reaction from external pathway R-HSA-70263
GOT2 transaminates oxaloacetate and glutamate
glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
Transporter Rule. This reaction represents the activity of transporting
Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
For logical inference, import the integrated tbox ontology http://purl.obolibrary.org/obo/go/extensions/go-lego-reacto.owl
Automated change 2026-01-08: GO:0006554 replaced by GO:0019477
Imported from Reactome: https://reactome.org/content/detail/R-HSA-71064
Lysine catabolism - imported from: Reactome
In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).
Occurs In Rule. This relation was asserted based on the location of the enabling molecule.
Provides Input For Rule. The relation 'alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+' 'null' 'glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2' was inferred because: reaction1 has an output that is an input of reaction 2.
Provides Input For Rule. The relation 'CRYM reduces P2C to PPCA' 'null' 'PIPOX oxidises PPCA to P6C' was inferred because: reaction1 has an output that is an input of reaction 2.
Provides Input For Rule. The relation 'PXLP-K278-PHYKPL tetramer hydrolyses 5PHL' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
This relation was inferred because something that was an input to the reaction started out in the target location null and then, as a consequence of the reaction/process was transported to null
Provides Input For Rule. The relation 'PIPOX oxidises PPCA to P6C' 'null' 'P6C transforms to 2AMAS' was inferred because: reaction1 has an output that is an input of reaction 2.
Provides Input For Rule. The relation 'P6C transforms to 2AMAS' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
This relation was inferred because something that was an input to the reaction started in null and then, as a consequence of the reaction/process was transported to the target end location null
Provides Input For Rule. The relation 'lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O' 'null' 'AASS tetramer oxidises SACN to 2AMAS' was inferred because: reaction1 has an output that is an input of reaction 2.
Provides Input For Rule. The relation 'AASS tetramer oxidises SACN to 2AMAS' 'null' 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' was inferred because: reaction1 has an output that is an input of reaction 2.
Provides Input For Rule. The relation 'alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+' 'null' 'alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate' was inferred because: reaction1 has an output that is an input of reaction 2.