Lysine catabolism - imported from: Reactome
type: Ontology
modelstate: development
provided by: https://reactome.org
comment: For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl
comment: http://www.reactome.org
comment: Automated change 2026-01-08: GO:0006554 replaced by GO:0019477
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

OA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113587
type: NamedIndividual
type: CHEBI_16452
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2OG
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113594
type: NamedIndividual
type: CHEBI_16810
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

Glu
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113552
type: NamedIndividual
type: CHEBI_29985
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

L-Asp
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113553
type: NamedIndividual
type: CHEBI_29991
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

ev w id R-HSA-70613 RO 0002233 CHEBI 16452 R-HSA-70613 Reactome R-HSA-70613
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70613

ev w id R-HSA-70613 RO 0002233 CHEBI 29985 R-HSA-70613 Reactome R-HSA-70613
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70613

ev w id R-HSA-70613 RO 0002234 CHEBI 16810 R-HSA-70613 Reactome R-HSA-70613
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70613

ev w id R-HSA-70613 RO 0002234 CHEBI 29991 R-HSA-70613 Reactome R-HSA-70613
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70613

ev w id R-HSA-70613 RO 0002333 R-HSA-70594 R-HSA-70613 controller Reactome R-HSA-70613
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70613

GOT2 dimer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-70594
type: NamedIndividual
type: REACTO R-HSA-70594
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

GOT2 transaminates oxaloacetate and glutamate
x: 534.147600230716
y: 1011.9744960200544
RO_0002333: GOT2 dimer
provided by: https://reactome.org
BFO_0000066: reaction R-HSA-70613 location lociGO 0005759
RO_0002233: OA
RO_0002233: Glu
RO_0002234: 2OG
RO_0002234: L-Asp
RO_0002411: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
has db xref: Reactome:R-HSA-70613
type: NamedIndividual
type: GO_0004069
comment: reaction from external pathway R-HSA-70263
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

reaction R-HSA-70613 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

CO2
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29376
type: NamedIndividual
type: CHEBI_16526
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

crotonyl-CoA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-71045
type: NamedIndividual
type: CHEBI_57332
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

GL-CoA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-70955
type: NamedIndividual
type: CHEBI_57378
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

FAD
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113596
type: NamedIndividual
type: CHEBI_57692
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

FADH2
provided by: https://reactome.org
has db xref: Reactome:R-ALL-31649
type: NamedIndividual
type: CHEBI_58307
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

ev w id R-HSA-71046 RO 0002233 CHEBI 57378 R-HSA-71046 Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002233 CHEBI 57378 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 RO 0002233 CHEBI 57692 R-HSA-71046 Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002233 CHEBI 57692 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 RO 0002234 CHEBI 16526 R-HSA-71046 Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002234 CHEBI 16526 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 RO 0002234 CHEBI 57332 R-HSA-71046 Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002234 CHEBI 57332 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 RO 0002234 CHEBI 58307 R-HSA-71046 Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002234 CHEBI 58307 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 RO 0002333 R-HSA-71040 R-HSA-71046 controller Reactome R-HSA-71046
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71046

ev w id R-HSA-71046 RO 0002333 R-HSA-71040 R-HSA-71046 controller Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

GCDH tetramer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-71040
type: NamedIndividual
type: REACTO R-HSA-71040
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
x: 1698.0399686010967
y: 1188.008594837919
RO_0002333: GCDH tetramer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-71046 location lociGO 0005759
RO_0002233: GL-CoA
RO_0002233: FAD
RO_0002234: CO2
RO_0002234: crotonyl-CoA
RO_0002234: FADH2
has db xref: Reactome:R-HSA-71046
type: NamedIndividual
type: GO_0004361
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

reaction R-HSA-71046 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

H2O
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113521
type: NamedIndividual
type: CHEBI_15377
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H2O
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113521
type: NamedIndividual
type: CHEBI_15377
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H2O
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113521
type: NamedIndividual
type: CHEBI_15377
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H2O
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113521
type: NamedIndividual
type: CHEBI_15377
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H+
provided by: https://reactome.org
has db xref: Reactome:R-ALL-193465
type: NamedIndividual
type: CHEBI_15378
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H+
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113529
type: NamedIndividual
type: CHEBI_15378
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H+
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113529
type: NamedIndividual
type: CHEBI_15378
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H+
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113529
type: NamedIndividual
type: CHEBI_15378
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

O2
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113535
type: NamedIndividual
type: CHEBI_15379
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

aKADA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-70951
type: NamedIndividual
type: CHEBI_15753
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

aKADA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-70951
type: NamedIndividual
type: CHEBI_15753
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

aKADA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-70951
type: NamedIndividual
type: CHEBI_15753
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NH3
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5693978
type: NamedIndividual
type: CHEBI_16134
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

P2C
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5693311
type: NamedIndividual
type: CHEBI_16187
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

H2O2
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113575
type: NamedIndividual
type: CHEBI_16240
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

TPNH
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113602
type: NamedIndividual
type: CHEBI_16474
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

TPNH
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113600
type: NamedIndividual
type: CHEBI_16474
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

CO2
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29376
type: NamedIndividual
type: CHEBI_16526
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

5PHL
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5696409
type: NamedIndividual
type: CHEBI_16752
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

5PHL
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5696409
type: NamedIndividual
type: CHEBI_16752
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2OG
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113594
type: NamedIndividual
type: CHEBI_16810
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2OG
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113594
type: NamedIndividual
type: CHEBI_16810
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2OG
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113594
type: NamedIndividual
type: CHEBI_16810
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

SACN
provided by: https://reactome.org
has db xref: Reactome:R-ALL-30176
type: NamedIndividual
type: CHEBI_16927
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

SACN
provided by: https://reactome.org
has db xref: Reactome:R-ALL-30176
type: NamedIndividual
type: CHEBI_16927
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

TPN
provided by: https://reactome.org
has db xref: Reactome:R-ALL-389556
type: NamedIndividual
type: CHEBI_18009
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

TPN
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113563
type: NamedIndividual
type: CHEBI_18009
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

Glu
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113552
type: NamedIndividual
type: CHEBI_29985
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

Glu
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113552
type: NamedIndividual
type: CHEBI_29985
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

Glu
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113552
type: NamedIndividual
type: CHEBI_29985
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

L-Lys
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29444
type: NamedIndividual
type: CHEBI_32551
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

GTP
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113573
type: NamedIndividual
type: CHEBI_37565
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

Pi
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113548
type: NamedIndividual
type: CHEBI_43474
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

CoA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29374
type: NamedIndividual
type: CHEBI_57287
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

GL-CoA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-70955
type: NamedIndividual
type: CHEBI_57378
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NAD
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113526
type: NamedIndividual
type: CHEBI_57540
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NAD
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113526
type: NamedIndividual
type: CHEBI_57540
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NAD
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113526
type: NamedIndividual
type: CHEBI_57540
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NADH
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29362
type: NamedIndividual
type: CHEBI_57945
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NADH
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29362
type: NamedIndividual
type: CHEBI_57945
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

NADH
provided by: https://reactome.org
has db xref: Reactome:R-ALL-29362
type: NamedIndividual
type: CHEBI_57945
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

GDP
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113525
type: NamedIndividual
type: CHEBI_58189
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMAS
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113556
type: NamedIndividual
type: CHEBI_58321
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMAS
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113556
type: NamedIndividual
type: CHEBI_58321
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMAS
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has db xref: Reactome:R-ALL-113556
type: NamedIndividual
type: CHEBI_58321
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMAS
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113556
type: NamedIndividual
type: CHEBI_58321
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-508531
type: NamedIndividual
type: CHEBI_58672
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-508531
type: NamedIndividual
type: CHEBI_58672
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note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

2AMA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-508531
type: NamedIndividual
type: CHEBI_58672
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

P6C
provided by: https://reactome.org
has db xref: Reactome:R-ALL-6783877
type: NamedIndividual
type: CHEBI_58769
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

P6C
provided by: https://reactome.org
has db xref: Reactome:R-ALL-6783877
type: NamedIndividual
type: CHEBI_58769
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

5HLYS
provided by: https://reactome.org
has db xref: Reactome:R-ALL-6788606
type: NamedIndividual
type: CHEBI_60175
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

PPCA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5693325
type: NamedIndividual
type: CHEBI_61185
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

PPCA
provided by: https://reactome.org
has db xref: Reactome:R-ALL-5693325
type: NamedIndividual
type: CHEBI_61185
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: GOC:reactome_curators
date: 2023-06-21

GO 0005829 R-HSA-372480
x: 578.6745581928288
y: 1246.9570665990582
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type: NamedIndividual
type: GO_0005829
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 BFO 0000066 reaction R-HSA-372480 location lociGO 0005743 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 RO 0002333 R-HSA-372474 R-HSA-372480 controller Reactome R-HSA-372480
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-372480

ev w id R-HSA-372480 RO 0002333 R-HSA-372474 R-HSA-372480 controller Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

GO 0005759 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

GO 0005829 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 RO 0002411 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 RO 0002411 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 RO 0004009 transported CHEBI 15753 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-372480 RO 0004009 transported CHEBI 16810 R-HSA-372480 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-508561 BFO 0000066 reaction R-HSA-508561 location lociGO 0005759 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-508561 RO 0002233 CHEBI 15753 R-HSA-508561 Reactome R-HSA-508561
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-508561

ev w id R-HSA-508561 RO 0002233 CHEBI 15753 R-HSA-508561 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-508561 RO 0002233 CHEBI 29985 R-HSA-508561 Reactome R-HSA-508561
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-508561

ev w id R-HSA-508561 RO 0002233 CHEBI 29985 R-HSA-508561 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-508561 RO 0002234 CHEBI 16810 R-HSA-508561 Reactome R-HSA-508561
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-508561

ev w id R-HSA-508561 RO 0002234 CHEBI 16810 R-HSA-508561 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-508561 RO 0002234 CHEBI 58672 R-HSA-508561 Reactome R-HSA-508561
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-508561

ev w id R-HSA-508561 RO 0002234 CHEBI 58672 R-HSA-508561 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
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ev w id R-HSA-508561 RO 0002333 R-HSA-508545 R-HSA-508561 controller Reactome R-HSA-508561
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-508561

ev w id R-HSA-508561 RO 0002333 R-HSA-508545 R-HSA-508561 controller Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 BFO 0000066 reaction R-HSA-5693347 location lociGO 0005782 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002233 CHEBI 15378 R-HSA-5693347 Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002233 CHEBI 15378 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002233 CHEBI 16187 R-HSA-5693347 Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002233 CHEBI 16187 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002233 CHEBI 16474 R-HSA-5693347 Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002233 CHEBI 16474 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002234 CHEBI 18009 R-HSA-5693347 Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002234 CHEBI 18009 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002234 CHEBI 61185 R-HSA-5693347 Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002234 CHEBI 61185 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002333 R-HSA-5693333 R-HSA-5693347 controller Reactome R-HSA-5693347
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5693347

ev w id R-HSA-5693347 RO 0002333 R-HSA-5693333 R-HSA-5693347 controller Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5693347 RO 0002413 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 BFO 0000066 reaction R-HSA-5696408 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002233 CHEBI 15377 R-HSA-5696408 Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002233 CHEBI 15377 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002233 CHEBI 16752 R-HSA-5696408 Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002233 CHEBI 16752 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002234 CHEBI 16134 R-HSA-5696408 Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002234 CHEBI 16134 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002234 CHEBI 43474 R-HSA-5696408 Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002234 CHEBI 43474 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002234 CHEBI 58321 R-HSA-5696408 Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002234 CHEBI 58321 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002333 R-HSA-5696429 R-HSA-5696408 controller Reactome R-HSA-5696408
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-5696408

ev w id R-HSA-5696408 RO 0002333 R-HSA-5696429 R-HSA-5696408 controller Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-5696408 RO 0002413 R-HSA-70941 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-6783880 BFO 0000066 reaction R-HSA-6783880 location lociGO 0005782 Reactome R-HSA-71064
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type: NamedIndividual
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date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-6783880 RO 0002233 CHEBI 15379 R-HSA-6783880 Reactome R-HSA-6783880
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-6783880

ev w id R-HSA-6783880 RO 0002233 CHEBI 15379 R-HSA-6783880 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-6783880 RO 0002233 CHEBI 61185 R-HSA-6783880 Reactome R-HSA-6783880
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type: NamedIndividual
type: ECO_0000313
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date: 2023-06-21
source: Reactome:R-HSA-6783880

ev w id R-HSA-6783880 RO 0002233 CHEBI 61185 R-HSA-6783880 Reactome R-HSA-71064
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type: NamedIndividual
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ev w id R-HSA-6783880 RO 0002234 CHEBI 16240 R-HSA-6783880 Reactome R-HSA-6783880
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type: NamedIndividual
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ev w id R-HSA-6783880 RO 0002234 CHEBI 16240 R-HSA-6783880 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
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source: Reactome:R-HSA-71064

ev w id R-HSA-6783880 RO 0002234 CHEBI 58769 R-HSA-6783880 Reactome R-HSA-6783880
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type: NamedIndividual
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source: Reactome:R-HSA-6783880

ev w id R-HSA-6783880 RO 0002234 CHEBI 58769 R-HSA-6783880 Reactome R-HSA-71064
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type: NamedIndividual
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ev w id R-HSA-6783880 RO 0002333 R-HSA-452911 R-HSA-6783880 controller Reactome R-HSA-6783880
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type: NamedIndividual
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ev w id R-HSA-6783880 RO 0002333 R-HSA-452911 R-HSA-6783880 controller Reactome R-HSA-71064
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type: NamedIndividual
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source: Reactome:R-HSA-71064

ev w id R-HSA-6783880 RO 0002413 R-HSA-6783883 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
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source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-6783883 RO 0002233 CHEBI 58769 R-HSA-6783883 Reactome R-HSA-6783883
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
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source: Reactome:R-HSA-6783883

ev w id R-HSA-6783883 RO 0002233 CHEBI 58769 R-HSA-6783883 Reactome R-HSA-71064
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type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-6783883 RO 0002234 CHEBI 58321 R-HSA-6783883 Reactome R-HSA-6783883
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type: NamedIndividual
type: ECO_0000313
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type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-70952 RO 0002234 CHEBI 15753 R-HSA-70952 Reactome R-HSA-70952
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70952

ev w id R-HSA-70952 RO 0002234 CHEBI 15753 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-70952 RO 0002234 CHEBI 29985 R-HSA-70952 Reactome R-HSA-70952
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70952

ev w id R-HSA-70952 RO 0002234 CHEBI 29985 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-70952 RO 0002333 R-HSA-508545 R-HSA-70952 controller Reactome R-HSA-70952
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-70952

ev w id R-HSA-70952 RO 0002333 R-HSA-508545 R-HSA-70952 controller Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 BFO 0000066 reaction R-HSA-71037 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002233 CHEBI 15753 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002233 CHEBI 15753 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002233 CHEBI 57287 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002233 CHEBI 57287 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002233 CHEBI 57540 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002233 CHEBI 57540 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002234 CHEBI 16526 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002234 CHEBI 16526 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002234 CHEBI 57378 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002234 CHEBI 57378 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002234 CHEBI 57945 R-HSA-71037 Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002234 CHEBI 57945 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002333 R-HSA-69996 R-HSA-71037 controller Reactome R-HSA-71037
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71037

ev w id R-HSA-71037 RO 0002333 R-HSA-69996 R-HSA-71037 controller Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71037 RO 0002413 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000363
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

ev w id R-HSA-71046 BFO 0000066 reaction R-HSA-71046 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
type: NamedIndividual
type: ECO_0000313
contributor: GOC:reactome_curators
date: 2023-06-21
source: Reactome:R-HSA-71064

SLC25A21
provided by: https://reactome.org
has db xref: Reactome:R-HSA-372474
type: NamedIndividual
type: REACTO R-HSA-372474
comment: located_in mitochondrial inner membrane
note: org.biopax.paxtools.model.level3.Protein
contributor: GOC:reactome_curators
date: 2023-06-21

Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
x: 867.4761029365933
y: 1024.4684764796743
RO_0002333: SLC25A21
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-372480 location lociGO 0005743
RO_0002411: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
RO_0002411: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
has db xref: Reactome:R-HSA-372480
RO_0004009: aKADA
RO_0004009: 2OG
RO_0002338: GO 0005759 R-HSA-372480
RO_0002339: GO 0005829 R-HSA-372480
type: NamedIndividual
type: GO_0015139
comment: Transporter Rule. This reaction represents the activity of transporting
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

PIPOX
provided by: https://reactome.org
has db xref: Reactome:R-HSA-452911
type: NamedIndividual
type: REACTO R-HSA-452911
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.Protein
contributor: GOC:reactome_curators
date: 2023-06-21

AADAT dimer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-508545
type: NamedIndividual
type: REACTO R-HSA-508545
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

AADAT dimer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-508545
type: NamedIndividual
type: REACTO R-HSA-508545
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
x: 1609.960515474995
y: 887.1266615858128
RO_0002333: AADAT dimer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-508561 location lociGO 0005759
RO_0002233: aKADA
RO_0002233: Glu
RO_0002234: 2OG
RO_0002234: 2AMA
has db xref: Reactome:R-HSA-508561
type: NamedIndividual
type: GO_0047536
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

ALDH7A1 tetramer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-508564
type: NamedIndividual
type: REACTO R-HSA-508564
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

CRYM
provided by: https://reactome.org
has db xref: Reactome:R-HSA-5693333
type: NamedIndividual
type: REACTO R-HSA-5693333
comment: located_in peroxisomal matrix
note: org.biopax.paxtools.model.level3.Protein
contributor: GOC:reactome_curators
date: 2023-06-21

CRYM reduces P2C to PPCA
x: 89.68853101851097
y: 341.7933549915956
RO_0002333: CRYM
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-5693347 location lociGO 0005782
RO_0002233: H+
RO_0002233: P2C
RO_0002233: TPNH
RO_0002234: TPN
RO_0002234: PPCA
RO_0002413: PIPOX oxidises PPCA to P6C
has db xref: Reactome:R-HSA-5693347
type: NamedIndividual
type: GO_0047127
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
x: 150.90573449074452
y: 590.2779821981417
RO_0002333: PXLP-K278-PHYKPL tetramer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-5696408 location lociGO 0005759
RO_0002233: H2O
RO_0002233: 5PHL
RO_0002234: NH3
RO_0002234: Pi
RO_0002234: 2AMAS
RO_0002413: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
has db xref: Reactome:R-HSA-5696408
type: NamedIndividual
type: GO_0016829
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

PXLP-K278-PHYKPL tetramer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-5696429
type: NamedIndividual
type: REACTO R-HSA-5696429
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

PIPOX oxidises PPCA to P6C
x: 371.59857892813073
y: 464.40333060254295
RO_0002333: PIPOX
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-6783880 location lociGO 0005782
RO_0002233: O2
RO_0002233: PPCA
RO_0002234: H2O2
RO_0002234: P6C
RO_0002413: P6C transforms to 2AMAS
has db xref: Reactome:R-HSA-6783880
type: NamedIndividual
type: GO_0050031
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

P6C transforms to 2AMAS
x: 662.7388499365004
y: 480.0708046304767
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
RO_0002233: P6C
RO_0002234: 2AMAS
RO_0002413: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
has db xref: Reactome:R-HSA-6783883
type: NamedIndividual
type: molecular event
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

HYKK
provided by: https://reactome.org
has db xref: Reactome:R-HSA-6788610
type: NamedIndividual
type: REACTO R-HSA-6788610
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Protein
contributor: GOC:reactome_curators
date: 2023-06-21

HYKK phosphorylates 5HLYS
x: 114.20064387155644
y: 144.2801475077624
RO_0002333: HYKK
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-6788611 location lociGO 0005759
RO_0002233: GTP
RO_0002233: 5HLYS
RO_0002234: 5PHL
RO_0002234: GDP
has db xref: Reactome:R-HSA-6788611
type: NamedIndividual
type: GO_0047992
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

lipo-aKGDH
provided by: https://reactome.org
has db xref: Reactome:R-HSA-69996
type: NamedIndividual
type: REACTO R-HSA-69996
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

AASS tetramer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-70925
type: NamedIndividual
type: REACTO R-HSA-70925
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

AASS tetramer
provided by: https://reactome.org
has db xref: Reactome:R-HSA-70925
type: NamedIndividual
type: REACTO R-HSA-70925
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.Complex
contributor: GOC:reactome_curators
date: 2023-06-21

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
x: 190.59836393062415
y: 789.0478791286594
RO_0002333: AASS tetramer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-70938 location lociGO 0005759
RO_0002233: H+
RO_0002233: TPNH
RO_0002233: 2OG
RO_0002233: L-Lys
RO_0002234: H2O
RO_0002234: SACN
RO_0002234: TPN
RO_0002413: AASS tetramer oxidises SACN to 2AMAS
has db xref: Reactome:R-HSA-70938
type: NamedIndividual
type: GO_0047130
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

AASS tetramer oxidises SACN to 2AMAS
x: 506.68041905216376
y: 781.2714709394576
RO_0002333: AASS tetramer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-70940 location lociGO 0005759
RO_0002233: H2O
RO_0002233: SACN
RO_0002233: NAD
RO_0002234: H+
RO_0002234: Glu
RO_0002234: NADH
RO_0002234: 2AMAS
RO_0002413: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
has db xref: Reactome:R-HSA-70940
type: NamedIndividual
type: GO_0047131
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
x: 942.0194784061517
y: 604.1608456850593
RO_0002333: ALDH7A1 tetramer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-70941 location lociGO 0005759
RO_0002233: H2O
RO_0002233: NAD
RO_0002233: 2AMAS
RO_0002234: H+
RO_0002234: NADH
RO_0002234: 2AMA
RO_0002413: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
has db xref: Reactome:R-HSA-70941
type: NamedIndividual
type: GO_0004043
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
x: 1329.2428203986199
y: 607.3804686207
RO_0002333: AADAT dimer
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-70952 location lociGO 0005759
RO_0002233: 2OG
RO_0002233: 2AMA
RO_0002234: aKADA
RO_0002234: Glu
has db xref: Reactome:R-HSA-70952
type: NamedIndividual
type: GO_0047536
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
x: 1407.066226197424
y: 1107.665645238736
RO_0002333: lipo-aKGDH
provided by: https://reactome.org
BFO_0000050: Lysine catabolism
BFO_0000066: reaction R-HSA-71037 location lociGO 0005759
RO_0002233: aKADA
RO_0002233: CoA
RO_0002233: NAD
RO_0002234: CO2
RO_0002234: GL-CoA
RO_0002234: NADH
RO_0002413: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
has db xref: Reactome:R-HSA-71037
type: NamedIndividual
type: GO_0034602
note: org.biopax.paxtools.model.level3.BiochemicalReaction
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

Lysine catabolism
x: 629.129775658854
y: 100.97655319791733
provided by: https://reactome.org
has db xref: R-HSA-71064
narrower: R-HSA-71291
type: NamedIndividual
type: GO_0019477
comment: Automated change 2026-01-08: GO:0006554 replaced by GO:0019477
comment: In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).
note: org.biopax.paxtools.model.level3.Pathway
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
contributor: Edited: D'Eustachio, P, 0000-00-00 00:00:00
contributor: Authored: D'Eustachio, P, 2003-06-24 00:00:00
date: 2026-02-03

reaction R-HSA-372480 location lociGO 0005743
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005743
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-508561 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-5693347 location lociGO 0005782
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005782
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-5696408 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-6783880 location lociGO 0005782
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005782
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-6788611 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-70938 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-70940 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-70941 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-70952 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

reaction R-HSA-71037 location lociGO 0005759
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: GOC:reactome_curators
date: 2023-06-21

GO 0005759 R-HSA-372480
x: 1260.1077749917097
y: 1290.059030903668
provided by: https://reactome.org
type: NamedIndividual
type: GO_0005759
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

aKADA
x: 794.9499096317006
y: 1353.7724376813717
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113577
has db xref: Reactome:R-ALL-70951
type: NamedIndividual
type: CHEBI_15753
comment: located_in cytosol
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

2OG
x: 1053.8519066909041
y: 1306.161394185008
provided by: https://reactome.org
has db xref: Reactome:R-ALL-113594
has db xref: Reactome:R-ALL-29406
type: NamedIndividual
type: CHEBI_16810
comment: located_in cytosol
comment: located_in mitochondrial matrix
note: org.biopax.paxtools.model.level3.SmallMolecule
contributor: https://orcid.org/0000-0001-7476-6306
contributor: GOC:reactome_curators
date: 2026-02-03

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 BFO 0000066 reaction R-HSA-71037 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: reaction R-HSA-71037 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 15753 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 15753 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: aKADA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 57287 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 57287 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: CoA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 57540 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002233 CHEBI 57540 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: NAD
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 16526 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 16526 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: CO2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 57378 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 57378 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: GL-CoA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 57945 R-HSA-71037 Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002234 CHEBI 57945 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: NADH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002333 R-HSA-69996 R-HSA-71037 controller Reactome R-HSA-71037
evidence: ev w id R-HSA-71037 RO 0002333 R-HSA-69996 R-HSA-71037 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: lipo-aKGDH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71037 RO 0002413 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
annotated target: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+' 'null' 'glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 BFO 0000066 reaction R-HSA-508561 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: reaction R-HSA-508561 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 BFO 0000066 reaction R-HSA-71046 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: reaction R-HSA-71046 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002233 CHEBI 57378 R-HSA-71046 Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002233 CHEBI 57378 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: GL-CoA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002233 CHEBI 57692 R-HSA-71046 Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002233 CHEBI 57692 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: FAD
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 16526 R-HSA-71046 Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 16526 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: CO2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 57332 R-HSA-71046 Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 57332 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: crotonyl-CoA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 58307 R-HSA-71046 Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002234 CHEBI 58307 R-HSA-71046 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: FADH2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-71046 RO 0002333 R-HSA-71040 R-HSA-71046 controller Reactome R-HSA-71046
evidence: ev w id R-HSA-71046 RO 0002333 R-HSA-71040 R-HSA-71046 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
annotated target: GCDH tetramer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 RO 0002233 CHEBI 15753 R-HSA-508561 Reactome R-HSA-508561
evidence: ev w id R-HSA-508561 RO 0002233 CHEBI 15753 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: aKADA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 RO 0002233 CHEBI 29985 R-HSA-508561 Reactome R-HSA-508561
evidence: ev w id R-HSA-508561 RO 0002233 CHEBI 29985 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: Glu
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 RO 0002234 CHEBI 16810 R-HSA-508561 Reactome R-HSA-508561
evidence: ev w id R-HSA-508561 RO 0002234 CHEBI 16810 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: 2OG
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 RO 0002234 CHEBI 58672 R-HSA-508561 Reactome R-HSA-508561
evidence: ev w id R-HSA-508561 RO 0002234 CHEBI 58672 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: 2AMA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-508561 RO 0002333 R-HSA-508545 R-HSA-508561 controller Reactome R-HSA-508561
evidence: ev w id R-HSA-508561 RO 0002333 R-HSA-508545 R-HSA-508561 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
annotated target: AADAT dimer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: CRYM reduces P2C to PPCA
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 BFO 0000066 reaction R-HSA-5693347 location lociGO 0005782 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: CRYM reduces P2C to PPCA
annotated target: reaction R-HSA-5693347 location lociGO 0005782
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 15378 R-HSA-5693347 Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 15378 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: CRYM reduces P2C to PPCA
annotated target: H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 BFO 0000066 reaction R-HSA-372480 location lociGO 0005743 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: reaction R-HSA-372480 location lociGO 0005743
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 16187 R-HSA-5693347 Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 16187 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: CRYM reduces P2C to PPCA
annotated target: P2C
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 16474 R-HSA-5693347 Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002233 CHEBI 16474 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: CRYM reduces P2C to PPCA
annotated target: TPNH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002234 CHEBI 18009 R-HSA-5693347 Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002234 CHEBI 18009 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: CRYM reduces P2C to PPCA
annotated target: TPN
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002234 CHEBI 61185 R-HSA-5693347 Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002234 CHEBI 61185 R-HSA-5693347 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: CRYM reduces P2C to PPCA
annotated target: PPCA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002333 R-HSA-5693333 R-HSA-5693347 controller Reactome R-HSA-5693347
evidence: ev w id R-HSA-5693347 RO 0002333 R-HSA-5693333 R-HSA-5693347 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: CRYM reduces P2C to PPCA
annotated target: CRYM
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5693347 RO 0002413 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: CRYM reduces P2C to PPCA
annotated target: PIPOX oxidises PPCA to P6C
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'CRYM reduces P2C to PPCA' 'null' 'PIPOX oxidises PPCA to P6C' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 BFO 0000066 reaction R-HSA-5696408 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: reaction R-HSA-5696408 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002233 CHEBI 15377 R-HSA-5696408 Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002233 CHEBI 15377 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: H2O
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002233 CHEBI 16752 R-HSA-5696408 Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002233 CHEBI 16752 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: 5PHL
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 RO 0002333 R-HSA-372474 R-HSA-372480 controller Reactome R-HSA-372480
evidence: ev w id R-HSA-372480 RO 0002333 R-HSA-372474 R-HSA-372480 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: SLC25A21
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 16134 R-HSA-5696408 Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 16134 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: NH3
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 43474 R-HSA-5696408 Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 43474 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: Pi
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 58321 R-HSA-5696408 Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002234 CHEBI 58321 R-HSA-5696408 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002333 R-HSA-5696429 R-HSA-5696408 controller Reactome R-HSA-5696408
evidence: ev w id R-HSA-5696408 RO 0002333 R-HSA-5696429 R-HSA-5696408 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: PXLP-K278-PHYKPL tetramer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-5696408 RO 0002413 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
annotated target: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'PXLP-K278-PHYKPL tetramer hydrolyses 5PHL' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: PIPOX oxidises PPCA to P6C
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 BFO 0000066 reaction R-HSA-6783880 location lociGO 0005782 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: PIPOX oxidises PPCA to P6C
annotated target: reaction R-HSA-6783880 location lociGO 0005782
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002233 CHEBI 15379 R-HSA-6783880 Reactome R-HSA-6783880
evidence: ev w id R-HSA-6783880 RO 0002233 CHEBI 15379 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: PIPOX oxidises PPCA to P6C
annotated target: O2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002233 CHEBI 61185 R-HSA-6783880 Reactome R-HSA-6783880
evidence: ev w id R-HSA-6783880 RO 0002233 CHEBI 61185 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: PIPOX oxidises PPCA to P6C
annotated target: PPCA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002234 CHEBI 16240 R-HSA-6783880 Reactome R-HSA-6783880
evidence: ev w id R-HSA-6783880 RO 0002234 CHEBI 16240 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: PIPOX oxidises PPCA to P6C
annotated target: H2O2
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: GO 0005759 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002338
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: GO 0005759 R-HSA-372480
comment: This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002234 CHEBI 58769 R-HSA-6783880 Reactome R-HSA-6783880
evidence: ev w id R-HSA-6783880 RO 0002234 CHEBI 58769 R-HSA-6783880 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: PIPOX oxidises PPCA to P6C
annotated target: P6C
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002333 R-HSA-452911 R-HSA-6783880 controller Reactome R-HSA-6783880
evidence: ev w id R-HSA-6783880 RO 0002333 R-HSA-452911 R-HSA-6783880 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: PIPOX oxidises PPCA to P6C
annotated target: PIPOX
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783880 RO 0002413 R-HSA-6783883 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: PIPOX oxidises PPCA to P6C
annotated target: P6C transforms to 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'PIPOX oxidises PPCA to P6C' 'null' 'P6C transforms to 2AMAS' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: P6C transforms to 2AMAS
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783883 RO 0002233 CHEBI 58769 R-HSA-6783883 Reactome R-HSA-6783883
evidence: ev w id R-HSA-6783883 RO 0002233 CHEBI 58769 R-HSA-6783883 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: P6C transforms to 2AMAS
annotated target: P6C
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783883 RO 0002234 CHEBI 58321 R-HSA-6783883 Reactome R-HSA-6783883
evidence: ev w id R-HSA-6783883 RO 0002234 CHEBI 58321 R-HSA-6783883 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: P6C transforms to 2AMAS
annotated target: 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6783883 RO 0002413 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: P6C transforms to 2AMAS
annotated target: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'P6C transforms to 2AMAS' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: HYKK phosphorylates 5HLYS
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 BFO 0000066 reaction R-HSA-6788611 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: HYKK phosphorylates 5HLYS
annotated target: reaction R-HSA-6788611 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 RO 0002233 CHEBI 37565 R-HSA-6788611 Reactome R-HSA-6788611
evidence: ev w id R-HSA-6788611 RO 0002233 CHEBI 37565 R-HSA-6788611 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: HYKK phosphorylates 5HLYS
annotated target: GTP
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: GO 0005829 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002339
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: GO 0005829 R-HSA-372480
comment: This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 RO 0002233 CHEBI 60175 R-HSA-6788611 Reactome R-HSA-6788611
evidence: ev w id R-HSA-6788611 RO 0002233 CHEBI 60175 R-HSA-6788611 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: HYKK phosphorylates 5HLYS
annotated target: 5HLYS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 RO 0002234 CHEBI 16752 R-HSA-6788611 Reactome R-HSA-6788611
evidence: ev w id R-HSA-6788611 RO 0002234 CHEBI 16752 R-HSA-6788611 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: HYKK phosphorylates 5HLYS
annotated target: 5PHL
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 RO 0002234 CHEBI 58189 R-HSA-6788611 Reactome R-HSA-6788611
evidence: ev w id R-HSA-6788611 RO 0002234 CHEBI 58189 R-HSA-6788611 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: HYKK phosphorylates 5HLYS
annotated target: GDP
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-6788611 RO 0002333 R-HSA-6788610 R-HSA-6788611 controller Reactome R-HSA-6788611
evidence: ev w id R-HSA-6788611 RO 0002333 R-HSA-6788610 R-HSA-6788611 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: HYKK phosphorylates 5HLYS
annotated target: HYKK
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 BFO 0000066 reaction R-HSA-70613 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: reaction R-HSA-70613 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002233 CHEBI 16452 R-HSA-70613 Reactome R-HSA-70613
evidence: ev w id R-HSA-70613 RO 0002233 CHEBI 16452 R-HSA-70613 Reactome R-HSA-70263
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: OA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002233 CHEBI 29985 R-HSA-70613 Reactome R-HSA-70613
evidence: ev w id R-HSA-70613 RO 0002233 CHEBI 29985 R-HSA-70613 Reactome R-HSA-70263
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: Glu
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002234 CHEBI 16810 R-HSA-70613 Reactome R-HSA-70613
evidence: ev w id R-HSA-70613 RO 0002234 CHEBI 16810 R-HSA-70613 Reactome R-HSA-70263
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: 2OG
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002234 CHEBI 29991 R-HSA-70613 Reactome R-HSA-70613
evidence: ev w id R-HSA-70613 RO 0002234 CHEBI 29991 R-HSA-70613 Reactome R-HSA-70263
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: L-Asp
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002333 R-HSA-70594 R-HSA-70613 controller Reactome R-HSA-70613
evidence: ev w id R-HSA-70613 RO 0002333 R-HSA-70594 R-HSA-70613 controller Reactome R-HSA-70263
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: GOT2 dimer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 RO 0002411 R-HSA-508561 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002411
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70613 RO 0002411 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002411
annotated source: GOT2 transaminates oxaloacetate and glutamate
annotated target: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 BFO 0000066 reaction R-HSA-70938 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: reaction R-HSA-70938 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 15378 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 15378 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 16474 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 16474 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: TPNH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 16810 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 16810 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: 2OG
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 32551 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002233 CHEBI 32551 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: L-Lys
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 15377 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 15377 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: H2O
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 16927 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 16927 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: SACN
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 18009 R-HSA-70938 Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002234 CHEBI 18009 R-HSA-70938 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: TPN
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 RO 0002411 R-HSA-71037 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002411
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002333 R-HSA-70925 R-HSA-70938 controller Reactome R-HSA-70938
evidence: ev w id R-HSA-70938 RO 0002333 R-HSA-70925 R-HSA-70938 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: AASS tetramer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70938 RO 0002413 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
annotated target: AASS tetramer oxidises SACN to 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O' 'null' 'AASS tetramer oxidises SACN to 2AMAS' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 BFO 0000066 reaction R-HSA-70940 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: reaction R-HSA-70940 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 15377 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 15377 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: H2O
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 16927 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 16927 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: SACN
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 57540 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002233 CHEBI 57540 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: NAD
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 15378 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 15378 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 29985 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 29985 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: Glu
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 57945 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 57945 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: NADH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 RO 0004009 transported CHEBI 15753 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0004009
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: aKADA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 58321 R-HSA-70940 Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002234 CHEBI 58321 R-HSA-70940 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002333 R-HSA-70925 R-HSA-70940 controller Reactome R-HSA-70940
evidence: ev w id R-HSA-70940 RO 0002333 R-HSA-70925 R-HSA-70940 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: AASS tetramer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70940 RO 0002413 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: AASS tetramer oxidises SACN to 2AMAS
annotated target: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'AASS tetramer oxidises SACN to 2AMAS' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 BFO 0000066 reaction R-HSA-70941 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: reaction R-HSA-70941 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 15377 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 15377 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: H2O
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 57540 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 57540 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: NAD
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 58321 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002233 CHEBI 58321 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: 2AMAS
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 15378 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 15378 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: H+
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 57945 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 57945 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: NADH
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-372480 RO 0004009 transported CHEBI 16810 R-HSA-372480 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0004009
annotated source: Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
annotated target: 2OG
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 58672 R-HSA-70941 Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002234 CHEBI 58672 R-HSA-70941 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: 2AMA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002333 R-HSA-508564 R-HSA-70941 controller Reactome R-HSA-70941
evidence: ev w id R-HSA-70941 RO 0002333 R-HSA-508564 R-HSA-70941 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: ALDH7A1 tetramer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70941 RO 0002413 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002413
annotated source: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
annotated target: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
comment: Provides Input For Rule. The relation 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' 'null' 'alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate' was inferred because: reaction1 has an output that is an input of reaction 2.
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: R-HSA-71064 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000050
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: Lysine catabolism
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 BFO 0000066 reaction R-HSA-70952 location lociGO 0005759 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: BFO_0000066
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: reaction R-HSA-70952 location lociGO 0005759
comment: Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 RO 0002233 CHEBI 16810 R-HSA-70952 Reactome R-HSA-70952
evidence: ev w id R-HSA-70952 RO 0002233 CHEBI 16810 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: 2OG
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 RO 0002233 CHEBI 58672 R-HSA-70952 Reactome R-HSA-70952
evidence: ev w id R-HSA-70952 RO 0002233 CHEBI 58672 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002233
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: 2AMA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 RO 0002234 CHEBI 15753 R-HSA-70952 Reactome R-HSA-70952
evidence: ev w id R-HSA-70952 RO 0002234 CHEBI 15753 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: aKADA
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 RO 0002234 CHEBI 29985 R-HSA-70952 Reactome R-HSA-70952
evidence: ev w id R-HSA-70952 RO 0002234 CHEBI 29985 R-HSA-70952 Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002234
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: Glu
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21

Axiom
evidence: ev w id R-HSA-70952 RO 0002333 R-HSA-508545 R-HSA-70952 controller Reactome R-HSA-70952
evidence: ev w id R-HSA-70952 RO 0002333 R-HSA-508545 R-HSA-70952 controller Reactome R-HSA-71064
provided by: https://reactome.org
annotated property: RO_0002333
annotated source: alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
annotated target: AADAT dimer
comment: Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
contributor: GOC:reactome_curators
date: 2023-06-21