OwnGenome‹ Ruiz family⌕
Personal genome report
Marc Ruiz
41 · male (XY, as declared) · father of Lía · finished 4 Nov

Nothing in what was assessed reaches take to a doctor. Two results are for whoever prescribes: clopidogrel would not work well, and simvastatin should stay at 20 mg or less. Three point at the heart together, and a blood Lp(a) test is the one thing worth doing.

✓Data: 29.1× · identity confirmed · 1 step not assessed
1

To act on

Is there anything to take to a doctor?
No finding in what these steps assessed.They look at known disease changes, cancer genes, the 84 secondary-finding genes, repeats and large deletions. They do not see changes ClinVar does not list, 14 hard-to-read genes, or the MUC1 kidney gene, which was not assessed (section 6).
2

Medicines

Show this list to a doctor or pharmacist.
Marc's medicines list6 drugs
ClopidogrelAvoid
Use prasugrel or ticagrelor if suitable.
CYP2C19 poor metaboliser (*2/*2) · strong evidence
Simvastatin20 mg max
Or another statin: rosuvastatin, pravastatin.
SLCO1B1 decreased function · strong
Atorvastatin40 mg max
Higher only with monitoring.
SLCO1B1 · moderate
Citalopram, escitalopramHalf dose
Start at 50%, raise slowly, or choose another.
CYP2C19 · moderate
VoriconazoleAvoid
Choose an antifungal not using CYP2C19.
CYP2C19 · moderate
Omeprazole, pantoprazoleConsider
Standard dose; lower it for long-term use.
CYP2C19 · optional

CaveatA research tool; confirm with a certified test before a prescription changes.

Open full screen for the pharmacist
3

The heart, together

Three results that point the same way.
Worth a look

Genetically high Lp(a) likely

Few copies of a repeat in the LPA gene go with a high Lp(a), a blood fat that raises the risk of heart attack.

rs10455872 · risk allelers3798220 · none

Do: ask for one blood Lp(a) test. It is what counts.

Information

Coronary artery disease score: 88th percentile

Higher than 88 of 100 people of similar (European) ancestry. Not a probability: measured LDL, blood pressure and Lp(a) say far more.

Prescriber

If a statin starts, choose it with SLCO1B1 in mind

Simvastatin 20 mg or less, or rosuvastatin or pravastatin. See the list

4

Worth a look

What deserves a conversation, but is not a diagnosis?

Worth a look

HLA-B*27 present

About 8% of Europeans carry it; most never develop spondylitis. None of the four listed drug-reaction alleles is present.

CaveatTyping from short reads is approximate.

5

For your family

What could Marc pass on to a child?

Family planning

Cystic fibrosis carrier, shared with Elena

CFTR p.Gly542Ter. Both partners carry one: 1 in 4 per pregnancy. Lía did not inherit Marc's copy.

The couple screen →
Family planning

Phenylketonuria carrier

PAH p.Arg408Trp. Elena carries no PAH change the screen sees. Lía did not inherit it.

6

Can I trust this?

About the data, not about Marc.
Depth29.1×
At 10×97.2%
Other DNA0.6%
Sex checkXY ✓
▲ Not assessed
MUC1 kidney gene. The repeat had 41× depth; this step needs 100×. Read it as not checked, not as clear. Rerun with deeper data
7

Explore

Everything else we uncovered.
OriginsPaternal line R-DF27 · maternal J1c2 · Neanderthal 2.1%+
Scores and traits6 scores · blood group O, RhD+ · telomeres+
Repeats6 loci sized, all below their expansion line+
Assessed, no findingBlood clones, mosaic changes, viral DNA, structural+
What it cannot see6 limits for everyone, 14 hard genes+
Sources and filesClinVar 2026-11-06 is out; this used 2026-10-02+
OwnGenome 1.0.0 · a research pipeline, not a clinical test · RUIZ-MARC · synthetic data