids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00377 xref: MetaCyc:Steroids is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:35350 name: hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:24748 alt_id: CHEBI:5814 subset: 3_STAR synonym: "hydroxy steroids" RELATED [ChEBI] synonym: "Hydroxysteroid" RELATED [KEGG_COMPOUND] synonym: "hydroxysteroids" RELATED [ChEBI] xref: KEGG:C02159 is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:35352 name: organonitrogen compound namespace: chebi_ontology def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [] subset: 3_STAR synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organonitrogens" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35381 name: monosaccharide namespace: chebi_ontology alt_id: CHEBI:25407 alt_id: CHEBI:6984 def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." [] subset: 3_STAR synonym: "monosacarido" RELATED [ChEBI] synonym: "monosacaridos" RELATED [IUPAC] synonym: "Monosaccharid" RELATED [ChEBI] synonym: "Monosaccharide" EXACT [KEGG_COMPOUND] synonym: "monosaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Monosacharid" RELATED [ChEBI] xref: KEGG:C06698 is_a: CHEBI:16646 ! carbohydrate [Term] id: CHEBI:35406 name: oxoanion namespace: chebi_ontology alt_id: CHEBI:33274 alt_id: CHEBI:33436 def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." [] subset: 3_STAR synonym: "oxoacid anions" RELATED [ChEBI] synonym: "oxoanion" EXACT [ChEBI] synonym: "oxoanions" RELATED [ChEBI] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion [Term] id: CHEBI:35472 name: anti-inflammatory drug namespace: chebi_ontology def: "A substance that reduces or suppresses inflammation." [] subset: 3_STAR synonym: "anti-inflammatory drugs" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory drug" RELATED [ChEBI] synonym: "antiinflammatory drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:67079 ! anti-inflammatory agent [Term] id: CHEBI:35479 name: alkali metal salt namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal salts" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity [Term] id: CHEBI:35507 name: natural product fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "natural product fundamental parents" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35508 name: steroid fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "steroid fundamental parents" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:35507 ! natural product fundamental parent [Term] id: CHEBI:35519 name: cholane namespace: chebi_ontology subset: 3_STAR synonym: "cholane" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35508 ! steroid fundamental parent [Term] id: CHEBI:35524 name: sympathomimetic agent namespace: chebi_ontology def: "A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." [] subset: 3_STAR synonym: "sympathomimetic" RELATED [ChEBI] synonym: "sympathomimetics" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:35554 name: cardiovascular drug namespace: chebi_ontology def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." [] subset: 3_STAR synonym: "cardiovascular agent" RELATED [ChEBI] synonym: "cardiovascular drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35569 name: alpha-adrenergic agonist namespace: chebi_ontology def: "An agent that selectively binds to and activates alpha-adrenergic receptors." [] subset: 3_STAR synonym: "alpha-adrenergic agonists" RELATED [ChEBI] synonym: "alpha-adrenergic receptor agonist" RELATED [ChEBI] synonym: "alpha-adrenoceptor agonists" RELATED [IUPHAR] is_a: CHEBI:37886 ! adrenergic agonist is_a: CHEBI:48539 ! alpha-adrenergic drug [Term] id: CHEBI:35604 name: carbon oxoanion namespace: chebi_ontology def: "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." [] subset: 3_STAR synonym: "carbon oxoanion" EXACT [ChEBI] synonym: "carbon oxoanions" RELATED [ChEBI] synonym: "oxocarbon anion" RELATED [ChEBI] synonym: "oxocarbon anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35605 name: carbon oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "carbon oxoacids" RELATED [ChEBI] synonym: "oxoacids of carbon" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35620 name: vasodilator agent namespace: chebi_ontology def: "A drug used to cause dilation of the blood vessels." [] subset: 3_STAR synonym: "vasodilator" RELATED [ChEBI] synonym: "vasodilator agents" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35692 name: dicarboxylic acid namespace: chebi_ontology alt_id: CHEBI:23692 alt_id: CHEBI:36172 alt_id: CHEBI:4501 def: "Any carboxylic acid containing two carboxy groups." [] subset: 3_STAR synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND] synonym: "dicarboxylic acids" RELATED [ChEBI] xref: KEGG:C02028 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35693 name: dicarboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "dicarboxylic acid anion" EXACT [ChEBI] synonym: "dicarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid [Term] id: CHEBI:35701 name: ester namespace: chebi_ontology alt_id: CHEBI:23960 alt_id: CHEBI:4859 def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." [] subset: 3_STAR synonym: "Ester" EXACT [KEGG_COMPOUND] synonym: "esters" RELATED [ChEBI] xref: KEGG:C00287 xref: Wikipedia:Ester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35722 name: sulfated glycosaminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "glycosaminoglycan sulfate" RELATED [ChEBI] synonym: "glycosaminoglycan sulfates" RELATED [ChEBI] synonym: "sulfated glycosaminoglycans" RELATED [ChEBI] is_a: CHEBI:18085 ! glycosaminoglycan is_a: CHEBI:35724 ! carbohydrate sulfate [Term] id: CHEBI:35724 name: carbohydrate sulfate namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate sulfates" RELATED [ChEBI] synonym: "carbohydrate sulphates" RELATED [ChEBI] is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:35757 name: monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13657 alt_id: CHEBI:25382 alt_id: CHEBI:3407 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a monocarboxylate" RELATED [UniProt] synonym: "Carboxylate" RELATED [KEGG_COMPOUND] synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND] synonym: "monocarboxylates" RELATED [ChEBI] synonym: "monocarboxylic acid anions" RELATED [ChEBI] xref: KEGG:C00060 is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid [Term] id: CHEBI:35881 name: pnictogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen hydride" EXACT [ChEBI] synonym: "pnictogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:35942 name: neurotransmitter agent namespace: chebi_ontology def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." [] subset: 3_STAR synonym: "neurotransmitter agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:36078 name: cholanoid namespace: chebi_ontology alt_id: CHEBI:22867 alt_id: CHEBI:50419 subset: 3_STAR synonym: "bile acids and derivatives" RELATED [LIPID_MAPS] synonym: "cholanoids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMST04 {source="LIPID MAPS"} is_a: CHEBI:35341 ! steroid relationship: has_parent_hydride CHEBI:35519 ! cholane [Term] id: CHEBI:36080 name: protein namespace: chebi_ontology alt_id: CHEBI:13677 alt_id: CHEBI:14911 def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." [] subset: 3_STAR synonym: "proteins" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33695 ! information biomacromolecule relationship: has_part CHEBI:16541 ! protein polypeptide chain [Term] id: CHEBI:36235 name: bile acid anion namespace: chebi_ontology subset: 3_STAR synonym: "bile acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:36237 name: cholanic acid namespace: chebi_ontology def: "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." [] subset: 3_STAR synonym: "cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:25312-65-6 {source="ChemIDplus"} xref: Patent:JP2008069152 xref: Reaxys:13246008 {source="Reaxys"} is_a: CHEBI:36278 ! cholanic acids [Term] id: CHEBI:36238 name: 5beta-cholanic acid namespace: chebi_ontology subset: 3_STAR synonym: "(5beta)-cholan-24-oic acid" RELATED [ChemIDplus] synonym: "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" RELATED [ChemIDplus] synonym: "5beta-cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] synonym: "5beta-cholanic acid" EXACT [ChemIDplus] synonym: "5beta-cholanoic acid" RELATED [ChemIDplus] synonym: "ursocholanic acid" RELATED [ChemIDplus] xref: Beilstein:3214794 {source="Beilstein"} xref: CAS:546-18-9 {source="ChemIDplus"} xref: LIPID_MAPS_instance:LMST04010441 {source="LIPID MAPS"} is_a: CHEBI:36237 ! cholanic acid is_a: CHEBI:36248 ! 5beta-cholanic acids [Term] id: CHEBI:36248 name: 5beta-cholanic acids namespace: chebi_ontology def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." [] subset: 3_STAR is_a: CHEBI:136889 ! 5beta steroid is_a: CHEBI:36278 ! cholanic acids relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane [Term] id: CHEBI:36277 name: bile acid salt namespace: chebi_ontology def: "A salt of a bile acid." [] subset: 3_STAR synonym: "bile acid salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:36078 ! cholanoid [Term] id: CHEBI:36278 name: cholanic acids namespace: chebi_ontology alt_id: CHEBI:23166 alt_id: CHEBI:23211 subset: 1_STAR is_a: CHEBI:36078 ! cholanoid is_a: CHEBI:47891 ! steroid acid [Term] id: CHEBI:36338 name: lepton namespace: chebi_ontology def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." [] subset: 3_STAR synonym: "leptons" RELATED [ChEBI] is_a: CHEBI:33233 ! fundamental particle is_a: CHEBI:36340 ! fermion [Term] id: CHEBI:36339 name: baryon namespace: chebi_ontology def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." [] subset: 3_STAR synonym: "baryons" RELATED [ChEBI] is_a: CHEBI:36340 ! fermion is_a: CHEBI:36344 ! hadron [Term] id: CHEBI:36340 name: fermion namespace: chebi_ontology def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." [] subset: 3_STAR synonym: "fermion" EXACT IUPAC_NAME [IUPAC] synonym: "fermions" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36341 name: boson namespace: chebi_ontology def: "Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose." [] subset: 3_STAR synonym: "boson" EXACT IUPAC_NAME [IUPAC] synonym: "bosons" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36342 name: subatomic particle namespace: chebi_ontology def: "A particle smaller than an atom." [] subset: 3_STAR synonym: "subatomic particles" RELATED [ChEBI] xref: Wikipedia:Subatomic_particle [Term] id: CHEBI:36343 name: composite particle namespace: chebi_ontology def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." [] subset: 3_STAR synonym: "composite particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36344 name: hadron namespace: chebi_ontology def: "Hadron is a subatomic particle which experiences the strong force." [] subset: 3_STAR synonym: "hadrons" RELATED [ChEBI] is_a: CHEBI:36343 ! composite particle [Term] id: CHEBI:36347 name: nuclear particle namespace: chebi_ontology def: "A nucleus or any of its constituents in any of their energy states." [] subset: 3_STAR synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:24433 ! group [Term] id: CHEBI:36358 name: polyatomic ion namespace: chebi_ontology def: "An ion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:36586 name: carbonyl compound namespace: chebi_ontology def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." [] subset: 3_STAR synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23019 ! carbonyl group [Term] id: CHEBI:36587 name: organic oxo compound namespace: chebi_ontology def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." [] subset: 3_STAR synonym: "organic oxo compounds" RELATED [ChEBI] synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:72695 ! organic molecule relationship: has_part CHEBI:46629 ! oxo group [Term] id: CHEBI:36735 name: biladienes namespace: chebi_ontology def: "Compounds based on a biladiene skeleton." [] subset: 3_STAR is_a: CHEBI:25046 ! linear tetrapyrrole [Term] id: CHEBI:36902 name: chalcogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen hydride" EXACT [ChEBI] synonym: "chalcogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36914 name: inorganic ion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic ions" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36915 name: inorganic cation namespace: chebi_ontology subset: 3_STAR synonym: "inorganic cations" RELATED [ChEBI] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:36916 name: cation namespace: chebi_ontology alt_id: CHEBI:23058 alt_id: CHEBI:3473 def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." [] subset: 3_STAR synonym: "Cation" EXACT [KEGG_COMPOUND] synonym: "cation" EXACT IUPAC_NAME [IUPAC] synonym: "cation" EXACT [ChEBI] synonym: "cationes" RELATED [ChEBI] synonym: "cations" RELATED [ChEBI] synonym: "Kation" RELATED [ChEBI] synonym: "Kationen" RELATED [ChEBI] xref: KEGG:C01373 is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36961 name: chalcocarbonic acid namespace: chebi_ontology subset: 3_STAR synonym: "chalcocarbonic acid" EXACT [ChEBI] synonym: "chalcocarbonic acids" EXACT IUPAC_NAME [IUPAC] synonym: "chalcocarbonic acids" RELATED [ChEBI] is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36962 name: organochalcogen compound namespace: chebi_ontology def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." [] subset: 3_STAR synonym: "organochalcogen compound" EXACT [ChEBI] synonym: "organochalcogen compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36963 name: organooxygen compound namespace: chebi_ontology def: "An organochalcogen compound containing at least one carbon-oxygen bond." [] subset: 3_STAR synonym: "organooxygen compound" EXACT [ChEBI] synonym: "organooxygen compounds" RELATED [ChEBI] xref: PMID:17586126 {source="Europe PMC"} is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:37022 name: amino-acid anion namespace: chebi_ontology subset: 3_STAR synonym: "amino acid anions" RELATED [ChEBI] synonym: "amino-acid anion" EXACT [ChEBI] synonym: "amino-acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound relationship: is_conjugate_base_of CHEBI:33709 ! amino acid [Term] id: CHEBI:37163 name: glucan namespace: chebi_ontology alt_id: CHEBI:24255 alt_id: CHEBI:5392 def: "A polysaccharide composed of glucose residues." [] subset: 3_STAR synonym: "Glucan" EXACT [KEGG_COMPOUND] synonym: "glucan" EXACT IUPAC_NAME [IUPAC] synonym: "glucans" RELATED [ChEBI] xref: CAS:9037-91-6 {source="ChemIDplus"} xref: KEGG:C01379 is_a: CHEBI:37164 ! homopolysaccharide [Term] id: CHEBI:37164 name: homopolysaccharide namespace: chebi_ontology def: "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." [] subset: 3_STAR synonym: "homoglycan" RELATED [IUPAC] synonym: "homopolysaccharide" EXACT IUPAC_NAME [IUPAC] synonym: "homopolysaccharides" RELATED [ChEBI] is_a: CHEBI:18154 ! polysaccharide [Term] id: CHEBI:37175 name: organic hydride namespace: chebi_ontology subset: 3_STAR synonym: "organic hydrides" RELATED [ChEBI] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37176 name: mononuclear parent hydride namespace: chebi_ontology subset: 3_STAR synonym: "mononuclear hydride" RELATED [ChEBI] synonym: "mononuclear hydrides" RELATED [IUPAC] synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37246 name: elemental sodium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26712 ! sodium molecular entity [Term] id: CHEBI:37395 name: mucopolysaccharide namespace: chebi_ontology alt_id: CHEBI:25425 alt_id: CHEBI:7011 def: "Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid." [] subset: 3_STAR synonym: "mucopolisacarido" RELATED [ChEBI] synonym: "mucopolisacaridos" RELATED [IUPAC] synonym: "Mucopolysaccharid" RELATED [ChEBI] synonym: "Mucopolysaccharide" EXACT [KEGG_COMPOUND] synonym: "mucopolysaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Mukopolysaccharid" RELATED [ChEBI] xref: KEGG:C05114 is_a: CHEBI:18085 ! glycosaminoglycan [Term] id: CHEBI:37527 name: acid namespace: chebi_ontology alt_id: CHEBI:13800 alt_id: CHEBI:13801 alt_id: CHEBI:22209 alt_id: CHEBI:2426 def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." [] subset: 3_STAR synonym: "Acid" EXACT [KEGG_COMPOUND] synonym: "acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide" RELATED [IUPAC] synonym: "acido" RELATED [ChEBI] synonym: "acids" RELATED [ChEBI] synonym: "Saeure" RELATED [ChEBI] synonym: "Saeuren" RELATED [ChEBI] xref: KEGG:C00174 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] subset: 3_STAR synonym: "chemical compound" RELATED [ChEBI] synonym: "heteroatomic molecular entities" RELATED [ChEBI] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:37622 name: carboxamide namespace: chebi_ontology alt_id: CHEBI:35354 alt_id: CHEBI:35355 def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC] synonym: "carboxamides" RELATED [ChEBI] synonym: "primary carboxamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23004 ! carbamoyl group [Term] id: CHEBI:37661 name: glucopyranose namespace: chebi_ontology subset: 3_STAR synonym: "glucopyranose" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:17234 ! glucose [Term] id: CHEBI:37826 name: sulfuric acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfuric acid derivative" EXACT [ChEBI] synonym: "sulfuric acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:37838 name: carboacyl group namespace: chebi_ontology def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "carboacyl groups" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl group" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl groups" RELATED [IUPAC] is_a: CHEBI:22221 ! acyl group relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:37886 name: adrenergic agonist namespace: chebi_ontology def: "An agent that selectively binds to and activates adrenergic receptors." [] subset: 3_STAR synonym: "adrenergic agonists" RELATED [ChEBI] synonym: "adrenergic receptor agonist" RELATED [ChEBI] synonym: "adrenoceptor agonists" RELATED [IUPHAR] synonym: "adrenomimetic" RELATED [ChEBI] synonym: "adrenomimetics" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:37962 name: adrenergic agent namespace: chebi_ontology def: "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter." [] subset: 3_STAR synonym: "adrenergic agents" RELATED [ChEBI] synonym: "adrenergic drug" RELATED [ChEBI] synonym: "adrenergic drugs" RELATED [ChEBI] synonym: "adrenergic neuron agents" RELATED [ChEBI] synonym: "adrenergics" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:38077 name: polypyrrole namespace: chebi_ontology def: "A compound composed of two or more pyrrole units." [] subset: 3_STAR synonym: "poly(pyrrole)s" RELATED [ChEBI] synonym: "polypyrroles" RELATED [ChEBI] synonym: "PPys" RELATED [ChEBI] xref: Beilstein:8538310 {source="Beilstein"} is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound namespace: chebi_ontology def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." [] subset: 3_STAR synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI] synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38166 name: organic heteropolycyclic compound namespace: chebi_ontology alt_id: CHEBI:25429 alt_id: CHEBI:38075 subset: 3_STAR synonym: "organic heteropolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:38180 name: polycyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38323 name: cholinergic drug namespace: chebi_ontology def: "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." [] subset: 3_STAR synonym: "cholinergic agent" RELATED [ChEBI] synonym: "cholinergic drugs" RELATED [ChEBI] synonym: "cholinomimetic" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:38324 name: cholinergic agonist namespace: chebi_ontology def: "Any drug that binds to and activates cholinergic receptors." [] subset: 3_STAR synonym: "acetylcholine agonist" RELATED [ChEBI] synonym: "acetylcholine agonists" RELATED [ChEBI] synonym: "acetylcholine receptor agonist" RELATED [IUPHAR] synonym: "cholinergic agonists" RELATED [ChEBI] synonym: "cholinomimetic" RELATED [ChEBI] synonym: "cholinomimetics" RELATED [ChEBI] is_a: CHEBI:38323 ! cholinergic drug [Term] id: CHEBI:38325 name: muscarinic agonist namespace: chebi_ontology def: "Any drug that binds to and activates a muscarinic cholinergic receptor." [] subset: 3_STAR synonym: "muscarinic acetylcholine receptor agonist" RELATED [ChEBI] synonym: "muscarinic agonists" RELATED [ChEBI] synonym: "muscarinic cholinergic agonist" RELATED [ChEBI] synonym: "muscarinic cholinergic agonists" RELATED [ChEBI] is_a: CHEBI:38324 ! cholinergic agonist [Term] id: CHEBI:38631 name: aminoalkylindole namespace: chebi_ontology alt_id: CHEBI:22503 alt_id: CHEBI:24792 subset: 3_STAR synonym: "aminoalkylindoles" RELATED [ChEBI] is_a: CHEBI:24828 ! indoles [Term] id: CHEBI:38700 name: organic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sodium salt" EXACT [ChEBI] synonym: "organic sodium salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38716 name: carboxylic acid dianion namespace: chebi_ontology def: "Any dianion containing at least one carboxy group." [] subset: 3_STAR synonym: "carboxylic acid dianion" EXACT [ChEBI] synonym: "carboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:38958 name: indole alkaloid namespace: chebi_ontology alt_id: CHEBI:24795 alt_id: CHEBI:5901 def: "An alkaloid containing an indole skeleton." [] subset: 3_STAR synonym: "Indole alkaloid" EXACT [KEGG_COMPOUND] synonym: "indole alkaloids" RELATED [ChEBI] xref: KEGG:C06073 xref: Wikipedia:Indole_alkaloid is_a: CHEBI:22315 ! alkaloid relationship: has_part CHEBI:73398 ! indole skeleton [Term] id: CHEBI:39141 name: Bronsted acid namespace: chebi_ontology def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." [] subset: 3_STAR synonym: "acide de Bronsted" RELATED [IUPAC] synonym: "Bronsted acid" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Saeure" RELATED [ChEBI] synonym: "donneur d'hydron" RELATED [IUPAC] synonym: "hydron donor" RELATED [IUPAC] is_a: CHEBI:17891 ! donor is_a: CHEBI:37527 ! acid [Term] id: CHEBI:39142 name: Bronsted base namespace: chebi_ontology def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." [] subset: 3_STAR synonym: "accepteur d'hydron" RELATED [IUPAC] synonym: "base de Bronsted" RELATED [IUPAC] synonym: "Bronsted base" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Base" RELATED [ChEBI] synonym: "hydron acceptor" RELATED [IUPAC] is_a: CHEBI:15339 ! acceptor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39144 name: Lewis base namespace: chebi_ontology def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." [] subset: 3_STAR synonym: "base de Lewis" RELATED [IUPAC] synonym: "donneur d'une paire d'electrons" RELATED [ChEBI] synonym: "electron donor" RELATED [ChEBI] synonym: "Lewis base" EXACT IUPAC_NAME [IUPAC] synonym: "Lewis-Base" RELATED [ChEBI] is_a: CHEBI:17891 ! donor is_a: CHEBI:22695 ! base [Term] id: CHEBI:41609 name: carbonate namespace: chebi_ontology alt_id: CHEBI:29201 alt_id: CHEBI:41605 subset: 3_STAR synonym: "[CO3](2-)" RELATED [IUPAC] synonym: "carbonate" EXACT [IUPAC] synonym: "CARBONATE ION" RELATED [PDBeChem] synonym: "CO3(2-)" RELATED [ChEBI] synonym: "Karbonat" RELATED [ChEBI] synonym: "trioxidocarbonate(2-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3600898 {source="Beilstein"} xref: CAS:3812-32-6 {source="ChemIDplus"} xref: Gmelin:1559 {source="Gmelin"} xref: PDBeChem:CO3 is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate [Term] id: CHEBI:4167 name: D-glucopyranose namespace: chebi_ontology def: "A glucopyranose having D-configuration." [] subset: 3_STAR synonym: "D-Glc" RELATED [ChEBI] synonym: "D-Glcp" RELATED [ChEBI] synonym: "D-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Glucose" RELATED [KEGG_COMPOUND] synonym: "D-glucose" RELATED [UniProt] synonym: "Dextrose" RELATED [KEGG_COMPOUND] synonym: "Glc-OH" RELATED [ChEBI] synonym: "Glucose" RELATED [KEGG_COMPOUND] synonym: "glucose" RELATED [ChEBI] synonym: "Grape sugar" RELATED [KEGG_COMPOUND] synonym: "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" RELATED [GlyTouCan] xref: Beilstein:1281604 {source="Beilstein"} xref: CAS:2280-44-6 {source="ChemIDplus"} xref: GlyGen:G15021LG xref: GlyTouCan:G15021LG xref: Gmelin:83256 {source="Gmelin"} xref: HMDB:HMDB0000122 xref: KEGG:C00031 xref: KEGG:D00009 xref: KNApSAcK:C00001122 xref: MetaCyc:D-Glucose xref: PMID:15987845 {source="Europe PMC"} xref: PMID:16901854 {source="Europe PMC"} xref: PMID:17336832 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17928662 {source="Europe PMC"} xref: PMID:19913595 {source="Europe PMC"} xref: PMID:26812026 {source="Europe PMC"} xref: PMID:32619908 {source="Europe PMC"} xref: PMID:7524207 {source="Europe PMC"} xref: PMID:9140037 {source="Europe PMC"} xref: PMID:9501190 {source="Europe PMC"} xref: PMID:9506998 {source="Europe PMC"} xref: PMID:9545565 {source="Europe PMC"} xref: Reaxys:1281604 {source="Reaxys"} xref: Wikipedia:Glucose is_a: CHEBI:17634 ! D-glucose is_a: CHEBI:37661 ! glucopyranose relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:76971 ! Escherichia coli metabolite relationship: has_role CHEBI:77746 ! human metabolite [Term] id: CHEBI:4194 name: D-hexose namespace: chebi_ontology def: "A hexose that has D-configuration at position 5." [] subset: 3_STAR synonym: "a D-hexose" RELATED [UniProt] synonym: "D-hexopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Hexose" EXACT [KEGG_COMPOUND] synonym: "D-hexoses" RELATED [ChEBI] xref: KEGG:C00738 is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:43176 name: hydroxy group namespace: chebi_ontology alt_id: CHEBI:24706 alt_id: CHEBI:43171 subset: 3_STAR synonym: "-OH" RELATED [IUPAC] synonym: "hydroxy" EXACT IUPAC_NAME [IUPAC] synonym: "HYDROXY GROUP" EXACT [PDBeChem] synonym: "hydroxy group" EXACT [UniProt] synonym: "hydroxyl" RELATED [ChEBI] synonym: "hydroxyl group" RELATED [ChEBI] xref: PDBeChem:OH is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:45696 name: hydrogensulfate namespace: chebi_ontology alt_id: CHEBI:29199 alt_id: CHEBI:45693 subset: 3_STAR synonym: "[SO3(OH)](-)" RELATED [IUPAC] synonym: "HSO4(-)" RELATED [IUPAC] synonym: "HYDROGEN SULFATE" RELATED [PDBeChem] synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogensulfate" EXACT [IUPAC] synonym: "hydrogensulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:2121 {source="Gmelin"} is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:46629 name: oxo group namespace: chebi_ontology alt_id: CHEBI:29353 alt_id: CHEBI:44607 subset: 3_STAR synonym: "=O" RELATED [IUPAC] synonym: "oxo" EXACT IUPAC_NAME [IUPAC] synonym: "OXO GROUP" EXACT [PDBeChem] xref: PDBeChem:O is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:46787 name: solvent namespace: chebi_ontology def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." [] subset: 3_STAR synonym: "Loesungsmittel" RELATED [ChEBI] synonym: "solvant" RELATED [ChEBI] synonym: "solvents" RELATED [ChEBI] xref: Wikipedia:Solvent is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:46883 name: carboxy group namespace: chebi_ontology alt_id: CHEBI:23025 alt_id: CHEBI:41420 subset: 3_STAR synonym: "-C(O)OH" RELATED [IUPAC] synonym: "-CO2H" RELATED [ChEBI] synonym: "-COOH" RELATED [IUPAC] synonym: "carboxy" EXACT IUPAC_NAME [IUPAC] synonym: "CARBOXY GROUP" EXACT [PDBeChem] synonym: "carboxyl group" RELATED [ChEBI] xref: PDBeChem:FMT is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:47622 name: acetate ester namespace: chebi_ontology alt_id: CHEBI:13244 alt_id: CHEBI:13799 alt_id: CHEBI:22189 alt_id: CHEBI:2406 def: "Any carboxylic ester where the carboxylic acid component is acetic acid." [] subset: 3_STAR synonym: "acetate" RELATED [ChEBI] synonym: "acetate esters" RELATED [ChEBI] synonym: "acetates" RELATED [ChEBI] synonym: "Acetic ester" RELATED [KEGG_COMPOUND] synonym: "Acetyl ester" RELATED [KEGG_COMPOUND] synonym: "acetyl esters" RELATED [ChEBI] synonym: "an acetyl ester" RELATED [UniProt] xref: KEGG:C01883 xref: Wikipedia:Acetate#Esters is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:15366 ! acetic acid [Term] id: CHEBI:47891 name: steroid acid namespace: chebi_ontology def: "Any steroid substituted by at least one carboxy group." [] subset: 3_STAR synonym: "steroid acids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:48154 name: sulfur oxide namespace: chebi_ontology subset: 3_STAR synonym: "oxides of sulfur" RELATED [ChEBI] synonym: "Schwefeloxide" RELATED [ChEBI] synonym: "sulfur oxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48354 name: polar solvent namespace: chebi_ontology def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." [] subset: 3_STAR synonym: "polar solvent" EXACT IUPAC_NAME [IUPAC] synonym: "polar solvents" RELATED [ChEBI] is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48356 name: protic solvent namespace: chebi_ontology def: "A polar solvent that is capable of acting as a hydron (proton) donor." [] subset: 3_STAR synonym: "protogenic solvent" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:39141 ! Bronsted acid is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48539 name: alpha-adrenergic drug namespace: chebi_ontology def: "Any drug that acts on an alpha-adrenergic receptor." [] subset: 3_STAR synonym: "alpha-adrenergic drugs" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent [Term] id: CHEBI:48705 name: agonist namespace: chebi_ontology def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." [] subset: 3_STAR synonym: "agonist" EXACT IUPAC_NAME [IUPAC] synonym: "agonista" RELATED [ChEBI] synonym: "agoniste" RELATED [ChEBI] synonym: "agonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:49637 name: hydrogen atom namespace: chebi_ontology alt_id: CHEBI:24634 alt_id: CHEBI:49636 subset: 3_STAR synonym: "1H" RELATED [IUPAC] synonym: "H" RELATED [IUPAC] synonym: "hidrogeno" RELATED [ChEBI] synonym: "hydrogen" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen" RELATED [ChEBI] synonym: "hydrogene" RELATED [ChEBI] synonym: "Wasserstoff" RELATED [ChEBI] xref: WebElements:H is_a: BFO:0000004 ! independent continuant is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33559 ! s-block element atom relationship: has_role CHEBI:33937 ! macronutrient [Term] id: CHEBI:50047 name: organic amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "organic amino compounds" RELATED [ChEBI] is_a: BFO:0000004 ! independent continuant is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:16134 ! ammonia relationship: has_role CHEBI:39142 ! Bronsted base [Term] id: CHEBI:50160 name: steroid acid anion namespace: chebi_ontology def: "Any anion formed by loss of a proton from a steroid acid." [] subset: 3_STAR synonym: "steroid acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid [Term] id: CHEBI:50297 name: canonical nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:50298 name: canonical deoxyribonucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical deoxyribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:50299 name: canonical ribonucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:50312 name: onium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:50313 name: onium cation namespace: chebi_ontology def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." [] subset: 3_STAR synonym: "onium cations" EXACT IUPAC_NAME [IUPAC] synonym: "onium cations" RELATED [ChEBI] synonym: "onium ion" RELATED [ChEBI] synonym: "onium ions" RELATED [ChEBI] is_a: CHEBI:50312 ! onium compound [Term] id: CHEBI:50319 name: nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleotide residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50320 name: nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleoside residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50514 name: vasoconstrictor agent namespace: chebi_ontology def: "Drug used to cause constriction of the blood vessels." [] subset: 3_STAR is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] subset: 3_STAR synonym: "organic compounds" RELATED [ChEBI] synonym: "organic entity" RELATED [ChEBI] synonym: "organic molecular entities" RELATED [ChEBI] is_a: CHEBI:33582 ! carbon group molecular entity relationship: has_part CHEBI:27594 ! carbon atom [Term] id: CHEBI:50906 name: role namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] subset: 3_STAR [Term] id: CHEBI:50910 name: neurotoxin namespace: chebi_ontology alt_id: CHEBI:50911 def: "A poison that interferes with the functions of the nervous system." [] subset: 3_STAR synonym: "agente neurotoxico" RELATED [ChEBI] synonym: "nerve poison" RELATED [ChEBI] synonym: "nerve poisons" RELATED [ChEBI] synonym: "neurotoxic agent" RELATED [ChEBI] synonym: "neurotoxic agents" RELATED [ChEBI] synonym: "neurotoxicant" RELATED [ChEBI] synonym: "neurotoxins" RELATED [ChEBI] xref: Wikipedia:Neurotoxin is_a: CHEBI:52209 ! aetiopathogenetic role is_a: CHEBI:64909 ! poison [Term] id: CHEBI:50994 name: primary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [] subset: 3_STAR synonym: "primary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion [Term] id: CHEBI:51086 name: chemical role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a chemical context." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:51143 name: nitrogen molecular entity namespace: chebi_ontology alt_id: CHEBI:25556 alt_id: CHEBI:7594 subset: 3_STAR synonym: "nitrogen compounds" RELATED [ChEBI] synonym: "nitrogen molecular entities" RELATED [ChEBI] synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND] xref: KEGG:C06061 is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:25555 ! nitrogen atom [Term] id: CHEBI:51151 name: dipolar compound namespace: chebi_ontology def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." [] subset: 3_STAR synonym: "dipolar compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:51422 name: organodiyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." [] subset: 3_STAR synonym: "organodiyl groups" RELATED [ChEBI] is_a: CHEBI:51446 ! organic divalent group [Term] id: CHEBI:51446 name: organic divalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51447 name: organic univalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51958 name: organic polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:52206 name: biochemical role namespace: chebi_ontology def: "A biological role played by the molecular entity or part thereof within a biochemical context." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52209 name: aetiopathogenetic role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." [] subset: 3_STAR synonym: "etiopathogenetic agent" RELATED [ChEBI] synonym: "etiopathogenetic role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52210 name: pharmacological role namespace: chebi_ontology def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52211 name: physiological role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52217 name: pharmaceutical namespace: chebi_ontology alt_id: CHEBI:33293 alt_id: CHEBI:33294 def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." [] subset: 3_STAR synonym: "farmaco" RELATED [ChEBI] synonym: "medicament" RELATED [ChEBI] synonym: "pharmaceuticals" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:52845 name: cyclic organic group namespace: chebi_ontology def: "An organic group that consists of a closed ring. It may be a substituent or a skeleton." [] subset: 3_STAR synonym: "cyclic organic groups" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:53000 name: epitope namespace: chebi_ontology def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." [] subset: 3_STAR synonym: "antigenic determinant" RELATED [ChEBI] synonym: "epitope function" RELATED [ChEBI] synonym: "epitope role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:53309 name: polyanionic macromolecule namespace: chebi_ontology def: "A polymer carrying multiple negative charges." [] subset: 3_STAR synonym: "polyanion" RELATED [ChEBI] synonym: "polyanions" RELATED [SUBMITTER] is_a: CHEBI:53368 ! ionic macromolecule [Term] id: CHEBI:53368 name: ionic macromolecule namespace: chebi_ontology def: "A macromolecule containing ionic groups." [] subset: 3_STAR synonym: "ionic polymer" RELATED [ChEBI] synonym: "polyionic macromolecule" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:5391 name: glucagon namespace: chebi_ontology def: "A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence." [] subset: 3_STAR synonym: "Glucagon" EXACT [KEGG_COMPOUND] synonym: "glucagon" RELATED INN [ChemIDplus] synonym: "Glucagone" RELATED [ChemIDplus] synonym: "glucagonum" RELATED INN [ChemIDplus] synonym: "His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr" RELATED [ChEBI] synonym: "His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr" RELATED [ChemIDplus] synonym: "HSQGTFTSDYSKYLDSRRAQDFVQWLMNT" RELATED [ChEBI] synonym: "L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine" EXACT IUPAC_NAME [IUPAC] xref: CAS:16941-32-5 {source="ChemIDplus"} xref: CAS:9007-92-5 {source="KEGG COMPOUND"} xref: CAS:9007-92-5 {source="ChemIDplus"} xref: Drug_Central:2994 {source="DrugCentral"} xref: DrugBank:DB00040 xref: KEGG:C01501 xref: KEGG:D00116 xref: PMID:21940356 {source="Europe PMC"} xref: PMID:22014161 {source="Europe PMC"} xref: PMID:22154917 {source="Europe PMC"} xref: PMID:22166985 {source="Europe PMC"} xref: PMID:22167521 {source="Europe PMC"} xref: PMID:22214853 {source="Europe PMC"} xref: PMID:22227186 {source="Europe PMC"} xref: PMID:22286080 {source="Europe PMC"} xref: PMID:22294753 {source="Europe PMC"} xref: PMID:22318544 {source="Europe PMC"} xref: PMID:22334714 {source="Europe PMC"} xref: PMID:22399501 {source="Europe PMC"} xref: PMID:22438981 {source="Europe PMC"} xref: PMID:22454291 {source="Europe PMC"} xref: Reaxys:13191924 {source="Reaxys"} xref: Wikipedia:Glucagon is_a: CHEBI:25905 ! peptide hormone [Term] id: CHEBI:5686 name: heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of at least two different elements." [] subset: 3_STAR synonym: "compuesto heterociclico" RELATED [IUPAC] synonym: "compuestos heterociclicos" RELATED [IUPAC] synonym: "heterocycle" RELATED [ChEBI] synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND] synonym: "heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:57887 name: tryptaminium namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "2-(1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "tryptamine" RELATED [UniProt] synonym: "tryptaminium cation" RELATED [ChEBI] synonym: "tryptaminium(1+)" RELATED [ChEBI] xref: Gmelin:533978 {source="Gmelin"} is_a: BFO:0000004 ! independent continuant is_a: CHEBI:65296 ! primary ammonium ion relationship: has_role CHEBI:75771 ! mouse metabolite relationship: has_role CHEBI:76924 ! plant metabolite relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:16765 ! tryptamine [Term] id: CHEBI:57977 name: bilirubin(2-) namespace: chebi_ontology def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." [] subset: 3_STAR synonym: "(4Z,15Z)-bilirubin IXalpha" RELATED [UniProt] synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate" RELATED [ChEBI] synonym: "bilirubin dianion" RELATED [ChEBI] xref: Beilstein:4083310 {source="Beilstein"} is_a: BFO:0000004 ! independent continuant is_a: CHEBI:28965 ! dicarboxylic acid dianion is_a: CHEBI:59252 ! linear tetrapyrrole anion relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:16990 ! bilirubin IXalpha [Term] id: CHEBI:58942 name: cationic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue protonated on nitrogen." [] subset: 3_STAR synonym: "amino acid cation residue" RELATED [ChEBI] synonym: "amino acid cation residues" RELATED [ChEBI] synonym: "amino-acid cation residue" RELATED [ChEBI] synonym: "amino-acid cation residues" RELATED [ChEBI] synonym: "cationic amino acid residue" RELATED [ChEBI] synonym: "cationic amino acid residues" RELATED [ChEBI] synonym: "cationic amino-acid residues" RELATED [ChEBI] is_a: CHEBI:64769 ! organic cationic group relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:58958 name: organosulfate oxoanion namespace: chebi_ontology def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." [] subset: 3_STAR synonym: "organosulfate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:33482 ! sulfur oxoanion relationship: has_functional_parent CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate [Term] id: CHEBI:59252 name: linear tetrapyrrole anion namespace: chebi_ontology def: "An organic anion arising from deprotonation of a acyclic tetrapyrrole compound." [] subset: 3_STAR synonym: "acyclic tetrapyrrole anion" RELATED [ChEBI] synonym: "acyclic tetrapyrrole anions" RELATED [ChEBI] synonym: "linear tetrapyrrole anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:59740 name: nucleophilic reagent namespace: chebi_ontology def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." [] subset: 3_STAR synonym: "nucleophile" RELATED [ChEBI] synonym: "nucleophiles" RELATED [ChEBI] synonym: "nucleophilic reagents" RELATED [ChEBI] is_a: CHEBI:33893 ! reagent is_a: CHEBI:39144 ! Lewis base [Term] id: CHEBI:59999 name: chemical substance namespace: chebi_ontology def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." [] subset: 3_STAR synonym: "Chemische Substanz" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:60004 name: mixture namespace: chebi_ontology def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." [] subset: 3_STAR synonym: "Mischung" RELATED [ChEBI] is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:60027 name: polymer namespace: chebi_ontology def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." [] subset: 3_STAR synonym: "Kunststoff" RELATED [ChEBI] synonym: "Polymer" EXACT [ChEBI] xref: Wikipedia:Polymer is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:33839 ! macromolecule [Term] id: CHEBI:60164 name: ionic polymer namespace: chebi_ontology def: "An ionic polymer is a polymer, composed of ionic macromolecules." [] subset: 3_STAR synonym: "polyionic polymer" RELATED [ChEBI] is_a: CHEBI:60027 ! polymer relationship: has_part CHEBI:53368 ! ionic macromolecule [Term] id: CHEBI:60242 name: monovalent inorganic cation namespace: chebi_ontology def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." [] subset: 3_STAR synonym: "a monovalent cation" RELATED [UniProt] is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:60466 name: peptide zwitterion namespace: chebi_ontology def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." [] subset: 3_STAR synonym: "a peptide" RELATED [UniProt] synonym: "peptide zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:16670 ! peptide [Term] id: CHEBI:61120 name: nucleobase-containing molecular entity namespace: chebi_ontology def: "Any compound that has a nucleobase as a part." [] subset: 3_STAR synonym: "nucleobase-containing compound" RELATED [SUBMITTER] synonym: "nucleobase-containing compounds" RELATED [ChEBI] synonym: "nucleobase-containing molecular entities" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_functional_parent CHEBI:18282 ! nucleobase [Term] id: CHEBI:61469 name: polyanionic polymer namespace: chebi_ontology def: "A polymer, composed of polyanion macromolecules." [] subset: 3_STAR synonym: "polyanion" RELATED [ChEBI] synonym: "polyanions" RELATED [ChEBI] is_a: CHEBI:60164 ! ionic polymer relationship: has_part CHEBI:53309 ! polyanionic macromolecule [Term] id: CHEBI:63248 name: oxidising agent namespace: chebi_ontology def: "A substance that removes electrons from another reactant in a redox reaction." [] subset: 3_STAR synonym: "oxidant" RELATED [ChEBI] synonym: "oxidants" RELATED [ChEBI] synonym: "oxidiser" RELATED [ChEBI] synonym: "oxidisers" RELATED [ChEBI] synonym: "oxidising agents" RELATED [ChEBI] synonym: "oxidizer" RELATED [ChEBI] synonym: "oxidizers" RELATED [ChEBI] synonym: "oxidizing agent" RELATED [ChEBI] synonym: "oxidizing agents" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63299 name: carbohydrate derivative namespace: chebi_ontology def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." [] subset: 3_STAR synonym: "carbohydrate derivatives" RELATED [ChEBI] synonym: "derivatised carbohydrate" RELATED [ChEBI] synonym: "derivatised carbohydrates" RELATED [ChEBI] synonym: "derivatized carbohydrate" RELATED [ChEBI] synonym: "derivatized carbohydrates" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives relationship: has_functional_parent CHEBI:16646 ! carbohydrate [Term] id: CHEBI:63436 name: carbohydrate acid derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a carbohydrate acid." [] subset: 3_STAR synonym: "carbohydrate acid derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:33720 ! carbohydrate acid relationship: is_conjugate_acid_of CHEBI:63551 ! carbohydrate acid derivative anion [Term] id: CHEBI:63534 name: monoamine namespace: chebi_ontology def: "An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes." [] subset: 3_STAR synonym: "monoamines" RELATED [ChEBI] synonym: "naturally occurring monoamine" RELATED [ChEBI] synonym: "naturally occurring monoamines" RELATED [ChEBI] xref: PMID:21822758 {source="Europe PMC"} xref: PMID:21993877 {source="Europe PMC"} xref: PMID:22005599 {source="Europe PMC"} xref: PMID:22082101 {source="Europe PMC"} xref: PMID:22153577 {source="Europe PMC"} xref: PMID:22213370 {source="Europe PMC"} xref: PMID:22218931 {source="Europe PMC"} xref: PMID:22342987 {source="Europe PMC"} xref: PMID:22371656 {source="Europe PMC"} is_a: CHEBI:64365 ! aralkylamino compound [Term] id: CHEBI:63551 name: carbohydrate acid derivative anion namespace: chebi_ontology def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." [] subset: 3_STAR synonym: "carbohydrate acid anion derivative" RELATED [ChEBI] synonym: "carbohydrate acid anion derivatives" RELATED [ChEBI] synonym: "carbohydrate acid derivative anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative [Term] id: CHEBI:64047 name: food additive namespace: chebi_ontology def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." [] subset: 3_STAR synonym: "food additives" RELATED [ChEBI] xref: Wikipedia:Food_additive is_a: CHEBI:33232 ! application is_a: CHEBI:78295 ! food component [Term] id: CHEBI:64049 name: food acidity regulator namespace: chebi_ontology def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." [] subset: 3_STAR synonym: "acidity regulator" RELATED [ChEBI] synonym: "acidity regulators" RELATED [ChEBI] synonym: "food acidity regulators" RELATED [ChEBI] synonym: "pH control agent" RELATED [ChEBI] synonym: "pH control agents" RELATED [ChEBI] xref: Wikipedia:Acidity_regulator is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64365 name: aralkylamino compound namespace: chebi_ontology def: "An organic amino compound in which an aminoalkyl group is linked to an arene." [] subset: 3_STAR synonym: "aralkylamino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:64628 name: somatostatin namespace: chebi_ontology def: "A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14." [] subset: 3_STAR synonym: "Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]" RELATED [ChEBI] synonym: "L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide" EXACT IUPAC_NAME [IUPAC] synonym: "L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide" RELATED [ChemIDplus] synonym: "somatostatin" RELATED INN [KEGG_DRUG] synonym: "Somatostatin-1" RELATED [KEGG_COMPOUND] synonym: "Somatostatin-14" RELATED [KEGG_COMPOUND] synonym: "somatostatina" RELATED INN [ChemIDplus] synonym: "somatostatine" RELATED INN [ChemIDplus] synonym: "somatostatinum" RELATED INN [ChemIDplus] synonym: "Synthetic growth hormone release-inhibiting hormone" RELATED [ChemIDplus] xref: CAS:38916-34-6 {source="KEGG DRUG"} xref: CAS:38916-34-6 {source="ChemIDplus"} xref: Drug_Central:2997 {source="DrugCentral"} xref: HMDB:HMDB0013072 xref: KEGG:C16022 xref: KEGG:D07431 xref: LINCS:LSM-5326 xref: PMID:21922516 {source="Europe PMC"} xref: PMID:22129035 {source="Europe PMC"} xref: PMID:22147011 {source="Europe PMC"} xref: PMID:22251942 {source="Europe PMC"} xref: PMID:22483686 {source="Europe PMC"} xref: PMID:22509294 {source="Europe PMC"} xref: Reaxys:10148626 {source="Reaxys"} xref: Wikipedia:Somatostatin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25905 ! peptide hormone [Term] id: CHEBI:64708 name: one-carbon compound namespace: chebi_ontology def: "An organic molecular entity containing a single carbon atom (C1)." [] subset: 3_STAR synonym: "one-carbon compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64709 name: organic acid namespace: chebi_ontology def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." [] subset: 3_STAR synonym: "organic acids" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64766 name: cationic group namespace: chebi_ontology def: "A group that carries an overall positive charge." [] subset: 3_STAR synonym: "cationic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64767 name: anionic group namespace: chebi_ontology def: "A group that carries an overall negative charge." [] subset: 3_STAR synonym: "anionic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64769 name: organic cationic group namespace: chebi_ontology def: "A cationic group that contains carbon." [] subset: 3_STAR synonym: "organic cationic groups" RELATED [ChEBI] is_a: CHEBI:64766 ! cationic group relationship: is_conjugate_acid_of CHEBI:33247 ! organic group [Term] id: CHEBI:64775 name: organic anionic group namespace: chebi_ontology def: "An anionic group that contains carbon." [] subset: 3_STAR synonym: "organic anionic groups" RELATED [ChEBI] is_a: CHEBI:64767 ! anionic group relationship: is_conjugate_base_of CHEBI:33247 ! organic group [Term] id: CHEBI:64898 name: anionic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue carrying an overall negative charge." [] subset: 3_STAR synonym: "amino acid anion residue" RELATED [ChEBI] synonym: "amino acid anion residues" RELATED [ChEBI] synonym: "amino-acid anion residue" RELATED [ChEBI] synonym: "amino-acid anion residues" RELATED [ChEBI] synonym: "anionic amino acid residue" RELATED [ChEBI] synonym: "anionic amino acid residues" RELATED [ChEBI] synonym: "anionic amino-acid residues" RELATED [ChEBI] is_a: CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:64909 name: poison namespace: chebi_ontology def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." [] subset: 3_STAR synonym: "poisonous agent" RELATED [ChEBI] synonym: "poisonous agents" RELATED [ChEBI] synonym: "poisonous substance" RELATED [ChEBI] synonym: "poisonous substances" RELATED [ChEBI] synonym: "poisons" RELATED [ChEBI] synonym: "toxic agent" RELATED [ChEBI] synonym: "toxic agents" RELATED [ChEBI] synonym: "toxic substance" RELATED [ChEBI] synonym: "toxic substances" RELATED [ChEBI] xref: Wikipedia:Poison is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:65212 name: polysaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is any derivative of a polysaccharide." [] subset: 3_STAR synonym: "polysaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:18154 ! polysaccharide [Term] id: CHEBI:65255 name: food preservative namespace: chebi_ontology def: "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." [] subset: 3_STAR synonym: "food preservatives" RELATED [ChEBI] is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:65256 name: antimicrobial food preservative namespace: chebi_ontology def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." [] subset: 3_STAR synonym: "antimicrobial food preservatives" RELATED [ChEBI] synonym: "antimicrobial preservative" RELATED [ChEBI] synonym: "antimicrobial preservatives" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:65255 ! food preservative [Term] id: CHEBI:65296 name: primary ammonium ion namespace: chebi_ontology def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." [] subset: 3_STAR synonym: "a primary amine" RELATED [UniProt] synonym: "substituted ammonium" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound [Term] id: CHEBI:67079 name: anti-inflammatory agent namespace: chebi_ontology def: "Any compound that has anti-inflammatory effects." [] subset: 3_STAR synonym: "anti-inflammatory agents" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:72587 name: (R)-noradrenaline(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-noradrenaline" RELATED [UniProt] synonym: "(R)-noradrenaline cation" RELATED [ChEBI] synonym: "(R)-noradrenalinium cation" RELATED [ChEBI] synonym: "(R)-noradrenalinium(1+)" RELATED [ChEBI] xref: PDBeChem:E5E is_a: BFO:0000004 ! independent continuant is_a: CHEBI:166902 ! noradrenaline(1+) relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_acid_of CHEBI:18357 ! (R)-noradrenaline [Term] id: CHEBI:72695 name: organic molecule namespace: chebi_ontology def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." [] subset: 3_STAR synonym: "organic compound" RELATED [ChEBI] synonym: "organic compounds" RELATED [ChEBI] synonym: "organic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72813 name: exopolysaccharide namespace: chebi_ontology def: "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." [] subset: 3_STAR synonym: "exopolysaccharides" RELATED [ChEBI] synonym: "extracellular polymeric substance" RELATED [ChEBI] synonym: "extracellular polymeric substances" RELATED [ChEBI] xref: MetaCyc:Exopolysaccharides xref: PMID:11160795 {source="Europe PMC"} xref: PMID:11785425 {source="Europe PMC"} xref: PMID:1444258 {source="Europe PMC"} xref: PMID:15738217 {source="Europe PMC"} xref: PMID:16075348 {source="Europe PMC"} xref: PMID:17440912 {source="Europe PMC"} xref: PMID:18097339 {source="Europe PMC"} xref: PMID:19453747 {source="Europe PMC"} xref: PMID:20172021 {source="Europe PMC"} xref: PMID:20631870 {source="Europe PMC"} xref: PMID:20718297 {source="Europe PMC"} xref: PMID:2688547 {source="Europe PMC"} xref: PMID:6354590 {source="Europe PMC"} xref: Wikipedia:Exopolysaccharide xref: Wikipedia:Extracellular_polymeric_substance is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:73398 name: indole skeleton namespace: chebi_ontology def: "A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring." [] subset: 3_STAR is_a: CHEBI:73541 ! organic heterobicyclic ring [Term] id: CHEBI:73541 name: organic heterobicyclic ring namespace: chebi_ontology def: "A bicyclic organic group that contains both carbon and hetero atoms." [] subset: 3_STAR synonym: "organic heterobicyclic rings" RELATED [ChEBI] is_a: CHEBI:52845 ! cyclic organic group [Term] id: CHEBI:75763 name: eukaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." [] subset: 3_STAR synonym: "eukaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75767 name: animal metabolite namespace: chebi_ontology alt_id: CHEBI:77721 alt_id: CHEBI:77743 def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." [] subset: 3_STAR synonym: "animal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:75768 name: mammalian metabolite namespace: chebi_ontology alt_id: CHEBI:77464 alt_id: CHEBI:77744 def: "Any animal metabolite produced during a metabolic reaction in mammals." [] subset: 3_STAR synonym: "mammalian metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:75771 name: mouse metabolite namespace: chebi_ontology def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." [] subset: 3_STAR synonym: "mouse metabolites" RELATED [ChEBI] synonym: "Mus musculus metabolite" RELATED [ChEBI] synonym: "Mus musculus metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:75772 name: Saccharomyces cerevisiae metabolite namespace: chebi_ontology alt_id: CHEBI:76949 alt_id: CHEBI:76951 def: "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." [] subset: 3_STAR synonym: "baker's yeast metabolite" RELATED [ChEBI] synonym: "baker's yeast metabolites" RELATED [ChEBI] synonym: "baker's yeast secondary metabolite" RELATED [ChEBI] synonym: "baker's yeast secondary metabolites" RELATED [ChEBI] synonym: "S. cerevisiae metabolite" RELATED [ChEBI] synonym: "S. cerevisiae metabolites" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:75787 name: prokaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." [] subset: 3_STAR synonym: "prokaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76206 name: xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound." [] subset: 3_STAR synonym: "xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor namespace: chebi_ontology def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." [] subset: 3_STAR synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.* inhibitors" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI] synonym: "hydrolase inhibitor" RELATED [ChEBI] synonym: "hydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Hydrolase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76764 name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor namespace: chebi_ontology def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." [] subset: 3_STAR synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76807 name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." [] subset: 3_STAR synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76924 name: plant metabolite namespace: chebi_ontology alt_id: CHEBI:75766 alt_id: CHEBI:76925 def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." [] subset: 3_STAR synonym: "plant metabolites" RELATED [ChEBI] synonym: "plant secondary metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76946 name: fungal metabolite namespace: chebi_ontology alt_id: CHEBI:75765 alt_id: CHEBI:76947 def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." [] subset: 3_STAR synonym: "fungal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76967 name: human xenobiotic metabolite namespace: chebi_ontology def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." [] subset: 3_STAR synonym: "human xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:76969 name: bacterial metabolite namespace: chebi_ontology alt_id: CHEBI:75760 alt_id: CHEBI:76970 def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." [] subset: 3_STAR is_a: CHEBI:75787 ! prokaryotic metabolite [Term] id: CHEBI:76971 name: Escherichia coli metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." [] subset: 3_STAR synonym: "E.coli metabolite" RELATED [ChEBI] synonym: "E.coli metabolites" RELATED [ChEBI] synonym: "Escherichia coli metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:77746 name: human metabolite namespace: chebi_ontology alt_id: CHEBI:75770 alt_id: CHEBI:77123 def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." [] subset: 3_STAR synonym: "H. sapiens metabolite" RELATED [ChEBI] synonym: "H. sapiens metabolites" RELATED [ChEBI] synonym: "Homo sapiens metabolite" RELATED [ChEBI] synonym: "Homo sapiens metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:77941 name: EC 3.5.1.4 (amidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." [] subset: 3_STAR synonym: "acylamidase inhibitor" RELATED [ChEBI] synonym: "acylamidase inhibitors" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI] synonym: "amidase inhibitor" RELATED [ChEBI] synonym: "amidase inhibitors" RELATED [ChEBI] synonym: "amidohydrolase inhibitor" RELATED [ChEBI] synonym: "amidohydrolase inhibitors" RELATED [ChEBI] synonym: "deaminase inhibitor" RELATED [ChEBI] synonym: "deaminase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI] synonym: "fatty acylamidase inhibitor" RELATED [ChEBI] synonym: "fatty acylamidase inhibitors" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Amidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:77974 name: food packaging gas namespace: chebi_ontology def: "A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container." [] subset: 3_STAR synonym: "food packaging gases" RELATED [ChEBI] xref: Wikipedia:Packaging_gas is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:78295 name: food component namespace: chebi_ontology def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." [] subset: 3_STAR synonym: "dietary component" RELATED [ChEBI] synonym: "dietary components" RELATED [ChEBI] synonym: "food components" RELATED [ChEBI] is_a: CHEBI:52211 ! physiological role [Term] id: CHEBI:78433 name: refrigerant namespace: chebi_ontology def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." [] subset: 3_STAR synonym: "refrigerants" RELATED [ChEBI] xref: Wikipedia:Refrigerant is_a: CHEBI:33232 ! application [Term] id: CHEBI:78608 name: alpha-amino acid zwitterion namespace: chebi_ontology alt_id: CHEBI:83409 def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." [] subset: 3_STAR synonym: "an alpha-amino acid" RELATED [UniProt] xref: MetaCyc:Alpha-Amino-Acids {source="SUBMITTER"} is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives namespace: chebi_ontology def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." [] subset: 3_STAR synonym: "carbohydrates and derivatives" RELATED [ChEBI] synonym: "carbohydrates and their derivatives" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:78675 name: fundamental metabolite namespace: chebi_ontology def: "Any metabolite produced by all living cells." [] subset: 3_STAR synonym: "essential metabolite" RELATED [ChEBI] synonym: "essential metabolites" RELATED [ChEBI] synonym: "fundamental metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:79388 name: divalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of two." [] subset: 3_STAR synonym: "divalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79389 name: monovalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of one." [] subset: 3_STAR synonym: "monovalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:83039 name: crustacean metabolite namespace: chebi_ontology def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." [] subset: 3_STAR synonym: "crustacean metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:83056 name: Daphnia magna metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia magna." [] subset: 3_STAR synonym: "Daphnia magna metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83057 name: Daphnia metabolite namespace: chebi_ontology def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" [] subset: 3_STAR synonym: "Daphnia metabolites" RELATED [ChEBI] xref: Wikipedia:Daphnia is_a: CHEBI:83039 ! crustacean metabolite [Term] id: CHEBI:84729 name: hydroxyindoles namespace: chebi_ontology def: "Any member of the class of indoles carrying at least one hydroxy group." [] subset: 3_STAR is_a: CHEBI:24828 ! indoles is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: cellxgene_subset subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="has_characteristic"} ! nucleus relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="has_characteristic"} ! nucleus relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: CL:0000005 name: neural crest derived fibroblast def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] synonym: "fibroblast neural crest derived" EXACT [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] subset: cellxgene_subset synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell (metazoa) def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] synonym: "germline stem cell" EXACT [] is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] subset: cellxgene_subset xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0048477 ! oogenesis relationship: capable_of GO:0048477 ! oogenesis [Term] id: CL:0000022 name: female germ line stem cell def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FMA:18644 xref: MESH:D009865 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000255 ! eukaryotic cell relationship: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: participates_in GO:0007143 ! female meiotic nuclear division [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset xref: FMA:83673 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: capable_of GO:0000278 ! mitotic cell cycle relationship: capable_of GO:0000278 ! mitotic cell cycle relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FMA:67343 xref: MESH:D010063 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte relationship: participates_in GO:0007143 ! female meiotic nuclear division property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Egg_cell.svg xsd:anyURI [Term] id: CL:0000027 name: smooth muscle cell neural crest derived def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] synonym: "neuron neural crest derived" EXACT [] is_a: CL:0000540 {is_inferred="true"} ! neuron is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] subset: cellxgene_subset synonym: "neuroblast" EXACT [] xref: BTO:0000930 xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division relationship: capable_of GO:0017145 ! stem cell division relationship: in_taxon NCBITaxon:33208 ! Metazoa property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division intersection_of: has_characteristic PATO:0001400 ! unipotent relationship: has_characteristic PATO:0001400 ! unipotent [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" RELATED OMO:0003000 [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:86475 xref: MESH:D006412 xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: capable_of GO:0048103 ! somatic stem cell division intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: general_cell_types_upper_slim subset: ubprop:upper_level is_a: CL:0000000 ! cell relationship: capable_of GO:0022414 ! reproductive process [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division intersection_of: has_characteristic PATO:0001402 ! multipotent relationship: has_characteristic PATO:0001402 ! multipotent [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: capable_of GO:0030219 ! megakaryocyte differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000052 name: totipotent stem cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000055 name: non-terminally differentiated cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? subset: cellxgene_subset synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0011115 ! precursor cell [Term] id: CL:0000056 name: myoblast def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: NCIT:C12482 xref: VHOG:0001482 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000058 name: chondroblast def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast relationship: produces UBERON:0002418 ! cartilage tissue [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] subset: cellxgene_subset xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: has_part GO:0005929 ! cilium relationship: has_part GO:0005929 ! cilium [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000000 ! cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Epithelial_cells.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cilia." [GOC:tfm] subset: cellxgene_subset xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: has_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct [Term] id: CL:0000069 name: branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001981 ! blood vessel relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell relationship: part_of UBERON:0004638 ! blood vessel endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000066 ! epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000076 name: squamous epithelial cell subset: cellxgene_subset xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] subset: cellxgene_subset subset: general_cell_types_upper_slim xref: FMA:62844 xref: MESH:D001773 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0008015 ! blood circulation relationship: capable_of GO:0008015 ! blood circulation [Term] id: CL:0000082 name: epithelial cell of lung def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000115 ! lung epithelium relationship: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:0000083 name: epithelial cell of pancreas def: "An epithelial cell of the pancreas." [GOC:tfm] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000095 name: neuron associated cell subset: cellxgene_subset is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0003811 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:0000540 ! neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] subset: cellxgene_subset subset: human_reference_atlas synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] subset: human_reference_atlas xref: BTO:0001037 xref: FMA:84649 xref: MESH:D011984 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000107 name: autonomic neuron def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: has_soma_location UBERON:0002410 ! autonomic nervous system relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_soma_location UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 xref: MESH:D059329 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. subset: cellxgene_subset subset: human_reference_atlas synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000222 ! mesodermal cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) is_a: CL:0000540 ! neuron is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. subset: cellxgene_subset synonym: "BMSC" RELATED OMO:0003000 [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED OMO:0003000 [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED OMO:0003004 [] synonym: "MSC" RELATED OMO:0003000 [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/474 xsd:string [Term] id: CL:0000136 name: adipocyte def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "adipose cell" EXACT [] synonym: "fat cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000138 name: chondrocyte def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] subset: cellxgene_subset synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast relationship: located_in UBERON:0002418 ! cartilage tissue [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000149 name: visual pigment cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] subset: cellxgene_subset xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0006799 ! glandular epithelium [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0032940 ! secretion by cell relationship: capable_of GO:0032940 ! secretion by cell [Term] id: CL:0000152 name: exocrine cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] subset: general_cell_types_upper_slim xref: FMA:16014 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: part_of UBERON:0002365 ! exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0009306 ! protein secretion relationship: capable_of GO:0009306 ! protein secretion [Term] id: CL:0000159 name: seromucus secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000164 {gci_relation="part_of", gci_filler="UBERON:0000945"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="part_of"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="part_of"} ! enteroendocrine cell relationship: part_of UBERON:0000949 ! endocrine system property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000164 name: enteroendocrine cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] subset: cellxgene_subset xref: BTO:0003865 xref: FMA:62930 xref: MESH:D019858 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} subset: cellxgene_subset subset: human_reference_atlas synonym: "neurosecretory cell" RELATED [] synonym: "neurosecretory neuron" RELATED [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0046879 ! hormone secretion property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000167 name: peptide hormone secreting cell def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030072 ! peptide hormone secretion relationship: capable_of GO:0030072 ! peptide hormone secretion [Term] id: CL:0000168 name: insulin secreting cell def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated] xref: BTO:0000783 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0030073 ! insulin secretion relationship: capable_of GO:0030073 ! insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. subset: cellxgene_subset subset: human_reference_atlas synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0030073 ! insulin secretion intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000170 name: glucagon secreting cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070091 ! glucagon secretion relationship: capable_of GO:0070091 ! glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas synonym: "alpha cell of islet of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 xref: MESH:D050416 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000172 name: somatostatin secreting cell def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070253 ! somatostatin secretion relationship: capable_of GO:0070253 ! somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000174 name: steroid hormone secreting cell def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035929 ! steroid hormone secretion relationship: capable_of GO:0035929 ! steroid hormone secretion [Term] id: CL:0000182 name: hepatocyte def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 is_a: CL:0000066 ! epithelial cell is_a: CL:0000417 ! endopolyploid cell is_a: UBERON:0004119 ! endoderm-derived structure relationship: capable_of GO:0006699 ! bile acid biosynthetic process relationship: capable_of GO:0098754 ! detoxification relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002107 ! liver property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [FB:ma] subset: cellxgene_subset is_a: CL:0000000 ! cell [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] subset: cellxgene_subset synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: develops_from CL:0000056 ! myoblast property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Muscle_cells.svg xsd:anyURI [Term] id: CL:0000188 name: cell of skeletal muscle def: "A somatic cell located in skeletal muscle." [GOC:tfm] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0000000 ! cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000192 name: smooth muscle cell def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" BROAD [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] synonym: "receptor cell" EXACT [] xref: MESH:D011984 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: part_of UBERON:0001032 ! sensory system relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception relationship: part_of UBERON:0001032 ! sensory system [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized to detect and transduce light." [MESH:D010786] subset: cellxgene_subset xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FMA:86740 is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg xsd:anyURI [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000213 name: lining cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] synonym: "synoviocyte" EXACT [] xref: CALOHA:TS-0995 is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell relationship: part_of UBERON:0002217 ! synovial joint [Term] id: CL:0000215 name: barrier cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0048870 ! cell motility relationship: capable_of GO:0048870 ! cell motility [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [MESH:D008648] subset: cellxgene_subset synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000225 name: anucleate cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001405 ! anucleate disjoint_from: CL:0002242 ! nucleate cell relationship: has_characteristic PATO:0001405 ! anucleate [Term] id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001407 ! mononucleate relationship: has_characteristic PATO:0001407 ! mononucleate [Term] id: CL:0000227 name: binucleate cell def: "Any cell that has characteristic some binucleate." [FBC:Autogenerated] is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001406 ! binucleate relationship: has_characteristic PATO:0001406 ! binucleate [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] xref: AEO:0000203 xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001908 ! multinucleate relationship: has_characteristic PATO:0001908 ! multinucleate [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0008015 ! blood circulation intersection_of: capable_of GO:0015671 ! oxygen transport intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: has_characteristic PATO:0002039 ! biconcave relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: develops_from CL:0000558 ! reticulocyte relationship: has_characteristic PATO:0002039 ! biconcave property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000255 name: eukaryotic cell def: "Any cell that only exists in Eukaryota." [FBC:Autogenerated] subset: cellxgene_subset xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: only_in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: CL:0000257 name: Eumycetozoan cell def: "Any cell that only exists in Eumycetozoa." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: only_in_taxon NCBITaxon:142796 ! Eumycetozoa relationship: only_in_taxon NCBITaxon:142796 ! Eumycetozoa [Term] id: CL:0000287 name: eye photoreceptor cell def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000293 name: structural cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000000 ! cell [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0009566 ! fertilization intersection_of: has_characteristic PATO:0001375 ! haploid relationship: capable_of GO:0009566 ! fertilization [Term] id: CL:0000306 name: crystallin accumulating cell subset: eye_upper_slim synonym: "lens cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000313 name: serous secreting cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] subset: cellxgene_subset synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000319 name: mucus secreting cell def: "Any secretory cell that is capable of some mucus secretion." [FBC:Autogenerated] subset: cellxgene_subset synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0070254 ! mucus secretion relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: ubprop:upper_level is_a: CL:0000000 ! cell [Term] id: CL:0000327 name: extracellular matrix secreting cell is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0015671 ! oxygen transport relationship: capable_of GO:0015671 ! oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000347 name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] subset: eye_upper_slim is_a: CL:0000293 ! structural cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye def: "A structural cell that is part of optic choroid." [GOC:add] subset: eye_upper_slim is_a: CL:0000293 ! structural cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] subset: general_cell_types_upper_slim is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:D014327] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 name: epiblast cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. xref: FMA:86767 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000358 name: sphincter associated smooth muscle cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000362 name: epidermal cell def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] subset: cellxgene_subset synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelium relationship: part_of UBERON:0007376 ! outer epithelium [Term] id: CL:0000365 name: animal zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] synonym: "zygote" BROAD [] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: has_soma_location UBERON:0000045 ! ganglion relationship: has_soma_location UBERON:0000045 ! ganglion [Term] id: CL:0000402 name: CNS interneuron def: "An interneuron that has its cell body in a central nervous system." [doi:10.1016/B978-0-12-817424-1.00001-X] comment: Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. subset: human_reference_atlas is_a: CL:0000099 ! interneuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000099 ! interneuron intersection_of: has_soma_location UBERON:0001017 ! central nervous system property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000412 name: polyploid cell def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001377 ! polyploid relationship: has_characteristic PATO:0001377 ! polyploid [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0001375 ! haploid relationship: has_characteristic PATO:0001375 ! haploid [Term] id: CL:0000417 name: endopolyploid cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000447 name: carbohydrate secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000457 name: biogenic amine secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0001820 ! serotonin secretion relationship: capable_of GO:0001820 ! serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0048243 ! norepinephrine secretion relationship: capable_of GO:0048243 ! norepinephrine secretion [Term] id: CL:0000488 name: visible light photoreceptor cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: capable_of GO:0009584 ! detection of visible light relationship: capable_of GO:0009584 ! detection of visible light [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:D017154] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000502 name: type D enteroendocrine cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] subset: cellxgene_subset synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863] subset: cellxgene_subset synonym: "G cell" EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum [Term] id: CL:0000509 name: gastrin secreting cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] subset: human_reference_atlas is_a: CL:0000167 ! peptide hormone secreting cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000513 name: cardiac muscle myoblast def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] subset: cellxgene_subset synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue relationship: part_of UBERON:0001133 ! cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] subset: cellxgene_subset synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000192 ! smooth muscle cell relationship: develops_into CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 ! myoblast is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell relationship: develops_into CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000521 name: fungal cell def: "Any cell that only exists in Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: only_in_taxon NCBITaxon:4751 ! Fungi relationship: only_in_taxon NCBITaxon:4751 ! Fungi [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_reference_atlas synonym: "plasmidotrophoblast cell" RELATED [] synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: has_characteristic PATO:0001908 ! multinucleate relationship: part_of UBERON:0000371 ! syncytiotrophoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/2100 xsd:string [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] subset: human_reference_atlas synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) property_value: http://xmlns.com/foaf/0.1/depiction https://www.swissbiopics.org/api/image/Neuron_cells.svg xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_characteristic PATO:0002505 ! nucleated intersection_of: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio intersection_of: has_part CL:0017503 ! basophilic cytoplasm intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio relationship: has_part CL:0017503 ! basophilic cytoplasm relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017503 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: has_part CL:0017503 ! basophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017504 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CL:0017504 ! polychromatophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017502 ! acidophilic cytoplasm intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CL:0017502 ! acidophilic cytoplasm relationship: participates_in GO:0030263 ! apoptotic chromosome condensation [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. subset: cellxgene_subset subset: human_reference_atlas synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: capable_of GO:0007113 ! endomitotic cell cycle intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: capable_of GO:0007113 ! endomitotic cell cycle relationship: capable_of GO:0030219 ! megakaryocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000556 name: megakaryocyte def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell relationship: has_characteristic PATO:0001393 ! euploid property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] subset: blood_and_immune_upper_slim subset: cellxgene_subset xref: BTO:0001173 xref: CALOHA:TS-0864 xref: MESH:D012156 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0071971 ! extracellular exosome assembly intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: capable_of GO:0071971 ! extracellular exosome assembly relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: has_characteristic PATO:0002505 ! nucleated relationship: develops_from CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000566 name: angioblastic mesenchymal cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5 intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 relationship: develops_from CL:0000134 ! mesenchymal stem cell relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5 relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] subset: cellxgene_subset is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: develops_into CL:0002494 ! cardiocyte relationship: develops_into CL:0002494 ! cardiocyte [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] subset: cellxgene_subset subset: human_reference_atlas synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000575 name: corneal epithelial cell def: "An epithelial cell of the cornea." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0001772 ! corneal epithelium relationship: part_of UBERON:0001772 ! corneal epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [MESH:D005854] subset: cellxgene_subset xref: BTO:0000535 xref: NCIT:C12597 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: capable_of_part_of GO:0009566 ! fertilization [Term] id: CL:0000593 name: androgen secreting cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035935 ! androgen secretion relationship: capable_of GO:0035935 ! androgen secretion [Term] id: CL:0000595 name: enucleate erythrocyte def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] subset: cellxgene_subset synonym: "RBC" RELATED OMO:0003000 [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 {is_inferred="true"} ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: has_characteristic PATO:0001405 ! anucleate relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] subset: cellxgene_subset subset: human_reference_atlas synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] subset: cellxgene_subset synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 xref: MESH:D061354 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: part_of UBERON:0009842 ! glandular acinus [Term] id: CL:0000630 name: supporting cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] subset: cellxgene_subset synonym: "supportive cell" EXACT [] xref: BTO:0002315 is_a: CL:0000000 ! cell [Term] id: CL:0000666 name: fenestrated endothelial cell def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] subset: cellxgene_subset synonym: "window cell" EXACT [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: has_characteristic PATO:0002064 ! fenestrated relationship: has_characteristic PATO:0002064 ! fenestrated [Term] id: CL:0000667 name: collagen secreting cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] subset: cellxgene_subset is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] subset: cellxgene_subset synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: capable_of GO:0048870 ! cell motility intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000680 name: muscle precursor cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] subset: cellxgene_subset is_a: CL:0000055 ! non-terminally differentiated cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0011115 ! precursor cell intersection_of: develops_into CL:0000187 ! muscle cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_into CL:0000187 ! muscle cell [Term] id: CL:0000696 name: PP cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] subset: cellxgene_subset synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: MESH:D053687 is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: capable_of GO:0048103 ! somatic stem cell division relationship: capable_of GO:0048103 ! somatic stem cell division [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: has_characteristic PATO:0001410 ! striated intersection_of: has_part GO:0030017 ! sarcomere disjoint_from: CL:0008000 ! non-striated muscle cell relationship: has_characteristic PATO:0001410 ! striated relationship: has_part GO:0030017 ! sarcomere [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] subset: cellxgene_subset subset: human_reference_atlas synonym: "immune cell" RELATED [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 xref: MESH:D007962 xref: NCIT:C12529 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration intersection_of: has_characteristic PATO:0002505 ! nucleated relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002405 ! immune system property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] xref: BTO:0001800 xref: FMA:67765 xref: MESH:D012165 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: has_soma_location UBERON:0000966 ! retina property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000746 name: cardiac muscle cell alt_id: FMA:83808 def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: has_characteristic PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0007100 ! primary circulatory organ intersection_of: participates_in GO:0060047 ! heart contraction relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: has_characteristic PATO:0002478 ! transversely striated relationship: participates_in GO:0060047 ! heart contraction property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] subset: cellxgene_subset xref: BTO:0001441 xref: CALOHA:TS-0647 xref: MESH:D022423 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. subset: cellxgene_subset subset: human_reference_atlas synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 xref: MESH:D004900 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_part GO:0005634 ! nucleus relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part GO:0005634 ! nucleus [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] subset: cellxgene_subset is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: has_characteristic PATO:0001402 ! multipotent intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: has_characteristic PATO:0001402 ! multipotent relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_reference_atlas synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: capable_of GO:0030099 ! myeloid cell differentiation relationship: capable_of GO:0030099 ! myeloid cell differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000842 name: mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] subset: blood_and_immune_upper_slim subset: cellxgene_subset synonym: "mononuclear leukocyte" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: has_characteristic PATO:0001407 ! mononucleate [Term] id: CL:0000850 name: serotonergic neuron def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: MESH:D059326 xref: WBbt:0006837 is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] subset: cellxgene_subset synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000000 ! cell [Term] id: CL:0001035 name: bone cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] subset: general_cell_types_upper_slim subset: human_reference_atlas is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9990-8331 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: has_characteristic PATO:0001401 ! oligopotent relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] subset: cellxgene_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: capable_of GO:0030218 ! erythrocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] subset: blood_and_immune_upper_slim is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: has_characteristic PATO:0001400 ! unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: has_characteristic PATO:0001400 ! unipotent property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). subset: blood_and_immune_upper_slim is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: has_characteristic PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell relationship: has_characteristic PATO:0001401 ! oligopotent property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002064 name: pancreatic acinar cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] subset: cellxgene_subset subset: human_reference_atlas synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 ! zymogen granule membrane relationship: part_of UBERON:0001263 ! pancreatic acinus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002067 name: type A enteroendocrine cell def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: capable_of GO:0070091 ! glucagon secretion property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] subset: human_reference_atlas synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000223 ! endodermal cell relationship: develops_from CL:0000223 ! endodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000221 ! ectodermal cell relationship: develops_from CL:0000221 ! ectodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000222 ! mesodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:63099 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001064 ! ventral pancreatic duct property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] subset: human_reference_atlas synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001263 ! pancreatic acinus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [GOC:tfm] subset: blood_and_immune_upper_slim synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. subset: cellxgene_subset subset: human_reference_atlas synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction relationship: capable_of GO:0043134 ! regulation of hindgut contraction property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. subset: cellxgene_subset xref: BTO:0004850 xref: FMA:83621 xref: MESH:D001854 is_a: CL:0001035 {is_inferred="true"} ! bone cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002095 name: hilus cell of ovary def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] subset: human_reference_atlas synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [GOC:tfm] subset: cellxgene_subset synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. subset: cellxgene_subset synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002144 name: capillary endothelial cell def: "An endothelial cell found in capillaries." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002178 name: epithelial cell of stomach def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002180 name: mucous cell of stomach def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: part_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002183 name: stem cell of gastric gland def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] subset: eye_upper_slim xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0000965 ! lens of camera-type eye property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002224 name: lens epithelial cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: has_characteristic PATO:0002505 ! nucleated relationship: has_characteristic PATO:0002505 ! nucleated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] subset: cellxgene_subset synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002246 name: peripheral blood stem cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 xref: MESH:D000072916 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus def: "An epithelial cell of the esophagus." [GOC:tfm] subset: cellxgene_subset xref: FMA:63071 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine def: "An epithelial cell of the large intestine." [GOC:tfm] subset: cellxgene_subset synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine def: "An epithelial cell of the small intestine." [GOC:tfm] subset: cellxgene_subset xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002262 name: endothelial cell of sinusoid def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:63134 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002264 name: type A cell of stomach def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon def: "A D cell located in the colon." [GOC:tfm] synonym: "colon D-cell" EXACT [] synonym: "colonic delta cell" EXACT [] synonym: "delta cell of colon" EXACT [] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009042 ! enteroendocrine cell of colon intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine def: "A type D cell of the small intestine." [GOC:tfm] synonym: "delta cell of small intestine" EXACT [] synonym: "small intestine D-cell" EXACT [] synonym: "small intestine delta cell" EXACT [] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009006 ! enteroendocrine cell of small intestine intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach def: "A type D cell found in the stomach." [GOC:tfm] synonym: "delta cell of stomach" EXACT [] synonym: "stomach D-cell" EXACT [] synonym: "stomach delta cell" EXACT [] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002275 name: pancreatic PP cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. subset: cellxgene_subset subset: human_reference_atlas synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 xref: MESH:D050418 is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002308 name: epithelial cell of skin gland def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset xref: CALOHA:TS-2096 xref: FMA:63875 xref: MESH:D003239 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell (metazoa) def: "A cell of the embryo." [FMA:0618947256] xref: CALOHA:TS-0263 xref: FMA:82840 xref: WBbt:0007028 is_a: CL:0000000 ! cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002333 name: neural crest derived adipocyte def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! adipocyte is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000136 ! adipocyte intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000005 ! neural crest derived fibroblast property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002350 name: endocardial cell def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] subset: cellxgene_subset subset: human_reference_atlas synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667] subset: cellxgene_subset synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0011026 ! progenitor cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002368 name: respiratory epithelial cell def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] subset: cellxgene_subset synonym: "airway epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium relationship: part_of UBERON:0004802 ! respiratory tract epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002372 name: myotube def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: has_characteristic PATO:0001908 ! multinucleate intersection_of: has_characteristic PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere relationship: has_characteristic PATO:0002478 ! transversely striated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: has_characteristic PATO:0002505 ! nucleated property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] subset: cellxgene_subset xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 {is_inferred="true"} ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: has_characteristic PATO:0001405 ! anucleate intersection_of: has_part GO:0005840 ! ribosome relationship: has_part GO:0005840 ! ribosome property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002494 name: cardiocyte def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0007100 ! primary circulatory organ relationship: part_of UBERON:0007100 ! primary circulatory organ property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002503 name: adventitial cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] subset: cellxgene_subset xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0005742 ! adventitia relationship: part_of UBERON:0005742 ! adventitia property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell def: "A smooth muscle cell of the intestine." [GOC:tfm] subset: cellxgene_subset synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002521 name: subcutaneous adipocyte def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "subcutaneous fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! adipocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000136 ! adipocyte intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002538 name: intrahepatic cholangiocyte def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] subset: cellxgene_subset synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296] is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell def: "A smooth muscle cell of the aorta." [GOC:tfm] subset: cellxgene_subset xref: BTO:0004577 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002543 name: vein endothelial cell def: "An endothelial cell that is part of the vein." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:20:39Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia relationship: part_of UBERON:0004664 ! aorta tunica adventitia property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue def: "A fibroblast that is part of the heart." [GOC:tfm] subset: cellxgene_subset synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002494 {is_inferred="true"} ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002551 name: fibroblast of dermis def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002553 name: fibroblast of lung def: "A fibroblast that is part of lung." [GOC:tfm] subset: cellxgene_subset xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery def: "A fibroblast of pulmonary artery." [GOC:tfm] subset: human_reference_atlas is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002563 name: intestinal epithelial cell def: "An epithelial cell of the intestine." [GOC:tfm] subset: cellxgene_subset is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0001277 ! intestinal epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] subset: cellxgene_subset synonym: "mesenchymal stem cell of adipose" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell def: "A mesenchymal stem cell of liver." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002107 ! liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0002412 ! vertebra relationship: part_of UBERON:0002412 ! vertebra property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002574 name: stromal cell of pancreas def: "A stromal cell of the pancreas." [GOC:tfm] subset: human_reference_atlas is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002585 name: retinal blood vessel endothelial cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 ! brachiocephalic artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery def: "A smooth muscle of the pulmonary artery." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0003336 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0001533 ! subclavian artery relationship: part_of UBERON:0001533 ! subclavian artery property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002610 name: raphe nuclei neuron def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: has_soma_location UBERON:0004684 ! raphe nuclei relationship: has_soma_location UBERON:0004684 ! raphe nuclei property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: has_soma_location UBERON:0002257 ! ventral horn of spinal cord relationship: has_soma_location UBERON:0002257 ! ventral horn of spinal cord property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002620 name: skin fibroblast def: "A fibroblast of skin." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004815 ! lower respiratory tract epithelium relationship: part_of UBERON:0004815 ! lower respiratory tract epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002653 name: squamous endothelial cell def: "A squamous shaped endothelial cell." [GOC:dos] is_a: CL:0000115 ! endothelial cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002657 name: glandular cell of esophagus def: "A glandular epithelial cell of the esophagus." [GOC:tfm] subset: cellxgene_subset xref: FMA:86548 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine def: "A glandular epithelial cell of the large intestine." [GOC:tfm] xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular cell of stomach def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000945 ! stomach property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] synonym: "CPC" RELATED OMO:0003000 [PMID:19745164] is_a: CL:0000048 ! multi fate stem cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002672 name: retinal progenitor cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] is_a: CL:0000048 ! multi fate stem cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002676 name: neural crest derived neuroblast def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from CL:0000333 ! migratory neural crest cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002680 name: PP cell of intestine def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] is_a: CL:0000696 {is_inferred="true"} ! PP cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000160 ! intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: has_soma_location UBERON:0002240 ! spinal cord relationship: has_soma_location UBERON:0002240 ! spinal cord [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS] synonym: "somatic motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron is_a: CL:0000108 ! cholinergic neuron intersection_of: CL:0000100 ! motor neuron intersection_of: synapsed_to CL:0008002 ! skeletal muscle fiber relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of RO:0002577 ! system relationship: synapsed_to CL:0008002 ! skeletal muscle fiber [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] subset: cellxgene_subset is_a: CL:0000048 ! multi fate stem cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string [Term] id: CL:0007001 name: skeletogenic cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000000 ! cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007004 name: premigratory neural crest cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: CL:0011012 ! neural crest cell is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0002342 ! neural crest property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007009 name: prechondroblast def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] subset: cellxgene_subset is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: has_characteristic PATO:0001908 ! multinucleate intersection_of: has_characteristic PATO:0002478 ! transversely striated intersection_of: has_part GO:0030017 ! sarcomere intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: develops_from CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:8600004 ! visceral muscle tissue relationship: part_of UBERON:8600004 ! visceral muscle tissue [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: has_characteristic PATO:0001410 {all_some="true"} ! striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: has_characteristic PATO:0002478 {all_some="true"} ! transversely striated relationship: has_characteristic PATO:0002478 ! transversely striated [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. synonym: "myogenic precursor cell" BROAD [PMID:23303905] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0008002 ! skeletal muscle fiber intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] subset: cellxgene_subset subset: human_reference_atlas synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell relationship: capable_of GO:0016477 ! cell migration relationship: part_of UBERON:0003104 ! mesenchyme property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: part_of UBERON:0002062 ! endocardial cushion relationship: part_of UBERON:0002062 ! endocardial cushion [Term] id: CL:0008024 name: pancreatic endocrine cell def: "An endocrine cell that is part of the pancreas." [GOC:dos] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000163 ! endocrine cell intersection_of: part_of UBERON:0001264 ! pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos] is_a: CL:0000459 ! noradrenergic cell is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission [Term] id: CL:0008028 name: visual system neuron def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of_part_of GO:0007601 ! visual perception relationship: capable_of_part_of GO:0007601 ! visual perception property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2017-07-09T19:12:36Z [Term] id: CL:0008034 name: mural cell def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas is_a: CL:4033054 ! perivascular cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2020-02-29T17:33:55Z [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0010523 ! microcirculatory vessel relationship: part_of UBERON:0010523 ! microcirculatory vessel property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-02-29T17:37:00Z [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] synonym: "spinal sensory neuron" EXACT [] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: has_soma_location UBERON:0001780 ! spinal nerve relationship: has_soma_location UBERON:0001780 ! spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] subset: general_cell_types_upper_slim xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: part_of UBERON:0005388 ! photoreceptor array relationship: part_of UBERON:0005388 ! photoreceptor array [Term] id: CL:0009006 name: enteroendocrine cell of small intestine def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: location_grouping synonym: "small intestine enteroendocrine cell" EXACT [] is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009021 name: stromal cell of lamina propria of large intestine def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine relationship: part_of UBERON:0011189 ! lamina propria of large intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009022 name: stromal cell of lamina propria of small intestine def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: location_grouping is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009024 name: mesothelial cell of small intestine def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping is_a: CL:0000077 ! mesothelial cell is_a: CL:0002254 ! epithelial cell of small intestine is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002108 ! small intestine property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009025 name: mesothelial cell of colon def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] subset: location_grouping synonym: "mesothelial cell of large intestine" BROAD [] is_a: CL:0000077 ! mesothelial cell is_a: CL:0011108 ! colon epithelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001155 ! colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009040 name: stromal cell of lamina propria of colon def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "stromal cell of colon lamina propria" EXACT [] is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0007177 ! lamina propria of mucosa of colon relationship: part_of UBERON:0007177 ! lamina propria of mucosa of colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009042 name: enteroendocrine cell of colon def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: location_grouping synonym: "colon enteroendocrine cell" EXACT [] is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001155 ! colon property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009052 name: smooth muscle cell of anorectum def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "anorectum smooth muscle cell" EXACT [] is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009053 name: stromal cell of anorectum lamina propria def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009063 name: enteroendocrine cell of anorectum def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "anorectum enteroendocrine cell" EXACT [] is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:8410050 ! anorectum relationship: part_of UBERON:8410050 ! anorectum property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009094 name: endothelial cell of hepatic portal vein def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] subset: location_grouping synonym: "portal endothelial cell" BROAD [] xref: EFO:0010704 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001639 ! hepatic portal vein relationship: part_of UBERON:0001639 ! hepatic portal vein property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2021-12-13T14:01:05Z xsd:dateTime [Term] id: CL:0009097 name: embryonic skeletal muscle fiber def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: existence_starts_and_ends_during UBERON:0000068 ! embryo stage relationship: existence_starts_and_ends_during UBERON:0000068 ! embryo stage property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2022-02-21T15:39:10Z xsd:dateTime [Term] id: CL:0009100 name: hepatic portal fibroblast def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] subset: human_reference_atlas synonym: "portal fibroblast" BROAD [] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001279 ! portal triad relationship: part_of UBERON:0001279 ! portal triad property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2825-0621 property_value: http://purl.org/dc/terms/date 2022-03-17T12:00:44Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "A mononuclear cell that is part_of a bone marrow." [] synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0002371 ! bone marrow property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0000948 ! heart [Term] id: CL:0010007 name: His-Purkinje system cell def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0004146 ! His-Purkinje system relationship: part_of UBERON:0004146 ! His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010009 name: camera-type eye photoreceptor cell def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0000966 {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://github.com/obophenotype/cell-ontology/issues/2245"} ! retina [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] xref: MESH:D015053 is_a: CL:0000000 ! cell relationship: seeAlso https://github.com/obophenotype/cell-ontology/issues/786 [Term] id: CL:0010020 name: cardiac glial cell def: "Any glial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0010021 name: cardiac myoblast def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell relationship: develops_into CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] comment: This term is used in 3 GO terms that were created as part of the heart development focus project. subset: cellxgene_subset is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: has_soma_location UBERON:0000948 ! heart relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_soma_location UBERON:0000948 ! heart property_value: seeAlso https://github.com/obophenotype/cell-ontology/pull/1488 xsd:string [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] is_a: CL:0000100 {is_inferred="true"} ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: has_soma_location UBERON:0002240 ! spinal cord relationship: has_soma_location UBERON:0002240 ! spinal cord [Term] id: CL:0011007 name: paraxial cell def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] synonym: "paraxial mesoderm cell" EXACT [] synonym: "presomitic mesoderm cell" NARROW [] synonym: "somitic mesoderm cell" EXACT [] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: part_of UBERON:0003059 ! presomitic mesoderm relationship: part_of UBERON:0003059 ! presomitic mesoderm [Term] id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] subset: cellxgene_subset is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0011019 name: mesothelial cell of epicardium def: "A mesothelial cell that is part of the epicardium." [] subset: cellxgene_subset is_a: CL:0000077 ! mesothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002348 ! epicardium relationship: part_of UBERON:0002348 ! epicardium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011021 name: fibroblast of upper back skin def: "A fibroblast that is part of upper back skin." [] is_a: CL:0011022 ! fibroblast of skin of back intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0009015 ! upper back skin relationship: part_of UBERON:0009015 ! upper back skin property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011022 name: fibroblast of skin of back def: "A fibroblast that is part of skin of back." [] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001068 ! skin of back relationship: part_of UBERON:0001068 ! skin of back property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] subset: cellxgene_subset is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: develops_from CL:0000034 ! stem cell relationship: develops_from CL:0000034 ! stem cell property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011027 name: skeletal muscle fibroblast def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] subset: cellxgene_subset synonym: "skeleton muscle fibroblast" EXACT [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011030 name: dermal microvascular endothelial cell def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] synonym: "dermal microvascular endothelium cell" EXACT [] synonym: "DMEC cell" EXACT [] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] subset: cellxgene_subset synonym: "colonic epithelial cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0000397 ! colonic epithelium [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. subset: cellxgene_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0030154 ! cell differentiation relationship: capable_of GO:0030154 ! cell differentiation [Term] id: CL:0017502 name: acidophilic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: has_characteristic PATO:0002418 ! acidophilic relationship: has_characteristic PATO:0002418 ! acidophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:23:25Z [Term] id: CL:0017503 name: basophilic cytoplasm def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: has_characteristic PATO:0002094 ! basophilic relationship: has_characteristic PATO:0002094 ! basophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:24:54Z [Term] id: CL:0017504 name: polychromatophilic cytoplasm def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: has_characteristic PATO:0070047 ! polychromatophilic relationship: has_characteristic PATO:0070047 ! polychromatophilic property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-28T04:25:23Z [Term] id: CL:0019018 name: blood vessel smooth muscle cell def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] subset: human_reference_atlas synonym: "smooth muscle cell of blood vessel" EXACT [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-07-21T12:42:48Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019020 name: extrahepatic cholangiocyte def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296] is_a: CL:1000488 ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: part_of UBERON:0004822 ! extrahepatic bile duct epithelium relationship: part_of UBERON:0004822 ! extrahepatic bile duct epithelium property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-03T12:24:24Z xsd:dateTime [Term] id: CL:0019021 name: endothelial cell of periportal hepatic sinusoid def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "periportal LSEC" EXACT [PMID:28287163] xref: EFO:0010705 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: adjacent_to UBERON:0001279 ! portal triad relationship: adjacent_to UBERON:0001279 ! portal triad property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-09T13:56:47Z xsd:dateTime [Term] id: CL:0019022 name: endothelial cell of pericentral hepatic sinusoid def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "pericentral LSEC" EXACT [PMID:28287163] xref: EFO:0010706 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: adjacent_to UBERON:0006841 ! central vein of liver relationship: adjacent_to UBERON:0006841 ! central vein of liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/terms/date 2020-09-10T12:38:29Z xsd:dateTime [Term] id: CL:1000222 name: stomach neuroendocrine cell def: "Any neuroendocrine cell that is part of some stomach." [FBC:Autogenerated] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0000945 ! stomach relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) [Term] id: CL:1000223 name: lung neuroendocrine cell def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] subset: cellxgene_subset subset: human_reference_atlas synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253] synonym: "pulmonary neuroendocrine cell" EXACT [PMID:33355253] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0002048 ! lung relationship: capable_of GO:0070483 ! detection of hypoxia relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_part GO:0031045 ! dense core granule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000271 name: lung ciliated cell def: "Any ciliated cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas is_a: CL:4030034 ! respiratory ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000272 name: lung secretory cell def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0000151 ! secretory cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000274 name: trophectodermal cell synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:1000275 name: smooth muscle cell of small intestine def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] subset: cellxgene_subset synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] xref: FMA:15050 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000276 name: smooth muscle fiber of duodenum def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] xref: FMA:15058 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000279 name: smooth muscle cell of large intestine def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] xref: FMA:15653 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000280 name: smooth muscle cell of colon def: "A smooth muscle cell that is part of the colon." [GOC:tfm] synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] xref: FMA:15663 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon [Term] id: CL:1000285 name: smooth muscle cell of sigmoid colon def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] xref: FMA:17521 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon [Term] id: CL:1000286 name: smooth muscle cell of rectum def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] synonym: "smooth muscle fiber of rectum" EXACT [] xref: FMA:17522 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum [Term] id: CL:1000303 name: fibroblast of areolar connective tissue def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] xref: FMA:261279 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0006815 ! areolar connective tissue relationship: part_of UBERON:0006815 ! areolar connective tissue [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] xref: FMA:261285 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002503 ! adventitial cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0007846 ! dense regular connective tissue relationship: part_of UBERON:0002521 ! elastic tissue relationship: part_of UBERON:0007846 ! dense regular connective tissue [Term] id: CL:1000309 name: epicardial adipocyte def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002348 ! epicardium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] subset: cellxgene_subset synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] id: CL:1000361 name: transitional myocyte of interatrial septum def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002085 ! interatrial septum relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263182 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000398 name: endothelial cell of hepatic sinusoid def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] subset: cellxgene_subset subset: human_reference_atlas synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "LSEC" EXACT [PMID:30348985] xref: BTO:000125 xref: FMA:62911 is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002262 ! endothelial cell of sinusoid is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: part_of UBERON:0001281 ! hepatic sinusoid property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000409 name: myocyte of sinoatrial node def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002351 ! sinoatrial node relationship: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0002352 ! atrioventricular node relationship: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000412 name: endothelial cell of arteriole def: "An endothelial cell that is part of the arteriole." [GOC:tfm] subset: human_reference_atlas xref: FMA:67760 xref: KUPO:0001097 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000413 name: endothelial cell of artery def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001917 ! endothelium of artery property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000414 name: endothelial cell of venule def: "An endothelial cell that is part of the venule." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000415 name: epithelial cell of gallbladder def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] xref: FMA:67780 is_a: CL:0000066 ! epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder [Term] id: CL:1000428 name: stem cell of epidermis def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] subset: cellxgene_subset synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000723 ! somatic stem cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis [Term] id: CL:1000443 name: ciliary muscle cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001775 ! ciliary body relationship: part_of UBERON:0001775 ! ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001366 ! parietal peritoneum relationship: part_of UBERON:0001366 ! parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] subset: human_reference_atlas xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0001178 ! visceral peritoneum relationship: part_of UBERON:0001178 ! visceral peritoneum property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: part_of UBERON:0002351 ! sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] xref: FMA:83386 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum [Term] id: CL:1000488 name: cholangiocyte def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] subset: cellxgene_subset synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity intersection_of: part_of UBERON:0002394 ! bile duct relationship: develops_from CL:0005026 ! hepatoblast relationship: part_of UBERON:0002394 ! bile duct [Term] id: CL:1000490 name: mesothelial cell of peritoneum def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002358 ! peritoneum relationship: part_of UBERON:0002358 ! peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura def: "A mesothelial cell that is part of the pleura." [GOC:tfm] subset: cellxgene_subset synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 is_a: CL:0000077 ! mesothelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002400 ! parietal pleura relationship: part_of UBERON:0002400 ! parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0002401 ! visceral pleura property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000083 ! epithelial cell of pancreas intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0000017 ! exocrine pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001516 name: intestinal enteroendocrine cell def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] subset: cellxgene_subset is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0001242 ! intestinal mucosa [Term] id: CL:1001567 name: lung endothelial cell def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0002139 ! endothelial cell of vascular tree is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000102 ! lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0005317 ! pulmonary artery endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001572 name: colon endothelial cell def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] synonym: "colon endothelial cells" RELATED OMO:0003004 [CALOHA:TS-2397] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] xref: CALOHA:TS-2397 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0013695 ! colon endothelium [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: part_of UBERON:0002424 ! oral epithelium [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] xref: CALOHA:TS-1274 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001155 ! colon [Term] id: CL:1001589 name: duodenum glandular cell def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] subset: cellxgene_subset synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0008346 ! duodenal epithelium [Term] id: CL:1001592 name: gallbladder glandular cell def: "Glandular cell of gallbladder epithelium." [NPX:PDR] synonym: "gall bladder glandular cell" EXACT [FMA:7202] synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] xref: CALOHA:TS-1278 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1000415 ! epithelial cell of gallbladder intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002029 ! epithelium of gall bladder [Term] id: CL:1001595 name: rectum glandular cell def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] xref: CALOHA:TS-1281 is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0003354 ! epithelium of rectum [Term] id: CL:1001598 name: small intestine glandular cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR] synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestinal glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286] xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR] subset: human_reference_atlas synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242] synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242] xref: BTO:0000028 xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001630 ! muscle organ relationship: part_of UBERON:0001630 ! muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0012429 ! hematopoietic tissue [Term] id: CL:2000001 name: peripheral blood mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear cell is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000008 name: microvascular endothelial cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium relationship: part_of UBERON:0008339 ! microvascular endothelium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:07:42Z [Term] id: CL:2000010 name: dermis blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:12:06Z [Term] id: CL:2000013 name: fibroblast of skin of abdomen def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: part_of UBERON:0001416 ! skin of abdomen relationship: part_of UBERON:0001416 ! skin of abdomen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:18:16Z [Term] id: CL:2000016 name: lung microvascular endothelial cell def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell intersection_of: part_of UBERON:0008339 ! microvascular endothelium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T16:00:56Z [Term] id: CL:2000019 name: compound eye photoreceptor cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000018 ! compound eye relationship: part_of UBERON:0000018 ! compound eye property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:45Z [Term] id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000087 ! inner cell mass relationship: part_of UBERON:0000087 ! inner cell mass property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:53Z [Term] id: CL:2000022 name: cardiac septum cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] is_a: CL:0002494 ! cardiocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0002099 ! cardiac septum relationship: part_of UBERON:0002099 ! cardiac septum property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000029 name: central nervous system neuron def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: has_soma_location UBERON:0001017 ! central nervous system relationship: has_soma_location UBERON:0001017 ! central nervous system property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T01:17:43Z [Term] id: CL:2000032 name: peripheral nervous system neuron def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas synonym: "peripheral neuron" EXACT [] synonym: "PNS neuron" EXACT [] xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: has_soma_location UBERON:0000010 ! peripheral nervous system relationship: has_soma_location UBERON:0000010 ! peripheral nervous system property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-06-25T02:28:17Z [Term] id: CL:2000042 name: embryonic fibroblast def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:12:00Z [Term] id: CL:2000044 name: brain microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:24:53Z [Term] id: CL:2000046 name: ventricular cardiac muscle cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] subset: cellxgene_subset is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: has_soma_location UBERON:0002298 ! brainstem relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_soma_location UBERON:0002298 ! brainstem property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-02T23:52:53Z [Term] id: CL:2000051 name: splenic fibroblast def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T18:58:47Z [Term] id: CL:2000053 name: splenic endothelial cell def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 subset: human_reference_atlas is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-06T19:06:04Z [Term] id: CL:2000063 name: ovarian fibroblast def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:57:42Z [Term] id: CL:2000064 name: ovarian surface epithelial cell def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 subset: cellxgene_subset is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:59:13Z [Term] id: CL:2000066 name: cardiac ventricle fibroblast def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 subset: human_reference_atlas is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0002082 ! cardiac ventricle property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-07T18:35:38Z [Term] id: CL:2000067 name: cardiac atrium fibroblast def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 subset: human_reference_atlas is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002081 ! cardiac atrium relationship: part_of UBERON:0002081 ! cardiac atrium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 property_value: RO:0002175 NCBITaxon:9606 creation_date: 2014-10-07T18:36:54Z [Term] id: CL:2000068 name: pericardium fibroblast def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002407 ! pericardium relationship: part_of UBERON:0002407 ! pericardium property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:38:06Z [Term] id: CL:2000069 name: gallbladder fibroblast def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 is_a: CL:0000057 ! fibroblast is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0002110 ! gallbladder relationship: part_of UBERON:0002110 ! gallbladder property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:41:43Z [Term] id: CL:2000070 name: optic choroid fibroblast def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 is_a: CL:0000057 ! fibroblast is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001776 ! optic choroid relationship: part_of UBERON:0001776 ! optic choroid property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:50:43Z [Term] id: CL:2000072 name: adipose microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: part_of UBERON:0001013 ! adipose tissue property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T22:13:45Z [Term] id: CL:2000073 name: migratory cardiac neural crest cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] synonym: "cardiac neural crest cell" EXACT [PMID:33060096] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: part_of UBERON:0000095 ! cardiac neural crest relationship: part_of UBERON:0000095 ! cardiac neural crest property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:18:43Z [Term] id: CL:2000074 name: splenocyte def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. is_a: CL:0000738 ! leukocyte is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: CL:0000738 ! leukocyte intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:26:50Z [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] synonym: "mesenchymal stem cell of abdominal adipose" EXACT [] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0000916 ! abdomen property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:10:34Z [Term] id: CL:3000000 name: ciliated epithelial cell of esophagus def: "A ciliated epithelial cell of the esophagus." [GOC:CellBLAST, PMID:29802404] is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000067 ! ciliated epithelial cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus relationship: part_of UBERON:0001976 ! epithelium of esophagus property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-09T16:40:30Z [Term] id: CL:3000004 name: peripheral sensory neuron def: "Peripheral sensory neuron." [GOC:CellBLAST, PMID:30096314] is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception property_value: http://purl.org/dc/terms/contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-25T19:34:33Z [Term] id: CL:4023072 name: brain vascular cell def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas is_a: CL:0002319 ! neural cell is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0008998 ! vasculature of brain relationship: part_of UBERON:0008998 ! vasculature of brain property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas is_a: CL:0000540 ! neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: develops_from UBERON:0001891 ! midbrain relationship: develops_from UBERON:0001891 ! midbrain property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023168 name: somatosensory neuron def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0003942 ! somatosensory system relationship: part_of UBERON:0003942 ! somatosensory system property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4028001 name: pulmonary capillary endothelial cell def: "Any capillary endothelial cell that is part of a lung." [] synonym: "lung capillary endothelial cell" EXACT [] is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000016 ! lung microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0016405 ! pulmonary capillary property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T02:31:40Z [Term] id: CL:4030034 name: respiratory ciliated cell def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." [PMID:18757316, PMID:21364219] synonym: "ciliated cell of the respiratory tract" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium relationship: part_of UBERON:0004802 ! respiratory tract epithelium property_value: http://purl.org/dc/terms/date 2023-01-25T11:06:01Z xsd:dateTime [Term] id: CL:4033008 name: vein endothelial cell of respiratory system def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] subset: human_reference_atlas is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033018 name: lung megakaryocyte def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] subset: human_reference_atlas synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116] synonym: "lung resident megakaryocyte" EXACT [PMID:36524131] synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131] synonym: "MKL" RELATED OMO:0003000 [PMID:36524131] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000556 ! megakaryocyte intersection_of: part_of UBERON:0000114 ! lung connective tissue relationship: part_of UBERON:0000114 ! lung connective tissue property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-9185-3994 property_value: http://purl.org/dc/terms/date 2023-03-16T11:31:23Z xsd:dateTime property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033050 name: catecholaminergic neuron def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209] comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0160043 ! catecholamine secretion, neurotransmission relationship: capable_of GO:0160043 ! catecholamine secretion, neurotransmission property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/date 2023-05-18T12:07:45Z xsd:dateTime [Term] id: CL:4033054 name: perivascular cell def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: adjacent_to UBERON:0002049 ! vasculature relationship: adjacent_to UBERON:0002049 ! vasculature property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 property_value: http://purl.org/dc/terms/date 2023-08-22T13:40:28Z xsd:dateTime [Term] id: CL:4033061 name: endothelial cell of central vein of liver def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163] synonym: "endothelial cell of central vein" BROAD [PMID:28287163] is_a: CL:0002543 ! vein endothelial cell is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0006841 ! central vein of liver relationship: part_of UBERON:0006841 ! central vein of liver property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] synonym: "OAMSC" EXACT [PMID:31377878] synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878] synonym: "Orbital ASCs" EXACT [PMID:30210548] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: part_of UBERON:0004088 ! orbital region relationship: part_of UBERON:0004088 ! orbital region property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-0819-0473 property_value: http://purl.org/dc/terms/date 2023-09-18T10:43:00Z xsd:dateTime [Term] id: ECAO:00000000 name: root node [Term] id: ECAO:0000010 name: life cycle period [Term] id: ECAO:0000020 name: gametogenesis def: "Biological process during which certain cells of a female or male individual (parent) are transformed into specialized reproductive cells (gametes) that will initiate development of a progeny individual (offspring) upon fertilization." [] is_a: UBERON:0000105 ! life cycle stage relationship: part_of ECAO:0000010 ! life cycle period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000030 name: oogenesis period def: "Period during which female gametes (or oocytes, or eggs) develop and mature from primordial female germ cells to generate cells competent to further development upon fertilization by a mature spermatozoid." [] synonym: "ovogenesis period" EXACT [] relationship: part_of ECAO:0000020 ! gametogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000040 name: previtellogenic primary oocyte stage def: "A female gamete that is small in size, i.e. about 10 microm in diameter, and that is at the previtellogenic stage." [] relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000050 name: not fully grown oocyte stage def: "A developing female gamete that started growing in size by accumulation of yolk proteins. At this stage, it is characterized by the presence of a large nucleus, the germinal vesicle, which contains a prominent nucleolus and occupies most of the cytoplasm." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000060 name: fully grown oocyte with centered germinal vesicle stage def: "A developing female gamete that has reached its full size. It has grown up to ten times its original size, i.e. 80 to 100microm. It also displays a large germinal vesicle that is centered, but it is still not competent for fertilization." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000050 ! not fully grown oocyte stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000070 name: fully grown oocyte with off-centered germinal vesicle stage def: "A developing female gamete that has reached its full size and in which the germinal vesicle has moved asymmetrically to the cell periphery. The germinal vesicle is now close to the animal pole." [] synonym: "primary oocyte" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000060 ! fully grown oocyte with centered germinal vesicle stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000080 name: fully grown oocyte with no nucleus stage def: "A developing female gamete in which the germinal vesicle has broken down. The germinal vesicle is no longer visible. However, the female gamete is still not mature. It is undergoing meiotic maturation, extruding successively a first and a second polar body." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000070 ! fully grown oocyte with off-centered germinal vesicle stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000090 name: mature oocyte stage def: "A mature female gamete that has achieved its meiotic maturation and in which the female pronucleus is visible. The mature oocyte is arrested in G1 phase and its average size is 80 to 100 µm. It is surrounded by a transparent jelly coat that is about 30 µm thick. It is competent to fertilization and it is located in the female gonad where it may be stored for weeks to months before its release in sea water by spawning. In the P. lividus species, the mature female gametes are characterized by the presence of pigment granules concentrated in a subequatorial band. This band is classically called the pigment band and allows to visualize the first embryonic axis, i.e. the animal-vegetal axis, which is perpendicular to the band." [] synonym: " spawned egg" EXACT [] synonym: "unfertilized egg" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000080 ! fully grown oocyte with no nucleus stage relationship: part_of ECAO:0000030 ! oogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000100 name: spermatogenesis period def: "Period during which male gametes (or spermatozoa, or spermatozoid) develop and mature from primordial male germ cells to generate cells competent to further development upon fertilization of a mature oocyte." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000030 ! oogenesis period relationship: part_of ECAO:0000020 ! gametogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000110 name: developing spermatozoa stage def: "A developing, immature male gamete undergoing mitosis and meiosis to ultimately produce mature spermatozoa." [] synonym: "spermatid" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000090 ! mature oocyte stage relationship: part_of ECAO:0000100 ! spermatogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000120 name: mature spermatozoid stage def: "A mature male gamete that is composed of a head, encompassing a compact nucleus, a neck, a middle piece, and a tail (or flagellum) that propels it towards the oocyte upon spawning." [] synonym: " spermatozoa" EXACT [] synonym: "sperm" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000110 ! developing spermatozoa stage relationship: part_of ECAO:0000100 ! spermatogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000130 name: embryogenesis def: "Biological process during which the embryo forms. This process starts with the fertilization of a mature oocyte by a mature spermatozoid. It is characterized by a succession of rapid mitotic divisions with no significant growth, but with axis establishment and cellular differentiation, thereby leading to the development of a multicellular embryo." [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ECAO:0000020 ! gametogenesis relationship: part_of ECAO:0000010 ! life cycle period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000135 name: stage 1 def: "Fertilization has occurred but the zygote has not divided (1-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000100 ! spermatogenesis period relationship: part_of ECAO:0000130 ! embryogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000140 name: 1-cell stage def: "A fertilized egg, right after fertilization. The embryo is characterized morphologically by the fact that it is a single diploid cell surrounded by a fertilization envelope. This stage corresponds to an embryo of age 0 hour post-fertilization." [] synonym: " fertilized egg" EXACT [] synonym: "zygote stage" EXACT [] xref: UBERON:0000106 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000100 ! spermatogenesis period relationship: part_of ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000150 name: cleavage period def: "Period during which the fertilized egg undergoes a succession of rapid cell divisions with no significant growth." [] xref: UBERON:0000107 is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000130 ! embryogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000155 name: stage 2 def: "The embryo is composed of 2 cells (2-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000135 ! stage 1 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000160 name: 2-cell stage def: "An embryo that is composed of two cells and is surrounded by a fertilization envelope. The first cleavage plane took place meridionally (i.e. along the animal-vegetal axis), thereby generating two blastomeres of equal size, each containing both animal and vegetal cytoplasm." [] synonym: "2c" EXACT [] xref: UBERON:0007232 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000140 ! 1-cell stage relationship: part_of ECAO:0000155 ! stage 2 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000165 name: stage 3 def: "The embryo is composed of 4 cells (4-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000155 ! stage 2 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000170 name: 4-cell stage def: "An embryo that is composed of four cells and is surrounded by a fertilization envelope. The second cleavage plane was meridional and perpendicular to the first one, thereby producing four blastomeres of equal size, each containing both animal and vegetal cytoplasm." [] synonym: "4c" EXACT [] xref: UBERON:0007233 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000160 ! 2-cell stage relationship: part_of ECAO:0000165 ! stage 3 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000175 name: stage 4 def: "The embryo is composed of 8 cells (8-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000165 ! stage 3 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000180 name: 8-cell stage def: "An embryo that is composed of eight cells and is surrounded by a fertilization envelope. The third cleavage took place perpendicular to the first two cleavage planes and was equatorial. It thus generated an animal and a vegetal hemisphere each composed of a quartet of four cells of equal volume." [] synonym: "8c" EXACT [] xref: UBERON:0007236 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000170 ! 4-cell stage relationship: part_of ECAO:0000175 ! stage 4 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000185 name: stage 5 def: "The embryo is composed of 16 cells (16-cell stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000175 ! stage 4 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000190 name: 16-cell stage def: "An embryo that is composed of 16 cells and is surrounded by a fertilization envelope. Note for euechinoid indirect developers: although the fourth cleavage occurred simultaneously in all cells, the pattern of cell division differed in the animal and vegetal blastomeres. In the animal hemisphere the four cells divided meridionally, producing eight blastomeres of equal volume arrayed in a single tier. These cells are called the mesomeres. In the vegetal hemisphere, the four cells underwent an unequal, equatorial cleavage, producing a tier of four large cells, the macromeres, and a tier of four small cells, the micromeres, located at the vegetal pole. At the 16-cell stage, the embryo is hence composed of three groups of cells with distinct sizes. In most sea urchin species,this is the first morphological indication of the animal-vegetal axis." [] synonym: "16c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000180 ! 8-cell stage relationship: part_of ECAO:0000185 ! stage 5 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000195 name: stage 6 def: "The embryo is composed of 28-32 cells (includes 28- and 32-cell stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000185 ! stage 5 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000200 name: 28-cell stage def: "An embryo that is composed of 28 cells and is surrounded by a fertilization envelope. Note for euechinoid indirect developers: In most sea urchin species, the fifth cleavage signed the end of cell division synchrony, with the mesomeres and macromeres dividing prior to the micromeres with a significant time difference. In the animal hemisphere, the mesomeres underwent an equal and equatorial cleavage, giving rise to two animal cell tiers, each composed of eight blastomeres of equal size: the an1 tier located at the animal pole and the an2 tier located below an1. In parallel, the macromeres divided meridionally, forming a ring of eight cells of equal volume located below the an2 tier. At that stage, the micromeres have not yet divided and are still at a number of four cells." [] synonym: "28c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000190 ! 16-cell stage relationship: part_of ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000210 name: 32-cell stage def: "An embryo that is composed of 32 cells and is surrounded by a fertilization envelope. Note for euechinoid indirect developers: The micromeres have undergone a fifth cleavage (and this has occurred prior to a subsequent division of the other cells). This cleavage was unequal and equatorial, thereby producing four large micromeres and four small micromeres, the smallest cells still marking the vegetal pole." [] synonym: "32c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000200 ! 28-cell stage relationship: part_of ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000215 name: stage 7 def: "The embryo is composed of 56-64 cells (includes 56-, 60-, and 64-cell stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000195 ! stage 6 relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000220 name: 56-cell stage def: "An embryo that is composed of 56 cells and is surrounded by a fertilization envelope. Note for euechinoid indirect developers: In the animal hemisphere, cells of the an1 and an2 tiers underwent an additional meridional division, producing tiers composed of 16 cells. The macromeres divided equatorially and equally, generating two vegetal cell tiers, each composed of 8 cells of equal volume, namely the veg1 tier (located below an2) and the veg2 tier (located below veg1 and above the large micromeres). At that stage, the large and small micromeres (4 cells each) have not undergone yet a sixth division." [] synonym: "56c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000230 name: 60-cell stage def: "An embryo that is composed of 60 cells and is surrounded by a fertilization envelope. Note for euechinoid indirect developers: The large micromeres have achieved a sixth cleavage, which was meridional, thereby generating a ring of 8 cells. At that stage, from the animal to the vegetal pole, the embryo is composed of: 16 an1-cells, 16 an2-cells, 8 veg1-cells, 8 veg2-cells, 8 large micromeres and 4 small micromeres." [] synonym: "60c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000220 ! 56-cell stage relationship: part_of ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000235 name: 64-cell stage def: "64-cell stage" [] synonym: "64c" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0000150 ! cleavage period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000240 name: blastula period def: "Period during which the embryo is transformed into a hollow sphere that is one cell layer thick and encompasses a central, fluid-filled cavity called the blastocoel. During this period, every cell of the embryo is in contact on the inside with the blastocoel and on the outside with the hyaline layer." [] xref: UBERON:0000307 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000150 ! cleavage period relationship: part_of ECAO:0000130 ! embryogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000250 name: very early blastula stage def: "The embryo is composed of 110-120 cells, as most blastomeres have completed an additional mitotic division after the 60-cell stage. The embryo is surrounded by a fertilization envelope. All cells are about the same size and there are no obvious morphological indications of embryonic polarity or embryonic territories. All cells have begun to acquire apico-basal polarity, and the embryo is beginning to transform into a hollow sphere with a wall that is one cell layer thick and a fluid-filled cavity (the blastocoel) in the center. Note for euechinoid indirect developers: the micromere progeny divide more slowly than other cells of the embryo. Molecular labelling typically indicates the presence of 8 large micromere descendants and 4 small micromeres at this stage ." [] synonym: " 120-cell stage" EXACT [] synonym: " B1" EXACT [] synonym: "vEB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000230 ! 60-cell stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000255 name: stage 8 def: "The embryo is an early blastula (early blastula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000215 ! stage 7 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000260 name: early blastula stage def: "The embryo is composed of slightly more than 200 cells, as most blastomeres have completed an additional mitotic division after the very early blastula stage. The embryo is surrounded by a fertilization envelope. The embryo remains spherical and one cell layer thick, and the blastocoel has expanded slightly since the very early blastula stage, without increasing though the size of the embryo. The synchrony of cell divisions between animal and vegetal cell tiers, as well as within cell tiers, is becoming less pronounced. Note for euechinoid indirect developers: Molecular labeling typically indicates the presence of 16 large micromere descendants and 4 small micromeres at this stage ." [] synonym: " B2" EXACT [] synonym: "EB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000250 ! very early blastula stage relationship: part_of ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000265 name: stage 9 def: "The embryo is a mid-blastula (includes mid-blastula and motile blastula stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000255 ! stage 8 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000270 name: mid-blastula stage def: "The embryo is composed of about 300 cells and is surrounded by a fertilization envelope. Cell divisions are less synchronous than at earlier stages. The cells have flattened slightly on their inner (basal) surface, further contributing to the enlargement of the blastocoel. In some species, cells have started to form cilia on their outer surface. The embryo is still spherical and does not display any obvious morphological landmarks that indicate the primary or secondary embryonic axes. Note for euechinoid indirect developers: molecular labeling typically indicates the presence of 16 to 32 large micromere descendant cells and 4 to 8 small micromere descendants at this stage ." [] synonym: " B3" EXACT [] synonym: " midB" EXACT [] synonym: "mid-B" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000260 ! early blastula stage relationship: part_of ECAO:0000265 ! stage 9 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000275 name: stage 10 def: "The embryo is a late blastula, it is still spherical, and the vegetal plate has not formed (late blastula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000265 ! stage 9 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000280 name: late blastula stage def: "The embryo is composed of about 400 cells and is surrounded by a fertilization envelope. The embryo is still spherical but the wall is thinner and smoother than at previous stages. The vegetal plate has not formed. Many cells are ciliated, and in some species (e.g. P. lividus) the embryo has begun to rotate within the fertilization envelope, while in others (e.g. S. purpuratus) it is still non-motile. Note for euechinoid indirect developers: molecular labeling typically indicates the presence of 32 large micromere descendants and 4 to 8 small micromere descendants at this stage ." [] synonym: " B4" EXACT [] synonym: " LB" EXACT [] synonym: " pre-HB" EXACT [] synonym: " prehatched blastula" EXACT [] synonym: "Late-B" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000270 ! mid-blastula stage relationship: part_of ECAO:0000275 ! stage 10 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000284 name: stage 11 def: "The embryo, whether or not hatched from the fertilization envelope, has formed a vegetal plate but gastrulation has not begun (vegetal plate stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000275 ! stage 10 relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000286 name: stage 12 def: "The embryo has hatched from the fertilization envelope and is undergoing the earliest cell movements of gastrulation (includes early, mid-, and late mesenchyme blastula stages and blastopore formation stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000284 ! stage 11 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000290 name: hatched blastula stage def: "The embryo is composed of about 800 cells and is surrounded by a fertilization envelope. The fertilization envelope has started to break down due to the secretion by ectodermal cells of the hatching enzyme, a metalloprotease that digests the fertilization envelope and frees the embryo. The vegetal plate has not formed. The embryo rotates within the envelope or swims away as soon as it is free. At the animal pole, a tuft of long and immotile cilia has started growing." [] synonym: " B5" EXACT [] synonym: " very late blastula stage" EXACT [] synonym: "HB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000300 name: swimming blastula stage def: "The embryo has hatched from the fertilization envelope and swims freely. It is still a hollow sphere that is one cell layer thick, but the cells constituting the vegetal plate (i.e. located at the vegetal pole) have started thickening along the apico-basal axis, thereby creating a morphological landmark that enables orienting the embryo along the animal-vegetal axis. In addition, at the animal pole, the apical tuft composed of long and immotile cilia has continued expending." [] synonym: "SB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000290 ! hatched blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000310 name: late swimming blastula stage def: "The embryo has started elongated along the animal-vegetal axis. Its vegetal region has further continued to thicken and it is marked by a characteristic 'V' shape formed by the blastocoel at the level of the cells constituting the vegetal plate, thereby pointing to the vegetal pole. At the animal pole, the embryo is characterized by the presence of an apical tuft." [] synonym: "late-SB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000300 ! swimming blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000320 name: gastrula period def: "Period during which complex and coordinated cellular movements take place and ultimately generate a three-layered embryo with inner tissues. A portion of cells will ingress, invaginate and/or migrate within the embryo and form the two inner layers (i.e. the endoderm and the mesoderm). The cells that remained outside will instead spread over the whole surface of the embryo and form the outer layer (i.e. the ectoderm)." [] xref: UBERON:0000109 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000240 ! blastula period relationship: part_of ECAO:0000130 ! embryogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000330 name: mesenchyme blastula phase def: "The phase during which skeletogenic primary mesenchyme cells (PMCs) move from the vegetal plate into the blastocoel (ingress) but before the vegetal plate has started to invaginate." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000340 name: early mesenchyme blastula stage def: "The vegetal plate is apparent and skeletogenic primary mesenchyme cells (PMCs) are in the process of ingression, a type of epithelial–mesenchymal transition (EMT). The epithelial wall of the embryo has thickened at the animal pole, where a tuft of long, non-motile cilia has formed." [] synonym: "eMB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000350 name: mid-mesenchyme blastula stage def: "All skeletogenic primary mesenchyme cells (PMCs) have ingressed into the blastocoel, leaving behind a reformed vegetal plate containing at its center the 8 small micromere descendants surrounded by non-skeletogenic mesoderm cells. The PMCs are organized in a mound on the vegetal plate but have not begun to disperse. The thickened apical pole domain with its tuft of long, non-motile cilia is still apparent." [] synonym: "mid-MB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000340 ! early mesenchyme blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000360 name: late mesenchyme blastula stage def: "The skeletogenic primary mesenchyme cells (PMCs) have migrated away from the vegetal plate by extending filopodia and moving along the blastocoel wall. The vegetal plate has flattened but has not started to invaginate. The apical pole domain still bears an apical tuft of long, non-motile cilia." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000350 ! mid-mesenchyme blastula stage relationship: part_of ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000370 name: invagination phase def: "Period during which the inpocketing and elongation of the archenteron takes place." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000380 name: blastopore formation stage def: "The embryo is characterized morphologically by a slight invagination of the vegetal plate and the dispersal of the skeletogenic primary mesenchyme cells (PMCs) along the blastocoel wall at the periphery of the invaginating region. The PMCs are just beginning to adopt a characteristic, ring-like arrangement near the equator of the embryo. Within the vegetal plate, the peripheral non-skeletogenic mesoderm cells have started to indent, undergoing important cell shape changes, but the center of the vegetal plate (composed of small micromeres) has not started to elevate. Invagination has generated the blastopore (an opening that will give rise to the larval anus) as well as the anterior portion of the archenteron (a region that will give rise to the coelomic pouches). At the animal pole, the apical pole domain is still marked by an enlarged epithelium bearing long and immotile cilia." [] synonym: " blastopore gastrula stage" EXACT [] synonym: "blasto-G" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000360 ! late mesenchyme blastula stage relationship: part_of ECAO:0000370 ! invagination phase property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000385 name: stage 13 def: "The embryo is undergoing the first phase of archenteron extension (early gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000286 ! stage 12 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000390 name: early gastrula stage def: "The embryo is mainly characterized morphologically by the presence in the blastocoel of a small archenteron (i.e. primitive digestive tract) that is about a third of its finally size. Following the initial invagination of the vegetal plate, the archenteron has slightly been extended, within the blastocoel, by the subsequent invagination of additional non-skeletogenic mesoderm cells and of some endoderm cells. In parallel, the skeletogenic mesenchyme cells (or SM cells, primary mesenchyme cells or PMC) have by now started migrating along the blastocoel wall, towards the animal pole, thereby creating two lateral chains (one left and one right), while around the developing archenteron, they have gathered into two ventrolateral clusters separated by an oral (or ventral) and an aboral (or dorsal) chain defined by the remaining skeletogenic mesenchyme cells. Within the oral and aboral skeletogenic mesenchyme chains, the cells have further started to fuse to form syncytial filopodial cables within which skeletal calcification will subsequently take place. At the animal pole, the animal neuroectoderm territory is still marked by an enlarged epithelium bearing long and immotile cilia." [] synonym: " EG" EXACT [] synonym: "eG" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000380 ! blastopore formation stage relationship: part_of ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000395 name: stage 14 def: "The embryo is undergoing the middle phase of archenteron extension (mid-gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000385 ! stage 13 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000400 name: mid-gastrula stage def: "The embryo is mainly characterized morphologically by the presence of an archenteron (i.e. primitive digestive tract) that has reached one-half its way into the blastocoel. A second phase of archenteron elongation has taken place by invagination of additional cells into the blastocoel, by cell division or by convergent-extension movements depending on the sea urchin species. Non-skeletogenic mesoderm cells that are present at the tip of the archenteron have further started ingressing into the blastocoel, generating the non-skeletogenic mesenchyme cells (or NSM cells, secondary mesenchyme cells or SMC). The oral ectoderm has also started to flatten and to become thicker, providing the first morphological indicator of the oral-aboral (or ventro-dorsal) axis of the embryo. As a consequence the oral chain formed by a portion of the skeletogenic mesenchyme cells has also flattened. Finally, skeletal calcification has further begun within the skeletogenic mesenchyme ventrolateral clusters, marked by the presence of the first calcified structures, which appear as small dots at that stage. At the animal pole, the animal neuroectoderm territory is still marked by an enlarged epithelium bearing long and immotile cilia." [] synonym: " mid-G" EXACT [] synonym: "G" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0000395 ! stage 14 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000405 name: stage 15 def: "The embryo is undergoing the last phase of archenteron extension (late gastrula stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000395 ! stage 14 relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000410 name: late gastrula stage def: "The embryo is mainly characterized morphologically by the presence in the blastocoel of a fully extended archenteron (i.e. primitive digestive tract) that has now reached the roof of the blastocoel. The third and last extension phase of the archenteron has been ensured by pulling forces exerted by non-skeletogenic mesoderm cells that are still present at the tip of the archenteron. These cells have produced filopodia that extended towards the animal pole, attached the wall, and then shortened, thereby pulling up the archenteron. In some sea urchin species, this pulling force is already orienting the tip of the archenteron towards the oral ectoderm, where the future mouth of the larvae will form. In parallel, in the blastocoel, additional non-skeletogenic mesoderm cells continued ingressing from the tip of the archenteron and the skeletal calcified structures present in the skeletogenic mesenchyme ventrolateral clusters have further grown, forming now the primary triradiate skeletal rudiments (or spicules). At the animal pole, the animal neuroectoderm territory is still marked by an enlarged epithelium bearing long and immotile cilia." [] synonym: " late-G" EXACT [] synonym: "LG" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000420 name: organogenesis period def: "To be written" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000320 ! gastrula period relationship: part_of ECAO:0000130 ! embryogenesis property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000422 name: stage 16 def: "The embryo has completed archenteron elongation and mesenchyme cell ingression is complete (includes early prism and early organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000405 ! stage 15 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000424 name: stage 17 def: "The embryo has paired coelomic evaginations at the tip of the archenteron but lacks a stomodeal invagination and gut constrictions (includes late prism and mid-organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000422 ! stage 16 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000426 name: stage 18 def: "The embryo has paired coelomic pouches along with a stomodeal invagination and gut constrictions (includes late and very late organogenesis stages)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000424 ! stage 17 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000428 name: stage 19 def: "The embryo has an open mouth (open mouth stage)." [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000426 ! stage 18 relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000430 name: prism stage def: "The embryo is mainly characterized morphologically by a typical triangular shape, the beginning of the tripatition of the digestive tract and the presence of pigmented cells. The oral (or ventral) ectoderm has by now even more flattened, making an almost perfect right angle with the blastoporal side of the embryo. By contrast, on the opposite side, the aboral (or dorsal) ectoderm has round up and slightly elongated, thereby forming the primitive apex of the future larvae. These changes have conferred the embryo a typical and easy recognizable triangular shape. In the oral ectoderm, a small depression has further appeared, called the stomodeum, which will later fuse with the tip of the archenteron to form the mouth. In the blastocoel, the digestive tract has also by now bended toward the stomodeum and started to become tripartite. The cardiac sphincter has started forming, separating the future esophagus from the future stomach. The triradiate spicules have also continued elongating, thereby forming by now, towards the animal pole, the right and left dorsoventral connecting rods, towards the apex, the body rods, and along the vegetal, oral ectoderm the left and right ventral transverse rods. Moreover, some non-skeletogenic mesenchyme cells (or NSM cells, secondary mesenchyme cells or SMC) have started becoming pigmented and inserted into the aboral ectoderm. These cells represent part of the future immune system of the larvae along with other blastocoelar cells that are present in the blastocoel around the gut. In the vicinity of the future esophagus, other non-skeletogenic mesoderm descendant cells along with some endoderm cells have further arranged to form a single unpaired coelomic pouch. At the animal pole, the apical pole domain has also started to flatten making the embryo look like a square when viewed from the oral side, and it still arbors a tuft a long and immotile cilia. Finally, within the apical pole domain, but not yet in the ciliary band, molecular labeling surveys also start by this stage to reveal the presence of differentiating neuronal cells." [] synonym: " D" EXACT [] synonym: "Pr" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000370 ! invagination phase relationship: part_of ECAO:0000420 ! organogenesis period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000440 name: larval development is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000130 ! embryogenesis relationship: part_of ECAO:0000010 ! life cycle period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000450 name: early feeding larva period def: "Biological process during which the specific outcome is the progression of a free-living larva before the development of the adult. Indirect development represents the mainstream developmental mode of metazoans. This process usually starts with the emergence of a larva that is planktonic and stops at the end of metamorphosis once the animal assumes adult characters." [] xref: UBERON:0000069 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ECAO:0000420 ! organogenesis period relationship: part_of ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000460 name: early pluteus larva stage def: "The embryo is by now a fully formed pluteus larva. The mouth has opened and the digestive tract is becoming functional. On the ventral side, the mouth is surrounded anteriorly by an oral hood and posteriorly by two postoral arms. On the dorsal side, the apex has lengthened. The skeleton has indeed continued extending, expending the dorsoventral connecting rods, the body rods, and the ventral transverse rods as well as developing the anterolateral rods and the postoral rods. Within the larva, the tripartition of the digestive tract has further progressed. The cardiac sphincter is now fully formed in between the esophagus and the stomach, and the pyloric sphincter in between the stomach and the intestine and the anal sphincter at the level of the anus have also started forming. Around the esophagus, the coelomic pouch has further developed into two bilobed sacs (or pouches), one on each side of the digestive tract. Finally, within the apical pole domain, as well as within the ciliary band, differentiated neurons with their extended axons can also now be distinguished by immunostaining. In parallel, the apical tuft of long and immotile cilia remains discernable at the tip of the oral hood, while in parallel the ciliary band has further started growing a concentrated number of intermediate size motile cilia, which will be used by the larva to swim directionally." [] synonym: " 2-arm pluteus stage" EXACT [] synonym: " early pluteus stage" EXACT [] synonym: "Eplut" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000430 ! prism stage relationship: part_of ECAO:0000450 ! early feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000470 name: 4-arm pluteus larva stage def: "The 4-arm pluteus larva is mainly characterized morphologically by the presence, on the ventral side, of four extended arms (two anterolateral arms at the level of the oral hood and two postoral arms) and on the dorsal side by a sleeked apex. The larva now possesses a completely tripartite and functional digestive tract composed of an esophagus, a stomach, and an intestine, respectively limited by a cardiac sphincter, a pyloric sphincter, and an anal sphincter. Around the esophagus, the right and left coelomic pouches have further started to grow in size and elongate. The first morphological indicator of a left-right asymmetry becomes apparent at that stage, the left coelomic pouch being slightly more elongated than the right one. Furthermore, a thin protrusion of non-skeletogenic mesenchyme cells can be seen extending from the left coelomic pouch to the anterior ectoderm. This is the primary pore canal, which opens to the exterior environment by the hydropore. The larva further now possesses, all around the esophagus, a network of contractile muscles allowing it to swallow and feed. Finally, the apical tuft previously observed at the animal pole has by now disappeared, leaving behind only the concentrated stretch of intermediate size cilia borne by the ciliary band." [] synonym: " P" EXACT [] synonym: " Plut" EXACT [] synonym: " Plut4a" EXACT [] synonym: " pluteus larva" EXACT [] synonym: "Pluteus" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0000450 ! early feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000480 name: late feeding larva period def: "To be written" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000450 ! early feeding larva period relationship: part_of ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000490 name: 6-arm pluteus larva stage def: "The 6-arm pluteus larva is mainly characterized morphologically by the presence, on the ventral side, of six arms, and by the development, on the anterior midline of the esophagus, of the dorsal arch. The larva has indeed extended on the ventral side two additional posterodorsal arms and has developed on the anterior side an additional skeletal element called the dorsal arch. In addition, at the basis of the postoral and posterodorsal arms, four small patches of ciliary band have by now cut off and migrated toward the apex, forming four patches of ciliated structures called the epaulettes (one posterior and one anterior pair). The nervous system of the larva has also become more complex with cell bodies and axons being present all along the arms and for the latter as well throughout the apex. The left and right coelomic pouches have continued to elongate on each side of the digestive tract. As a note this stage is relatively fleeting." [] synonym: "Plut6a" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0000480 ! late feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000500 name: 8-arm pluteus larva stage def: "The 8-arm pluteus larva is mainly characterized morphologically by the presence on the ventral side of the larva of eight arms and by the development within the larva, on the left side of the stomach, of the adult rudiment. This stage is relatively long. It includes distinct changes occurring to the larva as well as within the larva, although the larva consistently exhibits 8 arms. In addition, it should be highlighted that the sequence of events taking place at the level of the larva compared to that occurring on the left side of the stomach to form the rudiment are heterochronic, meaning that differences are observed among individuals in the relative timing of these events. From the larval point of view, at that stage, on the anterior side, the dorsal arch has extended out of the oral hood, thereby forming two additional arms above the mouth, i.e. the preoral arms. In parallel, across the apex, the epaulettes have continued developing, thereby generating four large structures rich in cilia and perpendicular to the ventro-dorsal axis. At the tip of the apex, the suture of the body rods has also eventually ruptured, considerably enlarging the larval apex and reducing the angle between the postoral and posterodorsal arms. In parallel, inside the larva, the left coelomic pouch has also by now been partitioned into three parts: the axocoel (upper part, close to the esophagus), the hydrocoel (middle part) and the somatocoel (lower part, next to the stomach). Likewise, on the opposite side, the right coelomic pouch has also been partitioned into a right axohydrocoel and a right somatocoel, although the right axohydrocoel remains in a rudimentary state compared to its left counterparts. In addition, at the basis of the posterodorsal arm on the left side, a small portion of the ectoderm has thickened, invaginated, and came into contact with the left hydocoel. This structure is called the vestibule and together with the left hydrocoel and the left stomatocoel they have further subsequently fused to form the adult rudiment. The formation of the rudiment has overall taken some time, giving rise first to a pentaradial disc and then to a pentaradial complex structure harboring podia (i.e. tube feet) and spines. In parallel, on the right size of the larva, a variable number of pedicellariae (one to four) and endoskeletal elements (i.e. the five genital plates) have further formed, which will also later contribute to the composition of the adult body." [] synonym: "Plut8a" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0000480 ! late feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000510 name: competent pluteus larva stage def: "The competent pluteus larva is mainly characterized morphologically by the presence, on the ventral size, of still 8 arms and by the presence on the left side of the stomach of the rudiment that is now the size of or even bigger than the stomach. The rudiment further harbors by now five long primary podia (i.e. tube feet), five quartets of definitive spines located between the primary podia and five pairs of immature spines at the basis of the primary podia, while on the opposite side, i.e. on the right side of the larva, five to seven immature spines have further developed, supported by the genital plates, along with one to four pedicaellariae. At the level of the larva, in parallel, the anterior and posterior pairs of epaulettes have also considerably increased in size by now and even fused dorsally to the hydropore and to the anus respectively, thereby leaving exempt of cilia two lateral fields in between them. At the center of the left lateral field, the vestibular roof has also by now ruptured and this opening has created the vestibular pore, through which some primary podia of the rudiment protrude outside the larva and scrutinize the substrate looking for the adequate cues to begin metamorphosis. At that stage, the larva is thus exhibiting a typical substrate-test behavior, going to the sea bottom and scrutinizing the substrate. This behavior is characteristic of a larva named competent to metamorphosis, which it will accomplish providing that it is adequately stimulated by environmental factors." [] synonym: " Cpt8a" EXACT [] synonym: "cPlut" EXACT [] xref: UBERON:0008265 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0000480 ! late feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000520 name: metamorphic larva stage def: "The metamorphic larva stage consists essentially of the evagination of the echinoid rudiment. It is characterized by the execution of conspicuous and relatively abrupt physical changes that take place quite quickly, in about one hour, and during which the planktonic larva is transformed into a benthic juvenile. At that stage, the larva is settled on the substrate and is firmly attached to it by the primary podia of the rudiment. The ectodermal epithelium of its arms has started to collapse, making the spicules supporting the larval arms piercing through the epidermis. The larval mouth and anus have further closed, while in parallel, within the larva, the rudiment spines have lifted up thereby distending the vestibular wall and wide opening the vestibular pore. Following these movements, the rudiment has farther down accomplished and finalized its complete eversion, encapsulating the digestive tract and reaching the right side of the larval body. During this process, the genital plates and the associated pedicellariae and immature spines present on the right side of the larva have further completed the production of the aboral part of the adult body. At the end of metamorphosis, hence at the end of the metamorphic larva stage, the individual has thus become benthic, it is settled in the substrate, and it looks like an adult pentaradial sea urchin although it is smaller in size, deprived of a functional digestive system and sexually immature." [] synonym: " meta" EXACT [] synonym: "metamorphosis" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0000480 ! late feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000530 name: adulthood def: "Biological process during which changes occur in biological and psychological domains to generate a sexually mature animal." [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ECAO:0000440 ! larval development relationship: part_of ECAO:0000010 ! life cycle period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000540 name: juvenile period def: "Period during which a young individual, posing as a small adult, grows but remains unable to reproduce." [] xref: UBERON:0034919 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000480 ! late feeding larva period relationship: part_of ECAO:0000530 ! adulthood property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000550 name: early juvenile stage def: "The early juvenile is morphologically similar to both the late rudiment and a miniature sea urchin adult. Like the rudiment, it harbors five primary podia (or tube feet), five quartet of definitive spines, five pairs of immature spines located at the basis of the primary podia, 5 to 7 immature spines supported by the genital plates as well as 1 to 4 pedicellariae. Like the adult, it displays a pentarial symmetry and is settled on the substrate. An early juvenile is about 300 µm in diameter. On its aboral side, it still exhibits some remaining larval rods and tissues, although these will soon disappear. In addition, the plates forming its endoskeleton are still rather light and porous making it looking relatively clear, although it bears lots of red-pigmented cells. However, the postlarva is still deprived of a mouth and an anus, hence of a functional digestive tract. The early juvenile is thus endotrophic, meaning that its growth and development solely relies on energy derived from internal sources. Furthermore, the early juvenile is sexually immature." [] synonym: " endotrophic juvenile" EXACT [] synonym: " postlarva" EXACT [] synonym: "PLJuv" EXACT [] xref: UBERON:0007021 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000520 ! metamorphic larva stage relationship: part_of ECAO:0000540 ! juvenile period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000560 name: late juvenile stage def: "The late juvenile really looks like a small adult. The plates of its endoskeleton have by now densified providing it with a dark shell. In addition, it has finally developed a functional digestive tract. The digestive tract inherited from the larva has indeed by now undergone a complete reorganization, progressively bending within the perivisceral cavity to form two successive loops. The buccal plates and the aristotle lantern have further finished developing, creating a new mouth that has opened on the oral side at the center of the aristotle's lantern, while a new anus has also opened in the periproct, i.e. at the center of the five genital plates. The late juvenile can thus feed and starts growing in size, by grazing on the substrate. The late juvenile is exotrophic, meaning that its growth and development rely on energy derived from external sources. In addition, the primary podia have started to regress by that stage and will eventually disappear, while secondary podia have emerged and are functional, allowing the juvenile to move. Similarly, the immature spines have also started to be lost and be replaced by definitive spines. The genital plate CD has further differentiated into the madreporite and sphaeridia have formed. However, this individual is still sexually immature." [] synonym: "ExJuv" EXACT [] xref: UBERON:0007021 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0000540 ! juvenile period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000570 name: adult period def: "Period during which the animal reaches sexual maturity." [] xref: UBERON:0000066 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000540 ! juvenile period relationship: part_of ECAO:0000530 ! adulthood property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000580 name: adult stage def: "This stage corresponds to a fully formed pentaradial sea urchin that has reached sexual maturity. The gonads have developed within the perivisceral cavity and are connected to the outside by the genital pores pierced into the genital plates. The young adult has grown up to about several centimeters in diameter and is now producing gametes. Time after fertilization is unknown, between several months to one year depending on the sea urchin species and the rate and type of feeding." [] synonym: " gravid sea urchin" EXACT [] synonym: "sexual mature sea urchin" EXACT [] xref: UBERON:0000113 is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0000570 ! adult period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000590 name: very late blastula stage def: "The embryo is composed of about 800 cells and is surrounded by a fertilization envelope. The wall of the embryo is thinner and smoother than at previous stages. The vegetal plate has not formed. Many cells are ciliated but the embryo has not begun to rotate within the fertilization envelope. Note for euechinoid indirect developers: molecular labeling typically indicates the presence of 32 large micromere descendants and 4 small micromere descendants at this stage." [] synonym: "vLB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000310 ! late swimming blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000600 name: vegetal plate stage def: "Stage when the vegetal plate is apparent but primary mesenchyme cells (PMCs) have not started to ingress. Embryos are motile due ciliary beating but have not completed hatching." [] synonym: "VP" EXACT [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000610 name: open mouth stage def: "open mouth stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000620 name: early prism stage def: "early prism stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000630 name: late prism stage def: "late prism stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000640 name: early pluteus stage def: "early pluteus stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000630 ! late prism stage relationship: part_of ECAO:0000450 ! early feeding larva period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000650 name: early organogenesis stage def: "early organogenesis stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000660 name: mid-organogenesis stage def: "mid-organogenesis stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000650 ! early organogenesis stage relationship: part_of ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000670 name: late organogenesis stage def: "late organogenesis stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000660 ! mid-organogenesis stage relationship: part_of ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000680 name: very late organogenesis stage def: "very late organogenesis stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000670 ! late organogenesis stage relationship: part_of ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000690 name: mesenchyme blastula stage def: "mesenchyme blastula stage" [] is_a: BFO:0000003 ! occurrent relationship: immediately_preceded_by ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000700 name: motile blastula stage def: "motile blastula stage" [] synonym: "MotB" EXACT [] is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000240 ! blastula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0000710 name: invagination episode def: "invagination episode" [] is_a: BFO:0000003 ! occurrent relationship: part_of ECAO:0000320 ! gastrula period property_value: oio:hasOBONamespace "ecao_developmental_stage" xsd:string [Term] id: ECAO:0103500 name: echinoderm anatomy def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [] xref: UBERON:0001062 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103510 name: anatomical structure def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome" [] xref: UBERON:0000061 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103520 name: anatomical system def: "A system that has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity. Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function" [] synonym: " body system" EXACT [] synonym: " connected anatomical system" EXACT [] synonym: "organ system" EXACT [] xref: UBERON:0000467 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103530 name: anatomical region def: "A region of the whole organism without well-defined compartmental boundaries" [] synonym: "organism subdivision" EXACT [] xref: UBERON:0000475 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103540 name: anatomical space xref: UBERON:0000464 is_a: BFO:0000004 ! independent continuant relationship: existence_ends_during ECAO:0000580 ! adult stage relationship: existence_starts_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103500 ! echinoderm anatomy property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103550 name: whole organism def: "Anatomical structure that is an individual member of a species and consists of one cell or more" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103560 name: multicellular organism def: "Anatomical structure that is an individual member of a species and consists of more than one cell" [] xref: UBERON:0000468 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000155 ! stage 2 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103570 name: embryo def: "Anatomical entity that comprises the animal in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems" [] xref: UBERON:0000922 is_a: ECAO:0103560 ! multicellular organism relationship: existence_ends_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103580 name: larva xref: UBERON:0002548 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103570 ! embryo relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103590 name: juvenile xref: UBERON:0034919 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103580 ! larva relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103600 name: adult xref: UBERON:0007023 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103590 ! juvenile relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103610 name: digestive system def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [] xref: UBERON:0001007 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103620 name: embryonic digestive system def: "The gastrointestinal tract that is being formed during embryonic development starting with the formation of the primitive gut tube (or archenteron)" [] is_a: ECAO:0103610 ! digestive system relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000380 ! blastopore formation stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103630 name: larval digestive system def: "Organ system responsible for the food uptake and processing in the larva" [] is_a: ECAO:0103610 ! digestive system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103620 ! embryonic digestive system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103640 name: juvenile digestive system is_a: ECAO:0103610 ! digestive system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103650 name: adult digestive system def: "Anatomical system that processes ingested substances in the adult" [] is_a: ECAO:0103610 ! digestive system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103640 ! juvenile digestive system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103660 name: immune system xref: UBERON:0002405 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103670 name: embryonic immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103680 name: larval immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103690 name: juvenile immune system is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103700 name: adult immune system is_a: ECAO:0103660 ! immune system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103710 name: reproductive system def: "Anatomical system that has as its parts the organs concerned with reproduction, i.e. the male and female gonads." [] xref: UBERON:0000990 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103720 name: nervous system xref: UBERON:0001016 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103730 name: embryonic nervous system def: "The sum of all the structures in the embryo that will develop into the larval nervous system" [] is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103740 name: larval nervous system def: "The sum of all the neural structures present in the larva" [] is_a: ECAO:0103720 ! nervous system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103730 ! embryonic nervous system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103750 name: juvenile nervous system is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103760 name: adult nervous system xref: UBERON:6003559 is_a: ECAO:0103720 ! nervous system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103750 ! juvenile nervous system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103770 name: muscular system xref: UBERON:0000383 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103780 name: larval muscular system is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103790 name: juvenile muscular system is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103800 name: adult muscular system xref: UBERON:6003218 is_a: ECAO:0103770 ! muscular system is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103790 ! juvenile muscular system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103810 name: endoskeleton def: "Internal support structure of an animal composed of mineralized tissue. It gives shape, support and protection to the body." [] xref: UBERON:0001434 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103820 name: embryonic endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103830 name: larval endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103840 name: rudiment endoskeleton synonym: "skeletal rudiment" EXACT [] is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103850 name: juvenile endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103860 name: adult endoskeleton is_a: ECAO:0103810 ! endoskeleton relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103870 name: water vascular system def: "The water vascular system is a hydraulic system used by sea urchins for locomotion, food and waste transportation, and respiration. The system is composed of canals connecting numerous tube feet." [] xref: UBERON:0008251 is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103880 name: hemal system def: "The hemal system contains the blood. It is composed of a complex network of vessels mainly located around the gut." [] synonym: "haemal system" EXACT [] is_a: ECAO:0103520 ! anatomical system relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103890 name: animal hemisphere def: "Anatomical region that corresponds to the upper half of the embryo, which later is composed of the mesomeres, and ultimately encompasses the presumptive ectoderm" [] synonym: " upper half" EXACT [] synonym: " upper hemisphere" EXACT [] synonym: "animal half" EXACT [] xref: UBERON:0012284 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103900 name: vegetal hemisphere def: "Anatomical region that corresponds to the lower half of the embryo, which later is composed of the macromeres and the micromeres, and ultimately encompasses the endoderm and mesoderm" [] synonym: " lower half" EXACT [] synonym: " lower hemisphere" EXACT [] synonym: "vegetal half" EXACT [] xref: UBERON:0012285 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103910 name: cell cortex is_a: ECAO:0104040 ! cell part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103920 name: cleavage furrow is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103930 name: animal cortex def: "Cell component comprising the outermost layer of the animal region of the oocyte. It consists of a phospholipid bilayer and associated proteins" [] is_a: ECAO:0103910 ! cell cortex relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103940 name: vegetal cortex def: "Cell component comprising the outermost layer of the vegetal region of the oocyte. It consists of a phospholipid bilayer and associated proteins" [] is_a: ECAO:0103910 ! cell cortex relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103950 name: animal pole def: "The apical region of the animal hemisphere" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103960 name: vegetal pole def: "The apical most region of the vegetal hemisphere. Once cleavages have started the vegetal pole is characterized by the presence of the micromeres initially and then that of the small micromeres" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103970 name: animal pole domain synonym: " animal plate" EXACT [] synonym: " anterior neuroectoderm" EXACT [] synonym: " apical plate" EXACT [] synonym: " neurogenic ectoderm" EXACT [] synonym: "apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000250 ! very early blastula stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103980 name: blastopore xref: UBERON:0000100 is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103620 ! embryonic digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0103990 name: blastopore lip xref: UBERON:3010455 is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103980 ! blastopore property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104000 name: bottle cell is_a: ECAO:0104010 ! embryonic cell relationship: existence_ends_during ECAO:0000286 ! stage 12 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104010 name: embryonic cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000155 ! stage 2 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104020 name: vegetal plate is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000286 ! stage 12 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104030 name: cell def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane" [] is_a: ECAO:0103510 ! anatomical structure property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104040 name: cell part def: "Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104050 name: digestive system element def: "Any of the organs or elements that are part of the digestive system" [] xref: UBERON:0013765 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104060 name: skeletal element xref: UBERON:0004765 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104070 name: embryonic structure def: "Any anatomical structure that is part of an embryo" [] xref: UBERON:0002050 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104080 name: larval structure def: "Any anatomical structure that is part of a larva" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104090 name: juvenile structure def: "Any anatomical structure that is part of a juvenile" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104100 name: adult structure def: "Any anatomical structure that is part of an adult" [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104110 name: tissue xref: UBERON:0000479 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104120 name: rudiment synonym: " imaginal adult rudiment" EXACT [] synonym: "adult rudiment" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104130 name: rudiment structure is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104140 name: non-rudiment adult structure is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104147 name: intracellular part is_a: ECAO:0104040 ! cell part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104148 name: cytoskeleton is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104150 name: microtubule is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104160 name: nucleus def: "A membrane-bounded organelle of in which chromosomes are housed and replicated. In most cells, it contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some specialized cell types, RNA metabolism or DNA replication may be absent" [] is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104168 name: oocyte def: "A female haploid germ cell." [] is_a: ECAO:0104580 ! gamete relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104170 name: germinal vesicle def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity" [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104180 name: equatorial pigment band def: "The subequatorial accumulation of pigment granules (the so-called ‘pigment band’) in eggs or early stage embryos, which constitutes an unambiguous marker of animal-vegetal polarity" [] synonym: " pigmented band" EXACT [] synonym: "pigment band" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104190 name: cytoplasm def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures" [] is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104200 name: centrosome is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104210 name: mitotic spindle is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104220 name: meiotic spindle is_a: ECAO:0104147 ! intracellular part relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104230 name: fertilization envelope def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release" [] synonym: "fertilization membrane" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104247 name: spermatozoid def: "A mature male germ cell" [] synonym: " male gamete" EXACT [] synonym: " mature sperm cell" EXACT [] synonym: " spermatozoa" EXACT [] synonym: " spermatozoan" EXACT [] synonym: "sperm" EXACT [] is_a: ECAO:0104580 ! gamete relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104248 name: aster synonym: " mitotic aster" EXACT [] synonym: "spindle aster" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104250 name: sperm aster synonym: "spermatozoid aster" EXACT [] is_a: ECAO:0104248 ! aster relationship: existence_ends_during ECAO:0000120 ! mature spermatozoid stage relationship: existence_starts_during ECAO:0000120 ! mature spermatozoid stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104270 name: acellular membrane xref: UBERON:0005764 is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000090 ! mature oocyte stage relationship: existence_starts_during ECAO:0000090 ! mature oocyte stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104280 name: vitelline membrane synonym: " vitelline envelope" EXACT [] synonym: "vitelline layer" EXACT [] xref: UBERON:0003125 is_a: ECAO:0104270 ! acellular membrane relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104300 name: hyaline layer synonym: "hyaline membrane" EXACT [] is_a: ECAO:0104270 ! acellular membrane relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104310 name: microvillus is_a: ECAO:0104040 ! cell part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104320 name: apical lamina synonym: "fibropellin layer" EXACT [] is_a: ECAO:0104270 ! acellular membrane relationship: part_of ECAO:0104300 ! hyaline layer property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104330 name: secretory vesicle is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104340 name: cilium is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104350 name: filopodium is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104360 name: basal lamina xref: UBERON:0000482 is_a: ECAO:0104270 ! acellular membrane relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104370 name: basal laminar vesicle synonym: " basal vesicle" EXACT [] synonym: "basal lamina vesicle" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104380 name: apical vesicle is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104390 name: cortical granule synonym: "cortical vesicle" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104400 name: echinonectin vesicle synonym: " echinonectin granule" EXACT [] synonym: "nectosome" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104410 name: mitochondrion is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104420 name: actin cytoskeleton is_a: ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104430 name: actin filament synonym: " F-actin filament" EXACT [] synonym: "microfilament" EXACT [] is_a: ECAO:0104147 ! intracellular part relationship: part_of ECAO:0104420 ! actin cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104440 name: nuclear part is_a: ECAO:0104147 ! intracellular part relationship: existence_starts_during ECAO:0000090 ! mature oocyte stage relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104450 name: nucleoplasm is_a: ECAO:0104440 ! nuclear part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104460 name: nuclear envelope is_a: ECAO:0104440 ! nuclear part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104470 name: endoplasmic reticulum is_a: ECAO:0104147 ! intracellular part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104480 name: spermatozoid entry point is_a: ECAO:0104040 ! cell part relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104490 name: plasma membrane synonym: "cell membrane" EXACT [] is_a: ECAO:0104040 ! cell part relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104500 name: polar body def: "A small cell formed by the meiotic division of an oocyte" [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000135 ! stage 1 relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104510 name: spermatozoid part synonym: "sperm part" EXACT [] is_a: ECAO:0104040 ! cell part relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104520 name: spermatozoid head def: "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome." [] is_a: ECAO:0104510 ! spermatozoid part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104530 name: spermatozoid flagellum def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid" [] synonym: "sperm tail" EXACT [] is_a: ECAO:0104510 ! spermatozoid part property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104540 name: acrosomal vesicle def: "An organelle that develops over the anterior half of the head in the spermatozoa" [] synonym: "acrosome" EXACT [] is_a: ECAO:0104330 ! secretory vesicle relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104520 ! spermatozoid head property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104548 name: small micromere descendant cell synonym: "presumptive primordial germ cell" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104720 ! small micromere relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104550 name: presumptive primordial germ cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104548 ! small micromere descendant cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104560 name: primordial germ cell is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104570 name: germ cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104580 name: gamete is_a: ECAO:0104570 ! germ cell relationship: existence_ends_during ECAO:0000020 ! gametogenesis relationship: existence_starts_during ECAO:0000020 ! gametogenesis property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104600 name: immature occyte synonym: "immature egg" EXACT [] is_a: ECAO:0104168 ! oocyte relationship: existence_ends_during ECAO:0000080 ! fully grown oocyte with no nucleus stage relationship: existence_starts_during ECAO:0000040 ! previtellogenic primary oocyte stage relationship: part_of ECAO:0104560 ! primordial germ cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104610 name: mature oocyte def: "A mature female gamet that has entered meiosis." [] synonym: " female gamete" EXACT [] synonym: " female germ cell" EXACT [] synonym: " unfertilized egg" EXACT [] synonym: "egg" EXACT [] is_a: ECAO:0104168 ! oocyte relationship: develops_from ECAO:0104600 ! immature occyte relationship: part_of ECAO:0104570 ! germ cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104630 name: blastomere def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)" [] synonym: "blastoderm cell" EXACT [] is_a: ECAO:0104010 ! embryonic cell relationship: existence_ends_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104640 name: blastomere of 2-cell embryo is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000160 ! 2-cell stage relationship: existence_starts_during ECAO:0000160 ! 2-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104650 name: blastomere of 4-cell embryo is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000170 ! 4-cell stage relationship: existence_starts_during ECAO:0000170 ! 4-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104660 name: mesomere def: "Intermediate size blastomere forming the animal hemisphere of the cleaving embryo" [] synonym: "mesomeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000185 ! stage 5 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104670 name: macromere def: "Larger blastomere of the vegetal hemisphere of the cleaving embryo located below the equator" [] synonym: "macromeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000185 ! stage 5 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104678 name: cell tier synonym: "blastomere tier" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000175 ! stage 4 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104680 name: macromere daughter cell tier is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000195 ! stage 6 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104690 name: micromere def: "Small blastomere of the vegetal hemisphere of the cleaving embryo located at to the vegetal pole" [] synonym: "micromeres" EXACT [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000195 ! stage 6 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104700 name: large micromere is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104690 ! micromere relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104710 name: large micromere descendant cell synonym: " presumptive PMC" EXACT [] synonym: " presumptive primary mesenchyme cell" EXACT [] synonym: " presumptive skeletogenic mesenchyme cell" EXACT [] synonym: "large micromere progeny" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104720 name: small micromere synonym: "SM" EXACT [] is_a: ECAO:0104630 ! blastomere is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104690 ! micromere relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104740 name: presumptive neuron def: "A progenitor cell of the nervous system that will develop into a neuron" [] synonym: "neuronal progenitor cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104750 name: animal pole domain presumptive neuron synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104760 name: ectoderm presumptive neuron synonym: "ectoderm neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104770 name: ciliary band presumptive neuron synonym: "ciliary band neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104780 name: endoderm associated presumptive neuron synonym: "endoderm associated neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104790 name: neuron synonym: "nerve cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104800 name: larval neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104810 name: serotonergic neuron is_a: ECAO:0104790 ! neuron relationship: develops_from ECAO:0104750 ! animal pole domain presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104820 name: synaptotagmin-B neuron is_a: ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104830 name: dopaminergic neuron is_a: ECAO:0104790 ! neuron relationship: develops_from ECAO:0104760 ! ectoderm presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104840 name: GABAergic neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104850 name: sensory neuron synonym: "sensory cell" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104860 name: biopolar neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104870 name: multipolar neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104878 name: neural structure synonym: "neuronal structure" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103720 ! nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104880 name: axon tract synonym: " axon bundle" EXACT [] synonym: "axonal tract" EXACT [] xref: UBERON:0001018 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000430 ! prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104900 name: ciliary band neuron synonym: "peripheral neuron" EXACT [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104770 ! ciliary band presumptive neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104908 name: ectoderm def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [] xref: UBERON:0000924 is_a: ECAO:0105150 ! germ layer property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104910 name: presumptive ciliary band cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000422 ! stage 16 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104920 name: endoderm associated neuron is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104780 ! endoderm associated presumptive neuron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104930 name: ganglion xref: UBERON:0000045 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104940 name: apical ganglion synonym: "apical organ" EXACT [] is_a: ECAO:0104930 ! ganglion is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103970 ! animal pole domain relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104950 name: adult neuron is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104960 name: circumoral nerve ring is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104970 name: enteric nerve plexus synonym: " digestive nerve plexus" EXACT [] synonym: "enteric plexus" EXACT [] xref: UBERON:0000429 is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104980 name: radial nerve cord is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0104990 name: primary podia associated neuron is_a: ECAO:0104950 ! adult neuron relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105000 name: secondary podia associated neuron is_a: ECAO:0104950 ! adult neuron relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105010 name: definitive spine associated neuron is_a: ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105020 name: pedicellaria associated neuron is_a: ECAO:0104950 ! adult neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105030 name: basiepidermal nerve plexus is_a: ECAO:0104878 ! neural structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103760 ! adult nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105050 name: animal quartet def: "Group of four cells of equal size forming the animal hemisphere of an eight-cell stage embryo" [] is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105060 name: vegetal quartet def: "Group of four cells of equal size forming the vegetal hemisphere of an eight-cell stage embryo" [] is_a: ECAO:0104678 ! cell tier relationship: existence_ends_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105070 name: animal tier 1 synonym: "an1" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105080 name: animal tier 2 synonym: "an2" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105090 name: vegetal tier 1 synonym: " ectoendoderm" EXACT [] synonym: "veg1" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000255 ! stage 8 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105100 name: vegetal tier 2 synonym: " endomesoderm" EXACT [] synonym: "veg2" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000255 ! stage 8 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105110 name: vegetal tier 1 upper synonym: " presumptive vegetal ectoderm" EXACT [] synonym: " veg1 upper" EXACT [] synonym: "veg1U" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105120 name: vegetal tier 1 lower synonym: " veg1 lower" EXACT [] synonym: "veg1L" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105130 name: vegetal tier 2 upper synonym: " veg2 upper" EXACT [] synonym: "veg2U" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105140 name: vegetal tier 2 lower synonym: " presumptive non-skeletogenic mesoderm" EXACT [] synonym: " veg2 lower" EXACT [] synonym: "veg2L" EXACT [] is_a: ECAO:0104678 ! cell tier is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_starts_during ECAO:0000265 ! stage 9 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105150 name: germ layer synonym: " embryonic germ layer" EXACT [] synonym: "primary germ layer" EXACT [] xref: UBERON:0000923 is_a: ECAO:0104070 ! embryonic structure relationship: existence_starts_during ECAO:0000286 ! stage 12 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105158 name: embryonic tissue xref: UBERON:0005291 is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105160 name: presumptive ectoderm xref: UBERON:0006601 is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104660 ! mesomere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105180 name: animal ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105190 name: vegetal ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000600 ! vegetal plate stage relationship: existence_starts_during ECAO:0000260 ! early blastula stage relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105200 name: ventral ectoderm synonym: "oral ectoderm" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105210 name: dorsal ectoderm synonym: "aboral ectoderm" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105220 name: ectoendoderm synonym: " veg1" EXACT [] synonym: "vegetal tier 1" EXACT [] is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105090 ! vegetal tier 1 relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105230 name: endomesoderm synonym: " mesoendoderm" EXACT [] synonym: " veg2" EXACT [] synonym: "vegetal tier 2" EXACT [] is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105240 name: inner animal pole domain synonym: "inner apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105250 name: outer animal pole domain synonym: "outer apical pole domain" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105260 name: central ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105270 name: border ectoderm synonym: "BE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105280 name: near-apical ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000370 ! invagination phase relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105290 name: apical ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000240 ! blastula period relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105300 name: veg1-lateral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000370 ! invagination phase relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105310 name: veg-1 oral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000370 ! invagination phase relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105320 name: lateral ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105330 name: right lateral ectoderm is_a: ECAO:0105320 ! lateral ectoderm relationship: existence_ends_during ECAO:0000370 ! invagination phase relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105340 name: left lateral ectoderm is_a: ECAO:0105320 ! lateral ectoderm relationship: existence_ends_during ECAO:0000370 ! invagination phase relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105350 name: arm tip ectoderm is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105360 name: dorsal arm tip ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105370 name: ventral arm tip ectoderm is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105380 name: apical tuft is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105400 name: larval tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105410 name: rudiment tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105420 name: juvenile tissue is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103590 ! juvenile property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105430 name: adult tissue is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105440 name: presumptive stomodeum is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105450 name: stomodeum synonym: "presumptive mouth" EXACT [] xref: UBERON:0000930 is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105440 ! presumptive stomodeum relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105460 name: ciliary band is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105470 name: oral hood ciliary band is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105480 name: arm ciliary band is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105490 name: animal pole ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105500 name: vegetal ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105510 name: lateral ciliary band is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105520 name: oral hood synonym: " PL" EXACT [] synonym: " preoral lobe" EXACT [] synonym: "oh" EXACT [] is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105530 name: apex is_a: ECAO:0104080 ! larval structure relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105540 name: larval arm is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105550 name: right anterolateral arm synonym: " ALA" EXACT [] synonym: "AL" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105560 name: left anterolateral arm synonym: " ALA" EXACT [] synonym: "AL" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105570 name: right postoral arm synonym: "PO" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105580 name: left postoral arm synonym: "PO" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105590 name: right posterodorsal arm synonym: "PD" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105600 name: left posterodorsal arm synonym: "PD" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105610 name: right preoral arm synonym: " PRO" EXACT [] synonym: "PR" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105620 name: left preoral arm synonym: " PRO" EXACT [] synonym: "PR" EXACT [] is_a: ECAO:0105540 ! larval arm relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105628 name: spicule rudiment is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105630 name: spicule granule synonym: "spicule dot" EXACT [] is_a: ECAO:0105628 ! spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105650 name: triradiate spicule rudiment synonym: "spicule primordium" EXACT [] is_a: ECAO:0105628 ! spicule rudiment is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105660 name: right ventrolateral triradiate spicule rudiment synonym: "triradiate spicule" EXACT [] is_a: ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105670 name: left ventrolateral triradiate spicule rudiment is_a: ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105680 name: hexaradiate spicule rudiment synonym: "hexaradiate spicule" EXACT [] is_a: ECAO:0105628 ! spicule rudiment is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105690 name: larval spicule def: "A triradiate or hexaradiate minute calcareous skeletal element that initiates most if not all skeletal structures found within the sea urchin embryo, larva and adult." [] synonym: "primary triradiate skeletal rudiment" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105698 name: embryonic skeletogenic mesenchyme def: "The embryonic tissue made up of loosely connected mesoderm cells that will produce all of the skeletal elements." [] synonym: " primary mesenchyme" EXACT [] synonym: "SM" EXACT [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106220 ! embryonic skeletogenic mesoderm relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105700 name: skeletal rod synonym: "spicule rod" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105710 name: anonymous rod is_a: ECAO:0105700 ! skeletal rod relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105720 name: right anonymous rod is_a: ECAO:0105710 ! anonymous rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105730 name: left anonymous rod is_a: ECAO:0105710 ! anonymous rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105738 name: right dorsoventral connecting rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105740 name: right anterolateral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105738 ! right dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105748 name: left dorsoventral connecting rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105750 name: left anterolateral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105748 ! left dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105760 name: right postoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105720 ! right anonymous rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105770 name: left postoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105730 ! left anonymous rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105780 name: right posterodorsal rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105790 name: left posterodorsal rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105798 name: dorsal arch is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105800 name: right preoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105798 ! dorsal arch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105810 name: left preoral rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105798 ! dorsal arch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105850 name: right ventral transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105660 ! right ventrolateral triradiate spicule rudiment relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105860 name: left ventral transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105670 ! left ventrolateral triradiate spicule rudiment relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105868 name: posterior tip of body rod is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105870 name: scheitel synonym: "body rod end" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105880 name: body rod is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105890 name: left body rod is_a: ECAO:0105880 ! body rod is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105900 name: right body rod is_a: ECAO:0105880 ! body rod is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105920 name: posterior tip of left body rod is_a: ECAO:0105868 ! posterior tip of body rod relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105930 name: posteror tip of right body rod is_a: ECAO:0105868 ! posterior tip of body rod relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105940 name: right recurrent rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105738 ! right dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105950 name: left recurrent rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105748 ! left dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105960 name: posterior transverse rod is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103830 ! larval endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105970 name: mouth xref: UBERON:0000165 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105980 name: larval mouth is_a: ECAO:0105970 ! mouth is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105450 ! stomodeum relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0105990 name: anus xref: UBERON:0001245 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106000 name: larval anus is_a: ECAO:0105990 ! anus is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103980 ! blastopore relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106010 name: presumptive endoderm synonym: "prospective endoderm" EXACT [] xref: UBERON:0006595 is_a: ECAO:0105158 ! embryonic tissue relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106020 name: endoderm xref: UBERON:0000925 is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106010 ! presumptive endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106030 name: archenteron synonym: " primitive gut" EXACT [] synonym: "embryonic gut" EXACT [] xref: UBERON:0004735 is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106040 name: hindgut xref: UBERON:0001046 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106050 name: dorsal hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106060 name: ventral hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106070 name: midgut xref: UBERON:0001045 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106080 name: ventral midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106090 name: dorsal midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106100 name: anterior midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106110 name: posterior midgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106120 name: anterior hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106130 name: posterior hindgut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106140 name: foregut synonym: "tip of the digestive tract" EXACT [] xref: UBERON:0001041 is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106150 name: ventral foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106160 name: dorsal foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106170 name: anterior foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106180 name: posterior foregut is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106190 name: tip of archenteron synonym: "archenteron roof" EXACT [] xref: UBERON:3010432 is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106200 name: presumptive mesoderm synonym: "prospective mesoderm" EXACT [] xref: UBERON:0006603 is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000185 ! stage 5 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106210 name: mesoderm xref: UBERON:0000926 is_a: ECAO:0105150 ! germ layer is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106220 name: embryonic skeletogenic mesoderm def: "The subset of the embryonic mesoderm that will later give rise to the skeletogenic mesenchyme and embryonic skeleton." [] is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000590 ! very late blastula stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106240 name: embryonic skeletogenic mesenchyme cell synonym: " primary mesenchyme cell" EXACT [] synonym: "PMC" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104700 ! large micromere relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0105698 ! embryonic skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106250 name: syncytium synonym: " multinucleated cell" EXACT [] synonym: " syncytial cell" EXACT [] synonym: " syncytium" EXACT [] synonym: "multinucleate cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106260 name: embryonic skeletogenic mesenchyme syncytium def: "Anatomical structure composed of skeletogenic mesenchyme cells that have fused to form a single syncytial network." [] is_a: ECAO:0106250 ! syncytium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106270 name: subequatorial skeletogenic mesenchyme ring synonym: " PMC ring" EXACT [] synonym: " primary mesenchyme cell ring" EXACT [] synonym: " subequatorial PMC ring" EXACT [] synonym: " subequatorial primary mesenchyme cell ring" EXACT [] synonym: " subequatorial SM ring" EXACT [] synonym: "SM ring" EXACT [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106260 ! embryonic skeletogenic mesenchyme syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106280 name: ventral skeletogenic mesenchyme chain def: "Subpopulation of skeletogenic mesenchyme forming a chain on the oral (i.e. ventral) side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106290 name: dorsal skeletogenic mesenchyme chain def: "Subpopulation of skeletogenic mesenchyme forming a chain on the aboral (i.e. dorsal) side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106300 name: right ventrolateral skeletogenic mesenchyme cluster def: "Subpopulation of skeletogenic mesenchyme forming a cluster (i.e. a group of cells) in the ventrolateral region of the embryo." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106310 name: left ventrolateral skeletogenic mesenchyme cluster is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106320 name: lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain on either side of the developing digestive tract, along the blastocoel wall and towards the animal pole." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000400 ! mid-gastrula stage relationship: part_of ECAO:0106260 ! embryonic skeletogenic mesenchyme syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106330 name: right lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain along the blastocoel wall towards the animal pole on the right side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0106320 ! lateral chain of skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106340 name: left lateral chain of skeletogenic mesenchyme def: "Subpopulation of skeletogenic mesenchyme forming a chain along the blastocoel wall towards the animal pole on the left side of the embryo." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0106320 ! lateral chain of skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106350 name: embryonic non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000590 ! very late blastula stage relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106360 name: ventral non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106370 name: dorsal non-skeletogenic mesoderm is_a: ECAO:0105158 ! embryonic tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000330 ! mesenchyme blastula phase relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106380 name: embryonic non-skeletogenic mesenchyme synonym: " NSM" EXACT [] synonym: "secondary mesenchyme" EXACT [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106390 name: embryonic non-skeletogenic mesenchyme cell synonym: " secondary mesenchyme cell" EXACT [] synonym: "SMC" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106380 ! embryonic non-skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106400 name: larval non-skeletogenic mesenchyme is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106410 name: larval non-skeletogenic mesenchyme cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106400 ! larval non-skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106420 name: presumptive blastocoelar cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106430 name: presumptive pigment cell synonym: " presumptive immunocyte" EXACT [] synonym: "presumptive pigmented cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106350 ! embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106440 name: pigment cell def: "a cell that contains red coloring matter" [] synonym: " pigmented immunocyte" EXACT [] synonym: "pigmented cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106430 ! presumptive pigment cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106450 name: embryonic pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000390 ! early gastrula stage relationship: part_of ECAO:0103670 ! embryonic immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106460 name: larval pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106470 name: juvenile pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103690 ! juvenile immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106480 name: rudiment pigment cell is_a: ECAO:0106440 ! pigment cell relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0104120 ! rudiment property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106490 name: blastocoelar cell is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106420 ! presumptive blastocoelar cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106500 name: globular cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106510 name: filopodial cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106520 name: ovoid cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106530 name: amoeboid cell is_a: ECAO:0106490 ! blastocoelar cell relationship: part_of ECAO:0103680 ! larval immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106540 name: muscle precursor cell synonym: "presumptive muscle cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000460 ! early pluteus larva stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106550 name: muscle is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106560 name: larval muscle synonym: "contractile muscle" EXACT [] is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0103780 ! larval muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106570 name: rudiment muscle is_a: ECAO:0105410 ! rudiment tissue relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106580 name: juvenile muscle is_a: ECAO:0105420 ! juvenile tissue relationship: part_of ECAO:0103790 ! juvenile muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106590 name: adult muscle is_a: ECAO:0105430 ! adult tissue relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103800 ! adult muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106600 name: blastocoel xref: UBERON:0000090 is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106610 name: sphincter is_a: ECAO:0104050 ! digestive system element relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106620 name: pyloric sphincter synonym: "midgut-hindgut constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106630 name: cardiac sphincter synonym: "foregut-midgut constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106640 name: anal sphincter synonym: "hindgut-ectoderm constriction" EXACT [] is_a: ECAO:0106610 ! sphincter is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106650 name: sphincter muscle xref: UBERON:0004590 is_a: ECAO:0106550 ! muscle is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106660 name: sphincter muscle cell synonym: "myoepithelial cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_starts_during ECAO:0000470 ! 4-arm pluteus larva stage relationship: part_of ECAO:0106650 ! sphincter muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106670 name: pyloric sphincteric muscle synonym: "pyloric sphincter" EXACT [] xref: UBERON:0001202 is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106680 name: cardiac sphincteric muscle synonym: "cardiac sphincter" EXACT [] is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106690 name: anal sphincteric muscle synonym: "anal sphincter" EXACT [] xref: UBERON:0004916 is_a: ECAO:0106650 ! sphincter muscle relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106700 name: larval esophagus is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106140 ! foregut relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106708 name: circumesophageal muscle is_a: ECAO:0106560 ! larval muscle is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106700 ! larval esophagus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106710 name: circumesophageal muscle cell synonym: "presumptive circumesophageal muscle cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106708 ! circumesophageal muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106730 name: larval stomach is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106070 ! midgut relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106740 name: larval intestine is_a: ECAO:0104050 ! digestive system element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106040 ! hindgut relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103630 ! larval digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106750 name: larval skeletogenic mesenchyme def: "The mesenchyme cells that produce new skeletal elements (i.e., the posterodorsal rods, dorsal arch, and preoral rods) in the larva after feeding begins" [] is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106760 name: larval skeletogenic mesenchyme cell is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0106750 ! larval skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106770 name: coelom xref: UBERON:0011997 is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106190 ! tip of archenteron relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106780 name: unpaired coelomic pouch synonym: "unpaired coelomic rudiment" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000430 ! prism stage relationship: existence_starts_during ECAO:0000430 ! prism stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106790 name: right coelomic pouch is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106800 name: left coelomic pouch synonym: "left coelomic sac" EXACT [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106810 name: right coelomic constriction is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0106790 ! right coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106820 name: left coelomic constriction is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106780 ! unpaired coelomic pouch relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106828 name: larval epithelium is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000520 ! metamorphic larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106830 name: vestibule synonym: "amniotic sac" EXACT [] is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105200 ! ventral ectoderm relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106840 name: oral epithelium synonym: " circumoral ectoderm" EXACT [] synonym: " circumoral epithelium" EXACT [] synonym: "oral epidermis" EXACT [] xref: UBERON:0002424 is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106850 name: aboral epithelium is_a: ECAO:0105400 ! larval tissue relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000460 ! early pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106858 name: left lateral field def: "The left lateral field is the lateral field located on the left side of the larva" [] is_a: ECAO:0107100 ! lateral field property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106860 name: vestibular pore def: "Opening located in the left lateral field" [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106858 ! left lateral field relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000510 ! competent pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106868 name: axocoel synonym: "anterior coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106870 name: left axocoel is_a: ECAO:0106868 ! axocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106880 name: axial coelom is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106870 ! left axocoel relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106890 name: hydrocoel synonym: "central coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106910 name: somatocoel synonym: "posterior coelom" EXACT [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106920 name: left hydrocoel is_a: ECAO:0106890 ! hydrocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106930 name: left somatocoel is_a: ECAO:0106910 ! somatocoel relationship: develops_from ECAO:0106800 ! left coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106940 name: right axohydrocoel synonym: "anterior sac" EXACT [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106790 ! right coelomic pouch relationship: existence_ends_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106950 name: right somatocoel is_a: ECAO:0106910 ! somatocoel relationship: develops_from ECAO:0106790 ! right coelomic pouch property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106958 name: axial complex is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106960 name: stone canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106970 name: ring canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106920 ! left hydrocoel relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106980 name: radial canal is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106920 ! left hydrocoel relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0106990 name: primary pore canal synonym: "hydropore canal" EXACT [] is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106380 ! embryonic non-skeletogenic mesenchyme relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107000 name: hydropore is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107010 name: right axocoel is_a: ECAO:0106868 ! axocoel relationship: develops_from ECAO:0106940 ! right axohydrocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107020 name: right hydrocoel is_a: ECAO:0106890 ! hydrocoel relationship: develops_from ECAO:0106940 ! right axohydrocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107040 name: axial sinus is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107020 ! right hydrocoel relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107050 name: axial organ is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107060 name: dorsal sac is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0106958 ! axial complex property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107070 name: ciliated epaulette is_a: ECAO:0104080 ! larval structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105460 ! ciliary band relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000490 ! 6-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107080 name: anterior ciliated epaulette is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107070 ! ciliated epaulette property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107090 name: posterior ciliated epaulette is_a: ECAO:0104080 ! larval structure relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107070 ! ciliated epaulette property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107100 name: lateral field def: "The lateral field is located in the aboral ectoderm of the larva. It separates the anterior and posterior pairs of epaulettes" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000510 ! competent pluteus larva stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0106828 ! larval epithelium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107120 name: right lateral field def: "The right lateral field is the lateral field located on the right side of the larva" [] is_a: ECAO:0107100 ! lateral field property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107140 name: ambulacral plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107150 name: adult skeletogenic mesenchyme def: "The mesenchyme cells that produce biomineralized elements (e.g., spines, test plates, and teeth) in the juvenile and adult." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103600 ! adult property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107160 name: interambulacral plate synonym: "int" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107170 name: ambulacra is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107180 name: interambulacra is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107190 name: genital plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107200 name: appendage is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107210 name: pedicellaria xref: UBERON:0008261 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107220 name: ocular plate synonym: "terminal plate" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107230 name: buccal plate is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107240 name: genital plate AB is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107250 name: genital plate BC is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107260 name: genital plate CD is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107270 name: genital plate DE is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107280 name: genital plate EA is_a: ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107290 name: podia synonym: "tube foot" EXACT [] xref: UBERON:0008247 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107300 name: primary podia synonym: "primary tube foot" EXACT [] is_a: ECAO:0107290 ! podia relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107310 name: disk of primary podia is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage relationship: part_of ECAO:0107300 ! primary podia property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107320 name: secondary podia synonym: "secondary tube foot" EXACT [] is_a: ECAO:0107290 ! podia relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107330 name: disk of secondary podia is_a: ECAO:0104060 ! skeletal element relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107320 ! secondary podia property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107340 name: buccal podia is_a: ECAO:0104990 ! primary podia associated neuron relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107200 ! appendage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107350 name: spine synonym: "spine appendage" EXACT [] xref: UBERON:0008260 is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000500 ! 8-arm pluteus larva stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107360 name: juvenile spine synonym: "splayed spines" EXACT [] is_a: ECAO:0107350 ! spine relationship: existence_ends_during ECAO:0000560 ! late juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107370 name: definitive spine synonym: "adult spine" EXACT [] is_a: ECAO:0107350 ! spine property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107380 name: sphaeridium is_a: ECAO:0107200 ! appendage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107390 name: ampulla synonym: "tube foot ampulla" EXACT [] xref: UBERON:0008252 is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106980 ! radial canal relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107400 name: adult mouth is_a: ECAO:0105970 ! mouth relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107410 name: adult anus is_a: ECAO:0105990 ! anus relationship: existence_starts_during ECAO:0000560 ! late juvenile stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107418 name: Aristotles lantern xref: UBERON:0008253 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103610 ! digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107420 name: tooth is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107418 ! Aristotles lantern property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107440 name: madreporite xref: UBERON:0009476 is_a: ECAO:0107190 ! genital plate is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107260 ! genital plate CD relationship: existence_starts_during ECAO:0000550 ! early juvenile stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107450 name: gonopore synonym: "genital pore" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0107190 ! genital plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107460 name: gonad xref: UBERON:0000991 is_a: ECAO:0104100 ! adult structure relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107470 name: ovary xref: UBERON:0000992 is_a: ECAO:0107460 ! gonad property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107480 name: testis xref: UBERON:0000473 is_a: ECAO:0107460 ! gonad property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107490 name: juvenile digestive tract is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000560 ! late juvenile stage relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103640 ! juvenile digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107510 name: adult digestive tract is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103630 ! larval digestive system relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0103650 ! adult digestive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107520 name: mesentery xref: UBERON:0002095 is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107530 name: perivisceral cavity is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107540 name: photosensory cell synonym: "photoreceptor cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000550 ! early juvenile stage relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107560 name: embryonic territory def: "A population of embryonic cells that share a common developmental fate or program of gene expression and comprising a region that lacks clear morphological boundaries" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000610 ! open mouth stage relationship: existence_starts_during ECAO:0000190 ! 16-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107570 name: adult organism def: "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage." [] xref: UBERON:0007023 is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103580 ! larva relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107580 name: embryonic muscular system def: "The muscle system of the embryo." [] is_a: ECAO:0103770 ! muscular system relationship: existence_ends_during ECAO:0000610 ! open mouth stage relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107590 name: extracellular matrix def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [] is_a: ECAO:0104270 ! acellular membrane relationship: part_of ECAO:0103550 ! whole organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107600 name: blastomere of 8-cell embryo def: "A blastomere of an 8-cell embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000180 ! 8-cell stage relationship: existence_starts_during ECAO:0000180 ! 8-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107610 name: blastomere of 16-cell embryo def: "A blastomere of a 16-cell embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_ends_during ECAO:0000190 ! 16-cell stage relationship: existence_starts_during ECAO:0000190 ! 16-cell stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107620 name: presumptive animal pole domain neuron def: "A cell that will develop into a neuron of the animal pole domain." [] synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107630 name: presumptive ectoderm neuron def: "An ectodermal cell that will develop into a neuron." [] synonym: "ectoderm neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107640 name: presumptive ciliary band neuron def: "A cell that will develop into a neuron of the ciliary band." [] synonym: "ciliary band neuronal progenitor cell" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107650 name: presumptive endoderm-associated neuron def: "An endodermal cell that will develop into a neuron." [] synonym: " endoderm-ssociated neuronal progenitor cell" EXACT [] synonym: "presumptive endodermal neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107660 name: postoral neuron def: "A neuron located near the base of an oral arm and outside the ciliary band." [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000620 ! early prism stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107670 name: presumptive postoral neuron def: "A cell that will give rise to a postoral neuron." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107680 name: synaptotagmin-B-expressing neuron def: "A neuron that produces the synaptotagmin-B protein." [] synonym: " synaptotagmin-positive neuron" EXACT [] synonym: "synaptotagmin- B neuron" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_ends_during ECAO:0000530 ! adulthood relationship: existence_starts_during ECAO:0000410 ! late gastrula stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107690 name: nitric oxide synthase-expressing neuron def: "A neuron that produces the nitric oxide synthase protein." [] is_a: ECAO:0104790 ! neuron relationship: existence_ends_during ECAO:0000530 ! adulthood relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107700 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [] is_a: ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107710 name: catecholaminergic/cholinergic neuron def: "A neuron that uses both acetylcholine and catecholamines as vesicular neurotransmitters." [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000640 ! early pluteus stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107720 name: endoderm-associated neuron def: "A neuron derived from endoderm." [] synonym: "endodermal neuron" EXACT [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0104780 ! endoderm associated presumptive neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107730 name: lateral ganglion def: "One of two bilateral ganglia that arise in the oral ectoderm near the ciliary band." [] is_a: ECAO:0104930 ! ganglion is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103970 ! animal pole domain relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107740 name: right lateral ganglion def: "The lateral ganglion that forms on the right side of the embryo." [] is_a: ECAO:0107730 ! lateral ganglion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107750 name: left lateral ganglion def: "The lateral ganglion that forms on the left side of the embryo." [] is_a: ECAO:0107730 ! lateral ganglion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107760 name: presumptive ventral ectoderm def: "The part of the blastula that will give rise to ventral ectoderm." [] synonym: "presumptive oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory relationship: existence_ends_during ECAO:0000400 ! mid-gastrula stage relationship: existence_starts_during ECAO:0000230 ! 60-cell stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107770 name: presumptive dorsal ectoderm def: "The part of the blastula that will give rise to dorsal ectoderm." [] synonym: "presumptive aboral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory relationship: existence_ends_during ECAO:0000400 ! mid-gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107780 name: anterior neuroectoderm def: "A dynamic terriritory within the prospective ectoderm of the early embryo, located at the anterior (animal) end of the embryo and shaped by Wnt signaling, that contains cells with neurogenic potential." [] synonym: " ANE" EXACT [] synonym: "animal ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107790 name: equatorial ectoderm def: "A dynamic territory within the prospective ectoderm of the early embryo, located between the anterior neuroectoderm and the endomesoderm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107800 name: inner anterior neuroectoderm def: "The innermost part of the anterior neuroectoderm, immediately surrounding the animal pole." [] synonym: " inner apical pole domain" EXACT [] synonym: "inner ANE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107810 name: outer anterior neuroectoderm def: "A torus shaped region comprising the outer part of the anterior neuroectoderm." [] synonym: " outer apical pole domain" EXACT [] synonym: "outer ANE" EXACT [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105070 ! animal tier 1 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000275 ! stage 10 relationship: part_of ECAO:0103970 ! animal pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107820 name: central ventral ectoderm def: "A region of the ectoderm derived from the animal hemisphere (i.e., mesomere descendants) and located just above the equator on the ventral side of the embryo." [] synonym: "central oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000410 ! late gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107830 name: near apical ectoderm def: "A region of the ectoderm derived from the animal hemisphere (i.e., mesomere descendants) and located between the central ventral ectoderm and the animal pole domain on the ventral side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0105200 ! ventral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107840 name: lateral border ectoderm def: "A region of border ectoderm located on a lateral surface of the embryo." [] synonym: " lateral BE" EXACT [] synonym: "veg1 lateral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107850 name: ventral border ectoderm def: "A region of border ectoderm located on the ventral side of the embryo." [] synonym: " oral BE" EXACT [] synonym: " oral border ectoderm" EXACT [] synonym: " ventral BE" EXACT [] synonym: "veg1 oral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107860 name: dorsal border ectoderm def: "A region of border ectoderm located on the dorsal side of the embryo." [] synonym: " aboral BE" EXACT [] synonym: " aboral border ectoderm" EXACT [] synonym: " dorsal BE" EXACT [] synonym: "veg1 aboral ectoderm" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107870 name: animal lateral ectoderm def: "A region of ectoderm derived from the animal hemisphere and located laterally at the boundary between hte ventral and dorsal ectoderm; this region overlaps with part of the prospective ciliary band." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107880 name: right animal lateral ectoderm def: "The animal lateral ectoderm on the right side of the embryo." [] is_a: ECAO:0105320 ! lateral ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107890 name: left animal lateral ectoderm def: "The animal lateral ectoderm on the left side of the embryo." [] is_a: ECAO:0105320 ! lateral ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103890 ! animal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000690 ! mesenchyme blastula stage relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107900 name: postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0105350 ! arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107910 name: right postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of the right postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0107900 ! postoral arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107920 name: left postoral arm tip ectoderm def: "A portion of the ectoderm located at the tip of the left postoral arm." [] is_a: ECAO:0103530 ! anatomical region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000630 ! late prism stage relationship: part_of ECAO:0107900 ! postoral arm tip ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107930 name: presumptive ciliary band def: "The cells that will give rise to the ciliary band." [] synonym: "presumptive ciliated band" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103730 ! embryonic nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107940 name: arm def: "An elongated extension of the embryo on the ventral side, supported by a simple or fenestrated skeletal rod and often covered in part by a ciliary band. Arms develop in bilaterally symmetrical pairs." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107950 name: anterolateral arm def: "A type of arm that projects from the oral hood; forms after the postoral arms appear and prior to the appearance of the preoral and posterodorsal arms." [] is_a: ECAO:0107940 ! arm relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107960 name: postoral arm def: "A type of arm that forms between the equator and the posterior pole, near the position of the skeletal rudiment; the first type of arm to appear." [] is_a: ECAO:0107940 ! arm relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107970 name: anterolateral rod def: "A rod that forms by the branching or pronounced curving of the anterior tip of a dorsoventral connecting rod and that projects ventrally from the oral hood, supporting an anterolateral arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0107990 ! dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107980 name: postoral rod def: "A rod that forms by the branching of the anonymous rod and projects ventrally, supporting a postoral arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105710 ! anonymous rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0107990 name: dorsoventral connecting rod def: "A rod that initially forms as one of the three arms of the embryonic triradiate spicule rudiment; this rod extends toward the animal pole before branching or curving to form the anterolateral rod and, in some species, the recurrent rod." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108000 name: ventral transverse rod def: "A rod that initially forms as one of the three arms of the embryonic triradiate spicule rudiment; this rod projects toward the ventral midline and ceases growth early in development without branching." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105630 ! spicule granule relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108010 name: distal tip of body rod def: "The growing tip of the body rod as it extends dorsally." [] is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108020 name: distal tip of right body rod def: "The distal tip of the body rod that forms on the right side of the embryo." [] is_a: ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108030 name: distal tip of left body rod def: "The distal tip of the body rod that forms on the left side of the embryo.." [] is_a: ECAO:0105868 ! posterior tip of body rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000620 ! early prism stage relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108040 name: recurrent rod def: "A rod that forms from the branching of a dorsoventral transverse rod and extends dorsally." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0107990 ! dorsoventral connecting rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108050 name: presumptive embryonic skeletogenic mesoderm def: "The part of the embryonic presumptive mesoderm that will later give rise to the skeletogenic mesenchyme and embryonic skeleton." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000600 ! vegetal plate stage relationship: existence_starts_during ECAO:0000210 ! 32-cell stage relationship: part_of ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108060 name: ventrolateral skeletogenic mesenchyme cluster def: "A cluster of skeletogenic cell bodies that forms in the ventrolateral region of the subequatorial skeletogenic mesenchyme ring; one triradiate spicule rudiment will form in each of two ventrolateral clusters." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108070 name: presumptive embryonic non-skeletogenic mesoderm def: "Embryonic cells tin the epithelial wall of the vegetal plate or the archenteron that will give rise to mesodermal derivatives other than skeleton." [] synonym: "NSM" EXACT [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000620 ! early prism stage relationship: existence_starts_during ECAO:0000280 ! late blastula stage relationship: part_of ECAO:0106200 ! presumptive mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108080 name: ventral presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm on the ventral side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108090 name: dorsal presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm on the dorsal side of the embryo." [] is_a: ECAO:0107560 ! embryonic territory is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103900 ! vegetal hemisphere relationship: existence_ends_during ECAO:0000390 ! early gastrula stage relationship: existence_starts_during ECAO:0000600 ! vegetal plate stage relationship: part_of ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108100 name: presumptive muscle cell def: "A cell that will give rise to a muscle cell." [] synonym: "muscle precursor cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104020 ! vegetal plate relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0103770 ! muscular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108110 name: muscle cell def: "A cell that is part of a muscle." [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0108100 ! presumptive muscle cell relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106550 ! muscle property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108120 name: presumptive blastocoel def: "The inner, extracellular space between blastomeres of the cleavage stage embryo that will gradually expand and form the blastocoel." [] is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000230 ! 60-cell stage relationship: existence_starts_during ECAO:0000200 ! 28-cell stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108130 name: pyloric sphincter muscle cell def: "A cell that is part of the pyloric sphincter." [] is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000610 ! open mouth stage relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108140 name: cardiac sphincter muscle cell def: "A cell that is part of the cardiac sphincter." [] is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108150 name: anal sphincter muscle cell def: "A cell that is part of the anal sphincter." [] synonym: "anal pore muscle cell" EXACT [] xref: UBERON:0004916 is_a: ECAO:0106660 ! sphincter muscle cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000640 ! early pluteus stage relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108160 name: primary pore canal rudiment def: "A strand of mesenchyme cells that extends from the left coelom to the ectoderm and that will give rise to the primary pore canal." [] synonym: "presumptive hydropore canal" EXACT [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106800 ! left coelomic pouch relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103870 ! water vascular system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108170 name: posterior enterocoel def: "An evagination of the midgut that will contribute to the coelom." [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0106070 ! midgut relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108180 name: left anterior coelomic pouch def: "In species with a posterior enterocoel, the left coelomic pouch that evaginates from the unpaired coelomic pouch at the anterior end of the archenteron." [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108190 name: right anterior coelomic pouch def: "In species with a posterior enterocoel, the right coelomic pouch that evaginates from the unpaired coelomic pouch at the anterior end of the archenteron." [] is_a: ECAO:0106770 ! coelom relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108200 name: preoral ciliary band def: "In species with two separate ciliary bands, a ciliary band that surrounds the anterior-ventral end of the embryo, anterior to the mouth." [] is_a: ECAO:0105460 ! ciliary band is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107930 ! presumptive ciliary band relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0108210 name: postoral ciliary band def: "In species with two separate ciliary bands, a ciliary band that surrounds the posterior-dorsal end of the embryo, posterior to the mouth." [] is_a: ECAO:0105460 ! ciliary band is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0107930 ! presumptive ciliary band relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109000 name: anatomical element def: "An anatomical structure that is a subdivision of a tissue, a germ layer, or an organ of the whole organism but with well-defined morphological boundaries." [] synonym: "anatomical object" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109010 name: zygote def: "A diploid cell produced by the fusion of a male and a female gamete at fertilization. It constitutes the first stage of the embryogenesis life cycle phase." [] synonym: " 1-cell" EXACT [] synonym: "fertilized egg" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000135 ! stage 1 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109020 name: cleavage embryo def: "A multicellular organism at an early stage of development characterized by cleavage. It includes all forms of the cleavage period during the embryogenesis life cycle phase (i.e., from first cleavage to before the formation of the blastula)." [] synonym: "cleaving embryo" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109010 ! zygote relationship: existence_ends_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109030 name: blastula def: "A multicellular organism at an early stage of development corresponding to a hollow, spherical, multicellular, monolayered embryo with a hollow cavity (the blastocoel) in the center. It includes all forms of the blastula period during the embryogenesis life cycle phase." [] synonym: "morula" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109020 ! cleavage embryo relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109040 name: gastrula def: "A multicellular organism at an early stage of development characterized by morphogenetic movements. It includes all forms of the gastrula period during the embryogenesis life cycle phase." [] synonym: "gastrulating embryo" EXACT [] is_a: ECAO:0103570 ! embryo is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109030 ! blastula relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109050 name: pre-metamorphic organism def: "A multicellular organism the existence of which starts at fertilization and ends with metamorphosis. It includes all forms during the embryogenesis and larval development life cycle phases." [] synonym: "pre-metamorphosing organism" EXACT [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109010 ! zygote relationship: existence_ends_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109060 name: post-embryonic organism def: "A multicellular organism the existence of which starts upon the opening of the mouth and ends with death. It includes all forms during the larval development and adulthood life cycle phases." [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103570 ! embryo relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109070 name: mature adult def: "A multicellular organism the existence of which starts with gamete production and ends with death." [] synonym: " post-juvenile adult" EXACT [] synonym: "sexually mature adult" EXACT [] is_a: ECAO:0103560 ! multicellular organism is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0103590 ! juvenile relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109080 name: embryonic region def: "A portion of an embryo (or a population of embryonic cells) that is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "embryonic territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109090 name: larval region def: "A portion of a larva (or a population of larval cells) that is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "larval territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109100 name: pre-metamorphic organism region def: "A population of cells that, throughout the embryogenesis and larval development life cycle phases, is characterized by a common developmental fate or a common gene expression program but lacks any clear morphological boundaries." [] synonym: "pre-metamorphic territory" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109110 name: organ def: "A multicellular anatomical structure made of several tissues, performing a specific function or group of functions." [] is_a: ECAO:0109000 ! anatomical element relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103520 ! anatomical system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109120 name: pre-metamorphic organism tissue def: "A tissue that is present in a pre-metamorphic organism." [] is_a: ECAO:0104110 ! tissue relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109130 name: pre-metamorphic organism structure def: "An anatomical structure that is part of a pre-metamorphic organism." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109140 name: pre-metamorphic organism immune system def: "The immune system of a pre-metamorphic organism." [] is_a: ECAO:0103660 ! immune system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109150 name: female reproductive system def: "An anatomical reproductive system that is present in a female multicellular organism." [] is_a: ECAO:0103710 ! reproductive system relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109160 name: male reproductive system def: "An anatomical reproductive system that is present in a male multicellular organism." [] is_a: ECAO:0103710 ! reproductive system relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109170 name: pre-metamorphic organism nervous system def: "The neurons and glial cells constituting the nervous system of a pre-metamorphic organism." [] is_a: ECAO:0103720 ! nervous system relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109180 name: pre-metamorphic organism endoskeleton def: "The endoskeleton of a pre-metamorphic organism." [] synonym: "pre-metamorphic organism skeleton" EXACT [] is_a: ECAO:0103810 ! endoskeleton relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109190 name: skeletal tissue def: "A specialized form of connective tissue in which the extracellular matrix is mineralized and that functions in mechanical and structural support." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000395 ! stage 14 relationship: part_of ECAO:0103810 ! endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109200 name: embryonic hemisphere def: "One of two hemispheres of an embryo." [] synonym: "hemisphere of embryo" EXACT [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109210 name: animal cell tier def: "A cell tier present in the animal hemisphere of an embryo." [] synonym: "animal blastomere tier" EXACT [] is_a: ECAO:0104678 ! cell tier relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109220 name: vegetal cell tier def: "A cell tier present in the vegetal hemisphere of an embryo." [] synonym: "vegetal blastomere tier" EXACT [] is_a: ECAO:0104678 ! cell tier relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109230 name: cell body def: "The portion of a cell bearing surface projections such as axons, filopodia, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109240 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [] synonym: " germline cell" EXACT [] synonym: "germ line stem cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000195 ! stage 6 relationship: part_of ECAO:0103710 ! reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109250 name: female germ cell def: "A germ cell that supports female gamete production." [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109260 name: male germ cell def: "A germ cell that supports male gamete production." [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109270 name: mature germ cell def: "The reproductive haploid, mature sexual reproductive cell of a multicellular organism." [] synonym: "gamete" EXACT [] is_a: ECAO:0104570 ! germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109280 name: primary oocyte def: "An immature oocyte that is diploid and has not completed female meiosis I." [] is_a: ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109290 name: secondary oocyte def: "An immature oocyte that is haploid but has not completed female meiosis II." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109280 ! primary oocyte relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109150 ! female reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109300 name: spermatogonium def: "An euploid male germ cell of an early stage of spermatogenesis. It is morphologically unlike spermatocytes and spermatids." [] is_a: ECAO:0104560 ! primordial germ cell relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109310 name: spermatocyte def: "A male germ cell that develops from spermatogonia." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109300 ! spermatogonium relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109320 name: spermatid def: "A male germ cell that develops from spermatocytes." [] is_a: ECAO:0104560 ! primordial germ cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109310 ! spermatocyte relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0109160 ! male reproductive system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109330 name: spermatozoid nucleus def: "An intracellular anatomical structure in which the male chromosomes are housed." [] synonym: " male germ cell nucleus" EXACT [] synonym: "sperm nucleus" EXACT [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104247 ! spermatozoid property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109340 name: oocyte nucleus def: "An intracellular anatomical structure in which the female chromosomes are housed." [] synonym: " female germ cell nucleus" EXACT [] synonym: "female nucleus" EXACT [] is_a: ECAO:0104160 ! nucleus relationship: existence_starts_during ECAO:0000580 ! adult stage relationship: part_of ECAO:0104168 ! oocyte property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109350 name: cellular anatomical entity def: "Any constituent part of a cell that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical structure." [] synonym: "cell part" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: part_of ECAO:0104030 ! cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109360 name: intracellular anatomical structure def: "A component of a cell contained within (but not including) the plasma membrane. It includes as examples the nucleus, mitochondria, vesicles, and the cytoskeleton." [] synonym: " organelle" EXACT [] synonym: "intracellular part" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109370 name: cell-cell junction def: "A cell junction that forms a connection between two or more cells of a multicellular organism." [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000165 ! stage 3 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109380 name: desmosome def: "A strong cell-cell junction usually found in tissue that experience intense mechanical stress." [] synonym: "spot desmosome" EXACT [] is_a: ECAO:0109370 ! cell-cell junction property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109390 name: septate junction def: "A cell-cell junction that forms a continuous band around each cell in an epithelium." [] synonym: "spetate desmosome" EXACT [] is_a: ECAO:0109370 ! cell-cell junction property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109400 name: adherens junction def: "A cell-cell junction composed of the epithelial cadherin-catenin complex." [] is_a: ECAO:0109370 ! cell-cell junction relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109410 name: microtubule cytoskeleton def: "The part of the cytoskeleton composed of microtubules and associated proteins." [] is_a: ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109420 name: filament def: "A component of a cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [] synonym: " fiber" EXACT [] synonym: " polymeric cytoskeletal fiber" EXACT [] synonym: "protein filament" EXACT [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104148 ! cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109430 name: spindle pole def: "The either end of a spindle, from where the spindle microtubules emanate." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0109410 ! microtubule cytoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109440 name: equator region def: "The middle region of an oocyte or a zygote, which comprises the most basal portion of the animal and vegetal hemispheres." [] synonym: "equator" EXACT [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109450 name: kinetochore def: "A multisubunit complex that is located on chromosomes and provides an attachment point for the spindle microtubules." [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: part_of ECAO:0109510 ! chromosome property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109460 name: apical cilium def: "A cilium that develops on the apical surface of a cell." [] is_a: ECAO:0104340 ! cilium relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109470 name: short motile cilium def: "A cilium of short size exhibiting motility thanks to the molecular motors it contains. In echinoderms, short motile cilia are encountered on the outer surface of the developing embryo as well as in the developing and developed digestive tract of embryos and larvae." [] is_a: ECAO:0104340 ! cilium relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109480 name: long immotile cilium def: "A cilium of long size that does not contain molecular motors and as such does not exhibit any beating movement. In some echinoderms, long immotile cilia are found, when present, at the animal pole of embryos and constitute the apical tuft." [] synonym: " elongated cilium" EXACT [] synonym: "long non-motile cilium" EXACT [] is_a: ECAO:0104340 ! cilium relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0105380 ! apical tuft property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109490 name: filopodial cable def: "A sheet-like cellular projection that is supported by an ordered network of actin filaments and that is involved in cellular motility and syncytium formation." [] synonym: "lamellipodia" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109500 name: nucleolus def: "A small, dense body present in the nucleus of cells and that is rich in RNA and protein, not bounded by a limiting membrane, and not seen during mitosis." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109510 name: chromosome def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [] is_a: ECAO:0109360 ! intracellular anatomical structure relationship: part_of ECAO:0104160 ! nucleus property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109520 name: animal blastomere def: "An undifferentiated cell part of the animal hemisphere of an embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_starts_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103890 ! animal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109530 name: vegetal blastomere def: "An undifferentiated cell part of the vegetal hemisphere of an embryo." [] is_a: ECAO:0104630 ! blastomere relationship: existence_starts_during ECAO:0000175 ! stage 4 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109540 name: macromere descendant cell def: "A cell derived from a macromere through cell division." [] is_a: ECAO:0104010 ! embryonic cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104670 ! macromere relationship: existence_ends_during ECAO:0000284 ! stage 11 relationship: existence_starts_during ECAO:0000215 ! stage 7 relationship: part_of ECAO:0103900 ! vegetal hemisphere property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109550 name: presumptive blastocoel def: "The inner, extracellular space between blastomeres of the cleavage stage embryos that will gradually expand and form the blastocoel." [] is_a: ECAO:0103540 ! anatomical space relationship: existence_ends_during ECAO:0000230 ! 60-cell stage relationship: existence_starts_during ECAO:0000200 ! 28-cell stage relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109560 name: blastocoel roof def: "The most apical region of the blastocoel." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0106600 ! blastocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109570 name: blastocoel wall def: "The region of the blastocoel comprised in the middle region of the embryo, below the blastocoel roof." [] is_a: ECAO:0109080 ! embryonic region relationship: part_of ECAO:0106600 ! blastocoel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109580 name: ectoderm cell def: "A cell part of the ectoderm germ layer." [] synonym: "ectodermal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109590 name: epidermis def: "An epithelium derived from ectoderm and constituting the outermost protective layer of an embryo, a larva, or an adult." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109600 name: epithelium def: "A tissue that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109610 name: embryonic ectoderm def: "The ectoderm that is specifically present in an embryo" [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109620 name: larval ectoderm def: "The ectoderm that is specifically present in a larva." [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0109610 ! embryonic ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109630 name: pre-metamorphic organism ectoderm def: "The ectoderm that is specifically present in an embryo and a larva but not in an adult." [] is_a: ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109640 name: vegetal tier 1 ectoderm def: "The ectoderm that specifically derives from cells of the veg1 tier." [] synonym: " veg1 ectoderm" EXACT [] synonym: "veg1 ecto" EXACT [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_starts_during ECAO:0000265 ! stage 9 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109650 name: non-apical ectoderm def: "The ectoderm that is part of the animal ectoderm but located below the apical pole domain ectoderm." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0105180 ! animal ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109660 name: apical pole domain def: "A thickened region at the animal hemisphere, located at the animal pole, and that contains developing neurons and cells with elongated cilia." [] synonym: " animal plate" EXACT [] synonym: " apical plate" EXACT [] synonym: "animal pole domain" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109670 name: apical pole domain ectoderm def: "The ectoderm that is part of the animal ectoderm and is specifically restricted to the apical pole domain." [] synonym: "apical ectoderm" EXACT [] is_a: ECAO:0105180 ! animal ectoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000255 ! stage 8 relationship: part_of ECAO:0109660 ! apical pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109680 name: presumptive oral ectoderm def: "The portion of the presumptive ectoderm that is located on the oral side of the embryo (which will later generate the ventral side of the larva)." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109690 name: oral ectoderm def: "The portion of the embryonic ectoderm that is located on the oral side of the embryo and will give rise to ventral ectoderm of the larva." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0109680 ! presumptive oral ectoderm relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109700 name: presumptive aboral ectoderm def: "The portion of the presumptive ectoderm that is located on the aboral side of the embryo (which will later generate the dorsal side of the larva)." [] synonym: "lateral-aboral pre-state ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105160 ! presumptive ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109710 name: aboral ectoderm def: "The portion of the embryonic ectoderm that is located on the aboral side of the embryo and will give rise to dorsal ectoderm of the larva." [] is_a: ECAO:0105160 ! presumptive ectoderm relationship: develops_from ECAO:0109700 ! presumptive aboral ectoderm relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109720 name: oral border ectoderm def: "The portion of the border ectoderm that is located on the oral side of the embryo." [] synonym: " equatorial oral ectoderm" EXACT [] synonym: " oral BE" EXACT [] synonym: " ventral BE" EXACT [] synonym: "veg1 oral ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109730 name: aboral border ectoderm def: "The portion of the border ectoderm that is located on the aboral side of the embryo." [] synonym: " aboral BE" EXACT [] synonym: " dorsal BE" EXACT [] synonym: "veg1 aboral ectoderm" EXACT [] is_a: ECAO:0109080 ! embryonic region is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0105270 ! border ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109740 name: stomodeal presumptive ectoderm def: "The portion of the presumptive oral ectoderm where the stomodeum will form." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0109680 ! presumptive oral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109750 name: stomodeal ectoderm def: "The portion of the oral ectoderm where the stomodeum forms." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0109690 ! oral ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109760 name: neuroectoderm def: "The portion of the ectoderm where neurons form." [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000260 ! early blastula stage relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109770 name: presumptive apical pole domain neuron def: "An ectodermal progenitor cell from the animal pole domain that will develop into a neuron." [] synonym: " animal pole domain neuronal progenitor cell" EXACT [] synonym: "apical pole domain presumptive neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0109660 ! apical pole domain property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109780 name: presumptive endoderm neuron def: "An endodermal cell that will develop into a neuron." [] synonym: " endoderm-ssociated neuronal progenitor cell" EXACT [] synonym: "presumptive endodermal neuron" EXACT [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109790 name: presumptive postoral arm neuron def: "A neuronal progenitor cell present in the epidermis of a postoral arm." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0110400 ! postoral arm ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109800 name: presumptive oral hood neuron def: "A neuronal progenitor cell present in the epidermis of the oral hood." [] is_a: ECAO:0104740 ! presumptive neuron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0105520 ! oral hood property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109810 name: postoral arm neuron def: "A neuron that is located in the postoral arm ectoderm outside the ciliary band." [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0109790 ! presumptive postoral arm neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109820 name: oral hood neuron def: "A neuron that is located in the oral hood." [] is_a: ECAO:0104800 ! larval neuron relationship: develops_from ECAO:0109800 ! presumptive oral hood neuron relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105520 ! oral hood property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109830 name: nitric oxide synthase neuron def: "A neuron of which transmission is mediated by nitric oxide." [] synonym: "nitrergic neuron" EXACT [] is_a: ECAO:0104790 ! neuron relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109840 name: axon def: "The long process of a neuron that conducts nerve impulses, usually away from the neural cell body." [] synonym: "nerve fiber" EXACT [] is_a: ECAO:0109350 ! cellular anatomical entity relationship: existence_starts_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109850 name: neural cell body def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons." [] synonym: "neuonal cell body" EXACT [] is_a: ECAO:0109230 ! cell body relationship: part_of ECAO:0104790 ! neuron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109860 name: apical organ def: "A neural structure that develops from the apical pole domain, above the mouth, and contains neurons." [] is_a: ECAO:0104878 ! neural structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103740 ! larval nervous system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109870 name: presumptive oral ciliary band def: "A specific embryonic or larval ectodermal territory located on the oral side and that will give rise to the oral hood ciliary band." [] synonym: "pre-oral ciliary band" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: part_of ECAO:0104908 ! ectoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109880 name: ciliary band cell def: "A cell that composes the ciliary band." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0105460 ! ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109890 name: oral hood ciliary band cell def: "A cell that composes the oral hood ciliary band." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105470 ! oral hood ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109900 name: arm bud ciliary band def: "The portion of the ciliary band that covers the arm buds." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109910 name: arm distal tip ciliary band def: "The portion of the arm ciliary band that covers the arm distal tip." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109920 name: arm proximal tip ciliary band def: "The portion of the arm ciliary band that covers the arm proximal tip." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109930 name: arm middle portion ciliary band def: "The portion of the arm ciliary band that covers the region of the arm between the distal and proximal tips." [] is_a: ECAO:0105480 ! arm ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109940 name: animal presumptive ciliary band def: "The portion of the presumptive ciliary band that overlaps with the animal pole domain." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109950 name: vegetal presumtive ciliary band def: "The portion of the presumptive ciliary band located close to the vegetal pole." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109960 name: lateral presumptive ciliary band def: "The portion of the presumptive ciliary located between the animal and the vegetal presumptive ciliary bands." [] is_a: ECAO:0107930 ! presumptive ciliary band property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109970 name: preoral presumptive ciliary band def: "In species with two separate ciliary bands, a specific embryonic territory that will develop into the preoral ciliary band." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109980 name: postoral presumptive ciliary band def: "In species with two separate ciliary bands, a specific embryonic territory that will develop into the postoral ciliary band." [] is_a: ECAO:0107930 ! presumptive ciliary band relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0109990 name: pre-oral hood def: "A specific ectodermal territory located on the oral side of the embryo or the larva and that will give rise to the oral hood." [] synonym: " preoral lobe" EXACT [] synonym: "preoral hood" EXACT [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110000 name: arm bud def: "An embryonic region that will develop into an arm." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110010 name: arm distal tip def: "The distal extremity of a larval arm, i.e. the further away from the larval body" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110020 name: arm proximal tip def: "The proximal extremity of a larval arm, i.e. the closest to the larval body" [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110030 name: arm middle portion def: "The portion of a larval arm comprised between the distal and proximal tips of the arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110040 name: arm bud ectoderm def: "The thickened ectodermal region that outlines the arm bud." [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110000 ! arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110050 name: arm ectoderm def: "The ectodermal (or epidermal) portion of the arm skin and that does not include the ciliary band." [] synonym: "arm epidermis" EXACT [] is_a: ECAO:0104908 ! ectoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0110040 ! arm bud ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110060 name: arm distal tip ectoderm def: "The ectodermal (or epidermal) that covers the distal arm tip and does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110010 ! arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110070 name: arm proximal tip ectoderm def: "The ectodermal (or epidermal) that covers the proximal arm tip and does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110020 ! arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110080 name: arm middle portion ectoderm def: "The ectodermal (or epidermal) that covers the portion of the arm located between the distal and proximal tips and that does not include the ciliary band." [] is_a: ECAO:0110050 ! arm ectoderm relationship: part_of ECAO:0110030 ! arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110090 name: arm bud skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell present in the arm bud and that will contribute to the development of a skeletal rod." [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110000 ! arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110100 name: skeletal rod distal tip def: "The distal tip of a skeletal rod, i.e. the further away from its initiation site." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110110 name: skeletal rod proximal tip def: "The proximal tip of a skeletal rod, i.e. the closest to its initiation site." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110120 name: skeletal rod middle portion def: "The portion of a skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110130 name: arm skeletal rod def: "A skeletal rod supporting an arm." [] is_a: ECAO:0105700 ! skeletal rod relationship: develops_from ECAO:0105700 ! skeletal rod relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107940 ! arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110140 name: arm skeletal rod distal tip def: "The distal tip of an arm skeletal rod, i.e. the further away from its initiation site and the larval body." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110150 name: arm skeletal rod proximal tip def: "The proximal tip of an arm skeletal rod, i.e. the closest to its initiation site and the larval body." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110160 name: arm skeletal rod middle portion def: "The portion of an arm skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110170 name: skeletal rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a skeletal rod." [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0105700 ! skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110180 name: skeletal rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a skeletal rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0110100 ! skeletal rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110190 name: skeletal rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a skeletal rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0110110 ! skeletal rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110200 name: skeletal rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the region of a skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110120 ! skeletal rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110210 name: arm skeletal rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an arm skeletal rod." [] synonym: "arm skeletogenic mesenchyme cell" EXACT [] is_a: ECAO:0112340 ! skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0110130 ! arm skeletal rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110220 name: arm skeletal rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an arm skeletal rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000610 ! open mouth stage relationship: part_of ECAO:0110140 ! arm skeletal rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110230 name: arm skeletal rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an arm skeletal rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000610 ! open mouth stage relationship: part_of ECAO:0110150 ! arm skeletal rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110240 name: arm skeletal rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the region of an arm skeletal rod comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: part_of ECAO:0110160 ! arm skeletal rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110250 name: postoral arm bud def: "An arm bud that will develop into a postoral arm." [] is_a: ECAO:0110000 ! arm bud is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105270 ! border ectoderm relationship: existence_ends_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110260 name: right postoral arm bud def: "The arm bud on the right side of the embryo that will develop into a postoral arm." [] is_a: ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110270 name: left postoral arm bud def: "The arm bud on the left side of the embryo that will develop into a postoral arm." [] is_a: ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110280 name: postoral arm distal tip def: "The distal tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110290 name: right postoral arm distal tip def: "The distal tip of a right postoral arm." [] is_a: ECAO:0110280 ! postoral arm distal tip relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110300 name: left postoral arm distal tip def: "The distal tip of a left postoral arm." [] is_a: ECAO:0110280 ! postoral arm distal tip relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110310 name: postoral arm proximal tip def: "The proximal tip of a postoral arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110320 name: right postoral arm proximal tip def: "The proximal tip of a right postoral arm." [] is_a: ECAO:0110310 ! postoral arm proximal tip relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110330 name: left postoral arm proximal tip def: "The proximal tip of a left postoral arm." [] is_a: ECAO:0110310 ! postoral arm proximal tip relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110340 name: postoral arm middle portion def: "The middle region of a postoral arm comprised between the distal and proximal tip of the arm." [] is_a: ECAO:0103530 ! anatomical region relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110350 name: right postoral arm middle portion def: "The middle region of a right postoral arm." [] is_a: ECAO:0110340 ! postoral arm middle portion relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110360 name: left postoral arm middle portion def: "The middle region of a left postoral arm." [] is_a: ECAO:0110340 ! postoral arm middle portion relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110370 name: postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud." [] is_a: ECAO:0110040 ! arm bud ectoderm relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0110250 ! postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110380 name: right postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud on the right side of the embryo." [] is_a: ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0110260 ! right postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110390 name: left postoral arm bud ectoderm def: "The portion of the ectoderm that outlines a postoral arm bud on the left side of the embryo." [] is_a: ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0110270 ! left postoral arm bud property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110400 name: postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a postoral arm but does not include the ciliary band." [] synonym: "postoral ectoderm" EXACT [] is_a: ECAO:0110050 ! arm ectoderm relationship: develops_from ECAO:0110370 ! postoral arm bud ectoderm relationship: part_of ECAO:0107960 ! postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110410 name: right postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a right postoral arm but does not include the ciliary band." [] synonym: "right postoral ectoderm" EXACT [] is_a: ECAO:0110400 ! postoral arm ectoderm relationship: develops_from ECAO:0110380 ! right postoral arm bud ectoderm relationship: part_of ECAO:0105570 ! right postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110420 name: left postoral arm ectoderm def: "The ectoderm (or epidermis) that covers a left postoral arm but does not include the ciliary band." [] synonym: "left postoral ectoderm" EXACT [] is_a: ECAO:0110400 ! postoral arm ectoderm relationship: develops_from ECAO:0110390 ! left postoral arm bud ectoderm relationship: part_of ECAO:0105580 ! left postoral arm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110430 name: postoral arm distal tip ectoderm def: "The portion of a postoral arm ectoderm located at the distal tip of the arm." [] is_a: ECAO:0110060 ! arm distal tip ectoderm relationship: part_of ECAO:0110280 ! postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110440 name: right postoral arm distal tip ectoderm def: "The postoral arm distal tip ectoderm part of a right postoral arm." [] is_a: ECAO:0110430 ! postoral arm distal tip ectoderm relationship: part_of ECAO:0110290 ! right postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110450 name: left postoral arm distal tip ectoderm def: "The postoral arm distal tip ectoderm part of a left postoral arm." [] is_a: ECAO:0110430 ! postoral arm distal tip ectoderm relationship: part_of ECAO:0110300 ! left postoral arm distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110460 name: postoral arm proximal tip ectoderm def: "The portion of a postoral arm ectoderm located at the proximal tip of the arm." [] is_a: ECAO:0110070 ! arm proximal tip ectoderm relationship: part_of ECAO:0110310 ! postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110470 name: right postoral arm proximal tip ectoderm def: "The postoral arm proximal tip ectoderm part of a right postoral arm." [] is_a: ECAO:0110460 ! postoral arm proximal tip ectoderm relationship: part_of ECAO:0110320 ! right postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110480 name: left postoral arm proximal tip ectoderm def: "The postoral arm proximal tip ectoderm part of a left postoral arm." [] is_a: ECAO:0110460 ! postoral arm proximal tip ectoderm relationship: part_of ECAO:0110330 ! left postoral arm proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110490 name: postoral arm middle portion ectoderm def: "The portion of a postoral arm ectoderm located between the distal and proximal tips of the arm." [] is_a: ECAO:0110080 ! arm middle portion ectoderm relationship: part_of ECAO:0110340 ! postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110500 name: right postoral arm middle portion ectoderm def: "The postoral arm middle portion ectoderm part of a right postoral arm." [] is_a: ECAO:0110490 ! postoral arm middle portion ectoderm relationship: part_of ECAO:0110350 ! right postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110510 name: left postoral arm middle portion ectoderm def: "The postoral arm middle portion ectoderm part of a left postoral arm." [] is_a: ECAO:0110490 ! postoral arm middle portion ectoderm relationship: part_of ECAO:0110360 ! left postoral arm middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110520 name: postoral rod distal tip def: "The distal tip of a postoral rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110530 name: right postoral rod distal tip def: "The distal tip of a right postoral rod." [] is_a: ECAO:0110520 ! postoral rod distal tip relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110540 name: left postoral rod distal tip def: "The distal tip of a left postoral rod." [] is_a: ECAO:0110520 ! postoral rod distal tip relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110550 name: postoral rod proximal tip def: "The proximal tip of a postoral rod." [] is_a: ECAO:0110150 ! arm skeletal rod proximal tip relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110560 name: right postoral rod proximal tip def: "The proximal tip of a right postoral rod." [] is_a: ECAO:0110550 ! postoral rod proximal tip relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110570 name: left postoral rod proximal tip def: "The proximal tip of a left postoral rod." [] is_a: ECAO:0110550 ! postoral rod proximal tip relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110580 name: postoral rod middle portion def: "The middle region of a postoral rod comprised between the distal and proximal tip of the rod." [] is_a: ECAO:0110160 ! arm skeletal rod middle portion relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110590 name: right postoral rod middle portion def: "The middle region of a right postoral rod." [] is_a: ECAO:0110580 ! postoral rod middle portion relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110600 name: left postoral rod middle portion def: "The middle region of a left postoral rod." [] is_a: ECAO:0110580 ! postoral rod middle portion relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110610 name: postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a postoral rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0107980 ! postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110620 name: right postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right postoral rod." [] is_a: ECAO:0110610 ! postoral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105760 ! right postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110630 name: left postoral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left postoral rod." [] is_a: ECAO:0110610 ! postoral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105770 ! left postoral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110640 name: postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a postoral rod." [] is_a: ECAO:0110220 ! arm skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110520 ! postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110650 name: right postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right postoral rod." [] is_a: ECAO:0110640 ! postoral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110530 ! right postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110660 name: left postoral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left postoral rod." [] is_a: ECAO:0110640 ! postoral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110540 ! left postoral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110670 name: postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a postoral rod." [] is_a: ECAO:0110230 ! arm skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110550 ! postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110680 name: right postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right postoral rod." [] is_a: ECAO:0110670 ! postoral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110560 ! right postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110690 name: left postoral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left postoral rod." [] is_a: ECAO:0110670 ! postoral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110570 ! left postoral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110700 name: postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a postoral rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110240 ! arm skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0110580 ! postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110710 name: right postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right postoral rod." [] is_a: ECAO:0110700 ! postoral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110590 ! right postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110720 name: left postoral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left postoral rod." [] is_a: ECAO:0110700 ! postoral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110600 ! left postoral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110730 name: anonymous rod distal tip def: "The distal tip of an anonymous rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110740 name: right anonymous rod distal tip def: "The distal tip of a right anonymous rod." [] is_a: ECAO:0110730 ! anonymous rod distal tip relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110750 name: left anonymous rod distal tip def: "The distal tip of a left anonymous rod." [] is_a: ECAO:0110730 ! anonymous rod distal tip relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110760 name: anonymous rod proximal tip def: "The proximal tip of an anonymous rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110770 name: right anonymous rod proximal tip def: "The proximal tip of a right anonymous rod." [] is_a: ECAO:0110760 ! anonymous rod proximal tip relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110780 name: left anonymous rod proximal tip def: "The proximal tip of a left anonymous rod." [] is_a: ECAO:0110760 ! anonymous rod proximal tip relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110790 name: anonymous rod middle portion def: "The middle region of an anonymous rod comprised between the distal and proximal tip of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110800 name: right anonymous rod middle portion def: "The middle region of a right anonymous rod." [] is_a: ECAO:0110790 ! anonymous rod middle portion relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110810 name: left anonymous rod middle portion def: "The middle region of a left anonymous rod." [] is_a: ECAO:0110790 ! anonymous rod middle portion relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110820 name: anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0105710 ! anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110830 name: right anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right anonymous rod." [] is_a: ECAO:0110820 ! anonymous rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105720 ! right anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110840 name: left anonymous rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left anonymous rod." [] is_a: ECAO:0110820 ! anonymous rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105730 ! left anonymous rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110850 name: anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0110730 ! anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110860 name: right anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right anonymous rod." [] is_a: ECAO:0110850 ! anonymous rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110740 ! right anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110870 name: left anonymous rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left anonymous rod." [] is_a: ECAO:0110850 ! anonymous rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110750 ! left anonymous rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110880 name: anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an anonymous rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0110760 ! anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110890 name: right anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right anonymous rod." [] is_a: ECAO:0110880 ! anonymous rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110770 ! right anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110900 name: left anonymous rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left anonymous rod." [] is_a: ECAO:0110880 ! anonymous rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110780 ! left anonymous rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110910 name: anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of an anonymous rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0110790 ! anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110920 name: right anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right anonymous rod." [] is_a: ECAO:0110910 ! anonymous rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110800 ! right anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110930 name: left anonymous rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left anonymous rod." [] is_a: ECAO:0110910 ! anonymous rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0110810 ! left anonymous rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110940 name: anterolateral rod distal tip def: "The distal tip of an anterolateral rod, i.e. away from its connection with the dorsoventral connecting rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110950 name: right anterolateral rod distal tip def: "The distal tip of a right anterolateral rod." [] is_a: ECAO:0110940 ! anterolateral rod distal tip relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110960 name: left anterolateral rod distal tip def: "The distal tip of a left anterolateral rod." [] is_a: ECAO:0110940 ! anterolateral rod distal tip relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110970 name: anterolateral rod proximal tip def: "The proximal tip of an anterolateral rod, i.e. in connection with the dorsoventral connecting rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110980 name: right anterolateral rod proximal tip def: "The proximal tip of a right anterolateral rod." [] is_a: ECAO:0110970 ! anterolateral rod proximal tip relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0110990 name: left anterolateral rod proximal tip def: "The proximal tip of a left anterolateral rod." [] is_a: ECAO:0110970 ! anterolateral rod proximal tip relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111000 name: anterolateral rod middle portion def: "The middle portion of an anterolateral rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110140 ! arm skeletal rod distal tip relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111010 name: right anterolateral rod middle portion def: "The middle portion of a right anterolateral rod." [] is_a: ECAO:0111000 ! anterolateral rod middle portion relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111020 name: left anterolateral rod middle portion def: "The middle portion of a left anterolateral rod." [] is_a: ECAO:0111000 ! anterolateral rod middle portion relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111030 name: anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of an anterolateral rod." [] is_a: ECAO:0110210 ! arm skeletal rod skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0107970 ! anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111040 name: right anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right anterolateral rod." [] is_a: ECAO:0111030 ! anterolateral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105740 ! right anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111050 name: left anterolateral rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left anterolateral rod." [] is_a: ECAO:0111030 ! anterolateral rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105750 ! left anterolateral rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111060 name: anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of an anterolateral rod." [] is_a: ECAO:0110220 ! arm skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110940 ! anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111070 name: right anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right anterolateral rod." [] is_a: ECAO:0111060 ! anterolateral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110950 ! right anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111080 name: left anterolateral rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left anterolateral rod." [] is_a: ECAO:0111060 ! anterolateral rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110960 ! left anterolateral rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111090 name: anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of an anterolateral rod." [] is_a: ECAO:0110230 ! arm skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0110970 ! anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111100 name: right anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right anterolateral rod." [] is_a: ECAO:0111090 ! anterolateral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110980 ! right anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111110 name: left anterolateral rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left anterolateral rod." [] is_a: ECAO:0111090 ! anterolateral rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0110990 ! left anterolateral rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111120 name: anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of an anterolateral rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110240 ! arm skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111000 ! anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111130 name: right anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right anterolateral rod." [] is_a: ECAO:0111120 ! anterolateral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111010 ! right anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111140 name: left anterolateral rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left anterolateral rod." [] is_a: ECAO:0111120 ! anterolateral rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111020 ! left anterolateral rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111150 name: dorsoventral connecting rod animal tip def: "The portion of a dorsoventral connecting rod that bends (or branches) to give rise to the anterolateral rod and in some echinoid species to the recurrent rod." [] synonym: " anterior tip of dorsoventral connecting rod" EXACT [] synonym: "anterior end of dorsoventral connecting rod" EXACT [] is_a: ECAO:0104060 ! skeletal element relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111160 name: right dorsoventral connecting rod animal tip def: "The animal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111150 ! dorsoventral connecting rod animal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111170 name: left dorsoventral connecting rod animal tip def: "The animal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111150 ! dorsoventral connecting rod animal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111180 name: dorsoventral connecting rod distal tip def: "The distal tip of a dorsoventral connecting rod, i.e. in connection with the anterolateral rod and in some echinoid species the recurrent rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111190 name: right dorsoventral connecting rod distal tip def: "The distal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111200 name: left dorsoventral connecting rod distal tip def: "The distal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111210 name: dorsoventral connecting rod proximal tip def: "The proximal tip of a dorsoventral connecting rod, i.e. in connection with the anonymous and ventral transverse rods." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111220 name: right dorsoventral connecting rod proximal tip def: "The proximal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111230 name: left dorsoventral connecting rod proximal tip def: "The proximal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111240 name: dorsoventral connecting rod middle portion def: "The middle portion of a dorsoventral connecting rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111250 name: right dorsoventral connecting rod middle portion def: "The middle portion of a right dorsoventral connecting rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111260 name: left dorsoventral connecting rod middle portion def: "The middle portion of a left dorsoventral connecting rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111270 name: dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a dorsoventral connecting rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0107990 ! dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111280 name: right dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right dorsoventral connecting rod." [] is_a: ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105738 ! right dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111290 name: left dorsoventral connecting rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left dorsoventral connecting rod." [] is_a: ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105748 ! left dorsoventral connecting rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111300 name: dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of the bended portion of a dorsoventral connecting rod, before this portion elongates and becomes an anterolateral rod or in some echinoid species branches into a anterolateral and a recurrent rods." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111270 ! dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111310 name: right dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the animal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111300 ! dorsoventral connecting rod animal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111280 ! right dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111320 name: left dorsoventral connecting rod animal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the animal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111300 ! dorsoventral connecting rod animal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111290 ! left dorsoventral connecting rod skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111330 name: dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a dorsoventral connecting rod, before its bended portion." [] is_a: ECAO:0110180 ! skeletal rod distal tip skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111180 ! dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111340 name: right dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111330 ! dorsoventral connecting rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111190 ! right dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111350 name: left dorsoventral connecting rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111330 ! dorsoventral connecting rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111200 ! left dorsoventral connecting rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111360 name: dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a dorsoventral connecting rod, in the vicinity of an anonymous and ventral transverse rod." [] is_a: ECAO:0110190 ! skeletal rod proximal tip skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111210 ! dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111370 name: right dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right dorsoventral connecting rod." [] is_a: ECAO:0111360 ! dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111220 ! right dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111380 name: left dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left dorsoventral connecting rod." [] is_a: ECAO:0111360 ! dorsoventral connecting rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111230 ! left dorsoventral connecting rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111390 name: dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a dorsoventral connecting rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111240 ! dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111400 name: right dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right dorsoventral connecting rod." [] is_a: ECAO:0111390 ! dorsoventral connecting rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111250 ! right dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111410 name: left dorsoventral connecting rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left dorsoventral connecting rod." [] is_a: ECAO:0111390 ! dorsoventral connecting rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111260 ! left dorsoventral connecting rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111420 name: ventral transverse rod distal tip def: "The distal tip of a ventral transverse rod, i.e. away from the connection with the dorsoventral connecting and anonymous rods." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111430 name: right ventral transverse rod distal tip def: "The distal tip of a right ventral transverse rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111440 name: left ventral transverse rod distal tip def: "The distal tip of a left ventral transverse rod." [] is_a: ECAO:0111180 ! dorsoventral connecting rod distal tip relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111450 name: ventral transverse rod proximal tip def: "The proximal tip of a ventral transverse rod, i.e. in connection with the dorsoventral connecting and anonymous rods." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111460 name: right ventral transverse rod proximal tip def: "The proximal tip of a right ventral transverse rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111470 name: left ventral transverse rod proximal tip def: "The proximal tip of a left ventral transverse rod." [] is_a: ECAO:0111210 ! dorsoventral connecting rod proximal tip relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111480 name: ventral transverse rod middle portion def: "The middle portion of a ventral transverse rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111490 name: right ventral transverse rod middle portion def: "The middle portion of a right ventral transverse rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111500 name: left ventral transverse rod middle portion def: "The middle portion of a left ventral transverse rod." [] is_a: ECAO:0111240 ! dorsoventral connecting rod middle portion relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111510 name: ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0108000 ! ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111520 name: right ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right ventral transverse rod." [] is_a: ECAO:0111510 ! ventral transverse rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105850 ! right ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111530 name: left ventral transverse rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left ventral transverse rod." [] is_a: ECAO:0111510 ! ventral transverse rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105860 ! left ventral transverse rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111540 name: ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111420 ! ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111550 name: right ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right ventral transverse rod." [] is_a: ECAO:0111540 ! ventral transverse rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111430 ! right ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111560 name: left ventral transverse rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left ventral transverse rod." [] is_a: ECAO:0111540 ! ventral transverse rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111440 ! left ventral transverse rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111570 name: ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a ventral transverse rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111450 ! ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111580 name: right ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right ventral transverse rod." [] is_a: ECAO:0111570 ! ventral transverse rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0111460 ! right ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111590 name: left ventral transverse rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left ventral transverse rod." [] is_a: ECAO:0111570 ! ventral transverse rod proximal tip skeletogenic mesenchyme cell relationship: existence_starts_during ECAO:0000410 ! late gastrula stage relationship: part_of ECAO:0111470 ! left ventral transverse rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111600 name: ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a ventral transverse rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0111480 ! ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111610 name: right ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right ventral transverse rod." [] is_a: ECAO:0111600 ! ventral transverse rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111490 ! right ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111620 name: left ventral transverse rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left ventral transverse rod." [] is_a: ECAO:0111600 ! ventral transverse rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111500 ! left ventral transverse rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111630 name: body rod distal tip def: "The growing tip of a body rod as it extends dorsally away from an anonymous rod." [] synonym: " body rod distal tip" EXACT [] synonym: "posterior tip body rod" EXACT [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111640 name: right body rod distal tip def: "The distal tip of a right body rod." [] synonym: "right body rod distal tip" EXACT [] is_a: ECAO:0111630 ! body rod distal tip relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111650 name: left body rod distal tip def: "The distal tip of a left body rod." [] synonym: "left body rod distal tip" EXACT [] is_a: ECAO:0111630 ! body rod distal tip relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111660 name: body rod proximal tip def: "The proximal tip of a body rod, i.e. in connection with an anonymous rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111670 name: right body rod proximal tip def: "The proximal tip of a right body rod." [] is_a: ECAO:0111660 ! body rod proximal tip relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111680 name: left body rod proximal tip def: "The proximal tip of a left body rod." [] is_a: ECAO:0111660 ! body rod proximal tip relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111690 name: body rod middle portion def: "The middle portion of a body rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111700 name: right body rod middle portion def: "The middle portion of a right body rod." [] is_a: ECAO:0111690 ! body rod middle portion relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111710 name: left body rod middle portion def: "The middle portion of a left body rod." [] is_a: ECAO:0111690 ! body rod middle portion relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111720 name: body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0105880 ! body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111730 name: right body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right body rod." [] is_a: ECAO:0111720 ! body rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105900 ! right body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111740 name: left body rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left body rod." [] is_a: ECAO:0111720 ! body rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105890 ! left body rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111750 name: body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111630 ! body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111760 name: right body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right body rod." [] is_a: ECAO:0111750 ! body rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111640 ! right body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111770 name: left body rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left body rod." [] is_a: ECAO:0111750 ! body rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111650 ! left body rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111780 name: body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a body rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111660 ! body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111790 name: right body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right body rod." [] is_a: ECAO:0111780 ! body rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111670 ! right body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111800 name: left body rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left body rod." [] is_a: ECAO:0111780 ! body rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111680 ! left body rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111810 name: body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a body rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0111690 ! body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111820 name: right body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right body rod." [] is_a: ECAO:0111810 ! body rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111700 ! right body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111830 name: left body rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left body rod." [] is_a: ECAO:0111810 ! body rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111710 ! left body rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111840 name: scheitel skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a scheitel." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0105870 ! scheitel property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111850 name: recurrent rod distal tip def: "The distal tip of a recurrent rod, i.e. in connection with a dorsoventral connecting rod." [] is_a: ECAO:0110100 ! skeletal rod distal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111860 name: right recurrent rod distal tip def: "The distal tip of a right recurrent rod." [] is_a: ECAO:0111850 ! recurrent rod distal tip relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111870 name: left recurrent rod distal tip def: "The distal tip of a left recurrent rod." [] is_a: ECAO:0111850 ! recurrent rod distal tip relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111880 name: recurrent rod proximal tip def: "The proximal tip of a recurrent rod, i.e. away from a dorsoventral connecting rod." [] is_a: ECAO:0110110 ! skeletal rod proximal tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111890 name: right recurrent rod proximal tip def: "The proximal tip of a right recurrent rod." [] is_a: ECAO:0111880 ! recurrent rod proximal tip relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111900 name: left recurrent rod proximal tip def: "The proximal tip of a left recurrent rod." [] is_a: ECAO:0111880 ! recurrent rod proximal tip relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111910 name: recurrent rod middle portion def: "The middle portion of a recurrent rod, i.e., comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110120 ! skeletal rod middle portion relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111920 name: right recurrent rod middle portion def: "The middle portion of a right recurrent rod." [] is_a: ECAO:0111910 ! recurrent rod middle portion relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111930 name: left recurrent rod middle portion def: "The middle portion of a left recurrent rod." [] is_a: ECAO:0111910 ! recurrent rod middle portion relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111940 name: recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0108040 ! recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111950 name: right recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a right recurrent rod." [] is_a: ECAO:0111940 ! recurrent rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105940 ! right recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111960 name: left recurrent rod skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell part of a left recurrent rod." [] is_a: ECAO:0111940 ! recurrent rod skeletogenic mesenchyme cell relationship: part_of ECAO:0105950 ! left recurrent rod property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111970 name: recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111850 ! recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111980 name: right recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a right recurrent rod." [] is_a: ECAO:0111970 ! recurrent rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111860 ! right recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0111990 name: left recurrent rod distal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the distal tip of a left recurrent rod." [] is_a: ECAO:0111970 ! recurrent rod distal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111870 ! left recurrent rod distal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112000 name: recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a recurrent rod." [] is_a: ECAO:0110170 ! skeletal rod skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111880 ! recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112010 name: right recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a right recurrent rod." [] is_a: ECAO:0112000 ! recurrent rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111890 ! right recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112020 name: left recurrent rod proximal tip skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the proximal tip of a left recurrent rod." [] is_a: ECAO:0112000 ! recurrent rod proximal tip skeletogenic mesenchyme cell relationship: part_of ECAO:0111900 ! left recurrent rod proximal tip property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112030 name: recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a recurrent rod, comprised between the distal and proximal tips of the rod." [] is_a: ECAO:0110200 ! skeletal rod middle portion skeletogenic mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0111910 ! recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112040 name: right recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a right recurrent rod." [] is_a: ECAO:0112030 ! recurrent rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111920 ! right recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112050 name: left recurrent rod middle portion skeletogenic mesenchyme cell def: "A skeletogenic mesenchyme cell composing the middle portion of a left recurrent rod." [] is_a: ECAO:0112030 ! recurrent rod middle portion skeletogenic mesenchyme cell relationship: part_of ECAO:0111930 ! left recurrent rod middle portion property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112060 name: enoderm cell def: "A cell part of the endoderm germ layer." [] synonym: "endodermal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112070 name: vegetal tier 1 endoderm def: "The presumptive endoderm that develops specifically from the cells of the vegetal tier 1." [] synonym: " veg1 endoderm" EXACT [] synonym: "veg1 endo" EXACT [] is_a: ECAO:0106010 ! presumptive endoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105220 ! ectoendoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112080 name: vegetal tier 2 endoderm def: "The presumptive endoderm that develops specifically from the cells of the vegetal tier 2." [] synonym: " veg2 endoderm" EXACT [] synonym: "veg2 endo" EXACT [] is_a: ECAO:0106010 ! presumptive endoderm is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105230 ! endomesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112090 name: embryonic endoderm def: "The endoderm that is specifically present in an embryo." [] is_a: ECAO:0106020 ! endoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112100 name: larval endoderm def: "The endoderm that is specifically present in a larva." [] is_a: ECAO:0106020 ! endoderm relationship: develops_from ECAO:0112090 ! embryonic endoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112110 name: pre-metamorphic organism endoderm def: "The endoderm that is specifically present in an embryo post-gastrulation and a larva but not in an adult." [] is_a: ECAO:0106020 ! endoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112120 name: archenteron tip def: "The anterior territory of the archenteron." [] synonym: " anterior archenteron" EXACT [] synonym: " tip of archetron" EXACT [] synonym: "archenteron roof" EXACT [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112130 name: archenteron wall def: "The layer of cells that form the archenteron, but at the level of its anterior tip and that of the blastopore." [] is_a: ECAO:0104070 ! embryonic structure relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112140 name: middle hindgut def: "The middle portion of the hindgut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106040 ! hindgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112150 name: middle midgut def: "The middle portion of the midgut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106070 ! midgut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112160 name: middle foregut def: "The middle portion of the foregut, between its anterior and posterior portions." [] is_a: ECAO:0109080 ! embryonic region relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0106140 ! foregut property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112170 name: esophagus def: "The anterior end of the animal digestive tract that connects the mouth to the stomach." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112180 name: stomach def: "The central region of the animal digestive tract that serves as a digestive organ." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112190 name: intestine def: "The posterior region of the animal digestive tract that extends from the stomach to the anus." [] is_a: ECAO:0104050 ! digestive system element relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0109060 ! post-embryonic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112200 name: coelomic evagination def: "The outpocketing of the mesoderm constituting the tip of the archenteron and forming a bilobed bag (or pouch) lying on the top of the archenteron roof." [] synonym: " unpaire evagination of the coelom" EXACT [] synonym: " unpaired coelomic evaginations" EXACT [] synonym: " unpaired coelomic outpocketing" EXACT [] synonym: " unpaired coelomic rudiment" EXACT [] synonym: "unpaired coelomic pouch" EXACT [] is_a: ECAO:0103510 ! anatomical structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112120 ! archenteron tip relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112210 name: coelomic pouch def: "A mesodermally lined pouch (or pocket) lying between the anterior tip of the archenteron and the outer body wall." [] is_a: ECAO:0106770 ! coelom relationship: develops_from ECAO:0112120 ! archenteron tip relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0109050 ! pre-metamorphic organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112220 name: constriction def: "A narrowing (or shrinking) within a tissue or organ to delineate different regions with different fates." [] is_a: ECAO:0109000 ! anatomical element relationship: existence_starts_during ECAO:0000426 ! stage 18 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112230 name: coelomic constriction def: "A constriction taking place at the level of a coelom. It can either separate the coelom from the archenteron or lead to the compartmentalization of the coelom into distinct regions." [] synonym: "coelom constriction" EXACT [] is_a: ECAO:0112220 ! constriction relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0106770 ! coelom property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112240 name: anterior coelomic pouch def: "In species with a posterior enterocoel, the anterior coelomic pouch is the one that develops from the unpaired coelomic evaginations at the tip of the archenteron." [] is_a: ECAO:0112210 ! coelomic pouch relationship: develops_from ECAO:0112200 ! coelomic evagination relationship: existence_starts_during ECAO:0000424 ! stage 17 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112250 name: larval epidermis def: "An epidermal tissue present in the larva." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0104908 ! ectoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112260 name: ventral epiderms def: "The epidermal tissue of the larva that surrounds the mouth." [] synonym: " circumoral ectoderm" EXACT [] synonym: " circumoral epithelium" EXACT [] synonym: "oral epidermis" EXACT [] is_a: ECAO:0106828 ! larval epithelium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105200 ! ventral ectoderm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112270 name: dorsal epidermis def: "The epidermal tissue of the larva that is on the side opposite to the mouth." [] synonym: "aboral epidermis" EXACT [] is_a: ECAO:0106828 ! larval epithelium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105210 ! dorsal ectoderm relationship: existence_starts_during ECAO:0000428 ! stage 19 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112280 name: mesenchyme def: "A tissue composed of mesenchymal cells." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112290 name: mesenchyme cell def: "A cell that has undergone epithelial to mesenchymal transition and is capable of migration." [] synonym: " migratory cell" EXACT [] synonym: " motile cell" EXACT [] synonym: "mesenchymal cell" EXACT [] is_a: ECAO:0104030 ! cell is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112300 name: presumptive skeletogenic mesoderm def: "The region of the early embryo that will develop into skeletogenic mesoderm." [] is_a: ECAO:0106200 ! presumptive mesoderm relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_ends_during ECAO:0000395 ! stage 14 relationship: existence_starts_during ECAO:0000195 ! stage 6 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112310 name: skeletogenic mesoderm def: "The subset of the mesoderm germ layer that will exclusively give rise to the endoskeleton." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112300 ! presumptive skeletogenic mesoderm relationship: part_of ECAO:0106210 ! mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112320 name: skeletogenic mesoderm cell def: "A cell that has the potential of developing into a skeletogenic mesenchyme cell (or skeletal cell)." [] synonym: "skeletogenic cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112310 ! skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112330 name: skeletogenic mesenchyme def: "The portion of the mesenchyme tissue that constitutes the endoskeleton." [] is_a: ECAO:0104110 ! tissue is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0112310 ! skeletogenic mesoderm relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112340 name: skeletogenic mesenchyme cell def: "A cell that after having undergone epithelial to mesenchymal transition participates in constituting the endoskeleton." [] synonym: "skeletal cell" EXACT [] is_a: ECAO:0104030 ! cell relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0112330 ! skeletogenic mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112350 name: syncytial filipodial cable def: "A filopodial cable that participates in the establishment of a syncytium." [] synonym: " syncytial cable" EXACT [] synonym: "syncytial lamellipodia" EXACT [] is_a: ECAO:0104110 ! tissue relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106250 ! syncytium property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112360 name: chain of skeletogenic mesenchyme cell def: "A straight, syncitial network that either links the two ventrolateral skeletogenic mesenchyme clusters within the subequatorial skeletogenic mesenchyme ring or extends from the ventrolateral skeletogenic mesenchyme clusters towards the animal pole domain." [] is_a: ECAO:0104070 ! embryonic structure is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105698 ! embryonic skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0106270 ! subequatorial skeletogenic mesenchyme ring property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112370 name: oral chain of skeletogenic mesenchyme cell def: "The chain of skeletogenic mesenchyme cell that within the subequatorial skeletogenic mesenchyme ring links the two ventrolateral skeletogenic mesenchyme clusters on the oral side of the embryo. The ventral transverse rods will be deposited along this cellular strand." [] synonym: " oral chain of PMCs" EXACT [] synonym: " ventral skeletogenic mesenchyme chain" EXACT [] synonym: "ventral chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112380 name: aboral chain of skeletogenic mesenchyme cell def: "The chain of skeletogenic mesenchyme cell that within the subequatorial skeletogenic mesenchyme ring links the two ventrolateral skeletogenic mesenchyme clusters on the aboral side of the embryo. The body rods will be deposited along this cellular strand." [] synonym: " aboral chain of PMCs" EXACT [] synonym: " dorsal skeletogenic mesenchyme chain" EXACT [] synonym: "dorsal chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112390 name: skeletogenic mesenchyme cluster def: "A cluster of skeletogenic mesenchyme cells that aggregates before any calcification event whether in the embryo, the larva, or the adult." [] is_a: ECAO:0103510 ! anatomical structure relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103560 ! multicellular organism property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112400 name: lateral chain of skeletogenic mesenchyme cell def: "A chain of skeletogenic mesenchyme cell that extends from a ventrolateral cluster toward the animal pole. A dorsoventral connecting rod will be deposited along this cellular strand." [] synonym: "lateral chain of PMCs" EXACT [] is_a: ECAO:0112360 ! chain of skeletogenic mesenchyme cell relationship: develops_from ECAO:0106240 ! embryonic skeletogenic mesenchyme cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112410 name: right lateral chain of skeletogenic mesenchyme cell def: "The lateral chain that forms on the right side of the embryo from the right ventrolateral cluster." [] synonym: "right lateral chain of PMCs" EXACT [] is_a: ECAO:0106320 ! lateral chain of skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112420 name: left lateral chain of skeletogenic mesenchyme cell def: "The lateral chain that forms on the left side of the embryo from the left ventrolateral cluster." [] synonym: "left lateral chain of PMCs" EXACT [] is_a: ECAO:0106320 ! lateral chain of skeletogenic mesenchyme relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112430 name: triradiate spicule def: "A skeletal, calcified structure composed of three elongated skeletal rods." [] synonym: "triradiate element" EXACT [] is_a: ECAO:0104060 ! skeletal element is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0105650 ! triradiate spicule rudiment relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112440 name: ventrolateral spicule granule def: "A spicule granule that forms within a ventrolateral cluster of skeletogenic mesenchyme cells." [] is_a: ECAO:0105630 ! spicule granule is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0108060 ! ventrolateral skeletogenic mesenchyme cluster relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103820 ! embryonic endoskeleton property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112450 name: right ventrolateral spicule granule def: "A ventrolateral spicule granule that forms on the right side of the embryo." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0106300 ! right ventrolateral skeletogenic mesenchyme cluster property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112460 name: left ventrolateral spicule granule def: "A ventrolateral spicule granule that forms on the left side of the embryo." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0106310 ! left ventrolateral skeletogenic mesenchyme cluster property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112470 name: ventrolateral triradiate spicule rudiment def: "A triradiate spicule rudiment that forms within a ventrolateral cluster of skeletogenic mesenchyme cells." [] is_a: ECAO:0112440 ! ventrolateral spicule granule relationship: develops_from ECAO:0112440 ! ventrolateral spicule granule relationship: existence_starts_during ECAO:0000405 ! stage 15 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112480 name: presumptive non-skeletogenic mesoderm def: "An embryonic, larval or adult region that will develop into non-skeletogenic mesoderm and/or mesenchyme derivatives." [] is_a: ECAO:0106200 ! presumptive mesoderm relationship: develops_from ECAO:0106210 ! mesoderm relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000284 ! stage 11 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112490 name: non-skeletogenic mesoderm def: "The subset of the mesoderm germ layer that will give rise to all mesoderm tissue derivatives but the endoskeleton; e.g. muscles, coeloms, pigment cells, blastocoelar cells." [] is_a: ECAO:0106210 ! mesoderm relationship: develops_from ECAO:0112480 ! presumptive non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000422 ! stage 16 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112500 name: non-skeletogenic mesoderm cell def: "A cell part of the mesoderm germ layer subset that will give rise to all mesoderm tissue derivatives but the endoskeleton; e.g. muscles, coeloms, pigment cells, blastocoelar cells." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000424 ! stage 17 relationship: existence_starts_during ECAO:0000422 ! stage 16 relationship: part_of ECAO:0112490 ! non-skeletogenic mesoderm property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112510 name: non-skeletogenic mesenchyme def: "All mesenchyme present in the embryo, larva, or adult but that does not constitute the endoskeleton." [] is_a: ECAO:0112280 ! mesenchyme relationship: develops_from ECAO:0112490 ! non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112520 name: non-skeletogenic mesenchyme cell def: "A mesenchymal cell that participates in the elaboration of all mesenchyme derivatives but the endoskeleton; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0104030 ! cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0112280 ! mesenchyme property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112530 name: vegetal tier 2 non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that derives from the vegetal 2 tier cells and not from the small micromere descendants." [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: develops_from ECAO:0105100 ! vegetal tier 2 relationship: existence_ends_during ECAO:0000405 ! stage 15 relationship: existence_starts_during ECAO:0000284 ! stage 11 property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112540 name: embryonic mesenchyme cell def: "In echinoderms with no embryonic endoskeleton, all embryonic cells that have undergone an epithelial-to-mesenchymal transition and will participate in the elaboration of non-skeletogenic mesoderm derivatives; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000385 ! stage 13 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112550 name: larval mesenchyme cell def: "In echinoderms with no larval endoskeleton, all larval mesenchyme cells that participate in the elaboration of non-skeletogenic mesoderm derivatives; e.g. pigment cells, blastocoelar cells." [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0103580 ! larva property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112560 name: oral presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that in the vegetal plate is on the oral side of the embryo." [] synonym: " oral non-skeletogenic mesoderm" EXACT [] synonym: " ventral non-skeletogenic mesoderm" EXACT [] synonym: "ventral presumptive embryonic non-skeletogenic mesoderm" EXACT [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112570 name: aboral presumptive embryonic non-skeletogenic mesoderm def: "The presumptive embryonic non-skeletogenic mesoderm that in the vegetal plate is on the aboral side of the embryo." [] synonym: " aboral non-skeletogenic mesoderm" EXACT [] synonym: " dorsal non-skeletogenic mesoderm" EXACT [] synonym: "dorsal presumptive embryonic non-skeletogenic mesoderm" EXACT [] is_a: ECAO:0108070 ! presumptive embryonic non-skeletogenic mesoderm relationship: existence_ends_during ECAO:0000385 ! stage 13 relationship: existence_starts_during ECAO:0000286 ! stage 12 relationship: part_of ECAO:0104020 ! vegetal plate property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112580 name: immune cell def: "A cell of the immune system that is involved in protecting the body against infectious disease and foreign invaders." [] synonym: "immunocyte" EXACT [] is_a: ECAO:0112290 ! mesenchyme cell relationship: existence_starts_during ECAO:0000405 ! stage 15 relationship: part_of ECAO:0103660 ! immune system property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112590 name: phagocytic filopodial cell def: "The subset of the filopodial cells that are phagocytic and express the immune effector gene 185/333." [] is_a: ECAO:0106510 ! filopodial cell relationship: develops_from ECAO:0106490 ! blastocoelar cell property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112600 name: sphincter primordium def: "An initial constriction within the archenteron marking where a sphincter will form." [] synonym: " gut constriction" EXACT [] synonym: "sphincter constriction" EXACT [] is_a: ECAO:0112220 ! constriction relationship: existence_ends_during ECAO:0000426 ! stage 18 relationship: part_of ECAO:0103570 ! embryo property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112610 name: pyloric sphincter primordium def: "The initial constriction within the archenteron that will develop into the pyloric sphincter and separates the midgut and hindgut." [] synonym: " midgut-hindgut constriction" EXACT [] synonym: " pyloric constriction" EXACT [] synonym: "pyloric sphincter constriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium relationship: existence_ends_during ECAO:0000428 ! stage 19 relationship: existence_starts_during ECAO:0000428 ! stage 19 relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112620 name: cardiac sphincter primordium def: "The initial constriction within the archenteron that will develop into the cardiac sphincter and separates the foregut and the midgut." [] synonym: " cardiac constriction" EXACT [] synonym: " foregut-midgut constriction" EXACT [] synonym: "cardiac sphincter constriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium relationship: part_of ECAO:0106030 ! archenteron property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112630 name: anal sphincter primordium def: "The initial constriction at the posterior end of the archenteron (i.e. at the level of the blastopore) that will develop into the anal sphincter." [] synonym: " anal constriction" EXACT [] synonym: "anal sphincter contriction" EXACT [] is_a: ECAO:0112600 ! sphincter primordium is_a: UBERON:0001062 ! anatomical entity relationship: develops_from ECAO:0106030 ! archenteron relationship: existence_ends_during ECAO:0000440 ! larval development relationship: existence_starts_during ECAO:0000440 ! larval development property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112640 name: sphincter cell def: "A cell that is part of a sphincter." [] synonym: "myoepithelial cell" EXACT [] is_a: ECAO:0108110 ! muscle cell relationship: existence_ends_during ECAO:0000440 ! larval development relationship: part_of ECAO:0106610 ! sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112650 name: pyloric sphincter cell def: "A cell that is part of a pyloric sphincter." [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106620 ! pyloric sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112660 name: cardiac sphincter cell def: "A cell that is part of a cardiac sphincter." [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106630 ! cardiac sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: ECAO:0112670 name: anal sphincter cell def: "A cell that is part of an anal sphincter." [] synonym: "anal pore muscle cell" EXACT [] is_a: ECAO:0112640 ! sphincter cell relationship: part_of ECAO:0106640 ! anal sphincter property_value: oio:hasOBONamespace "echinoderm_anatomy" xsd:string [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005773 ! vacuole relationship: results_in_distribution_of GO:0005773 ! vacuole property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] synonym: "Golgi apparatus membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: bounding_layer_of GO:0005794 ! Golgi apparatus relationship: bounding_layer_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0015630 ! microtubule cytoskeleton relationship: results_in_organization_of GO:0015630 ! microtubule cytoskeleton property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23114 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23195 xsd:anyURI [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18154 ! polysaccharide relationship: has_primary_output CHEBI:18154 ! polysaccharide [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process alt_id: GO:0044244 def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:18154 ! polysaccharide relationship: has_primary_input CHEBI:18154 ! polysaccharide [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005634 ! nucleus relationship: results_in_fission_of GO:0005634 ! nucleus [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: results_in_fusion_of GO:0031965 ! nuclear membrane relationship: results_in_fusion_of GO:0031965 ! nuclear membrane [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion intersection_of: results_in_fusion_of GO:0005634 ! nucleus relationship: part_of GO:0006997 ! nucleus organization relationship: results_in_fusion_of GO:0005634 ! nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation intersection_of: has_part GO:0045026 ! plasma membrane fusion [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0000789 alt_id: GO:0000790 alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0032993 ! protein-DNA complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component alt_id: GO:0005720 alt_id: GO:0035328 def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] synonym: "nuclear heterochromatin" NARROW [] synonym: "transcriptionally inactive chromatin" EXACT [] synonym: "transcriptionally silent chromatin" EXACT [] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22355 xsd:anyURI [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:0000000 ! cell relationship: results_in_morphogenesis_of CL:0000000 ! cell [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0001434 ! skeletal system relationship: results_in_development_of UBERON:0001434 ! skeletal system [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: results_in_formation_of_anatomical_entity UBERON:0001474 ! bone element relationship: results_in_formation_of_anatomical_entity UBERON:0001474 ! bone element [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel relationship: part_of GO:0048514 ! blood vessel morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: results_in_growth_of CL:0000023 ! oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: results_in_growth_of CL:0000023 ! oocyte [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of CL:0000023 ! oocyte relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0048599 ! oocyte development relationship: results_in_maturation_of CL:0000023 ! oocyte [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: part_of GO:0051716 ! cellular response to stimulus relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0001981 ! blood vessel relationship: part_of GO:0001944 ! vasculature development relationship: results_in_development_of UBERON:0001981 ! blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel relationship: part_of GO:0048514 ! blood vessel morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: has_participant GO:0005874 ! microtubule relationship: results_in_formation_of_anatomical_entity GO:0097427 ! microtubule bundle [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000970 ! eye relationship: part_of GO:0150063 ! visual system development relationship: results_in_development_of UBERON:0000970 ! eye [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004122 ! genitourinary system relationship: has_part GO:0072001 ! renal system development relationship: results_in_development_of UBERON:0004122 ! genitourinary system property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22178 xsd:anyURI [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: part_of CL:0000021 ! female germ cell relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of CL:0000021 ! female germ cell [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0044207 ! translation initiation ternary complex relationship: part_of GO:0006413 ! translational initiation relationship: results_in_assembly_of GO:0044207 ! translation initiation ternary complex [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: in_taxon NCBITaxon:50557 ! Insecta relationship: only_in_taxon NCBITaxon:50557 ! Insecta [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: in_taxon NCBITaxon:32525 ! Theria relationship: only_in_taxon NCBITaxon:32525 ! Theria [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0000923 ! germ layer relationship: part_of GO:0007369 ! gastrulation relationship: results_in_formation_of_anatomical_entity UBERON:0000923 ! germ layer [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0000924 ! ectoderm relationship: part_of GO:0007398 ! ectoderm development relationship: results_in_formation_of_anatomical_entity UBERON:0000924 ! ectoderm [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0000925 ! endoderm relationship: part_of GO:0007492 ! endoderm development relationship: results_in_formation_of_anatomical_entity UBERON:0000925 ! endoderm [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0000926 ! mesoderm relationship: part_of GO:0048332 ! mesoderm morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0000926 ! mesoderm [Term] id: GO:0001743 name: lens placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] synonym: "optic placode formation" RELATED [] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0003073 ! lens placode relationship: part_of GO:0048598 ! embryonic morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0003073 ! lens placode [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0000018 ! compound eye relationship: in_taxon NCBITaxon:6656 ! Arthropoda relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of GO:0048749 ! compound eye development relationship: results_in_morphogenesis_of UBERON:0000018 ! compound eye [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:2000019 ! compound eye photoreceptor cell relationship: part_of GO:0001745 ! compound eye morphogenesis relationship: results_in_acquisition_of_features_of CL:2000019 ! compound eye photoreceptor cell [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000287 ! eye photoreceptor cell relationship: part_of GO:0048592 ! eye morphogenesis relationship: results_in_acquisition_of_features_of CL:0000287 ! eye photoreceptor cell [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002329 ! somite relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development relationship: results_in_formation_of_anatomical_entity UBERON:0002329 ! somite [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: acts_on_population_of CL:0000738 ! leukocyte relationship: acts_on_population_of CL:0000738 ! leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+) [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000358 ! blastocyst relationship: in_taxon NCBITaxon:32525 ! Theria relationship: only_in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001701 ! in utero embryonic development relationship: results_in_development_of UBERON:0000358 ! blastocyst [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0000358 ! blastocyst relationship: part_of GO:0001824 ! blastocyst development relationship: results_in_formation_of_anatomical_entity UBERON:0000358 ! blastocyst [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell relationship: part_of GO:0001825 ! blastocyst formation relationship: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell relationship: part_of GO:0001825 ! blastocyst formation relationship: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell relationship: part_of GO:0001829 ! trophectodermal cell differentiation relationship: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: results_in_growth_of UBERON:0000358 ! blastocyst relationship: part_of GO:0001824 ! blastocyst development relationship: results_in_growth_of UBERON:0000358 ! blastocyst [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: acts_on_population_of CL:2000020 ! inner cell mass cell relationship: acts_on_population_of CL:2000020 ! inner cell mass cell relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: acts_on_population_of CL:1000274 ! trophectodermal cell relationship: acts_on_population_of CL:1000274 ! trophectodermal cell relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: has_primary_input CL:0000066 ! epithelial cell intersection_of: results_in_acquisition_of_features_of CL:0008019 ! mesenchymal cell relationship: has_primary_input CL:0000066 ! epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0003075 ! neural plate relationship: part_of GO:0001840 ! neural plate development relationship: results_in_morphogenesis_of UBERON:0003075 ! neural plate [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0003075 ! neural plate relationship: part_of GO:0043009 ! chordate embryonic development relationship: results_in_development_of UBERON:0003075 ! neural plate [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0001049 ! neural tube relationship: part_of GO:0021915 ! neural tube development relationship: results_in_formation_of_anatomical_entity UBERON:0001049 ! neural tube [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0005062 ! neural fold relationship: part_of GO:0014020 ! primary neural tube formation relationship: results_in_formation_of_anatomical_entity UBERON:0005062 ! neural fold [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. is_a: GO:0009620 ! response to fungus intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input NCBITaxon:147537 ! Saccharomycotina relationship: has_primary_input NCBITaxon:147537 ! Saccharomycotina [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000115 ! endothelial cell relationship: part_of GO:0045446 ! endothelial cell differentiation relationship: results_in_development_of CL:0000115 ! endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:0000115 ! endothelial cell relationship: part_of GO:0001885 ! endothelial cell development relationship: results_in_morphogenesis_of CL:0000115 ! endothelial cell [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002107 ! liver relationship: part_of GO:0061008 ! hepaticobiliary system development relationship: results_in_development_of UBERON:0002107 ! liver [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: acts_on_population_of CL:0000115 ! endothelial cell relationship: acts_on_population_of CL:0000115 ! endothelial cell [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001935 ! endothelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002049 ! vasculature relationship: part_of GO:0072359 ! circulatory system development relationship: results_in_development_of UBERON:0002049 ! vasculature [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of UBERON:0001981 ! blood vessel relationship: part_of GO:0001568 ! blood vessel development relationship: results_in_maturation_of UBERON:0001981 ! blood vessel [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0000483 ! epithelium relationship: part_of GO:0060429 ! epithelium development relationship: results_in_morphogenesis_of UBERON:0000483 ! epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0010136 ! epithelial sheet relationship: results_in_morphogenesis_of UBERON:0010136 ! epithelial sheet [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006814 ! sodium ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000138 ! chondrocyte relationship: part_of GO:0051216 ! cartilage development relationship: results_in_acquisition_of_features_of CL:0000138 ! chondrocyte [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000138 ! chondrocyte relationship: part_of GO:0002062 ! chondrocyte differentiation relationship: results_in_development_of CL:0000138 ! chondrocyte [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000066 ! epithelial cell relationship: part_of GO:0030855 ! epithelial cell differentiation relationship: results_in_development_of CL:0000066 ! epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000075 ! columnar/cuboidal epithelial cell relationship: results_in_acquisition_of_features_of CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000075 ! columnar/cuboidal epithelial cell relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation relationship: results_in_development_of CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000150 ! glandular epithelial cell relationship: results_in_acquisition_of_features_of CL:0000150 ! glandular epithelial cell [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000150 ! glandular epithelial cell relationship: part_of GO:0002067 ! glandular epithelial cell differentiation relationship: results_in_development_of CL:0000150 ! glandular epithelial cell [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development relationship: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of CL:0000066 ! epithelial cell relationship: part_of GO:0002064 ! epithelial cell development relationship: results_in_maturation_of CL:0000066 ! epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of CL:0000150 ! glandular epithelial cell relationship: part_of GO:0002068 ! glandular epithelial cell development relationship: results_in_maturation_of CL:0000150 ! glandular epithelial cell [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0003072 ! optic cup relationship: part_of GO:0060900 ! embryonic camera-type eye formation relationship: results_in_morphogenesis_of UBERON:0003072 ! optic cup [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000965 ! lens of camera-type eye relationship: part_of GO:0043010 ! camera-type eye development relationship: results_in_development_of UBERON:0000965 ! lens of camera-type eye [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0000965 ! lens of camera-type eye relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: results_in_morphogenesis_of UBERON:0000965 ! lens of camera-type eye [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0008001 ! hematopoietic precursor cell relationship: part_of GO:0030097 ! hemopoiesis relationship: results_in_acquisition_of_features_of CL:0008001 ! hematopoietic precursor cell [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18737 xsd:anyURI [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: acts_on_population_of CL:0000763 ! myeloid cell relationship: acts_on_population_of CL:0000763 ! myeloid cell [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000839 ! myeloid lineage restricted progenitor cell relationship: results_in_acquisition_of_features_of CL:0000839 ! myeloid lineage restricted progenitor cell [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0002251 ! organ or tissue specific immune response intersection_of: GO:0006955 ! immune response intersection_of: occurs_in UBERON:0002107 ! liver relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: occurs_in UBERON:0002107 ! liver relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: process_has_causal_agent CL:0000738 ! leukocyte relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: process_has_causal_agent CL:0000738 ! leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: process_has_causal_agent CL:0000766 ! myeloid leukocyte relationship: process_has_causal_agent CL:0000766 ! myeloid leukocyte [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002405 ! immune system relationship: results_in_development_of UBERON:0002405 ! immune system [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000738 ! leukocyte relationship: part_of GO:0030097 ! hemopoiesis relationship: results_in_acquisition_of_features_of CL:0000738 ! leukocyte [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte relationship: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002376 ! immune system process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002376 ! immune system process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002376 ! immune system process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002252 ! immune effector process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002252 ! immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002252 ! immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002443 ! leukocyte mediated immunity relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion intersection_of: has_primary_input CHEBI:60466 ! peptide zwitterion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002790 ! peptide secretion relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002790 ! peptide secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002790 ! peptide secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009607 ! response to biotic stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000304 ! tendon sheath relationship: part_of GO:0035989 ! tendon development relationship: results_in_development_of UBERON:0000304 ! tendon sheath created_by: hjd creation_date: 2012-04-23T02:11:22Z [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0007100 ! primary circulatory organ relationship: part_of GO:0007507 ! heart development relationship: results_in_morphogenesis_of UBERON:0007100 ! primary circulatory organ [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: occurs_in UBERON:0001134 ! skeletal muscle tissue relationship: occurs_in UBERON:0001134 ! skeletal muscle tissue relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] subset: goslim_drosophila subset: goslim_generic synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] subset: goslim_generic synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] subset: goslim_generic synonym: "respiratory gaseous exchange" EXACT [] is_a: GO:0003008 ! system process relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport intersection_of: GO:0006814 ! sodium ion transport intersection_of: occurs_in UBERON:0001008 ! renal system relationship: occurs_in UBERON:0001008 ! renal system [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: has_end_location CL:0000223 ! endodermal cell intersection_of: has_start_location CL:0000222 ! mesodermal cell relationship: has_end_location CL:0000223 ! endodermal cell relationship: has_start_location CL:0000222 ! mesodermal cell created_by: tb creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: has_end_location CL:0000222 ! mesodermal cell intersection_of: has_start_location CL:0000223 ! endodermal cell relationship: has_end_location CL:0000222 ! mesodermal cell relationship: has_start_location CL:0000223 ! endodermal cell created_by: tb creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004139 ! cardiogenic plate relationship: part_of GO:0003007 ! heart morphogenesis relationship: results_in_morphogenesis_of UBERON:0004139 ! cardiogenic plate created_by: tb creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004141 ! heart tube relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development relationship: part_of GO:0048562 ! embryonic organ morphogenesis relationship: results_in_morphogenesis_of UBERON:0004141 ! heart tube created_by: tb creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0004141 ! heart tube relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0004141 ! heart tube created_by: tb creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation created_by: tb creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004142 ! outflow tract septum relationship: part_of GO:0003151 ! outflow tract morphogenesis relationship: results_in_morphogenesis_of UBERON:0004142 ! outflow tract septum created_by: tb creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part relationship: part_of GO:0060412 ! ventricular septum morphogenesis relationship: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part created_by: tb creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004667 ! interventricular septum muscular part relationship: part_of GO:0060412 ! ventricular septum morphogenesis relationship: results_in_morphogenesis_of UBERON:0004667 ! interventricular septum muscular part created_by: tb creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004145 ! outflow tract relationship: part_of GO:0003007 ! heart morphogenesis relationship: results_in_morphogenesis_of UBERON:0004145 ! outflow tract created_by: tb creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: part_of GO:0003144 ! embryonic heart tube formation relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tb creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048645 ! animal organ formation relationship: regulates GO:0048645 ! animal organ formation created_by: tb creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002165 ! endocardium relationship: part_of GO:0007507 ! heart development relationship: results_in_development_of UBERON:0002165 ! endocardium created_by: dph creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0001986 ! endothelium relationship: results_in_development_of UBERON:0001986 ! endothelium created_by: dph creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0001986 ! endothelium relationship: part_of GO:0003158 ! endothelium development relationship: results_in_morphogenesis_of UBERON:0001986 ! endothelium created_by: dph creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002165 ! endocardium relationship: part_of GO:0003157 ! endocardium development relationship: results_in_morphogenesis_of UBERON:0002165 ! endocardium created_by: dph creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002350 ! conducting system of heart relationship: results_in_development_of UBERON:0002350 ! conducting system of heart created_by: dph creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002352 ! atrioventricular node relationship: part_of GO:0003161 ! cardiac conduction system development relationship: results_in_development_of UBERON:0002352 ! atrioventricular node created_by: dph creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002351 ! sinoatrial node relationship: part_of GO:0003161 ! cardiac conduction system development relationship: results_in_development_of UBERON:0002351 ! sinoatrial node created_by: dph creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004146 ! His-Purkinje system relationship: part_of GO:0003161 ! cardiac conduction system development relationship: results_in_development_of UBERON:0004146 ! His-Purkinje system created_by: dph creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002354 ! cardiac Purkinje fiber relationship: part_of GO:0003164 ! His-Purkinje system development relationship: results_in_development_of UBERON:0002354 ! cardiac Purkinje fiber created_by: dph creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0002068 ! Purkinje myocyte relationship: part_of GO:0003165 ! Purkinje myocyte development relationship: results_in_acquisition_of_features_of CL:0002068 ! Purkinje myocyte created_by: dph creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004148 ! cardiac vein relationship: results_in_morphogenesis_of UBERON:0004148 ! cardiac vein created_by: dph creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002062 ! endocardial cushion relationship: part_of GO:0007507 ! heart development relationship: results_in_development_of UBERON:0002062 ! endocardial cushion created_by: dph creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002062 ! endocardial cushion relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development relationship: results_in_morphogenesis_of UBERON:0002062 ! endocardial cushion created_by: dph creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004292 ! cardiac skeleton relationship: part_of GO:0007507 ! heart development relationship: results_in_development_of UBERON:0004292 ! cardiac skeleton created_by: dph creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004151 ! cardiac chamber relationship: part_of GO:0007507 ! heart development relationship: results_in_development_of UBERON:0004151 ! cardiac chamber created_by: dph creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004151 ! cardiac chamber relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development relationship: results_in_morphogenesis_of UBERON:0004151 ! cardiac chamber created_by: dph creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0004151 ! cardiac chamber relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0004151 ! cardiac chamber created_by: dph creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002082 ! cardiac ventricle relationship: part_of GO:0003231 ! cardiac ventricle development relationship: results_in_morphogenesis_of UBERON:0002082 ! cardiac ventricle created_by: dph creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002081 ! cardiac atrium relationship: part_of GO:0003230 ! cardiac atrium development relationship: results_in_morphogenesis_of UBERON:0002081 ! cardiac atrium created_by: dph creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002081 ! cardiac atrium relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002081 ! cardiac atrium created_by: dph creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002082 ! cardiac ventricle relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002082 ! cardiac ventricle created_by: dph creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002079 ! left cardiac atrium relationship: results_in_morphogenesis_of UBERON:0002079 ! left cardiac atrium created_by: dph creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002078 ! right cardiac atrium relationship: results_in_morphogenesis_of UBERON:0002078 ! right cardiac atrium created_by: dph creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002084 ! heart left ventricle relationship: results_in_morphogenesis_of UBERON:0002084 ! heart left ventricle created_by: dph creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002080 ! heart right ventricle relationship: results_in_morphogenesis_of UBERON:0002080 ! heart right ventricle created_by: dph creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002079 ! left cardiac atrium relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002079 ! left cardiac atrium created_by: dph creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002078 ! right cardiac atrium relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002078 ! right cardiac atrium created_by: dph creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002084 ! heart left ventricle relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002084 ! heart left ventricle created_by: dph creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002080 ! heart right ventricle relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002080 ! heart right ventricle created_by: dph creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0003382 ! cardiac muscle of left ventricle relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis relationship: results_in_morphogenesis_of UBERON:0003382 ! cardiac muscle of left ventricle created_by: dph creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0003381 ! cardiac muscle of right ventricle relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis relationship: results_in_morphogenesis_of UBERON:0003381 ! cardiac muscle of right ventricle created_by: dph creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004126 ! trabecular layer of ventricle relationship: results_in_morphogenesis_of UBERON:0004126 ! trabecular layer of ventricle created_by: dph creation_date: 2009-10-13T10:33:00Z [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0005064 ! left ventricular trabecular myocardium relationship: results_in_morphogenesis_of UBERON:0005064 ! left ventricular trabecular myocardium created_by: dph creation_date: 2009-10-13T10:45:09Z [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0005066 ! right ventricular trabecular myocardium relationship: results_in_morphogenesis_of UBERON:0005066 ! right ventricular trabecular myocardium created_by: dph creation_date: 2009-10-13T10:50:59Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium relationship: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22614 xsd:anyURI created_by: dph creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: results_in_development_of UBERON:0018649 ! cardiac muscle tissue of ventricle created_by: dph creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002081 ! cardiac atrium relationship: results_in_development_of UBERON:0002081 ! cardiac atrium created_by: dph creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002082 ! cardiac ventricle relationship: results_in_development_of UBERON:0002082 ! cardiac ventricle created_by: dph creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002063 ! sinus venosus relationship: results_in_development_of UBERON:0002063 ! sinus venosus created_by: dph creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002063 ! sinus venosus relationship: part_of GO:0003235 ! sinus venosus development relationship: results_in_morphogenesis_of UBERON:0002063 ! sinus venosus created_by: dph creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002063 ! sinus venosus relationship: part_of GO:0003236 ! sinus venosus morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002063 ! sinus venosus created_by: dph creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth created_by: dph creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: results_in_growth_of UBERON:0006966 ! coronary capillary relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development relationship: results_in_growth_of UBERON:0006966 ! coronary capillary created_by: dph creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0002062 ! endocardial cushion relationship: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0002062 ! endocardial cushion created_by: dph creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0003272 ! endocardial cushion formation relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002099 ! cardiac septum relationship: part_of GO:0003205 ! cardiac chamber development relationship: results_in_development_of UBERON:0002099 ! cardiac septum created_by: dph creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002094 ! interventricular septum relationship: part_of GO:0003231 ! cardiac ventricle development relationship: results_in_development_of UBERON:0002094 ! interventricular septum created_by: dph creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002085 ! interatrial septum relationship: part_of GO:0003230 ! cardiac atrium development relationship: results_in_development_of UBERON:0002085 ! interatrial septum created_by: dph creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:2000022 ! cardiac septum cell relationship: part_of GO:0003279 ! cardiac septum development relationship: results_in_acquisition_of_features_of CL:2000022 ! cardiac septum cell created_by: dph creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy created_by: dph creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy created_by: dph creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth created_by: dph creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell relationship: part_of GO:0031018 ! endocrine pancreas development relationship: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell created_by: dph creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell relationship: part_of GO:0031018 ! endocrine pancreas development relationship: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell created_by: dph creation_date: 2009-10-26T09:28:05Z [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell relationship: part_of GO:0031018 ! endocrine pancreas development relationship: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell created_by: dph creation_date: 2009-10-26T09:30:27Z [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell relationship: part_of GO:0031018 ! endocrine pancreas development relationship: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell created_by: dph creation_date: 2009-10-26T09:32:32Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004291 ! heart rudiment relationship: part_of GO:0035050 ! embryonic heart tube development relationship: results_in_development_of UBERON:0004291 ! heart rudiment created_by: dph creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0004291 ! heart rudiment relationship: part_of GO:0003313 ! heart rudiment development relationship: results_in_morphogenesis_of UBERON:0004291 ! heart rudiment created_by: dph creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of_anatomical_entity UBERON:0004291 ! heart rudiment relationship: part_of GO:0003314 ! heart rudiment morphogenesis relationship: results_in_formation_of_anatomical_entity UBERON:0004291 ! heart rudiment created_by: dph creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000171 ! pancreatic A cell relationship: part_of GO:0003310 ! pancreatic A cell differentiation relationship: results_in_development_of CL:0000171 ! pancreatic A cell created_by: dph creation_date: 2009-11-02T08:13:55Z [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000169 ! type B pancreatic cell relationship: part_of GO:0003309 ! type B pancreatic cell differentiation relationship: results_in_development_of CL:0000169 ! type B pancreatic cell created_by: dph creation_date: 2009-11-02T08:20:11Z [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0000173 ! pancreatic D cell relationship: part_of GO:0003311 ! pancreatic D cell differentiation relationship: results_in_development_of CL:0000173 ! pancreatic D cell created_by: dph creation_date: 2009-11-02T08:23:26Z [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development intersection_of: GO:0048468 ! cell development intersection_of: results_in_development_of CL:0002275 ! pancreatic PP cell relationship: part_of GO:0003312 ! pancreatic PP cell differentiation relationship: results_in_development_of CL:0002275 ! pancreatic PP cell created_by: dph creation_date: 2009-11-02T08:25:03Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:35238 ! amino acid zwitterion intersection_of: results_in_transport_across GO:0016020 ! membrane created_by: dph creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004160 ! proepicardium relationship: part_of GO:0003343 ! septum transversum development relationship: results_in_development_of UBERON:0004160 ! proepicardium created_by: dph creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0004161 ! septum transversum relationship: results_in_development_of UBERON:0004161 ! septum transversum created_by: dph creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0002407 ! pericardium relationship: part_of GO:0060039 ! pericardium development relationship: results_in_morphogenesis_of UBERON:0002407 ! pericardium created_by: dph creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0010008 ! cardiac endothelial cell relationship: results_in_acquisition_of_features_of CL:0010008 ! cardiac endothelial cell created_by: dph creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0008025 ! noradrenergic neuron relationship: results_in_acquisition_of_features_of CL:0008025 ! noradrenergic neuron created_by: dph creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: results_in_development_of CL:0008025 ! noradrenergic neuron relationship: part_of GO:0003357 ! noradrenergic neuron differentiation relationship: results_in_development_of CL:0008025 ! noradrenergic neuron created_by: dph creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002298 ! brainstem relationship: results_in_development_of UBERON:0002298 ! brainstem created_by: dph creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation intersection_of: GO:0003357 ! noradrenergic neuron differentiation intersection_of: part_of GO:0003360 ! brainstem development relationship: part_of GO:0003360 ! brainstem development created_by: dph creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003365 name: establishment of cell polarity involved in a