format-version: 1.2
data-version: releases/2024-03-06
date: 21:07:2015 00:00
saved-by: anne.morgat@isb-sib.ch
synonymtypedef: FORMULA "FORMULA"
synonymtypedef: InChI "InChI"
default-namespace: unipathway_ontology
remark: UniPathway Release 2015_03
ontology: upa

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
disjoint_from: BFO:0000003 ! occurrent

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []

[Term]
id: BFO:0000004
name: independent continuant
def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
is_a: BFO:0000002 ! continuant

[Term]
id: BFO:0000015
name: process
def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
is_a: BFO:0000003 ! occurrent

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant

[Term]
id: GO:0003674
name: molecular_function
is_a: BFO:0000015 ! process
property_value: IAO:0000589 "molecular process" xsd:string

[Term]
id: GO:0003824
name: catalytic activity
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0008150
name: biological_process
is_a: BFO:0000015 ! process

[Term]
id: GO:0016301
name: kinase activity
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016740
name: transferase activity
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
is_a: GO:0016740 ! transferase activity

[Term]
id: UPa:UCR00000
name: reaction
namespace: reaction
def: "A chemical reaction involved in a UniPathway pathway." []
xref: GO:0003824

[Term]
id: UPa:UCR00005
name: H(2)O + urea-1-carboxylate = 2 CO(2) + 2 NH(3)
namespace: reaction
xref: KEGG:R00005 "KEGG reaction"
xref: METACYC:ALLOPHANATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19032 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate
relationship: has_input_compound UPa:UPC01010 ! urea-1-carboxylate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: part_of UPa:UER00372 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 2/2
relationship: part_of UPa:UER00372 ! CO(2) and NH(3) from urea (allophanate route): step 2/2

[Term]
id: UPa:UCR00010
name: H(2)O + alpha,alpha-trehalose = 2 D-glucose
namespace: reaction
xref: KEGG:R00010 "KEGG reaction"
xref: METACYC:TREHALA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20871 "Rhea reaction"
xref: RHEA:32678 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01083 {cardinality="1"} ! alpha,alpha-trehalose
relationship: has_input_compound UPa:UPC01083 ! alpha,alpha-trehalose
relationship: has_output_compound UPa:UPC00031 {cardinality="1"} ! D-glucose
relationship: has_output_compound UPa:UPC00031 ! D-glucose
relationship: part_of UPa:UER00535 {cardinality="1", direction="LR", order="1"} ! D-glucose from alpha,alpha-trehalose: step 1/1
relationship: part_of UPa:UER00535 ! D-glucose from alpha,alpha-trehalose: step 1/1

[Term]
id: UPa:UCR00013
name: 2 glyoxylate = 2-hydroxy-3-oxopropanoate + CO(2)
namespace: reaction
xref: KEGG:R00013 "KEGG reaction"
xref: METACYC:GLYOCARBOLIG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10139 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00048 ! glyoxylate
relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate
relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate
relationship: part_of UPa:UER00831 ! 3-phospho-D-glycerate from glycolate: step 2/4
relationship: part_of UPa:UER00831 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 2/4

[Term]
id: UPa:UCR00014
name: pyruvate + thiamine diphosphate = 2-hydroxyethyl-ThPP + CO(2)
namespace: reaction
xref: KEGG:R00014 "KEGG reaction"
xref: METACYC:RXN-12583 "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate
relationship: has_input_compound UPa:UPC00068 ! thiamine diphosphate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP
relationship: has_output_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP
relationship: part_of UPa:UER00059 ! L-valine from pyruvate: step 1/4
relationship: part_of UPa:UER00059 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 1/4

[Term]
id: UPa:UCR00021
name: 2 L-glutamate + 2 oxidized ferredoxin = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced ferredoxin
namespace: reaction
xref: KEGG:R00021 "KEGG reaction"
xref: METACYC:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12131 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00139 ! oxidized ferredoxin
relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00064 ! L-glutamine
relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00138 ! reduced ferredoxin
relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin
relationship: part_of UPa:UER00691 ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1
relationship: part_of UPa:UER00691 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1

[Term]
id: UPa:UCR00036
name: 2 5-aminolevulinate = 2 H(2)O + porphobilinogen
namespace: reaction
xref: KEGG:R00036 "KEGG reaction"
xref: METACYC:PORPHOBILSYNTH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24067 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate
relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen
relationship: has_output_compound UPa:UPC00931 ! porphobilinogen
relationship: part_of UPa:UER00318 ! coproporphyrinogen-III from 5-aminolevulinate: step 1/4
relationship: part_of UPa:UER00318 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 1/4

[Term]
id: UPa:UCR00066
name: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = 5-amino-6-(D-ribitylamino)uracil + riboflavin
namespace: reaction
xref: KEGG:R00066 "KEGG reaction"
xref: METACYC:RIBOFLAVIN-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20775 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine
relationship: has_input_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine
relationship: has_output_compound UPa:UPC00255 {cardinality="1"} ! riboflavin
relationship: has_output_compound UPa:UPC00255 ! riboflavin
relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil
relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil
relationship: part_of UPa:UER00405 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2
relationship: part_of UPa:UER00405 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2

[Term]
id: UPa:UCR00084
name: H(2)O + 4 porphobilinogen = 4 NH(3) + hydroxymethylbilane
namespace: reaction
xref: KEGG:R00084 "KEGG reaction"
xref: METACYC:OHMETHYLBILANESYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13188 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen
relationship: has_input_compound UPa:UPC00931 ! porphobilinogen
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane
relationship: has_output_compound UPa:UPC01024 ! hydroxymethylbilane
relationship: part_of UPa:UER00319 ! coproporphyrinogen-III from 5-aminolevulinate: step 2/4
relationship: part_of UPa:UER00319 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 2/4

[Term]
id: UPa:UCR00093
name: 2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH
namespace: reaction
xref: KEGG:R00093 "KEGG reaction"
xref: METACYC:GLUTAMATE-SYNTHASE-NADH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13756 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00064 ! L-glutamine
relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00690 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1
relationship: part_of UPa:UER00690 ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1

[Term]
id: UPa:UCR00114
name: 2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH
namespace: reaction
xref: KEGG:R00114 "KEGG reaction"
xref: METACYC:GLUTAMATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15504 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00064 ! L-glutamine
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00689 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1
relationship: part_of UPa:UER00689 ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1

[Term]
id: UPa:UCR00127
name: AMP + ATP = 2 ADP
namespace: reaction
xref: KEGG:R00127 "KEGG reaction"
xref: METACYC:ADENYL-KIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12976 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00020 ! AMP
relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: part_of UPa:UER00649 {cardinality="1", direction="RL", order="1"} ! AMP from ADP: step 1/1
relationship: part_of UPa:UER00649 ! AMP from ADP: step 1/1

[Term]
id: UPa:UCR00130
name: 3'-dephospho-CoA + ATP = ADP + CoA
namespace: reaction
xref: KEGG:R00130 "KEGG reaction"
xref: METACYC:DEPHOSPHOCOAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18248 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA
relationship: has_input_compound UPa:UPC00882 ! 3'-dephospho-CoA
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: part_of UPa:UER00356 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 5/5
relationship: part_of UPa:UER00356 ! CoA from (R)-pantothenate: step 5/5

[Term]
id: UPa:UCR00131
name: H(2)O + urea = CO(2) + 2 NH(3)
namespace: reaction
xref: KEGG:R00131 "KEGG reaction"
xref: METACYC:UREASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20560 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_input_compound UPa:UPC00086 ! urea
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: part_of UPa:UER00370 ! CO(2) and NH(3) from urea (urease route): step 1/1
relationship: part_of UPa:UER00370 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (urease route): step 1/1

[Term]
id: UPa:UCR00137
name: ATP + nicotinamide D-ribonucleotide = NAD(+) + diphosphate
namespace: reaction
xref: KEGG:R00137 "KEGG reaction"
xref: METACYC:2.7.7.1-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21363 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide
relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: part_of UPa:UER00600 {cardinality="1", direction="LR", order="1"} ! NAD(+) from nicotinamide D-ribonucleotide: step 1/1
relationship: part_of UPa:UER00600 ! NAD(+) from nicotinamide D-ribonucleotide: step 1/1

[Term]
id: UPa:UCR00150
name: ATP + CO(2) + NH(3) = ADP + carbamoyl phosphate
namespace: reaction
xref: KEGG:R00150 "KEGG reaction"
xref: METACYC:CARBAMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10155 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate
relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate
relationship: part_of UPa:UER00366 ! CO(2) and NH(3) from carbamoyl phosphate: step 1/1
relationship: part_of UPa:UER00366 {cardinality="1", direction="RL", order="1"} ! CO(2) and NH(3) from carbamoyl phosphate: step 1/1

[Term]
id: UPa:UCR00156
name: ATP + UDP = ADP + UTP
namespace: reaction
xref: KEGG:R00156 "KEGG reaction"
xref: METACYC:UDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25101 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00015 ! UDP
relationship: has_input_compound UPa:UPC00015 {cardinality="1"} ! UDP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00075 {cardinality="1"} ! UTP
relationship: has_output_compound UPa:UPC00075 ! UTP
relationship: part_of UPa:UER00276 ! CTP from UDP: step 1/2
relationship: part_of UPa:UER00276 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 1/2

[Term]
id: UPa:UCR00158
name: ATP + UMP = ADP + UDP
namespace: reaction
xref: KEGG:R00158 "KEGG reaction"
xref: METACYC:RXN-12002 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24403 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP
relationship: has_input_compound UPa:UPC00105 ! UMP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP
relationship: has_output_compound UPa:UPC00015 ! UDP
relationship: part_of UPa:UER00274 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMK/CMK route): step 1/1
relationship: part_of UPa:UER00274 ! UDP from UMP (UMK/CMK route): step 1/1
relationship: part_of UPa:UER00275 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMPK route): step 1/1
relationship: part_of UPa:UER00275 ! UDP from UMP (UMPK route): step 1/1

[Term]
id: UPa:UCR00161
name: ATP + FMN = FAD + diphosphate
namespace: reaction
xref: KEGG:R00161 "KEGG reaction"
xref: METACYC:FADSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17240 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00061 {cardinality="1"} ! FMN
relationship: has_input_compound UPa:UPC00061 ! FMN
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00016 {cardinality="1"} ! FAD
relationship: has_output_compound UPa:UPC00016 ! FAD
relationship: part_of UPa:UER00407 {cardinality="1", direction="LR", order="1"} ! FAD from FMN: step 1/1
relationship: part_of UPa:UER00407 ! FAD from FMN: step 1/1

[Term]
id: UPa:UCR00173
name: H(2)O + pyridoxal 5'-phosphate = phosphate + pyridoxal
namespace: reaction
xref: KEGG:R00173 "KEGG reaction"
xref: METACYC:3.1.3.74-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20536 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00018 ! pyridoxal 5'-phosphate
relationship: has_input_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00250 ! pyridoxal
relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: part_of UPa:UER00301 ! pyridoxal from pyridoxal 5'-phosphate: step 1/1
relationship: part_of UPa:UER00301 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxal 5'-phosphate: step 1/1

[Term]
id: UPa:UCR00174
name: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate
namespace: reaction
xref: KEGG:R00174 "KEGG reaction"
xref: METACYC:PYRIDOXKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10227 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00250 ! pyridoxal
relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate
relationship: part_of UPa:UER00298 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxal: step 1/1
relationship: part_of UPa:UER00298 ! pyridoxal 5'-phosphate from pyridoxal: step 1/1

[Term]
id: UPa:UCR00177
name: S-adenosyl-L-methionine + diphosphate + phosphate = ATP + H(2)O + L-methionine
namespace: reaction
xref: KEGG:R00177 "KEGG reaction"
xref: METACYC:S-ADENMETSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21083 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00002 ! ATP
relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: part_of UPa:UER00080 ! S-adenosyl-L-methionine from L-methionine: step 1/1
relationship: part_of UPa:UER00080 {cardinality="1", direction="RL", order="1"} ! S-adenosyl-L-methionine from L-methionine: step 1/1

[Term]
id: UPa:UCR00178
name: H(+) + S-adenosyl-L-methionine = CO(2) + S-adenosylmethioninamine
namespace: reaction
xref: KEGG:R00178 "KEGG reaction"
xref: METACYC:SAMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15984 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC01137 ! S-adenosylmethioninamine
relationship: has_output_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine
relationship: part_of UPa:UER00451 {cardinality="1", direction="LR", order="1"} ! S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1
relationship: part_of UPa:UER00451 ! S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1

[Term]
id: UPa:UCR00179
name: S-adenosyl-L-methionine = 1-aminocyclopropanecarboxylate + S-methyl-5'-thioadenosine
namespace: reaction
xref: KEGG:R00179 "KEGG reaction"
xref: METACYC:4.4.1.14-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21747 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate
relationship: has_output_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate
relationship: part_of UPa:UER00562 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 1/2
relationship: part_of UPa:UER00562 ! ethylene from S-adenosyl-L-methionine: step 1/2

[Term]
id: UPa:UCR00181
name: AMP + H(2)O = IMP + NH(3)
namespace: reaction
xref: KEGG:R00181 "KEGG reaction"
xref: METACYC:AMP-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14780 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_input_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00130 ! IMP
relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: part_of UPa:UER00663 ! IMP from AMP: step 1/1
relationship: part_of UPa:UER00663 {cardinality="1", direction="LR", order="1"} ! IMP from AMP: step 1/1

[Term]
id: UPa:UCR00185
name: ATP + adenosine = ADP + AMP
namespace: reaction
xref: KEGG:R00185 "KEGG reaction"
xref: METACYC:ADENOSINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20827 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00212 {cardinality="1"} ! adenosine
relationship: has_input_compound UPa:UPC00212 ! adenosine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: part_of UPa:UER00659 ! AMP from adenosine: step 1/1
relationship: part_of UPa:UER00659 {cardinality="1", direction="LR", order="1"} ! AMP from adenosine: step 1/1

[Term]
id: UPa:UCR00189
name: ATP + NH(3) + deamido-NAD(+) = AMP + NAD(+) + diphosphate
namespace: reaction
xref: KEGG:R00189 "KEGG reaction"
xref: METACYC:NAD-SYNTH-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21191 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+)
relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: part_of UPa:UER00333 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (ammonia route): step 1/1
relationship: part_of UPa:UER00333 ! NAD(+) from deamido-NAD(+) (ammonia route): step 1/1

[Term]
id: UPa:UCR00190
name: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine
namespace: reaction
xref: KEGG:R00190 "KEGG reaction"
xref: METACYC:ADENPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16612 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_input_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine
relationship: has_output_compound UPa:UPC00147 ! adenine
relationship: part_of UPa:UER00646 {cardinality="1", direction="RL", order="1"} ! AMP from adenine: step 1/1
relationship: part_of UPa:UER00646 ! AMP from adenine: step 1/1

[Term]
id: UPa:UCR00191
name: 3',5'-cyclic AMP + H(2)O = AMP
namespace: reaction
xref: KEGG:R00191 "KEGG reaction"
xref: METACYC:RXN0-5038 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25280 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00575 ! 3',5'-cyclic AMP
relationship: has_input_compound UPa:UPC00575 {cardinality="1"} ! 3',5'-cyclic AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: part_of UPa:UER00747 ! AMP from 3',5'-cyclic AMP: step 1/1
relationship: part_of UPa:UER00747 {cardinality="1", direction="LR", order="1"} ! AMP from 3',5'-cyclic AMP: step 1/1

[Term]
id: UPa:UCR00192
name: H(2)O + S-adenosyl-L-homocysteine = L-homocysteine + adenosine
namespace: reaction
xref: KEGG:R00192 "KEGG reaction"
xref: METACYC:ADENOSYLHOMOCYSTEINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21711 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: has_output_compound UPa:UPC00155 ! L-homocysteine
relationship: has_output_compound UPa:UPC00212 ! adenosine
relationship: has_output_compound UPa:UPC00212 {cardinality="1"} ! adenosine
relationship: part_of UPa:UER00076 ! L-homocysteine from S-adenosyl-L-homocysteine: step 1/1
relationship: part_of UPa:UER00076 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from S-adenosyl-L-homocysteine: step 1/1

[Term]
id: UPa:UCR00200
name: ATP + pyruvate = ADP + phosphoenolpyruvate
namespace: reaction
xref: KEGG:R00200 "KEGG reaction"
xref: METACYC:PEPDEPHOS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18160 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: part_of UPa:UER00188 ! pyruvate from D-glyceraldehyde 3-phosphate: step 5/5
relationship: part_of UPa:UER00188 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 5/5

[Term]
id: UPa:UCR00212
name: acetyl-CoA + formate = CoA + pyruvate
namespace: reaction
xref: KEGG:R00212 "KEGG reaction"
xref: METACYC:PYRUVFORMLY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11847 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_input_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: part_of UPa:UER00891 {cardinality="1", direction="RL", order="1"} ! formate from pyruvate: step 1/1
relationship: part_of UPa:UER00891 ! formate from pyruvate: step 1/1

[Term]
id: UPa:UCR00226
name: (S)-2-acetolactate + CO(2) = 2 pyruvate
namespace: reaction
xref: KEGG:R00226 "KEGG reaction"
xref: METACYC:ACETOLACTSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25252 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate
relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: part_of UPa:UER00677 ! (R,R)-butane-2,3-diol from pyruvate: step 1/3
relationship: part_of UPa:UER00677 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 1/3

[Term]
id: UPa:UCR00228
name: CoA + NAD(+) + acetaldehyde = H(+) + NADH + acetyl-CoA
namespace: reaction
xref: KEGG:R00228 "KEGG reaction"
xref: METACYC:ACETALD-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23291 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00084 ! acetaldehyde
relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00798 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetaldehyde: step 1/1
relationship: part_of UPa:UER00798 ! acetyl-CoA from acetaldehyde: step 1/1

[Term]
id: UPa:UCR00230
name: acetyl-CoA + phosphate = CoA + acetyl phosphate
namespace: reaction
xref: KEGG:R00230 "KEGG reaction"
xref: METACYC:PHOSACETYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19524 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate
relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate
relationship: part_of UPa:UER00459 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA from acetate: step 2/2
relationship: part_of UPa:UER00459 ! acetyl-CoA from acetate: step 2/2

[Term]
id: UPa:UCR00233
name: malonyl-CoA = CO(2) + acetyl-CoA
namespace: reaction
xref: KEGG:R00233 "KEGG reaction"
xref: METACYC:MALONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18784 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA
relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: part_of UPa:UER00710 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from malonyl-CoA: step 1/1
relationship: part_of UPa:UER00710 ! acetyl-CoA from malonyl-CoA: step 1/1

[Term]
id: UPa:UCR00238
name: 2 acetyl-CoA = CoA + acetoacetyl-CoA
namespace: reaction
xref: KEGG:R00238 "KEGG reaction"
xref: METACYC:ACETYL-COA-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21039 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA
relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA
relationship: part_of UPa:UER00101 {cardinality="1", direction="LR", order="1"} ! (R)-mevalonate from acetyl-CoA: step 1/3
relationship: part_of UPa:UER00101 ! (R)-mevalonate from acetyl-CoA: step 1/3

[Term]
id: UPa:UCR00239
name: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
namespace: reaction
xref: KEGG:R00239 "KEGG reaction"
xref: METACYC:GLUTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14880 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC03287 ! L-glutamyl 5-phosphate
relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate
relationship: part_of UPa:UER00359 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 1/2
relationship: part_of UPa:UER00359 ! L-glutamate 5-semialdehyde from L-glutamate: step 1/2

[Term]
id: UPa:UCR00243
name: H(2)O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH(3)
namespace: reaction
xref: KEGG:R00243 "KEGG reaction"
xref: METACYC:GLUTAMATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15136 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00591 ! crotonoyl-CoA from L-glutamate: step 1/5
relationship: part_of UPa:UER00591 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 1/5

[Term]
id: UPa:UCR00253
name: ATP + L-glutamate + NH(3) = ADP + L-glutamine + phosphate
namespace: reaction
xref: KEGG:R00253 "KEGG reaction"
xref: METACYC:GLUTAMINESYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16172 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00064 ! L-glutamine
relationship: part_of UPa:UER01025 {cardinality="1", direction="LR", order="1"} ! L-glutamine from L-glutamate: step 1/1
relationship: part_of UPa:UER01025 ! L-glutamine from L-glutamate: step 1/1

[Term]
id: UPa:UCR00256
name: H(2)O + L-glutamine = L-glutamate + NH(3)
namespace: reaction
xref: KEGG:R00256 "KEGG reaction"
xref: METACYC:GLUTAMIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15892 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: part_of UPa:UER00040 ! L-tryptophan from chorismate: step 1/5
relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 1/5
relationship: part_of UPa:UER00149 ! 4-aminobenzoate from chorismate: step 1/2
relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="2"} ! 4-aminobenzoate from chorismate: step 1/2

[Term]
id: UPa:UCR00257
name: ATP + H(2)O + L-glutamine + deamido-NAD(+) = AMP + L-glutamate + NAD(+) + diphosphate
namespace: reaction
xref: KEGG:R00257 "KEGG reaction"
xref: METACYC:NAD-SYNTH-GLN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24387 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+)
relationship: has_input_compound UPa:UPC00857 ! deamido-NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: part_of UPa:UER00334 ! NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1
relationship: part_of UPa:UER00334 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1

[Term]
id: UPa:UCR00258
name: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate
namespace: reaction
xref: KEGG:R00258 "KEGG reaction"
xref: METACYC:ALANINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19456 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00041 ! L-alanine
relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: part_of UPa:UER00586 ! pyruvate from L-alanine: step 1/1
relationship: part_of UPa:UER00586 {cardinality="1", direction="LR", order="1"} ! pyruvate from L-alanine: step 1/1

[Term]
id: UPa:UCR00259
name: L-glutamate + acetyl-CoA = CoA + N-acetyl-L-glutamate
namespace: reaction
xref: KEGG:R00259 "KEGG reaction"
xref: METACYC:N-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24295 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate
relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate
relationship: part_of UPa:UER00106 ! N(2)-acetyl-L-ornithine from L-glutamate: step 1/4
relationship: part_of UPa:UER00106 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 1/4

[Term]
id: UPa:UCR00262
name: (2S,3S)-3-methyl-L-aspartate = L-glutamate
namespace: reaction
xref: KEGG:R00262 "KEGG reaction"
xref: METACYC:METHYLASPARTATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12860 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate
relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: part_of UPa:UER00617 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 1/4
relationship: part_of UPa:UER00617 ! acetate and pyruvate from L-glutamate: step 1/4

[Term]
id: UPa:UCR00264
name: 2,5-dioxopentanoate + H(2)O + NADP(+) = 2-oxoglutarate + H(+) + NADPH
namespace: reaction
xref: KEGG:R00264 "KEGG reaction"
xref: METACYC:25-DIOXOVALERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11299 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate
relationship: has_input_compound UPa:UPC00433 ! 2,5-dioxopentanoate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00573 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2
relationship: part_of UPa:UER00573 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2

[Term]
id: UPa:UCR00267
name: NADP(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADPH
namespace: reaction
xref: KEGG:R00267 "KEGG reaction"
xref: METACYC:ISOCITDEH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: METACYC:RXN-8642 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:19632 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00311 ! isocitrate
relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00995 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1
relationship: part_of UPa:UER00995 ! 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1

[Term]
id: UPa:UCR00271
name: 2-oxoglutarate + H(2)O + acetyl-CoA = (R)-homocitrate + CoA
namespace: reaction
xref: KEGG:R00271 "KEGG reaction"
xref: METACYC:HOMOCITRATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12932 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate
relationship: has_output_compound UPa:UPC01251 ! (R)-homocitrate
relationship: part_of UPa:UER00028 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 1/5
relationship: part_of UPa:UER00028 ! L-alpha-aminoadipate from 2-oxoglutarate: step 1/5

[Term]
id: UPa:UCR00272
name: 2-oxoglutarate = CO(2) + succinate semialdehyde
namespace: reaction
xref: KEGG:R00272 "KEGG reaction"
xref: METACYC:RXN-7774 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10527 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde
relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde
relationship: part_of UPa:UER01001 ! succinate from 2-oxoglutarate (transferase route): step 1/2
relationship: part_of UPa:UER01001 {cardinality="1", direction="LR", order="1"} ! succinate from 2-oxoglutarate (transferase route): step 1/2

[Term]
id: UPa:UCR00277
name: H(2)O + O(2) + pyridoxamine 5'-phosphate = H(2)O(2) + NH(3) + pyridoxal 5'-phosphate
namespace: reaction
xref: KEGG:R00277 "KEGG reaction"
xref: METACYC:PMPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15820 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate
relationship: has_input_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: part_of UPa:UER00304 ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1
relationship: part_of UPa:UER00304 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1

[Term]
id: UPa:UCR00278
name: O(2) + pyridoxine 5'-phosphate = H(2)O(2) + pyridoxal 5'-phosphate
namespace: reaction
xref: KEGG:R00278 "KEGG reaction"
xref: METACYC:PNPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15152 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate
relationship: has_input_compound UPa:UPC00627 ! pyridoxine 5'-phosphate
relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00018 ! pyridoxal 5'-phosphate
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: part_of UPa:UER00305 ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1
relationship: part_of UPa:UER00305 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1

[Term]
id: UPa:UCR00286
name: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 2 H(+) + 2 NADH + UDP-alpha-D-glucuronate
namespace: reaction
xref: KEGG:R00286 "KEGG reaction"
xref: METACYC:UGD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23599 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose
relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate
relationship: has_output_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate
relationship: part_of UPa:UER00491 ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1
relationship: part_of UPa:UER00491 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1

[Term]
id: UPa:UCR00294
name: 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide = H(2)O + 2 ferricytochrome c + nitrous oxide
namespace: reaction
xref: KEGG:R00294 "KEGG reaction"
xref: METACYC:NITRIC-OXIDE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10991 "Rhea reaction"
xref: RHEA:30214 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c
relationship: has_input_compound UPa:UPC00126 ! ferrocytochrome c
relationship: has_input_compound UPa:UPC00533 ! nitric oxide
relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c
relationship: has_output_compound UPa:UPC00125 ! ferricytochrome c
relationship: has_output_compound UPa:UPC00887 ! nitrous oxide
relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide
relationship: part_of UPa:UER00708 {cardinality="1", direction="LR", order="1"} ! dinitrogen from nitrate: step 3/4
relationship: part_of UPa:UER00708 ! dinitrogen from nitrate: step 3/4

[Term]
id: UPa:UCR00299
name: ATP + D-glucose = ADP + D-glucose 6-phosphate
namespace: reaction
xref: KEGG:R00299 "KEGG reaction"
xref: METACYC:GLUCOKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17828 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00031 ! D-glucose
relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate
relationship: has_output_compound UPa:UPC00092 ! D-glucose 6-phosphate
relationship: part_of UPa:UER00180 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4
relationship: part_of UPa:UER00180 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4

[Term]
id: UPa:UCR00310
name: Fe2+ + protoporphyrin-IX = 2 H(+) + protoheme
namespace: reaction
xref: KEGG:R00310 "KEGG reaction"
xref: METACYC:PROTOHEMEFERROCHELAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22587 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02191 ! protoporphyrin-IX
relationship: has_input_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX
relationship: has_input_compound UPa:UPC14818 {cardinality="1"} ! Fe2+
relationship: has_input_compound UPa:UPC14818 ! Fe2+
relationship: has_output_compound UPa:UPC00032 {cardinality="1"} ! protoheme
relationship: has_output_compound UPa:UPC00032 ! protoheme
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00325 {cardinality="1", direction="LR", order="1"} ! protoheme from protoporphyrin-IX: step 1/1
relationship: part_of UPa:UER00325 ! protoheme from protoporphyrin-IX: step 1/1

[Term]
id: UPa:UCR00315
name: ATP + acetate = ADP + acetyl phosphate
namespace: reaction
xref: KEGG:R00315 "KEGG reaction"
xref: METACYC:ACETATEKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11355 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_input_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate
relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate
relationship: part_of UPa:UER00458 ! acetyl-CoA from acetate: step 1/2
relationship: part_of UPa:UER00458 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetate: step 1/2

[Term]
id: UPa:UCR00325
name: L-citramalate = acetate + pyruvate
namespace: reaction
xref: KEGG:R00325 "KEGG reaction"
xref: METACYC:CITRAMALATE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15548 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate
relationship: has_input_compound UPa:UPC02614 ! L-citramalate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: part_of UPa:UER00620 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 4/4
relationship: part_of UPa:UER00620 ! acetate and pyruvate from L-glutamate: step 4/4

[Term]
id: UPa:UCR00336
name: H(2)O + ppGpp = GDP + diphosphate
namespace: reaction
xref: KEGG:R00336 "KEGG reaction"
xref: METACYC:PPGPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14256 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC01228 {cardinality="1"} ! ppGpp
relationship: has_input_compound UPa:UPC01228 ! ppGpp
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP
relationship: has_output_compound UPa:UPC00035 ! GDP
relationship: part_of UPa:UER00886 ! ppGpp from GDP: step 1/1
relationship: part_of UPa:UER00886 {cardinality="1", direction="RL", order="1"} ! ppGpp from GDP: step 1/1

[Term]
id: UPa:UCR00342
name: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
namespace: reaction
xref: KEGG:R00342 "KEGG reaction"
xref: METACYC:MALATE-DEH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21435 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00149 ! (S)-malate
relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00036 ! oxaloacetate
relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00721 ! oxaloacetate from (S)-malate: step 1/1
relationship: part_of UPa:UER00721 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate: step 1/1

[Term]
id: UPa:UCR00351
name: CoA + citrate = H(2)O + acetyl-CoA + oxaloacetate
namespace: reaction
xref: KEGG:R00351 "KEGG reaction"
xref: METACYC:CITSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16848 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate
relationship: has_input_compound UPa:UPC00158 ! citrate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate
relationship: has_output_compound UPa:UPC00036 ! oxaloacetate
relationship: part_of UPa:UER00717 ! isocitrate from oxaloacetate: step 1/2
relationship: part_of UPa:UER00717 {cardinality="1", direction="RL", order="1"} ! isocitrate from oxaloacetate: step 1/2

[Term]
id: UPa:UCR00355
name: 2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate
namespace: reaction
xref: KEGG:R00355 "KEGG reaction"
xref: METACYC:ASPAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21827 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate
relationship: has_output_compound UPa:UPC00036 ! oxaloacetate
relationship: part_of UPa:UER01024 ! L-aspartate from oxaloacetate: step 1/1
relationship: part_of UPa:UER01024 {cardinality="1", direction="RL", order="1"} ! L-aspartate from oxaloacetate: step 1/1

[Term]
id: UPa:UCR00361
name: (S)-malate + Quinone = Hydroquinone + oxaloacetate
namespace: reaction
xref: KEGG:R00361 "KEGG reaction"
xref: METACYC:MALATE-DEHYDROGENASE-ACCEPTOR-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22559 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00149 ! (S)-malate
relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate
relationship: has_input_compound UPa:UPC15602 ! Quinone
relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone
relationship: has_output_compound UPa:UPC00036 ! oxaloacetate
relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate
relationship: has_output_compound UPa:UPC15603 ! Hydroquinone
relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone
relationship: part_of UPa:UER01008 ! oxaloacetate from (S)-malate (quinone route): step 1/1
relationship: part_of UPa:UER01008 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate (quinone route): step 1/1

[Term]
id: UPa:UCR00367
name: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine
namespace: reaction
xref: KEGG:R00367 "KEGG reaction"
xref: METACYC:GLYCINE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19940 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00213 ! sarcosine
relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine
relationship: part_of UPa:UER00381 ! betaine from glycine: step 1/3
relationship: part_of UPa:UER00381 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 1/3

[Term]
id: UPa:UCR00369
name: L-alanine + glyoxylate = glycine + pyruvate
namespace: reaction
xref: KEGG:R00369 "KEGG reaction"
xref: METACYC:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24251 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_input_compound UPa:UPC00041 ! L-alanine
relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_input_compound UPa:UPC00048 ! glyoxylate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00037 ! glycine
relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: part_of UPa:UER00428 {cardinality="1", direction="LR", order="1"} ! glycine from glyoxylate: step 1/1
relationship: part_of UPa:UER00428 ! glycine from glyoxylate: step 1/1

[Term]
id: UPa:UCR00371
name: acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoic acid
namespace: reaction
xref: KEGG:R00371 "KEGG reaction"
xref: METACYC:AKBLIG-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:20739 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid
relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid
relationship: part_of UPa:UER00506 ! glycine from L-threonine: step 2/2
relationship: part_of UPa:UER00506 {cardinality="1", direction="RL", order="1"} ! glycine from L-threonine: step 2/2

[Term]
id: UPa:UCR00372
name: 2-oxoglutarate + glycine = L-glutamate + glyoxylate
namespace: reaction
xref: KEGG:R00372 "KEGG reaction"
xref: METACYC:GLYCINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14092 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: part_of UPa:UER00913 ! glycine from 2-phosphoglycolate: step 3/3
relationship: part_of UPa:UER00913 {cardinality="1", direction="RL", order="1"} ! glycine from 2-phosphoglycolate: step 3/3

[Term]
id: UPa:UCR00396
name: H(2)O + L-alanine + NAD(+) = H(+) + NADH + NH(3) + pyruvate
namespace: reaction
xref: KEGG:R00396 "KEGG reaction"
xref: METACYC:ALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18408 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00041 ! L-alanine
relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00585 ! NH(3) and pyruvate from L-alanine: step 1/1
relationship: part_of UPa:UER00585 {cardinality="1", direction="LR", order="1"} ! NH(3) and pyruvate from L-alanine: step 1/1

[Term]
id: UPa:UCR00401
name: L-alanine = D-alanine
namespace: reaction
xref: KEGG:R00401 "KEGG reaction"
xref: METACYC:ALARACECAT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20252 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00041 ! L-alanine
relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00133 ! D-alanine
relationship: has_output_compound UPa:UPC00133 {cardinality="1"} ! D-alanine
relationship: part_of UPa:UER00497 ! D-alanine from L-alanine: step 1/1
relationship: part_of UPa:UER00497 {cardinality="1", direction="LR", order="1"} ! D-alanine from L-alanine: step 1/1

[Term]
id: UPa:UCR00405
name: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
namespace: reaction
xref: KEGG:R00405 "KEGG reaction"
xref: METACYC:SUCCCOASYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17664 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00042 ! succinate
relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA
relationship: part_of UPa:UER00999 {cardinality="1", direction="RL", order="1"} ! succinate from succinyl-CoA (ligase route): step 1/1
relationship: part_of UPa:UER00999 ! succinate from succinyl-CoA (ligase route): step 1/1

[Term]
id: UPa:UCR00410
name: acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate
namespace: reaction
xref: KEGG:R00410 "KEGG reaction"
xref: METACYC:RXNI-2 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25483 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00164 ! acetoacetate
relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA
relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA
relationship: part_of UPa:UER00894 ! acetoacetyl-CoA from succinyl-CoA: step 1/1
relationship: part_of UPa:UER00894 {cardinality="1", direction="LR", order="1"} ! acetoacetyl-CoA from succinyl-CoA: step 1/1
relationship: part_of UPa:UER01000 {cardinality="1", direction="LR", order="1"} ! succinate from succinyl-CoA (transferase route): step 1/1
relationship: part_of UPa:UER01000 ! succinate from succinyl-CoA (transferase route): step 1/1

[Term]
id: UPa:UCR00411
name: H(2)O + N(2)-succinyl-L-glutamic acid = L-glutamate + succinate
namespace: reaction
xref: KEGG:R00411 "KEGG reaction"
xref: METACYC:SUCCGLUDESUCC-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15172 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid
relationship: has_input_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: part_of UPa:UER00283 ! L-glutamate and succinate from L-arginine: step 5/5
relationship: part_of UPa:UER00283 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 5/5

[Term]
id: UPa:UCR00412
name: acceptor + succinate = fumarate + reduced acceptor
namespace: reaction
xref: KEGG:R00412 "KEGG reaction"
xref: RHEA:16360 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_input_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: part_of UPa:UER01005 ! fumarate from succinate (bacterial route): step 1/1
relationship: part_of UPa:UER01005 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (bacterial route): step 1/1

[Term]
id: UPa:UCR00416
name: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = UDP-N-acetyl-alpha-D-glucosamine + diphosphate
namespace: reaction
xref: KEGG:R00416 "KEGG reaction"
xref: METACYC:NAG1P-URIDYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13512 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00075 ! UTP
relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP
relationship: has_input_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate
relationship: has_input_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine
relationship: has_output_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine
relationship: part_of UPa:UER00533 ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1
relationship: part_of UPa:UER00533 {cardinality="1", direction="LR", order="1"} ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1

[Term]
id: UPa:UCR00425
name: GTP + 3 H(2)O = 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + diphosphate + formate
namespace: reaction
xref: KEGG:R00425 "KEGG reaction"
xref: METACYC:GTP-CYCLOHYDRO-II-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23707 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
relationship: has_output_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
relationship: part_of UPa:UER00400 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4
relationship: part_of UPa:UER00400 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4

[Term]
id: UPa:UCR00428
name: GTP + H(2)O = formamidopyrimidine nucleoside triphosphate
namespace: reaction
xref: KEGG:R00428 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_output_compound UPa:UPC05922 ! formamidopyrimidine nucleoside triphosphate
relationship: has_output_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate
relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1
relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1

[Term]
id: UPa:UCR00429
name: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate
namespace: reaction
xref: KEGG:R00429 "KEGG reaction"
xref: METACYC:GTPPYPHOSKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22091 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate
relationship: has_output_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate
relationship: part_of UPa:UER00884 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 1/2
relationship: part_of UPa:UER00884 ! ppGpp from GTP: step 1/2

[Term]
id: UPa:UCR00451
name: DL-2,6-diaminopimelate = CO(2) + L-lysine
namespace: reaction
xref: KEGG:R00451 "KEGG reaction"
xref: METACYC:DIAMINOPIMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15104 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine
relationship: has_output_compound UPa:UPC00047 ! L-lysine
relationship: part_of UPa:UER00027 ! L-lysine from DL-2,6-diaminopimelate: step 1/1
relationship: part_of UPa:UER00027 {cardinality="1", direction="LR", order="1"} ! L-lysine from DL-2,6-diaminopimelate: step 1/1

[Term]
id: UPa:UCR00469
name: (S)-ureidoglycolate + H(2)O = CO(2) + 2 NH(3) + glyoxylate
namespace: reaction
xref: KEGG:R00469 "KEGG reaction"
xref: METACYC:UREIDOGLYCOLATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19812 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate
relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: part_of UPa:UER00656 {cardinality="1", direction="LR", order="1"} ! glyoxylate from (S)-ureidoglycolate: step 1/1
relationship: part_of UPa:UER00656 ! glyoxylate from (S)-ureidoglycolate: step 1/1

[Term]
id: UPa:UCR00472
name: (S)-malate + CoA = H(2)O + acetyl-CoA + glyoxylate
namespace: reaction
xref: KEGG:R00472 "KEGG reaction"
xref: METACYC:MALSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18184 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate
relationship: has_input_compound UPa:UPC00149 ! (S)-malate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: part_of UPa:UER00720 ! (S)-malate from isocitrate: step 2/2
relationship: part_of UPa:UER00720 {cardinality="1", direction="RL", order="1"} ! (S)-malate from isocitrate: step 2/2

[Term]
id: UPa:UCR00475
name: O(2) + glycolate = H(2)O(2) + glyoxylate
namespace: reaction
xref: KEGG:R00475 "KEGG reaction"
xref: METACYC:RXN-969 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25314 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate
relationship: has_input_compound UPa:UPC00160 ! glycolate
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: part_of UPa:UER00912 ! glycine from 2-phosphoglycolate: step 2/3
relationship: part_of UPa:UER00912 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 2/3

[Term]
id: UPa:UCR00476
name: acceptor + glycolate = glyoxylate + reduced acceptor
namespace: reaction
xref: KEGG:R00476 "KEGG reaction"
xref: METACYC:GLYCOLATEDEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21267 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate
relationship: has_input_compound UPa:UPC00160 ! glycolate
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: part_of UPa:UER00830 ! 3-phospho-D-glycerate from glycolate: step 1/4
relationship: part_of UPa:UER00830 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 1/4

[Term]
id: UPa:UCR00479
name: isocitrate = glyoxylate + succinate
namespace: reaction
xref: KEGG:R00479 "KEGG reaction"
xref: METACYC:ISOCIT-CLEAV-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13248 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00311 ! isocitrate
relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate
relationship: has_output_compound UPa:UPC00048 ! glyoxylate
relationship: part_of UPa:UER00719 {cardinality="1", direction="LR", order="1"} ! (S)-malate from isocitrate: step 1/2
relationship: part_of UPa:UER00719 ! (S)-malate from isocitrate: step 1/2

[Term]
id: UPa:UCR00480
name: ATP + L-aspartate = 4-phospho-L-aspartate + ADP
namespace: reaction
xref: KEGG:R00480 "KEGG reaction"
xref: METACYC:ASPARTATEKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23779 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate
relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate
relationship: part_of UPa:UER00015 {cardinality="1", direction="LR", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 1/4
relationship: part_of UPa:UER00015 ! (S)-tetrahydrodipicolinate from L-aspartate: step 1/4
relationship: part_of UPa:UER00461 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 1/5
relationship: part_of UPa:UER00461 ! L-threonine from L-aspartate: step 1/5
relationship: part_of UPa:UER00462 {cardinality="1", direction="LR", order="1"} ! L-homoserine from L-aspartate: step 1/3
relationship: part_of UPa:UER00462 ! L-homoserine from L-aspartate: step 1/3

[Term]
id: UPa:UCR00481
name: L-aspartate + O(2) = H(2)O(2) + iminoaspartate
namespace: reaction
xref: KEGG:R00481 "KEGG reaction"
xref: RHEA:25879 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC05840 ! iminoaspartate
relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate
relationship: part_of UPa:UER00326 {cardinality="1", direction="LR", order="1"} ! iminoaspartate from L-aspartate (oxidase route): step 1/1
relationship: part_of UPa:UER00326 ! iminoaspartate from L-aspartate (oxidase route): step 1/1

[Term]
id: UPa:UCR00483
name: ATP + L-aspartate + NH(3) = AMP + L-asparagine + diphosphate
namespace: reaction
xref: KEGG:R00483 "KEGG reaction"
xref: METACYC:ASNSYNA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11375 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine
relationship: has_output_compound UPa:UPC00152 ! L-asparagine
relationship: part_of UPa:UER00194 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (ammonia route): step 1/1
relationship: part_of UPa:UER00194 ! L-asparagine from L-aspartate (ammonia route): step 1/1

[Term]
id: UPa:UCR00489
name: L-aspartate = CO(2) + beta-alanine
namespace: reaction
xref: KEGG:R00489 "KEGG reaction"
xref: METACYC:ASPDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19500 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00099 ! beta-alanine
relationship: has_output_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine
relationship: part_of UPa:UER00002 {cardinality="1", direction="LR", order="1"} ! beta-alanine from L-aspartate: step 1/1
relationship: part_of UPa:UER00002 ! beta-alanine from L-aspartate: step 1/1

[Term]
id: UPa:UCR00497
name: ATP + L-gamma-glutamyl-L-cysteine + glycine = ADP + glutathione + phosphate
namespace: reaction
xref: KEGG:R00497 "KEGG reaction"
xref: METACYC:GLUTATHIONE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13560 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine
relationship: has_input_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione
relationship: has_output_compound UPa:UPC00051 ! glutathione
relationship: part_of UPa:UER00210 ! glutathione from L-cysteine and L-glutamate: step 2/2
relationship: part_of UPa:UER00210 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 2/2

[Term]
id: UPa:UCR00509
name: 5'-adenylyl sulfate + ATP = 3'-phospho-5'-adenylyl sulfate + ADP
namespace: reaction
xref: KEGG:R00509 "KEGG reaction"
xref: METACYC:ADENYLYLSULFKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24155 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00224 ! 5'-adenylyl sulfate
relationship: has_input_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate
relationship: has_output_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate
relationship: part_of UPa:UER00205 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 2/3
relationship: part_of UPa:UER00205 ! sulfite from sulfate: step 2/3

[Term]
id: UPa:UCR00512
name: ATP + CMP = ADP + CDP
namespace: reaction
xref: KEGG:R00512 "KEGG reaction"
xref: METACYC:RXN-11832 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11603 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00055 ! CMP
relationship: has_input_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00112 ! CDP
relationship: has_output_compound UPa:UPC00112 {cardinality="1"} ! CDP
relationship: part_of UPa:UER00641 ! CTP from cytidine: step 2/3
relationship: part_of UPa:UER00641 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 2/3

[Term]
id: UPa:UCR00513
name: ATP + cytidine = ADP + CMP
namespace: reaction
xref: KEGG:R00513 "KEGG reaction"
xref: METACYC:CYTIKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24677 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine
relationship: has_input_compound UPa:UPC00475 ! cytidine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: part_of UPa:UER00640 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 1/3
relationship: part_of UPa:UER00640 ! CTP from cytidine: step 1/3

[Term]
id: UPa:UCR00525
name: H(2)O + N-formyl-L-glutamate = L-glutamate + formate
namespace: reaction
xref: KEGG:R00525 "KEGG reaction"
xref: METACYC:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12479 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate
relationship: has_input_compound UPa:UPC01045 ! N-formyl-L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: part_of UPa:UER00554 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2
relationship: part_of UPa:UER00554 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2

[Term]
id: UPa:UCR00527
name: H(2)O + S-formylglutathione = formate + glutathione
namespace: reaction
xref: KEGG:R00527 "KEGG reaction"
xref: METACYC:S-FORMYLGLUTATHIONE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14964 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione
relationship: has_input_compound UPa:UPC01031 ! S-formylglutathione
relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione
relationship: has_output_compound UPa:UPC00051 ! glutathione
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: part_of UPa:UER00623 ! formate from formaldehyde (glutathione route): step 3/3
relationship: part_of UPa:UER00623 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 3/3

[Term]
id: UPa:UCR00529
name: ATP + sulfate = 5'-adenylyl sulfate + diphosphate
namespace: reaction
xref: KEGG:R00529 "KEGG reaction"
xref: METACYC:SULFATE-ADENYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18136 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00059 {cardinality="1"} ! sulfate
relationship: has_input_compound UPa:UPC00059 ! sulfate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate
relationship: has_output_compound UPa:UPC00224 ! 5'-adenylyl sulfate
relationship: part_of UPa:UER00204 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 1/3
relationship: part_of UPa:UER00204 ! sulfite from sulfate: step 1/3

[Term]
id: UPa:UCR00549
name: ATP + riboflavin = ADP + FMN
namespace: reaction
xref: KEGG:R00549 "KEGG reaction"
xref: METACYC:RIBOFLAVINKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14360 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00255 ! riboflavin
relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN
relationship: has_output_compound UPa:UPC00061 ! FMN
relationship: part_of UPa:UER00406 ! FMN from riboflavin (ATP route): step 1/1
relationship: part_of UPa:UER00406 {cardinality="1", direction="LR", order="1"} ! FMN from riboflavin (ATP route): step 1/1

[Term]
id: UPa:UCR00551
name: H(2)O + L-arginine = L-ornithine + urea
namespace: reaction
xref: KEGG:R00551 "KEGG reaction"
xref: METACYC:ARGINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20572 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_output_compound UPa:UPC00077 ! L-ornithine
relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_output_compound UPa:UPC00086 ! urea
relationship: part_of UPa:UER00270 {cardinality="1", direction="LR", order="1"} ! L-ornithine and urea from L-arginine: step 1/1
relationship: part_of UPa:UER00270 ! L-ornithine and urea from L-arginine: step 1/1

[Term]
id: UPa:UCR00552
name: H(2)O + L-arginine = L-citrulline + NH(3)
namespace: reaction
xref: KEGG:R00552 "KEGG reaction"
xref: METACYC:ARGININE-DEIMINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19600 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00327 ! L-citrulline
relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline
relationship: part_of UPa:UER00364 ! carbamoyl phosphate from L-arginine: step 1/2
relationship: part_of UPa:UER00364 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from L-arginine: step 1/2

[Term]
id: UPa:UCR00565
name: L-arginine + glycine = L-ornithine + guanidinoacetate
namespace: reaction
xref: KEGG:R00565 "KEGG reaction"
xref: METACYC:GLYCINE-AMIDINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13204 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_output_compound UPa:UPC00077 ! L-ornithine
relationship: has_output_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate
relationship: has_output_compound UPa:UPC00581 ! guanidinoacetate
relationship: part_of UPa:UER00579 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 1/2
relationship: part_of UPa:UER00579 ! creatine from L-arginine and glycine: step 1/2

[Term]
id: UPa:UCR00566
name: L-arginine = CO(2) + agmatine
namespace: reaction
xref: KEGG:R00566 "KEGG reaction"
xref: METACYC:ARGDECARBOX-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17644 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00179 {cardinality="1"} ! agmatine
relationship: has_output_compound UPa:UPC00179 ! agmatine
relationship: part_of UPa:UER00284 ! agmatine from L-arginine: step 1/1
relationship: part_of UPa:UER00284 {cardinality="1", direction="LR", order="1"} ! agmatine from L-arginine: step 1/1

[Term]
id: UPa:UCR00570
name: ATP + CDP = ADP + CTP
namespace: reaction
xref: KEGG:R00570 "KEGG reaction"
xref: METACYC:CDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25240 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00112 ! CDP
relationship: has_input_compound UPa:UPC00112 {cardinality="1"} ! CDP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_output_compound UPa:UPC00063 ! CTP
relationship: part_of UPa:UER00642 ! CTP from cytidine: step 3/3
relationship: part_of UPa:UER00642 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 3/3

[Term]
id: UPa:UCR00571
name: ATP + NH(3) + UTP = ADP + CTP + phosphate
namespace: reaction
xref: KEGG:R00571 "KEGG reaction"
xref: RHEA:16600 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP
relationship: has_input_compound UPa:UPC00075 ! UTP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_output_compound UPa:UPC00063 ! CTP
relationship: part_of UPa:UER00277 ! CTP from UDP: step 2/2
relationship: part_of UPa:UER00277 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 2/2

[Term]
id: UPa:UCR00575
name: 2 ATP + H(2)O + L-glutamine + bicarbonate = 2 ADP + L-glutamate + carbamoyl phosphate + phosphate
namespace: reaction
xref: KEGG:R00575 "KEGG reaction"
xref: METACYC:CARBPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18636 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00169 ! carbamoyl phosphate
relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate
relationship: part_of UPa:UER00115 ! (S)-dihydroorotate from bicarbonate: step 1/3
relationship: part_of UPa:UER00115 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 1/3
relationship: part_of UPa:UER00171 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from bicarbonate: step 1/1
relationship: part_of UPa:UER00171 ! carbamoyl phosphate from bicarbonate: step 1/1

[Term]
id: UPa:UCR00578
name: ATP + H(2)O + L-aspartate + L-glutamine = AMP + L-asparagine + L-glutamate + diphosphate
namespace: reaction
xref: KEGG:R00578 "KEGG reaction"
xref: METACYC:ASNSYNB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12231 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00152 ! L-asparagine
relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine
relationship: part_of UPa:UER00195 ! L-asparagine from L-aspartate (L-Gln route): step 1/1
relationship: part_of UPa:UER00195 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (L-Gln route): step 1/1

[Term]
id: UPa:UCR00582
name: H(2)O + O-phospho-L-serine = L-serine + phosphate
namespace: reaction
xref: KEGG:R00582 "KEGG reaction"
xref: METACYC:RXN0-5114 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21211 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine
relationship: has_input_compound UPa:UPC01005 ! O-phospho-L-serine
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00065 ! L-serine
relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: part_of UPa:UER00198 ! L-serine from 3-phospho-D-glycerate: step 3/3
relationship: part_of UPa:UER00198 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 3/3

[Term]
id: UPa:UCR00585
name: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
namespace: reaction
xref: KEGG:R00585 "KEGG reaction"
xref: METACYC:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22855 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_input_compound UPa:UPC00065 ! L-serine
relationship: has_output_compound UPa:UPC00041 ! L-alanine
relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate
relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate
relationship: part_of UPa:UER00915 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 2/4
relationship: part_of UPa:UER00915 ! 3-phospho-D-glycerate from glycine: step 2/4

[Term]
id: UPa:UCR00586
name: L-serine + acetyl-CoA = CoA + O-acetyl-L-serine
namespace: reaction
xref: KEGG:R00586 "KEGG reaction"
xref: METACYC:SERINE-O-ACETTRAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24563 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_input_compound UPa:UPC00065 ! L-serine
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00979 ! O-acetyl-L-serine
relationship: has_output_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine
relationship: part_of UPa:UER00199 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 1/2
relationship: part_of UPa:UER00199 ! L-cysteine from L-serine: step 1/2

[Term]
id: UPa:UCR00605
name: NAD(+) + methanol = H(+) + NADH + formaldehyde
namespace: reaction
xref: KEGG:R00605 "KEGG reaction"
xref: METACYC:METHANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19404 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00132 ! methanol
relationship: has_input_compound UPa:UPC00132 {cardinality="1"} ! methanol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_output_compound UPa:UPC00067 ! formaldehyde
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00893 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methanol: step 1/1
relationship: part_of UPa:UER00893 ! formaldehyde from methanol: step 1/1

[Term]
id: UPa:UCR00606
name: H(2)O + amicyanin + methylamine = 2 H(+) + NH(3) + formaldehyde + reduced amicyanin
namespace: reaction
xref: KEGG:R00606 "KEGG reaction"
xref: METACYC:RXN-2841 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:30210 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00218 ! methylamine
relationship: has_input_compound UPa:UPC00218 {cardinality="1"} ! methylamine
relationship: has_input_compound UPa:UPC19671 ! amicyanin
relationship: has_input_compound UPa:UPC19671 {cardinality="1"} ! amicyanin
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_output_compound UPa:UPC00067 ! formaldehyde
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC19672 ! reduced amicyanin
relationship: has_output_compound UPa:UPC19672 {cardinality="1"} ! reduced amicyanin
relationship: part_of UPa:UER00870 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methylamine: step 1/1
relationship: part_of UPa:UER00870 ! formaldehyde from methylamine: step 1/1

[Term]
id: UPa:UCR00611
name: H(2)O + electron-transferring flavoprotein + sarcosine = formaldehyde + glycine + reduced electron-transferring flavoprotein
namespace: reaction
xref: KEGG:R00611 "KEGG reaction"
xref: METACYC:SARCOSINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19796 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine
relationship: has_input_compound UPa:UPC00213 ! sarcosine
relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein
relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein
relationship: has_output_compound UPa:UPC00037 ! glycine
relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00067 ! formaldehyde
relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein
relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein
relationship: part_of UPa:UER00398 {cardinality="1", direction="LR", order="1"} ! formaldehyde and glycine from sarcosine: step 1/1
relationship: part_of UPa:UER00398 ! formaldehyde and glycine from sarcosine: step 1/1

[Term]
id: UPa:UCR00617
name: ATP + thiamine phosphate = ADP + thiamine diphosphate
namespace: reaction
xref: KEGG:R00617 "KEGG reaction"
xref: METACYC:THI-P-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15916 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC01081 ! thiamine phosphate
relationship: has_input_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate
relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate
relationship: part_of UPa:UER00142 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine phosphate: step 1/1
relationship: part_of UPa:UER00142 ! thiamine diphosphate from thiamine phosphate: step 1/1

[Term]
id: UPa:UCR00619
name: ATP + thiamine = AMP + thiamine diphosphate
namespace: reaction
xref: KEGG:R00619 "KEGG reaction"
xref: METACYC:THIAMIN-PYROPHOSPHOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11579 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine
relationship: has_input_compound UPa:UPC00378 ! thiamine
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate
relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate
relationship: part_of UPa:UER00597 ! thiamine diphosphate from thiamine: step 1/1
relationship: part_of UPa:UER00597 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine: step 1/1

[Term]
id: UPa:UCR00640
name: L-Galactono-1,4-lactone + 2 ferricytochrome c = 2 H(+) + L-ascorbate + 2 ferrocytochrome c
namespace: reaction
xref: KEGG:R00640 "KEGG reaction"
xref: METACYC:GALACTONOLACTONE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14760 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c
relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c
relationship: has_input_compound UPa:UPC01115 {cardinality="1"} ! L-Galactono-1,4-lactone
relationship: has_input_compound UPa:UPC01115 ! L-Galactono-1,4-lactone
relationship: has_output_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate
relationship: has_output_compound UPa:UPC00072 ! L-ascorbate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c
relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c
relationship: part_of UPa:UER00935 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 5/5
relationship: part_of UPa:UER00935 ! L-ascorbate from GDP-alpha-D-mannose: step 5/5

[Term]
id: UPa:UCR00647
name: L-ascorbate = L-xylo-hexulonolactone
namespace: reaction
xref: KEGG:R00647 "KEGG reaction"
xref: METACYC:RXN-8784 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15272 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00072 ! L-ascorbate
relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate
relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone
relationship: has_output_compound UPa:UPC03289 ! L-xylo-hexulonolactone
relationship: part_of UPa:UER00939 {cardinality="1", direction="RL", order="2"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4
relationship: part_of UPa:UER00939 ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4

[Term]
id: UPa:UCR00658
name: 2-phospho-D-glycerate = H(2)O + phosphoenolpyruvate
namespace: reaction
xref: KEGG:R00658 "KEGG reaction"
xref: METACYC:2PGADEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10167 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: part_of UPa:UER00187 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 4/5
relationship: part_of UPa:UER00187 ! pyruvate from D-glyceraldehyde 3-phosphate: step 4/5

[Term]
id: UPa:UCR00667
name: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde
namespace: reaction
xref: KEGG:R00667 "KEGG reaction"
xref: METACYC:ORNITHINE-GLU-AMINOTRANSFORASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25163 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00077 ! L-ornithine
relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde
relationship: part_of UPa:UER00358 ! L-glutamate 5-semialdehyde from L-ornithine: step 1/1
relationship: part_of UPa:UER00358 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-ornithine: step 1/1

[Term]
id: UPa:UCR00669
name: H(2)O + N(2)-acetyl-L-ornithine = L-ornithine + acetate
namespace: reaction
xref: KEGG:R00669 "KEGG reaction"
xref: METACYC:ACETYLORNDEACET-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15944 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine
relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_output_compound UPa:UPC00077 ! L-ornithine
relationship: part_of UPa:UER00110 {cardinality="1", direction="LR", order="1"} ! L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1
relationship: part_of UPa:UER00110 ! L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1

[Term]
id: UPa:UCR00670
name: L-ornithine = CO(2) + putrescine
namespace: reaction
xref: KEGG:R00670 "KEGG reaction"
xref: METACYC:ORNDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22967 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_input_compound UPa:UPC00077 ! L-ornithine
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00134 ! putrescine
relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: part_of UPa:UER00288 {cardinality="1", direction="LR", order="1"} ! putrescine from L-ornithine: step 1/1
relationship: part_of UPa:UER00288 ! putrescine from L-ornithine: step 1/1

[Term]
id: UPa:UCR00671
name: L-ornithine = L-proline + NH(3)
namespace: reaction
xref: KEGG:R00671 "KEGG reaction"
xref: METACYC:ORNITHINE-CYCLODEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24371 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_input_compound UPa:UPC00077 ! L-ornithine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00148 ! L-proline
relationship: has_output_compound UPa:UPC00148 {cardinality="1"} ! L-proline
relationship: part_of UPa:UER00357 ! L-proline from L-ornithine: step 1/1
relationship: part_of UPa:UER00357 {cardinality="1", direction="LR", order="1"} ! L-proline from L-ornithine: step 1/1

[Term]
id: UPa:UCR00673
name: H(2)O + L-tryptophan = NH(3) + indole + pyruvate
namespace: reaction
xref: KEGG:R00673 "KEGG reaction"
xref: METACYC:TRYPTOPHAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19556 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan
relationship: has_input_compound UPa:UPC00078 ! L-tryptophan
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole
relationship: has_output_compound UPa:UPC00463 ! indole
relationship: part_of UPa:UER00452 {cardinality="1", direction="LR", order="1"} ! indole and pyruvate from L-tryptophan: step 1/1
relationship: part_of UPa:UER00452 ! indole and pyruvate from L-tryptophan: step 1/1

[Term]
id: UPa:UCR00674
name: L-serine + indole = H(2)O + L-tryptophan
namespace: reaction
xref: KEGG:R00674 "KEGG reaction"
xref: METACYC:RXN0-2382 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26437 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_input_compound UPa:UPC00065 ! L-serine
relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole
relationship: has_input_compound UPa:UPC00463 ! indole
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00078 ! L-tryptophan
relationship: has_output_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan
relationship: part_of UPa:UER00044 ! L-tryptophan from chorismate: step 5/5
relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 5/5

[Term]
id: UPa:UCR00678
name: L-tryptophan + O(2) = N-formyl-N-kynurenine
namespace: reaction
xref: KEGG:R00678 "KEGG reaction"
xref: METACYC:RXN-8665 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24539 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00078 ! L-tryptophan
relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan
relationship: has_output_compound UPa:UPC02700 ! N-formyl-N-kynurenine
relationship: has_output_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine
relationship: part_of UPa:UER00453 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 1/2
relationship: part_of UPa:UER00453 ! L-kynurenine from L-tryptophan: step 1/2

[Term]
id: UPa:UCR00688
name: H(2)O + L-phenylalanine + NAD(+) = H(+) + NADH + NH(3) + phenylpyruvate
namespace: reaction
xref: KEGG:R00688 "KEGG reaction"
xref: METACYC:PHENYLALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21411 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine
relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate
relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate
relationship: part_of UPa:UER00346 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (PDH route): step 1/1
relationship: part_of UPa:UER00346 ! L-phenylalanine from phenylpyruvate (PDH route): step 1/1

[Term]
id: UPa:UCR00691
name: L-arogenate = CO(2) + H(2)O + L-phenylalanine
namespace: reaction
xref: KEGG:R00691 "KEGG reaction"
xref: METACYC:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12539 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00826 ! L-arogenate
relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_output_compound UPa:UPC00079 ! L-phenylalanine
relationship: part_of UPa:UER00344 ! L-phenylalanine from L-arogenate: step 1/1
relationship: part_of UPa:UER00344 {cardinality="1", direction="LR", order="1"} ! L-phenylalanine from L-arogenate: step 1/1

[Term]
id: UPa:UCR00694
name: 2-oxoglutarate + L-phenylalanine = L-glutamate + phenylpyruvate
namespace: reaction
xref: KEGG:R00694 "KEGG reaction"
xref: METACYC:PHEAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25155 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate
relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate
relationship: part_of UPa:UER00347 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (ArAT route): step 1/1
relationship: part_of UPa:UER00347 ! L-phenylalanine from phenylpyruvate (ArAT route): step 1/1

[Term]
id: UPa:UCR00697
name: L-phenylalanine = NH(3) + trans-cinnamate
namespace: reaction
xref: KEGG:R00697 "KEGG reaction"
xref: METACYC:PHENYLALANINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21387 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate
relationship: has_output_compound UPa:UPC00423 ! trans-cinnamate
relationship: part_of UPa:UER00725 ! trans-cinnamate from L-phenylalanine: step 1/1
relationship: part_of UPa:UER00725 {cardinality="1", direction="LR", order="1"} ! trans-cinnamate from L-phenylalanine: step 1/1

[Term]
id: UPa:UCR00699
name: L-phenylalanine = 2-phenylethylamine + CO(2)
namespace: reaction
xref: KEGG:R00699 "KEGG reaction"
xref: METACYC:PHENYLALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19720 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine
relationship: has_output_compound UPa:UPC05332 ! 2-phenylethylamine
relationship: part_of UPa:UER00722 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 1/3
relationship: part_of UPa:UER00722 ! phenylacetate from L-phenylalanine: step 1/3

[Term]
id: UPa:UCR00703
name: (S)-lactate + NAD(+) = H(+) + NADH + pyruvate
namespace: reaction
xref: KEGG:R00703 "KEGG reaction"
xref: METACYC:L-LACTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23447 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00186 {cardinality="1"} ! (S)-lactate
relationship: has_input_compound UPa:UPC00186 ! (S)-lactate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00611 {cardinality="1", direction="RL", order="1"} ! (S)-lactate from pyruvate: step 1/1
relationship: part_of UPa:UER00611 ! (S)-lactate from pyruvate: step 1/1

[Term]
id: UPa:UCR00705
name: 3-oxopropanoate + CoA + NAD(+) = CO(2) + H(+) + NADH + acetyl-CoA
namespace: reaction
xref: KEGG:R00705 "KEGG reaction"
xref: METACYC:RXN-2902 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22995 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate
relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00951 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00951 ! None

[Term]
id: UPa:UCR00706
name: 3-oxopropanoate + CoA + NADP(+) = CO(2) + H(+) + NADPH + acetyl-CoA
namespace: reaction
xref: KEGG:R00706 "KEGG reaction"
xref: METACYC:1.2.1.18-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22991 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate
relationship: has_input_compound UPa:UPC00222 ! 3-oxopropanoate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00952 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00952 ! None

[Term]
id: UPa:UCR00707
name: (S)-1-pyrroline-5-carboxylic acid + 2 H(2)O + NAD(+) = H(+) + L-glutamate + NADH
namespace: reaction
xref: KEGG:R00707 "KEGG reaction"
xref: METACYC:PYRROLINECARBDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: METACYC:RXN-11632 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:16420 "Rhea reaction"
xref: RHEA:24893 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_input_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: part_of UPa:UER00374 ! L-glutamate from L-proline: step 2/2
relationship: part_of UPa:UER00374 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 2/2

[Term]
id: UPa:UCR00709
name: NAD(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADH
namespace: reaction
xref: KEGG:R00709 "KEGG reaction"
xref: METACYC:ISOCITRATE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: METACYC:RXN-7969 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:23635 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate
relationship: has_input_compound UPa:UPC00311 ! isocitrate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00996 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1
relationship: part_of UPa:UER00996 ! 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1

[Term]
id: UPa:UCR00710
name: H(2)O + NAD(+) + acetaldehyde = H(+) + NADH + acetate
namespace: reaction
xref: KEGG:R00710 "KEGG reaction"
xref: METACYC:RXN66-3 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25297 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: has_input_compound UPa:UPC00084 ! acetaldehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00768 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 2/2
relationship: part_of UPa:UER00768 ! acetate from ethanol: step 2/2

[Term]
id: UPa:UCR00713
name: H(2)O + NAD(+) + succinate semialdehyde = H(+) + NADH + succinate
namespace: reaction
xref: KEGG:R00713 "KEGG reaction"
xref: METACYC:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13220 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde
relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER01003 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER01003 ! None

[Term]
id: UPa:UCR00714
name: H(2)O + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinate
namespace: reaction
xref: KEGG:R00714 "KEGG reaction"
xref: METACYC:SUCCSEMIALDDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13216 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde
relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER01004 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER01004 ! None

[Term]
id: UPa:UCR00715
name: H(2)O + NAD(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADH
namespace: reaction
xref: KEGG:R00715 "KEGG reaction"
xref: METACYC:1.5.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12443 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00449 ! saccharopine
relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00047 ! L-lysine
relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00034 ! L-lysine from L-alpha-aminoadipate (fungal route): step 3/3
relationship: part_of UPa:UER00034 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 3/3

[Term]
id: UPa:UCR00716
name: H(2)O + NADP(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADPH
namespace: reaction
xref: KEGG:R00716 "KEGG reaction"
xref: METACYC:1.5.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19376 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00449 ! saccharopine
relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00047 ! L-lysine
relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: part_of UPa:UER00835 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 1/6
relationship: part_of UPa:UER00835 ! glutaryl-CoA from L-lysine: step 1/6

[Term]
id: UPa:UCR00731
name: L-tyrosine + O(2) = H(2)O + L-dopa
namespace: reaction
xref: KEGG:R00731 "KEGG reaction"
xref: RHEA:34286 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00082 ! L-tyrosine
relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00355 {cardinality="1"} ! L-dopa
relationship: has_output_compound UPa:UPC00355 ! L-dopa
relationship: part_of UPa:UER00733 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 1/2
relationship: part_of UPa:UER00733 ! dopamine from L-tyrosine: step 1/2

[Term]
id: UPa:UCR00732
name: L-arogenate + NAD(+) = CO(2) + H(+) + L-tyrosine + NADH
namespace: reaction
xref: KEGG:R00732 "KEGG reaction"
xref: METACYC:CYCLOHEXADIENYL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12259 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate
relationship: has_input_compound UPa:UPC00826 ! L-arogenate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00082 ! L-tyrosine
relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine
relationship: part_of UPa:UER00959 ! L-tyrosine from L-arogenate (NAD(+) route): step 1/1
relationship: part_of UPa:UER00959 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NAD(+) route): step 1/1

[Term]
id: UPa:UCR00733
name: L-arogenate + NADP(+) = CO(2) + H(+) + L-tyrosine + NADPH
namespace: reaction
xref: KEGG:R00733 "KEGG reaction"
xref: METACYC:RXN-5682 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15420 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate
relationship: has_input_compound UPa:UPC00826 ! L-arogenate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00082 ! L-tyrosine
relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine
relationship: part_of UPa:UER00960 ! L-tyrosine from L-arogenate (NADP(+) route): step 1/1
relationship: part_of UPa:UER00960 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NADP(+) route): step 1/1

[Term]
id: UPa:UCR00734
name: 2-oxoglutarate + L-tyrosine = (4-hydroxyphenyl)pyruvate + L-glutamate
namespace: reaction
xref: KEGG:R00734 "KEGG reaction"
xref: METACYC:TYROSINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15096 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine
relationship: has_input_compound UPa:UPC00082 ! L-tyrosine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate
relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate
relationship: part_of UPa:UER00338 ! acetoacetate and fumarate from L-phenylalanine: step 2/6
relationship: part_of UPa:UER00338 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 2/6
relationship: part_of UPa:UER00350 ! L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1
relationship: part_of UPa:UER00350 {cardinality="1", direction="RL", order="1"} ! L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1

[Term]
id: UPa:UCR00742
name: ATP + acetyl-CoA + bicarbonate = ADP + malonyl-CoA + phosphate
namespace: reaction
xref: KEGG:R00742 "KEGG reaction"
xref: METACYC:ACETYL-COA-CARBOXYLTRANSFER-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11311 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA
relationship: has_output_compound UPa:UPC00083 ! malonyl-CoA
relationship: part_of UPa:UER00711 ! malonyl-CoA from acetyl-CoA: step 1/1
relationship: part_of UPa:UER00711 {cardinality="1", direction="LR", order="1"} ! malonyl-CoA from acetyl-CoA: step 1/1

[Term]
id: UPa:UCR00750
name: acetaldehyde + pyruvate = 4-hydroxy-2-oxopentanoate
namespace: reaction
xref: KEGG:R00750 "KEGG reaction"
xref: METACYC:MHPELY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22627 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00084 ! acetaldehyde
relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate
relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate
relationship: part_of UPa:UER00797 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4
relationship: part_of UPa:UER00797 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4
relationship: part_of UPa:UER00907 ! acetaldehyde and pyruvate from p-cumate: step 7/7
relationship: part_of UPa:UER00907 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 7/7

[Term]
id: UPa:UCR00751
name: L-threonine = acetaldehyde + glycine
namespace: reaction
xref: KEGG:R00751 "KEGG reaction"
xref: METACYC:THREONINE-ALDOLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19628 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00188 ! L-threonine
relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine
relationship: has_output_compound UPa:UPC00037 ! glycine
relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00084 ! acetaldehyde
relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: part_of UPa:UER00429 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and glycine from L-threonine: step 1/1
relationship: part_of UPa:UER00429 ! acetaldehyde and glycine from L-threonine: step 1/1

[Term]
id: UPa:UCR00754
name: NAD(+) + ethanol = H(+) + NADH + acetaldehyde
namespace: reaction
xref: KEGG:R00754 "KEGG reaction"
xref: METACYC:ALCOHOL-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25293 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00469 {cardinality="1"} ! ethanol
relationship: has_input_compound UPa:UPC00469 ! ethanol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00084 ! acetaldehyde
relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: part_of UPa:UER00767 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 1/2
relationship: part_of UPa:UER00767 ! acetate from ethanol: step 1/2

[Term]
id: UPa:UCR00756
name: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
namespace: reaction
xref: KEGG:R00756 "KEGG reaction"
xref: METACYC:6PFRUCTPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16112 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate
relationship: has_output_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate
relationship: part_of UPa:UER00182 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4
relationship: part_of UPa:UER00182 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4

[Term]
id: UPa:UCR00765
name: H(2)O + alpha-D-glucosamine 6-phosphate = D-fructose 6-phosphate + NH(3)
namespace: reaction
xref: KEGG:R00765 "KEGG reaction"
xref: METACYC:GLUCOSAMINE-6-P-DEAMIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12175 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate
relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: part_of UPa:UER00684 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 5/5
relationship: part_of UPa:UER00684 ! D-fructose 6-phosphate from N-acetylneuraminate: step 5/5

[Term]
id: UPa:UCR00766
name: D-fructose 6-phosphate + UDP-alpha-D-glucose = UDP + sucrose 6-phosphate
namespace: reaction
xref: KEGG:R00766 "KEGG reaction"
xref: METACYC:SUCROSE-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22175 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose
relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose
relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP
relationship: has_output_compound UPa:UPC00015 ! UDP
relationship: has_output_compound UPa:UPC02591 ! sucrose 6-phosphate
relationship: has_output_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate
relationship: part_of UPa:UER00545 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2
relationship: part_of UPa:UER00545 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2

[Term]
id: UPa:UCR00768
name: D-fructose 6-phosphate + L-glutamine = L-glutamate + alpha-D-glucosamine 6-phosphate
namespace: reaction
xref: KEGG:R00768 "KEGG reaction"
xref: METACYC:L-GLN-FRUCT-6-P-AMINOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13240 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: has_input_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate
relationship: part_of UPa:UER00528 {cardinality="1", direction="LR", order="1"} ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1
relationship: part_of UPa:UER00528 ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1

[Term]
id: UPa:UCR00771
name: D-glucose 6-phosphate = D-fructose 6-phosphate
namespace: reaction
xref: KEGG:R00771 "KEGG reaction"
xref: METACYC:PGLUCISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: METACYC:RXN-6182 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:11819 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate
relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate
relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: part_of UPa:UER00181 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4
relationship: part_of UPa:UER00181 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4

[Term]
id: UPa:UCR00772
name: D-mannose 6-phosphate = D-fructose 6-phosphate
namespace: reaction
xref: KEGG:R00772 "KEGG reaction"
xref: METACYC:MANNPISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12359 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate
relationship: has_input_compound UPa:UPC00275 ! D-mannose 6-phosphate
relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: part_of UPa:UER00423 {cardinality="1", direction="RL", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2
relationship: part_of UPa:UER00423 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2

[Term]
id: UPa:UCR00774
name: ATP + bicarbonate + urea = ADP + phosphate + urea-1-carboxylate
namespace: reaction
xref: KEGG:R00774 "KEGG reaction"
xref: METACYC:UREA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20899 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00086 ! urea
relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC01010 ! urea-1-carboxylate
relationship: has_output_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate
relationship: part_of UPa:UER00371 ! CO(2) and NH(3) from urea (allophanate route): step 1/2
relationship: part_of UPa:UER00371 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 1/2

[Term]
id: UPa:UCR00783
name: H(2)O + ferricytochrome c + nitric oxide = H(+) + ferrocytochrome c + nitrite
namespace: reaction
xref: KEGG:R00783 "KEGG reaction"
xref: METACYC:NITRITE-REDUCTASE-CYTOCHROME-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:15236 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c
relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c
relationship: has_input_compound UPa:UPC00533 ! nitric oxide
relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00088 {cardinality="1"} ! nitrite
relationship: has_output_compound UPa:UPC00088 ! nitrite
relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c
relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c
relationship: part_of UPa:UER00707 ! dinitrogen from nitrate: step 2/4
relationship: part_of UPa:UER00707 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 2/4

[Term]
id: UPa:UCR00798
name: H(2)O + acceptor + nitrite = nitrate + reduced acceptor
namespace: reaction
xref: KEGG:R00798 "KEGG reaction"
xref: METACYC:NITRATREDUCT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21071 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00088 ! nitrite
relationship: has_input_compound UPa:UPC00088 {cardinality="1"} ! nitrite
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00244 {cardinality="1"} ! nitrate
relationship: has_output_compound UPa:UPC00244 ! nitrate
relationship: part_of UPa:UER00706 ! dinitrogen from nitrate: step 1/4
relationship: part_of UPa:UER00706 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 1/4

[Term]
id: UPa:UCR00805
name: H(2)O + sucrose 6-phosphate = phosphate + sucrose
namespace: reaction
xref: KEGG:R00805 "KEGG reaction"
xref: METACYC:SUCROSE-PHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19292 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02591 ! sucrose 6-phosphate
relationship: has_input_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00089 ! sucrose
relationship: has_output_compound UPa:UPC00089 {cardinality="1"} ! sucrose
relationship: part_of UPa:UER00546 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2
relationship: part_of UPa:UER00546 ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2

[Term]
id: UPa:UCR00812
name: NAD(+) + cis-1,2-dihydrobenzene-1,2-diol = H(+) + NADH + catechol
namespace: reaction
xref: KEGG:R00812 "KEGG reaction"
xref: METACYC:1.3.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15460 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol
relationship: has_input_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol
relationship: has_output_compound UPa:UPC00090 ! catechol
relationship: part_of UPa:UER00392 ! catechol from benzene: step 2/2
relationship: part_of UPa:UER00392 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 2/2

[Term]
id: UPa:UCR00813
name: (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+) = CO(2) + H(+) + NADH + catechol
namespace: reaction
xref: KEGG:R00813 "KEGG reaction"
xref: METACYC:1.3.1.25-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11563 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid
relationship: has_input_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol
relationship: has_output_compound UPa:UPC00090 ! catechol
relationship: part_of UPa:UER00255 ! catechol from benzoate: step 2/2
relationship: part_of UPa:UER00255 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 2/2

[Term]
id: UPa:UCR00817
name: O(2) + catechol = cis,cis-muconate
namespace: reaction
xref: KEGG:R00817 "KEGG reaction"
xref: METACYC:CATECHOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23855 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00090 ! catechol
relationship: has_input_compound UPa:UPC00090 {cardinality="1"} ! catechol
relationship: has_output_compound UPa:UPC02480 ! cis,cis-muconate
relationship: has_output_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate
relationship: part_of UPa:UER00258 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3
relationship: part_of UPa:UER00258 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3

[Term]
id: UPa:UCR00823
name: H(+) + NADH + O(2) + anthranilate = CO(2) + NAD(+) + NH(3) + catechol
namespace: reaction
xref: KEGG:R00823 "KEGG reaction"
xref: RHEA:11079 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00108 ! anthranilate
relationship: has_input_compound UPa:UPC00108 {cardinality="1"} ! anthranilate
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol
relationship: has_output_compound UPa:UPC00090 ! catechol
relationship: part_of UPa:UER01026 ! catechol from anthranilate: step 1/1
relationship: part_of UPa:UER01026 {cardinality="1", direction="LR", order="1"} ! catechol from anthranilate: step 1/1

[Term]
id: UPa:UCR00829
name: acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA
namespace: reaction
xref: KEGG:R00829 "KEGG reaction"
xref: METACYC:RXN-3641 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19484 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC02232 ! 3-oxoadipyl-CoA
relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA
relationship: part_of UPa:UER00263 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2
relationship: part_of UPa:UER00263 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2

[Term]
id: UPa:UCR00830
name: glycine + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA
namespace: reaction
xref: KEGG:R00830 "KEGG reaction"
xref: METACYC:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12924 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00430 ! 5-aminolevulinate
relationship: has_output_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate
relationship: part_of UPa:UER00375 ! 5-aminolevulinate from glycine: step 1/1
relationship: part_of UPa:UER00375 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from glycine: step 1/1

[Term]
id: UPa:UCR00832
name: L-arginine + succinyl-CoA = CoA + N(2)-succinyl-L-arginine
namespace: reaction
xref: KEGG:R00832 "KEGG reaction"
xref: METACYC:ARGININE-N-SUCCINYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15188 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine
relationship: has_output_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine
relationship: part_of UPa:UER00279 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 1/5
relationship: part_of UPa:UER00279 ! L-glutamate and succinate from L-arginine: step 1/5

[Term]
id: UPa:UCR00833
name: (R)-methylmalonyl-CoA = succinyl-CoA
namespace: reaction
xref: KEGG:R00833 "KEGG reaction"
xref: METACYC:METHYLMALONYL-COA-MUT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22891 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA
relationship: has_input_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA
relationship: has_output_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: part_of UPa:UER00910 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 3/3
relationship: part_of UPa:UER00910 ! succinyl-CoA from propanoyl-CoA: step 3/3

[Term]
id: UPa:UCR00835
name: D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + H(+) + NADPH
namespace: reaction
xref: KEGG:R00835 "KEGG reaction"
xref: METACYC:RXN-14819 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:15844 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate
relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate
relationship: has_output_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate
relationship: part_of UPa:UER00408 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3
relationship: part_of UPa:UER00408 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3

[Term]
id: UPa:UCR00847
name: ATP + glycerol = ADP + sn-glycerol 3-phosphate
namespace: reaction
xref: KEGG:R00847 "KEGG reaction"
xref: METACYC:GLYCEROL-KIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21647 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00116 ! glycerol
relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate
relationship: has_output_compound UPa:UPC00093 ! sn-glycerol 3-phosphate
relationship: part_of UPa:UER00672 ! sn-glycerol 3-phosphate from glycerol: step 1/1
relationship: part_of UPa:UER00672 {cardinality="1", direction="LR", order="1"} ! sn-glycerol 3-phosphate from glycerol: step 1/1

[Term]
id: UPa:UCR00849
name: Quinone + sn-glycerol 3-phosphate = Hydroquinone + glycerone phosphate
namespace: reaction
xref: KEGG:R00849 "KEGG reaction"
xref: RHEA:18980 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate
relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate
relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone
relationship: has_input_compound UPa:UPC15602 ! Quinone
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone
relationship: has_output_compound UPa:UPC15603 ! Hydroquinone
relationship: part_of UPa:UER00673 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1
relationship: part_of UPa:UER00673 ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1
relationship: part_of UPa:UER00674 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1
relationship: part_of UPa:UER00674 ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1

[Term]
id: UPa:UCR00851
name: acyl-CoA + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + CoA
namespace: reaction
xref: KEGG:R00851 "KEGG reaction"
xref: METACYC:RXN-1381 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15328 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA
relationship: has_input_compound UPa:UPC00040 ! acyl-CoA
relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate
relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate
relationship: has_output_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate
relationship: part_of UPa:UER00612 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3
relationship: part_of UPa:UER00612 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

[Term]
id: UPa:UCR00858
name: 3 H(2)O + 3 NADP(+) + hydrogen sulfide = 3 H(+) + 3 NADPH + sulfite
namespace: reaction
xref: KEGG:R00858 "KEGG reaction"
xref: METACYC:SULFITE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13804 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: part_of UPa:UER00207 ! hydrogen sulfide from sulfite (NADPH route): step 1/1
relationship: part_of UPa:UER00207 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (NADPH route): step 1/1

[Term]
id: UPa:UCR00859
name: 3 H(2)O + hydrogen sulfide + 6 oxidized ferredoxin = 6 H(+) + 6 reduced ferredoxin + sulfite
namespace: reaction
xref: KEGG:R00859 "KEGG reaction"
xref: METACYC:SULFITE-REDUCTASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23135 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00139 ! oxidized ferredoxin
relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin
relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin
relationship: has_output_compound UPa:UPC00138 ! reduced ferredoxin
relationship: part_of UPa:UER00208 ! hydrogen sulfide from sulfite (ferredoxin route): step 1/1
relationship: part_of UPa:UER00208 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (ferredoxin route): step 1/1

[Term]
id: UPa:UCR00874
name: D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol
namespace: reaction
xref: KEGG:R00874 "KEGG reaction"
xref: METACYC:1.1.99.28-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20640 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00031 ! D-glucose
relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose
relationship: has_input_compound UPa:UPC00095 ! D-fructose
relationship: has_input_compound UPa:UPC00095 {cardinality="1"} ! D-fructose
relationship: has_output_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone
relationship: has_output_compound UPa:UPC00198 ! D-glucono-1,5-lactone
relationship: has_output_compound UPa:UPC00794 ! D-sorbitol
relationship: has_output_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol
relationship: part_of UPa:UER00784 {cardinality="1", direction="LR", order="1"} ! D-sorbitol from D-fructose and D-glucose: step 1/1
relationship: part_of UPa:UER00784 ! D-sorbitol from D-fructose and D-glucose: step 1/1

[Term]
id: UPa:UCR00883
name: GDP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + phosphate
namespace: reaction
xref: KEGG:R00883 "KEGG reaction"
xref: METACYC:MANNPGUANYLTRANGDP-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12908 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00035 ! GDP
relationship: has_input_compound UPa:UPC00035 {cardinality="1"} ! GDP
relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate
relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose
relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose
relationship: part_of UPa:UER00425 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1
relationship: part_of UPa:UER00425 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1

[Term]
id: UPa:UCR00885
name: GTP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + diphosphate
namespace: reaction
xref: KEGG:R00885 "KEGG reaction"
xref: METACYC:2.7.7.13-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15232 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate
relationship: has_input_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose
relationship: has_output_compound UPa:UPC00096 ! GDP-alpha-D-mannose
relationship: part_of UPa:UER00930 ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1
relationship: part_of UPa:UER00930 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1

[Term]
id: UPa:UCR00888
name: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O
namespace: reaction
xref: KEGG:R00888 "KEGG reaction"
xref: METACYC:GDPMANDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23823 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose
relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose
relationship: has_output_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose
relationship: part_of UPa:UER00190 ! GDP-L-fucose from GDP-alpha-D-mannose: step 1/2
relationship: part_of UPa:UER00190 {cardinality="1", direction="LR", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 1/2

[Term]
id: UPa:UCR00893
name: L-cysteine + O(2) = 3-sulfino-L-alanine
namespace: reaction
xref: KEGG:R00893 "KEGG reaction"
xref: METACYC:CYSTEINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20444 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_output_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine
relationship: has_output_compound UPa:UPC00606 ! 3-sulfino-L-alanine
relationship: part_of UPa:UER00537 ! hypotaurine from L-cysteine: step 1/2
relationship: part_of UPa:UER00537 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 1/2

[Term]
id: UPa:UCR00894
name: ATP + L-cysteine + L-glutamate = ADP + L-gamma-glutamyl-L-cysteine + phosphate
namespace: reaction
xref: KEGG:R00894 "KEGG reaction"
xref: METACYC:GLUTCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13288 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine
relationship: has_output_compound UPa:UPC00669 ! L-gamma-glutamyl-L-cysteine
relationship: part_of UPa:UER00209 ! glutathione from L-cysteine and L-glutamate: step 1/2
relationship: part_of UPa:UER00209 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 1/2

[Term]
id: UPa:UCR00897
name: O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate
namespace: reaction
xref: KEGG:R00897 "KEGG reaction"
xref: METACYC:ACSERLY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14832 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00979 ! O-acetyl-L-serine
relationship: has_input_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00097 ! L-cysteine
relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: part_of UPa:UER00200 ! L-cysteine from L-serine: step 2/2
relationship: part_of UPa:UER00200 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 2/2

[Term]
id: UPa:UCR00901
name: L-cysteine + sulfite = L-cysteate + hydrogen sulfide
namespace: reaction
xref: KEGG:R00901 "KEGG reaction"
xref: METACYC:CYSTEINE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20919 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00094 ! sulfite
relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_output_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_output_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_output_compound UPa:UPC00506 ! L-cysteate
relationship: has_output_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate
relationship: part_of UPa:UER00540 ! taurine from L-cysteine: step 1/2
relationship: part_of UPa:UER00540 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 1/2

[Term]
id: UPa:UCR00921
name: phosphate + propanoyl-CoA = CoA + propanoyl phosphate
namespace: reaction
xref: KEGG:R00921 "KEGG reaction"
xref: METACYC:PTAALT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28049 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA
relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate
relationship: has_output_compound UPa:UPC02876 ! propanoyl phosphate
relationship: part_of UPa:UER00509 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 3/4
relationship: part_of UPa:UER00509 ! propanoate from L-threonine: step 3/4

[Term]
id: UPa:UCR00939
name: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH
namespace: reaction
xref: KEGG:R00939 "KEGG reaction"
xref: METACYC:DIHYDROFOLATEREDUCT-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:15012 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate
relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate
relationship: part_of UPa:UER00158 ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1
relationship: part_of UPa:UER00158 {cardinality="1", direction="RL", order="1"} ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1

[Term]
id: UPa:UCR00944
name: 10-formyl-5,6,7,8-tetrahydrofolate + H(2)O = 5,6,7,8-tetrahydrofolate + formate
namespace: reaction
xref: KEGG:R00944 "KEGG reaction"
xref: METACYC:FORMYLTHFDEFORMYL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19836 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: part_of UPa:UER00170 {cardinality="1", direction="LR", order="1"} ! formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1
relationship: part_of UPa:UER00170 ! formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1

[Term]
id: UPa:UCR00945
name: 5,10-methylene-THF + H(2)O + glycine = 5,6,7,8-tetrahydrofolate + L-serine
namespace: reaction
xref: KEGG:R00945 "KEGG reaction"
xref: METACYC:GLYOHMETRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15484 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF
relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF
relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_output_compound UPa:UPC00065 ! L-serine
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: part_of UPa:UER00914 ! 3-phospho-D-glycerate from glycine: step 1/4
relationship: part_of UPa:UER00914 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 1/4
relationship: part_of UPa:UER01023 ! glycine from L-serine: step 1/1
relationship: part_of UPa:UER01023 {cardinality="1", direction="RL", order="1"} ! glycine from L-serine: step 1/1

[Term]
id: UPa:UCR00946
name: 5-methyl-THF + L-homocysteine = 5,6,7,8-tetrahydrofolate + L-methionine
namespace: reaction
xref: KEGG:R00946 "KEGG reaction"
xref: METACYC:HOMOCYSMETB12-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11175 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: has_input_compound UPa:UPC00155 ! L-homocysteine
relationship: has_input_compound UPa:UPC00440 ! 5-methyl-THF
relationship: has_input_compound UPa:UPC00440 {cardinality="1"} ! 5-methyl-THF
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: part_of UPa:UER00081 ! L-methionine from L-homocysteine (MetH route): step 1/1
relationship: part_of UPa:UER00081 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetH route): step 1/1

[Term]
id: UPa:UCR00956
name: CTP + alpha-D-glucose 1-phosphate = CDP-glucose + diphosphate
namespace: reaction
xref: KEGG:R00956 "KEGG reaction"
xref: METACYC:2.7.7.33-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18216 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00103 ! alpha-D-glucose 1-phosphate
relationship: has_input_compound UPa:UPC00103 {cardinality="1"} ! alpha-D-glucose 1-phosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose
relationship: has_output_compound UPa:UPC00501 ! CDP-glucose
relationship: part_of UPa:UER00511 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5
relationship: part_of UPa:UER00511 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5

[Term]
id: UPa:UCR00964
name: ATP + uridine = ADP + UMP
namespace: reaction
xref: KEGG:R00964 "KEGG reaction"
xref: METACYC:URIDINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16828 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine
relationship: has_input_compound UPa:UPC00299 ! uridine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00105 ! UMP
relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP
relationship: part_of UPa:UER00637 {cardinality="1", direction="LR", order="1"} ! UMP from uridine: step 1/1
relationship: part_of UPa:UER00637 ! UMP from uridine: step 1/1

[Term]
id: UPa:UCR00965
name: orotidine 5'-phosphate = CO(2) + UMP
namespace: reaction
xref: KEGG:R00965 "KEGG reaction"
xref: METACYC:OROTPDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11599 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate
relationship: has_input_compound UPa:UPC01103 ! orotidine 5'-phosphate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00105 ! UMP
relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP
relationship: part_of UPa:UER00120 ! UMP from orotate: step 2/2
relationship: part_of UPa:UER00120 {cardinality="1", direction="LR", order="1"} ! UMP from orotate: step 2/2

[Term]
id: UPa:UCR00966
name: UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
namespace: reaction
xref: KEGG:R00966 "KEGG reaction"
xref: METACYC:URACIL-PRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13020 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP
relationship: has_input_compound UPa:UPC00105 ! UMP
relationship: has_output_compound UPa:UPC00106 ! uracil
relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00636 {cardinality="1", direction="RL", order="1"} ! UMP from uracil: step 1/1
relationship: part_of UPa:UER00636 ! UMP from uracil: step 1/1

[Term]
id: UPa:UCR00974
name: H(2)O + cytosine = NH(3) + uracil
namespace: reaction
xref: KEGG:R00974 "KEGG reaction"
xref: METACYC:CYTDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20608 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00380 ! cytosine
relationship: has_input_compound UPa:UPC00380 {cardinality="1"} ! cytosine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil
relationship: has_output_compound UPa:UPC00106 ! uracil
relationship: part_of UPa:UER00635 ! uracil from cytosine: step 1/1
relationship: part_of UPa:UER00635 {cardinality="1", direction="LR", order="1"} ! uracil from cytosine: step 1/1

[Term]
id: UPa:UCR00976
name: H(2)O + acceptor + uracil = barbiturate + reduced acceptor
namespace: reaction
xref: KEGG:R00976 "KEGG reaction"
xref: METACYC:URACIL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22755 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00106 ! uracil
relationship: has_input_compound UPa:UPC00106 {cardinality="1"} ! uracil
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00813 {cardinality="1"} ! barbiturate
relationship: has_output_compound UPa:UPC00813 ! barbiturate
relationship: part_of UPa:UER00643 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 1/3
relationship: part_of UPa:UER00643 ! malonate and urea from uracil: step 1/3

[Term]
id: UPa:UCR00985
name: NH(3) + chorismate = H(2)O + anthranilate + pyruvate
namespace: reaction
xref: KEGG:R00985 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00251 ! chorismate
relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00108 ! anthranilate
relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate
relationship: part_of UPa:UER00040 ! L-tryptophan from chorismate: step 1/5
relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 1/5

[Term]
id: UPa:UCR00987
name: H(2)O + L-kynurenine = L-alanine + anthranilate
namespace: reaction
xref: KEGG:R00987 "KEGG reaction"
xref: METACYC:KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16816 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00328 ! L-kynurenine
relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine
relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00041 ! L-alanine
relationship: has_output_compound UPa:UPC00108 ! anthranilate
relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate
relationship: part_of UPa:UER00455 ! L-alanine and anthranilate from L-kynurenine: step 1/1
relationship: part_of UPa:UER00455 {cardinality="1", direction="LR", order="1"} ! L-alanine and anthranilate from L-kynurenine: step 1/1

[Term]
id: UPa:UCR00994
name: 2-oxobutanoate + CO(2) + H(+) + NADH = D-erythro-3-methylmalic acid + NAD(+)
namespace: reaction
xref: KEGG:R00994 "KEGG reaction"
xref: RHEA:32718 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate
relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid
relationship: has_output_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid
relationship: part_of UPa:UER00069 ! 2-oxobutanoate from pyruvate: step 3/3
relationship: part_of UPa:UER00069 {cardinality="1", direction="RL", order="1"} ! 2-oxobutanoate from pyruvate: step 3/3

[Term]
id: UPa:UCR00996
name: L-threonine = 2-oxobutanoate + NH(3)
namespace: reaction
xref: KEGG:R00996 "KEGG reaction"
xref: METACYC:THREDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22111 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine
relationship: has_input_compound UPa:UPC00188 ! L-threonine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate
relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate
relationship: part_of UPa:UER00054 ! 2-oxobutanoate from L-threonine: step 1/1
relationship: part_of UPa:UER00054 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from L-threonine: step 1/1
relationship: part_of UPa:UER00507 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 1/4
relationship: part_of UPa:UER00507 ! propanoate from L-threonine: step 1/4

[Term]
id: UPa:UCR01001
name: H(2)O + L-cystathionine = 2-oxobutanoate + L-cysteine + NH(3)
namespace: reaction
xref: KEGG:R01001 "KEGG reaction"
xref: METACYC:RXN-15130 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14008 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine
relationship: has_input_compound UPa:UPC02291 ! L-cystathionine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00097 ! L-cysteine
relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_output_compound UPa:UPC00109 ! 2-oxobutanoate
relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate
relationship: part_of UPa:UER00202 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 2/2
relationship: part_of UPa:UER00202 ! L-cysteine from L-homocysteine and L-serine: step 2/2

[Term]
id: UPa:UCR01011
name: ATP + glycerone = ADP + glycerone phosphate
namespace: reaction
xref: KEGG:R01011 "KEGG reaction"
xref: METACYC:GLYCERONE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15776 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00184 {cardinality="1"} ! glycerone
relationship: has_input_compound UPa:UPC00184 ! glycerone
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: part_of UPa:UER00669 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 2/2
relationship: part_of UPa:UER00669 ! glycerone phosphate from glycerol (oxidative route): step 2/2

[Term]
id: UPa:UCR01015
name: D-glyceraldehyde 3-phosphate = glycerone phosphate
namespace: reaction
xref: KEGG:R01015 "KEGG reaction"
xref: METACYC:TRIOSEPISOMERIZATION-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18588 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: part_of UPa:UER00189 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1
relationship: part_of UPa:UER00189 ! D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1

[Term]
id: UPa:UCR01021
name: ATP + choline = ADP + phosphocholine
namespace: reaction
xref: KEGG:R01021 "KEGG reaction"
xref: METACYC:CHOLINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12840 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_input_compound UPa:UPC00114 ! choline
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00588 ! phosphocholine
relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine
relationship: part_of UPa:UER00737 {cardinality="1", direction="LR", order="1"} ! phosphocholine from choline: step 1/1
relationship: part_of UPa:UER00737 ! phosphocholine from choline: step 1/1

[Term]
id: UPa:UCR01022
name: O(2) + choline = H(2)O(2) + betaine aldehyde
namespace: reaction
xref: KEGG:R01022 "KEGG reaction"
xref: METACYC:CHOLINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13508 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_input_compound UPa:UPC00114 ! choline
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde
relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde
relationship: part_of UPa:UER00384 {cardinality="1", direction="LR", order="1"} ! betaine from choline: step 1/1
relationship: part_of UPa:UER00384 ! betaine from choline: step 1/1

[Term]
id: UPa:UCR01025
name: acceptor + choline = betaine aldehyde + reduced acceptor
namespace: reaction
xref: KEGG:R01025 "KEGG reaction"
xref: METACYC:CHD-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17436 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00114 ! choline
relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde
relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde
relationship: part_of UPa:UER00385 ! betaine aldehyde from choline (cytochrome c reductase route): step 1/1
relationship: part_of UPa:UER00385 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (cytochrome c reductase route): step 1/1

[Term]
id: UPa:UCR01028
name: H(2)O + choline sulfate = choline + sulfate
namespace: reaction
xref: KEGG:R01028 "KEGG reaction"
xref: METACYC:CHOLINE-SULFATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20823 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00919 ! choline sulfate
relationship: has_input_compound UPa:UPC00919 {cardinality="1"} ! choline sulfate
relationship: has_output_compound UPa:UPC00059 ! sulfate
relationship: has_output_compound UPa:UPC00059 {cardinality="1"} ! sulfate
relationship: has_output_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_output_compound UPa:UPC00114 ! choline
relationship: part_of UPa:UER00431 {cardinality="1", direction="LR", order="1"} ! choline from choline sulfate: step 1/1
relationship: part_of UPa:UER00431 ! choline from choline sulfate: step 1/1

[Term]
id: UPa:UCR01034
name: NAD(+) + glycerol = H(+) + NADH + glycerone
namespace: reaction
xref: KEGG:R01034 "KEGG reaction"
xref: METACYC:GLYCDEH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13772 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol
relationship: has_input_compound UPa:UPC00116 ! glycerol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00184 {cardinality="1"} ! glycerone
relationship: has_output_compound UPa:UPC00184 ! glycerone
relationship: part_of UPa:UER00668 ! glycerone phosphate from glycerol (oxidative route): step 1/2
relationship: part_of UPa:UER00668 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 1/2

[Term]
id: UPa:UCR01047
name: glycerol = 3-hydroxypropanal + H(2)O
namespace: reaction
xref: KEGG:R01047 "KEGG reaction"
xref: METACYC:GLYCEROL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19768 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol
relationship: has_input_compound UPa:UPC00116 ! glycerol
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00969 ! 3-hydroxypropanal
relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal
relationship: part_of UPa:UER00670 ! propane-1,3-diol from glycerol (reductive route): step 1/2
relationship: part_of UPa:UER00670 {cardinality="1", direction="LR", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 1/2

[Term]
id: UPa:UCR01049
name: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP
namespace: reaction
xref: KEGG:R01049 "KEGG reaction"
xref: METACYC:PRPPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15612 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate
relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00172 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1
relationship: part_of UPa:UER00172 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1

[Term]
id: UPa:UCR01051
name: ATP + D-ribose = ADP + D-ribose 5-phosphate
namespace: reaction
xref: KEGG:R01051 "KEGG reaction"
xref: METACYC:RIBOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13700 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00121 ! D-ribose
relationship: has_input_compound UPa:UPC00121 {cardinality="1"} ! D-ribose
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate
relationship: part_of UPa:UER00889 {cardinality="1", direction="LR", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2
relationship: part_of UPa:UER00889 ! D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2

[Term]
id: UPa:UCR01056
name: D-ribose 5-phosphate = D-ribulose 5-phosphate
namespace: reaction
xref: KEGG:R01056 "KEGG reaction"
xref: METACYC:RIB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14660 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate
relationship: has_input_compound UPa:UPC00117 ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: part_of UPa:UER00412 ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1
relationship: part_of UPa:UER00412 {cardinality="1", direction="RL", order="1"} ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1

[Term]
id: UPa:UCR01057
name: alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
namespace: reaction
xref: KEGG:R01057 "KEGG reaction"
xref: METACYC:PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18796 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate
relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate
relationship: part_of UPa:UER00173 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3
relationship: part_of UPa:UER00173 {cardinality="1", direction="RL", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3

[Term]
id: UPa:UCR01061
name: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = 3-phospho-D-glyceroyl phosphate + H(+) + NADH
namespace: reaction
xref: KEGG:R01061 "KEGG reaction"
xref: METACYC:GAPOXNPHOSPHN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10303 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate
relationship: has_output_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate
relationship: part_of UPa:UER00184 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 1/5
relationship: part_of UPa:UER00184 ! pyruvate from D-glyceraldehyde 3-phosphate: step 1/5

[Term]
id: UPa:UCR01064
name: 6-phospho-2-dehydro-3-deoxy-D-galactonic acid = D-glyceraldehyde 3-phosphate + pyruvate
namespace: reaction
xref: KEGG:R01064 "KEGG reaction"
xref: METACYC:DEHYDDEOXPHOSGALACT-ALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24467 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid
relationship: has_input_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: part_of UPa:UER00520 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3
relationship: part_of UPa:UER00520 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3

[Term]
id: UPa:UCR01066
name: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
namespace: reaction
xref: KEGG:R01066 "KEGG reaction"
xref: METACYC:DEOXYRIBOSE-P-ALD-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12824 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate
relationship: has_input_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: has_output_compound UPa:UPC00084 ! acetaldehyde
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: part_of UPa:UER00468 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2
relationship: part_of UPa:UER00468 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2

[Term]
id: UPa:UCR01068
name: D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate
namespace: reaction
xref: KEGG:R01068 "KEGG reaction"
xref: METACYC:F16ALDOLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14732 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00354 ! D-fructose 1,6-bisphosphate
relationship: has_input_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: part_of UPa:UER00183 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4
relationship: part_of UPa:UER00183 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4

[Term]
id: UPa:UCR01069
name: D-tagatose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate
namespace: reaction
xref: KEGG:R01069 "KEGG reaction"
xref: METACYC:TAGAALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22951 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate
relationship: has_input_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: part_of UPa:UER00716 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2
relationship: part_of UPa:UER00716 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2

[Term]
id: UPa:UCR01071
name: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
namespace: reaction
xref: KEGG:R01071 "KEGG reaction"
xref: METACYC:ATPPHOSPHORIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18476 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP
relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP
relationship: has_output_compound UPa:UPC00002 ! ATP
relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00006 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9
relationship: part_of UPa:UER00006 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9

[Term]
id: UPa:UCR01072
name: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O + L-glutamine
namespace: reaction
xref: KEGG:R01072 "KEGG reaction"
xref: METACYC:PRPPAMIDOTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14908 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine
relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00064 ! L-glutamine
relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00124 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2
relationship: part_of UPa:UER00124 {cardinality="1", direction="RL", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2

[Term]
id: UPa:UCR01073
name: N-(5-phospho-beta-D-ribosyl)anthranilic acid + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate
namespace: reaction
xref: KEGG:R01073 "KEGG reaction"
xref: METACYC:PRTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11771 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid
relationship: has_input_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid
relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate
relationship: has_output_compound UPa:UPC00108 ! anthranilate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00041 {cardinality="1", direction="RL", order="1"} ! L-tryptophan from chorismate: step 2/5
relationship: part_of UPa:UER00041 ! L-tryptophan from chorismate: step 2/5

[Term]
id: UPa:UCR01078
name: 2 H(+) + 2 S-adenosyl-L-methionine + dethiobiotin + 2 e- + sulfur donor = 2 5'-deoxyadenosine + 2 L-methionine + biotin
namespace: reaction
xref: KEGG:R01078 "KEGG reaction"
xref: METACYC:2.8.1.6-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22063 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC01909 ! dethiobiotin
relationship: has_input_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin
relationship: has_input_compound UPa:UPC05359 ! e-
relationship: has_input_compound UPa:UPC05359 {cardinality="1"} ! e-
relationship: has_input_compound UPa:UPC17023 {cardinality="1"} ! sulfur donor
relationship: has_input_compound UPa:UPC17023 ! sulfur donor
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC00120 {cardinality="1"} ! biotin
relationship: has_output_compound UPa:UPC00120 ! biotin
relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine
relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine
relationship: part_of UPa:UER00162 ! biotin from 7,8-diaminononanoate: step 2/2
relationship: part_of UPa:UER00162 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 2/2

[Term]
id: UPa:UCR01080
name: H(2)O + uridine = D-ribose + uracil
namespace: reaction
xref: KEGG:R01080 "KEGG reaction"
xref: METACYC:URIDINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15580 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00299 ! uridine
relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine
relationship: has_output_compound UPa:UPC00106 ! uracil
relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil
relationship: has_output_compound UPa:UPC00121 ! D-ribose
relationship: has_output_compound UPa:UPC00121 {cardinality="1"} ! D-ribose
relationship: part_of UPa:UER00634 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (hydrolase route): step 1/1
relationship: part_of UPa:UER00634 ! uracil from uridine (hydrolase route): step 1/1

[Term]
id: UPa:UCR01082
name: (S)-malate = H(2)O + fumarate
namespace: reaction
xref: KEGG:R01082 "KEGG reaction"
xref: METACYC:FUMHYDR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12463 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00149 ! (S)-malate
relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: part_of UPa:UER01007 {cardinality="1", direction="RL", order="1"} ! (S)-malate from fumarate: step 1/1
relationship: part_of UPa:UER01007 ! (S)-malate from fumarate: step 1/1

[Term]
id: UPa:UCR01083
name: N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate
namespace: reaction
xref: KEGG:R01083 "KEGG reaction"
xref: METACYC:AMPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16856 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP
relationship: has_input_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: part_of UPa:UER00336 ! AMP from IMP: step 2/2
relationship: part_of UPa:UER00336 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 2/2

[Term]
id: UPa:UCR01086
name: (N(omega)-L-arginino)succinate = L-arginine + fumarate
namespace: reaction
xref: KEGG:R01086 "KEGG reaction"
xref: METACYC:ARGSUCCINLYA-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24023 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate
relationship: has_input_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate
relationship: has_output_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_output_compound UPa:UPC00062 ! L-arginine
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: part_of UPa:UER00114 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 3/3
relationship: part_of UPa:UER00114 ! L-arginine from L-ornithine and carbamoyl phosphate: step 3/3
relationship: part_of UPa:UER00273 ! L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1
relationship: part_of UPa:UER00273 {cardinality="1", direction="LR", order="1"} ! L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1

[Term]
id: UPa:UCR01088
name: H(2)O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH(3)
namespace: reaction
xref: KEGG:R01088 "KEGG reaction"
xref: METACYC:LEUCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12223 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine
relationship: has_input_compound UPa:UPC00123 ! L-leucine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate
relationship: part_of UPa:UER00858 ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1
relationship: part_of UPa:UER00858 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1

[Term]
id: UPa:UCR01090
name: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate
namespace: reaction
xref: KEGG:R01090 "KEGG reaction"
xref: METACYC:BRANCHED-CHAINAMINOTRANSFERLEU-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18324 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00123 ! L-leucine
relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate
relationship: part_of UPa:UER00073 ! L-leucine from 3-methyl-2-oxobutanoate: step 4/4
relationship: part_of UPa:UER00073 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 4/4
relationship: part_of UPa:UER00857 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1
relationship: part_of UPa:UER00857 ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1

[Term]
id: UPa:UCR01121
name: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + isopentenyl diphosphate + phosphate
namespace: reaction
xref: KEGG:R01121 "KEGG reaction"
xref: METACYC:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23735 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate
relationship: has_input_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: part_of UPa:UER00100 ! isopentenyl diphosphate from (R)-mevalonate: step 3/3
relationship: part_of UPa:UER00100 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 3/3

[Term]
id: UPa:UCR01123
name: isopentenyl diphosphate = dimethylallyl diphosphate
namespace: reaction
xref: KEGG:R01123 "KEGG reaction"
xref: METACYC:IPPISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23287 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: has_output_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate
relationship: has_output_compound UPa:UPC00235 ! dimethylallyl diphosphate
relationship: part_of UPa:UER00104 ! dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1
relationship: part_of UPa:UER00104 {cardinality="1", direction="LR", order="1"} ! dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1

[Term]
id: UPa:UCR01127
name: H(2)O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
namespace: reaction
xref: KEGG:R01127 "KEGG reaction"
xref: METACYC:IMPCYCLOHYDROLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18448 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00130 ! IMP
relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00135 {cardinality="1", direction="RL", order="1"} ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1
relationship: part_of UPa:UER00135 ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1

[Term]
id: UPa:UCR01130
name: H(2)O + IMP + NAD(+) = H(+) + NADH + XMP
namespace: reaction
xref: KEGG:R01130 "KEGG reaction"
xref: METACYC:IMP-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11711 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: has_input_compound UPa:UPC00130 ! IMP
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00655 ! XMP
relationship: has_output_compound UPa:UPC00655 {cardinality="1"} ! XMP
relationship: part_of UPa:UER00295 ! XMP from IMP: step 1/1
relationship: part_of UPa:UER00295 {cardinality="1", direction="LR", order="1"} ! XMP from IMP: step 1/1

[Term]
id: UPa:UCR01131
name: ATP + inosine = ADP + IMP
namespace: reaction
xref: KEGG:R01131 "KEGG reaction"
xref: METACYC:INOSINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21143 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00294 ! inosine
relationship: has_input_compound UPa:UPC00294 {cardinality="1"} ! inosine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: has_output_compound UPa:UPC00130 ! IMP
relationship: part_of UPa:UER00647 ! IMP from inosine: step 1/1
relationship: part_of UPa:UER00647 {cardinality="1", direction="LR", order="1"} ! IMP from inosine: step 1/1

[Term]
id: UPa:UCR01132
name: IMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
namespace: reaction
xref: KEGG:R01132 "KEGG reaction"
xref: METACYC:HYPOXANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17976 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: has_input_compound UPa:UPC00130 ! IMP
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine
relationship: has_output_compound UPa:UPC00262 ! hypoxanthine
relationship: part_of UPa:UER00648 {cardinality="1", direction="RL", order="1"} ! IMP from hypoxanthine: step 1/1
relationship: part_of UPa:UER00648 ! IMP from hypoxanthine: step 1/1

[Term]
id: UPa:UCR01135
name: GTP + IMP + L-aspartate = GDP + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
namespace: reaction
xref: KEGG:R01135 "KEGG reaction"
xref: METACYC:ADENYLOSUCCINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15756 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP
relationship: has_input_compound UPa:UPC00130 ! IMP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00035 ! GDP
relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP
relationship: has_output_compound UPa:UPC03794 ! N(6)-(1,2-dicarboxyethyl)-AMP
relationship: has_output_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP
relationship: part_of UPa:UER00335 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 1/2
relationship: part_of UPa:UER00335 ! AMP from IMP: step 1/2

[Term]
id: UPa:UCR01151
name: H(2)O + O(2) + putrescine = 4-aminobutanal + H(2)O(2) + NH(3)
namespace: reaction
xref: KEGG:R01151 "KEGG reaction"
xref: METACYC:PUTRESCINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18276 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal
relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal
relationship: part_of UPa:UER00289 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (amine oxidase route): step 1/1
relationship: part_of UPa:UER00289 ! 4-aminobutanal from putrescine (amine oxidase route): step 1/1

[Term]
id: UPa:UCR01152
name: H(2)O + N-carbamoylputrescine = CO(2) + NH(3) + putrescine
namespace: reaction
xref: KEGG:R01152 "KEGG reaction"
xref: METACYC:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22287 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine
relationship: has_input_compound UPa:UPC00436 ! N-carbamoylputrescine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_output_compound UPa:UPC00134 ! putrescine
relationship: part_of UPa:UER00286 {cardinality="1", direction="LR", order="1"} ! putrescine from N-carbamoylputrescine (amidase route): step 1/1
relationship: part_of UPa:UER00286 ! putrescine from N-carbamoylputrescine (amidase route): step 1/1

[Term]
id: UPa:UCR01154
name: acetyl-CoA + putrescine = CoA + N-acetylputrescine
namespace: reaction
xref: KEGG:R01154 "KEGG reaction"
xref: METACYC:RXN-0 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25184 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC02714 {cardinality="1"} ! N-acetylputrescine
relationship: has_output_compound UPa:UPC02714 ! N-acetylputrescine
relationship: part_of UPa:UER00363 ! N-acetylputrescine from putrescine: step 1/1
relationship: part_of UPa:UER00363 {cardinality="1", direction="LR", order="1"} ! N-acetylputrescine from putrescine: step 1/1

[Term]
id: UPa:UCR01155
name: 2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate
namespace: reaction
xref: KEGG:R01155 "KEGG reaction"
xref: METACYC:PUTTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23819 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal
relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal
relationship: part_of UPa:UER00290 ! 4-aminobutanal from putrescine (transaminase route): step 1/1
relationship: part_of UPa:UER00290 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (transaminase route): step 1/1

[Term]
id: UPa:UCR01157
name: H(2)O + agmatine = putrescine + urea
namespace: reaction
xref: KEGG:R01157 "KEGG reaction"
xref: METACYC:AGMATIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13932 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine
relationship: has_input_compound UPa:UPC00179 ! agmatine
relationship: has_output_compound UPa:UPC00086 ! urea
relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_output_compound UPa:UPC00134 ! putrescine
relationship: part_of UPa:UER00287 ! putrescine from agmatine: step 1/1
relationship: part_of UPa:UER00287 {cardinality="1", direction="LR", order="1"} ! putrescine from agmatine: step 1/1

[Term]
id: UPa:UCR01158
name: H(2)O + L-histidinol + 2 NAD(+) = 2 H(+) + L-histidine + 2 NADH
namespace: reaction
xref: KEGG:R01158 "KEGG reaction"
xref: METACYC:RXN-8001 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20644 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00860 ! L-histidinol
relationship: has_input_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00135 {cardinality="1"} ! L-histidine
relationship: has_output_compound UPa:UPC00135 ! L-histidine
relationship: part_of UPa:UER00014 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9
relationship: part_of UPa:UER00014 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9

[Term]
id: UPa:UCR01167
name: L-histidine = CO(2) + histamine
namespace: reaction
xref: KEGG:R01167 "KEGG reaction"
xref: METACYC:HISTIDINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20843 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine
relationship: has_input_compound UPa:UPC00135 ! L-histidine
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00388 ! histamine
relationship: has_output_compound UPa:UPC00388 {cardinality="1"} ! histamine
relationship: part_of UPa:UER00786 ! histamine from L-histidine: step 1/1
relationship: part_of UPa:UER00786 {cardinality="1", direction="LR", order="1"} ! histamine from L-histidine: step 1/1

[Term]
id: UPa:UCR01168
name: L-histidine = NH(3) + trans-urocanate
namespace: reaction
xref: KEGG:R01168 "KEGG reaction"
xref: METACYC:HISTIDINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21235 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00135 ! L-histidine
relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00785 ! trans-urocanate
relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate
relationship: part_of UPa:UER00549 ! N-formimidoyl-L-glutamate from L-histidine: step 1/3
relationship: part_of UPa:UER00549 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 1/3

[Term]
id: UPa:UCR01183
name: NAD(+) + myo-inositol = H(+) + NADH + scyllo-inosose
namespace: reaction
xref: KEGG:R01183 "KEGG reaction"
xref: METACYC:MYO-INOSITOL-2-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16952 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00137 ! myo-inositol
relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose
relationship: has_output_compound UPa:UPC00691 ! scyllo-inosose
relationship: part_of UPa:UER00143 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 1/7
relationship: part_of UPa:UER00143 ! acetyl-CoA from myo-inositol: step 1/7

[Term]
id: UPa:UCR01184
name: O(2) + myo-inositol = D-glucuronate + H(2)O
namespace: reaction
xref: KEGG:R01184 "KEGG reaction"
xref: METACYC:MYO-INOSITOL-OXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23699 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00137 ! myo-inositol
relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00191 ! D-glucuronate
relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate
relationship: part_of UPa:UER00527 ! D-glucuronate from myo-inositol: step 1/1
relationship: part_of UPa:UER00527 {cardinality="1", direction="LR", order="1"} ! D-glucuronate from myo-inositol: step 1/1

[Term]
id: UPa:UCR01187
name: 1D-myo-inositol 3-phosphate + H(2)O = myo-inositol + phosphate
namespace: reaction
xref: KEGG:R01187 "KEGG reaction"
xref: METACYC:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:30742 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate
relationship: has_input_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00137 ! myo-inositol
relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol
relationship: part_of UPa:UER00788 ! myo-inositol from D-glucose 6-phosphate: step 2/2
relationship: part_of UPa:UER00788 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 2/2

[Term]
id: UPa:UCR01197
name: CO(2) + 2 H(+) + 2 reduced ferredoxin + succinyl-CoA = 2-oxoglutarate + CoA + 2 oxidized ferredoxin
namespace: reaction
xref: KEGG:R01197 "KEGG reaction"
xref: METACYC:2-OXOGLUTARATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17300 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin
relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin
relationship: part_of UPa:UER00998 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1
relationship: part_of UPa:UER00998 ! succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1

[Term]
id: UPa:UCR01213
name: (2S)-2-isopropylmalate + CoA = 3-methyl-2-oxobutanoate + H(2)O + acetyl-CoA
namespace: reaction
xref: KEGG:R01213 "KEGG reaction"
xref: METACYC:2-ISOPROPYLMALATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21527 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC02504 ! (2S)-2-isopropylmalate
relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate
relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate
relationship: part_of UPa:UER00070 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 1/4
relationship: part_of UPa:UER00070 ! L-leucine from 3-methyl-2-oxobutanoate: step 1/4

[Term]
id: UPa:UCR01214
name: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate
namespace: reaction
xref: KEGG:R01214 "KEGG reaction"
xref: METACYC:BRANCHED-CHAINAMINOTRANSFERVAL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24816 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine
relationship: has_input_compound UPa:UPC00183 ! L-valine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate
relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate
relationship: part_of UPa:UER00062 {cardinality="1", direction="RL", order="1"} ! L-valine from pyruvate: step 4/4
relationship: part_of UPa:UER00062 ! L-valine from pyruvate: step 4/4

[Term]
id: UPa:UCR01226
name: 3-methyl-2-oxobutanoate + 5,10-methylene-THF + H(2)O = 2-dehydropantoate + 5,6,7,8-tetrahydrofolate
namespace: reaction
xref: KEGG:R01226 "KEGG reaction"
xref: METACYC:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11827 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate
relationship: has_input_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate
relationship: has_input_compound UPa:UPC00143 ! 5,10-methylene-THF
relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00966 ! 2-dehydropantoate
relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate
relationship: part_of UPa:UER00003 {cardinality="1", direction="LR", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2
relationship: part_of UPa:UER00003 ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2

[Term]
id: UPa:UCR01229
name: GMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
namespace: reaction
xref: KEGG:R01229 "KEGG reaction"
xref: METACYC:GUANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25427 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP
relationship: has_input_compound UPa:UPC00144 ! GMP
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00242 ! guanine
relationship: has_output_compound UPa:UPC00242 {cardinality="1"} ! guanine
relationship: part_of UPa:UER00887 ! GMP from guanine: step 1/1
relationship: part_of UPa:UER00887 {cardinality="1", direction="RL", order="1"} ! GMP from guanine: step 1/1

[Term]
id: UPa:UCR01230
name: ATP + NH(3) + XMP = AMP + GMP + diphosphate
namespace: reaction
xref: KEGG:R01230 "KEGG reaction"
xref: METACYC:GMP-SYN-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18304 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP
relationship: has_input_compound UPa:UPC00655 ! XMP
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00144 ! GMP
relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP
relationship: part_of UPa:UER00297 ! GMP from XMP (ammonia route): step 1/1
relationship: part_of UPa:UER00297 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (ammonia route): step 1/1

[Term]
id: UPa:UCR01231
name: ATP + H(2)O + L-glutamine + XMP = AMP + GMP + L-glutamate + diphosphate
namespace: reaction
xref: KEGG:R01231 "KEGG reaction"
xref: METACYC:GMP-SYN-GLUT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11683 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP
relationship: has_input_compound UPa:UPC00655 ! XMP
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00144 ! GMP
relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP
relationship: part_of UPa:UER00296 ! GMP from XMP (L-Gln route): step 1/1
relationship: part_of UPa:UER00296 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (L-Gln route): step 1/1

[Term]
id: UPa:UCR01234
name: 3',5'-cyclic GMP + H(2)O = GMP
namespace: reaction
xref: KEGG:R01234 "KEGG reaction"
xref: METACYC:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16960 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00942 {cardinality="1"} ! 3',5'-cyclic GMP
relationship: has_input_compound UPa:UPC00942 ! 3',5'-cyclic GMP
relationship: has_output_compound UPa:UPC00144 ! GMP
relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP
relationship: part_of UPa:UER00748 ! GMP from 3',5'-cyclic GMP: step 1/1
relationship: part_of UPa:UER00748 {cardinality="1", direction="LR", order="1"} ! GMP from 3',5'-cyclic GMP: step 1/1

[Term]
id: UPa:UCR01248
name: L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylic acid + H(+) + NADH
namespace: reaction
xref: KEGG:R01248 "KEGG reaction"
xref: RHEA:14108 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00148 ! L-proline
relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid
relationship: part_of UPa:UER00361 {cardinality="1", direction="RL", order="2"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1
relationship: part_of UPa:UER00361 ! L-proline from L-glutamate 5-semialdehyde: step 1/1

[Term]
id: UPa:UCR01253
name: L-proline + Quinone = (S)-1-pyrroline-5-carboxylic acid + Hydroquinone
namespace: reaction
xref: KEGG:R01253 "KEGG reaction"
xref: METACYC:RXN-14903 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23787 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline
relationship: has_input_compound UPa:UPC00148 ! L-proline
relationship: has_input_compound UPa:UPC15602 ! Quinone
relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone
relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone
relationship: has_output_compound UPa:UPC15603 ! Hydroquinone
relationship: part_of UPa:UER00373 ! L-glutamate from L-proline: step 1/2
relationship: part_of UPa:UER00373 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 1/2

[Term]
id: UPa:UCR01268
name: H(2)O + nicotinamide = NH(3) + nicotinate
namespace: reaction
xref: KEGG:R01268 "KEGG reaction"
xref: METACYC:NICOTINAMID-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14548 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00153 ! nicotinamide
relationship: has_input_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate
relationship: has_output_compound UPa:UPC00253 ! nicotinate
relationship: part_of UPa:UER00790 ! nicotinate from nicotinamide: step 1/1
relationship: part_of UPa:UER00790 {cardinality="1", direction="LR", order="1"} ! nicotinate from nicotinamide: step 1/1

[Term]
id: UPa:UCR01271
name: diphosphate + nicotinamide D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide
namespace: reaction
xref: KEGG:R01271 "KEGG reaction"
xref: METACYC:2.4.2.12-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16152 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00455 ! nicotinamide D-ribonucleotide
relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide
relationship: has_output_compound UPa:UPC00153 ! nicotinamide
relationship: part_of UPa:UER00890 ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1
relationship: part_of UPa:UER00890 {cardinality="1", direction="RL", order="1"} ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1

[Term]
id: UPa:UCR01286
name: H(2)O + L-cystathionine = L-homocysteine + NH(3) + pyruvate
namespace: reaction
xref: KEGG:R01286 "KEGG reaction"
xref: METACYC:CYSTATHIONINE-BETA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13968 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02291 ! L-cystathionine
relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00155 ! L-homocysteine
relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: part_of UPa:UER00078 ! L-homocysteine from L-cystathionine: step 1/1
relationship: part_of UPa:UER00078 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from L-cystathionine: step 1/1

[Term]
id: UPa:UCR01287
name: O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate
namespace: reaction
xref: KEGG:R01287 "KEGG reaction"
xref: METACYC:ACETYLHOMOSER-CYS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:27825 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine
relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00155 ! L-homocysteine
relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: part_of UPa:UER00079 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-acetyl-L-homoserine: step 1/1
relationship: part_of UPa:UER00079 ! L-homocysteine from O-acetyl-L-homoserine: step 1/1

[Term]
id: UPa:UCR01288
name: O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate
namespace: reaction
xref: KEGG:R01288 "KEGG reaction"
xref: METACYC:RXN-9384 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:27829 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide
relationship: has_input_compound UPa:UPC00283 ! hydrogen sulfide
relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine
relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00155 ! L-homocysteine
relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: part_of UPa:UER00449 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-succinyl-L-homoserine: step 1/1
relationship: part_of UPa:UER00449 ! L-homocysteine from O-succinyl-L-homoserine: step 1/1

[Term]
id: UPa:UCR01290
name: L-homocysteine + L-serine = H(2)O + L-cystathionine
namespace: reaction
xref: KEGG:R01290 "KEGG reaction"
xref: METACYC:CYSTATHIONINE-BETA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10115 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_input_compound UPa:UPC00065 ! L-serine
relationship: has_input_compound UPa:UPC00155 ! L-homocysteine
relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine
relationship: has_output_compound UPa:UPC02291 ! L-cystathionine
relationship: part_of UPa:UER00201 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 1/2
relationship: part_of UPa:UER00201 ! L-cysteine from L-homocysteine and L-serine: step 1/2

[Term]
id: UPa:UCR01295
name: H(+) + NADPH + O(2) + benzoate = 4-hydroxybenzoate + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R01295 "KEGG reaction"
xref: METACYC:BENZOATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18036 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate
relationship: has_input_compound UPa:UPC00180 ! benzoate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate
relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate
relationship: part_of UPa:UER00256 ! 3,4-dihydroxybenzoate from benzoate: step 1/2
relationship: part_of UPa:UER00256 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 1/2

[Term]
id: UPa:UCR01298
name: 4-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R01298 "KEGG reaction"
xref: METACYC:1.14.13.33-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: METACYC:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19480 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate
relationship: has_input_compound UPa:UPC00156 ! 4-hydroxybenzoate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: part_of UPa:UER00257 ! 3,4-dihydroxybenzoate from benzoate: step 2/2
relationship: part_of UPa:UER00257 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 2/2

[Term]
id: UPa:UCR01301
name: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA
namespace: reaction
xref: KEGG:R01301 "KEGG reaction"
xref: METACYC:3.1.2.23-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11951 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA
relationship: has_input_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate
relationship: has_output_compound UPa:UPC00156 ! 4-hydroxybenzoate
relationship: part_of UPa:UER01022 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3
relationship: part_of UPa:UER01022 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3

[Term]
id: UPa:UCR01321
name: 1,2-diacyl-sn-glycerol + CDP-choline = CMP + phosphatidylcholine
namespace: reaction
xref: KEGG:R01321 "KEGG reaction"
xref: METACYC:RXN-5781 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10311 "Rhea reaction"
xref: RHEA:32942 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00307 ! CDP-choline
relationship: has_input_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline
relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol
relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine
relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine
relationship: part_of UPa:UER00740 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 2/2
relationship: part_of UPa:UER00740 ! phosphatidylcholine from phosphocholine: step 2/2

[Term]
id: UPa:UCR01325
name: citrate = H(2)O + cis-aconitate
namespace: reaction
xref: KEGG:R01325 "KEGG reaction"
xref: METACYC:ACONITATEDEHYDR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10231 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00158 ! citrate
relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00417 ! cis-aconitate
relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate
relationship: part_of UPa:UER00718 ! isocitrate from oxaloacetate: step 2/2
relationship: part_of UPa:UER00718 {cardinality="1", direction="LR", order="1"} ! isocitrate from oxaloacetate: step 2/2

[Term]
id: UPa:UCR01334
name: 2-phosphoglycolate + H(2)O = glycolate + phosphate
namespace: reaction
xref: KEGG:R01334 "KEGG reaction"
xref: METACYC:GPH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14372 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00988 {cardinality="1"} ! 2-phosphoglycolate
relationship: has_input_compound UPa:UPC00988 ! 2-phosphoglycolate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00160 ! glycolate
relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate
relationship: part_of UPa:UER00834 ! glycolate from 2-phosphoglycolate: step 1/1
relationship: part_of UPa:UER00834 {cardinality="1", direction="LR", order="1"} ! glycolate from 2-phosphoglycolate: step 1/1
relationship: part_of UPa:UER00911 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 1/3
relationship: part_of UPa:UER00911 ! glycine from 2-phosphoglycolate: step 1/3

[Term]
id: UPa:UCR01353
name: ATP + propanoate = ADP + propanoyl phosphate
namespace: reaction
xref: KEGG:R01353 "KEGG reaction"
xref: METACYC:PROPKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23151 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00163 ! propanoate
relationship: has_input_compound UPa:UPC00163 {cardinality="1"} ! propanoate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate
relationship: has_output_compound UPa:UPC02876 ! propanoyl phosphate
relationship: part_of UPa:UER00510 {cardinality="1", direction="RL", order="1"} ! propanoate from L-threonine: step 4/4
relationship: part_of UPa:UER00510 ! propanoate from L-threonine: step 4/4

[Term]
id: UPa:UCR01355
name: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate
namespace: reaction
xref: KEGG:R01355 "KEGG reaction"
xref: METACYC:23-DIMETHYLMALATE-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10475 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate
relationship: has_input_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00163 ! propanoate
relationship: has_output_compound UPa:UPC00163 {cardinality="1"} ! propanoate
relationship: part_of UPa:UER01019 ! propanoate and pyruvate from 6-hydroxynicotinate: step 8/8
relationship: part_of UPa:UER01019 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 8/8

[Term]
id: UPa:UCR01360
name: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
namespace: reaction
xref: KEGG:R01360 "KEGG reaction"
xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24407 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00164 ! acetoacetate
relationship: has_output_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate
relationship: part_of UPa:UER00863 ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1
relationship: part_of UPa:UER00863 {cardinality="1", direction="LR", order="1"} ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1

[Term]
id: UPa:UCR01364
name: acetoacetate + fumarate = 4-fumarylacetoacetate + H(2)O
namespace: reaction
xref: KEGG:R01364 "KEGG reaction"
xref: METACYC:FUMARYLACETOACETASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10247 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00122 ! fumarate
relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: has_input_compound UPa:UPC00164 ! acetoacetate
relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01061 ! 4-fumarylacetoacetate
relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate
relationship: part_of UPa:UER00341 ! acetoacetate and fumarate from L-phenylalanine: step 6/6
relationship: part_of UPa:UER00341 {cardinality="1", direction="RL", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 6/6

[Term]
id: UPa:UCR01373
name: prephenate = CO(2) + H(2)O + phenylpyruvate
namespace: reaction
xref: KEGG:R01373 "KEGG reaction"
xref: METACYC:PREPHENATEDEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21651 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00254 ! prephenate
relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00166 ! phenylpyruvate
relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate
relationship: part_of UPa:UER00345 {cardinality="1", direction="LR", order="1"} ! phenylpyruvate from prephenate: step 1/1
relationship: part_of UPa:UER00345 ! phenylpyruvate from prephenate: step 1/1

[Term]
id: UPa:UCR01384
name: UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose
namespace: reaction
xref: KEGG:R01384 "KEGG reaction"
xref: METACYC:UDP-GLUCURONATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23919 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00167 ! UDP-alpha-D-glucuronate
relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose
relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose
relationship: part_of UPa:UER00771 ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1
relationship: part_of UPa:UER00771 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1

[Term]
id: UPa:UCR01388
name: D-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH
namespace: reaction
xref: KEGG:R01388 "KEGG reaction"
xref: METACYC:GLYCERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17908 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate
relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate
relationship: part_of UPa:UER00916 {cardinality="1", direction="RL", order="1"} ! 3-phospho-D-glycerate from glycine: step 3/4
relationship: part_of UPa:UER00916 ! 3-phospho-D-glycerate from glycine: step 3/4
relationship: part_of UPa:UER00983 ! None
relationship: part_of UPa:UER00983 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01392
name: D-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01392 "KEGG reaction"
xref: METACYC:RXN0-300 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:18660 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate
relationship: has_output_compound UPa:UPC00168 ! 3-hydroxypyruvate
relationship: part_of UPa:UER00984 ! None
relationship: part_of UPa:UER00984 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01397
name: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + phosphate
namespace: reaction
xref: KEGG:R01397 "KEGG reaction"
xref: METACYC:ASPCARBTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20016 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate
relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate
relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate
relationship: part_of UPa:UER00116 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 2/3
relationship: part_of UPa:UER00116 ! (S)-dihydroorotate from bicarbonate: step 2/3

[Term]
id: UPa:UCR01398
name: L-ornithine + carbamoyl phosphate = L-citrulline + phosphate
namespace: reaction
xref: KEGG:R01398 "KEGG reaction"
xref: METACYC:ORNCARBAMTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19516 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00077 ! L-ornithine
relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate
relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline
relationship: has_output_compound UPa:UPC00327 ! L-citrulline
relationship: part_of UPa:UER00112 ! L-arginine from L-ornithine and carbamoyl phosphate: step 1/3
relationship: part_of UPa:UER00112 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 1/3
relationship: part_of UPa:UER00271 ! L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1
relationship: part_of UPa:UER00271 {cardinality="1", direction="LR", order="1"} ! L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1
relationship: part_of UPa:UER00365 ! carbamoyl phosphate from L-arginine: step 2/2
relationship: part_of UPa:UER00365 {cardinality="1", direction="RL", order="1"} ! carbamoyl phosphate from L-arginine: step 2/2

[Term]
id: UPa:UCR01399
name: carbamoyl phosphate + putrescine = N-carbamoylputrescine + phosphate
namespace: reaction
xref: KEGG:R01399 "KEGG reaction"
xref: METACYC:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21939 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate
relationship: has_input_compound UPa:UPC00169 ! carbamoyl phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine
relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine
relationship: part_of UPa:UER00941 ! putrescine from N-carbamoylputrescine (transferase route): step 1/1
relationship: part_of UPa:UER00941 {cardinality="1", direction="RL", order="1"} ! putrescine from N-carbamoylputrescine (transferase route): step 1/1

[Term]
id: UPa:UCR01401
name: H(2)O + S-methyl-5'-thioadenosine = 5-methylthio-alpha-D-ribose + adenine
namespace: reaction
xref: KEGG:R01401 "KEGG reaction"
xref: METACYC:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13620 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine
relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine
relationship: has_output_compound UPa:UPC00147 ! adenine
relationship: has_output_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose
relationship: has_output_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose
relationship: part_of UPa:UER00871 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2
relationship: part_of UPa:UER00871 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2

[Term]
id: UPa:UCR01402
name: S-methyl-5'-thioadenosine + phosphate = S-methyl-5-thio-alpha-D-ribose 1-phosphate + adenine
namespace: reaction
xref: KEGG:R01402 "KEGG reaction"
xref: METACYC:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11855 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine
relationship: has_input_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine
relationship: has_output_compound UPa:UPC00147 ! adenine
relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: part_of UPa:UER00873 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1
relationship: part_of UPa:UER00873 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1

[Term]
id: UPa:UCR01416
name: H(2)O + agmatine = N-carbamoylputrescine + NH(3)
namespace: reaction
xref: KEGG:R01416 "KEGG reaction"
xref: METACYC:AGMATINE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18040 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00179 ! agmatine
relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine
relationship: has_output_compound UPa:UPC00436 ! N-carbamoylputrescine
relationship: part_of UPa:UER00285 {cardinality="1", direction="LR", order="1"} ! N-carbamoylputrescine from agmatine: step 1/1
relationship: part_of UPa:UER00285 ! N-carbamoylputrescine from agmatine: step 1/1

[Term]
id: UPa:UCR01419
name: H(2)O + NAD(+) + benzaldehyde = H(+) + NADH + benzoate
namespace: reaction
xref: KEGG:R01419 "KEGG reaction"
xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11843 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde
relationship: has_input_compound UPa:UPC00261 ! benzaldehyde
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate
relationship: has_output_compound UPa:UPC00180 ! benzoate
relationship: part_of UPa:UER00988 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00988 ! None

[Term]
id: UPa:UCR01420
name: H(2)O + NADP(+) + benzaldehyde = H(+) + NADPH + benzoate
namespace: reaction
xref: KEGG:R01420 "KEGG reaction"
xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21663 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00261 ! benzaldehyde
relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate
relationship: has_output_compound UPa:UPC00180 ! benzoate
relationship: part_of UPa:UER00987 ! None
relationship: part_of UPa:UER00987 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01465
name: L-threonine + NAD(+) = H(+) + L-2-amino-3-oxobutanoic acid + NADH
namespace: reaction
xref: KEGG:R01465 "KEGG reaction"
xref: METACYC:THREODEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13164 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine
relationship: has_input_compound UPa:UPC00188 ! L-threonine
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid
relationship: has_output_compound UPa:UPC03508 ! L-2-amino-3-oxobutanoic acid
relationship: part_of UPa:UER00505 {cardinality="1", direction="LR", order="1"} ! glycine from L-threonine: step 1/2
relationship: part_of UPa:UER00505 ! glycine from L-threonine: step 1/2

[Term]
id: UPa:UCR01466
name: H(2)O + O-phospho-L-homoserine = L-threonine + phosphate
namespace: reaction
xref: KEGG:R01466 "KEGG reaction"
xref: METACYC:THRESYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10843 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01102 ! O-phospho-L-homoserine
relationship: has_input_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00188 {cardinality="1"} ! L-threonine
relationship: has_output_compound UPa:UPC00188 ! L-threonine
relationship: part_of UPa:UER00065 ! L-threonine from L-aspartate: step 5/5
relationship: part_of UPa:UER00065 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 5/5

[Term]
id: UPa:UCR01468
name: ATP + ethanolamine = ADP + phosphoethanolamine
namespace: reaction
xref: KEGG:R01468 "KEGG reaction"
xref: METACYC:ETHANOLAMINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13072 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00189 ! ethanolamine
relationship: has_input_compound UPa:UPC00189 {cardinality="1"} ! ethanolamine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine
relationship: has_output_compound UPa:UPC00346 ! phosphoethanolamine
relationship: part_of UPa:UER00741 ! phosphatidylethanolamine from ethanolamine: step 1/3
relationship: part_of UPa:UER00741 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 1/3

[Term]
id: UPa:UCR01473
name: UDP-L-arabinose = UDP-alpha-D-xylose
namespace: reaction
xref: KEGG:R01473 "KEGG reaction"
xref: METACYC:UDP-ARABINOSE-4-EPIMERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11323 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00935 ! UDP-L-arabinose
relationship: has_input_compound UPa:UPC00935 {cardinality="1"} ! UDP-L-arabinose
relationship: has_output_compound UPa:UPC00190 ! UDP-alpha-D-xylose
relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose
relationship: part_of UPa:UER00772 {cardinality="1", direction="RL", order="1"} ! UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1
relationship: part_of UPa:UER00772 ! UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1

[Term]
id: UPa:UCR01481
name: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01481 "KEGG reaction"
xref: METACYC:GLUCURONATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14912 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00800 ! L-gulonate
relationship: has_input_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate
relationship: has_output_compound UPa:UPC00191 ! D-glucuronate
relationship: part_of UPa:UER00937 ! L-ascorbate from UDP-alpha-D-glucuronate: step 2/4
relationship: part_of UPa:UER00937 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 2/4

[Term]
id: UPa:UCR01512
name: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP
namespace: reaction
xref: KEGG:R01512 "KEGG reaction"
xref: METACYC:PHOSGLYPHOS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14804 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate
relationship: has_output_compound UPa:UPC00236 ! 3-phospho-D-glyceroyl phosphate
relationship: part_of UPa:UER00185 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 2/5
relationship: part_of UPa:UER00185 ! pyruvate from D-glyceraldehyde 3-phosphate: step 2/5

[Term]
id: UPa:UCR01513
name: 3-phospho-D-glycerate + NAD(+) = 3-phosphohydroxypyruvate + H(+) + NADH
namespace: reaction
xref: KEGG:R01513 "KEGG reaction"
xref: METACYC:PGLYCDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12644 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate
relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate
relationship: part_of UPa:UER00196 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 1/3
relationship: part_of UPa:UER00196 ! L-serine from 3-phospho-D-glycerate: step 1/3

[Term]
id: UPa:UCR01514
name: ATP + D-glycerate = 3-phospho-D-glycerate + ADP
namespace: reaction
xref: KEGG:R01514 "KEGG reaction"
xref: METACYC:GLY3KIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23519 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate
relationship: part_of UPa:UER00833 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 4/4
relationship: part_of UPa:UER00833 ! 3-phospho-D-glycerate from glycolate: step 4/4
relationship: part_of UPa:UER00917 ! 3-phospho-D-glycerate from glycine: step 4/4
relationship: part_of UPa:UER00917 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 4/4

[Term]
id: UPa:UCR01518
name: 2-phospho-D-glycerate = 3-phospho-D-glycerate
namespace: reaction
xref: KEGG:R01518 "KEGG reaction"
xref: METACYC:3PGAREARR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15904 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00197 ! 3-phospho-D-glycerate
relationship: part_of UPa:UER00186 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 3/5
relationship: part_of UPa:UER00186 ! pyruvate from D-glyceraldehyde 3-phosphate: step 3/5

[Term]
id: UPa:UCR01519
name: D-glucono-1,5-lactone + H(2)O = D-gluconate
namespace: reaction
xref: KEGG:R01519 "KEGG reaction"
xref: METACYC:GLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10443 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00198 ! D-glucono-1,5-lactone
relationship: has_input_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone
relationship: has_output_compound UPa:UPC00257 {cardinality="1"} ! D-gluconate
relationship: has_output_compound UPa:UPC00257 ! D-gluconate
relationship: part_of UPa:UER00785 ! D-gluconate from D-glucono-1,5-lactone: step 1/1
relationship: part_of UPa:UER00785 {cardinality="1", direction="LR", order="1"} ! D-gluconate from D-glucono-1,5-lactone: step 1/1

[Term]
id: UPa:UCR01528
name: 6-phospho-D-gluconate + NADP(+) = CO(2) + D-ribulose 5-phosphate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01528 "KEGG reaction"
xref: METACYC:RXN-9952 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10119 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate
relationship: has_input_compound UPa:UPC00345 ! 6-phospho-D-gluconate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: part_of UPa:UER00410 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3
relationship: part_of UPa:UER00410 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3

[Term]
id: UPa:UCR01529
name: D-ribulose 5-phosphate = D-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R01529 "KEGG reaction"
xref: METACYC:RIBULP3EPIM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13680 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate
relationship: part_of UPa:UER00411 ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1
relationship: part_of UPa:UER00411 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1

[Term]
id: UPa:UCR01530
name: D-arabinose 5-phosphate = D-ribulose 5-phosphate
namespace: reaction
xref: KEGG:R01530 "KEGG reaction"
xref: METACYC:DARAB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23107 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate
relationship: has_input_compound UPa:UPC01112 ! D-arabinose 5-phosphate
relationship: has_output_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: part_of UPa:UER00473 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3
relationship: part_of UPa:UER00473 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3

[Term]
id: UPa:UCR01541
name: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconic acid + ADP
namespace: reaction
xref: KEGG:R01541 "KEGG reaction"
xref: METACYC:DEOXYGLUCONOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14800 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate
relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid
relationship: has_output_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid
relationship: part_of UPa:UER00828 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2
relationship: part_of UPa:UER00828 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2

[Term]
id: UPa:UCR01542
name: 2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-hexo-2,5-diulosonate + H(+) + NADH
namespace: reaction
xref: KEGG:R01542 "KEGG reaction"
xref: METACYC:1.1.1.127-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24235 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00204 ! 2-dehydro-3-deoxy-D-gluconate
relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate
relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate
relationship: part_of UPa:UER00827 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5
relationship: part_of UPa:UER00827 {cardinality="1", direction="RL", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5

[Term]
id: UPa:UCR01563
name: H(2)O + N-carbamoylsarcosine = CO(2) + NH(3) + sarcosine
namespace: reaction
xref: KEGG:R01563 "KEGG reaction"
xref: METACYC:N-CARBAMOYLSARCOSINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20060 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine
relationship: has_input_compound UPa:UPC01043 ! N-carbamoylsarcosine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00213 ! sarcosine
relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine
relationship: part_of UPa:UER00397 ! sarcosine from creatinine: step 3/3
relationship: part_of UPa:UER00397 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 3/3

[Term]
id: UPa:UCR01565
name: H(2)O + N,N-dimethylglycine + electron-transferring flavoprotein = formaldehyde + reduced electron-transferring flavoprotein + sarcosine
namespace: reaction
xref: KEGG:R01565 "KEGG reaction"
xref: METACYC:DIMETHYLGLYCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22499 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine
relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine
relationship: has_input_compound UPa:UPC04253 ! electron-transferring flavoprotein
relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein
relationship: has_output_compound UPa:UPC00067 ! formaldehyde
relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_output_compound UPa:UPC00213 ! sarcosine
relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine
relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein
relationship: has_output_compound UPa:UPC04570 ! reduced electron-transferring flavoprotein
relationship: part_of UPa:UER00433 ! sarcosine from betaine: step 2/2
relationship: part_of UPa:UER00433 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 2/2

[Term]
id: UPa:UCR01567
name: ATP + thymidine = ADP + dTMP
namespace: reaction
xref: KEGG:R01567 "KEGG reaction"
xref: METACYC:THYKI-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19132 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00214 ! thymidine
relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00364 {cardinality="1"} ! dTMP
relationship: has_output_compound UPa:UPC00364 ! dTMP
relationship: part_of UPa:UER00639 {cardinality="1", direction="LR", order="1"} ! dTMP from thymine: step 2/2
relationship: part_of UPa:UER00639 ! dTMP from thymine: step 2/2

[Term]
id: UPa:UCR01570
name: phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
namespace: reaction
xref: KEGG:R01570 "KEGG reaction"
xref: METACYC:THYM-PHOSPH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16040 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00214 ! thymidine
relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine
relationship: has_output_compound UPa:UPC00178 ! thymine
relationship: has_output_compound UPa:UPC00178 {cardinality="1"} ! thymine
relationship: has_output_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate
relationship: part_of UPa:UER00638 ! dTMP from thymine: step 1/2
relationship: part_of UPa:UER00638 {cardinality="1", direction="RL", order="1"} ! dTMP from thymine: step 1/2

[Term]
id: UPa:UCR01574
name: D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH
namespace: reaction
xref: KEGG:R01574 "KEGG reaction"
xref: METACYC:D-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20460 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00216 ! D-arabinose
relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone
relationship: part_of UPa:UER00977 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00977 ! None

[Term]
id: UPa:UCR01575
name: D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH
namespace: reaction
xref: KEGG:R01575 "KEGG reaction"
xref: METACYC:RXN-8776 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21895 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00216 ! D-arabinose
relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC00652 ! D-arabinono-1,4-lactone
relationship: part_of UPa:UER00978 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00978 ! None

[Term]
id: UPa:UCR01614
name: 4-coumaroyl-CoA + 3 malonyl-CoA = 3,4',5-trihydroxystilbene + 4 CO(2) + 4 CoA
namespace: reaction
xref: KEGG:R01614 "KEGG reaction"
xref: METACYC:RXN-87 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11939 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00083 ! malonyl-CoA
relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA
relationship: has_input_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA
relationship: has_input_compound UPa:UPC00223 ! 4-coumaroyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC03582 {cardinality="1"} ! 3,4',5-trihydroxystilbene
relationship: has_output_compound UPa:UPC03582 ! 3,4',5-trihydroxystilbene
relationship: part_of UPa:UER00548 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2
relationship: part_of UPa:UER00548 ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2

[Term]
id: UPa:UCR01616
name: ATP + CoA + trans-4-coumarate = 4-coumaroyl-CoA + AMP + diphosphate
namespace: reaction
xref: KEGG:R01616 "KEGG reaction"
xref: METACYC:4-COUMARATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19644 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate
relationship: has_input_compound UPa:UPC00811 ! trans-4-coumarate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA
relationship: has_output_compound UPa:UPC00223 ! 4-coumaroyl-CoA
relationship: part_of UPa:UER00547 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2
relationship: part_of UPa:UER00547 ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2

[Term]
id: UPa:UCR01620
name: L-lysine + acetyl phosphate = N(6)-acetyl-L-lysine + phosphate
namespace: reaction
xref: KEGG:R01620 "KEGG reaction"
xref: METACYC:LYSINE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14420 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00047 ! L-lysine
relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine
relationship: has_input_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate
relationship: has_input_compound UPa:UPC00227 ! acetyl phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine
relationship: has_output_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine
relationship: part_of UPa:UER00841 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 1/6
relationship: part_of UPa:UER00841 ! glutarate from L-lysine: step 1/6

[Term]
id: UPa:UCR01627
name: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H(2)O
namespace: reaction
xref: KEGG:R01627 "KEGG reaction"
xref: METACYC:DHSHIKIMATE-DEHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24851 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02637 ! 3-dehydroshikimate
relationship: has_input_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: part_of UPa:UER00179 ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2
relationship: part_of UPa:UER00179 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2

[Term]
id: UPa:UCR01629
name: 3,4-dihydroxybenzoate + H(+) + NADH + O(2) = CO(2) + H(2)O + NAD(+) + benzene-1,2,4-triol
namespace: reaction
xref: KEGG:R01629 "KEGG reaction"
xref: RHEA:30038 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol
relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol
relationship: part_of UPa:UER00955 ! None
relationship: part_of UPa:UER00955 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01630
name: 3,4-dihydroxybenzoate + H(+) + NADPH + O(2) = CO(2) + H(2)O + NADP(+) + benzene-1,2,4-triol
namespace: reaction
xref: KEGG:R01630 "KEGG reaction"
xref: RHEA:30042 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol
relationship: has_output_compound UPa:UPC02814 ! benzene-1,2,4-triol
relationship: part_of UPa:UER00956 ! None
relationship: part_of UPa:UER00956 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01631
name: 3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate
namespace: reaction
xref: KEGG:R01631 "KEGG reaction"
xref: METACYC:PROTOCATECHUATE-34-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10087 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: has_input_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate
relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate
relationship: part_of UPa:UER00264 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1
relationship: part_of UPa:UER00264 ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1

[Term]
id: UPa:UCR01635
name: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO(2)
namespace: reaction
xref: KEGG:R01635 "KEGG reaction"
xref: METACYC:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24187 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate
relationship: has_input_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate
relationship: has_output_compound UPa:UPC00230 ! 3,4-dihydroxybenzoate
relationship: part_of UPa:UER00730 ! 3,4-dihydroxybenzoate from phthalate: step 3/3
relationship: part_of UPa:UER00730 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 3/3

[Term]
id: UPa:UCR01639
name: ATP + D-xylulose = ADP + D-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R01639 "KEGG reaction"
xref: METACYC:XYLULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10967 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose
relationship: has_input_compound UPa:UPC00310 ! D-xylulose
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate
relationship: part_of UPa:UER00578 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5
relationship: part_of UPa:UER00578 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5

[Term]
id: UPa:UCR01641
name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R01641 "KEGG reaction"
xref: METACYC:1TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10511 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate
relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate
relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00117 ! D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate
relationship: part_of UPa:UER00413 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3
relationship: part_of UPa:UER00413 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3

[Term]
id: UPa:UCR01647
name: pyruvate + succinate semialdehyde = 2,4-dihydroxyhept-2-enedioic acid
namespace: reaction
xref: KEGG:R01647 "KEGG reaction"
xref: RHEA:25791 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde
relationship: has_input_compound UPa:UPC00232 ! succinate semialdehyde
relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid
relationship: has_output_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid
relationship: part_of UPa:UER00422 {cardinality="1", direction="RL", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7
relationship: part_of UPa:UER00422 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7

[Term]
id: UPa:UCR01648
name: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde
namespace: reaction
xref: KEGG:R01648 "KEGG reaction"
xref: METACYC:GABATRANSAM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23355 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate
relationship: has_input_compound UPa:UPC00334 ! 4-aminobutanoate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00232 ! succinate semialdehyde
relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde
relationship: part_of UPa:UER00293 {cardinality="1", direction="LR", order="1"} ! succinate semialdehyde from 4-aminobutanoate: step 1/1
relationship: part_of UPa:UER00293 ! succinate semialdehyde from 4-aminobutanoate: step 1/1

[Term]
id: UPa:UCR01651
name: 4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-isovaleryl-CoA + CO(2) + H(+) + NADH
namespace: reaction
xref: KEGG:R01651 "KEGG reaction"
xref: METACYC:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25180 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate
relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC02939 ! 3-isovaleryl-CoA
relationship: has_output_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA
relationship: part_of UPa:UER00859 {cardinality="1", direction="LR", order="1"} ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1
relationship: part_of UPa:UER00859 ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1

[Term]
id: UPa:UCR01652
name: 4-methyl-2-oxopentanoate + CO(2) = 3-carboxy-4-methyl-2-oxopentanoate
namespace: reaction
xref: KEGG:R01652 "KEGG reaction"
xref: METACYC:RXN-7800 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25081 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate
relationship: has_input_compound UPa:UPC00233 ! 4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC04236 ! 3-carboxy-4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate
relationship: part_of UPa:UER00072 ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4
relationship: part_of UPa:UER00072 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4

[Term]
id: UPa:UCR01658
name: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
namespace: reaction
xref: KEGG:R01658 "KEGG reaction"
xref: METACYC:GPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22411 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate
relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: part_of UPa:UER00368 {cardinality="1", direction="LR", order="1"} ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1
relationship: part_of UPa:UER00368 ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1

[Term]
id: UPa:UCR01676
name: H(2)O + guanine = NH(3) + xanthine
namespace: reaction
xref: KEGG:R01676 "KEGG reaction"
xref: METACYC:GUANINE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14668 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00242 ! guanine
relationship: has_input_compound UPa:UPC00242 {cardinality="1"} ! guanine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00385 ! xanthine
relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine
relationship: part_of UPa:UER00660 ! xanthine from guanine: step 1/1
relationship: part_of UPa:UER00660 {cardinality="1", direction="LR", order="1"} ! xanthine from guanine: step 1/1

[Term]
id: UPa:UCR01681
name: H(2)O + NAD(+) + hypotaurine = H(+) + NADH + taurine
namespace: reaction
xref: KEGG:R01681 "KEGG reaction"
xref: METACYC:HYPOTAURINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17388 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00519 ! hypotaurine
relationship: has_input_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00245 ! taurine
relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine
relationship: part_of UPa:UER00539 ! taurine from hypotaurine: step 1/1
relationship: part_of UPa:UER00539 {cardinality="1", direction="LR", order="1"} ! taurine from hypotaurine: step 1/1

[Term]
id: UPa:UCR01682
name: L-cysteate = CO(2) + taurine
namespace: reaction
xref: KEGG:R01682 "KEGG reaction"
xref: METACYC:CYSTAUR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25224 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00506 ! L-cysteate
relationship: has_input_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00245 ! taurine
relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine
relationship: part_of UPa:UER00541 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 2/2
relationship: part_of UPa:UER00541 ! taurine from L-cysteine: step 2/2

[Term]
id: UPa:UCR01707
name: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH
namespace: reaction
xref: KEGG:R01707 "KEGG reaction"
xref: METACYC:PYRIDOXAL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21339 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00250 ! pyridoxal
relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone
relationship: has_output_compound UPa:UPC00971 ! 4-pyridoxolactone
relationship: part_of UPa:UER00588 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 1/2
relationship: part_of UPa:UER00588 ! 4-pyridoxate from pyridoxal: step 1/2

[Term]
id: UPa:UCR01708
name: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal
namespace: reaction
xref: KEGG:R01708 "KEGG reaction"
xref: METACYC:PYRIDOXINE-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16132 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00314 ! pyridoxine
relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: has_output_compound UPa:UPC00250 ! pyridoxal
relationship: part_of UPa:UER00307 ! pyridoxal from pyridoxine (dehydrogenase route): step 1/1
relationship: part_of UPa:UER00307 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (dehydrogenase route): step 1/1

[Term]
id: UPa:UCR01711
name: O(2) + pyridoxine = H(2)O(2) + pyridoxal
namespace: reaction
xref: KEGG:R01711 "KEGG reaction"
xref: METACYC:PYRIDOXINE-4-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15036 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00314 ! pyridoxine
relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00250 ! pyridoxal
relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: part_of UPa:UER00590 ! pyridoxal from pyridoxine (oxidase route): step 1/1
relationship: part_of UPa:UER00590 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (oxidase route): step 1/1

[Term]
id: UPa:UCR01712
name: pyridoxamine + pyruvate = L-alanine + pyridoxal
namespace: reaction
xref: KEGG:R01712 "KEGG reaction"
xref: METACYC:2.6.1.30-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12844 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00534 ! pyridoxamine
relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine
relationship: has_output_compound UPa:UPC00041 ! L-alanine
relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00250 ! pyridoxal
relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal
relationship: part_of UPa:UER00306 ! pyridoxal from pyridoxamine: step 1/1
relationship: part_of UPa:UER00306 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxamine: step 1/1

[Term]
id: UPa:UCR01714
name: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
namespace: reaction
xref: KEGG:R01714 "KEGG reaction"
xref: METACYC:CHORISMATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21023 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate
relationship: has_input_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00251 ! chorismate
relationship: has_output_compound UPa:UPC00251 {cardinality="1"} ! chorismate
relationship: part_of UPa:UER00090 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7
relationship: part_of UPa:UER00090 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7

[Term]
id: UPa:UCR01715
name: chorismate = prephenate
namespace: reaction
xref: KEGG:R01715 "KEGG reaction"
xref: METACYC:CHORISMATEMUT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13900 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00251 ! chorismate
relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate
relationship: has_output_compound UPa:UPC00254 ! prephenate
relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: part_of UPa:UER00203 ! prephenate from chorismate: step 1/1
relationship: part_of UPa:UER00203 {cardinality="1", direction="LR", order="1"} ! prephenate from chorismate: step 1/1

[Term]
id: UPa:UCR01717
name: chorismate = isochorismate
namespace: reaction
xref: KEGG:R01717 "KEGG reaction"
xref: METACYC:ISOCHORSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18988 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00251 ! chorismate
relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate
relationship: has_output_compound UPa:UPC00885 {cardinality="1"} ! isochorismate
relationship: has_output_compound UPa:UPC00885 ! isochorismate
relationship: part_of UPa:UER00163 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7
relationship: part_of UPa:UER00163 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7

[Term]
id: UPa:UCR01720
name: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01720 "KEGG reaction"
xref: METACYC:RXN-7637 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12239 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00253 ! nicotinate
relationship: has_input_compound UPa:UPC00253 {cardinality="1"} ! nicotinate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate
relationship: has_output_compound UPa:UPC01020 ! 6-hydroxynicotinate
relationship: part_of UPa:UER01011 {cardinality="1", direction="LR", order="1"} ! 6-hydroxynicotinate from nicotinate: step 1/1
relationship: part_of UPa:UER01011 ! 6-hydroxynicotinate from nicotinate: step 1/1

[Term]
id: UPa:UCR01724
name: ADP + diphosphate + nicotinate D-ribonucleotide + phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(+) + H(2)O + nicotinate
namespace: reaction
xref: KEGG:R01724 "KEGG reaction"
xref: METACYC:NICOTINATEPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13396 "Rhea reaction"
xref: RHEA:36166 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00008 ! ADP
relationship: has_input_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide
relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_output_compound UPa:UPC00002 ! ATP
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate
relationship: has_output_compound UPa:UPC00253 ! nicotinate
relationship: part_of UPa:UER00457 ! nicotinate D-ribonucleotide from nicotinate: step 1/1
relationship: part_of UPa:UER00457 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from nicotinate: step 1/1

[Term]
id: UPa:UCR01728
name: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADH
namespace: reaction
xref: KEGG:R01728 "KEGG reaction"
xref: METACYC:PREPHENATEDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13872 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00254 ! prephenate
relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate
relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate
relationship: part_of UPa:UER00961 ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1
relationship: part_of UPa:UER00961 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1

[Term]
id: UPa:UCR01730
name: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADPH
namespace: reaction
xref: KEGG:R01730 "KEGG reaction"
xref: METACYC:PREPHENATE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21643 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: has_input_compound UPa:UPC00254 ! prephenate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate
relationship: has_output_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate
relationship: part_of UPa:UER00962 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1
relationship: part_of UPa:UER00962 ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1

[Term]
id: UPa:UCR01731
name: L-arogenate + oxaloacetate = L-aspartate + prephenate
namespace: reaction
xref: KEGG:R01731 "KEGG reaction"
xref: METACYC:PREPHENATE-ASP-TRANSAMINE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20448 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate
relationship: has_input_compound UPa:UPC00036 ! oxaloacetate
relationship: has_input_compound UPa:UPC00826 ! L-arogenate
relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate
relationship: has_output_compound UPa:UPC00049 ! L-aspartate
relationship: has_output_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: has_output_compound UPa:UPC00254 ! prephenate
relationship: part_of UPa:UER00342 ! L-arogenate from prephenate (L-Asp route): step 1/1
relationship: part_of UPa:UER00342 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Asp route): step 1/1

[Term]
id: UPa:UCR01736
name: (R)-S-lactoylglutathione + H(2)O = (R)-lactate + glutathione
namespace: reaction
xref: KEGG:R01736 "KEGG reaction"
xref: METACYC:GLYOXII-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25248 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione
relationship: has_input_compound UPa:UPC03451 ! (R)-S-lactoylglutathione
relationship: has_output_compound UPa:UPC00051 ! glutathione
relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione
relationship: has_output_compound UPa:UPC00256 ! (R)-lactate
relationship: has_output_compound UPa:UPC00256 {cardinality="1"} ! (R)-lactate
relationship: part_of UPa:UER00676 {cardinality="1", direction="LR", order="1"} ! (R)-lactate from methylglyoxal: step 2/2
relationship: part_of UPa:UER00676 ! (R)-lactate from methylglyoxal: step 2/2

[Term]
id: UPa:UCR01745
name: D-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH
namespace: reaction
xref: KEGG:R01745 "KEGG reaction"
xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18848 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate
relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate
relationship: part_of UPa:UER00973 ! None
relationship: part_of UPa:UER00973 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR01747
name: D-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01747 "KEGG reaction"
xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: METACYC:TSA-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18844 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate
relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate
relationship: part_of UPa:UER00974 ! None
relationship: part_of UPa:UER00974 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR01749
name: CO(2) + D-glycerate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH
namespace: reaction
xref: KEGG:R01749 "KEGG reaction"
xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:13156 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate
relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate
relationship: part_of UPa:UER00981 {cardinality="1", direction="RL", order="1"} ! None
relationship: part_of UPa:UER00981 ! None

[Term]
id: UPa:UCR01750
name: CO(2) + D-glycerate + NADP(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADPH
namespace: reaction
xref: KEGG:R01750 "KEGG reaction"
xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13160 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_input_compound UPa:UPC00258 ! D-glycerate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate
relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate
relationship: part_of UPa:UER00982 {cardinality="1", direction="RL", order="1"} ! None
relationship: part_of UPa:UER00982 ! None

[Term]
id: UPa:UCR01751
name: L-tartrate = CO(2) + D-glycerate
namespace: reaction
xref: KEGG:R01751 "KEGG reaction"
xref: METACYC:TARTRATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13320 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00898 ! L-tartrate
relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate
relationship: has_output_compound UPa:UPC00258 ! D-glycerate
relationship: part_of UPa:UER00803 {cardinality="1", direction="LR", order="1"} ! D-glycerate from L-tartrate: step 1/1
relationship: part_of UPa:UER00803 ! D-glycerate from L-tartrate: step 1/1

[Term]
id: UPa:UCR01757
name: L-arabinose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH
namespace: reaction
xref: KEGG:R01757 "KEGG reaction"
xref: METACYC:L-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17928 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose
relationship: has_input_compound UPa:UPC00259 ! L-arabinose
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01114 ! L-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone
relationship: part_of UPa:UER00568 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3
relationship: part_of UPa:UER00568 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3

[Term]
id: UPa:UCR01758
name: L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH
namespace: reaction
xref: KEGG:R01758 "KEGG reaction"
xref: METACYC:RXN-14102 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:25228 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol
relationship: has_input_compound UPa:UPC00532 ! L-arabinitol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose
relationship: has_output_compound UPa:UPC00259 ! L-arabinose
relationship: part_of UPa:UER00969 ! None
relationship: part_of UPa:UER00969 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR01759
name: L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH
namespace: reaction
xref: KEGG:R01759 "KEGG reaction"
xref: METACYC:RXN-8772 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25232 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol
relationship: has_input_compound UPa:UPC00532 ! L-arabinitol
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00259 ! L-arabinose
relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose
relationship: part_of UPa:UER00970 ! None
relationship: part_of UPa:UER00970 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR01761
name: L-arabinose = L-ribulose
namespace: reaction
xref: KEGG:R01761 "KEGG reaction"
xref: METACYC:ARABISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14824 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose
relationship: has_input_compound UPa:UPC00259 ! L-arabinose
relationship: has_output_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose
relationship: has_output_compound UPa:UPC00508 ! L-ribulose
relationship: part_of UPa:UER00565 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3
relationship: part_of UPa:UER00565 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3

[Term]
id: UPa:UCR01764
name: phenylglyoxylate = CO(2) + benzaldehyde
namespace: reaction
xref: KEGG:R01764 "KEGG reaction"
xref: METACYC:BENZOYLFORMATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23371 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02137 ! phenylglyoxylate
relationship: has_input_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00261 ! benzaldehyde
relationship: has_output_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde
relationship: part_of UPa:UER00854 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 3/4
relationship: part_of UPa:UER00854 ! benzoate from (R)-mandelate: step 3/4

[Term]
id: UPa:UCR01768
name: H(2)O + NAD(+) + hypoxanthine = H(+) + NADH + xanthine
namespace: reaction
xref: KEGG:R01768 "KEGG reaction"
xref: METACYC:RXN-7682 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24673 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00262 ! hypoxanthine
relationship: has_input_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine
relationship: has_output_compound UPa:UPC00385 ! xanthine
relationship: part_of UPa:UER00661 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 1/2
relationship: part_of UPa:UER00661 ! urate from hypoxanthine: step 1/2

[Term]
id: UPa:UCR01771
name: ATP + L-homoserine = ADP + O-phospho-L-homoserine
namespace: reaction
xref: KEGG:R01771 "KEGG reaction"
xref: METACYC:HOMOSERKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13988 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine
relationship: has_input_compound UPa:UPC00263 ! L-homoserine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01102 ! O-phospho-L-homoserine
relationship: has_output_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine
relationship: part_of UPa:UER00064 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 4/5
relationship: part_of UPa:UER00064 ! L-threonine from L-aspartate: step 4/5

[Term]
id: UPa:UCR01773
name: L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH
namespace: reaction
xref: KEGG:R01773 "KEGG reaction"
xref: RHEA:15760 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine
relationship: has_input_compound UPa:UPC00263 ! L-homoserine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde
relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde
relationship: part_of UPa:UER00949 ! None
relationship: part_of UPa:UER00949 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR01775
name: L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH
namespace: reaction
xref: KEGG:R01775 "KEGG reaction"
xref: METACYC:HOMOSERDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15764 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine
relationship: has_input_compound UPa:UPC00263 ! L-homoserine
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde
relationship: has_output_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde
relationship: part_of UPa:UER00950 {cardinality="1", direction="RL", order="1"} ! None
relationship: part_of UPa:UER00950 ! None

[Term]
id: UPa:UCR01776
name: L-homoserine + acetyl-CoA = CoA + O-acetyl-L-homoserine
namespace: reaction
xref: KEGG:R01776 "KEGG reaction"
xref: METACYC:HOMOSERINE-O-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13704 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine
relationship: has_input_compound UPa:UPC00263 ! L-homoserine
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC01077 ! O-acetyl-L-homoserine
relationship: has_output_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine
relationship: part_of UPa:UER00074 ! O-acetyl-L-homoserine from L-homoserine: step 1/1
relationship: part_of UPa:UER00074 {cardinality="1", direction="LR", order="1"} ! O-acetyl-L-homoserine from L-homoserine: step 1/1

[Term]
id: UPa:UCR01777
name: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
namespace: reaction
xref: KEGG:R01777 "KEGG reaction"
xref: METACYC:HOMSUCTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22011 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine
relationship: has_input_compound UPa:UPC00263 ! L-homoserine
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine
relationship: has_output_compound UPa:UPC01118 ! O-succinyl-L-homoserine
relationship: part_of UPa:UER00075 {cardinality="1", direction="LR", order="1"} ! O-succinyl-L-homoserine from L-homoserine: step 1/1
relationship: part_of UPa:UER00075 ! O-succinyl-L-homoserine from L-homoserine: step 1/1

[Term]
id: UPa:UCR01784
name: 2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate
namespace: reaction
xref: KEGG:R01784 "KEGG reaction"
xref: METACYC:4.1.2.18-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18548 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate
relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde
relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde
relationship: part_of UPa:UER00571 ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1
relationship: part_of UPa:UER00571 {cardinality="1", direction="LR", order="1"} ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1

[Term]
id: UPa:UCR01793
name: H(+) + NADH + dihydrobiopterin = NAD(+) + tetrahydrobiopterin
namespace: reaction
xref: KEGG:R01793 "KEGG reaction"
xref: METACYC:1.5.1.34-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: METACYC:RXN-7909 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17872 "Rhea reaction"
xref: RHEA:32254 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin
relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: part_of UPa:UER00993 ! None
relationship: part_of UPa:UER00993 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01794
name: H(+) + NADPH + dihydrobiopterin = NADP(+) + tetrahydrobiopterin
namespace: reaction
xref: KEGG:R01794 "KEGG reaction"
xref: RHEA:32250 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00268 ! dihydrobiopterin
relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: part_of UPa:UER00994 ! None
relationship: part_of UPa:UER00994 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR01797
name: CDP-diacylglycerol + H(2)O = CMP + phosphatidate
namespace: reaction
xref: KEGG:R01797 "KEGG reaction"
xref: METACYC:CDPDIGLYPYPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15224 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol
relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate
relationship: has_output_compound UPa:UPC00416 ! phosphatidate
relationship: part_of UPa:UER00664 {cardinality="1", direction="LR", order="1"} ! phosphatidate from CDP-diacylglycerol: step 1/1
relationship: part_of UPa:UER00664 ! phosphatidate from CDP-diacylglycerol: step 1/1

[Term]
id: UPa:UCR01799
name: CTP + phosphatidate = CDP-diacylglycerol + diphosphate
namespace: reaction
xref: KEGG:R01799 "KEGG reaction"
xref: METACYC:CDPDIGLYSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16232 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00416 ! phosphatidate
relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol
relationship: has_output_compound UPa:UPC00269 ! CDP-diacylglycerol
relationship: part_of UPa:UER00614 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3
relationship: part_of UPa:UER00614 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3

[Term]
id: UPa:UCR01800
name: CDP-diacylglycerol + L-serine = CMP + phosphatidylserine
namespace: reaction
xref: KEGG:R01800 "KEGG reaction"
xref: METACYC:PHOSPHASERSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16916 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine
relationship: has_input_compound UPa:UPC00065 ! L-serine
relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol
relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC02737 ! phosphatidylserine
relationship: has_output_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine
relationship: part_of UPa:UER00615 ! phosphatidylethanolamine from CDP-diacylglycerol: step 1/2
relationship: part_of UPa:UER00615 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 1/2

[Term]
id: UPa:UCR01801
name: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + phosphatidylglycerophosphate
namespace: reaction
xref: KEGG:R01801 "KEGG reaction"
xref: METACYC:PHOSPHAGLYPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12596 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate
relationship: has_input_compound UPa:UPC00093 ! sn-glycerol 3-phosphate
relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol
relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate
relationship: has_output_compound UPa:UPC03892 ! phosphatidylglycerophosphate
relationship: part_of UPa:UER00503 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 1/2
relationship: part_of UPa:UER00503 ! phosphatidylglycerol from CDP-diacylglycerol: step 1/2

[Term]
id: UPa:UCR01811
name: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate
namespace: reaction
xref: KEGG:R01811 "KEGG reaction"
xref: METACYC:ACNEULY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23299 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00270 ! N-acetylneuraminate
relationship: has_input_compound UPa:UPC00270 {cardinality="1"} ! N-acetylneuraminate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine
relationship: has_output_compound UPa:UPC00645 ! N-acetyl-D-mannosamine
relationship: part_of UPa:UER00680 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 1/5
relationship: part_of UPa:UER00680 ! D-fructose 6-phosphate from N-acetylneuraminate: step 1/5

[Term]
id: UPa:UCR01812
name: 2 NADP(+) + tetrahydrobiopterin = 2 H(+) + 2 NADPH + biopterin
namespace: reaction
xref: KEGG:R01812 "KEGG reaction"
xref: METACYC:1.1.1.253-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19512 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC06313 ! biopterin
relationship: has_output_compound UPa:UPC06313 {cardinality="1"} ! biopterin
relationship: part_of UPa:UER00822 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from biopterin: step 1/1
relationship: part_of UPa:UER00822 ! tetrahydrobiopterin from biopterin: step 1/1

[Term]
id: UPa:UCR01813
name: NADP(+) + tetrahydrobiopterin = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
namespace: reaction
xref: KEGG:R01813 "KEGG reaction"
xref: METACYC:RXN-8854 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42503 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin
relationship: has_output_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin
relationship: part_of UPa:UER00821 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3
relationship: part_of UPa:UER00821 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3

[Term]
id: UPa:UCR01818
name: D-mannose 6-phosphate = alpha-D-mannose 1-phosphate
namespace: reaction
xref: KEGG:R01818 "KEGG reaction"
xref: METACYC:PHOSMANMUT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11143 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate
relationship: has_input_compound UPa:UPC00275 ! D-mannose 6-phosphate
relationship: has_output_compound UPa:UPC00636 ! alpha-D-mannose 1-phosphate
relationship: has_output_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate
relationship: part_of UPa:UER00424 {cardinality="1", direction="LR", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2
relationship: part_of UPa:UER00424 ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2

[Term]
id: UPa:UCR01825
name: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + H(+) + NADH
namespace: reaction
xref: KEGG:R01825 "KEGG reaction"
xref: METACYC:ERYTH4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12059 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate
relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate
relationship: has_output_compound UPa:UPC03393 ! 4-phospho-D-erythronate
relationship: part_of UPa:UER00309 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5
relationship: part_of UPa:UER00309 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5

[Term]
id: UPa:UCR01826
name: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate
namespace: reaction
xref: KEGG:R01826 "KEGG reaction"
xref: METACYC:DAHPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14720 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate
relationship: has_input_compound UPa:UPC00279 ! D-erythrose 4-phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
relationship: has_output_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
relationship: part_of UPa:UER00084 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7
relationship: part_of UPa:UER00084 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7

[Term]
id: UPa:UCR01827
name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate
namespace: reaction
xref: KEGG:R01827 "KEGG reaction"
xref: METACYC:TRANSALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17056 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC05382 ! sedoheptulose 7-phosphate
relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate
relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate
relationship: has_output_compound UPa:UPC00279 ! D-erythrose 4-phosphate
relationship: has_output_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate
relationship: part_of UPa:UER00414 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3
relationship: part_of UPa:UER00414 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3

[Term]
id: UPa:UCR01830
name: D-glyceraldehyde 3-phosphate + beta-D-fructose 6-phosphate = D-erythrose 4-phosphate + D-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R01830 "KEGG reaction"
xref: METACYC:2TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:27629 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate
relationship: has_input_compound UPa:UPC05345 ! beta-D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00279 ! D-erythrose 4-phosphate
relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate
relationship: part_of UPa:UER00415 ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3
relationship: part_of UPa:UER00415 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3

[Term]
id: UPa:UCR01859
name: ATP + bicarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + phosphate
namespace: reaction
xref: KEGG:R01859 "KEGG reaction"
xref: METACYC:PROPIONYL-COA-CARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23723 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00100 ! propanoyl-CoA
relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA
relationship: has_output_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA
relationship: part_of UPa:UER00908 ! succinyl-CoA from propanoyl-CoA: step 1/3
relationship: part_of UPa:UER00908 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 1/3

[Term]
id: UPa:UCR01867
name: (S)-dihydroorotate + fumarate = orotate + succinate
namespace: reaction
xref: KEGG:R01867 "KEGG reaction"
xref: METACYC:RXN-9929 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15444 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: has_input_compound UPa:UPC00122 ! fumarate
relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate
relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate
relationship: has_output_compound UPa:UPC00295 ! orotate
relationship: part_of UPa:UER00118 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (O2 route): step 1/1
relationship: part_of UPa:UER00118 ! orotate from (S)-dihydroorotate (O2 route): step 1/1

[Term]
id: UPa:UCR01868
name: (S)-dihydroorotate + Quinone = Hydroquinone + orotate
namespace: reaction
xref: KEGG:R01868 "KEGG reaction"
xref: METACYC:DIHYDROOROTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18076 "Rhea reaction"
xref: RHEA:30190 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate
relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate
relationship: has_input_compound UPa:UPC15602 ! Quinone
relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone
relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate
relationship: has_output_compound UPa:UPC00295 ! orotate
relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone
relationship: has_output_compound UPa:UPC15603 ! Hydroquinone
relationship: part_of UPa:UER00946 ! orotate from (S)-dihydroorotate (quinone route): step 1/1
relationship: part_of UPa:UER00946 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (quinone route): step 1/1

[Term]
id: UPa:UCR01869
name: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate
namespace: reaction
xref: KEGG:R01869 "KEGG reaction"
xref: METACYC:OROTATE-REDUCTASE-NADH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13516 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate
relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate
relationship: has_output_compound UPa:UPC00295 ! orotate
relationship: part_of UPa:UER00945 ! orotate from (S)-dihydroorotate (NAD(+) route): step 1/1
relationship: part_of UPa:UER00945 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (NAD(+) route): step 1/1

[Term]
id: UPa:UCR01870
name: diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
namespace: reaction
xref: KEGG:R01870 "KEGG reaction"
xref: METACYC:OROPRIBTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10383 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC01103 ! orotidine 5'-phosphate
relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate
relationship: has_output_compound UPa:UPC00295 ! orotate
relationship: part_of UPa:UER00119 {cardinality="1", direction="RL", order="1"} ! UMP from orotate: step 1/2
relationship: part_of UPa:UER00119 ! UMP from orotate: step 1/2

[Term]
id: UPa:UCR01872
name: D-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH
namespace: reaction
xref: KEGG:R01872 "KEGG reaction"
xref: METACYC:QUINATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: METACYC:RXN-7967 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:22367 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate
relationship: has_input_compound UPa:UPC00296 ! D-quinate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate
relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate
relationship: part_of UPa:UER00176 ! 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1
relationship: part_of UPa:UER00176 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1

[Term]
id: UPa:UCR01873
name: D-quinate + pyrroloquinoline quinone = 3-dehydroquinate + pyrroloquinoline quinol
namespace: reaction
xref: KEGG:R01873 "KEGG reaction"
xref: METACYC:1.1.99.25-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23675 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00113 {cardinality="1"} ! pyrroloquinoline quinone
relationship: has_input_compound UPa:UPC00113 ! pyrroloquinoline quinone
relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate
relationship: has_input_compound UPa:UPC00296 ! D-quinate
relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate
relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate
relationship: has_output_compound UPa:UPC01359 {cardinality="1"} ! pyrroloquinoline quinol
relationship: has_output_compound UPa:UPC01359 ! pyrroloquinoline quinol
relationship: part_of UPa:UER00177 ! 3-dehydroquinate from D-quinate (PQQ route): step 1/1
relationship: part_of UPa:UER00177 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (PQQ route): step 1/1

[Term]
id: UPa:UCR01876
name: phosphate + uridine = alpha-D-ribose 1-phosphate + uracil
namespace: reaction
xref: KEGG:R01876 "KEGG reaction"
xref: METACYC:URPHOS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24391 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine
relationship: has_input_compound UPa:UPC00299 ! uridine
relationship: has_output_compound UPa:UPC00106 ! uracil
relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil
relationship: has_output_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate
relationship: part_of UPa:UER00633 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (phosphorylase route): step 1/1
relationship: part_of UPa:UER00633 ! uracil from uridine (phosphorylase route): step 1/1

[Term]
id: UPa:UCR01878
name: H(2)O + cytidine = NH(3) + uridine
namespace: reaction
xref: KEGG:R01878 "KEGG reaction"
xref: METACYC:CYTIDEAM2-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16072 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine
relationship: has_input_compound UPa:UPC00475 ! cytidine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00299 ! uridine
relationship: has_output_compound UPa:UPC00299 {cardinality="1"} ! uridine
relationship: part_of UPa:UER00632 {cardinality="1", direction="LR", order="1"} ! uridine from cytidine: step 1/1
relationship: part_of UPa:UER00632 ! uridine from cytidine: step 1/1

[Term]
id: UPa:UCR01883
name: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
namespace: reaction
xref: KEGG:R01883 "KEGG reaction"
xref: METACYC:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10659 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00581 ! guanidinoacetate
relationship: has_input_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00300 {cardinality="1"} ! creatine
relationship: has_output_compound UPa:UPC00300 ! creatine
relationship: part_of UPa:UER00580 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 2/2
relationship: part_of UPa:UER00580 ! creatine from L-arginine and glycine: step 2/2

[Term]
id: UPa:UCR01890
name: CTP + phosphocholine = CDP-choline + diphosphate
namespace: reaction
xref: KEGG:R01890 "KEGG reaction"
xref: METACYC:2.7.7.15-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19000 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00588 ! phosphocholine
relationship: has_input_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00307 ! CDP-choline
relationship: has_output_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline
relationship: part_of UPa:UER00739 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 1/2
relationship: part_of UPa:UER00739 ! phosphatidylcholine from phosphocholine: step 1/2

[Term]
id: UPa:UCR01896
name: NAD(+) + xylitol = D-xylulose + H(+) + NADH
namespace: reaction
xref: KEGG:R01896 "KEGG reaction"
xref: METACYC:D-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20436 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol
relationship: has_input_compound UPa:UPC00379 ! xylitol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00310 ! D-xylulose
relationship: has_output_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose
relationship: part_of UPa:UER00577 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5
relationship: part_of UPa:UER00577 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5

[Term]
id: UPa:UCR01900
name: isocitrate = H(2)O + cis-aconitate
namespace: reaction
xref: KEGG:R01900 "KEGG reaction"
xref: METACYC:ACONITATEHYDR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22147 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00311 ! isocitrate
relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate
relationship: has_output_compound UPa:UPC00417 ! cis-aconitate
relationship: part_of UPa:UER00718 {cardinality="1", direction="RL", order="2"} ! isocitrate from oxaloacetate: step 2/2
relationship: part_of UPa:UER00718 ! isocitrate from oxaloacetate: step 2/2

[Term]
id: UPa:UCR01903
name: L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH
namespace: reaction
xref: KEGG:R01903 "KEGG reaction"
xref: METACYC:L-ARABINITOL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16384 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00532 ! L-arabinitol
relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00312 ! L-xylulose
relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose
relationship: part_of UPa:UER00575 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5
relationship: part_of UPa:UER00575 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5

[Term]
id: UPa:UCR01904
name: NADP(+) + xylitol = H(+) + L-xylulose + NADPH
namespace: reaction
xref: KEGG:R01904 "KEGG reaction"
xref: METACYC:L-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17028 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol
relationship: has_input_compound UPa:UPC00379 ! xylitol
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00312 ! L-xylulose
relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose
relationship: part_of UPa:UER00576 ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5
relationship: part_of UPa:UER00576 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5

[Term]
id: UPa:UCR01908
name: oxalyl-CoA = CO(2) + formyl-CoA
namespace: reaction
xref: KEGG:R01908 "KEGG reaction"
xref: METACYC:OXALYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19336 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA
relationship: has_input_compound UPa:UPC00313 ! oxalyl-CoA
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00798 ! formyl-CoA
relationship: has_output_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA
relationship: part_of UPa:UER00599 ! CO(2) and formate from oxalate: step 2/2
relationship: part_of UPa:UER00599 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 2/2

[Term]
id: UPa:UCR01909
name: ATP + pyridoxine = ADP + pyridoxine 5'-phosphate
namespace: reaction
xref: KEGG:R01909 "KEGG reaction"
xref: METACYC:PNKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25111 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine
relationship: has_input_compound UPa:UPC00314 ! pyridoxine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate
relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate
relationship: part_of UPa:UER00300 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from pyridoxine: step 1/1
relationship: part_of UPa:UER00300 ! pyridoxine 5'-phosphate from pyridoxine: step 1/1

[Term]
id: UPa:UCR01911
name: phosphate + pyridoxine = H(2)O + pyridoxine 5'-phosphate
namespace: reaction
xref: KEGG:R01911 "KEGG reaction"
xref: RHEA:25115 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00314 ! pyridoxine
relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate
relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate
relationship: part_of UPa:UER00303 ! pyridoxine from pyridoxine 5'-phosphate: step 1/1
relationship: part_of UPa:UER00303 {cardinality="1", direction="RL", order="1"} ! pyridoxine from pyridoxine 5'-phosphate: step 1/1

[Term]
id: UPa:UCR01915
name: H(2)O + acceptor + spermidine = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor
namespace: reaction
xref: KEGG:R01915 "KEGG reaction"
xref: METACYC:SPERMIDINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14276 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine
relationship: has_input_compound UPa:UPC00315 ! spermidine
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal
relationship: has_output_compound UPa:UPC00555 ! 4-aminobutanal
relationship: has_output_compound UPa:UPC00986 ! 1,3-diaminopropane
relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane
relationship: part_of UPa:UER00291 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1
relationship: part_of UPa:UER00291 ! 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1

[Term]
id: UPa:UCR01920
name: S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine
namespace: reaction
xref: KEGG:R01920 "KEGG reaction"
xref: METACYC:SPERMIDINESYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12724 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine
relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine
relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00315 ! spermidine
relationship: has_output_compound UPa:UPC00315 {cardinality="1"} ! spermidine
relationship: part_of UPa:UER00314 ! spermidine from putrescine: step 1/1
relationship: part_of UPa:UER00314 {cardinality="1", direction="LR", order="1"} ! spermidine from putrescine: step 1/1

[Term]
id: UPa:UCR01936
name: 2-oxaloglutaric acid = 2-oxoadipate + CO(2)
namespace: reaction
xref: KEGG:R01936 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid
relationship: has_input_compound UPa:UPC05533 ! 2-oxaloglutaric acid
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate
relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate
relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="2"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5
relationship: part_of UPa:UER00030 ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5

[Term]
id: UPa:UCR01939
name: 2-oxoglutarate + L-alpha-aminoadipate = 2-oxoadipate + L-glutamate
namespace: reaction
xref: KEGG:R01939 "KEGG reaction"
xref: METACYC:2-AMINOADIPATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12604 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate
relationship: has_output_compound UPa:UPC00322 ! 2-oxoadipate
relationship: part_of UPa:UER00031 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 5/5
relationship: part_of UPa:UER00031 ! L-alpha-aminoadipate from 2-oxoglutarate: step 5/5
relationship: part_of UPa:UER00838 ! glutaryl-CoA from L-lysine: step 4/6
relationship: part_of UPa:UER00838 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 4/6

[Term]
id: UPa:UCR01940
name: 2-oxoadipate + Enzyme N6-(lipoyl)lysine = CO(2) + S(8)-glutaryldihydrolipoamide
namespace: reaction
xref: KEGG:R01940 "KEGG reaction"
xref: RHEA:12191 "Rhea reaction"
xref: RHEA:15216 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate
relationship: has_input_compound UPa:UPC00322 ! 2-oxoadipate
relationship: has_input_compound UPa:UPC15972 ! Enzyme N6-(lipoyl)lysine
relationship: has_input_compound UPa:UPC15972 {cardinality="1"} ! Enzyme N6-(lipoyl)lysine
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide
relationship: has_output_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide
relationship: part_of UPa:UER00839 ! glutaryl-CoA from L-lysine: step 5/6
relationship: part_of UPa:UER00839 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 5/6

[Term]
id: UPa:UCR01954
name: ATP + L-aspartate + L-citrulline = (N(omega)-L-arginino)succinate + AMP + diphosphate
namespace: reaction
xref: KEGG:R01954 "KEGG reaction"
xref: METACYC:ARGSUCCINSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10935 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00327 ! L-citrulline
relationship: has_input_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC03406 ! (N(omega)-L-arginino)succinate
relationship: has_output_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate
relationship: part_of UPa:UER00113 ! L-arginine from L-ornithine and carbamoyl phosphate: step 2/3
relationship: part_of UPa:UER00113 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 2/3
relationship: part_of UPa:UER00272 {cardinality="1", direction="LR", order="1"} ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1
relationship: part_of UPa:UER00272 ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1

[Term]
id: UPa:UCR01956
name: 2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
namespace: reaction
xref: KEGG:R01956 "KEGG reaction"
xref: METACYC:2.6.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20967 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00328 ! L-kynurenine
relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate
relationship: has_output_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate
relationship: part_of UPa:UER00726 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 1/2
relationship: part_of UPa:UER00726 ! kynurenate from L-kynurenine: step 1/2

[Term]
id: UPa:UCR01959
name: H(2)O + N-formyl-N-kynurenine = L-kynurenine + formate
namespace: reaction
xref: KEGG:R01959 "KEGG reaction"
xref: METACYC:ARYLFORMAMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13012 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02700 ! N-formyl-N-kynurenine
relationship: has_input_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine
relationship: has_output_compound UPa:UPC00328 ! L-kynurenine
relationship: part_of UPa:UER00454 ! L-kynurenine from L-tryptophan: step 2/2
relationship: part_of UPa:UER00454 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 2/2

[Term]
id: UPa:UCR01960
name: H(+) + L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R01960 "KEGG reaction"
xref: METACYC:KYNURENINE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20548 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine
relationship: has_input_compound UPa:UPC00328 ! L-kynurenine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine
relationship: has_output_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine
relationship: part_of UPa:UER00328 ! quinolinate from L-kynurenine: step 1/3
relationship: part_of UPa:UER00328 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 1/3

[Term]
id: UPa:UCR01978
name: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = H(2)O + acetoacetyl-CoA + acetyl-CoA
namespace: reaction
xref: KEGG:R01978 "KEGG reaction"
xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10191 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA
relationship: has_output_compound UPa:UPC00332 ! acetoacetyl-CoA
relationship: part_of UPa:UER00102 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 2/3
relationship: part_of UPa:UER00102 ! (R)-mevalonate from acetyl-CoA: step 2/3

[Term]
id: UPa:UCR01993
name: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate
namespace: reaction
xref: KEGG:R01993 "KEGG reaction"
xref: METACYC:DIHYDROOROT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24299 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate
relationship: has_input_compound UPa:UPC00337 ! (S)-dihydroorotate
relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate
relationship: has_output_compound UPa:UPC00438 ! N-carbamoyl-L-aspartate
relationship: part_of UPa:UER00117 ! (S)-dihydroorotate from bicarbonate: step 3/3
relationship: part_of UPa:UER00117 {cardinality="1", direction="RL", order="1"} ! (S)-dihydroorotate from bicarbonate: step 3/3

[Term]
id: UPa:UCR02003
name: geranyl diphosphate + isopentenyl diphosphate = diphosphate + farnesyl diphosphate
namespace: reaction
xref: KEGG:R02003 "KEGG reaction"
xref: METACYC:FPPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19364 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: part_of UPa:UER00369 {cardinality="1", direction="LR", order="1"} ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1
relationship: part_of UPa:UER00369 ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1

[Term]
id: UPa:UCR02013
name: geranyl diphosphate = (4S)-limonene + diphosphate
namespace: reaction
xref: KEGG:R02013 "KEGG reaction"
xref: METACYC:4.2.3.16-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12872 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00521 {cardinality="1"} ! (4S)-limonene
relationship: has_output_compound UPa:UPC00521 ! (4S)-limonene
relationship: part_of UPa:UER00925 {cardinality="1", direction="LR", order="1"} ! (4S)-limonene from geranyl diphosphate: step 1/1
relationship: part_of UPa:UER00925 ! (4S)-limonene from geranyl diphosphate: step 1/1

[Term]
id: UPa:UCR02021
name: 3'-phospho-5'-adenylyl sulfate + thioredoxin = adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide
namespace: reaction
xref: KEGG:R02021 "KEGG reaction"
xref: METACYC:1.8.4.8-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11727 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate
relationship: has_input_compound UPa:UPC00053 ! 3'-phospho-5'-adenylyl sulfate
relationship: has_input_compound UPa:UPC00342 ! thioredoxin
relationship: has_input_compound UPa:UPC00342 {cardinality="1"} ! thioredoxin
relationship: has_output_compound UPa:UPC00054 {cardinality="1"} ! adenosine 3',5'-bisphosphate
relationship: has_output_compound UPa:UPC00054 ! adenosine 3',5'-bisphosphate
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: has_output_compound UPa:UPC00343 ! thioredoxin disulfide
relationship: has_output_compound UPa:UPC00343 {cardinality="1"} ! thioredoxin disulfide
relationship: part_of UPa:UER00206 ! sulfite from sulfate: step 3/3
relationship: part_of UPa:UER00206 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 3/3

[Term]
id: UPa:UCR02029
name: H(2)O + phosphatidylglycerophosphate = phosphate + phosphatidylglycerol
namespace: reaction
xref: KEGG:R02029 "KEGG reaction"
xref: METACYC:PGPPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:33754 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate
relationship: has_input_compound UPa:UPC03892 ! phosphatidylglycerophosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00344 ! phosphatidylglycerol
relationship: has_output_compound UPa:UPC00344 {cardinality="1"} ! phosphatidylglycerol
relationship: part_of UPa:UER00504 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 2/2
relationship: part_of UPa:UER00504 ! phosphatidylglycerol from CDP-diacylglycerol: step 2/2

[Term]
id: UPa:UCR02035
name: D-glucono-1,5-lactone 6-phosphate + H(2)O = 6-phospho-D-gluconate
namespace: reaction
xref: KEGG:R02035 "KEGG reaction"
xref: METACYC:6PGLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12559 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate
relationship: has_input_compound UPa:UPC01236 ! D-glucono-1,5-lactone 6-phosphate
relationship: has_output_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate
relationship: has_output_compound UPa:UPC00345 ! 6-phospho-D-gluconate
relationship: part_of UPa:UER00409 ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3
relationship: part_of UPa:UER00409 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3

[Term]
id: UPa:UCR02037
name: S-adenosyl-L-methionine + phosphoethanolamine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R02037 "KEGG reaction"
xref: METACYC:2.1.1.103-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20368 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine
relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC01210 ! N-methylethanolamine phosphate
relationship: has_output_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate
relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="1"} ! phosphocholine from phosphoethanolamine: step 1/1
relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1

[Term]
id: UPa:UCR02038
name: CTP + phosphoethanolamine = CDP-ethanolamine + diphosphate
namespace: reaction
xref: KEGG:R02038 "KEGG reaction"
xref: METACYC:2.7.7.14-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24595 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine
relationship: has_input_compound UPa:UPC00346 ! phosphoethanolamine
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine
relationship: has_output_compound UPa:UPC00570 ! CDP-ethanolamine
relationship: part_of UPa:UER00742 ! phosphatidylethanolamine from ethanolamine: step 2/3
relationship: part_of UPa:UER00742 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 2/3

[Term]
id: UPa:UCR02055
name: phosphatidylserine = CO(2) + phosphatidylethanolamine
namespace: reaction
xref: KEGG:R02055 "KEGG reaction"
xref: METACYC:PHOSPHASERDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20831 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02737 ! phosphatidylserine
relationship: has_input_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine
relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine
relationship: part_of UPa:UER00616 ! phosphatidylethanolamine from CDP-diacylglycerol: step 2/2
relationship: part_of UPa:UER00616 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 2/2

[Term]
id: UPa:UCR02057
name: 1,2-diacyl-sn-glycerol + CDP-ethanolamine = CMP + phosphatidylethanolamine
namespace: reaction
xref: KEGG:R02057 "KEGG reaction"
xref: METACYC:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:32946 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00570 ! CDP-ethanolamine
relationship: has_input_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine
relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol
relationship: has_input_compound UPa:UPC00641 ! 1,2-diacyl-sn-glycerol
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine
relationship: has_output_compound UPa:UPC00350 ! phosphatidylethanolamine
relationship: part_of UPa:UER00743 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 3/3
relationship: part_of UPa:UER00743 ! phosphatidylethanolamine from ethanolamine: step 3/3

[Term]
id: UPa:UCR02058
name: acetyl-CoA + alpha-D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
namespace: reaction
xref: KEGG:R02058 "KEGG reaction"
xref: METACYC:GLUCOSAMINEPNACETYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10295 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate
relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate
relationship: part_of UPa:UER00529 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2
relationship: part_of UPa:UER00529 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2

[Term]
id: UPa:UCR02059
name: H(2)O + N-acetyl-D-glucosamine 6-phosphate = acetate + alpha-D-glucosamine 6-phosphate
namespace: reaction
xref: KEGG:R02059 "KEGG reaction"
xref: METACYC:NAG6PDEACET-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22939 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate
relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate
relationship: part_of UPa:UER00683 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 4/5
relationship: part_of UPa:UER00683 ! D-fructose 6-phosphate from N-acetylneuraminate: step 4/5

[Term]
id: UPa:UCR02060
name: alpha-D-glucosamine 1-phosphate = alpha-D-glucosamine 6-phosphate
namespace: reaction
xref: KEGG:R02060 "KEGG reaction"
xref: METACYC:5.4.2.10-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23427 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate
relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC00352 ! alpha-D-glucosamine 6-phosphate
relationship: part_of UPa:UER00531 {cardinality="1", direction="RL", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2
relationship: part_of UPa:UER00531 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2

[Term]
id: UPa:UCR02061
name: farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate
namespace: reaction
xref: KEGG:R02061 "KEGG reaction"
xref: METACYC:FARNESYLTRANSTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17656 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate
relationship: has_output_compound UPa:UPC00353 ! geranylgeranyl diphosphate
relationship: part_of UPa:UER00564 {cardinality="1", direction="LR", order="1"} ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1
relationship: part_of UPa:UER00564 ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1

[Term]
id: UPa:UCR02065
name: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate
namespace: reaction
xref: KEGG:R02065 "KEGG reaction"
xref: METACYC:2.5.1.32-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22299 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate
relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate
relationship: has_output_compound UPa:UPC03427 ! prephytoene diphosphate
relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="1"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1
relationship: part_of UPa:UER01030 ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1

[Term]
id: UPa:UCR02080
name: L-dopa = CO(2) + dopamine
namespace: reaction
xref: KEGG:R02080 "KEGG reaction"
xref: METACYC:RXN66-221 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12275 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00355 {cardinality="1"} ! L-dopa
relationship: has_input_compound UPa:UPC00355 ! L-dopa
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC03758 {cardinality="1"} ! dopamine
relationship: has_output_compound UPa:UPC03758 ! dopamine
relationship: part_of UPa:UER00734 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 2/2
relationship: part_of UPa:UER00734 ! dopamine from L-tyrosine: step 2/2

[Term]
id: UPa:UCR02081
name: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH
namespace: reaction
xref: KEGG:R02081 "KEGG reaction"
xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14836 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate
relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: part_of UPa:UER00367 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1
relationship: part_of UPa:UER00367 ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1

[Term]
id: UPa:UCR02082
name: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
namespace: reaction
xref: KEGG:R02082 "KEGG reaction"
xref: METACYC:1.1.1.34-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15992 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate
relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_output_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: part_of UPa:UER00103 ! (R)-mevalonate from acetyl-CoA: step 3/3
relationship: part_of UPa:UER00103 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 3/3

[Term]
id: UPa:UCR02085
name: (S)-3-hydroxy-3-methylglutaryl-CoA = 3-methylglutaconyl-CoA + H(2)O
namespace: reaction
xref: KEGG:R02085 "KEGG reaction"
xref: METACYC:METHYLGLUTACONYL-COA-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21539 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_input_compound UPa:UPC00356 ! (S)-3-hydroxy-3-methylglutaryl-CoA
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA
relationship: has_output_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA
relationship: part_of UPa:UER00862 {cardinality="1", direction="RL", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3
relationship: part_of UPa:UER00862 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3

[Term]
id: UPa:UCR02087
name: N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate
namespace: reaction
xref: KEGG:R02087 "KEGG reaction"
xref: METACYC:NANE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25260 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate
relationship: has_input_compound UPa:UPC00357 ! N-acetyl-D-glucosamine 6-phosphate
relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate
relationship: has_output_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate
relationship: part_of UPa:UER00682 ! D-fructose 6-phosphate from N-acetylneuraminate: step 3/5
relationship: part_of UPa:UER00682 {cardinality="1", direction="RL", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 3/5

[Term]
id: UPa:UCR02100
name: H(2)O + dUTP = dUMP + diphosphate
namespace: reaction
xref: KEGG:R02100 "KEGG reaction"
xref: METACYC:DUTP-PYROP-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10251 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00460 {cardinality="1"} ! dUTP
relationship: has_input_compound UPa:UPC00460 ! dUTP
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00365 ! dUMP
relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP
relationship: part_of UPa:UER00666 ! dUMP from dCTP (dUTP route): step 2/2
relationship: part_of UPa:UER00666 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 2/2

[Term]
id: UPa:UCR02103
name: H(2)O + NAD(+) + xanthine = H(+) + NADH + urate
namespace: reaction
xref: KEGG:R02103 "KEGG reaction"
xref: METACYC:RXN0-901 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16672 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00385 ! xanthine
relationship: has_input_compound UPa:UPC00385 {cardinality="1"} ! xanthine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00366 ! urate
relationship: has_output_compound UPa:UPC00366 {cardinality="1"} ! urate
relationship: part_of UPa:UER00662 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 2/2
relationship: part_of UPa:UER00662 ! urate from hypoxanthine: step 2/2

[Term]
id: UPa:UCR02106
name: H(2)O + O(2) + urate = 5-hydroxyisouric acid + H(2)O(2)
namespace: reaction
xref: KEGG:R02106 "KEGG reaction"
xref: METACYC:URATE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21371 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00366 ! urate
relationship: has_input_compound UPa:UPC00366 {cardinality="1"} ! urate
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid
relationship: has_output_compound UPa:UPC11821 ! 5-hydroxyisouric acid
relationship: part_of UPa:UER00650 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 1/3
relationship: part_of UPa:UER00650 ! (S)-allantoin from urate: step 1/3

[Term]
id: UPa:UCR02133
name: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)
namespace: reaction
xref: KEGG:R02133 "KEGG reaction"
xref: METACYC:THIAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17512 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine
relationship: has_input_compound UPa:UPC00378 ! thiamine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine
relationship: has_output_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine
relationship: has_output_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole
relationship: has_output_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole
relationship: part_of UPa:UER00805 {cardinality="1", direction="LR", order="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1
relationship: part_of UPa:UER00805 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1

[Term]
id: UPa:UCR02134
name: ATP + thiamine = ADP + thiamine phosphate
namespace: reaction
xref: KEGG:R02134 "KEGG reaction"
xref: METACYC:THIKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12015 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine
relationship: has_input_compound UPa:UPC00378 ! thiamine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate
relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate
relationship: part_of UPa:UER00596 ! thiamine phosphate from thiamine: step 1/1
relationship: part_of UPa:UER00596 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from thiamine: step 1/1

[Term]
id: UPa:UCR02139
name: H(2)O + barbiturate = 3-oxo-3-ureidopropanoic acid
namespace: reaction
xref: KEGG:R02139 "KEGG reaction"
xref: METACYC:BARBITURASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18656 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00813 {cardinality="1"} ! barbiturate
relationship: has_input_compound UPa:UPC00813 ! barbiturate
relationship: has_output_compound UPa:UPC15607 ! 3-oxo-3-ureidopropanoic acid
relationship: has_output_compound UPa:UPC15607 {cardinality="1"} ! 3-oxo-3-ureidopropanoic acid
relationship: part_of UPa:UER00644 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 2/3
relationship: part_of UPa:UER00644 ! malonate and urea from uracil: step 2/3

[Term]
id: UPa:UCR02142
name: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
namespace: reaction
xref: KEGG:R02142 "KEGG reaction"
xref: METACYC:XANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10803 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00655 ! XMP
relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00385 ! xanthine
relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine
relationship: part_of UPa:UER00658 {cardinality="1", direction="RL", order="1"} ! XMP from xanthine: step 1/1
relationship: part_of UPa:UER00658 ! XMP from xanthine: step 1/1

[Term]
id: UPa:UCR02164
name: Quinone + succinate = Hydroquinone + fumarate
namespace: reaction
xref: KEGG:R02164 "KEGG reaction"
xref: METACYC:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13716 "Rhea reaction"
xref: RHEA:40526 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00042 ! succinate
relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone
relationship: has_input_compound UPa:UPC15602 ! Quinone
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone
relationship: has_output_compound UPa:UPC15603 ! Hydroquinone
relationship: part_of UPa:UER01006 ! fumarate from succinate (eukaryal route): step 1/1
relationship: part_of UPa:UER01006 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (eukaryal route): step 1/1

[Term]
id: UPa:UCR02199
name: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
namespace: reaction
xref: KEGG:R02199 "KEGG reaction"
xref: METACYC:BRANCHED-CHAINAMINOTRANSFERILEU-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24804 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00407 {cardinality="1"} ! L-isoleucine
relationship: has_input_compound UPa:UPC00407 ! L-isoleucine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate
relationship: part_of UPa:UER00058 ! L-isoleucine from 2-oxobutanoate: step 4/4
relationship: part_of UPa:UER00058 {cardinality="1", direction="RL", order="1"} ! L-isoleucine from 2-oxobutanoate: step 4/4

[Term]
id: UPa:UCR02236
name: 7,8-dihydrofolate + NADP(+) = H(+) + NADPH + folate
namespace: reaction
xref: KEGG:R02236 "KEGG reaction"
xref: RHEA:31106 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate
relationship: has_input_compound UPa:UPC00415 ! 7,8-dihydrofolate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00504 {cardinality="1"} ! folate
relationship: has_output_compound UPa:UPC00504 ! folate
relationship: part_of UPa:UER00818 {cardinality="1", direction="RL", order="1"} ! 7,8-dihydrofolate from folate: step 1/1
relationship: part_of UPa:UER00818 ! 7,8-dihydrofolate from folate: step 1/1

[Term]
id: UPa:UCR02237
name: 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + phosphate
namespace: reaction
xref: KEGG:R02237 "KEGG reaction"
xref: METACYC:DIHYDROFOLATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23587 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00921 ! 7,8-dihydropteroate
relationship: has_input_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00415 ! 7,8-dihydrofolate
relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate
relationship: part_of UPa:UER00157 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2
relationship: part_of UPa:UER00157 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2

[Term]
id: UPa:UCR02241
name: CoA + phosphatidate = 1-acyl-sn-glycerol 3-phosphate + acyl-CoA
namespace: reaction
xref: KEGG:R02241 "KEGG reaction"
xref: METACYC:RXN-1623 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19712 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00416 ! phosphatidate
relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate
relationship: has_output_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA
relationship: has_output_compound UPa:UPC00040 ! acyl-CoA
relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate
relationship: has_output_compound UPa:UPC00681 ! 1-acyl-sn-glycerol 3-phosphate
relationship: part_of UPa:UER00613 {cardinality="1", direction="RL", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3
relationship: part_of UPa:UER00613 ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3

[Term]
id: UPa:UCR02245
name: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP
namespace: reaction
xref: KEGG:R02245 "KEGG reaction"
xref: METACYC:MEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17068 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate
relationship: has_input_compound UPa:UPC00418 ! (R)-mevalonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01107 ! (R)-5-phosphomevalonate
relationship: has_output_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate
relationship: part_of UPa:UER00098 ! isopentenyl diphosphate from (R)-mevalonate: step 1/3
relationship: part_of UPa:UER00098 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 1/3

[Term]
id: UPa:UCR02253
name: H(+) + NADPH + O(2) + trans-cinnamate = H(2)O + NADP(+) + trans-4-coumarate
namespace: reaction
xref: KEGG:R02253 "KEGG reaction"
xref: METACYC:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10611 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00423 ! trans-cinnamate
relationship: has_input_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate
relationship: has_output_compound UPa:UPC00811 ! trans-4-coumarate
relationship: part_of UPa:UER00789 {cardinality="1", direction="LR", order="1"} ! trans-4-coumarate from trans-cinnamate: step 1/1
relationship: part_of UPa:UER00789 ! trans-4-coumarate from trans-cinnamate: step 1/1

[Term]
id: UPa:UCR02262
name: L-fuculose 1-phosphate = L-lactaldehyde + glycerone phosphate
namespace: reaction
xref: KEGG:R02262 "KEGG reaction"
xref: METACYC:FUCPALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12936 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate
relationship: has_input_compound UPa:UPC01099 ! L-fuculose 1-phosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde
relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde
relationship: part_of UPa:UER00626 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3
relationship: part_of UPa:UER00626 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3

[Term]
id: UPa:UCR02263
name: L-rhamnulose 1-phosphate = L-lactaldehyde + glycerone phosphate
namespace: reaction
xref: KEGG:R02263 "KEGG reaction"
xref: METACYC:RHAMNULPALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19692 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate
relationship: has_input_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde
relationship: has_output_compound UPa:UPC00424 ! L-lactaldehyde
relationship: part_of UPa:UER00603 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 3/3
relationship: part_of UPa:UER00603 ! glycerone phosphate from L-rhamnose: step 3/3

[Term]
id: UPa:UCR02272
name: 5-aminolevulinate = (S)-4-amino-5-oxopentanoic acid
namespace: reaction
xref: KEGG:R02272 "KEGG reaction"
xref: METACYC:GSAAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14268 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate
relationship: has_input_compound UPa:UPC00430 ! 5-aminolevulinate
relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid
relationship: has_output_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid
relationship: part_of UPa:UER00317 {cardinality="1", direction="RL", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2
relationship: part_of UPa:UER00317 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2

[Term]
id: UPa:UCR02274
name: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate
namespace: reaction
xref: KEGG:R02274 "KEGG reaction"
xref: METACYC:VAGL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10215 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00431 ! 5-aminopentanoate
relationship: has_input_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC03273 ! 5-oxopentanoate
relationship: has_output_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate
relationship: part_of UPa:UER00845 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 5/6
relationship: part_of UPa:UER00845 ! glutarate from L-lysine: step 5/6

[Term]
id: UPa:UCR02276
name: 5-acetamidopentanoate + H(2)O = 5-aminopentanoate + acetate
namespace: reaction
xref: KEGG:R02276 "KEGG reaction"
xref: METACYC:AMVAL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42515 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC03087 ! 5-acetamidopentanoate
relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00431 ! 5-aminopentanoate
relationship: has_output_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate
relationship: part_of UPa:UER00844 ! glutarate from L-lysine: step 4/6
relationship: part_of UPa:UER00844 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 4/6

[Term]
id: UPa:UCR02278
name: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O
namespace: reaction
xref: KEGG:R02278 "KEGG reaction"
xref: METACYC:4.2.1.43-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17204 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate
relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate
relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate
relationship: part_of UPa:UER00572 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2
relationship: part_of UPa:UER00572 ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2

[Term]
id: UPa:UCR02279
name: 5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + CO(2) + H(2)O
namespace: reaction
xref: KEGG:R02279 "KEGG reaction"
xref: METACYC:4.2.1.41-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24611 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00433 ! 2,5-dioxopentanoate
relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate
relationship: part_of UPa:UER00628 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 2/2
relationship: part_of UPa:UER00628 ! 2,5-dioxopentanoate from D-glucarate: step 2/2

[Term]
id: UPa:UCR02282
name: L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate
namespace: reaction
xref: KEGG:R02282 "KEGG reaction"
xref: METACYC:GLUTAMATE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15352 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine
relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine
relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine
relationship: has_output_compound UPa:UPC00077 ! L-ornithine
relationship: has_output_compound UPa:UPC00624 ! N-acetyl-L-glutamate
relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate
relationship: part_of UPa:UER00111 {cardinality="1", direction="LR", order="1"} ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1
relationship: part_of UPa:UER00111 ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1

[Term]
id: UPa:UCR02283
name: 2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde
namespace: reaction
xref: KEGG:R02283 "KEGG reaction"
xref: METACYC:ACETYLORNTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18052 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00437 ! N(2)-acetyl-L-ornithine
relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde
relationship: part_of UPa:UER00109 ! N(2)-acetyl-L-ornithine from L-glutamate: step 4/4
relationship: part_of UPa:UER00109 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 4/4

[Term]
id: UPa:UCR02285
name: H(2)O + N-formimidoyl-L-glutamate = L-glutamate + formamide
namespace: reaction
xref: KEGG:R02285 "KEGG reaction"
xref: METACYC:FORMIMINOGLUTAMASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22495 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate
relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00488 {cardinality="1"} ! formamide
relationship: has_output_compound UPa:UPC00488 ! formamide
relationship: part_of UPa:UER00552 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1
relationship: part_of UPa:UER00552 ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1

[Term]
id: UPa:UCR02286
name: H(2)O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH(3)
namespace: reaction
xref: KEGG:R02286 "KEGG reaction"
xref: METACYC:FORMIMINOGLUTAMATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22835 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate
relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate
relationship: has_output_compound UPa:UPC01045 ! N-formyl-L-glutamate
relationship: part_of UPa:UER00553 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2
relationship: part_of UPa:UER00553 ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2

[Term]
id: UPa:UCR02287
name: 5-formiminotetrahydrofolate + L-glutamate = 5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate
namespace: reaction
xref: KEGG:R02287 "KEGG reaction"
xref: METACYC:GLUTAMATE-FORMIMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15100 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00664 ! 5-formiminotetrahydrofolate
relationship: has_input_compound UPa:UPC00664 {cardinality="1"} ! 5-formiminotetrahydrofolate
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate
relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate
relationship: part_of UPa:UER00555 {cardinality="1", direction="RL", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1
relationship: part_of UPa:UER00555 ! L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1

[Term]
id: UPa:UCR02288
name: 4-imidazolone-5-propanoate + H(2)O = N-formimidoyl-L-glutamate
namespace: reaction
xref: KEGG:R02288 "KEGG reaction"
xref: METACYC:IMIDAZOLONEPROPIONASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23663 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate
relationship: has_input_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate
relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate
relationship: has_output_compound UPa:UPC00439 ! N-formimidoyl-L-glutamate
relationship: part_of UPa:UER00551 ! N-formimidoyl-L-glutamate from L-histidine: step 3/3
relationship: part_of UPa:UER00551 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 3/3

[Term]
id: UPa:UCR02291
name: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH
namespace: reaction
xref: KEGG:R02291 "KEGG reaction"
xref: METACYC:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24287 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde
relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate
relationship: has_output_compound UPa:UPC03082 ! 4-phospho-L-aspartate
relationship: part_of UPa:UER00016 ! (S)-tetrahydrodipicolinate from L-aspartate: step 2/4
relationship: part_of UPa:UER00016 {cardinality="1", direction="RL", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 2/4
relationship: part_of UPa:UER00463 {cardinality="1", direction="RL", order="1"} ! L-threonine from L-aspartate: step 2/5
relationship: part_of UPa:UER00463 ! L-threonine from L-aspartate: step 2/5
relationship: part_of UPa:UER00464 {cardinality="1", direction="RL", order="1"} ! L-homoserine from L-aspartate: step 2/3
relationship: part_of UPa:UER00464 ! L-homoserine from L-aspartate: step 2/3

[Term]
id: UPa:UCR02305
name: farnesyl diphosphate = diphosphate + pentalenene
namespace: reaction
xref: KEGG:R02305 "KEGG reaction"
xref: METACYC:PENTALENENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18084 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC01841 {cardinality="1"} ! pentalenene
relationship: has_output_compound UPa:UPC01841 ! pentalenene
relationship: part_of UPa:UER00581 {cardinality="1", direction="LR", order="1"} ! pentalenene from farnesyl diphosphate: step 1/1
relationship: part_of UPa:UER00581 ! pentalenene from farnesyl diphosphate: step 1/1

[Term]
id: UPa:UCR02307
name: farnesyl diphosphate = aristolochene + diphosphate
namespace: reaction
xref: KEGG:R02307 "KEGG reaction"
xref: METACYC:ARISTOLOCHENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19828 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC02004 ! aristolochene
relationship: has_output_compound UPa:UPC02004 {cardinality="1"} ! aristolochene
relationship: part_of UPa:UER00582 ! aristolochene from farnesyl diphosphate: step 1/1
relationship: part_of UPa:UER00582 {cardinality="1", direction="LR", order="1"} ! aristolochene from farnesyl diphosphate: step 1/1

[Term]
id: UPa:UCR02313
name: H(2)O + NAD(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADH
namespace: reaction
xref: KEGG:R02313 "KEGG reaction"
xref: METACYC:1.5.1.9-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24523 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00449 ! saccharopine
relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde
relationship: part_of UPa:UER00836 ! glutaryl-CoA from L-lysine: step 2/6
relationship: part_of UPa:UER00836 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 2/6

[Term]
id: UPa:UCR02315
name: H(2)O + NADP(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADPH
namespace: reaction
xref: KEGG:R02315 "KEGG reaction"
xref: METACYC:RXN3O-127 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10023 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00449 ! saccharopine
relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde
relationship: part_of UPa:UER00033 ! L-lysine from L-alpha-aminoadipate (fungal route): step 2/3
relationship: part_of UPa:UER00033 {cardinality="1", direction="RL", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 2/3

[Term]
id: UPa:UCR02325
name: H(2)O + dCTP = NH(3) + dUTP
namespace: reaction
xref: KEGG:R02325 "KEGG reaction"
xref: METACYC:DCTP-DEAM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22683 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP
relationship: has_input_compound UPa:UPC00458 ! dCTP
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00460 {cardinality="1"} ! dUTP
relationship: has_output_compound UPa:UPC00460 ! dUTP
relationship: part_of UPa:UER00665 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 1/2
relationship: part_of UPa:UER00665 ! dUMP from dCTP (dUTP route): step 1/2

[Term]
id: UPa:UCR02340
name: indoleglycerol phosphate = D-glyceraldehyde 3-phosphate + indole
namespace: reaction
xref: KEGG:R02340 "KEGG reaction"
xref: METACYC:RXN0-2381 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14084 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03506 ! indoleglycerol phosphate
relationship: has_input_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole
relationship: has_output_compound UPa:UPC00463 ! indole
relationship: part_of UPa:UER00044 ! L-tryptophan from chorismate: step 5/5
relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 5/5
relationship: part_of UPa:UER00847 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5
relationship: part_of UPa:UER00847 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5

[Term]
id: UPa:UCR02362
name: n H(2)O + pectin = n methanol + pectate
namespace: reaction
xref: KEGG:R02362 "KEGG reaction"
xref: METACYC:PECTINESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00714 {cardinality="1"} ! pectin
relationship: has_input_compound UPa:UPC00714 ! pectin
relationship: has_output_compound UPa:UPC00132 ! methanol
relationship: has_output_compound UPa:UPC00132 {cardinality="1"} ! methanol
relationship: has_output_compound UPa:UPC00470 {cardinality="1"} ! pectate
relationship: has_output_compound UPa:UPC00470 ! pectate
relationship: part_of UPa:UER00823 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5
relationship: part_of UPa:UER00823 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5

[Term]
id: UPa:UCR02401
name: 5-oxopentanoate + H(2)O + NAD(+) = H(+) + NADH + glutarate
namespace: reaction
xref: KEGG:R02401 "KEGG reaction"
xref: METACYC:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12067 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC03273 ! 5-oxopentanoate
relationship: has_input_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00489 ! glutarate
relationship: has_output_compound UPa:UPC00489 {cardinality="1"} ! glutarate
relationship: part_of UPa:UER00846 ! glutarate from L-lysine: step 6/6
relationship: part_of UPa:UER00846 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 6/6

[Term]
id: UPa:UCR02412
name: ATP + shikimate = 3-phosphoshikimate + ADP
namespace: reaction
xref: KEGG:R02412 "KEGG reaction"
xref: METACYC:SHIKIMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13124 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00493 ! shikimate
relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate
relationship: has_output_compound UPa:UPC03175 ! 3-phosphoshikimate
relationship: part_of UPa:UER00088 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7
relationship: part_of UPa:UER00088 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7

[Term]
id: UPa:UCR02413
name: NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH
namespace: reaction
xref: KEGG:R02413 "KEGG reaction"
xref: METACYC:SHIKIMATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17740 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00493 ! shikimate
relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate
relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate
relationship: part_of UPa:UER00087 {cardinality="1", direction="RL", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7
relationship: part_of UPa:UER00087 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7

[Term]
id: UPa:UCR02422
name: H(2)O + allantoate = (S)-ureidoglycolate + urea
namespace: reaction
xref: KEGG:R02422 "KEGG reaction"
xref: METACYC:ALLANTOICASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11019 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate
relationship: has_input_compound UPa:UPC00499 ! allantoate
relationship: has_output_compound UPa:UPC00086 ! urea
relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate
relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate
relationship: part_of UPa:UER00654 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1
relationship: part_of UPa:UER00654 ! (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1

[Term]
id: UPa:UCR02423
name: H(2)O + allantoate = 2-ureidoglycine + CO(2) + NH(3)
namespace: reaction
xref: KEGG:R02423 "KEGG reaction"
xref: METACYC:ALLANTOATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13596 "Rhea reaction"
xref: RHEA:27488 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00499 ! allantoate
relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine
relationship: has_output_compound UPa:UPC02091 ! 2-ureidoglycine
relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1
relationship: part_of UPa:UER00655 ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1

[Term]
id: UPa:UCR02425
name: (S)-allantoin + H(2)O = allantoate
namespace: reaction
xref: KEGG:R02425 "KEGG reaction"
xref: METACYC:ALLANTOINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17032 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin
relationship: has_input_compound UPa:UPC02350 ! (S)-allantoin
relationship: has_output_compound UPa:UPC00499 ! allantoate
relationship: has_output_compound UPa:UPC00499 {cardinality="1"} ! allantoate
relationship: part_of UPa:UER00653 ! allantoate from (S)-allantoin: step 1/1
relationship: part_of UPa:UER00653 {cardinality="1", direction="LR", order="1"} ! allantoate from (S)-allantoin: step 1/1

[Term]
id: UPa:UCR02426
name: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O
namespace: reaction
xref: KEGG:R02426 "KEGG reaction"
xref: METACYC:CDP-GLUCOSE-46-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17156 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00501 ! CDP-glucose
relationship: has_input_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: part_of UPa:UER00512 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5
relationship: part_of UPa:UER00512 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5

[Term]
id: UPa:UCR02437
name: L-rhamnose = L-rhamnulose
namespace: reaction
xref: KEGG:R02437 "KEGG reaction"
xref: METACYC:RHAMNISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23163 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00507 {cardinality="1"} ! L-rhamnose
relationship: has_input_compound UPa:UPC00507 ! L-rhamnose
relationship: has_output_compound UPa:UPC00861 ! L-rhamnulose
relationship: has_output_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose
relationship: part_of UPa:UER00601 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 1/3
relationship: part_of UPa:UER00601 ! glycerone phosphate from L-rhamnose: step 1/3

[Term]
id: UPa:UCR02439
name: ATP + L-ribulose = ADP + L-ribulose 5-phosphate
namespace: reaction
xref: KEGG:R02439 "KEGG reaction"
xref: METACYC:RXN0-5116 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22075 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose
relationship: has_input_compound UPa:UPC00508 ! L-ribulose
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01101 ! L-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate
relationship: part_of UPa:UER00566 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3
relationship: part_of UPa:UER00566 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3

[Term]
id: UPa:UCR02466
name: 3-sulfino-L-alanine = CO(2) + hypotaurine
namespace: reaction
xref: KEGG:R02466 "KEGG reaction"
xref: METACYC:SULFINOALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16880 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine
relationship: has_input_compound UPa:UPC00606 ! 3-sulfino-L-alanine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00519 ! hypotaurine
relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine
relationship: part_of UPa:UER00538 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 2/2
relationship: part_of UPa:UER00538 ! hypotaurine from L-cysteine: step 2/2

[Term]
id: UPa:UCR02467
name: 2-aminoethanethiol + O(2) = hypotaurine
namespace: reaction
xref: KEGG:R02467 "KEGG reaction"
xref: METACYC:CYSTEAMINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14412 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC01678 {cardinality="1"} ! 2-aminoethanethiol
relationship: has_input_compound UPa:UPC01678 ! 2-aminoethanethiol
relationship: has_output_compound UPa:UPC00519 ! hypotaurine
relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine
relationship: part_of UPa:UER00536 {cardinality="1", direction="LR", order="1"} ! hypotaurine from 2-aminoethanethiol: step 1/1
relationship: part_of UPa:UER00536 ! hypotaurine from 2-aminoethanethiol: step 1/1

[Term]
id: UPa:UCR02472
name: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH
namespace: reaction
xref: KEGG:R02472 "KEGG reaction"
xref: METACYC:2-DEHYDROPANTOATE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16236 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate
relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate
relationship: has_output_compound UPa:UPC00966 ! 2-dehydropantoate
relationship: part_of UPa:UER00004 ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2
relationship: part_of UPa:UER00004 {cardinality="1", direction="RL", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2

[Term]
id: UPa:UCR02473
name: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate
namespace: reaction
xref: KEGG:R02473 "KEGG reaction"
xref: METACYC:PANTOATE-BETA-ALANINE-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10915 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00099 ! beta-alanine
relationship: has_input_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine
relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate
relationship: has_input_compound UPa:UPC00522 ! (R)-pantoate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00864 ! (R)-pantothenate
relationship: has_output_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate
relationship: part_of UPa:UER00005 ! (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1
relationship: part_of UPa:UER00005 {cardinality="1", direction="LR", order="1"} ! (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1

[Term]
id: UPa:UCR02493
name: ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate
namespace: reaction
xref: KEGG:R02493 "KEGG reaction"
xref: METACYC:PYRAMKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25107 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00534 ! pyridoxamine
relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate
relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate
relationship: part_of UPa:UER00299 {cardinality="1", direction="LR", order="1"} ! pyridoxamine 5'-phosphate from pyridoxamine: step 1/1
relationship: part_of UPa:UER00299 ! pyridoxamine 5'-phosphate from pyridoxamine: step 1/1

[Term]
id: UPa:UCR02494
name: phosphate + pyridoxamine = H(2)O + pyridoxamine 5'-phosphate
namespace: reaction
xref: KEGG:R02494 "KEGG reaction"
xref: RHEA:25138 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00534 ! pyridoxamine
relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00647 ! pyridoxamine 5'-phosphate
relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate
relationship: part_of UPa:UER00302 ! pyridoxamine from pyridoxamine 5'-phosphate: step 1/1
relationship: part_of UPa:UER00302 {cardinality="1", direction="RL", order="1"} ! pyridoxamine from pyridoxamine 5'-phosphate: step 1/1

[Term]
id: UPa:UCR02519
name: O(2) + homogentisate = 4-maleylacetoacetate
namespace: reaction
xref: KEGG:R02519 "KEGG reaction"
xref: METACYC:HOMOGENTISATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15452 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00544 ! homogentisate
relationship: has_input_compound UPa:UPC00544 {cardinality="1"} ! homogentisate
relationship: has_output_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate
relationship: has_output_compound UPa:UPC01036 ! 4-maleylacetoacetate
relationship: part_of UPa:UER00339 ! acetoacetate and fumarate from L-phenylalanine: step 4/6
relationship: part_of UPa:UER00339 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 4/6

[Term]
id: UPa:UCR02521
name: (4-hydroxyphenyl)pyruvate + O(2) = CO(2) + homogentisate
namespace: reaction
xref: KEGG:R02521 "KEGG reaction"
xref: METACYC:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16192 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate
relationship: has_input_compound UPa:UPC01179 ! (4-hydroxyphenyl)pyruvate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00544 ! homogentisate
relationship: has_output_compound UPa:UPC00544 {cardinality="1"} ! homogentisate
relationship: part_of UPa:UER00362 ! acetoacetate and fumarate from L-phenylalanine: step 3/6
relationship: part_of UPa:UER00362 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 3/6

[Term]
id: UPa:UCR02522
name: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O
namespace: reaction
xref: KEGG:R02522 "KEGG reaction"
xref: METACYC:L-ARABINONATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20971 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00545 ! L-arabinonate
relationship: has_input_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00684 ! 2-dehydro-3-deoxy-L-arabinonate
relationship: has_output_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate
relationship: part_of UPa:UER00570 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3
relationship: part_of UPa:UER00570 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3

[Term]
id: UPa:UCR02526
name: H(2)O + L-arabinono-1,4-lactone = L-arabinonate
namespace: reaction
xref: KEGG:R02526 "KEGG reaction"
xref: METACYC:L-ARABINONOLACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16220 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone
relationship: has_input_compound UPa:UPC01114 ! L-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate
relationship: has_output_compound UPa:UPC00545 ! L-arabinonate
relationship: part_of UPa:UER00569 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3
relationship: part_of UPa:UER00569 ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3

[Term]
id: UPa:UCR02530
name: (R)-S-lactoylglutathione = glutathione + methylglyoxal
namespace: reaction
xref: KEGG:R02530 "KEGG reaction"
xref: METACYC:GLYOXI-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19072 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione
relationship: has_input_compound UPa:UPC03451 ! (R)-S-lactoylglutathione
relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione
relationship: has_output_compound UPa:UPC00051 ! glutathione
relationship: has_output_compound UPa:UPC00546 {cardinality="1"} ! methylglyoxal
relationship: has_output_compound UPa:UPC00546 ! methylglyoxal
relationship: part_of UPa:UER00675 ! (R)-lactate from methylglyoxal: step 1/2
relationship: part_of UPa:UER00675 {cardinality="1", direction="RL", order="1"} ! (R)-lactate from methylglyoxal: step 1/2

[Term]
id: UPa:UCR02533
name: (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R02533 "KEGG reaction"
xref: METACYC:RXN66-241 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25272 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline
relationship: has_input_compound UPa:UPC00547 ! (R)-noradrenaline
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00788 {cardinality="1"} ! (R)-adrenaline
relationship: has_output_compound UPa:UPC00788 ! (R)-adrenaline
relationship: part_of UPa:UER00736 ! (R)-adrenaline from (R)-noradrenaline: step 1/1
relationship: part_of UPa:UER00736 {cardinality="1", direction="LR", order="1"} ! (R)-adrenaline from (R)-noradrenaline: step 1/1

[Term]
id: UPa:UCR02535
name: L-ascorbate + O(2) + dopamine = (R)-noradrenaline + H(2)O + L-dehydroascorbate
namespace: reaction
xref: KEGG:R02535 "KEGG reaction"
xref: METACYC:DOPAMINE-BETA-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19120 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate
relationship: has_input_compound UPa:UPC00072 ! L-ascorbate
relationship: has_input_compound UPa:UPC03758 ! dopamine
relationship: has_input_compound UPa:UPC03758 {cardinality="1"} ! dopamine
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00547 ! (R)-noradrenaline
relationship: has_output_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline
relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate
relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate
relationship: part_of UPa:UER00735 {cardinality="1", direction="LR", order="1"} ! (R)-noradrenaline from dopamine: step 1/1
relationship: part_of UPa:UER00735 ! (R)-noradrenaline from dopamine: step 1/1

[Term]
id: UPa:UCR02536
name: H(2)O + NAD(+) + phenylacetaldehyde = H(+) + NADH + phenylacetate
namespace: reaction
xref: KEGG:R02536 "KEGG reaction"
xref: METACYC:PHENDEHYD-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21395 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00601 ! phenylacetaldehyde
relationship: has_input_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC07086 {cardinality="1"} ! phenylacetate
relationship: has_output_compound UPa:UPC07086 ! phenylacetate
relationship: part_of UPa:UER00724 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 3/3
relationship: part_of UPa:UER00724 ! phenylacetate from L-phenylalanine: step 3/3

[Term]
id: UPa:UCR02545
name: NAD(+) + meso-tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH
namespace: reaction
xref: KEGG:R02545 "KEGG reaction"
xref: METACYC:RXN-8643 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16460 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00552 ! meso-tartrate
relationship: has_input_compound UPa:UPC00552 {cardinality="1"} ! meso-tartrate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate
relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate
relationship: part_of UPa:UER00801 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1
relationship: part_of UPa:UER00801 ! 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1

[Term]
id: UPa:UCR02549
name: 4-aminobutanal + H(2)O + NAD(+) = 4-aminobutanoate + H(+) + NADH
namespace: reaction
xref: KEGG:R02549 "KEGG reaction"
xref: METACYC:AMINOBUTDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19108 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00555 ! 4-aminobutanal
relationship: has_input_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate
relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate
relationship: part_of UPa:UER00292 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from 4-aminobutanal: step 1/1
relationship: part_of UPa:UER00292 ! 4-aminobutanoate from 4-aminobutanal: step 1/1

[Term]
id: UPa:UCR02553
name: NAD(+) + cyclopentanol = H(+) + NADH + cyclopentanone
namespace: reaction
xref: KEGG:R02553 "KEGG reaction"
xref: METACYC:CYCLOPENTANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11731 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC02020 {cardinality="1"} ! cyclopentanol
relationship: has_input_compound UPa:UPC02020 ! cyclopentanol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone
relationship: has_output_compound UPa:UPC00557 ! cyclopentanone
relationship: part_of UPa:UER00749 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 1/2
relationship: part_of UPa:UER00749 ! 5-valerolactone from cyclopentanol: step 1/2

[Term]
id: UPa:UCR02554
name: H(+) + NADPH + O(2) + cyclopentanone = 5-valerolactone + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R02554 "KEGG reaction"
xref: METACYC:CYCLOPENTANONE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15740 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone
relationship: has_input_compound UPa:UPC00557 ! cyclopentanone
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC02240 {cardinality="1"} ! 5-valerolactone
relationship: has_output_compound UPa:UPC02240 ! 5-valerolactone
relationship: part_of UPa:UER00750 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 2/2
relationship: part_of UPa:UER00750 ! 5-valerolactone from cyclopentanol: step 2/2

[Term]
id: UPa:UCR02565
name: H(2)O + NAD(+) + betaine aldehyde = 2 H(+) + NADH + betaine
namespace: reaction
xref: KEGG:R02565 "KEGG reaction"
xref: METACYC:BADH-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15308 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00576 ! betaine aldehyde
relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00719 ! betaine
relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine
relationship: part_of UPa:UER00386 {cardinality="1", direction="LR", order="1"} ! betaine from betaine aldehyde: step 1/1
relationship: part_of UPa:UER00386 ! betaine from betaine aldehyde: step 1/1

[Term]
id: UPa:UCR02571
name: Enzyme N6-(dihydrolipoyl)lysine + glutaryl-CoA = CoA + S(8)-glutaryldihydrolipoamide
namespace: reaction
xref: KEGG:R02571 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00527 {cardinality="1"} ! glutaryl-CoA
relationship: has_input_compound UPa:UPC00527 ! glutaryl-CoA
relationship: has_input_compound UPa:UPC15973 {cardinality="1"} ! Enzyme N6-(dihydrolipoyl)lysine
relationship: has_input_compound UPa:UPC15973 ! Enzyme N6-(dihydrolipoyl)lysine
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC06157 ! S(8)-glutaryldihydrolipoamide
relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide
relationship: part_of UPa:UER00840 ! glutaryl-CoA from L-lysine: step 6/6
relationship: part_of UPa:UER00840 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 6/6

[Term]
id: UPa:UCR02601
name: 2-hydroxy-2,4-pentadienoate + H(2)O = 4-hydroxy-2-oxopentanoate
namespace: reaction
xref: KEGG:R02601 "KEGG reaction"
xref: METACYC:2-OXOPENT-4-ENOATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22583 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate
relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC03589 ! 4-hydroxy-2-oxopentanoate
relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate
relationship: part_of UPa:UER00796 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4
relationship: part_of UPa:UER00796 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4
relationship: part_of UPa:UER00906 ! acetaldehyde and pyruvate from p-cumate: step 6/7
relationship: part_of UPa:UER00906 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 6/7

[Term]
id: UPa:UCR02603
name: 2-hydroxy-2,4-pentadienoate + succinate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O
namespace: reaction
xref: KEGG:R02603 "KEGG reaction"
xref: METACYC:MHPCHYDROL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24792 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00042 ! succinate
relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate
relationship: has_input_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate
relationship: has_output_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate
relationship: part_of UPa:UER00795 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4
relationship: part_of UPa:UER00795 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4

[Term]
id: UPa:UCR02606
name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(2)O = 2-hydroxy-2,4-pentadienoate + benzoate
namespace: reaction
xref: KEGG:R02606 "KEGG reaction"
xref: METACYC:3.7.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17164 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
relationship: has_input_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
relationship: has_output_compound UPa:UPC00180 ! benzoate
relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate
relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate
relationship: part_of UPa:UER00253 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4
relationship: part_of UPa:UER00253 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4

[Term]
id: UPa:UCR02613
name: 2-phenylethylamine + H(2)O + O(2) = H(2)O(2) + NH(3) + phenylacetaldehyde
namespace: reaction
xref: KEGG:R02613 "KEGG reaction"
xref: METACYC:AMINEPHEN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25268 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine
relationship: has_input_compound UPa:UPC05332 ! 2-phenylethylamine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde
relationship: has_output_compound UPa:UPC00601 ! phenylacetaldehyde
relationship: part_of UPa:UER00723 ! phenylacetate from L-phenylalanine: step 2/3
relationship: part_of UPa:UER00723 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 2/3

[Term]
id: UPa:UCR02649
name: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate
namespace: reaction
xref: KEGG:R02649 "KEGG reaction"
xref: METACYC:ACETYLGLUTKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14632 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate
relationship: has_input_compound UPa:UPC00624 ! N-acetyl-L-glutamate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate
relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate
relationship: part_of UPa:UER00107 ! N(2)-acetyl-L-ornithine from L-glutamate: step 2/4
relationship: part_of UPa:UER00107 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 2/4

[Term]
id: UPa:UCR02664
name: 2-phospho-D-glycerate + ATP = 2,3-bisphospho-D-glycerate + ADP
namespace: reaction
xref: KEGG:R02664 "KEGG reaction"
xref: RHEA:42411 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00631 ! 2-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate
relationship: has_output_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate
relationship: part_of UPa:UER00609 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2
relationship: part_of UPa:UER00609 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2

[Term]
id: UPa:UCR02665
name: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde
namespace: reaction
xref: KEGG:R02665 "KEGG reaction"
xref: METACYC:1.13.11.6-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17956 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate
relationship: has_input_compound UPa:UPC00632 ! 3-hydroxyanthranilate
relationship: has_output_compound UPa:UPC04409 ! 2-amino-3-carboxymuconate semialdehyde
relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde
relationship: part_of UPa:UER00330 ! quinolinate from L-kynurenine: step 3/3
relationship: part_of UPa:UER00330 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 3/3

[Term]
id: UPa:UCR02668
name: 3-hydroxy-L-kynurenine + H(2)O = 3-hydroxyanthranilate + L-alanine
namespace: reaction
xref: KEGG:R02668 "KEGG reaction"
xref: METACYC:3-HYDROXY-KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25146 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03227 ! 3-hydroxy-L-kynurenine
relationship: has_input_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine
relationship: has_output_compound UPa:UPC00041 ! L-alanine
relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate
relationship: has_output_compound UPa:UPC00632 ! 3-hydroxyanthranilate
relationship: part_of UPa:UER00329 ! quinolinate from L-kynurenine: step 2/3
relationship: part_of UPa:UER00329 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 2/3

[Term]
id: UPa:UCR02698
name: 4-hydroxyphenylacetate + H(+) + NADH + O(2) = (3,4-dihydroxyphenyl)acetate + H(2)O + NAD(+)
namespace: reaction
xref: KEGG:R02698 "KEGG reaction"
xref: RHEA:16684 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00642 {cardinality="1"} ! 4-hydroxyphenylacetate
relationship: has_input_compound UPa:UPC00642 ! 4-hydroxyphenylacetate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate
relationship: has_output_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate
relationship: part_of UPa:UER00416 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7
relationship: part_of UPa:UER00416 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7

[Term]
id: UPa:UCR02701
name: 5-hydroxy-L-tryptophan = CO(2) + serotonin
namespace: reaction
xref: KEGG:R02701 "KEGG reaction"
xref: METACYC:RXN3DJ-170 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18536 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan
relationship: has_input_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00780 {cardinality="1"} ! serotonin
relationship: has_output_compound UPa:UPC00780 ! serotonin
relationship: part_of UPa:UER00814 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 2/2
relationship: part_of UPa:UER00814 ! serotonin from L-tryptophan: step 2/2

[Term]
id: UPa:UCR02705
name: ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate
namespace: reaction
xref: KEGG:R02705 "KEGG reaction"
xref: METACYC:NANK-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25256 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine
relationship: has_input_compound UPa:UPC00645 ! N-acetyl-D-mannosamine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate
relationship: has_output_compound UPa:UPC04257 ! N-acetyl-D-mannosamine 6-phosphate
relationship: part_of UPa:UER00681 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 2/5
relationship: part_of UPa:UER00681 ! D-fructose 6-phosphate from N-acetylneuraminate: step 2/5

[Term]
id: UPa:UCR02715
name: D-arabinono-1,4-lactone + O(2) = H(2)O(2) + dehydro-D-arabinono-1,4-lactone
namespace: reaction
xref: KEGG:R02715 "KEGG reaction"
xref: METACYC:1.1.3.37-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23759 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone
relationship: has_input_compound UPa:UPC00652 ! D-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC06316 {cardinality="1"} ! dehydro-D-arabinono-1,4-lactone
relationship: has_output_compound UPa:UPC06316 ! dehydro-D-arabinono-1,4-lactone
relationship: part_of UPa:UER00766 {cardinality="1", direction="LR", order="1"} ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2
relationship: part_of UPa:UER00766 ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2

[Term]
id: UPa:UCR02733
name: H(2)O + N-acetyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + acetate
namespace: reaction
xref: KEGG:R02733 "KEGG reaction"
xref: METACYC:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20408 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate
relationship: part_of UPa:UER00024 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3
relationship: part_of UPa:UER00024 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3

[Term]
id: UPa:UCR02734
name: H(2)O + N-succinyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + succinate
namespace: reaction
xref: KEGG:R02734 "KEGG reaction"
xref: METACYC:SUCCDIAMINOPIMDESUCC-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22611 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00666 ! LL-2,6-diaminopimelate
relationship: part_of UPa:UER00021 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3
relationship: part_of UPa:UER00021 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3

[Term]
id: UPa:UCR02735
name: LL-2,6-diaminopimelate = DL-2,6-diaminopimelate
namespace: reaction
xref: KEGG:R02735 "KEGG reaction"
xref: METACYC:DIAMINOPIMEPIM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15396 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC00666 ! LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00680 ! DL-2,6-diaminopimelate
relationship: part_of UPa:UER00025 {cardinality="1", direction="LR", order="1"} ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1
relationship: part_of UPa:UER00025 ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1

[Term]
id: UPa:UCR02749
name: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate
namespace: reaction
xref: KEGG:R02749 "KEGG reaction"
xref: METACYC:D-PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25208 "Rhea reaction"
xref: RHEA:27661 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate
relationship: has_input_compound UPa:UPC00672 ! 2-deoxy-alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC00673 ! 2-deoxy-D-ribose 5-phosphate
relationship: has_output_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate
relationship: part_of UPa:UER00467 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2
relationship: part_of UPa:UER00467 ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2

[Term]
id: UPa:UCR02752
name: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O
namespace: reaction
xref: KEGG:R02752 "KEGG reaction"
xref: METACYC:GLUCARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14576 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00818 ! D-glucarate
relationship: has_input_compound UPa:UPC00818 {cardinality="1"} ! D-glucarate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate
relationship: part_of UPa:UER00627 ! 2,5-dioxopentanoate from D-glucarate: step 1/2
relationship: part_of UPa:UER00627 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 1/2

[Term]
id: UPa:UCR02754
name: 5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate
namespace: reaction
xref: KEGG:R02754 "KEGG reaction"
xref: METACYC:KDGALDOL-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:27729 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC01146 ! 2-hydroxy-3-oxopropanoate
relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate
relationship: part_of UPa:UER00630 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 2/3
relationship: part_of UPa:UER00630 ! D-glycerate from galactarate: step 2/3

[Term]
id: UPa:UCR02755
name: DL-2,6-diaminopimelate + H(2)O + NADP(+) = (S)-2-amino-6-oxopimelate + H(+) + NADPH + NH(3)
namespace: reaction
xref: KEGG:R02755 "KEGG reaction"
xref: METACYC:DIAMINOPIMELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13564 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00680 ! DL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate
relationship: has_output_compound UPa:UPC03871 ! (S)-2-amino-6-oxopimelate
relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="2"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1
relationship: part_of UPa:UER00026 ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1

[Term]
id: UPa:UCR02765
name: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
namespace: reaction
xref: KEGG:R02765 "KEGG reaction"
xref: METACYC:METHYLMALONYL-COA-EPIM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20556 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01213 ! (R)-methylmalonyl-CoA
relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA
relationship: has_output_compound UPa:UPC00683 ! (S)-methylmalonyl-CoA
relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA
relationship: part_of UPa:UER00909 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from propanoyl-CoA: step 2/3
relationship: part_of UPa:UER00909 ! succinyl-CoA from propanoyl-CoA: step 2/3

[Term]
id: UPa:UCR02782
name: scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O
namespace: reaction
xref: KEGG:R02782 "KEGG reaction"
xref: METACYC:MYO-INOSOSE-2-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14068 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose
relationship: has_input_compound UPa:UPC00691 ! scyllo-inosose
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC04287 ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione
relationship: has_output_compound UPa:UPC04287 {cardinality="1"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione
relationship: part_of UPa:UER00144 ! acetyl-CoA from myo-inositol: step 2/7
relationship: part_of UPa:UER00144 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 2/7

[Term]
id: UPa:UCR02804
name: H(2)O + dinitrogen + 2 ferricytochrome c = 2 H(+) + 2 ferrocytochrome c + nitrous oxide
namespace: reaction
xref: KEGG:R02804 "KEGG reaction"
xref: METACYC:RXN-12130 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15496 "Rhea reaction"
xref: RHEA:43111 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c
relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c
relationship: has_input_compound UPa:UPC00697 ! dinitrogen
relationship: has_input_compound UPa:UPC00697 {cardinality="1"} ! dinitrogen
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c
relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c
relationship: has_output_compound UPa:UPC00887 ! nitrous oxide
relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide
relationship: part_of UPa:UER00709 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 4/4
relationship: part_of UPa:UER00709 ! dinitrogen from nitrate: step 4/4

[Term]
id: UPa:UCR02821
name: L-homocysteine + betaine = L-methionine + N,N-dimethylglycine
namespace: reaction
xref: KEGG:R02821 "KEGG reaction"
xref: METACYC:2.1.1.5-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22339 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: has_input_compound UPa:UPC00155 ! L-homocysteine
relationship: has_input_compound UPa:UPC00719 ! betaine
relationship: has_input_compound UPa:UPC00719 {cardinality="1"} ! betaine
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine
relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine
relationship: part_of UPa:UER00083 ! L-methionine from L-homocysteine (BhmT route): step 1/1
relationship: part_of UPa:UER00083 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (BhmT route): step 1/1
relationship: part_of UPa:UER00432 ! sarcosine from betaine: step 1/2
relationship: part_of UPa:UER00432 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 1/2

[Term]
id: UPa:UCR02860
name: H(2)O + acceptor + nicotine = (S)-6-hydroxynicotine + reduced acceptor
namespace: reaction
xref: KEGG:R02860 "KEGG reaction"
xref: METACYC:NICOTINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14772 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine
relationship: has_input_compound UPa:UPC16150 ! nicotine
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC01056 ! (S)-6-hydroxynicotine
relationship: has_output_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine
relationship: part_of UPa:UER00487 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2
relationship: part_of UPa:UER00487 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2

[Term]
id: UPa:UCR02864
name: 2 H(+) + siroheme = Fe2+ + sirohydrochlorin
namespace: reaction
xref: KEGG:R02864 "KEGG reaction"
xref: METACYC:SIROHEME-FERROCHELAT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24363 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00748 ! siroheme
relationship: has_input_compound UPa:UPC00748 {cardinality="1"} ! siroheme
relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin
relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin
relationship: has_output_compound UPa:UPC14818 ! Fe2+
relationship: has_output_compound UPa:UPC14818 {cardinality="1"} ! Fe2+
relationship: part_of UPa:UER00376 {cardinality="1", direction="RL", order="1"} ! siroheme from sirohydrochlorin: step 1/1
relationship: part_of UPa:UER00376 ! siroheme from sirohydrochlorin: step 1/1

[Term]
id: UPa:UCR02869
name: S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine + spermine
namespace: reaction
xref: KEGG:R02869 "KEGG reaction"
xref: METACYC:SPERMINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19976 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine
relationship: has_input_compound UPa:UPC00315 ! spermidine
relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine
relationship: has_input_compound UPa:UPC01137 ! S-adenosylmethioninamine
relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00170 ! S-methyl-5'-thioadenosine
relationship: has_output_compound UPa:UPC00750 {cardinality="1"} ! spermine
relationship: has_output_compound UPa:UPC00750 ! spermine
relationship: part_of UPa:UER00315 ! spermine from spermidine: step 1/1
relationship: part_of UPa:UER00315 {cardinality="1", direction="LR", order="1"} ! spermine from spermidine: step 1/1

[Term]
id: UPa:UCR02874
name: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R02874 "KEGG reaction"
xref: METACYC:SQUALENE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25285 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00751 {cardinality="1"} ! squalene
relationship: has_input_compound UPa:UPC00751 ! squalene
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene
relationship: has_output_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene
relationship: part_of UPa:UER00752 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 2/3
relationship: part_of UPa:UER00752 ! lanosterol from farnesyl diphosphate: step 2/3

[Term]
id: UPa:UCR02911
name: acetyl-CoA + serotonin = CoA + N-acetylserotonin
namespace: reaction
xref: KEGG:R02911 "KEGG reaction"
xref: METACYC:RXN3DJ-35528 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25220 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00780 ! serotonin
relationship: has_input_compound UPa:UPC00780 {cardinality="1"} ! serotonin
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00978 ! N-acetylserotonin
relationship: has_output_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin
relationship: part_of UPa:UER00815 ! melatonin from serotonin: step 1/2
relationship: part_of UPa:UER00815 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 1/2

[Term]
id: UPa:UCR02914
name: 4-imidazolone-5-propanoate = H(2)O + trans-urocanate
namespace: reaction
xref: KEGG:R02914 "KEGG reaction"
xref: METACYC:UROCANATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13104 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03680 ! 4-imidazolone-5-propanoate
relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate
relationship: has_output_compound UPa:UPC00785 ! trans-urocanate
relationship: part_of UPa:UER00550 {cardinality="1", direction="RL", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 2/3
relationship: part_of UPa:UER00550 ! N-formimidoyl-L-glutamate from L-histidine: step 2/3

[Term]
id: UPa:UCR02922
name: H(2)O + creatinine = N-methylhydantoin + NH(3)
namespace: reaction
xref: KEGG:R02922 "KEGG reaction"
xref: METACYC:CREATININE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12684 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00791 {cardinality="1"} ! creatinine
relationship: has_input_compound UPa:UPC00791 ! creatinine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC02565 ! N-methylhydantoin
relationship: has_output_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin
relationship: part_of UPa:UER00395 ! sarcosine from creatinine: step 1/3
relationship: part_of UPa:UER00395 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 1/3

[Term]
id: UPa:UCR02933
name: H(2)O + L-gulono-1,4-lactone = L-gulonate
namespace: reaction
xref: KEGG:R02933 "KEGG reaction"
xref: METACYC:RXN-8783 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42519 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC01040 ! L-gulono-1,4-lactone
relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone
relationship: has_output_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate
relationship: has_output_compound UPa:UPC00800 ! L-gulonate
relationship: part_of UPa:UER00938 ! L-ascorbate from UDP-alpha-D-glucuronate: step 3/4
relationship: part_of UPa:UER00938 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 3/4

[Term]
id: UPa:UCR02935
name: (S)-ureidoglycolate + NAD(+) = H(+) + NADH + oxalurate
namespace: reaction
xref: KEGG:R02935 "KEGG reaction"
xref: RHEA:15332 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate
relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate
relationship: has_output_compound UPa:UPC00802 ! oxalurate
relationship: part_of UPa:UER00975 ! None
relationship: part_of UPa:UER00975 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR02936
name: (S)-ureidoglycolate + NADP(+) = H(+) + NADPH + oxalurate
namespace: reaction
xref: KEGG:R02936 "KEGG reaction"
xref: METACYC:R165-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15336 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate
relationship: has_input_compound UPa:UPC00603 ! (S)-ureidoglycolate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate
relationship: has_output_compound UPa:UPC00802 ! oxalurate
relationship: part_of UPa:UER00976 ! None
relationship: part_of UPa:UER00976 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR02946
name: (R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH
namespace: reaction
xref: KEGG:R02946 "KEGG reaction"
xref: METACYC:RR-BUTANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24343 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC03044 {cardinality="1"} ! (R,R)-butane-2,3-diol
relationship: has_input_compound UPa:UPC03044 ! (R,R)-butane-2,3-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00810 ! (R)-acetoin
relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin
relationship: part_of UPa:UER00679 ! (R,R)-butane-2,3-diol from pyruvate: step 3/3
relationship: part_of UPa:UER00679 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 3/3

[Term]
id: UPa:UCR02948
name: (S)-2-acetolactate = (R)-acetoin + CO(2)
namespace: reaction
xref: KEGG:R02948 "KEGG reaction"
xref: METACYC:ACETOLACTATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21583 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate
relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00810 ! (R)-acetoin
relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin
relationship: part_of UPa:UER00678 ! (R,R)-butane-2,3-diol from pyruvate: step 2/3
relationship: part_of UPa:UER00678 {cardinality="1", direction="LR", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 2/3

[Term]
id: UPa:UCR02988
name: 3-oxoadipate + NAD(+) = H(+) + NADH + maleylacetate
namespace: reaction
xref: KEGG:R02988 "KEGG reaction"
xref: RHEA:16984 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate
relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC02222 ! maleylacetate
relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate
relationship: part_of UPa:UER00957 {cardinality="1", direction="RL", order="1"} ! None
relationship: part_of UPa:UER00957 ! None

[Term]
id: UPa:UCR02989
name: 3-oxoadipate + NADP(+) = H(+) + NADPH + maleylacetate
namespace: reaction
xref: KEGG:R02989 "KEGG reaction"
xref: METACYC:MALEYLACETATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16988 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate
relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC02222 ! maleylacetate
relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate
relationship: part_of UPa:UER00958 {cardinality="1", direction="RL", order="1"} ! None
relationship: part_of UPa:UER00958 ! None

[Term]
id: UPa:UCR02990
name: 3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate
namespace: reaction
xref: KEGG:R02990 "KEGG reaction"
xref: METACYC:3-OXOADIPATE-COA-TRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12051 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_input_compound UPa:UPC00846 ! 3-oxoadipate
relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA
relationship: has_output_compound UPa:UPC02232 ! 3-oxoadipyl-CoA
relationship: part_of UPa:UER00262 ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2
relationship: part_of UPa:UER00262 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2

[Term]
id: UPa:UCR02991
name: 5-oxo-4,5-dihydro-2-furylacetate + H(2)O = 3-oxoadipate
namespace: reaction
xref: KEGG:R02991 "KEGG reaction"
xref: METACYC:3-OXOADIPATE-ENOL-LACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10187 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: has_input_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: has_output_compound UPa:UPC00846 ! 3-oxoadipate
relationship: has_output_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate
relationship: part_of UPa:UER00261 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1
relationship: part_of UPa:UER00261 ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1

[Term]
id: UPa:UCR02992
name: 4-pyridoxolactone + H(2)O = 4-pyridoxate
namespace: reaction
xref: KEGG:R02992 "KEGG reaction"
xref: METACYC:4-PYRIDOXOLACTONASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14304 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone
relationship: has_input_compound UPa:UPC00971 ! 4-pyridoxolactone
relationship: has_output_compound UPa:UPC00847 {cardinality="1"} ! 4-pyridoxate
relationship: has_output_compound UPa:UPC00847 ! 4-pyridoxate
relationship: part_of UPa:UER00589 ! 4-pyridoxate from pyridoxal: step 2/2
relationship: part_of UPa:UER00589 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 2/2

[Term]
id: UPa:UCR03005
name: ATP + nicotinate D-ribonucleotide = deamido-NAD(+) + diphosphate
namespace: reaction
xref: KEGG:R03005 "KEGG reaction"
xref: METACYC:NICONUCADENYLYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22863 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide
relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+)
relationship: has_output_compound UPa:UPC00857 ! deamido-NAD(+)
relationship: part_of UPa:UER00332 ! deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1
relationship: part_of UPa:UER00332 {cardinality="1", direction="LR", order="1"} ! deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1

[Term]
id: UPa:UCR03013
name: H(2)O + L-histidinol phosphate = L-histidinol + phosphate
namespace: reaction
xref: KEGG:R03013 "KEGG reaction"
xref: METACYC:HISTIDPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14468 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate
relationship: has_input_compound UPa:UPC01100 ! L-histidinol phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol
relationship: has_output_compound UPa:UPC00860 ! L-histidinol
relationship: part_of UPa:UER00013 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9
relationship: part_of UPa:UER00013 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9

[Term]
id: UPa:UCR03014
name: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate
namespace: reaction
xref: KEGG:R03014 "KEGG reaction"
xref: METACYC:RHAMNULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20120 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose
relationship: has_input_compound UPa:UPC00861 ! L-rhamnulose
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate
relationship: has_output_compound UPa:UPC01131 ! L-rhamnulose 1-phosphate
relationship: part_of UPa:UER00602 ! glycerone phosphate from L-rhamnose: step 2/3
relationship: part_of UPa:UER00602 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 2/3

[Term]
id: UPa:UCR03015
name: H(2)O + N-formylmethanofuran + acceptor = CO(2) + methanofuran + reduced acceptor
namespace: reaction
xref: KEGG:R03015 "KEGG reaction"
xref: METACYC:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19844 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran
relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran
relationship: has_output_compound UPa:UPC00862 ! methanofuran
relationship: part_of UPa:UER00692 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3
relationship: part_of UPa:UER00692 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3

[Term]
id: UPa:UCR03018
name: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP
namespace: reaction
xref: KEGG:R03018 "KEGG reaction"
xref: METACYC:PANTOTHENATE-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16376 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate
relationship: has_input_compound UPa:UPC00864 ! (R)-pantothenate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate
relationship: has_output_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate
relationship: part_of UPa:UER00352 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 1/5
relationship: part_of UPa:UER00352 ! CoA from (R)-pantothenate: step 1/5

[Term]
id: UPa:UCR03028
name: glutaconyl-1-CoA = CO(2) + crotonoyl-CoA
namespace: reaction
xref: KEGG:R03028 "KEGG reaction"
xref: METACYC:GLUTACONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23975 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA
relationship: has_input_compound UPa:UPC02411 ! glutaconyl-1-CoA
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00877 ! crotonoyl-CoA
relationship: has_output_compound UPa:UPC00877 {cardinality="1"} ! crotonoyl-CoA
relationship: part_of UPa:UER00688 ! crotonoyl-CoA from L-glutamate: step 5/5
relationship: part_of UPa:UER00688 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 5/5

[Term]
id: UPa:UCR03033
name: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O
namespace: reaction
xref: KEGG:R03033 "KEGG reaction"
xref: METACYC:GALACTONDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18652 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00880 {cardinality="1"} ! D-galactonate
relationship: has_input_compound UPa:UPC00880 ! D-galactonate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate
relationship: has_output_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate
relationship: part_of UPa:UER00518 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3
relationship: part_of UPa:UER00518 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3

[Term]
id: UPa:UCR03035
name: ATP + pantotheine 4'-phosphate = 3'-dephospho-CoA + diphosphate
namespace: reaction
xref: KEGG:R03035 "KEGG reaction"
xref: METACYC:PANTEPADENYLYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19804 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC01134 ! pantotheine 4'-phosphate
relationship: has_input_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA
relationship: has_output_compound UPa:UPC00882 ! 3'-dephospho-CoA
relationship: part_of UPa:UER00355 ! CoA from (R)-pantothenate: step 4/5
relationship: part_of UPa:UER00355 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 4/5

[Term]
id: UPa:UCR03067
name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
namespace: reaction
xref: KEGG:R03067 "KEGG reaction"
xref: METACYC:H2PTEROATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19952 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate
relationship: has_input_compound UPa:UPC00568 ! 4-aminobenzoate
relationship: has_input_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
relationship: has_input_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate
relationship: has_output_compound UPa:UPC00921 ! 7,8-dihydropteroate
relationship: part_of UPa:UER00156 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2
relationship: part_of UPa:UER00156 ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2

[Term]
id: UPa:UCR03069
name: H(2)O + dimethylmaleate = (2R,3S)-2,3-dimethylmalate
namespace: reaction
xref: KEGG:R03069 "KEGG reaction"
xref: METACYC:DIMETHYLMALEATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20256 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00922 ! dimethylmaleate
relationship: has_input_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate
relationship: has_output_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate
relationship: has_output_compound UPa:UPC03652 ! (2R,3S)-2,3-dimethylmalate
relationship: part_of UPa:UER01018 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 7/8
relationship: part_of UPa:UER01018 ! propanoate and pyruvate from 6-hydroxynicotinate: step 7/8

[Term]
id: UPa:UCR03070
name: 2-methylene-3-methylsuccinate = dimethylmaleate
namespace: reaction
xref: KEGG:R03070 "KEGG reaction"
xref: METACYC:METHYLITACONATE-DELTA-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23483 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate
relationship: has_input_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate
relationship: has_output_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate
relationship: has_output_compound UPa:UPC00922 ! dimethylmaleate
relationship: part_of UPa:UER01017 ! propanoate and pyruvate from 6-hydroxynicotinate: step 6/8
relationship: part_of UPa:UER01017 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 6/8

[Term]
id: UPa:UCR03083
name: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
namespace: reaction
xref: KEGG:R03083 "KEGG reaction"
xref: METACYC:3-DEHYDROQUINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21971 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04691 ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
relationship: has_input_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate
relationship: has_output_compound UPa:UPC00944 ! 3-dehydroquinate
relationship: part_of UPa:UER00085 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7
relationship: part_of UPa:UER00085 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7

[Term]
id: UPa:UCR03084
name: 3-dehydroquinate = 3-dehydroshikimate + H(2)O
namespace: reaction
xref: KEGG:R03084 "KEGG reaction"
xref: METACYC:3-DEHYDROQUINATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21099 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00944 ! 3-dehydroquinate
relationship: has_input_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC02637 ! 3-dehydroshikimate
relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate
relationship: part_of UPa:UER00086 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7
relationship: part_of UPa:UER00086 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7
relationship: part_of UPa:UER00178 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2
relationship: part_of UPa:UER00178 ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2

[Term]
id: UPa:UCR03098
name: ATP + L-alpha-aminoadipate = alpha-aminoadipoyl-C6-AMP + diphosphate
namespace: reaction
xref: KEGG:R03098 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP
relationship: has_output_compound UPa:UPC05560 ! alpha-aminoadipoyl-C6-AMP
relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3
relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3

[Term]
id: UPa:UCR03102
name: H(2)O + L-2-aminoadipate 6-semialdahyde + NAD(+) = H(+) + L-alpha-aminoadipate + NADH
namespace: reaction
xref: KEGG:R03102 "KEGG reaction"
xref: METACYC:ALLYSINE-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12311 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde
relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: part_of UPa:UER00985 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00985 ! None

[Term]
id: UPa:UCR03103
name: H(2)O + L-2-aminoadipate 6-semialdahyde + NADP(+) = H(+) + L-alpha-aminoadipate + NADPH
namespace: reaction
xref: KEGG:R03103 "KEGG reaction"
xref: METACYC:1.2.1.31-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12307 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde
relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: part_of UPa:UER00986 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00986 ! None

[Term]
id: UPa:UCR03119
name: NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH
namespace: reaction
xref: KEGG:R03119 "KEGG reaction"
xref: METACYC:13-PROPANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23191 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC02457 ! propane-1,3-diol
relationship: has_input_compound UPa:UPC02457 {cardinality="1"} ! propane-1,3-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00969 ! 3-hydroxypropanal
relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal
relationship: part_of UPa:UER00671 ! propane-1,3-diol from glycerol (reductive route): step 2/2
relationship: part_of UPa:UER00671 {cardinality="1", direction="RL", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 2/2

[Term]
id: UPa:UCR03130
name: N-acetylserotonin + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + melatonin
namespace: reaction
xref: KEGG:R03130 "KEGG reaction"
xref: METACYC:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15576 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin
relationship: has_input_compound UPa:UPC00978 ! N-acetylserotonin
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC01598 {cardinality="1"} ! melatonin
relationship: has_output_compound UPa:UPC01598 ! melatonin
relationship: part_of UPa:UER00816 ! melatonin from serotonin: step 2/2
relationship: part_of UPa:UER00816 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 2/2

[Term]
id: UPa:UCR03163
name: L-fucose = L-fuculose
namespace: reaction
xref: KEGG:R03163 "KEGG reaction"
xref: METACYC:FUCISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17236 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01019 ! L-fucose
relationship: has_input_compound UPa:UPC01019 {cardinality="1"} ! L-fucose
relationship: has_output_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose
relationship: has_output_compound UPa:UPC01721 ! L-fuculose
relationship: part_of UPa:UER00624 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3
relationship: part_of UPa:UER00624 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3

[Term]
id: UPa:UCR03164
name: 6-hydroxynicotinate + reduced ferredoxin = 6-hydroxynicotinate + oxidized ferredoxin
namespace: reaction
xref: KEGG:R03164 "KEGG reaction"
xref: METACYC:6-HYDROXYNICOTINATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17228 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin
relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin
relationship: has_input_compound UPa:UPC01020 ! 6-hydroxynicotinate
relationship: has_input_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate
relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC04226 {cardinality="1"} ! 6-hydroxynicotinate
relationship: has_output_compound UPa:UPC04226 ! 6-hydroxynicotinate
relationship: part_of UPa:UER01012 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 1/8
relationship: part_of UPa:UER01012 ! propanoate and pyruvate from 6-hydroxynicotinate: step 1/8

[Term]
id: UPa:UCR03165
name: hydroxymethylbilane = H(2)O + uroporphyrinogen III
namespace: reaction
xref: KEGG:R03165 "KEGG reaction"
xref: METACYC:UROGENIIISYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18968 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01024 ! hydroxymethylbilane
relationship: has_input_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III
relationship: has_output_compound UPa:UPC01051 ! uroporphyrinogen III
relationship: part_of UPa:UER00320 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 3/4
relationship: part_of UPa:UER00320 ! coproporphyrinogen-III from 5-aminolevulinate: step 3/4

[Term]
id: UPa:UCR03181
name: 4-maleylacetoacetate = 4-fumarylacetoacetate
namespace: reaction
xref: KEGG:R03181 "KEGG reaction"
xref: METACYC:MALEYLACETOACETATE-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14820 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01036 ! 4-maleylacetoacetate
relationship: has_input_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate
relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate
relationship: has_output_compound UPa:UPC01061 ! 4-fumarylacetoacetate
relationship: part_of UPa:UER00340 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 5/6
relationship: part_of UPa:UER00340 ! acetoacetate and fumarate from L-phenylalanine: step 5/6

[Term]
id: UPa:UCR03182
name: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + phosphate
namespace: reaction
xref: KEGG:R03182 "KEGG reaction"
xref: METACYC:DETHIOBIOTIN-SYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15808 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC01037 ! 7,8-diaminononanoate
relationship: has_input_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin
relationship: has_output_compound UPa:UPC01909 ! dethiobiotin
relationship: part_of UPa:UER00161 ! biotin from 7,8-diaminononanoate: step 1/2
relationship: part_of UPa:UER00161 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 1/2

[Term]
id: UPa:UCR03184
name: L-gulono-1,4-lactone + O(2) = H(2)O(2) + L-xylo-hexulonolactone
namespace: reaction
xref: KEGG:R03184 "KEGG reaction"
xref: METACYC:L-GULONOLACTONE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12355 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC01040 ! L-gulono-1,4-lactone
relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone
relationship: has_output_compound UPa:UPC03289 ! L-xylo-hexulonolactone
relationship: part_of UPa:UER00939 ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4
relationship: part_of UPa:UER00939 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4

[Term]
id: UPa:UCR03187
name: ATP + 2 H(2)O + N-methylhydantoin = ADP + N-carbamoylsarcosine + phosphate
namespace: reaction
xref: KEGG:R03187 "KEGG reaction"
xref: METACYC:3.5.2.14-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11723 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin
relationship: has_input_compound UPa:UPC02565 ! N-methylhydantoin
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine
relationship: has_output_compound UPa:UPC01043 ! N-carbamoylsarcosine
relationship: part_of UPa:UER00396 ! sarcosine from creatinine: step 2/3
relationship: part_of UPa:UER00396 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 2/3

[Term]
id: UPa:UCR03194
name: 2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2
namespace: reaction
xref: KEGG:R03194 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III
relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2
relationship: has_output_compound UPa:UPC02463 ! precorrin-2
relationship: part_of UPa:UER00211 {cardinality="1", direction="LR", order="1"} ! precorrin-2 from uroporphyrinogen III: step 1/1
relationship: part_of UPa:UER00211 ! precorrin-2 from uroporphyrinogen III: step 1/1

[Term]
id: UPa:UCR03197
name: uroporphyrinogen III = 4 CO(2) + coproporphyrinogen-III
namespace: reaction
xref: KEGG:R03197 "KEGG reaction"
xref: METACYC:UROGENDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19868 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01051 ! uroporphyrinogen III
relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC03263 ! coproporphyrinogen-III
relationship: has_output_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III
relationship: part_of UPa:UER00321 ! coproporphyrinogen-III from 5-aminolevulinate: step 4/4
relationship: part_of UPa:UER00321 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 4/4

[Term]
id: UPa:UCR03199
name: (S)-2,3-epoxysqualene = lanosterol
namespace: reaction
xref: KEGG:R03199 "KEGG reaction"
xref: METACYC:LANOSTEROL-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14624 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01054 ! (S)-2,3-epoxysqualene
relationship: has_input_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene
relationship: has_output_compound UPa:UPC01724 ! lanosterol
relationship: has_output_compound UPa:UPC01724 {cardinality="1"} ! lanosterol
relationship: part_of UPa:UER00753 ! lanosterol from farnesyl diphosphate: step 3/3
relationship: part_of UPa:UER00753 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 3/3

[Term]
id: UPa:UCR03202
name: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)
namespace: reaction
xref: KEGG:R03202 "KEGG reaction"
xref: METACYC:S-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11883 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine
relationship: has_input_compound UPa:UPC01056 ! (S)-6-hydroxynicotine
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine
relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine
relationship: part_of UPa:UER00919 ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2
relationship: part_of UPa:UER00919 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2

[Term]
id: UPa:UCR03209
name: ATP + CoA + pimelate = AMP + diphosphate + pimeloyl-CoA
namespace: reaction
xref: KEGG:R03209 "KEGG reaction"
xref: METACYC:6-CARBOXYHEXANOATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14784 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC02656 {cardinality="1"} ! pimelate
relationship: has_input_compound UPa:UPC02656 ! pimelate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC01063 ! pimeloyl-CoA
relationship: has_output_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA
relationship: part_of UPa:UER00351 ! pimeloyl-CoA from pimelate: step 1/1
relationship: part_of UPa:UER00351 {cardinality="1", direction="LR", order="1"} ! pimeloyl-CoA from pimelate: step 1/1

[Term]
id: UPa:UCR03210
name: L-alanine + pimeloyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA
namespace: reaction
xref: KEGG:R03210 "KEGG reaction"
xref: METACYC:7KAPSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20715 "Rhea reaction"
xref: RHEA:42291 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_input_compound UPa:UPC00041 ! L-alanine
relationship: has_input_compound UPa:UPC01063 ! pimeloyl-CoA
relationship: has_input_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC01092 ! 8-amino-7-oxononanoate
relationship: has_output_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate
relationship: part_of UPa:UER00159 {cardinality="1", direction="LR", order="1"} ! 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1
relationship: part_of UPa:UER00159 ! 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1

[Term]
id: UPa:UCR03217
name: L-cysteine + O-acetyl-L-homoserine = L-cystathionine + acetate
namespace: reaction
xref: KEGG:R03217 "KEGG reaction"
xref: METACYC:RXN-721 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:30934 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_input_compound UPa:UPC01077 ! O-acetyl-L-homoserine
relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine
relationship: has_output_compound UPa:UPC02291 ! L-cystathionine
relationship: part_of UPa:UER00448 ! L-cystathionine from O-acetyl-L-homoserine: step 1/1
relationship: part_of UPa:UER00448 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-acetyl-L-homoserine: step 1/1

[Term]
id: UPa:UCR03220
name: O(2) + coproporphyrinogen-III = 2 CO(2) + 2 H(2)O + protoporphyrinogen-IX
namespace: reaction
xref: KEGG:R03220 "KEGG reaction"
xref: METACYC:RXN0-1461 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18260 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III
relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX
relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX
relationship: part_of UPa:UER00322 ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1
relationship: part_of UPa:UER00322 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1

[Term]
id: UPa:UCR03222
name: 3 O(2) + protoporphyrinogen-IX = 3 H(2)O(2) + protoporphyrin-IX
namespace: reaction
xref: KEGG:R03222 "KEGG reaction"
xref: METACYC:PROTOPORGENOXI-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25579 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX
relationship: has_input_compound UPa:UPC01079 ! protoporphyrinogen-IX
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC02191 ! protoporphyrin-IX
relationship: has_output_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX
relationship: part_of UPa:UER00324 {cardinality="1", direction="LR", order="1"} ! protoporphyrin-IX from protoporphyrinogen-IX: step 1/1
relationship: part_of UPa:UER00324 ! protoporphyrin-IX from protoporphyrinogen-IX: step 1/1

[Term]
id: UPa:UCR03223
name: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole = diphosphate + thiamine phosphate
namespace: reaction
xref: KEGG:R03223 "KEGG reaction"
xref: METACYC:THI-P-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22331 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole
relationship: has_input_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole
relationship: has_input_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine
relationship: has_input_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate
relationship: has_output_compound UPa:UPC01081 ! thiamine phosphate
relationship: part_of UPa:UER00141 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1
relationship: part_of UPa:UER00141 ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1

[Term]
id: UPa:UCR03230
name: acetyl-CoA + deacetylvindoline = CoA + vindoline
namespace: reaction
xref: KEGG:R03230 "KEGG reaction"
xref: METACYC:2.3.1.107-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24499 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC01091 ! deacetylvindoline
relationship: has_input_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC01626 ! vindoline
relationship: has_output_compound UPa:UPC01626 {cardinality="1"} ! vindoline
relationship: part_of UPa:UER00526 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 6/6
relationship: part_of UPa:UER00526 ! vindoline from tabersonine: step 6/6

[Term]
id: UPa:UCR03231
name: 8-amino-7-oxononanoate + S-adenosyl-L-methionine = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoic acid
namespace: reaction
xref: KEGG:R03231 "KEGG reaction"
xref: METACYC:DAPASYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16864 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC01092 ! 8-amino-7-oxononanoate
relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate
relationship: has_output_compound UPa:UPC01037 ! 7,8-diaminononanoate
relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate
relationship: has_output_compound UPa:UPC04425 ! S-adenosyl-4-methylthio-2-oxobutanoic acid
relationship: has_output_compound UPa:UPC04425 {cardinality="1"} ! S-adenosyl-4-methylthio-2-oxobutanoic acid
relationship: part_of UPa:UER00160 ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1
relationship: part_of UPa:UER00160 {cardinality="1", direction="LR", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1

[Term]
id: UPa:UCR03236
name: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate
namespace: reaction
xref: KEGG:R03236 "KEGG reaction"
xref: METACYC:TAGAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12423 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01097 ! D-tagatose 6-phosphate
relationship: has_input_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate
relationship: has_output_compound UPa:UPC03785 ! D-tagatose 1,6-bisphosphate
relationship: part_of UPa:UER00715 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2
relationship: part_of UPa:UER00715 ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2

[Term]
id: UPa:UCR03240
name: D-galactose 6-phosphate = D-tagatose 6-phosphate
namespace: reaction
xref: KEGG:R03240 "KEGG reaction"
xref: METACYC:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13036 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate
relationship: has_input_compound UPa:UPC01113 ! D-galactose 6-phosphate
relationship: has_output_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate
relationship: has_output_compound UPa:UPC01097 ! D-tagatose 6-phosphate
relationship: part_of UPa:UER00714 {cardinality="1", direction="LR", order="1"} ! D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1
relationship: part_of UPa:UER00714 ! D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1

[Term]
id: UPa:UCR03241
name: ATP + L-fuculose = ADP + L-fuculose 1-phosphate
namespace: reaction
xref: KEGG:R03241 "KEGG reaction"
xref: METACYC:FUCULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12379 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose
relationship: has_input_compound UPa:UPC01721 ! L-fuculose
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate
relationship: has_output_compound UPa:UPC01099 ! L-fuculose 1-phosphate
relationship: part_of UPa:UER00625 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3
relationship: part_of UPa:UER00625 ! L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3

[Term]
id: UPa:UCR03243
name: 2-oxoglutarate + L-histidinol phosphate = L-glutamate + imidazole-acetol phosphate
namespace: reaction
xref: KEGG:R03243 "KEGG reaction"
xref: METACYC:HISTAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23747 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC01100 ! L-histidinol phosphate
relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate
relationship: has_output_compound UPa:UPC01267 ! imidazole-acetol phosphate
relationship: part_of UPa:UER00012 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9
relationship: part_of UPa:UER00012 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9

[Term]
id: UPa:UCR03244
name: L-ribulose 5-phosphate = L-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R03244 "KEGG reaction"
xref: METACYC:LXULRU5P-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18500 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC03291 ! L-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate
relationship: part_of UPa:UER00379 ! D-xylulose 5-phosphate from L-ascorbate: step 3/4
relationship: part_of UPa:UER00379 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 3/4

[Term]
id: UPa:UCR03245
name: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP
namespace: reaction
xref: KEGG:R03245 "KEGG reaction"
xref: METACYC:PHOSPHOMEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16344 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate
relationship: has_input_compound UPa:UPC01107 ! (R)-5-phosphomevalonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01143 ! (R)-5-diphosphomevalonate
relationship: has_output_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate
relationship: part_of UPa:UER00099 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 2/3
relationship: part_of UPa:UER00099 ! isopentenyl diphosphate from (R)-mevalonate: step 2/3

[Term]
id: UPa:UCR03254
name: 8-phospho-3-deoxy-D-manno-octulosonate + phosphate = D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate
namespace: reaction
xref: KEGG:R03254 "KEGG reaction"
xref: METACYC:KDO-8PSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14056 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate
relationship: has_output_compound UPa:UPC01112 ! D-arabinose 5-phosphate
relationship: part_of UPa:UER00474 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3
relationship: part_of UPa:UER00474 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3

[Term]
id: UPa:UCR03256
name: H(2)O + lactose 6-phosphate = D-galactose 6-phosphate + beta-D-glucose
namespace: reaction
xref: KEGG:R03256 "KEGG reaction"
xref: METACYC:LACTOSE6P-HYDROXY-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42407 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC05396 ! lactose 6-phosphate
relationship: has_input_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate
relationship: has_output_compound UPa:UPC00221 ! beta-D-glucose
relationship: has_output_compound UPa:UPC00221 {cardinality="1"} ! beta-D-glucose
relationship: has_output_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate
relationship: has_output_compound UPa:UPC01113 ! D-galactose 6-phosphate
relationship: part_of UPa:UER00605 {cardinality="1", direction="LR", order="1"} ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1
relationship: part_of UPa:UER00605 ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1

[Term]
id: UPa:UCR03260
name: L-cysteine + O-succinyl-L-homoserine = L-cystathionine + succinate
namespace: reaction
xref: KEGG:R03260 "KEGG reaction"
xref: METACYC:O-SUCCHOMOSERLYASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20400 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC01118 ! O-succinyl-L-homoserine
relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine
relationship: has_output_compound UPa:UPC02291 ! L-cystathionine
relationship: part_of UPa:UER00077 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-succinyl-L-homoserine: step 1/1
relationship: part_of UPa:UER00077 ! L-cystathionine from O-succinyl-L-homoserine: step 1/1

[Term]
id: UPa:UCR03269
name: N-[(R)-4-phosphonopantothenoyl]-L-cysteine = CO(2) + pantotheine 4'-phosphate
namespace: reaction
xref: KEGG:R03269 "KEGG reaction"
xref: METACYC:P-PANTOCYSDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16796 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine
relationship: has_input_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC01134 ! pantotheine 4'-phosphate
relationship: has_output_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate
relationship: part_of UPa:UER00354 ! CoA from (R)-pantothenate: step 3/5
relationship: part_of UPa:UER00354 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 3/5

[Term]
id: UPa:UCR03298
name: 2,3-bisphospho-D-glycerate + ATP = ADP + cyclic 2,3-diphosphoglycerate + phosphate
namespace: reaction
xref: KEGG:R03298 "KEGG reaction"
xref: RHEA:42415 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01159 ! 2,3-bisphospho-D-glycerate
relationship: has_input_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC06189 ! cyclic 2,3-diphosphoglycerate
relationship: has_output_compound UPa:UPC06189 {cardinality="1"} ! cyclic 2,3-diphosphoglycerate
relationship: part_of UPa:UER00610 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2
relationship: part_of UPa:UER00610 ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2

[Term]
id: UPa:UCR03303
name: (3,4-dihydroxyphenyl)acetate + O(2) = 5-carboxymethyl-2-hydroxymuconate semialdehyde
namespace: reaction
xref: KEGG:R03303 "KEGG reaction"
xref: METACYC:1.13.11.15-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15636 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC01161 ! (3,4-dihydroxyphenyl)acetate
relationship: has_input_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate
relationship: has_output_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde
relationship: has_output_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde
relationship: part_of UPa:UER00417 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7
relationship: part_of UPa:UER00417 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7

[Term]
id: UPa:UCR03307
name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
namespace: reaction
xref: KEGG:R03307 "KEGG reaction"
xref: METACYC:5.5.1.2-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23659 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate
relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate
relationship: part_of UPa:UER00265 {cardinality="1", direction="RL", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2
relationship: part_of UPa:UER00265 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2

[Term]
id: UPa:UCR03308
name: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
namespace: reaction
xref: KEGG:R03308 "KEGG reaction"
xref: METACYC:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14980 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04553 ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_input_compound UPa:UPC04553 {cardinality="1"} ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate
relationship: has_output_compound UPa:UPC01163 ! 3-carboxy-cis,cis-muconate
relationship: part_of UPa:UER00308 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1
relationship: part_of UPa:UER00308 ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1

[Term]
id: UPa:UCR03313
name: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH
namespace: reaction
xref: KEGG:R03313 "KEGG reaction"
xref: METACYC:GLUTSEMIALDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19544 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde
relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate
relationship: has_output_compound UPa:UPC03287 ! L-glutamyl 5-phosphate
relationship: part_of UPa:UER00360 ! L-glutamate 5-semialdehyde from L-glutamate: step 2/2
relationship: part_of UPa:UER00360 {cardinality="1", direction="RL", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 2/2

[Term]
id: UPa:UCR03314
name: L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylic acid + H(2)O
namespace: reaction
xref: KEGG:R03314 "KEGG reaction"
xref: METACYC:SPONTPRO-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:28237 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01165 ! L-glutamate 5-semialdehyde
relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid
relationship: has_output_compound UPa:UPC03912 ! (S)-1-pyrroline-5-carboxylic acid
relationship: part_of UPa:UER00361 ! L-proline from L-glutamate 5-semialdehyde: step 1/1
relationship: part_of UPa:UER00361 {cardinality="1", direction="LR", order="1"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1

[Term]
id: UPa:UCR03348
name: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + quinolinate
namespace: reaction
xref: KEGG:R03348 "KEGG reaction"
xref: METACYC:QUINOPRIBOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12736 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_input_compound UPa:UPC00013 ! diphosphate
relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide
relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC03722 ! quinolinate
relationship: has_output_compound UPa:UPC03722 {cardinality="1"} ! quinolinate
relationship: part_of UPa:UER00331 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from quinolinate: step 1/1
relationship: part_of UPa:UER00331 ! nicotinate D-ribonucleotide from quinolinate: step 1/1

[Term]
id: UPa:UCR03350
name: 8-phospho-3-deoxy-D-manno-octulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate
namespace: reaction
xref: KEGG:R03350 "KEGG reaction"
xref: METACYC:KDO-8PPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11503 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04478 ! 8-phospho-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate
relationship: has_output_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate
relationship: part_of UPa:UER00475 {cardinality="1", direction="LR", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3
relationship: part_of UPa:UER00475 ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3

[Term]
id: UPa:UCR03351
name: 3-deoxy-D-manno-octulosonate + CTP = CMP-3-deoxy-D-manno-octulosonate + diphosphate
namespace: reaction
xref: KEGG:R03351 "KEGG reaction"
xref: METACYC:CPM-KDOSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23451 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC01187 ! 3-deoxy-D-manno-octulosonate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate
relationship: has_output_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate
relationship: part_of UPa:UER00476 ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1
relationship: part_of UPa:UER00476 {cardinality="1", direction="LR", order="1"} ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1

[Term]
id: UPa:UCR03387
name: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonic acid + ADP
namespace: reaction
xref: KEGG:R03387 "KEGG reaction"
xref: METACYC:DEHYDDEOXGALACTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16528 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC01216 ! 2-dehydro-3-deoxy-D-galactonate
relationship: has_input_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid
relationship: has_output_compound UPa:UPC01286 ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid
relationship: part_of UPa:UER00519 ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3
relationship: part_of UPa:UER00519 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3

[Term]
id: UPa:UCR03390
name: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran
namespace: reaction
xref: KEGG:R03390 "KEGG reaction"
xref: METACYC:2.3.1.101-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18064 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01001 ! N-formylmethanofuran
relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran
relationship: has_input_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran
relationship: has_output_compound UPa:UPC00862 ! methanofuran
relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin
relationship: part_of UPa:UER00693 {cardinality="1", direction="LR", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3
relationship: part_of UPa:UER00693 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3
relationship: part_of UPa:UER00704 ! formate from formaldehyde (H(4)MPT route): step 4/5
relationship: part_of UPa:UER00704 {cardinality="1", direction="RL", order="1"} ! formate from formaldehyde (H(4)MPT route): step 4/5

[Term]
id: UPa:UCR03391
name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NAD(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADH
namespace: reaction
xref: KEGG:R03391 "KEGG reaction"
xref: RHEA:19656 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: part_of UPa:UER00967 ! None
relationship: part_of UPa:UER00967 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR03392
name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NADP(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADPH
namespace: reaction
xref: KEGG:R03392 "KEGG reaction"
xref: METACYC:1.17.1.1-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19660 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01219 ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose
relationship: part_of UPa:UER00968 ! None
relationship: part_of UPa:UER00968 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR03409
name: H(2)O + guanosine 3'-diphosphate 5'-triphosphate = phosphate + ppGpp
namespace: reaction
xref: KEGG:R03409 "KEGG reaction"
xref: METACYC:PPPGPPHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13076 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC04494 ! guanosine 3'-diphosphate 5'-triphosphate
relationship: has_input_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC01228 ! ppGpp
relationship: has_output_compound UPa:UPC01228 {cardinality="1"} ! ppGpp
relationship: part_of UPa:UER00885 ! ppGpp from GTP: step 2/2
relationship: part_of UPa:UER00885 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 2/2

[Term]
id: UPa:UCR03418
name: 1-alpha-D-galactosyl-myo-inositol + raffinose = myo-inositol + stachyose
namespace: reaction
xref: KEGG:R03418 "KEGG reaction"
xref: METACYC:2.4.1.67-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20779 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00492 ! raffinose
relationship: has_input_compound UPa:UPC00492 {cardinality="1"} ! raffinose
relationship: has_input_compound UPa:UPC01235 ! 1-alpha-D-galactosyl-myo-inositol
relationship: has_input_compound UPa:UPC01235 {cardinality="1"} ! 1-alpha-D-galactosyl-myo-inositol
relationship: has_output_compound UPa:UPC00137 ! myo-inositol
relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol
relationship: has_output_compound UPa:UPC01613 ! stachyose
relationship: has_output_compound UPa:UPC01613 {cardinality="1"} ! stachyose
relationship: part_of UPa:UER00892 {cardinality="1", direction="LR", order="1"} ! stachyose from raffinose: step 1/1
relationship: part_of UPa:UER00892 ! stachyose from raffinose: step 1/1

[Term]
id: UPa:UCR03443
name: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH
namespace: reaction
xref: KEGG:R03443 "KEGG reaction"
xref: METACYC:N-ACETYLGLUTPREDUCT-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21591 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde
relationship: has_input_compound UPa:UPC01250 ! N-acetyl-L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate
relationship: has_output_compound UPa:UPC04133 ! N-acetyl-L-glutamyl 5-phosphate
relationship: part_of UPa:UER00108 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 3/4
relationship: part_of UPa:UER00108 ! N(2)-acetyl-L-ornithine from L-glutamate: step 3/4

[Term]
id: UPa:UCR03444
name: (R)-homocitrate = H(2)O + homo-cis-aconitate
namespace: reaction
xref: KEGG:R03444 "KEGG reaction"
xref: METACYC:RXN3O-1983 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26104 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate
relationship: has_input_compound UPa:UPC01251 ! (R)-homocitrate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC04002 ! homo-cis-aconitate
relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate
relationship: part_of UPa:UER00029 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 2/5
relationship: part_of UPa:UER00029 ! L-alpha-aminoadipate from 2-oxoglutarate: step 2/5

[Term]
id: UPa:UCR03445
name: 4-(2-aminophenyl)-2,4-dioxobutanoate = H(2)O + kynurenate
namespace: reaction
xref: KEGG:R03445 "KEGG reaction"
xref: METACYC:RXN-10720 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42455 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate
relationship: has_input_compound UPa:UPC01252 ! 4-(2-aminophenyl)-2,4-dioxobutanoate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC01717 ! kynurenate
relationship: has_output_compound UPa:UPC01717 {cardinality="1"} ! kynurenate
relationship: part_of UPa:UER00727 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 2/2
relationship: part_of UPa:UER00727 ! kynurenate from L-kynurenine: step 2/2

[Term]
id: UPa:UCR03457
name: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = H(2)O + imidazole-acetol phosphate
namespace: reaction
xref: KEGG:R03457 "KEGG reaction"
xref: METACYC:IMIDPHOSDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11043 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
relationship: has_input_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate
relationship: has_output_compound UPa:UPC01267 ! imidazole-acetol phosphate
relationship: part_of UPa:UER00011 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9
relationship: part_of UPa:UER00011 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9

[Term]
id: UPa:UCR03458
name: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH
namespace: reaction
xref: KEGG:R03458 "KEGG reaction"
xref: METACYC:RIBOFLAVINSYNREDUC-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17848 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil
relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil
relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil
relationship: part_of UPa:UER00402 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4
relationship: part_of UPa:UER00402 {cardinality="1", direction="RL", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4

[Term]
id: UPa:UCR03459
name: 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3)
namespace: reaction
xref: KEGG:R03459 "KEGG reaction"
xref: METACYC:RIBOFLAVINSYNDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21871 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
relationship: has_input_compound UPa:UPC01304 ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC01268 ! 5-amino-6-(5-phosphoribosylamino)uracil
relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil
relationship: part_of UPa:UER00401 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4
relationship: part_of UPa:UER00401 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4

[Term]
id: UPa:UCR03460
name: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
namespace: reaction
xref: KEGG:R03460 "KEGG reaction"
xref: METACYC:2.5.1.19-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21259 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: has_input_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_input_compound UPa:UPC03175 ! 3-phosphoshikimate
relationship: has_input_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate
relationship: has_output_compound UPa:UPC01269 ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate
relationship: part_of UPa:UER00089 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7
relationship: part_of UPa:UER00089 ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7

[Term]
id: UPa:UCR03462
name: O(2) + biphenyl-2,3-diol = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
namespace: reaction
xref: KEGG:R03462 "KEGG reaction"
xref: METACYC:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14416 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC02526 ! biphenyl-2,3-diol
relationship: has_input_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol
relationship: has_output_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
relationship: has_output_compound UPa:UPC01273 ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
relationship: part_of UPa:UER00252 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4
relationship: part_of UPa:UER00252 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4

[Term]
id: UPa:UCR03464
name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
namespace: reaction
xref: KEGG:R03464 "KEGG reaction"
xref: METACYC:3.5.4.27-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19056 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC01274 ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin
relationship: part_of UPa:UER00694 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3
relationship: part_of UPa:UER00694 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3
relationship: part_of UPa:UER00703 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 3/5
relationship: part_of UPa:UER00703 ! formate from formaldehyde (H(4)MPT route): step 3/5

[Term]
id: UPa:UCR03470
name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 5-oxo-4,5-dihydro-2-furylacetate + CO(2)
namespace: reaction
xref: KEGG:R03470 "KEGG reaction"
xref: METACYC:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23351 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_input_compound UPa:UPC01278 ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: part_of UPa:UER00266 ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2
relationship: part_of UPa:UER00266 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2

[Term]
id: UPa:UCR03471
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP
namespace: reaction
xref: KEGG:R03471 "KEGG reaction"
xref: METACYC:OHMETPYRKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23099 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine
relationship: has_input_compound UPa:UPC01279 ! 4-amino-5-hydroxymethyl-2-methylpyrimidine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine
relationship: has_output_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine
relationship: part_of UPa:UER00137 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3
relationship: part_of UPa:UER00137 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3

[Term]
id: UPa:UCR03503
name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + AMP
namespace: reaction
xref: KEGG:R03503 "KEGG reaction"
xref: METACYC:H2PTERIDINEPYROPHOSPHOKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11415 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
relationship: has_input_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC04807 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
relationship: has_output_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
relationship: part_of UPa:UER00155 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4
relationship: part_of UPa:UER00155 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4

[Term]
id: UPa:UCR03504
name: 7,8-dihydroneopterin = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
namespace: reaction
xref: KEGG:R03504 "KEGG reaction"
xref: METACYC:H2NEOPTERINALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10543 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin
relationship: has_input_compound UPa:UPC04874 ! 7,8-dihydroneopterin
relationship: has_output_compound UPa:UPC00266 ! glycolaldehyde
relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde
relationship: has_output_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
relationship: has_output_compound UPa:UPC01300 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
relationship: part_of UPa:UER00154 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4
relationship: part_of UPa:UER00154 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4

[Term]
id: UPa:UCR03508
name: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = CO(2) + H(2)O + indoleglycerol phosphate
namespace: reaction
xref: KEGG:R03508 "KEGG reaction"
xref: METACYC:IGPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23479 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate
relationship: has_output_compound UPa:UPC03506 ! indoleglycerol phosphate
relationship: part_of UPa:UER00043 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 4/5
relationship: part_of UPa:UER00043 ! L-tryptophan from chorismate: step 4/5

[Term]
id: UPa:UCR03509
name: N-(5-phospho-beta-D-ribosyl)anthranilic acid = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
namespace: reaction
xref: KEGG:R03509 "KEGG reaction"
xref: METACYC:PRAISOM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21543 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid
relationship: has_input_compound UPa:UPC04302 ! N-(5-phospho-beta-D-ribosyl)anthranilic acid
relationship: has_output_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC01302 ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
relationship: part_of UPa:UER00042 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 3/5
relationship: part_of UPa:UER00042 ! L-tryptophan from chorismate: step 3/5

[Term]
id: UPa:UCR03534
name: 2-hydroxyglutarate + FAD = 2-oxoglutarate + FADH2
namespace: reaction
xref: KEGG:R03534 "KEGG reaction"
xref: METACYC:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:21255 "Rhea reaction"
xref: RHEA:25264 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00016 ! FAD
relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD
relationship: has_input_compound UPa:UPC02630 ! 2-hydroxyglutarate
relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC01352 ! FADH2
relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2
relationship: part_of UPa:UER00685 ! crotonoyl-CoA from L-glutamate: step 2/5
relationship: part_of UPa:UER00685 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 2/5

[Term]
id: UPa:UCR03543
name: H(+) + NADH + O(2) + benzene = NAD(+) + cis-1,2-dihydrobenzene-1,2-diol
namespace: reaction
xref: KEGG:R03543 "KEGG reaction"
xref: METACYC:BENZENE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13816 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC01407 {cardinality="1"} ! benzene
relationship: has_input_compound UPa:UPC01407 ! benzene
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol
relationship: has_output_compound UPa:UPC04091 ! cis-1,2-dihydrobenzene-1,2-diol
relationship: part_of UPa:UER00391 ! catechol from benzene: step 1/2
relationship: part_of UPa:UER00391 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 1/2

[Term]
id: UPa:UCR03559
name: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)
namespace: reaction
xref: KEGG:R03559 "KEGG reaction"
xref: METACYC:TOLUENE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16740 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC01455 ! toluene
relationship: has_input_compound UPa:UPC01455 {cardinality="1"} ! toluene
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol
relationship: has_output_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol
relationship: part_of UPa:UER00393 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 1/2
relationship: part_of UPa:UER00393 ! 3-methylcatechol from toluene: step 1/2

[Term]
id: UPa:UCR03630
name: H(+) + NADH + O(2) + phthalate = NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
namespace: reaction
xref: KEGG:R03630 "KEGG reaction"
xref: METACYC:PHTHALATE-45-DIOXYGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17492 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC01606 {cardinality="1"} ! phthalate
relationship: has_input_compound UPa:UPC01606 ! phthalate
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
relationship: has_output_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
relationship: part_of UPa:UER00728 ! 3,4-dihydroxybenzoate from phthalate: step 1/3
relationship: part_of UPa:UER00728 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 1/3

[Term]
id: UPa:UCR03693
name: L-citramalate = H(2)O + mesaconate
namespace: reaction
xref: KEGG:R03693 "KEGG reaction"
xref: METACYC:S-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13532 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02614 ! L-citramalate
relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate
relationship: has_output_compound UPa:UPC01732 ! mesaconate
relationship: part_of UPa:UER00619 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 3/4
relationship: part_of UPa:UER00619 ! acetate and pyruvate from L-glutamate: step 3/4

[Term]
id: UPa:UCR03696
name: (2S,3S)-3-methyl-L-aspartate = NH(3) + mesaconate
namespace: reaction
xref: KEGG:R03696 "KEGG reaction"
xref: METACYC:METHYLASPARTATE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12832 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03618 ! (2S,3S)-3-methyl-L-aspartate
relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate
relationship: has_output_compound UPa:UPC01732 ! mesaconate
relationship: part_of UPa:UER00618 ! acetate and pyruvate from L-glutamate: step 2/4
relationship: part_of UPa:UER00618 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 2/4

[Term]
id: UPa:UCR03721
name: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine
namespace: reaction
xref: KEGG:R03721 "KEGG reaction"
xref: METACYC:2.1.1.118-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15376 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC01795 ! columbamine
relationship: has_input_compound UPa:UPC01795 {cardinality="1"} ! columbamine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC05315 ! palmatine
relationship: has_output_compound UPa:UPC05315 {cardinality="1"} ! palmatine
relationship: part_of UPa:UER00445 {cardinality="1", direction="LR", order="1"} ! palmatine from columbamine: step 1/1
relationship: part_of UPa:UER00445 ! palmatine from columbamine: step 1/1

[Term]
id: UPa:UCR03738
name: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine
namespace: reaction
xref: KEGG:R03738 "KEGG reaction"
xref: METACYC:STRICTOSIDINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15016 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03470 {cardinality="1"} ! 3alpha(S)-strictosidine
relationship: has_input_compound UPa:UPC03470 ! 3alpha(S)-strictosidine
relationship: has_output_compound UPa:UPC00398 ! tryptamine
relationship: has_output_compound UPa:UPC00398 {cardinality="1"} ! tryptamine
relationship: has_output_compound UPa:UPC01852 {cardinality="1"} ! secologanin
relationship: has_output_compound UPa:UPC01852 ! secologanin
relationship: part_of UPa:UER00447 ! 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1
relationship: part_of UPa:UER00447 {cardinality="1", direction="RL", order="1"} ! 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1

[Term]
id: UPa:UCR03791
name: (S)-mandelate = (R)-mandelate
namespace: reaction
xref: KEGG:R03791 "KEGG reaction"
xref: METACYC:MANDELATE-RACEMASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13948 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate
relationship: has_input_compound UPa:UPC01984 ! (S)-mandelate
relationship: has_output_compound UPa:UPC01983 {cardinality="1"} ! (R)-mandelate
relationship: has_output_compound UPa:UPC01983 ! (R)-mandelate
relationship: part_of UPa:UER00852 ! benzoate from (R)-mandelate: step 1/4
relationship: part_of UPa:UER00852 {cardinality="1", direction="RL", order="1"} ! benzoate from (R)-mandelate: step 1/4

[Term]
id: UPa:UCR03793
name: (S)-mandelate + acceptor = phenylglyoxylate + reduced acceptor
namespace: reaction
xref: KEGG:R03793 "KEGG reaction"
xref: METACYC:MANDELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15752 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00028 ! acceptor
relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate
relationship: has_input_compound UPa:UPC01984 ! (S)-mandelate
relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_output_compound UPa:UPC00030 ! reduced acceptor
relationship: has_output_compound UPa:UPC02137 ! phenylglyoxylate
relationship: has_output_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate
relationship: part_of UPa:UER00853 ! benzoate from (R)-mandelate: step 2/4
relationship: part_of UPa:UER00853 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 2/4

[Term]
id: UPa:UCR03831
name: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2)
namespace: reaction
xref: KEGG:R03831 "KEGG reaction"
xref: METACYC:RETICULINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19888 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC02105 ! (S)-reticuline
relationship: has_input_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC02106 ! (S)-scoulerine
relationship: has_output_compound UPa:UPC02106 {cardinality="1"} ! (S)-scoulerine
relationship: part_of UPa:UER00450 ! (S)-scoulerine from (S)-reticuline: step 1/1
relationship: part_of UPa:UER00450 {cardinality="1", direction="LR", order="1"} ! (S)-scoulerine from (S)-reticuline: step 1/1

[Term]
id: UPa:UCR03832
name: (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R03832 "KEGG reaction"
xref: METACYC:2.1.1.116-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17792 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine
relationship: has_input_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC02105 ! (S)-reticuline
relationship: has_output_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline
relationship: part_of UPa:UER00444 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 4/4
relationship: part_of UPa:UER00444 ! (S)-reticuline from (S)-norcoclaurine: step 4/4

[Term]
id: UPa:UCR03892
name: maleylacetate = 3-hydroxy-cis,cis-muconate
namespace: reaction
xref: KEGG:R03892 "KEGG reaction"
xref: METACYC:RXN-9922 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42435 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02222 ! maleylacetate
relationship: has_input_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate
relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate
relationship: has_output_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate
relationship: part_of UPa:UER00269 {cardinality="1", direction="RL", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4
relationship: part_of UPa:UER00269 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4

[Term]
id: UPa:UCR03896
name: (R)-citramalate = 2-methylmaleate + H(2)O
namespace: reaction
xref: KEGG:R03896 "KEGG reaction"
xref: METACYC:R-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22335 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02612 ! (R)-citramalate
relationship: has_input_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate
relationship: has_output_compound UPa:UPC02226 ! 2-methylmaleate
relationship: part_of UPa:UER00067 ! 2-oxobutanoate from pyruvate: step 2/3
relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 2/3

[Term]
id: UPa:UCR03898
name: 2-methylmaleate + H(2)O = D-erythro-3-methylmalic acid
namespace: reaction
xref: KEGG:R03898 "KEGG reaction"
xref: RHEA:42427 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate
relationship: has_input_compound UPa:UPC02226 ! 2-methylmaleate
relationship: has_output_compound UPa:UPC06032 ! D-erythro-3-methylmalic acid
relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid
relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="2"} ! 2-oxobutanoate from pyruvate: step 2/3
relationship: part_of UPa:UER00067 ! 2-oxobutanoate from pyruvate: step 2/3

[Term]
id: UPa:UCR03908
name: 2-methyleneglutarate = 2-methylene-3-methylsuccinate
namespace: reaction
xref: KEGG:R03908 "KEGG reaction"
xref: METACYC:2-METHYLENEGLUTARATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13796 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02930 {cardinality="1"} ! 2-methyleneglutarate
relationship: has_input_compound UPa:UPC02930 ! 2-methyleneglutarate
relationship: has_output_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate
relationship: has_output_compound UPa:UPC02295 ! 2-methylene-3-methylsuccinate
relationship: part_of UPa:UER01016 ! propanoate and pyruvate from 6-hydroxynicotinate: step 5/8
relationship: part_of UPa:UER01016 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 5/8

[Term]
id: UPa:UCR03932
name: 4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate
namespace: reaction
xref: KEGG:R03932 "KEGG reaction"
xref: METACYC:6.2.1.33-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23223 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC02370 ! 4-chlorobenzoate
relationship: has_input_compound UPa:UPC02370 {cardinality="1"} ! 4-chlorobenzoate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA
relationship: has_output_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA
relationship: part_of UPa:UER01020 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3
relationship: part_of UPa:UER01020 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3

[Term]
id: UPa:UCR03937
name: H(2)O + glutaconyl-1-CoA = 2-hydroxyglutaryl-CoA
namespace: reaction
xref: KEGG:R03937 "KEGG reaction"
xref: METACYC:RXN-1083 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42451 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA
relationship: has_input_compound UPa:UPC02411 ! glutaconyl-1-CoA
relationship: has_output_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA
relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA
relationship: part_of UPa:UER00687 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 4/5
relationship: part_of UPa:UER00687 ! crotonoyl-CoA from L-glutamate: step 4/5

[Term]
id: UPa:UCR03947
name: NAD(+) + precorrin-2 = H(+) + NADH + sirohydrochlorin
namespace: reaction
xref: KEGG:R03947 "KEGG reaction"
xref: METACYC:DIMETHUROPORDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15616 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC02463 ! precorrin-2
relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05778 ! sirohydrochlorin
relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin
relationship: part_of UPa:UER00222 ! sirohydrochlorin from precorrin-2: step 1/1
relationship: part_of UPa:UER00222 {cardinality="1", direction="LR", order="1"} ! sirohydrochlorin from precorrin-2: step 1/1

[Term]
id: UPa:UCR03948
name: S-adenosyl-L-methionine + precorrin-2 = H(+) + S-adenosyl-L-homocysteine + precorrin-3A
namespace: reaction
xref: KEGG:R03948 "KEGG reaction"
xref: METACYC:2.1.1.130-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16844 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC02463 ! precorrin-2
relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05772 ! precorrin-3A
relationship: has_output_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A
relationship: part_of UPa:UER00212 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10
relationship: part_of UPa:UER00212 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10

[Term]
id: UPa:UCR03968
name: (2S)-2-isopropylmalate = 2-isopropylmaleate + H(2)O
namespace: reaction
xref: KEGG:R03968 "KEGG reaction"
xref: METACYC:3-ISOPROPYLMALISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16296 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate
relationship: has_input_compound UPa:UPC02504 ! (2S)-2-isopropylmalate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC02631 ! 2-isopropylmaleate
relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate
relationship: part_of UPa:UER00071 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4
relationship: part_of UPa:UER00071 ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4

[Term]
id: UPa:UCR04000
name: 2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate
namespace: reaction
xref: KEGG:R04000 "KEGG reaction"
xref: METACYC:RXN-1082 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42079 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC02630 ! 2-hydroxyglutarate
relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA
relationship: has_output_compound UPa:UPC03058 ! 2-hydroxyglutaryl-CoA
relationship: part_of UPa:UER00686 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 3/5
relationship: part_of UPa:UER00686 ! crotonoyl-CoA from L-glutamate: step 3/5

[Term]
id: UPa:UCR04001
name: (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H(2)O
namespace: reaction
xref: KEGG:R04001 "KEGG reaction"
xref: METACYC:RXN-8991 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10679 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate
relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC02631 ! 2-isopropylmaleate
relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate
relationship: part_of UPa:UER00071 ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4
relationship: part_of UPa:UER00071 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4

[Term]
id: UPa:UCR04013
name: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + desacetoxyvindoline
namespace: reaction
xref: KEGG:R04013 "KEGG reaction"
xref: METACYC:2.1.1.99-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11339 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
relationship: has_input_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC02673 ! desacetoxyvindoline
relationship: has_output_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline
relationship: part_of UPa:UER00524 ! vindoline from tabersonine: step 4/6
relationship: part_of UPa:UER00524 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 4/6

[Term]
id: UPa:UCR04029
name: 2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate
namespace: reaction
xref: KEGG:R04029 "KEGG reaction"
xref: METACYC:ACETCAPR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:42507 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine
relationship: has_input_compound UPa:UPC02727 ! N(6)-acetyl-L-lysine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate
relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate
relationship: part_of UPa:UER00842 ! glutarate from L-lysine: step 2/6
relationship: part_of UPa:UER00842 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 2/6

[Term]
id: UPa:UCR04030
name: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate
namespace: reaction
xref: KEGG:R04030 "KEGG reaction"
xref: METACYC:O-SUCCINYLBENZOATE-COA-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17012 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate
relationship: has_input_compound UPa:UPC02730 ! 2-succinylbenzoate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA
relationship: has_output_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA
relationship: part_of UPa:UER00166 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7
relationship: part_of UPa:UER00166 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7

[Term]
id: UPa:UCR04031
name: 2-succinylbenzoate + H(2)O = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid
namespace: reaction
xref: KEGG:R04031 "KEGG reaction"
xref: METACYC:O-SUCCINYLBENZOATE-COA-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10199 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate
relationship: has_input_compound UPa:UPC02730 ! 2-succinylbenzoate
relationship: has_output_compound UPa:UPC05817 ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid
relationship: has_output_compound UPa:UPC05817 {cardinality="1"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid
relationship: part_of UPa:UER00165 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7
relationship: part_of UPa:UER00165 {cardinality="1", direction="RL", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7

[Term]
id: UPa:UCR04035
name: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-5'-AMP + diphosphate
namespace: reaction
xref: KEGG:R04035 "KEGG reaction"
xref: METACYC:HISTPRATPHYD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22831 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP
relationship: has_input_compound UPa:UPC02739 ! 1-(5-phospho-D-ribosyl)-ATP
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP
relationship: has_output_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP
relationship: part_of UPa:UER00007 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9
relationship: part_of UPa:UER00007 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9

[Term]
id: UPa:UCR04037
name: 1-(5-phosphoribosyl)-5'-AMP + H(2)O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
namespace: reaction
xref: KEGG:R04037 "KEGG reaction"
xref: METACYC:HISTCYCLOHYD-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20052 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP
relationship: has_input_compound UPa:UPC02741 ! 1-(5-phosphoribosyl)-5'-AMP
relationship: has_output_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
relationship: part_of UPa:UER00008 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9
relationship: part_of UPa:UER00008 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9

[Term]
id: UPa:UCR04061
name: O(2) + benzene-1,2,4-triol = 3-hydroxy-cis,cis-muconate
namespace: reaction
xref: KEGG:R04061 "KEGG reaction"
xref: METACYC:RXN-10137 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19444 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC02814 ! benzene-1,2,4-triol
relationship: has_input_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol
relationship: has_output_compound UPa:UPC03676 ! 3-hydroxy-cis,cis-muconate
relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate
relationship: part_of UPa:UER00268 ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4
relationship: part_of UPa:UER00268 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4

[Term]
id: UPa:UCR04088
name: (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH
namespace: reaction
xref: KEGG:R04088 "KEGG reaction"
xref: METACYC:TOLUENE-DIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25196 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol
relationship: has_input_compound UPa:UPC04592 ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC02923 {cardinality="1"} ! 3-methylcatechol
relationship: has_output_compound UPa:UPC02923 ! 3-methylcatechol
relationship: part_of UPa:UER00394 ! 3-methylcatechol from toluene: step 2/2
relationship: part_of UPa:UER00394 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 2/2

[Term]
id: UPa:UCR04095
name: 3-isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
namespace: reaction
xref: KEGG:R04095 "KEGG reaction"
xref: METACYC:RXN-14264 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:31066 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD
relationship: has_input_compound UPa:UPC00016 ! FAD
relationship: has_input_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA
relationship: has_input_compound UPa:UPC02939 ! 3-isovaleryl-CoA
relationship: has_output_compound UPa:UPC01352 ! FADH2
relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2
relationship: has_output_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA
relationship: has_output_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA
relationship: part_of UPa:UER00860 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3
relationship: part_of UPa:UER00860 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3

[Term]
id: UPa:UCR04101
name: 4-chlorobenzoyl-CoA + H(2)O = 4-hydroxybenzoyl-CoA + H(+) + chloride
namespace: reaction
xref: KEGG:R04101 "KEGG reaction"
xref: METACYC:3.8.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14856 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06387 ! 4-chlorobenzoyl-CoA
relationship: has_input_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00698 ! chloride
relationship: has_output_compound UPa:UPC00698 {cardinality="1"} ! chloride
relationship: has_output_compound UPa:UPC02949 ! 4-hydroxybenzoyl-CoA
relationship: has_output_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA
relationship: part_of UPa:UER01021 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3
relationship: part_of UPa:UER01021 ! 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3

[Term]
id: UPa:UCR04109
name: H(+) + L-glutamyl-tRNA(Glu) + NADPH = (S)-4-amino-5-oxopentanoic acid + NADP(+) + tRNA(Glu)
namespace: reaction
xref: KEGG:R04109 "KEGG reaction"
xref: METACYC:GLUTRNAREDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12347 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC02987 ! L-glutamyl-tRNA(Glu)
relationship: has_input_compound UPa:UPC02987 {cardinality="1"} ! L-glutamyl-tRNA(Glu)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC01641 {cardinality="1"} ! tRNA(Glu)
relationship: has_output_compound UPa:UPC01641 ! tRNA(Glu)
relationship: has_output_compound UPa:UPC03741 ! (S)-4-amino-5-oxopentanoic acid
relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid
relationship: part_of UPa:UER00316 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2
relationship: part_of UPa:UER00316 ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2

[Term]
id: UPa:UCR04138
name: 3-methylcrotonyl-CoA + ATP + bicarbonate = 3-methylglutaconyl-CoA + ADP + phosphate
namespace: reaction
xref: KEGG:R04138 "KEGG reaction"
xref: METACYC:METHYLCROTONYL-COA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13592 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_input_compound UPa:UPC03069 ! 3-methylcrotonyl-CoA
relationship: has_input_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC03231 ! 3-methylglutaconyl-CoA
relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA
relationship: part_of UPa:UER00861 ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3
relationship: part_of UPa:UER00861 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3

[Term]
id: UPa:UCR04142
name: 5-acetamidopentanoate + CO(2) + H(+) + NADH = 6-acetamido-2-oxohexanoate + H(2)O + NAD(+)
namespace: reaction
xref: KEGG:R04142 "KEGG reaction"
xref: METACYC:KETAMID-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42511 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00011 ! CO(2)
relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate
relationship: has_input_compound UPa:UPC03087 ! 5-acetamidopentanoate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC05548 ! 6-acetamido-2-oxohexanoate
relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate
relationship: part_of UPa:UER00843 {cardinality="1", direction="RL", order="1"} ! glutarate from L-lysine: step 3/6
relationship: part_of UPa:UER00843 ! glutarate from L-lysine: step 3/6

[Term]
id: UPa:UCR04143
name: 5-methylthio-alpha-D-ribose + ATP = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate
namespace: reaction
xref: KEGG:R04143 "KEGG reaction"
xref: METACYC:5-METHYLTHIORIBOSE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22315 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose
relationship: has_input_compound UPa:UPC03089 ! 5-methylthio-alpha-D-ribose
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: part_of UPa:UER00872 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2
relationship: part_of UPa:UER00872 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2

[Term]
id: UPa:UCR04144
name: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate
namespace: reaction
xref: KEGG:R04144 "KEGG reaction"
xref: METACYC:GLYRIBONUCSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17456 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00037 ! glycine
relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine
relationship: has_input_compound UPa:UPC03090 ! 5-phospho-beta-D-ribosylamine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: part_of UPa:UER00125 {cardinality="1", direction="LR", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2
relationship: part_of UPa:UER00125 ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2

[Term]
id: UPa:UCR04148
name: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = H(+) + alpha-ribazole 5'-phosphate + nicotinate
namespace: reaction
xref: KEGG:R04148 "KEGG reaction"
xref: METACYC:DMBPPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11199 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01185 ! nicotinate D-ribonucleotide
relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide
relationship: has_input_compound UPa:UPC03114 {cardinality="1"} ! 5,6-dimethylbenzimidazole
relationship: has_input_compound UPa:UPC03114 ! 5,6-dimethylbenzimidazole
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00253 ! nicotinate
relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate
relationship: has_output_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate
relationship: has_output_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate
relationship: part_of UPa:UER00516 ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2
relationship: part_of UPa:UER00516 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2

[Term]
id: UPa:UCR04173
name: 2-oxoglutarate + O-phospho-L-serine = 3-phosphohydroxypyruvate + L-glutamate
namespace: reaction
xref: KEGG:R04173 "KEGG reaction"
xref: METACYC:PSERTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14332 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine
relationship: has_input_compound UPa:UPC01005 ! O-phospho-L-serine
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC03232 ! 3-phosphohydroxypyruvate
relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate
relationship: part_of UPa:UER00197 {cardinality="1", direction="RL", order="1"} ! L-serine from 3-phospho-D-glycerate: step 2/3
relationship: part_of UPa:UER00197 ! L-serine from 3-phospho-D-glycerate: step 2/3

[Term]
id: UPa:UCR04189
name: 2 H(2)O + N(2)-succinyl-L-arginine = CO(2) + N(2)-succinyl-L-ornithine + 2 NH(3)
namespace: reaction
xref: KEGG:R04189 "KEGG reaction"
xref: METACYC:SUCCARGDIHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19536 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine
relationship: has_input_compound UPa:UPC03296 ! N(2)-succinyl-L-arginine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine
relationship: has_output_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine
relationship: part_of UPa:UER00280 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 2/5
relationship: part_of UPa:UER00280 ! L-glutamate and succinate from L-arginine: step 2/5

[Term]
id: UPa:UCR04198
name: (S)-tetrahydrodipicolinate + H(2)O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH
namespace: reaction
xref: KEGG:R04198 "KEGG reaction"
xref: RHEA:35326 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate
relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
relationship: part_of UPa:UER01028 ! None
relationship: part_of UPa:UER01028 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR04199
name: (S)-tetrahydrodipicolinate + H(2)O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH
namespace: reaction
xref: KEGG:R04199 "KEGG reaction"
xref: RHEA:35334 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate
relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC20258 ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
relationship: part_of UPa:UER01029 ! None
relationship: part_of UPa:UER01029 {cardinality="1", direction="RL", order="1"} ! None

[Term]
id: UPa:UCR04208
name: 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate
namespace: reaction
xref: KEGG:R04208 "KEGG reaction"
xref: METACYC:AIRS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23035 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine
relationship: has_input_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: part_of UPa:UER00129 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2
relationship: part_of UPa:UER00129 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2

[Term]
id: UPa:UCR04209
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
namespace: reaction
xref: KEGG:R04209 "KEGG reaction"
xref: METACYC:AIRCARBOXY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10795 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_output_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: part_of UPa:UER00130 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1
relationship: part_of UPa:UER00130 {cardinality="1", direction="RL", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1

[Term]
id: UPa:UCR04210
name: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + H(+) + NADH
namespace: reaction
xref: KEGG:R04210 "KEGG reaction"
xref: METACYC:ERYTHRON4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18832 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate
relationship: has_input_compound UPa:UPC03393 ! 4-phospho-D-erythronate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid
relationship: has_output_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid
relationship: part_of UPa:UER00310 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5
relationship: part_of UPa:UER00310 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5

[Term]
id: UPa:UCR04217
name: 2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde
namespace: reaction
xref: KEGG:R04217 "KEGG reaction"
xref: METACYC:SUCCORNTRANSAM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16956 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine
relationship: has_input_compound UPa:UPC03415 ! N(2)-succinyl-L-ornithine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde
relationship: part_of UPa:UER00281 ! L-glutamate and succinate from L-arginine: step 3/5
relationship: part_of UPa:UER00281 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 3/5

[Term]
id: UPa:UCR04218
name: prephytoene diphosphate = 15-cis-phytoene + diphosphate
namespace: reaction
xref: KEGG:R04218 "KEGG reaction"
xref: RHEA:34482 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate
relationship: has_input_compound UPa:UPC03427 ! prephytoene diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC05421 {cardinality="1"} ! 15-cis-phytoene
relationship: has_output_compound UPa:UPC05421 ! 15-cis-phytoene
relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="2"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1
relationship: part_of UPa:UER01030 ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1

[Term]
id: UPa:UCR04231
name: (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + N-[(R)-4-phosphonopantothenoyl]-L-cysteine + diphosphate
namespace: reaction
xref: KEGG:R04231 "KEGG reaction"
xref: METACYC:P-PANTOCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19400 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_input_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate
relationship: has_input_compound UPa:UPC03492 ! (R)-4'-phosphopantothenate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine
relationship: has_output_compound UPa:UPC04352 ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine
relationship: part_of UPa:UER00353 ! CoA from (R)-pantothenate: step 2/5
relationship: part_of UPa:UER00353 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 2/5

[Term]
id: UPa:UCR04265
name: CDP-3,6-dideoxy-D-glucose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-D-glucose + H(+) + NADPH
namespace: reaction
xref: KEGG:R04265 "KEGG reaction"
xref: METACYC:RXN-9159 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:34570 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose
relationship: has_input_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: has_output_compound UPa:UPC04297 ! CDP-4-dehydro-3,6-dideoxy-D-glucose
relationship: part_of UPa:UER00514 {cardinality="1", direction="RL", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5
relationship: part_of UPa:UER00514 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5

[Term]
id: UPa:UCR04266
name: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose
namespace: reaction
xref: KEGG:R04266 "KEGG reaction"
xref: METACYC:RXN-9160 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21659 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose
relationship: has_input_compound UPa:UPC03598 ! CDP-3,6-dideoxy-D-glucose
relationship: has_output_compound UPa:UPC03599 ! CDP-3,6-dideoxy-D-mannose
relationship: has_output_compound UPa:UPC03599 {cardinality="1"} ! CDP-3,6-dideoxy-D-mannose
relationship: part_of UPa:UER00515 ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5
relationship: part_of UPa:UER00515 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5

[Term]
id: UPa:UCR04285
name: 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-tetrahydropterin + H(+) + NADPH
namespace: reaction
xref: KEGG:R04285 "KEGG reaction"
xref: METACYC:1.1.1.220-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11775 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC04244 ! 6-lactoyl-5,6,7,8-tetrahydropterin
relationship: has_input_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin
relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin
relationship: part_of UPa:UER00820 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3
relationship: part_of UPa:UER00820 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3

[Term]
id: UPa:UCR04286
name: 7,8-dihydroneopterin triphosphate = 6-pyruvoyl-tetrahydropterin + triphosphate
namespace: reaction
xref: KEGG:R04286 "KEGG reaction"
xref: METACYC:4.2.3.12-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22051 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate
relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate
relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate
relationship: has_output_compound UPa:UPC00536 ! triphosphate
relationship: has_output_compound UPa:UPC03684 ! 6-pyruvoyl-tetrahydropterin
relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin
relationship: part_of UPa:UER00819 ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3
relationship: part_of UPa:UER00819 {cardinality="1", direction="LR", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3

[Term]
id: UPa:UCR04292
name: 2 H(2)O + phosphate + quinolinate = glycerone phosphate + iminoaspartate
namespace: reaction
xref: KEGG:R04292 "KEGG reaction"
xref: METACYC:QUINOLINATE-SYNTHA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25891 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate
relationship: has_input_compound UPa:UPC03722 ! quinolinate
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC05840 ! iminoaspartate
relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate
relationship: part_of UPa:UER00327 {cardinality="1", direction="RL", order="1"} ! quinolinate from iminoaspartate: step 1/1
relationship: part_of UPa:UER00327 ! quinolinate from iminoaspartate: step 1/1

[Term]
id: UPa:UCR04293
name: H(2)O + quinolinate = 2-amino-3-carboxymuconate semialdehyde
namespace: reaction
xref: KEGG:R04293 "KEGG reaction"
xref: METACYC:RXN-5721 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25150 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate
relationship: has_input_compound UPa:UPC03722 ! quinolinate
relationship: has_output_compound UPa:UPC04409 ! 2-amino-3-carboxymuconate semialdehyde
relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde
relationship: part_of UPa:UER00330 {cardinality="1", direction="RL", order="2"} ! quinolinate from L-kynurenine: step 3/3
relationship: part_of UPa:UER00330 ! quinolinate from L-kynurenine: step 3/3

[Term]
id: UPa:UCR04296
name: (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = UDP + dhurrin
namespace: reaction
xref: KEGG:R04296 "KEGG reaction"
xref: METACYC:RXN-743 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12856 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose
relationship: has_input_compound UPa:UPC00029 ! UDP-alpha-D-glucose
relationship: has_input_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile
relationship: has_input_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile
relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP
relationship: has_output_compound UPa:UPC00015 ! UDP
relationship: has_output_compound UPa:UPC05143 {cardinality="1"} ! dhurrin
relationship: has_output_compound UPa:UPC05143 ! dhurrin
relationship: part_of UPa:UER00746 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 3/3
relationship: part_of UPa:UER00746 ! dhurrin from L-tyrosine: step 3/3

[Term]
id: UPa:UCR04325
name: 10-formyl-5,6,7,8-tetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = 5,6,7,8-tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
namespace: reaction
xref: KEGG:R04325 "KEGG reaction"
xref: METACYC:GART-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15056 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: part_of UPa:UER00126 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1
relationship: part_of UPa:UER00126 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1

[Term]
id: UPa:UCR04336
name: (S)-2-amino-6-oxopimelate = (S)-tetrahydrodipicolinate + H(2)O
namespace: reaction
xref: KEGG:R04336 "KEGG reaction"
xref: METACYC:RXN-4821 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24800 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03871 ! (S)-2-amino-6-oxopimelate
relationship: has_input_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate
relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="1"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1
relationship: part_of UPa:UER00026 ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1

[Term]
id: UPa:UCR04347
name: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M
namespace: reaction
xref: KEGG:R04347 "KEGG reaction"
xref: METACYC:2.1.1.86-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17588 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M
relationship: has_input_compound UPa:UPC03576 ! coenzyme M
relationship: has_input_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC01217 ! 5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC03920 ! methyl-coenzyme M
relationship: has_output_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M
relationship: part_of UPa:UER00698 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2
relationship: part_of UPa:UER00698 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2

[Term]
id: UPa:UCR04364
name: (S)-tetrahydrodipicolinate + H(2)O + acetyl-CoA = (S)-2-acetamido-6-oxopimelate + CoA
namespace: reaction
xref: KEGG:R04364 "KEGG reaction"
xref: METACYC:2.3.1.89-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13088 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate
relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate
relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate
relationship: part_of UPa:UER00022 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3
relationship: part_of UPa:UER00022 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3

[Term]
id: UPa:UCR04365
name: (S)-tetrahydrodipicolinate + H(2)O + succinyl-CoA = CoA + L-2-succinylamino-6-oxopimelate
namespace: reaction
xref: KEGG:R04365 "KEGG reaction"
xref: METACYC:TETHYDPICSUCC-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17328 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00091 ! succinyl-CoA
relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA
relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate
relationship: has_input_compound UPa:UPC03972 ! (S)-tetrahydrodipicolinate
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate
relationship: has_output_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate
relationship: part_of UPa:UER00019 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3
relationship: part_of UPa:UER00019 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3

[Term]
id: UPa:UCR04371
name: homoisocitrate = H(2)O + homo-cis-aconitate
namespace: reaction
xref: KEGG:R04371 "KEGG reaction"
xref: METACYC:HOMOACONITATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15488 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05662 ! homoisocitrate
relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC04002 ! homo-cis-aconitate
relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate
relationship: part_of UPa:UER01027 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 3/5
relationship: part_of UPa:UER01027 ! L-alpha-aminoadipate from 2-oxoglutarate: step 3/5

[Term]
id: UPa:UCR04376
name: 3-(2,3-dihydroxyphenyl)propanoate + O(2) = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate
namespace: reaction
xref: KEGG:R04376 "KEGG reaction"
xref: METACYC:1.13.11.16-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23843 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: has_input_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: has_output_compound UPa:UPC04479 ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate
relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate
relationship: part_of UPa:UER00794 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4
relationship: part_of UPa:UER00794 ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4

[Term]
id: UPa:UCR04379
name: 5-carboxymethyl-2-hydroxymuconic acid = 5-oxopent-3-ene-1,2,5-tricarboxylic acid
namespace: reaction
xref: KEGG:R04379 "KEGG reaction"
xref: METACYC:5.3.3.10-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18816 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid
relationship: has_input_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid
relationship: has_output_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid
relationship: has_output_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid
relationship: part_of UPa:UER00419 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7
relationship: part_of UPa:UER00419 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7

[Term]
id: UPa:UCR04380
name: 5-oxopent-3-ene-1,2,5-tricarboxylic acid = 2-hydroxy-hept-2,4-diene-1,7-dioic acid + CO(2)
namespace: reaction
xref: KEGG:R04380 "KEGG reaction"
xref: METACYC:CARBOXY-OXOHEPT-ENEDIOATE-DECARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid
relationship: has_input_compound UPa:UPC04052 ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid
relationship: has_output_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid
relationship: part_of UPa:UER00420 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7
relationship: part_of UPa:UER00420 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7

[Term]
id: UPa:UCR04382
name: 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid = 2 5-dehydro-4-deoxy-D-glucuronic acid
namespace: reaction
xref: KEGG:R04382 "KEGG reaction"
xref: METACYC:OLIGOGALACTURONIDE-LYASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:20272 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06118 ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid
relationship: has_input_compound UPa:UPC06118 {cardinality="1"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid
relationship: has_output_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid
relationship: has_output_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid
relationship: part_of UPa:UER00825 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5
relationship: part_of UPa:UER00825 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5

[Term]
id: UPa:UCR04383
name: 5-dehydro-4-deoxy-D-glucuronic acid = 3-deoxy-D-glycero-hexo-2,5-diulosonate
namespace: reaction
xref: KEGG:R04383 "KEGG reaction"
xref: METACYC:5.3.1.17-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23899 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid
relationship: has_input_compound UPa:UPC04053 ! 5-dehydro-4-deoxy-D-glucuronic acid
relationship: has_output_compound UPa:UPC04349 ! 3-deoxy-D-glycero-hexo-2,5-diulosonate
relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate
relationship: part_of UPa:UER00826 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5
relationship: part_of UPa:UER00826 ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5

[Term]
id: UPa:UCR04390
name: H(+) + NADPH + alpha-aminoadipoyl-S-acyl enzyme = L-2-aminoadipate 6-semialdahyde + NADP(+) + holo-Lys2
namespace: reaction
xref: KEGG:R04390 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme
relationship: has_input_compound UPa:UPC05535 ! alpha-aminoadipoyl-S-acyl enzyme
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC04076 ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde
relationship: has_output_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2
relationship: has_output_compound UPa:UPC11482 ! holo-Lys2
relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="3"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3
relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3

[Term]
id: UPa:UCR04393
name: lactose + protein N(pi)-phospho-L-histidine = lactose 6-phosphate + protein-L-histidine
namespace: reaction
xref: KEGG:R04393 "KEGG reaction"
xref: RHEA:42403 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00243 {cardinality="1"} ! lactose
relationship: has_input_compound UPa:UPC00243 ! lactose
relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine
relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine
relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine
relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine
relationship: has_output_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate
relationship: has_output_compound UPa:UPC05396 ! lactose 6-phosphate
relationship: part_of UPa:UER00604 {cardinality="1", direction="LR", order="1"} ! lactose 6-phosphate from lactose (PTS route): step 1/1
relationship: part_of UPa:UER00604 ! lactose 6-phosphate from lactose (PTS route): step 1/1

[Term]
id: UPa:UCR04405
name: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate
namespace: reaction
xref: KEGG:R04405 "KEGG reaction"
xref: METACYC:HOMOCYSMET-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21199 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00155 ! L-homocysteine
relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine
relationship: has_input_compound UPa:UPC04489 ! 5-methyltetrahydropteroyltri-L-glutamate
relationship: has_input_compound UPa:UPC04489 {cardinality="1"} ! 5-methyltetrahydropteroyltri-L-glutamate
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC04144 {cardinality="1"} ! tetrahydropteroyltri-L-glutamate
relationship: has_output_compound UPa:UPC04144 ! tetrahydropteroyltri-L-glutamate
relationship: part_of UPa:UER00082 ! L-methionine from L-homocysteine (MetE route): step 1/1
relationship: part_of UPa:UER00082 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetE route): step 1/1

[Term]
id: UPa:UCR04418
name: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 5-carboxymethyl-2-hydroxymuconic acid + H(+) + NADH
namespace: reaction
xref: KEGG:R04418 "KEGG reaction"
xref: METACYC:CHMS-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15684 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC04642 ! 5-carboxymethyl-2-hydroxymuconate semialdehyde
relationship: has_input_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04186 ! 5-carboxymethyl-2-hydroxymuconic acid
relationship: has_output_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid
relationship: part_of UPa:UER00418 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7
relationship: part_of UPa:UER00418 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7

[Term]
id: UPa:UCR04420
name: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
namespace: reaction
xref: KEGG:R04420 "KEGG reaction"
xref: METACYC:5.3.1.23-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19992 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04188 ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: has_input_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate
relationship: has_output_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate
relationship: part_of UPa:UER00874 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6
relationship: part_of UPa:UER00874 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6

[Term]
id: UPa:UCR04426
name: (2R,3S)-3-isopropylmalate + NAD(+) = 3-carboxy-4-methyl-2-oxopentanoate + H(+) + NADH
namespace: reaction
xref: KEGG:R04426 "KEGG reaction"
xref: METACYC:3-ISOPROPYLMALDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10895 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate
relationship: has_input_compound UPa:UPC04411 ! (2R,3S)-3-isopropylmalate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC04236 ! 3-carboxy-4-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate
relationship: part_of UPa:UER00072 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4
relationship: part_of UPa:UER00072 ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4

[Term]
id: UPa:UCR04427
name: S-adenosyl-L-methionine + zymosterol = S-adenosyl-L-homocysteine + fecosterol
namespace: reaction
xref: KEGG:R04427 "KEGG reaction"
xref: METACYC:RXN3O-178 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21131 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC05437 ! zymosterol
relationship: has_input_compound UPa:UPC05437 {cardinality="1"} ! zymosterol
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC04525 ! fecosterol
relationship: has_output_compound UPa:UPC04525 {cardinality="1"} ! fecosterol
relationship: part_of UPa:UER00760 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 1/5
relationship: part_of UPa:UER00760 ! ergosterol from zymosterol: step 1/5

[Term]
id: UPa:UCR04440
name: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 2-oxo-3-hydroxyisovalerate + H(+) + NADPH
namespace: reaction
xref: KEGG:R04440 "KEGG reaction"
xref: RHEA:31142 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate
relationship: has_input_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate
relationship: has_output_compound UPa:UPC04181 ! 2-oxo-3-hydroxyisovalerate
relationship: part_of UPa:UER00060 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 2/4
relationship: part_of UPa:UER00060 ! L-valine from pyruvate: step 2/4

[Term]
id: UPa:UCR04441
name: (R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O
namespace: reaction
xref: KEGG:R04441 "KEGG reaction"
xref: METACYC:DIHYDROXYISOVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24812 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04272 ! (R)-2,3-dihydroxy-3-methylbutanoate
relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00141 ! 3-methyl-2-oxobutanoate
relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate
relationship: part_of UPa:UER00061 ! L-valine from pyruvate: step 3/4
relationship: part_of UPa:UER00061 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 3/4

[Term]
id: UPa:UCR04448
name: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP
namespace: reaction
xref: KEGG:R04448 "KEGG reaction"
xref: METACYC:THIAZOLSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24215 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC04294 ! 5-(2-hydroxyethyl)-4-methylthiazole
relationship: has_input_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole
relationship: has_output_compound UPa:UPC04327 ! 4-methyl-5-(2-phosphoethyl)-thiazole
relationship: part_of UPa:UER00139 ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1
relationship: part_of UPa:UER00139 {cardinality="1", direction="LR", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1

[Term]
id: UPa:UCR04455
name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylene-5,6,7,8-tetrahydromethanopterin + H(+)
namespace: reaction
xref: KEGG:R04455 "KEGG reaction"
xref: METACYC:H2-METHYLENE-THMPT-DEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20020 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00282 ! H(2)
relationship: has_input_compound UPa:UPC00282 {cardinality="1"} ! H(2)
relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: part_of UPa:UER00696 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1
relationship: part_of UPa:UER00696 {cardinality="1", direction="LR", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1

[Term]
id: UPa:UCR04456
name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin + coenzyme F420 = 1,5-dihydro-coenzyme F(420) + 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
namespace: reaction
xref: KEGG:R04456 "KEGG reaction"
xref: METACYC:1.5.99.9-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16724 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420
relationship: has_input_compound UPa:UPC00876 ! coenzyme F420
relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420)
relationship: has_output_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420)
relationship: has_output_compound UPa:UPC04330 ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
relationship: part_of UPa:UER00695 {cardinality="1", direction="RL", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1
relationship: part_of UPa:UER00695 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1

[Term]
id: UPa:UCR04457
name: 2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H(2)O + phosphate
namespace: reaction
xref: KEGG:R04457 "KEGG reaction"
xref: METACYC:LUMAZINESYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:26155 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil
relationship: has_input_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil
relationship: has_input_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate
relationship: has_input_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC04332 ! 6,7-dimethyl-8-(1-D-ribityl)lumazine
relationship: has_output_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine
relationship: part_of UPa:UER00404 ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2
relationship: part_of UPa:UER00404 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2

[Term]
id: UPa:UCR04463
name: ATP + H(2)O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + L-glutamate + phosphate
namespace: reaction
xref: KEGG:R04463 "KEGG reaction"
xref: METACYC:FGAMSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17132 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_input_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine
relationship: has_output_compound UPa:UPC04640 ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine
relationship: part_of UPa:UER00128 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2
relationship: part_of UPa:UER00128 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2

[Term]
id: UPa:UCR04464
name: 1,5-dihydro-coenzyme F(420) + 5,10-methylene-5,6,7,8-tetrahydromethanopterin = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420
namespace: reaction
xref: KEGG:R04464 "KEGG reaction"
xref: METACYC:METHELENE-THMPT-OXI-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:21147 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420)
relationship: has_input_compound UPa:UPC01080 ! 1,5-dihydro-coenzyme F(420)
relationship: has_input_compound UPa:UPC04377 ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC00876 ! coenzyme F420
relationship: has_output_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420
relationship: has_output_compound UPa:UPC04488 ! 5-methyl-5,6,7,8-tetrahydromethanopterin
relationship: has_output_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin
relationship: part_of UPa:UER00697 ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2
relationship: part_of UPa:UER00697 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2

[Term]
id: UPa:UCR04467
name: 2-oxoglutarate + N-acetyl-LL-2,6-diaminopimelate = (S)-2-acetamido-6-oxopimelate + L-glutamate
namespace: reaction
xref: KEGG:R04467 "KEGG reaction"
xref: METACYC:RXN-4822 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25318 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC04390 ! N-acetyl-LL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC05539 ! (S)-2-acetamido-6-oxopimelate
relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate
relationship: part_of UPa:UER00023 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3
relationship: part_of UPa:UER00023 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3

[Term]
id: UPa:UCR04475
name: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate
namespace: reaction
xref: KEGG:R04475 "KEGG reaction"
xref: METACYC:SUCCINYLDIAMINOPIMTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11963 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate
relationship: has_input_compound UPa:UPC04421 ! N-succinyl-LL-2,6-diaminopimelate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC04462 ! L-2-succinylamino-6-oxopimelate
relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate
relationship: part_of UPa:UER00020 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3
relationship: part_of UPa:UER00020 ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3

[Term]
id: UPa:UCR04509
name: 4-amino-2-methyl-5-phosphomethylpyrimidine + ATP = 4-amino-2-methyl-5-diphosphomethylpyrimidine + ADP
namespace: reaction
xref: KEGG:R04509 "KEGG reaction"
xref: METACYC:PYRIMSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19896 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine
relationship: has_input_compound UPa:UPC04556 ! 4-amino-2-methyl-5-phosphomethylpyrimidine
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine
relationship: has_output_compound UPa:UPC04752 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine
relationship: part_of UPa:UER00138 ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3
relationship: part_of UPa:UER00138 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3

[Term]
id: UPa:UCR04540
name: coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine
namespace: reaction
xref: KEGG:R04540 "KEGG reaction"
xref: METACYC:1.8.98.1-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:18088 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide
relationship: has_input_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide
relationship: has_input_compound UPa:UPC11904 {cardinality="1"} ! dihydromethanophenazine
relationship: has_input_compound UPa:UPC11904 ! dihydromethanophenazine
relationship: has_output_compound UPa:UPC03576 ! coenzyme M
relationship: has_output_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M
relationship: has_output_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B
relationship: has_output_compound UPa:UPC04628 ! coenzyme B
relationship: has_output_compound UPa:UPC11903 {cardinality="1"} ! methanophenazine
relationship: has_output_compound UPa:UPC11903 ! methanophenazine
relationship: part_of UPa:UER00700 {cardinality="1", direction="LR", order="1"} ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1
relationship: part_of UPa:UER00700 ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1

[Term]
id: UPa:UCR04541
name: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane
namespace: reaction
xref: KEGG:R04541 "KEGG reaction"
xref: METACYC:METHYL-COM-HTP-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12535 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M
relationship: has_input_compound UPa:UPC03920 ! methyl-coenzyme M
relationship: has_input_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B
relationship: has_input_compound UPa:UPC04628 ! coenzyme B
relationship: has_output_compound UPa:UPC01438 {cardinality="1"} ! methane
relationship: has_output_compound UPa:UPC01438 ! methane
relationship: has_output_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide
relationship: has_output_compound UPa:UPC04832 ! coenzyme M-coenzyme B heterodisulfide
relationship: part_of UPa:UER00699 {cardinality="1", direction="LR", order="1"} ! methane from methyl-coenzyme M: step 1/1
relationship: part_of UPa:UER00699 ! methane from methyl-coenzyme M: step 1/1

[Term]
id: UPa:UCR04549
name: H(2)O + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = UMP + lipid X
namespace: reaction
xref: KEGG:R04549 "KEGG reaction"
xref: METACYC:LIPIDXSYNTHESIS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25216 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_output_compound UPa:UPC00105 ! UMP
relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP
relationship: has_output_compound UPa:UPC04824 ! lipid X
relationship: has_output_compound UPa:UPC04824 {cardinality="1"} ! lipid X
relationship: part_of UPa:UER00480 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6
relationship: part_of UPa:UER00480 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6

[Term]
id: UPa:UCR04550
name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine = UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + acyl-carrier protein
namespace: reaction
xref: KEGG:R04550 "KEGG reaction"
xref: RHEA:17820 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]
relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]
relationship: has_input_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_input_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein
relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein
relationship: has_output_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_output_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: part_of UPa:UER00479 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6
relationship: part_of UPa:UER00479 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6

[Term]
id: UPa:UCR04558
name: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate
namespace: reaction
xref: KEGG:R04558 "KEGG reaction"
xref: METACYC:GLUTAMIDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24796 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
relationship: has_input_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC04666 ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
relationship: has_output_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00010 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9
relationship: part_of UPa:UER00010 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9
relationship: part_of UPa:UER00899 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1
relationship: part_of UPa:UER00899 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1

[Term]
id: UPa:UCR04559
name: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate
namespace: reaction
xref: KEGG:R04559 "KEGG reaction"
xref: METACYC:AICARSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23923 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid
relationship: has_input_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid
relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate
relationship: has_output_compound UPa:UPC00122 ! fumarate
relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00132 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2
relationship: part_of UPa:UER00132 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2

[Term]
id: UPa:UCR04560
name: 10-formyl-5,6,7,8-tetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
namespace: reaction
xref: KEGG:R04560 "KEGG reaction"
xref: METACYC:AICARTRANSFORM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22195 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00234 ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate
relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC00101 ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate
relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00133 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1
relationship: part_of UPa:UER00133 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1

[Term]
id: UPa:UCR04567
name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + acyl-carrier protein
namespace: reaction
xref: KEGG:R04567 "KEGG reaction"
xref: RHEA:13928 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine
relationship: has_input_compound UPa:UPC00043 ! UDP-N-acetyl-alpha-D-glucosamine
relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]
relationship: has_input_compound UPa:UPC04688 ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]
relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein
relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein
relationship: has_output_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
relationship: has_output_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
relationship: part_of UPa:UER00477 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6
relationship: part_of UPa:UER00477 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6

[Term]
id: UPa:UCR04587
name: H(2)O + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + acetate
namespace: reaction
xref: KEGG:R04587 "KEGG reaction"
xref: METACYC:UDPACYLGLCNACDEACETYL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25212 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
relationship: has_input_compound UPa:UPC04738 ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_output_compound UPa:UPC00033 ! acetate
relationship: has_output_compound UPa:UPC06022 ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_output_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
relationship: part_of UPa:UER00478 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6
relationship: part_of UPa:UER00478 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6

[Term]
id: UPa:UCR04591
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid + ADP + phosphate
namespace: reaction
xref: KEGG:R04591 "KEGG reaction"
xref: METACYC:SAICARSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22631 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: has_input_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC04823 ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid
relationship: has_output_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid
relationship: part_of UPa:UER00131 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2
relationship: part_of UPa:UER00131 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2

[Term]
id: UPa:UCR04594
name: H(2)O + alpha-ribazole 5'-phosphate = alpha-ribazole + phosphate
namespace: reaction
xref: KEGG:R04594 "KEGG reaction"
xref: METACYC:RIBAZOLEPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24459 "Rhea reaction"
xref: RHEA:30370 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC04778 ! alpha-ribazole 5'-phosphate
relationship: has_input_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole
relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole
relationship: part_of UPa:UER00517 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2
relationship: part_of UPa:UER00517 ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2

[Term]
id: UPa:UCR04606
name: UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + lipid X = 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + UDP
namespace: reaction
xref: KEGG:R04606 "KEGG reaction"
xref: METACYC:LIPIDADISACCHARIDESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22671 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_input_compound UPa:UPC04652 ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine
relationship: has_input_compound UPa:UPC04824 {cardinality="1"} ! lipid X
relationship: has_input_compound UPa:UPC04824 ! lipid X
relationship: has_output_compound UPa:UPC00015 ! UDP
relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP
relationship: has_output_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate
relationship: part_of UPa:UER00481 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6
relationship: part_of UPa:UER00481 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6

[Term]
id: UPa:UCR04621
name: 7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H(2)O
namespace: reaction
xref: KEGG:R04621 "KEGG reaction"
xref: METACYC:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25309 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC04874 ! 7,8-dihydroneopterin
relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate
relationship: has_output_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate
relationship: part_of UPa:UER00153 {cardinality="1", direction="RL", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4
relationship: part_of UPa:UER00153 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4

[Term]
id: UPa:UCR04638
name: 7,8-dihydroneopterin triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate
namespace: reaction
xref: KEGG:R04638 "KEGG reaction"
xref: METACYC:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25305 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate
relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC05925 ! 7,8-dihydroneopterin 3'-phosphate
relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate
relationship: part_of UPa:UER00152 ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4
relationship: part_of UPa:UER00152 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4

[Term]
id: UPa:UCR04639
name: 7,8-dihydroneopterin triphosphate + H(2)O = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
namespace: reaction
xref: KEGG:R04639 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate
relationship: has_input_compound UPa:UPC04895 ! 7,8-dihydroneopterin triphosphate
relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
relationship: has_output_compound UPa:UPC06148 ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
relationship: part_of UPa:UER00151 {cardinality="1", direction="RL", order="4"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1
relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1

[Term]
id: UPa:UCR04640
name: 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide = 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
namespace: reaction
xref: KEGG:R04640 "KEGG reaction"
xref: METACYC:PRIBFAICARPISOM-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15472 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
relationship: has_input_compound UPa:UPC04896 ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04916 ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00009 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9
relationship: part_of UPa:UER00009 ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9

[Term]
id: UPa:UCR04657
name: 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + ATP = ADP + lipid IV(A)
namespace: reaction
xref: KEGG:R04657 "KEGG reaction"
xref: METACYC:TETRAACYLDISACC4KIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20703 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate
relationship: has_input_compound UPa:UPC04932 ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A)
relationship: has_output_compound UPa:UPC04919 ! lipid IV(A)
relationship: part_of UPa:UER00482 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6
relationship: part_of UPa:UER00482 ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6

[Term]
id: UPa:UCR04658
name: CMP-3-deoxy-D-manno-octulosonate + lipid IV(A) = 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP
namespace: reaction
xref: KEGG:R04658 "KEGG reaction"
xref: METACYC:KDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28069 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A)
relationship: has_input_compound UPa:UPC04919 ! lipid IV(A)
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A))
relationship: has_output_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A))
relationship: part_of UPa:UER00483 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4
relationship: part_of UPa:UER00483 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4

[Term]
id: UPa:UCR04672
name: (S)-2-acetolactate + thiamine diphosphate = 2-hydroxyethyl-ThPP + pyruvate
namespace: reaction
xref: KEGG:R04672 "KEGG reaction"
xref: METACYC:RXN-14037 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24808 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate
relationship: has_input_compound UPa:UPC00068 ! thiamine diphosphate
relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate
relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP
relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP
relationship: part_of UPa:UER00059 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 1/4
relationship: part_of UPa:UER00059 ! L-valine from pyruvate: step 1/4

[Term]
id: UPa:UCR04673
name: 2-hydroxyethyl-ThPP + 2-oxobutanoate = (S)-2-acetyl-2-hydroxybutanoic acid + thiamine diphosphate
namespace: reaction
xref: KEGG:R04673 "KEGG reaction"
xref: RHEA:33694 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate
relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate
relationship: has_input_compound UPa:UPC05125 ! 2-hydroxyethyl-ThPP
relationship: has_input_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP
relationship: has_output_compound UPa:UPC00068 ! thiamine diphosphate
relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate
relationship: has_output_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid
relationship: has_output_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid
relationship: part_of UPa:UER00055 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 1/4
relationship: part_of UPa:UER00055 ! L-isoleucine from 2-oxobutanoate: step 1/4

[Term]
id: UPa:UCR04692
name: (S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R04692 "KEGG reaction"
xref: METACYC:2.1.1.140-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17412 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC06161 ! (S)-coclaurine
relationship: has_input_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05176 ! (S)-N-methylcoclaurine
relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine
relationship: part_of UPa:UER00442 ! (S)-reticuline from (S)-norcoclaurine: step 2/4
relationship: part_of UPa:UER00442 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 2/4

[Term]
id: UPa:UCR04694
name: 2 H(2)O + NADP(+) + berbamunine = (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + H(+) + NADPH + O(2)
namespace: reaction
xref: KEGG:R04694 "KEGG reaction"
xref: METACYC:1.1.3.34-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23579 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC05177 ! berbamunine
relationship: has_input_compound UPa:UPC05177 {cardinality="1"} ! berbamunine
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00007 ! O(2)
relationship: has_output_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05176 ! (S)-N-methylcoclaurine
relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine
relationship: has_output_compound UPa:UPC05243 {cardinality="1"} ! (R)-N-methylcoclaurine
relationship: has_output_compound UPa:UPC05243 ! (R)-N-methylcoclaurine
relationship: part_of UPa:UER00446 {cardinality="1", direction="RL", order="1"} ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1
relationship: part_of UPa:UER00446 ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1

[Term]
id: UPa:UCR04862
name: NAD(+) + homoisocitrate = 2-oxaloglutaric acid + H(+) + NADH
namespace: reaction
xref: KEGG:R04862 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC05662 ! homoisocitrate
relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid
relationship: has_output_compound UPa:UPC05533 ! 2-oxaloglutaric acid
relationship: part_of UPa:UER00030 ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5
relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5

[Term]
id: UPa:UCR04863
name: alpha-aminoadipoyl-C6-AMP + holo-Lys2 = AMP + alpha-aminoadipoyl-S-acyl enzyme
namespace: reaction
xref: KEGG:R04863 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP
relationship: has_input_compound UPa:UPC05560 ! alpha-aminoadipoyl-C6-AMP
relationship: has_input_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2
relationship: has_input_compound UPa:UPC11482 ! holo-Lys2
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme
relationship: has_output_compound UPa:UPC05535 ! alpha-aminoadipoyl-S-acyl enzyme
relationship: part_of UPa:UER00032 ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3
relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="2"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3

[Term]
id: UPa:UCR04868
name: H(2)O + isopenicillin N + phenylacetyl-CoA = CoA + L-alpha-aminoadipate + penicillin G
namespace: reaction
xref: KEGG:R04868 "KEGG reaction"
xref: METACYC:2.3.1.164-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20723 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00582 ! phenylacetyl-CoA
relationship: has_input_compound UPa:UPC00582 {cardinality="1"} ! phenylacetyl-CoA
relationship: has_input_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N
relationship: has_input_compound UPa:UPC05557 ! isopenicillin N
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC05551 {cardinality="1"} ! penicillin G
relationship: has_output_compound UPa:UPC05551 ! penicillin G
relationship: part_of UPa:UER00241 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3
relationship: part_of UPa:UER00241 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3

[Term]
id: UPa:UCR04870
name: 3 ATP + H(2)O + L-alpha-aminoadipate + L-cysteine + L-valine = 3 AMP + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 diphosphate
namespace: reaction
xref: KEGG:R04870 "KEGG reaction"
xref: METACYC:6.3.2.26-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23199 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00097 ! L-cysteine
relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine
relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine
relationship: has_input_compound UPa:UPC00183 ! L-valine
relationship: has_input_compound UPa:UPC00956 ! L-alpha-aminoadipate
relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
relationship: has_output_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
relationship: part_of UPa:UER00239 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3
relationship: part_of UPa:UER00239 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3

[Term]
id: UPa:UCR04872
name: N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N
namespace: reaction
xref: KEGG:R04872 "KEGG reaction"
xref: METACYC:1.21.3.1-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22431 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC05556 ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
relationship: has_input_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC05557 ! isopenicillin N
relationship: has_output_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N
relationship: part_of UPa:UER00240 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3
relationship: part_of UPa:UER00240 ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3

[Term]
id: UPa:UCR05046
name: H(2)O + formamidopyrimidine nucleoside triphosphate = 2,5-diaminopyrimidine nucleoside triphosphate + formate
namespace: reaction
xref: KEGG:R05046 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate
relationship: has_input_compound UPa:UPC05922 ! formamidopyrimidine nucleoside triphosphate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate
relationship: has_output_compound UPa:UPC05923 ! 2,5-diaminopyrimidine nucleoside triphosphate
relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1
relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="2"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1

[Term]
id: UPa:UCR05048
name: 2,5-diaminopyrimidine nucleoside triphosphate = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
namespace: reaction
xref: KEGG:R05048 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate
relationship: has_input_compound UPa:UPC05923 ! 2,5-diaminopyrimidine nucleoside triphosphate
relationship: has_output_compound UPa:UPC06148 ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
relationship: part_of UPa:UER00151 ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1
relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="3"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1

[Term]
id: UPa:UCR05049
name: H(2)O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = H(+) + N(2)-succinyl-L-glutamic acid + NADH
namespace: reaction
xref: KEGG:R05049 "KEGG reaction"
xref: METACYC:SUCCGLUALDDEHYD-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10815 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde
relationship: has_input_compound UPa:UPC05932 ! N-succinyl-L-glutamate 5-semialdehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid
relationship: has_output_compound UPa:UPC05931 ! N(2)-succinyl-L-glutamic acid
relationship: part_of UPa:UER00282 ! L-glutamate and succinate from L-arginine: step 4/5
relationship: part_of UPa:UER00282 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 4/5

[Term]
id: UPa:UCR05068
name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid + NADP(+) = (R)-3-hydroxy-3-methyl-2-oxopentanoate + H(+) + NADPH
namespace: reaction
xref: KEGG:R05068 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC14463 ! (R)-3-hydroxy-3-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate
relationship: part_of UPa:UER00056 {cardinality="1", direction="RL", order="2"} ! L-isoleucine from 2-oxobutanoate: step 2/4
relationship: part_of UPa:UER00056 ! L-isoleucine from 2-oxobutanoate: step 2/4

[Term]
id: UPa:UCR05069
name: (S)-2-acetyl-2-hydroxybutanoic acid = (R)-3-hydroxy-3-methyl-2-oxopentanoate
namespace: reaction
xref: KEGG:R05069 "KEGG reaction"
xref: RHEA:25407 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06006 ! (S)-2-acetyl-2-hydroxybutanoic acid
relationship: has_input_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid
relationship: has_output_compound UPa:UPC14463 ! (R)-3-hydroxy-3-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate
relationship: part_of UPa:UER00056 ! L-isoleucine from 2-oxobutanoate: step 2/4
relationship: part_of UPa:UER00056 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 2/4

[Term]
id: UPa:UCR05070
name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid = (S)-3-methyl-2-oxopentanoate + H(2)O
namespace: reaction
xref: KEGG:R05070 "KEGG reaction"
xref: METACYC:DIHYDROXYMETVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:27697 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06007 ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00671 ! (S)-3-methyl-2-oxopentanoate
relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate
relationship: part_of UPa:UER00057 ! L-isoleucine from 2-oxobutanoate: step 3/4
relationship: part_of UPa:UER00057 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 3/4

[Term]
id: UPa:UCR05071
name: (S)-2-acetolactate = 2-oxo-3-hydroxyisovalerate
namespace: reaction
xref: KEGG:R05071 "KEGG reaction"
xref: METACYC:2-ACETOLACTATE-MUTASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:31258 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06010 ! (S)-2-acetolactate
relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate
relationship: has_output_compound UPa:UPC04181 ! 2-oxo-3-hydroxyisovalerate
relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate
relationship: part_of UPa:UER00060 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 2/4
relationship: part_of UPa:UER00060 ! L-valine from pyruvate: step 2/4

[Term]
id: UPa:UCR05074
name: 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP-3-deoxy-D-manno-octulosonate = CMP + di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
namespace: reaction
xref: KEGG:R05074 "KEGG reaction"
xref: METACYC:KDOTRANS2-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28065 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04121 ! CMP-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate
relationship: has_input_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A))
relationship: has_input_compound UPa:UPC06024 ! 3-deoxy-D-manno-octulosonyl-lipid IV((A))
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
relationship: has_output_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
relationship: part_of UPa:UER00484 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4
relationship: part_of UPa:UER00484 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4

[Term]
id: UPa:UCR05075
name: lauroyl-KDO(2)-lipid IV(A) + tetradecanoyl-[acp] = KDO(2)-lipid A + acyl-carrier protein
namespace: reaction
xref: KEGG:R05075 "KEGG reaction"
xref: RHEA:28441 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05761 {cardinality="1"} ! tetradecanoyl-[acp]
relationship: has_input_compound UPa:UPC05761 ! tetradecanoyl-[acp]
relationship: has_input_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A)
relationship: has_input_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A)
relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein
relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein
relationship: has_output_compound UPa:UPC06026 ! KDO(2)-lipid A
relationship: has_output_compound UPa:UPC06026 {cardinality="1"} ! KDO(2)-lipid A
relationship: part_of UPa:UER00486 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4
relationship: part_of UPa:UER00486 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4

[Term]
id: UPa:UCR05085
name: 2-oxoglutarate + 4-(phosphonooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + L-glutamate
namespace: reaction
xref: KEGG:R05085 "KEGG reaction"
xref: METACYC:PSERTRANSAMPYR-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16576 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine
relationship: has_input_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid
relationship: has_output_compound UPa:UPC06054 ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid
relationship: part_of UPa:UER00311 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5
relationship: part_of UPa:UER00311 {cardinality="1", direction="RL", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5

[Term]
id: UPa:UCR05123
name: (S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R05123 "KEGG reaction"
xref: METACYC:2.1.1.128-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:31910 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC06160 ! (S)-norcoclaurine
relationship: has_input_compound UPa:UPC06160 {cardinality="1"} ! (S)-norcoclaurine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC06161 ! (S)-coclaurine
relationship: has_output_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine
relationship: part_of UPa:UER00441 ! (S)-reticuline from (S)-norcoclaurine: step 1/4
relationship: part_of UPa:UER00441 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 1/4

[Term]
id: UPa:UCR05146
name: di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + dodecanoyl-[acyl-carrier protein] = acyl-carrier protein + lauroyl-KDO(2)-lipid IV(A)
namespace: reaction
xref: KEGG:R05146 "KEGG reaction"
xref: RHEA:28445 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05223 ! dodecanoyl-[acyl-carrier protein]
relationship: has_input_compound UPa:UPC05223 {cardinality="1"} ! dodecanoyl-[acyl-carrier protein]
relationship: has_input_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
relationship: has_input_compound UPa:UPC06025 ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
relationship: has_output_compound UPa:UPC00229 ! acyl-carrier protein
relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein
relationship: has_output_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A)
relationship: has_output_compound UPa:UPC06251 ! lauroyl-KDO(2)-lipid IV(A)
relationship: part_of UPa:UER00485 ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4
relationship: part_of UPa:UER00485 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4

[Term]
id: UPa:UCR05149
name: 2 S-adenosyl-L-methionine + precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + precorrin-8X
namespace: reaction
xref: KEGG:R05149 "KEGG reaction"
xref: METACYC:2.1.1.132-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17480 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B
relationship: has_input_compound UPa:UPC06319 ! precorrin-6B
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X
relationship: has_output_compound UPa:UPC06408 ! precorrin-8X
relationship: part_of UPa:UER00218 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10
relationship: part_of UPa:UER00218 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10

[Term]
id: UPa:UCR05150
name: NADP(+) + precorrin-6B = H(+) + NADPH + precorrin-6A
namespace: reaction
xref: KEGG:R05150 "KEGG reaction"
xref: METACYC:1.3.1.54-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23411 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B
relationship: has_input_compound UPa:UPC06319 ! precorrin-6B
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A
relationship: has_output_compound UPa:UPC06320 ! precorrin-6A
relationship: part_of UPa:UER00217 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10
relationship: part_of UPa:UER00217 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10

[Term]
id: UPa:UCR05176
name: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
namespace: reaction
xref: KEGG:R05176 "KEGG reaction"
xref: METACYC:5.1.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17580 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose
relationship: has_input_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose
relationship: has_output_compound UPa:UPC06398 {cardinality="1"} ! ADP-L-glycero-beta-D-manno-heptose
relationship: has_output_compound UPa:UPC06398 ! ADP-L-glycero-beta-D-manno-heptose
relationship: part_of UPa:UER00440 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4
relationship: part_of UPa:UER00440 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4

[Term]
id: UPa:UCR05177
name: precorrin-8X = hydrogenobyrinic acid
namespace: reaction
xref: KEGG:R05177 "KEGG reaction"
xref: METACYC:5.4.1.2-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22515 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06408 ! precorrin-8X
relationship: has_input_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X
relationship: has_output_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid
relationship: has_output_compound UPa:UPC06399 ! hydrogenobyrinic acid
relationship: part_of UPa:UER00219 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10
relationship: part_of UPa:UER00219 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10

[Term]
id: UPa:UCR05180
name: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4
namespace: reaction
xref: KEGG:R05180 "KEGG reaction"
xref: METACYC:2.1.1.131-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12764 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC06406 ! precorrin-3B
relationship: has_input_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC06407 ! precorrin-4
relationship: has_output_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4
relationship: part_of UPa:UER00214 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10
relationship: part_of UPa:UER00214 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10

[Term]
id: UPa:UCR05181
name: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
namespace: reaction
xref: KEGG:R05181 "KEGG reaction"
xref: METACYC:2.1.1.133-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22015 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC06407 ! precorrin-4
relationship: has_input_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC06416 ! precorrin-5
relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5
relationship: part_of UPa:UER00215 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10
relationship: part_of UPa:UER00215 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10

[Term]
id: UPa:UCR05217
name: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B
namespace: reaction
xref: KEGG:R05217 "KEGG reaction"
xref: METACYC:R321-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17296 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A
relationship: has_input_compound UPa:UPC05772 ! precorrin-3A
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC06406 ! precorrin-3B
relationship: has_output_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B
relationship: part_of UPa:UER00213 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10
relationship: part_of UPa:UER00213 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10

[Term]
id: UPa:UCR05218
name: FMNH(2) + 2 cob(II)yrinate a,c-diamide = FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide
namespace: reaction
xref: KEGG:R05218 "KEGG reaction"
xref: METACYC:R343-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24303 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01847 {cardinality="1"} ! FMNH(2)
relationship: has_input_compound UPa:UPC01847 ! FMNH(2)
relationship: has_input_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide
relationship: has_input_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide
relationship: has_output_compound UPa:UPC00061 ! FMN
relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide
relationship: part_of UPa:UER00232 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7
relationship: part_of UPa:UER00232 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7

[Term]
id: UPa:UCR05219
name: S-adenosyl-L-homocysteine + acetate + precorrin-6A = H(2)O + S-adenosyl-L-methionine + precorrin-5
namespace: reaction
xref: KEGG:R05219 "KEGG reaction"
xref: METACYC:R322-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18264 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_input_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate
relationship: has_input_compound UPa:UPC00033 ! acetate
relationship: has_input_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A
relationship: has_input_compound UPa:UPC06320 ! precorrin-6A
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_output_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_output_compound UPa:UPC06416 ! precorrin-5
relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5
relationship: part_of UPa:UER00216 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10
relationship: part_of UPa:UER00216 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10

[Term]
id: UPa:UCR05220
name: ATP + cob(I)yrinic acid a,c-diamide = adenosylcob(III)yrinic acid a,c-diamide + triphosphate
namespace: reaction
xref: KEGG:R05220 "KEGG reaction"
xref: METACYC:R344-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11531 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC06505 ! cob(I)yrinic acid a,c-diamide
relationship: has_input_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate
relationship: has_output_compound UPa:UPC00536 ! triphosphate
relationship: has_output_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide
relationship: part_of UPa:UER00233 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7
relationship: part_of UPa:UER00233 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7

[Term]
id: UPa:UCR05221
name: ATP + adenosylcobinamide = ADP + adenosylcobinamide phosphate
namespace: reaction
xref: KEGG:R05221 "KEGG reaction"
xref: METACYC:COBINAMIDEKIN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15772 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide
relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate
relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate
relationship: part_of UPa:UER00953 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00953 ! None

[Term]
id: UPa:UCR05222
name: GTP + adenosylcobinamide phosphate = adenosylcobinamide-GDP + diphosphate
namespace: reaction
xref: KEGG:R05222 "KEGG reaction"
xref: METACYC:COBINPGUANYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22715 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_input_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate
relationship: has_input_compound UPa:UPC06509 ! adenosylcobinamide phosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC06510 ! adenosylcobinamide-GDP
relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP
relationship: part_of UPa:UER00237 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7
relationship: part_of UPa:UER00237 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7

[Term]
id: UPa:UCR05223
name: GMP + adenosylcobalamin = adenosylcobinamide-GDP + alpha-ribazole
namespace: reaction
xref: KEGG:R05223 "KEGG reaction"
xref: METACYC:COBALAMINSYN-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16052 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP
relationship: has_input_compound UPa:UPC00144 ! GMP
relationship: has_input_compound UPa:UPC00194 ! adenosylcobalamin
relationship: has_input_compound UPa:UPC00194 {cardinality="1"} ! adenosylcobalamin
relationship: has_output_compound UPa:UPC05775 ! alpha-ribazole
relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole
relationship: has_output_compound UPa:UPC06510 ! adenosylcobinamide-GDP
relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP
relationship: part_of UPa:UER00238 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7
relationship: part_of UPa:UER00238 {cardinality="1", direction="RL", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7

[Term]
id: UPa:UCR05224
name: 2 ATP + 2 H(2)O + 2 L-glutamine + hydrogenobyrinic acid = 2 ADP + 2 L-glutamate + hydrogenobyrinic acid a,c-diamide + 2 phosphate
namespace: reaction
xref: KEGG:R05224 "KEGG reaction"
xref: METACYC:R341-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:12547 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC06399 ! hydrogenobyrinic acid
relationship: has_input_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide
relationship: part_of UPa:UER00220 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10
relationship: part_of UPa:UER00220 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10

[Term]
id: UPa:UCR05225
name: 4 ATP + 4 H(2)O + 4 L-glutamine + adenosylcob(III)yrinic acid a,c-diamide = 4 ADP + 4 L-glutamate + adenosylcobyrinic acid a,c-diamide + 4 phosphate
namespace: reaction
xref: KEGG:R05225 "KEGG reaction"
xref: METACYC:R345-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23259 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide
relationship: has_input_compound UPa:UPC06506 ! adenosylcob(III)yrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide
relationship: part_of UPa:UER00234 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7
relationship: part_of UPa:UER00234 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7

[Term]
id: UPa:UCR05226
name: (R)-1-aminopropan-2-ol + adenosylcobyrinic acid a,c-diamide = H(2)O + adenosylcobinamide
namespace: reaction
xref: KEGG:R05226 "KEGG reaction"
xref: METACYC:R346-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23507 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03194 {cardinality="1"} ! (R)-1-aminopropan-2-ol
relationship: has_input_compound UPa:UPC03194 ! (R)-1-aminopropan-2-ol
relationship: has_input_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide
relationship: has_input_compound UPa:UPC06507 ! adenosylcobyrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC06508 ! adenosylcobinamide
relationship: has_output_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide
relationship: part_of UPa:UER00235 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7
relationship: part_of UPa:UER00235 ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7

[Term]
id: UPa:UCR05227
name: ATP + Co(2+) + H(2)O + hydrogenobyrinic acid a,c-diamide = ADP + H(+) + cob(II)yrinate a,c-diamide + phosphate
namespace: reaction
xref: KEGG:R05227 "KEGG reaction"
xref: METACYC:R342-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15344 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00175 ! Co(2+)
relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+)
relationship: has_input_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide
relationship: has_input_compound UPa:UPC06503 ! hydrogenobyrinic acid a,c-diamide
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide
relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide
relationship: part_of UPa:UER00221 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10
relationship: part_of UPa:UER00221 ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10

[Term]
id: UPa:UCR05239
name: NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol = H(+) + NADH + biphenyl-2,3-diol
namespace: reaction
xref: KEGG:R05239 "KEGG reaction"
xref: METACYC:1.3.1.56-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17036 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol
relationship: has_input_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC02526 ! biphenyl-2,3-diol
relationship: has_output_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol
relationship: part_of UPa:UER00251 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4
relationship: part_of UPa:UER00251 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4

[Term]
id: UPa:UCR05240
name: NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid = 2,3-dihydroxy-p-cumic acid + H(+) + NADH
namespace: reaction
xref: KEGG:R05240 "KEGG reaction"
xref: METACYC:RXN-665 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:23775 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid
relationship: has_input_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid
relationship: has_output_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid
relationship: part_of UPa:UER00902 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 2/7
relationship: part_of UPa:UER00902 ! acetaldehyde and pyruvate from p-cumate: step 2/7

[Term]
id: UPa:UCR05247
name: H(+) + NADH + O(2) + p-cumate = NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid
namespace: reaction
xref: KEGG:R05247 "KEGG reaction"
xref: METACYC:RXN-664 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42347 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC06578 {cardinality="1"} ! p-cumate
relationship: has_input_compound UPa:UPC06578 ! p-cumate
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC06579 ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid
relationship: has_output_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid
relationship: part_of UPa:UER00901 ! acetaldehyde and pyruvate from p-cumate: step 1/7
relationship: part_of UPa:UER00901 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 1/7

[Term]
id: UPa:UCR05248
name: 2,3-dihydroxy-p-cumic acid + O(2) = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid
namespace: reaction
xref: KEGG:R05248 "KEGG reaction"
xref: METACYC:RXN-666 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42571 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC06580 ! 2,3-dihydroxy-p-cumic acid
relationship: has_input_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid
relationship: has_output_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_output_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: part_of UPa:UER00903 ! acetaldehyde and pyruvate from p-cumate: step 3/7
relationship: part_of UPa:UER00903 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 3/7

[Term]
id: UPa:UCR05263
name: H(+) + NADH + O(2) + biphenyl = NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol
namespace: reaction
xref: KEGG:R05263 "KEGG reaction"
xref: METACYC:1.14.12.18-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18168 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC06588 ! biphenyl
relationship: has_input_compound UPa:UPC06588 {cardinality="1"} ! biphenyl
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC06589 ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol
relationship: has_output_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol
relationship: part_of UPa:UER00250 ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4
relationship: part_of UPa:UER00250 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4

[Term]
id: UPa:UCR05275
name: NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid = 4,5-dihydroxyphthalate + H(+) + NADH
namespace: reaction
xref: KEGG:R05275 "KEGG reaction"
xref: METACYC:1.3.1.64-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13840 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC04783 ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
relationship: has_input_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC03233 ! 4,5-dihydroxyphthalate
relationship: has_output_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate
relationship: part_of UPa:UER00729 ! 3,4-dihydroxybenzoate from phthalate: step 2/3
relationship: part_of UPa:UER00729 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 2/3

[Term]
id: UPa:UCR05284
name: 1,2-dichloroethane + H(2)O = 2-chloroethanol + HCl
namespace: reaction
xref: KEGG:R05284 "KEGG reaction"
xref: METACYC:DHLAXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25188 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06752 {cardinality="1"} ! 1,2-dichloroethane
relationship: has_input_compound UPa:UPC06752 ! 1,2-dichloroethane
relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl
relationship: has_output_compound UPa:UPC01327 ! HCl
relationship: has_output_compound UPa:UPC06753 ! 2-chloroethanol
relationship: has_output_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol
relationship: part_of UPa:UER00387 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 1/4
relationship: part_of UPa:UER00387 ! glycolate from 1,2-dichloroethane: step 1/4

[Term]
id: UPa:UCR05285
name: 2-chloroethanol + 2 ferricytochrome c = 2 H(+) + chloroacetaldehyde + 2 ferrocytochrome c
namespace: reaction
xref: KEGG:R05285 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00125 ! ferricytochrome c
relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c
relationship: has_input_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol
relationship: has_input_compound UPa:UPC06753 ! 2-chloroethanol
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c
relationship: has_output_compound UPa:UPC00126 ! ferrocytochrome c
relationship: has_output_compound UPa:UPC06754 ! chloroacetaldehyde
relationship: has_output_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde
relationship: part_of UPa:UER00388 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 2/4
relationship: part_of UPa:UER00388 ! glycolate from 1,2-dichloroethane: step 2/4

[Term]
id: UPa:UCR05286
name: H(2)O + NAD(+) + chloroacetaldehyde = H(+) + NADH + chloroacetic acid
namespace: reaction
xref: KEGG:R05286 "KEGG reaction"
xref: METACYC:ALDXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:30050 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde
relationship: has_input_compound UPa:UPC06754 ! chloroacetaldehyde
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC06755 ! chloroacetic acid
relationship: has_output_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid
relationship: part_of UPa:UER00389 ! glycolate from 1,2-dichloroethane: step 3/4
relationship: part_of UPa:UER00389 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 3/4

[Term]
id: UPa:UCR05287
name: H(2)O + chloroacetic acid = HCl + glycolate
namespace: reaction
xref: KEGG:R05287 "KEGG reaction"
xref: METACYC:DHLBXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25192 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC06755 ! chloroacetic acid
relationship: has_input_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid
relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate
relationship: has_output_compound UPa:UPC00160 ! glycolate
relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl
relationship: has_output_compound UPa:UPC01327 ! HCl
relationship: part_of UPa:UER00390 ! glycolate from 1,2-dichloroethane: step 4/4
relationship: part_of UPa:UER00390 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 4/4

[Term]
id: UPa:UCR05320
name: 2-oxoglutarate + O(2) + taurine = CO(2) + aminoacetaldehyde + succinate + sulfite
namespace: reaction
xref: KEGG:R05320 "KEGG reaction"
xref: METACYC:RXN0-299 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15912 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00245 ! taurine
relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: has_output_compound UPa:UPC06735 ! aminoacetaldehyde
relationship: has_output_compound UPa:UPC06735 {cardinality="1"} ! aminoacetaldehyde
relationship: part_of UPa:UER00542 {cardinality="1", direction="LR", order="1"} ! aminoacetaldehyde and sulfite from taurine: step 1/1
relationship: part_of UPa:UER00542 ! aminoacetaldehyde and sulfite from taurine: step 1/1

[Term]
id: UPa:UCR05332
name: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
namespace: reaction
xref: KEGG:R05332 "KEGG reaction"
xref: METACYC:2.3.1.157-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13728 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC06156 ! alpha-D-glucosamine 1-phosphate
relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate
relationship: has_output_compound UPa:UPC04501 ! N-acetyl-alpha-D-glucosamine 1-phosphate
relationship: part_of UPa:UER00532 ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2
relationship: part_of UPa:UER00532 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2

[Term]
id: UPa:UCR05338
name: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate
namespace: reaction
xref: KEGG:R05338 "KEGG reaction"
xref: METACYC:R10-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25204 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00067 ! formaldehyde
relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate
relationship: has_output_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate
relationship: part_of UPa:UER00434 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2
relationship: part_of UPa:UER00434 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2

[Term]
id: UPa:UCR05339
name: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate
namespace: reaction
xref: KEGG:R05339 "KEGG reaction"
xref: METACYC:R12-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25903 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate
relationship: has_input_compound UPa:UPC06019 ! D-arabino-3-hexulose 6-phosphate
relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: part_of UPa:UER00435 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2
relationship: part_of UPa:UER00435 ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2

[Term]
id: UPa:UCR05357
name: H(2)O + amidinoproclavaminic acid = proclavaminic acid + urea
namespace: reaction
xref: KEGG:R05357 "KEGG reaction"
xref: METACYC:3.5.3.22-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17004 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid
relationship: has_input_compound UPa:UPC06657 ! amidinoproclavaminic acid
relationship: has_output_compound UPa:UPC00086 ! urea
relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea
relationship: has_output_compound UPa:UPC06658 ! proclavaminic acid
relationship: has_output_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid
relationship: part_of UPa:UER00245 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8
relationship: part_of UPa:UER00245 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8

[Term]
id: UPa:UCR05360
name: 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + salicylate
namespace: reaction
xref: KEGG:R05360 "KEGG reaction"
xref: METACYC:R608-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42471 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_input_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC00805 ! salicylate
relationship: has_output_compound UPa:UPC00805 {cardinality="1"} ! salicylate
relationship: part_of UPa:UER00778 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3
relationship: part_of UPa:UER00778 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3

[Term]
id: UPa:UCR05361
name: 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxymuconate + catechol
namespace: reaction
xref: KEGG:R05361 "KEGG reaction"
xref: RHEA:42483 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_input_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_output_compound UPa:UPC00090 ! catechol
relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol
relationship: has_output_compound UPa:UPC02501 {cardinality="1"} ! 2-hydroxymuconate
relationship: has_output_compound UPa:UPC02501 ! 2-hydroxymuconate
relationship: part_of UPa:UER00781 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3
relationship: part_of UPa:UER00781 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3

[Term]
id: UPa:UCR05364
name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + 2-methylpropanoate
namespace: reaction
xref: KEGG:R05364 "KEGG reaction"
xref: METACYC:RXN-668 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:42579 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_input_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC00596 ! 2-hydroxy-2,4-pentadienoate
relationship: has_output_compound UPa:UPC02632 ! 2-methylpropanoate
relationship: has_output_compound UPa:UPC02632 {cardinality="1"} ! 2-methylpropanoate
relationship: part_of UPa:UER00905 ! acetaldehyde and pyruvate from p-cumate: step 5/7
relationship: part_of UPa:UER00905 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 5/7

[Term]
id: UPa:UCR05377
name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid = 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + CO(2)
namespace: reaction
xref: KEGG:R05377 "KEGG reaction"
xref: METACYC:RXN-667 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:42575 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_input_compound UPa:UPC06581 ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: has_output_compound UPa:UPC06582 ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid
relationship: part_of UPa:UER00904 ! acetaldehyde and pyruvate from p-cumate: step 4/7
relationship: part_of UPa:UER00904 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 4/7

[Term]
id: UPa:UCR05378
name: 6-phospho-5-dehydro-2-deoxy-D-gluconic acid = 3-oxopropanoate + glycerone phosphate
namespace: reaction
xref: KEGG:R05378 "KEGG reaction"
xref: METACYC:4.1.2.29-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13180 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid
relationship: has_input_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid
relationship: has_output_compound UPa:UPC00111 ! glycerone phosphate
relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate
relationship: has_output_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate
relationship: has_output_compound UPa:UPC00222 ! 3-oxopropanoate
relationship: part_of UPa:UER00147 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 6/7
relationship: part_of UPa:UER00147 ! acetyl-CoA from myo-inositol: step 6/7

[Term]
id: UPa:UCR05411
name: O(2) + biphenyl-2,2',3-triol = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid
namespace: reaction
xref: KEGG:R05411 "KEGG reaction"
xref: METACYC:R607-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42467 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol
relationship: has_input_compound UPa:UPC03569 ! biphenyl-2,2',3-triol
relationship: has_output_compound UPa:UPC07731 ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_output_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: part_of UPa:UER00777 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3
relationship: part_of UPa:UER00777 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3

[Term]
id: UPa:UCR05413
name: 2,2',3-trihydroxy-diphenyl ether + O(2) = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid
namespace: reaction
xref: KEGG:R05413 "KEGG reaction"
xref: METACYC:R604-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42479 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether
relationship: has_input_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether
relationship: has_output_compound UPa:UPC07734 ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: has_output_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid
relationship: part_of UPa:UER00780 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3
relationship: part_of UPa:UER00780 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3

[Term]
id: UPa:UCR05434
name: H(+) + NADH + O(2) + dibenzofuran = NAD(+) + biphenyl-2,2',3-triol
namespace: reaction
xref: KEGG:R05434 "KEGG reaction"
xref: METACYC:R606-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42463 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC07729 {cardinality="1"} ! dibenzofuran
relationship: has_input_compound UPa:UPC07729 ! dibenzofuran
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol
relationship: has_output_compound UPa:UPC03569 ! biphenyl-2,2',3-triol
relationship: part_of UPa:UER00776 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3
relationship: part_of UPa:UER00776 ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3

[Term]
id: UPa:UCR05439
name: H(+) + NADH + O(2) + dibenzo-p-dioxin = 2,2',3-trihydroxy-diphenyl ether + NAD(+)
namespace: reaction
xref: KEGG:R05439 "KEGG reaction"
xref: RHEA:42475 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC07732 ! dibenzo-p-dioxin
relationship: has_input_compound UPa:UPC07732 {cardinality="1"} ! dibenzo-p-dioxin
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC07733 ! 2,2',3-trihydroxy-diphenyl ether
relationship: has_output_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether
relationship: part_of UPa:UER00779 ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3
relationship: part_of UPa:UER00779 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3

[Term]
id: UPa:UCR05465
name: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + phosphate
namespace: reaction
xref: KEGG:R05465 "KEGG reaction"
xref: METACYC:2.5.1.66-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10559 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00062 ! L-arginine
relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine
relationship: has_output_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine
relationship: part_of UPa:UER00242 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8
relationship: part_of UPa:UER00242 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8

[Term]
id: UPa:UCR05466
name: 2-oxoglutarate + O(2) + deoxyamidinoproclavaminic acid = CO(2) + amidinoproclavaminic acid + succinate
namespace: reaction
xref: KEGG:R05466 "KEGG reaction"
xref: METACYC:1.14.11.21-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20024 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid
relationship: has_input_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid
relationship: has_output_compound UPa:UPC06657 ! amidinoproclavaminic acid
relationship: part_of UPa:UER00244 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8
relationship: part_of UPa:UER00244 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8

[Term]
id: UPa:UCR05467
name: ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminic acid + diphosphate
namespace: reaction
xref: KEGG:R05467 "KEGG reaction"
xref: METACYC:6.3.3.4-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23623 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine
relationship: has_input_compound UPa:UPC06655 ! N(2)-(2-carboxyethyl)-L-arginine
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP
relationship: has_output_compound UPa:UPC00020 ! AMP
relationship: has_output_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid
relationship: has_output_compound UPa:UPC06656 ! deoxyamidinoproclavaminic acid
relationship: part_of UPa:UER00243 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8
relationship: part_of UPa:UER00243 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8

[Term]
id: UPa:UCR05468
name: 2-oxoglutarate + O(2) + proclavaminic acid = CO(2) + H(2)O + dihydroclavaminic acid + succinate
namespace: reaction
xref: KEGG:R05468 "KEGG reaction"
xref: METACYC:RXN-6266 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12776 "Rhea reaction"
xref: RHEA:19788 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid
relationship: has_input_compound UPa:UPC06658 ! proclavaminic acid
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid
relationship: has_output_compound UPa:UPC06659 ! dihydroclavaminic acid
relationship: part_of UPa:UER00246 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8
relationship: part_of UPa:UER00246 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8

[Term]
id: UPa:UCR05469
name: 2-oxoglutarate + O(2) + dihydroclavaminic acid = CO(2) + H(2)O + clavaminate + succinate
namespace: reaction
xref: KEGG:R05469 "KEGG reaction"
xref: METACYC:RXN-6267 "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid
relationship: has_input_compound UPa:UPC06659 ! dihydroclavaminic acid
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC06660 ! clavaminate
relationship: has_output_compound UPa:UPC06660 {cardinality="1"} ! clavaminate
relationship: part_of UPa:UER00247 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8
relationship: part_of UPa:UER00247 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8

[Term]
id: UPa:UCR05470
name: clavaminate = clavulanate-9-aldehyde
namespace: reaction
xref: KEGG:R05470 "KEGG reaction"
xref: METACYC:RXN-8892 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42431 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06660 ! clavaminate
relationship: has_input_compound UPa:UPC06660 {cardinality="1"} ! clavaminate
relationship: has_output_compound UPa:UPC06661 ! clavulanate-9-aldehyde
relationship: has_output_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde
relationship: part_of UPa:UER00248 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8
relationship: part_of UPa:UER00248 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8

[Term]
id: UPa:UCR05471
name: H(+) + NADPH + clavulanate-9-aldehyde = NADP(+) + clavulanate
namespace: reaction
xref: KEGG:R05471 "KEGG reaction"
xref: METACYC:RXN-8893 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:42071 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde
relationship: has_input_compound UPa:UPC06661 ! clavulanate-9-aldehyde
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC06662 ! clavulanate
relationship: has_output_compound UPa:UPC06662 {cardinality="1"} ! clavulanate
relationship: part_of UPa:UER00249 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8
relationship: part_of UPa:UER00249 ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8

[Term]
id: UPa:UCR05552
name: NH(3) + chorismate = 4-amino-4-deoxychorismate + H(2)O
namespace: reaction
xref: KEGG:R05552 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00014 ! NH(3)
relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_input_compound UPa:UPC00251 ! chorismate
relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate
relationship: has_output_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate
relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 1/2
relationship: part_of UPa:UER00149 ! 4-aminobenzoate from chorismate: step 1/2

[Term]
id: UPa:UCR05553
name: 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
namespace: reaction
xref: KEGG:R05553 "KEGG reaction"
xref: METACYC:ADCLY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16204 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC11355 ! 4-amino-4-deoxychorismate
relationship: has_input_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00568 ! 4-aminobenzoate
relationship: has_output_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate
relationship: part_of UPa:UER00150 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 2/2
relationship: part_of UPa:UER00150 ! 4-aminobenzoate from chorismate: step 2/2

[Term]
id: UPa:UCR05554
name: 2-ureidoglycine + H(2)O = (S)-ureidoglycolate + NH(3)
namespace: reaction
xref: KEGG:R05554 "KEGG reaction"
xref: METACYC:URUR-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25244 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC02091 ! 2-ureidoglycine
relationship: has_input_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate
relationship: has_output_compound UPa:UPC00603 ! (S)-ureidoglycolate
relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="2"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1
relationship: part_of UPa:UER00655 ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1

[Term]
id: UPa:UCR05558
name: H(2)O + atrazine = HCl + hydroxyatrazine
namespace: reaction
xref: KEGG:R05558 "KEGG reaction"
xref: METACYC:3.8.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:11315 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06551 ! atrazine
relationship: has_input_compound UPa:UPC06551 {cardinality="1"} ! atrazine
relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl
relationship: has_output_compound UPa:UPC01327 ! HCl
relationship: has_output_compound UPa:UPC06552 ! hydroxyatrazine
relationship: has_output_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine
relationship: part_of UPa:UER00499 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 1/3
relationship: part_of UPa:UER00499 ! cyanurate from atrazine: step 1/3

[Term]
id: UPa:UCR05559
name: H(2)O + hydroxyatrazine = N-isopropylammelide + ethylamine
namespace: reaction
xref: KEGG:R05559 "KEGG reaction"
xref: METACYC:R122-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23095 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06552 ! hydroxyatrazine
relationship: has_input_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine
relationship: has_output_compound UPa:UPC00797 ! ethylamine
relationship: has_output_compound UPa:UPC00797 {cardinality="1"} ! ethylamine
relationship: has_output_compound UPa:UPC06553 ! N-isopropylammelide
relationship: has_output_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide
relationship: part_of UPa:UER00500 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 2/3
relationship: part_of UPa:UER00500 ! cyanurate from atrazine: step 2/3

[Term]
id: UPa:UCR05560
name: H(2)O + N-isopropylammelide = cyanurate + isopropylamine
namespace: reaction
xref: KEGG:R05560 "KEGG reaction"
xref: METACYC:R123-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23611 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC06553 ! N-isopropylammelide
relationship: has_input_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide
relationship: has_output_compound UPa:UPC06554 ! cyanurate
relationship: has_output_compound UPa:UPC06554 {cardinality="1"} ! cyanurate
relationship: has_output_compound UPa:UPC06748 ! isopropylamine
relationship: has_output_compound UPa:UPC06748 {cardinality="1"} ! isopropylamine
relationship: part_of UPa:UER00501 ! cyanurate from atrazine: step 3/3
relationship: part_of UPa:UER00501 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 3/3

[Term]
id: UPa:UCR05605
name: 2-dehydro-3-deoxy-6-phospho-D-gluconic acid = D-glyceraldehyde 3-phosphate + pyruvate
namespace: reaction
xref: KEGG:R05605 "KEGG reaction"
xref: METACYC:KDPGALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17092 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04442 ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid
relationship: has_input_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid
relationship: has_output_compound UPa:UPC00022 ! pyruvate
relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_output_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: part_of UPa:UER00829 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2
relationship: part_of UPa:UER00829 ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2

[Term]
id: UPa:UCR05608
name: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O
namespace: reaction
xref: KEGG:R05608 "KEGG reaction"
xref: METACYC:GALACTARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16008 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00879 ! galactarate
relationship: has_input_compound UPa:UPC00879 {cardinality="1"} ! galactarate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate
relationship: has_output_compound UPa:UPC00679 ! 5-dehydro-4-deoxy-D-glucarate
relationship: part_of UPa:UER00629 ! D-glycerate from galactarate: step 1/3
relationship: part_of UPa:UER00629 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 1/3

[Term]
id: UPa:UCR05621
name: H(+) + NADH + O(2) + benzoate = (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+)
namespace: reaction
xref: KEGG:R05621 "KEGG reaction"
xref: METACYC:BENZOATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12636 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate
relationship: has_input_compound UPa:UPC00180 ! benzoate
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid
relationship: has_output_compound UPa:UPC06321 ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid
relationship: part_of UPa:UER00254 ! catechol from benzoate: step 1/2
relationship: part_of UPa:UER00254 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 1/2

[Term]
id: UPa:UCR05633
name: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate
namespace: reaction
xref: KEGG:R05633 "KEGG reaction"
xref: METACYC:2.7.7.60-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13432 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00063 ! CTP
relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP
relationship: has_input_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate
relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol
relationship: has_output_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol
relationship: part_of UPa:UER00093 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6
relationship: part_of UPa:UER00093 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6

[Term]
id: UPa:UCR05634
name: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP
namespace: reaction
xref: KEGG:R05634 "KEGG reaction"
xref: METACYC:2.7.1.148-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18440 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC11435 ! 4-CDP-2-C-methyl-D-erythritol
relationship: has_input_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate
relationship: has_output_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate
relationship: part_of UPa:UER00094 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6
relationship: part_of UPa:UER00094 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6

[Term]
id: UPa:UCR05636
name: D-glyceraldehyde 3-phosphate + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)
namespace: reaction
xref: KEGG:R05636 "KEGG reaction"
xref: METACYC:DXS-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:12608 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate
relationship: has_input_compound UPa:UPC00118 ! D-glyceraldehyde 3-phosphate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate
relationship: part_of UPa:UER00091 {cardinality="1", direction="LR", order="1"} ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1
relationship: part_of UPa:UER00091 ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1

[Term]
id: UPa:UCR05637
name: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
namespace: reaction
xref: KEGG:R05637 "KEGG reaction"
xref: METACYC:RXN0-302 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23867 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate
relationship: has_input_compound UPa:UPC11436 ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC11453 ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate
relationship: has_output_compound UPa:UPC11453 {cardinality="1"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate
relationship: part_of UPa:UER00095 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6
relationship: part_of UPa:UER00095 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6

[Term]
id: UPa:UCR05639
name: 14-demethyllanosterol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH
namespace: reaction
xref: KEGG:R05639 "KEGG reaction"
xref: METACYC:RXN66-306 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18564 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC05108 {cardinality="1"} ! 14-demethyllanosterol
relationship: has_input_compound UPa:UPC05108 ! 14-demethyllanosterol
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
relationship: part_of UPa:UER00755 {cardinality="1", direction="RL", order="1"} ! zymosterol from lanosterol: step 2/6
relationship: part_of UPa:UER00755 ! zymosterol from lanosterol: step 2/6

[Term]
id: UPa:UCR05640
name: 3 H(+) + 3 NADPH + 3 O(2) + lanosterol = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 4 H(2)O + 3 NADP(+) + formate
namespace: reaction
xref: KEGG:R05640 "KEGG reaction"
xref: METACYC:RXN3O-130 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25289 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC01724 {cardinality="1"} ! lanosterol
relationship: has_input_compound UPa:UPC01724 ! lanosterol
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC11455 ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
relationship: part_of UPa:UER00754 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 1/6
relationship: part_of UPa:UER00754 ! zymosterol from lanosterol: step 1/6

[Term]
id: UPa:UCR05641
name: NADP(+) + ergosterol = H(+) + NADPH + ergosta-5,7,22,24(28)-tetraen-3beta-ol
namespace: reaction
xref: KEGG:R05641 "KEGG reaction"
xref: METACYC:1.3.1.71-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18504 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC01694 {cardinality="1"} ! ergosterol
relationship: has_input_compound UPa:UPC01694 ! ergosterol
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC05440 ! ergosta-5,7,22,24(28)-tetraen-3beta-ol
relationship: has_output_compound UPa:UPC05440 {cardinality="1"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol
relationship: part_of UPa:UER00764 ! ergosterol from zymosterol: step 5/5
relationship: part_of UPa:UER00764 {cardinality="1", direction="RL", order="1"} ! ergosterol from zymosterol: step 5/5

[Term]
id: UPa:UCR05644
name: ATP + D-glycero-beta-D-manno-heptose 1-phosphate = ADP-D-glycero-beta-D-manno-heptose + diphosphate
namespace: reaction
xref: KEGG:R05644 "KEGG reaction"
xref: METACYC:RXN0-4342 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:27468 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate
relationship: has_input_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose
relationship: has_output_compound UPa:UPC06397 ! ADP-D-glycero-beta-D-manno-heptose
relationship: part_of UPa:UER00439 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4
relationship: part_of UPa:UER00439 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4

[Term]
id: UPa:UCR05646
name: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-diphosphate
namespace: reaction
xref: KEGG:R05646 "KEGG reaction"
xref: RHEA:27476 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC07836 ! D-glycero-beta-D-manno-heptose 7-phosphate
relationship: has_input_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate
relationship: has_output_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate
relationship: part_of UPa:UER00437 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4
relationship: part_of UPa:UER00437 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4

[Term]
id: UPa:UCR05647
name: D-glycero-beta-D-manno-heptose 1,7-diphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
namespace: reaction
xref: KEGG:R05647 "KEGG reaction"
xref: METACYC:RXN0-4361 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28521 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate
relationship: has_input_compound UPa:UPC11472 ! D-glycero-beta-D-manno-heptose 1,7-diphosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC07838 ! D-glycero-beta-D-manno-heptose 1-phosphate
relationship: has_output_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate
relationship: part_of UPa:UER00438 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4
relationship: part_of UPa:UER00438 ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4

[Term]
id: UPa:UCR05651
name: phosphate + sulfoacetaldehyde = acetyl phosphate + sulfite
namespace: reaction
xref: KEGG:R05651 "KEGG reaction"
xref: METACYC:RXN-2364 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24207 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_input_compound UPa:UPC00009 ! phosphate
relationship: has_input_compound UPa:UPC00593 ! sulfoacetaldehyde
relationship: has_input_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_output_compound UPa:UPC00227 ! acetyl phosphate
relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate
relationship: part_of UPa:UER00544 ! acetyl phosphate and sulfite from taurine: step 2/2
relationship: part_of UPa:UER00544 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 2/2

[Term]
id: UPa:UCR05652
name: pyruvate + taurine = L-alanine + sulfoacetaldehyde
namespace: reaction
xref: KEGG:R05652 "KEGG reaction"
xref: METACYC:TAURINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:10423 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine
relationship: has_input_compound UPa:UPC00245 ! taurine
relationship: has_output_compound UPa:UPC00041 ! L-alanine
relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine
relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde
relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde
relationship: part_of UPa:UER00543 ! acetyl phosphate and sulfite from taurine: step 1/2
relationship: part_of UPa:UER00543 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 1/2

[Term]
id: UPa:UCR05661
name: 2-deoxy-5-keto-D-gluconic acid + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconic acid + ADP
namespace: reaction
xref: KEGG:R05661 "KEGG reaction"
xref: METACYC:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13500 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC06892 {cardinality="1"} ! 2-deoxy-5-keto-D-gluconic acid
relationship: has_input_compound UPa:UPC06892 ! 2-deoxy-5-keto-D-gluconic acid
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC06893 ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid
relationship: has_output_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid
relationship: part_of UPa:UER00146 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 5/7
relationship: part_of UPa:UER00146 ! acetyl-CoA from myo-inositol: step 5/7

[Term]
id: UPa:UCR05681
name: 4-(phosphonooxy)-L-threonine + NAD(+) = 2-amino-3-oxo-4-phosphonooxybutyrate + H(+) + NADH
namespace: reaction
xref: KEGG:R05681 "KEGG reaction"
xref: METACYC:1.1.1.262-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14456 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine
relationship: has_input_compound UPa:UPC06055 ! 4-(phosphonooxy)-L-threonine
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate
relationship: has_output_compound UPa:UPC07335 ! 2-amino-3-oxo-4-phosphonooxybutyrate
relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5
relationship: part_of UPa:UER00312 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5

[Term]
id: UPa:UCR05688
name: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
namespace: reaction
xref: KEGG:R05688 "KEGG reaction"
xref: METACYC:DXPREDISOM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:13720 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC11434 ! 2-C-methyl-D-erythritol 4-phosphate
relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate
relationship: part_of UPa:UER00092 {cardinality="1", direction="RL", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6
relationship: part_of UPa:UER00092 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6

[Term]
id: UPa:UCR05692
name: GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + H(+) + NADPH
namespace: reaction
xref: KEGG:R05692 "KEGG reaction"
xref: METACYC:1.1.1.271-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18888 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00325 ! GDP-L-fucose
relationship: has_input_compound UPa:UPC00325 {cardinality="1"} ! GDP-L-fucose
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01222 ! GDP-4-dehydro-6-deoxy-D-mannose
relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose
relationship: part_of UPa:UER00191 ! GDP-L-fucose from GDP-alpha-D-mannose: step 2/2
relationship: part_of UPa:UER00191 {cardinality="1", direction="RL", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 2/2

[Term]
id: UPa:UCR05728
name: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R05728 "KEGG reaction"
xref: METACYC:1.14.13.68-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18404 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC04353 {cardinality="1"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime
relationship: has_input_compound UPa:UPC04353 ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC03742 ! (S)-4-hydroxymandelonitrile
relationship: has_output_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile
relationship: part_of UPa:UER00745 ! dhurrin from L-tyrosine: step 2/3
relationship: part_of UPa:UER00745 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 2/3

[Term]
id: UPa:UCR05732
name: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R05732 "KEGG reaction"
xref: METACYC:1.14.13.71-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16652 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC05176 ! (S)-N-methylcoclaurine
relationship: has_input_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine
relationship: has_output_compound UPa:UPC05202 ! (S)-3'-hydroxy-N-methylcoclaurine
relationship: part_of UPa:UER00443 ! (S)-reticuline from (S)-norcoclaurine: step 3/4
relationship: part_of UPa:UER00443 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 3/4

[Term]
id: UPa:UCR05765
name: geranyl diphosphate = (-)-alpha-pinene + diphosphate
namespace: reaction
xref: KEGG:R05765 "KEGG reaction"
xref: METACYC:RXN-5106 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25491 "Rhea reaction"
xref: RHEA:25665 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC06308 {cardinality="1"} ! (-)-alpha-pinene
relationship: has_output_compound UPa:UPC06308 ! (-)-alpha-pinene
relationship: part_of UPa:UER00927 {cardinality="1", direction="LR", order="1"} ! (-)-alpha-pinene from geranyl diphosphate: step 1/1
relationship: part_of UPa:UER00927 ! (-)-alpha-pinene from geranyl diphosphate: step 1/1

[Term]
id: UPa:UCR05766
name: geranyl diphosphate = (-)-beta-pinene + diphosphate
namespace: reaction
xref: KEGG:R05766 "KEGG reaction"
xref: METACYC:RXN-5107 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25499 "Rhea reaction"
xref: RHEA:25669 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC06307 {cardinality="1"} ! (-)-beta-pinene
relationship: has_output_compound UPa:UPC06307 ! (-)-beta-pinene
relationship: part_of UPa:UER00928 {cardinality="1", direction="LR", order="1"} ! (-)-beta-pinene from geranyl diphosphate: step 1/1
relationship: part_of UPa:UER00928 ! (-)-beta-pinene from geranyl diphosphate: step 1/1

[Term]
id: UPa:UCR05768
name: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + GDP
namespace: reaction
xref: KEGG:R05768 "KEGG reaction"
xref: METACYC:2.4.1.217-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13540 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose
relationship: has_input_compound UPa:UPC00096 ! GDP-alpha-D-mannose
relationship: has_input_compound UPa:UPC00197 ! 3-phospho-D-glycerate
relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate
relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP
relationship: has_output_compound UPa:UPC00035 ! GDP
relationship: has_output_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid
relationship: has_output_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid
relationship: part_of UPa:UER00192 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2
relationship: part_of UPa:UER00192 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2

[Term]
id: UPa:UCR05774
name: 3-sulfopyruvate = CO(2) + sulfoacetaldehyde
namespace: reaction
xref: KEGG:R05774 "KEGG reaction"
xref: METACYC:R231-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20951 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate
relationship: has_input_compound UPa:UPC05528 ! 3-sulfopyruvate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde
relationship: has_output_compound UPa:UPC00593 ! sulfoacetaldehyde
relationship: part_of UPa:UER00472 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4
relationship: part_of UPa:UER00472 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4

[Term]
id: UPa:UCR05784
name: (4R)-limonene 1,2-epoxide + H(2)O = (1S,2S,4R)-limonene-1,2-diol
namespace: reaction
xref: KEGG:R05784 "KEGG reaction"
xref: METACYC:RXN-9412 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10703 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide
relationship: has_input_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide
relationship: has_output_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol
relationship: has_output_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol
relationship: part_of UPa:UER00865 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3
relationship: part_of UPa:UER00865 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3

[Term]
id: UPa:UCR05789
name: (2R)-O-phospho-3-sulfolactic acid + H(2)O = (R)-3-sulfolactate + phosphate
namespace: reaction
xref: KEGG:R05789 "KEGG reaction"
xref: METACYC:R229-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23419 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid
relationship: has_input_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC11537 ! (R)-3-sulfolactate
relationship: has_output_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate
relationship: part_of UPa:UER00470 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4
relationship: part_of UPa:UER00470 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4

[Term]
id: UPa:UCR05790
name: 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate
namespace: reaction
xref: KEGG:R05790 "KEGG reaction"
xref: METACYC:3.1.3.70-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19312 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid
relationship: has_input_compound UPa:UPC11516 ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC11544 ! 2-(alpha-D-mannosyl)-D-glycerate
relationship: has_output_compound UPa:UPC11544 {cardinality="1"} ! 2-(alpha-D-mannosyl)-D-glycerate
relationship: part_of UPa:UER00193 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2
relationship: part_of UPa:UER00193 ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2

[Term]
id: UPa:UCR05794
name: CDP-diacylglycerol + choline = CMP + phosphatidylcholine
namespace: reaction
xref: KEGG:R05794 "KEGG reaction"
xref: METACYC:2.7.8.24-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:14600 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00114 ! choline
relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_input_compound UPa:UPC00269 ! CDP-diacylglycerol
relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol
relationship: has_output_compound UPa:UPC00055 ! CMP
relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP
relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine
relationship: has_output_compound UPa:UPC00157 ! phosphatidylcholine
relationship: part_of UPa:UER00940 ! phosphatidylcholine from choline: step 1/1
relationship: part_of UPa:UER00940 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from choline: step 1/1

[Term]
id: UPa:UCR05807
name: Co(2+) + sirohydrochlorin = 2 H(+) + cobalt-precorrin-2
namespace: reaction
xref: KEGG:R05807 "KEGG reaction"
xref: METACYC:4.99.1.3-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15896 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00175 ! Co(2+)
relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+)
relationship: has_input_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin
relationship: has_input_compound UPa:UPC05778 ! sirohydrochlorin
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC11538 ! cobalt-precorrin-2
relationship: has_output_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2
relationship: part_of UPa:UER00223 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10
relationship: part_of UPa:UER00223 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10

[Term]
id: UPa:UCR05808
name: S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-factor III
namespace: reaction
xref: KEGG:R05808 "KEGG reaction"
xref: METACYC:2.1.1.151-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18000 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC11538 ! cobalt-precorrin-2
relationship: has_input_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC17401 ! cobalt-factor III
relationship: has_output_compound UPa:UPC17401 {cardinality="1"} ! cobalt-factor III
relationship: part_of UPa:UER00224 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10
relationship: part_of UPa:UER00224 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10

[Term]
id: UPa:UCR05809
name: S-adenosyl-L-methionine + cobalt-precorrin 3 = S-adenosyl-L-homocysteine + cobalt-precorrin 4
namespace: reaction
xref: KEGG:R05809 "KEGG reaction"
xref: METACYC:RXN-8761 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26276 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC11539 ! cobalt-precorrin 3
relationship: has_input_compound UPa:UPC11539 {cardinality="1"} ! cobalt-precorrin 3
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC11540 ! cobalt-precorrin 4
relationship: has_output_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4
relationship: part_of UPa:UER00225 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10
relationship: part_of UPa:UER00225 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10

[Term]
id: UPa:UCR05810
name: S-adenosyl-L-methionine + cobalt-precorrin 4 = S-adenosyl-L-homocysteine + cobalt-precorrin 5A
namespace: reaction
xref: KEGG:R05810 "KEGG reaction"
xref: METACYC:RXN-8762 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26280 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4
relationship: has_input_compound UPa:UPC11540 ! cobalt-precorrin 4
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC16242 {cardinality="1"} ! cobalt-precorrin 5A
relationship: has_output_compound UPa:UPC16242 ! cobalt-precorrin 5A
relationship: part_of UPa:UER00226 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10
relationship: part_of UPa:UER00226 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10

[Term]
id: UPa:UCR05812
name: H(+) + NADH + cobalt-precorrin-6A = NAD(+) + cobalt-precorrin-6B
namespace: reaction
xref: KEGG:R05812 "KEGG reaction"
xref: METACYC:RXN-8765 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15628 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC11542 {cardinality="1"} ! cobalt-precorrin-6A
relationship: has_input_compound UPa:UPC11542 ! cobalt-precorrin-6A
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B
relationship: has_output_compound UPa:UPC11543 ! cobalt-precorrin-6B
relationship: part_of UPa:UER00228 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10
relationship: part_of UPa:UER00228 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10

[Term]
id: UPa:UCR05813
name: 2 S-adenosyl-L-methionine + cobalt-precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + cobalt-precorrin 8
namespace: reaction
xref: KEGG:R05813 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B
relationship: has_input_compound UPa:UPC11543 ! cobalt-precorrin-6B
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8
relationship: has_output_compound UPa:UPC11545 ! cobalt-precorrin 8
relationship: part_of UPa:UER00229 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10
relationship: part_of UPa:UER00229 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10

[Term]
id: UPa:UCR05814
name: cobalt-precorrin 8 = cob(III)yrinic acid
namespace: reaction
xref: KEGG:R05814 "KEGG reaction"
xref: METACYC:RXN-8768 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16212 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8
relationship: has_input_compound UPa:UPC11545 ! cobalt-precorrin 8
relationship: has_output_compound UPa:UPC05773 ! cob(III)yrinic acid
relationship: has_output_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid
relationship: part_of UPa:UER00230 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10
relationship: part_of UPa:UER00230 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10

[Term]
id: UPa:UCR05815
name: 2 ATP + 2 H(2)O + 2 L-glutamine + cob(III)yrinic acid = 2 ADP + 2 L-glutamate + cob(II)yrinate a,c-diamide + 2 phosphate
namespace: reaction
xref: KEGG:R05815 "KEGG reaction"
xref: METACYC:RXN-8769 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26292 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00064 ! L-glutamine
relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine
relationship: has_input_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid
relationship: has_input_compound UPa:UPC05773 ! cob(III)yrinic acid
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC06504 ! cob(II)yrinate a,c-diamide
relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide
relationship: part_of UPa:UER00231 ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10
relationship: part_of UPa:UER00231 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10

[Term]
id: UPa:UCR05820
name: D-sorbitol + protein N(pi)-phospho-L-histidine = D-sorbitol 6-phosphate + protein-L-histidine
namespace: reaction
xref: KEGG:R05820 "KEGG reaction"
xref: RHEA:42487 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol
relationship: has_input_compound UPa:UPC00794 ! D-sorbitol
relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine
relationship: has_input_compound UPa:UPC04261 ! protein N(pi)-phospho-L-histidine
relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine
relationship: has_output_compound UPa:UPC00615 ! protein-L-histidine
relationship: has_output_compound UPa:UPC01096 ! D-sorbitol 6-phosphate
relationship: has_output_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate
relationship: part_of UPa:UER00782 ! D-sorbitol 6-phosphate from D-sorbitol: step 1/1
relationship: part_of UPa:UER00782 {cardinality="1", direction="LR", order="1"} ! D-sorbitol 6-phosphate from D-sorbitol: step 1/1

[Term]
id: UPa:UCR05838
name: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + phosphate + pyridoxine 5'-phosphate
namespace: reaction
xref: KEGG:R05838 "KEGG reaction"
xref: METACYC:PDXJ-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15268 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate
relationship: has_input_compound UPa:UPC11437 ! 1-deoxy-D-xylulose 5-phosphate
relationship: has_input_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate
relationship: has_input_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00627 ! pyridoxine 5'-phosphate
relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate
relationship: part_of UPa:UER00313 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5
relationship: part_of UPa:UER00313 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5

[Term]
id: UPa:UCR05850
name: L-ribulose 5-phosphate = D-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R05850 "KEGG reaction"
xref: METACYC:RIBULPEPIM-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22371 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC01101 ! L-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 ! D-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate
relationship: part_of UPa:UER00380 ! D-xylulose 5-phosphate from L-ascorbate: step 4/4
relationship: part_of UPa:UER00380 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 4/4
relationship: part_of UPa:UER00567 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3
relationship: part_of UPa:UER00567 ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3

[Term]
id: UPa:UCR05855
name: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R05855 "KEGG reaction"
xref: METACYC:1.14.13.73-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14136 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC09244 ! tabersonine
relationship: has_input_compound UPa:UPC09244 {cardinality="1"} ! tabersonine
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC11643 ! 16-hydroxytabersonine
relationship: has_output_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine
relationship: part_of UPa:UER00521 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 1/6
relationship: part_of UPa:UER00521 ! vindoline from tabersonine: step 1/6

[Term]
id: UPa:UCR05856
name: 16-methoxytabersonine + H(2)O = 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
namespace: reaction
xref: KEGG:R05856 "KEGG reaction"
xref: METACYC:RXN-8200 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:42375 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC11675 ! 16-methoxytabersonine
relationship: has_input_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine
relationship: has_output_compound UPa:UPC04578 ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
relationship: has_output_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
relationship: part_of UPa:UER00523 ! vindoline from tabersonine: step 3/6
relationship: part_of UPa:UER00523 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 3/6

[Term]
id: UPa:UCR05857
name: 2-oxoglutarate + O(2) + desacetoxyvindoline = CO(2) + deacetylvindoline + succinate
namespace: reaction
xref: KEGG:R05857 "KEGG reaction"
xref: METACYC:1.14.11.20-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18976 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC02673 ! desacetoxyvindoline
relationship: has_input_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00042 ! succinate
relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate
relationship: has_output_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline
relationship: has_output_compound UPa:UPC01091 ! deacetylvindoline
relationship: part_of UPa:UER00525 ! vindoline from tabersonine: step 5/6
relationship: part_of UPa:UER00525 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 5/6

[Term]
id: UPa:UCR05884
name: (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH = H(2)O + NADP(+) + isopentenyl diphosphate
namespace: reaction
xref: KEGG:R05884 "KEGG reaction"
xref: METACYC:ISPH2-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24491 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate
relationship: has_input_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00129 ! isopentenyl diphosphate
relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate
relationship: part_of UPa:UER00097 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6
relationship: part_of UPa:UER00097 ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6

[Term]
id: UPa:UCR05885
name: 16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R05885 "KEGG reaction"
xref: METACYC:2.1.1.94-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20995 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC11643 ! 16-hydroxytabersonine
relationship: has_input_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine
relationship: has_output_compound UPa:UPC11675 ! 16-methoxytabersonine
relationship: part_of UPa:UER00522 ! vindoline from tabersonine: step 2/6
relationship: part_of UPa:UER00522 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 2/6

[Term]
id: UPa:UCR06117
name: (4S,6R)-trans-carveol + NAD(+) = (S)-carvone + H(+) + NADH
namespace: reaction
xref: KEGG:R06117 "KEGG reaction"
xref: METACYC:RXN-9397 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14828 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC11409 ! (4S,6R)-trans-carveol
relationship: has_input_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC11383 ! (S)-carvone
relationship: has_output_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone
relationship: part_of UPa:UER00868 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3
relationship: part_of UPa:UER00868 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3

[Term]
id: UPa:UCR06119
name: (4R)-limonene + H(+) + NADPH + O(2) = (4S,6R)-trans-carveol + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R06119 "KEGG reaction"
xref: METACYC:RXN-10746 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18960 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene
relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol
relationship: has_output_compound UPa:UPC11409 ! (4S,6R)-trans-carveol
relationship: part_of UPa:UER00867 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3
relationship: part_of UPa:UER00867 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3

[Term]
id: UPa:UCR06120
name: geranyl diphosphate = (4R)-limonene + diphosphate
namespace: reaction
xref: KEGG:R06120 "KEGG reaction"
xref: METACYC:4.2.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10943 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00341 ! geranyl diphosphate
relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene
relationship: has_output_compound UPa:UPC06099 ! (4R)-limonene
relationship: part_of UPa:UER00926 ! (4R)-limonene from geranyl diphosphate: step 1/1
relationship: part_of UPa:UER00926 {cardinality="1", direction="LR", order="1"} ! (4R)-limonene from geranyl diphosphate: step 1/1

[Term]
id: UPa:UCR06171
name: L-allo-threonine = acetaldehyde + glycine
namespace: reaction
xref: KEGG:R06171 "KEGG reaction"
xref: METACYC:LTAA-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:26212 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05519 ! L-allo-threonine
relationship: has_input_compound UPa:UPC05519 {cardinality="1"} ! L-allo-threonine
relationship: has_output_compound UPa:UPC00037 ! glycine
relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine
relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde
relationship: has_output_compound UPa:UPC00084 ! acetaldehyde
relationship: part_of UPa:UER00427 ! glycine from L-allo-threonine: step 1/1
relationship: part_of UPa:UER00427 {cardinality="1", direction="LR", order="1"} ! glycine from L-allo-threonine: step 1/1

[Term]
id: UPa:UCR06180
name: L-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH
namespace: reaction
xref: KEGG:R06180 "KEGG reaction"
xref: METACYC:TARTRATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15212 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00898 ! L-tartrate
relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC03459 ! 2-hydroxy-3-oxosuccinate
relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate
relationship: part_of UPa:UER00800 ! 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1
relationship: part_of UPa:UER00800 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1

[Term]
id: UPa:UCR06223
name: H(+) + NADPH + 2 farnesyl diphosphate = NADP(+) + 2 diphosphate + squalene
namespace: reaction
xref: KEGG:R06223 "KEGG reaction"
xref: RHEA:32298 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00751 {cardinality="1"} ! squalene
relationship: has_output_compound UPa:UPC00751 ! squalene
relationship: part_of UPa:UER00751 ! lanosterol from farnesyl diphosphate: step 1/3
relationship: part_of UPa:UER00751 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 1/3

[Term]
id: UPa:UCR06305
name: geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene
namespace: reaction
xref: KEGG:R06305 "KEGG reaction"
xref: METACYC:4.2.3.17-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20915 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate
relationship: has_input_compound UPa:UPC00353 ! geranylgeranyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC11894 ! taxa-4,11-diene
relationship: has_output_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene
relationship: part_of UPa:UER00806 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2
relationship: part_of UPa:UER00806 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2

[Term]
id: UPa:UCR06306
name: O(2) + reduced acceptor + taxa-4,11-diene = H(2)O + acceptor + taxa-4(20),11-dien-5alpha-ol
namespace: reaction
xref: KEGG:R06306 "KEGG reaction"
xref: METACYC:1.14.99.37-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14052 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00030 ! reduced acceptor
relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_input_compound UPa:UPC11894 ! taxa-4,11-diene
relationship: has_input_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_output_compound UPa:UPC00028 ! acceptor
relationship: has_output_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol
relationship: has_output_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol
relationship: part_of UPa:UER00807 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2
relationship: part_of UPa:UER00807 ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2

[Term]
id: UPa:UCR06307
name: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate
namespace: reaction
xref: KEGG:R06307 "KEGG reaction"
xref: METACYC:2.3.1.162-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:22031 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol
relationship: has_input_compound UPa:UPC11895 ! taxa-4(20),11-dien-5alpha-ol
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate
relationship: has_output_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate
relationship: part_of UPa:UER00808 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3
relationship: part_of UPa:UER00808 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3

[Term]
id: UPa:UCR06309
name: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R06309 "KEGG reaction"
xref: METACYC:1.14.13.76-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15244 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate
relationship: has_input_compound UPa:UPC11896 ! taxa-4(20),11-dien-5alpha-yl acetate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC11898 ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate
relationship: has_output_compound UPa:UPC11898 {cardinality="1"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate
relationship: part_of UPa:UER00809 ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3
relationship: part_of UPa:UER00809 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3

[Term]
id: UPa:UCR06310
name: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA
namespace: reaction
xref: KEGG:R06310 "KEGG reaction"
xref: METACYC:2.3.1.166-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18744 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00512 ! benzoyl-CoA
relationship: has_input_compound UPa:UPC00512 {cardinality="1"} ! benzoyl-CoA
relationship: has_input_compound UPa:UPC11899 ! 10-deacetyl-2-debenzoylbaccatin III
relationship: has_input_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC11700 ! 10-deacetylbaccatin III
relationship: has_output_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III
relationship: part_of UPa:UER00810 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2
relationship: part_of UPa:UER00810 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2

[Term]
id: UPa:UCR06311
name: 10-deacetylbaccatin III + acetyl-CoA = CoA + baccatin III
namespace: reaction
xref: KEGG:R06311 "KEGG reaction"
xref: METACYC:2.3.1.167-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20140 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III
relationship: has_input_compound UPa:UPC11700 ! 10-deacetylbaccatin III
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC11900 ! baccatin III
relationship: has_output_compound UPa:UPC11900 {cardinality="1"} ! baccatin III
relationship: part_of UPa:UER00811 ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2
relationship: part_of UPa:UER00811 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2

[Term]
id: UPa:UCR06372
name: (S)-carvone + reduced acceptor = (1R,4S)-isodihydrocarvone + acceptor
namespace: reaction
xref: KEGG:R06372 "KEGG reaction"
xref: METACYC:RXN-9419 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:32430 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00030 ! reduced acceptor
relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor
relationship: has_input_compound UPa:UPC11383 ! (S)-carvone
relationship: has_input_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone
relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor
relationship: has_output_compound UPa:UPC00028 ! acceptor
relationship: has_output_compound UPa:UPC11412 ! (1R,4S)-isodihydrocarvone
relationship: has_output_compound UPa:UPC11412 {cardinality="1"} ! (1R,4S)-isodihydrocarvone
relationship: part_of UPa:UER00869 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3
relationship: part_of UPa:UER00869 ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3

[Term]
id: UPa:UCR06398
name: (4R)-limonene + H(+) + NADH + O(2) = (4R)-limonene 1,2-epoxide + H(2)O + NAD(+)
namespace: reaction
xref: KEGG:R06398 "KEGG reaction"
xref: RHEA:26096 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene
relationship: has_input_compound UPa:UPC06099 ! (4R)-limonene
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC07271 ! (4R)-limonene 1,2-epoxide
relationship: has_output_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide
relationship: part_of UPa:UER00864 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3
relationship: part_of UPa:UER00864 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3

[Term]
id: UPa:UCR06399
name: (1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH
namespace: reaction
xref: KEGG:R06399 "KEGG reaction"
xref: METACYC:RXN-9949 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:32386 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol
relationship: has_input_compound UPa:UPC07276 ! (1S,2S,4R)-limonene-1,2-diol
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC11937 {cardinality="1"} ! (1S,4R)-1-hydroxylimonen-2-one
relationship: has_output_compound UPa:UPC11937 ! (1S,4R)-1-hydroxylimonen-2-one
relationship: part_of UPa:UER00866 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3
relationship: part_of UPa:UER00866 ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3

[Term]
id: UPa:UCR06558
name: GTP + adenosylcobinamide = GDP + adenosylcobinamide phosphate
namespace: reaction
xref: KEGG:R06558 "KEGG reaction"
xref: METACYC:RXN-14063 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:15768 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00044 ! GTP
relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP
relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide
relationship: has_input_compound UPa:UPC06508 ! adenosylcobinamide
relationship: has_output_compound UPa:UPC00035 ! GDP
relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP
relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate
relationship: has_output_compound UPa:UPC06509 ! adenosylcobinamide phosphate
relationship: part_of UPa:UER00954 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00954 ! None

[Term]
id: UPa:UCR06601
name: 5-hydroxyisouric acid + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid
namespace: reaction
xref: KEGG:R06601 "KEGG reaction"
xref: METACYC:3.5.2.17-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23739 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid
relationship: has_input_compound UPa:UPC11821 ! 5-hydroxyisouric acid
relationship: has_output_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid
relationship: has_output_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid
relationship: part_of UPa:UER00651 ! (S)-allantoin from urate: step 2/3
relationship: part_of UPa:UER00651 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 2/3

[Term]
id: UPa:UCR06604
name: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid = (S)-allantoin + CO(2)
namespace: reaction
xref: KEGG:R06604 "KEGG reaction"
xref: METACYC:RXN-6201 "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid
relationship: has_input_compound UPa:UPC12248 ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC02350 ! (S)-allantoin
relationship: has_output_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin
relationship: part_of UPa:UER00652 ! (S)-allantoin from urate: step 3/3
relationship: part_of UPa:UER00652 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 3/3

[Term]
id: UPa:UCR06782
name: 3-phenylpropanoate + H(+) + NADH + O(2) = NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
namespace: reaction
xref: KEGG:R06782 "KEGG reaction"
xref: METACYC:HCAMULTI-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20360 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC05629 ! 3-phenylpropanoate
relationship: has_input_compound UPa:UPC05629 {cardinality="1"} ! 3-phenylpropanoate
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
relationship: has_output_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
relationship: part_of UPa:UER00792 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2
relationship: part_of UPa:UER00792 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2

[Term]
id: UPa:UCR06784
name: NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
namespace: reaction
xref: KEGG:R06784 "KEGG reaction"
xref: METACYC:PHENPRODIOLDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:25065 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
relationship: has_input_compound UPa:UPC11588 ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: part_of UPa:UER00793 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2
relationship: part_of UPa:UER00793 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2

[Term]
id: UPa:UCR06786
name: 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)
namespace: reaction
xref: KEGG:R06786 "KEGG reaction"
xref: METACYC:MHPHYDROXY-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24788 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00004 ! NADH
relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC11457 {cardinality="1"} ! 3-(3-hydroxyphenyl)propanoate
relationship: has_input_compound UPa:UPC11457 ! 3-(3-hydroxyphenyl)propanoate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_output_compound UPa:UPC00003 ! NAD(+)
relationship: has_output_compound UPa:UPC04044 ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate
relationship: part_of UPa:UER00791 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1
relationship: part_of UPa:UER00791 ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1

[Term]
id: UPa:UCR06836
name: ATP + D-ribose 1,5-bisphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ADP
namespace: reaction
xref: KEGG:R06836 "KEGG reaction"
xref: METACYC:RXN0-1401 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:20112 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate
relationship: has_input_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: has_output_compound UPa:UPC00119 ! 5-phospho-alpha-D-ribose 1-diphosphate
relationship: part_of UPa:UER00175 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3
relationship: part_of UPa:UER00175 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3

[Term]
id: UPa:UCR06837
name: alpha-D-ribose 1-phosphate = D-ribose 1,5-bisphosphate
namespace: reaction
xref: KEGG:R06837 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate
relationship: has_input_compound UPa:UPC00620 ! alpha-D-ribose 1-phosphate
relationship: has_output_compound UPa:UPC01151 ! D-ribose 1,5-bisphosphate
relationship: has_output_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate
relationship: part_of UPa:UER00174 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3
relationship: part_of UPa:UER00174 ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3

[Term]
id: UPa:UCR06868
name: N-methylethanolamine phosphate + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + phosphodimethylethanolamine
namespace: reaction
xref: KEGG:R06868 "KEGG reaction"
xref: METACYC:RXN-5642 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25324 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate
relationship: has_input_compound UPa:UPC01210 ! N-methylethanolamine phosphate
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine
relationship: has_output_compound UPa:UPC13482 ! phosphodimethylethanolamine
relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1
relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="2"} ! phosphocholine from phosphoethanolamine: step 1/1

[Term]
id: UPa:UCR06869
name: S-adenosyl-L-methionine + phosphodimethylethanolamine = S-adenosyl-L-homocysteine + phosphocholine
namespace: reaction
xref: KEGG:R06869 "KEGG reaction"
xref: METACYC:RXN-5643 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25328 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine
relationship: has_input_compound UPa:UPC13482 ! phosphodimethylethanolamine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00588 ! phosphocholine
relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine
relationship: part_of UPa:UER00738 ! phosphocholine from phosphoethanolamine: step 1/1
relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="3"} ! phosphocholine from phosphoethanolamine: step 1/1

[Term]
id: UPa:UCR06895
name: 2 S-adenosyl-L-methionine + coproporphyrinogen-III = 2 5'-deoxyadenosine + 2 CO(2) + 2 L-methionine + protoporphyrinogen-IX
namespace: reaction
xref: KEGG:R06895 "KEGG reaction"
xref: METACYC:HEMN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15428 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III
relationship: has_input_compound UPa:UPC03263 ! coproporphyrinogen-III
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC01079 ! protoporphyrinogen-IX
relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX
relationship: has_output_compound UPa:UPC05198 ! 5'-deoxyadenosine
relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine
relationship: part_of UPa:UER00323 ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1
relationship: part_of UPa:UER00323 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1

[Term]
id: UPa:UCR06897
name: 2-hydroxy-hept-2,4-diene-1,7-dioic acid + H(2)O = 2,4-dihydroxyhept-2-enedioic acid
namespace: reaction
xref: KEGG:R06897 "KEGG reaction"
xref: RHEA:42075 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid
relationship: has_input_compound UPa:UPC05600 ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid
relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid
relationship: has_output_compound UPa:UPC06201 ! 2,4-dihydroxyhept-2-enedioic acid
relationship: part_of UPa:UER00421 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7
relationship: part_of UPa:UER00421 ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7

[Term]
id: UPa:UCR06974
name: ATP + N(1)-(5-phospho-D-ribosyl)glycinamide + formate = ADP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate
namespace: reaction
xref: KEGG:R06974 "KEGG reaction"
xref: METACYC:GARTRANSFORMYL2-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24832 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_input_compound UPa:UPC00058 ! formate
relationship: has_input_compound UPa:UPC03838 ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC04376 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
relationship: part_of UPa:UER00127 ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1
relationship: part_of UPa:UER00127 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1

[Term]
id: UPa:UCR06975
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
namespace: reaction
xref: KEGG:R06975 "KEGG reaction"
xref: METACYC:RXN-10066 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:24839 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_input_compound UPa:UPC00058 ! formate
relationship: has_input_compound UPa:UPC04677 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: has_output_compound UPa:UPC04734 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
relationship: part_of UPa:UER00134 ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1
relationship: part_of UPa:UER00134 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1

[Term]
id: UPa:UCR06977
name: L-aspartate 4-semialdehyde + L-glutamate = 2-oxoglutarate + L-2,4-diaminobutanoate
namespace: reaction
xref: KEGG:R06977 "KEGG reaction"
xref: METACYC:R101-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:11163 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde
relationship: has_input_compound UPa:UPC00441 ! L-aspartate 4-semialdehyde
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate
relationship: has_output_compound UPa:UPC03283 ! L-2,4-diaminobutanoate
relationship: part_of UPa:UER00121 ! L-ectoine from L-aspartate 4-semialdehyde: step 1/3
relationship: part_of UPa:UER00121 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 1/3
relationship: part_of UPa:UER00731 ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2
relationship: part_of UPa:UER00731 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2

[Term]
id: UPa:UCR06978
name: L-2,4-diaminobutanoate + acetyl-CoA = CoA + N(4)-acetyl-L-2,4-diaminobutyric acid
namespace: reaction
xref: KEGG:R06978 "KEGG reaction"
xref: METACYC:R102-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:16904 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC03283 ! L-2,4-diaminobutanoate
relationship: has_input_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid
relationship: has_output_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid
relationship: part_of UPa:UER00122 ! L-ectoine from L-aspartate 4-semialdehyde: step 2/3
relationship: part_of UPa:UER00122 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 2/3

[Term]
id: UPa:UCR06979
name: N(4)-acetyl-L-2,4-diaminobutyric acid = H(2)O + L-ectoine
namespace: reaction
xref: KEGG:R06979 "KEGG reaction"
xref: METACYC:R103-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:17284 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC06442 ! N(4)-acetyl-L-2,4-diaminobutyric acid
relationship: has_input_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC06231 {cardinality="1"} ! L-ectoine
relationship: has_output_compound UPa:UPC06231 ! L-ectoine
relationship: part_of UPa:UER00123 ! L-ectoine from L-aspartate 4-semialdehyde: step 3/3
relationship: part_of UPa:UER00123 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 3/3

[Term]
id: UPa:UCR06982
name: formaldehyde + glutathione = S-(hydroxymethyl)glutathione
namespace: reaction
xref: KEGG:R06982 "KEGG reaction"
xref: METACYC:RXN-2961 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22491 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00051 ! glutathione
relationship: has_input_compound UPa:UPC00051 {cardinality="1"} ! glutathione
relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde
relationship: has_input_compound UPa:UPC00067 ! formaldehyde
relationship: has_output_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione
relationship: has_output_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione
relationship: part_of UPa:UER00621 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 1/3
relationship: part_of UPa:UER00621 ! formate from formaldehyde (glutathione route): step 1/3

[Term]
id: UPa:UCR06983
name: NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione
namespace: reaction
xref: KEGG:R06983 "KEGG reaction"
xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:19988 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione
relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione
relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione
relationship: part_of UPa:UER00971 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00971 ! None

[Term]
id: UPa:UCR06987
name: 2-oxobutanoate + CoA = formate + propanoyl-CoA
namespace: reaction
xref: KEGG:R06987 "KEGG reaction"
xref: METACYC:KETOBUTFORMLY-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28057 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_input_compound UPa:UPC00010 ! CoA
relationship: has_input_compound UPa:UPC00109 ! 2-oxobutanoate
relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00100 ! propanoyl-CoA
relationship: has_output_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA
relationship: part_of UPa:UER00508 ! propanoate from L-threonine: step 2/4
relationship: part_of UPa:UER00508 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 2/4

[Term]
id: UPa:UCR06989
name: cis,cis-muconate = (S)-5-oxo-2,5-dihydro-2-furylacetic acid
namespace: reaction
xref: KEGG:R06989 "KEGG reaction"
xref: RHEA:30034 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate
relationship: has_input_compound UPa:UPC02480 ! cis,cis-muconate
relationship: has_output_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid
relationship: has_output_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid
relationship: part_of UPa:UER00259 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3
relationship: part_of UPa:UER00259 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3

[Term]
id: UPa:UCR06990
name: (S)-5-oxo-2,5-dihydro-2-furylacetic acid = 5-oxo-4,5-dihydro-2-furylacetate
namespace: reaction
xref: KEGG:R06990 "KEGG reaction"
xref: RHEA:12351 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid
relationship: has_input_compound UPa:UPC14610 ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid
relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: has_output_compound UPa:UPC03586 ! 5-oxo-4,5-dihydro-2-furylacetate
relationship: part_of UPa:UER00260 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3
relationship: part_of UPa:UER00260 ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3

[Term]
id: UPa:UCR07125
name: 3-dehydro-L-gulonate 6-phosphate + H(+) = CO(2) + L-xylulose 5-phosphate
namespace: reaction
xref: KEGG:R07125 "KEGG reaction"
xref: METACYC:RXN0-705 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14356 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC14899 ! 3-dehydro-L-gulonate 6-phosphate
relationship: has_input_compound UPa:UPC14899 {cardinality="1"} ! 3-dehydro-L-gulonate 6-phosphate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC03291 ! L-xylulose 5-phosphate
relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate
relationship: part_of UPa:UER00378 ! D-xylulose 5-phosphate from L-ascorbate: step 2/4
relationship: part_of UPa:UER00378 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 2/4

[Term]
id: UPa:UCR07133
name: D-sorbitol 6-phosphate + NAD(+) = D-fructose 6-phosphate + H(+) + NADH
namespace: reaction
xref: KEGG:R07133 "KEGG reaction"
xref: METACYC:SORB6PDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19840 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC01096 ! D-sorbitol 6-phosphate
relationship: has_input_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate
relationship: has_output_compound UPa:UPC00085 ! D-fructose 6-phosphate
relationship: part_of UPa:UER00783 ! D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1
relationship: part_of UPa:UER00783 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1

[Term]
id: UPa:UCR07136
name: (R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH
namespace: reaction
xref: KEGG:R07136 "KEGG reaction"
xref: METACYC:R230-RXN "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:15536 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate
relationship: has_input_compound UPa:UPC11537 ! (R)-3-sulfolactate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC05528 ! 3-sulfopyruvate
relationship: has_output_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate
relationship: part_of UPa:UER00471 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4
relationship: part_of UPa:UER00471 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4

[Term]
id: UPa:UCR07140
name: NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione
namespace: reaction
xref: KEGG:R07140 "KEGG reaction"
xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea"}
xref: RHEA:19984 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC14180 ! S-(hydroxymethyl)glutathione
relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC01031 ! S-formylglutathione
relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione
relationship: part_of UPa:UER00972 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00972 ! None

[Term]
id: UPa:UCR07170
name: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)
namespace: reaction
xref: KEGG:R07170 "KEGG reaction"
xref: METACYC:R-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10015 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC03043 {cardinality="1"} ! (R)-6-hydroxynicotine
relationship: has_input_compound UPa:UPC03043 ! (R)-6-hydroxynicotine
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC01297 ! 6-hydroxypseudooxynicotine
relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine
relationship: part_of UPa:UER00488 ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2
relationship: part_of UPa:UER00488 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2

[Term]
id: UPa:UCR07211
name: L-phenylalanine + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + L-tyrosine
namespace: reaction
xref: KEGG:R07211 "KEGG reaction"
xref: METACYC:PHENYLALANINE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:20276 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine
relationship: has_input_compound UPa:UPC00079 ! L-phenylalanine
relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine
relationship: has_output_compound UPa:UPC00082 ! L-tyrosine
relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin
relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin
relationship: part_of UPa:UER00337 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 1/6
relationship: part_of UPa:UER00337 ! acetoacetate and fumarate from L-phenylalanine: step 1/6

[Term]
id: UPa:UCR07213
name: L-tryptophan + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + 5-hydroxy-L-tryptophan
namespace: reaction
xref: KEGG:R07213 "KEGG reaction"
xref: METACYC:TRYPTOPHAN-5-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16712 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan
relationship: has_input_compound UPa:UPC00078 ! L-tryptophan
relationship: has_input_compound UPa:UPC00272 ! tetrahydrobiopterin
relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin
relationship: has_output_compound UPa:UPC00643 ! 5-hydroxy-L-tryptophan
relationship: has_output_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan
relationship: has_output_compound UPa:UPC15522 ! 4a-hydroxytetrahydrobiopterin
relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin
relationship: part_of UPa:UER00799 ! serotonin from L-tryptophan: step 1/2
relationship: part_of UPa:UER00799 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 1/2

[Term]
id: UPa:UCR07214
name: 1-aminocyclopropanecarboxylate + L-ascorbate + O(2) = CO(2) + 2 H(2)O + L-dehydroascorbate + ethylene + hydrogen cyanide
namespace: reaction
xref: KEGG:R07214 "KEGG reaction"
xref: METACYC:ETHYL-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:23643 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate
relationship: has_input_compound UPa:UPC00072 ! L-ascorbate
relationship: has_input_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate
relationship: has_input_compound UPa:UPC01234 ! 1-aminocyclopropanecarboxylate
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00177 ! hydrogen cyanide
relationship: has_output_compound UPa:UPC00177 {cardinality="1"} ! hydrogen cyanide
relationship: has_output_compound UPa:UPC05422 ! L-dehydroascorbate
relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate
relationship: has_output_compound UPa:UPC06547 {cardinality="1"} ! ethylene
relationship: has_output_compound UPa:UPC06547 ! ethylene
relationship: part_of UPa:UER00563 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 2/2
relationship: part_of UPa:UER00563 ! ethylene from S-adenosyl-L-methionine: step 2/2

[Term]
id: UPa:UCR07219
name: H(2)O + NADP(+) + dimethylallyl diphosphate = (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH
namespace: reaction
xref: KEGG:R07219 "KEGG reaction"
xref: METACYC:RXN0-884 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24828 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00235 ! dimethylallyl diphosphate
relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC11811 ! (2E)-4-hydroxy-3-methylbutenyl diphosphate
relationship: has_output_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate
relationship: part_of UPa:UER00105 ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1
relationship: part_of UPa:UER00105 {cardinality="1", direction="RL", order="1"} ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1

[Term]
id: UPa:UCR07243
name: S-adenosyl-L-methionine + sarcosine = N,N-dimethylglycine + S-adenosyl-L-homocysteine
namespace: reaction
xref: KEGG:R07243 "KEGG reaction"
xref: METACYC:RXN-9679 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:15456 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine
relationship: has_input_compound UPa:UPC00213 ! sarcosine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC01026 ! N,N-dimethylglycine
relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine
relationship: part_of UPa:UER00382 ! betaine from glycine: step 2/3
relationship: part_of UPa:UER00382 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 2/3

[Term]
id: UPa:UCR07244
name: N,N-dimethylglycine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + betaine
namespace: reaction
xref: KEGG:R07244 "KEGG reaction"
xref: METACYC:RXN-9680 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10075 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00019 ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine
relationship: has_input_compound UPa:UPC01026 ! N,N-dimethylglycine
relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine
relationship: has_output_compound UPa:UPC00021 ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine
relationship: has_output_compound UPa:UPC00719 ! betaine
relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine
relationship: part_of UPa:UER00383 ! betaine from glycine: step 3/3
relationship: part_of UPa:UER00383 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 3/3

[Term]
id: UPa:UCR07262
name: 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O = 1,4-dihydroxy-2-naphthoate + CoA
namespace: reaction
xref: KEGG:R07262 "KEGG reaction"
xref: METACYC:RXN-9311 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26312 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA
relationship: has_input_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC03657 ! 1,4-dihydroxy-2-naphthoate
relationship: has_output_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate
relationship: part_of UPa:UER01033 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7
relationship: part_of UPa:UER01033 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7

[Term]
id: UPa:UCR07263
name: 2-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O
namespace: reaction
xref: KEGG:R07263 "KEGG reaction"
xref: METACYC:NAPHTHOATE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:26565 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA
relationship: has_input_compound UPa:UPC03160 ! 2-succinylbenzoyl-CoA
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA
relationship: has_output_compound UPa:UPC15547 ! 1,4-dihydroxy-2-naphthoyl-CoA
relationship: part_of UPa:UER00167 ! 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7
relationship: part_of UPa:UER00167 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7

[Term]
id: UPa:UCR07276
name: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate
namespace: reaction
xref: KEGG:R07276 "KEGG reaction"
xref: METACYC:PREPHENATE-TRANSAMINE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22883 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate
relationship: has_input_compound UPa:UPC00826 ! L-arogenate
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00254 ! prephenate
relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate
relationship: part_of UPa:UER00343 ! L-arogenate from prephenate (L-Glu route): step 1/1
relationship: part_of UPa:UER00343 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Glu route): step 1/1

[Term]
id: UPa:UCR07280
name: 5-amino-6-(5-phosphoribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate
namespace: reaction
xref: KEGG:R07280 "KEGG reaction"
xref: METACYC:RIBOPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25200 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC04454 ! 5-amino-6-(5-phosphoribitylamino)uracil
relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC04732 ! 5-amino-6-(D-ribitylamino)uracil
relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil
relationship: part_of UPa:UER00403 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4
relationship: part_of UPa:UER00403 ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4

[Term]
id: UPa:UCR07281
name: D-ribulose 5-phosphate = 2-hydroxy-3-oxobutyl phosphate + formate
namespace: reaction
xref: KEGG:R07281 "KEGG reaction"
xref: METACYC:DIOHBUTANONEPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18460 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00199 ! D-ribulose 5-phosphate
relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC15556 ! 2-hydroxy-3-oxobutyl phosphate
relationship: has_output_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate
relationship: part_of UPa:UER00399 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1
relationship: part_of UPa:UER00399 ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1

[Term]
id: UPa:UCR07290
name: formyl-CoA + oxalate = formate + oxalyl-CoA
namespace: reaction
xref: KEGG:R07290 "KEGG reaction"
xref: METACYC:RXN0-1382 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:16548 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00209 ! oxalate
relationship: has_input_compound UPa:UPC00209 {cardinality="1"} ! oxalate
relationship: has_input_compound UPa:UPC00798 ! formyl-CoA
relationship: has_input_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA
relationship: has_output_compound UPa:UPC00313 ! oxalyl-CoA
relationship: part_of UPa:UER00598 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 1/2
relationship: part_of UPa:UER00598 ! CO(2) and formate from oxalate: step 1/2

[Term]
id: UPa:UCR07305
name: H(2)O + cyanurate = CO(2) + biuret
namespace: reaction
xref: KEGG:R07305 "KEGG reaction"
xref: METACYC:R468-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14644 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC06554 {cardinality="1"} ! cyanurate
relationship: has_input_compound UPa:UPC06554 ! cyanurate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC06555 ! biuret
relationship: has_output_compound UPa:UPC06555 {cardinality="1"} ! biuret
relationship: part_of UPa:UER00502 {cardinality="1", direction="LR", order="1"} ! biuret from cyanurate: step 1/1
relationship: part_of UPa:UER00502 ! biuret from cyanurate: step 1/1

[Term]
id: UPa:UCR07307
name: 2 H(2)O + dCTP = NH(3) + dUMP + diphosphate
namespace: reaction
xref: KEGG:R07307 "KEGG reaction"
xref: METACYC:3.5.4.30-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19208 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP
relationship: has_input_compound UPa:UPC00458 ! dCTP
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP
relationship: has_output_compound UPa:UPC00365 ! dUMP
relationship: part_of UPa:UER00667 ! dUMP from dCTP: step 1/1
relationship: part_of UPa:UER00667 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP: step 1/1

[Term]
id: UPa:UCR07320
name: violaxanthin = capsorubin
namespace: reaction
xref: KEGG:R07320 "KEGG reaction"
xref: METACYC:RXN-7946 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:21755 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC08614 ! violaxanthin
relationship: has_input_compound UPa:UPC08614 {cardinality="1"} ! violaxanthin
relationship: has_output_compound UPa:UPC08585 ! capsorubin
relationship: has_output_compound UPa:UPC08585 {cardinality="1"} ! capsorubin
relationship: part_of UPa:UER00775 ! capsorubin from violaxanthin: step 1/1
relationship: part_of UPa:UER00775 {cardinality="1", direction="LR", order="1"} ! capsorubin from violaxanthin: step 1/1

[Term]
id: UPa:UCR07321
name: antheraxanthin = capsanthin
namespace: reaction
xref: KEGG:R07321 "KEGG reaction"
xref: METACYC:RXN-7947 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:17376 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC08579 {cardinality="1"} ! antheraxanthin
relationship: has_input_compound UPa:UPC08579 ! antheraxanthin
relationship: has_output_compound UPa:UPC08584 ! capsanthin
relationship: has_output_compound UPa:UPC08584 {cardinality="1"} ! capsanthin
relationship: part_of UPa:UER00774 ! capsanthin from antheraxanthin: step 1/1
relationship: part_of UPa:UER00774 {cardinality="1", direction="LR", order="1"} ! capsanthin from antheraxanthin: step 1/1

[Term]
id: UPa:UCR07324
name: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate
namespace: reaction
xref: KEGG:R07324 "KEGG reaction"
xref: METACYC:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:10719 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00092 ! D-glucose 6-phosphate
relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate
relationship: has_output_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate
relationship: has_output_compound UPa:UPC04006 ! 1D-myo-inositol 3-phosphate
relationship: part_of UPa:UER00787 ! myo-inositol from D-glucose 6-phosphate: step 1/2
relationship: part_of UPa:UER00787 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 1/2

[Term]
id: UPa:UCR07364
name: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate
namespace: reaction
xref: KEGG:R07364 "KEGG reaction"
xref: METACYC:R147-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:24507 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
relationship: has_input_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
relationship: has_output_compound UPa:UPC00058 ! formate
relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate
relationship: has_output_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate
relationship: has_output_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate
relationship: part_of UPa:UER00878 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6
relationship: part_of UPa:UER00878 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6

[Term]
id: UPa:UCR07392
name: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O
namespace: reaction
xref: KEGG:R07392 "KEGG reaction"
xref: METACYC:R145-RXN "MetaCyc REACTION" {source="MetaCyc"}
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate
relationship: has_input_compound UPa:UPC04582 ! S-methyl-5-thio-D-ribulose 1-phosphate
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate
relationship: has_output_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate
relationship: part_of UPa:UER00875 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6
relationship: part_of UPa:UER00875 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6

[Term]
id: UPa:UCR07393
name: 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
namespace: reaction
xref: KEGG:R07393 "KEGG reaction"
xref: METACYC:R82-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:18772 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC15650 ! 5-(methylthio)-2,3-dioxopentyl phosphate
relationship: has_input_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate
relationship: has_output_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
relationship: has_output_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
relationship: part_of UPa:UER00876 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6
relationship: part_of UPa:UER00876 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6

[Term]
id: UPa:UCR07394
name: 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate
namespace: reaction
xref: KEGG:R07394 "KEGG reaction"
xref: METACYC:R83-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:14484 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC15651 ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
relationship: has_input_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC15606 ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
relationship: has_output_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
relationship: part_of UPa:UER00877 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6
relationship: part_of UPa:UER00877 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6

[Term]
id: UPa:UCR07396
name: 4-methylthio-2-oxobutanoate + L-glutamate = 2-oxoglutarate + L-methionine
namespace: reaction
xref: KEGG:R07396 "KEGG reaction"
xref: RHEA:25799 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate
relationship: has_input_compound UPa:UPC01180 ! 4-methylthio-2-oxobutanoate
relationship: has_output_compound UPa:UPC00026 ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate
relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine
relationship: has_output_compound UPa:UPC00073 ! L-methionine
relationship: part_of UPa:UER00879 ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6
relationship: part_of UPa:UER00879 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6

[Term]
id: UPa:UCR07399
name: H(2)O + acetyl-CoA + pyruvate = (R)-citramalate + CoA
namespace: reaction
xref: KEGG:R07399 "KEGG reaction"
xref: METACYC:RXN-7743 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19048 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00022 ! pyruvate
relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate
relationship: has_input_compound UPa:UPC00024 ! acetyl-CoA
relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA
relationship: has_output_compound UPa:UPC00010 ! CoA
relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA
relationship: has_output_compound UPa:UPC02612 ! (R)-citramalate
relationship: has_output_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate
relationship: part_of UPa:UER00066 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 1/3
relationship: part_of UPa:UER00066 ! 2-oxobutanoate from pyruvate: step 1/3

[Term]
id: UPa:UCR07403
name: H(+) + NADPH + O(2) + indole = H(2)O + NADP(+) + indolin-2-one
namespace: reaction
xref: KEGG:R07403 "KEGG reaction"
xref: METACYC:RXN-6681 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:31902 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole
relationship: has_input_compound UPa:UPC00463 ! indole
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one
relationship: has_output_compound UPa:UPC12312 ! indolin-2-one
relationship: part_of UPa:UER00848 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5
relationship: part_of UPa:UER00848 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5

[Term]
id: UPa:UCR07404
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate
namespace: reaction
xref: KEGG:R07404 "KEGG reaction"
xref: METACYC:RXN0-742 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19320 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00288 ! bicarbonate
relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate
relationship: has_input_compound UPa:UPC03373 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_output_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
relationship: part_of UPa:UER00942 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2
relationship: part_of UPa:UER00942 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2

[Term]
id: UPa:UCR07405
name: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
namespace: reaction
xref: KEGG:R07405 "KEGG reaction"
xref: METACYC:RXN0-743 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13196 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC15667 ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_input_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
relationship: has_output_compound UPa:UPC04751 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: has_output_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
relationship: part_of UPa:UER00943 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2
relationship: part_of UPa:UER00943 ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2

[Term]
id: UPa:UCR07406
name: 2-amino-3-oxo-4-phosphonooxybutyrate = 3-amino-2-oxopropyl phosphate + CO(2)
namespace: reaction
xref: KEGG:R07406 "KEGG reaction"
xref: METACYC:RXN-8447 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:25142 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC07335 ! 2-amino-3-oxo-4-phosphonooxybutyrate
relationship: has_input_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC11638 ! 3-amino-2-oxopropyl phosphate
relationship: has_output_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate
relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="2"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5
relationship: part_of UPa:UER00312 ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5

[Term]
id: UPa:UCR07407
name: L-aspartate + NADP(+) = H(+) + NADPH + iminoaspartate
namespace: reaction
xref: KEGG:R07407 "KEGG reaction"
xref: RHEA:42447 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate
relationship: has_output_compound UPa:UPC05840 ! iminoaspartate
relationship: part_of UPa:UER00964 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00964 ! None

[Term]
id: UPa:UCR07409
name: 2 H(+) + O(2) + choline + 2 reduced ferredoxin = 2 H(2)O + betaine aldehyde + 2 oxidized ferredoxin
namespace: reaction
xref: KEGG:R07409 "KEGG reaction"
xref: RHEA:17772 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline
relationship: has_input_compound UPa:UPC00114 ! choline
relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin
relationship: has_input_compound UPa:UPC00138 ! reduced ferredoxin
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00139 ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin
relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde
relationship: has_output_compound UPa:UPC00576 ! betaine aldehyde
relationship: part_of UPa:UER00430 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (monooxygenase route): step 1/1
relationship: part_of UPa:UER00430 ! betaine aldehyde from choline (monooxygenase route): step 1/1

[Term]
id: UPa:UCR07410
name: L-aspartate + NAD(+) = H(+) + NADH + iminoaspartate
namespace: reaction
xref: KEGG:R07410 "KEGG reaction"
xref: RHEA:42443 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate
relationship: has_input_compound UPa:UPC00049 ! L-aspartate
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC05840 ! iminoaspartate
relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate
relationship: part_of UPa:UER00963 ! None
relationship: part_of UPa:UER00963 {cardinality="1", direction="LR", order="1"} ! None

[Term]
id: UPa:UCR07411
name: H(2)O + farnesyl diphosphate + protoheme = diphosphate + heme O
namespace: reaction
xref: KEGG:R07411 "KEGG reaction"
xref: METACYC:HEMEOSYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"}
xref: RHEA:28073 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00032 {cardinality="1"} ! protoheme
relationship: has_input_compound UPa:UPC00032 ! protoheme
relationship: has_input_compound UPa:UPC00448 ! farnesyl diphosphate
relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate
relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate
relationship: has_output_compound UPa:UPC00013 ! diphosphate
relationship: has_output_compound UPa:UPC15672 ! heme O
relationship: has_output_compound UPa:UPC15672 {cardinality="1"} ! heme O
relationship: part_of UPa:UER00712 ! heme O from protoheme: step 1/1
relationship: part_of UPa:UER00712 {cardinality="1", direction="LR", order="1"} ! heme O from protoheme: step 1/1

[Term]
id: UPa:UCR07412
name: heme O = heme A
namespace: reaction
xref: KEGG:R07412 "KEGG reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC15672 {cardinality="1"} ! heme O
relationship: has_input_compound UPa:UPC15672 ! heme O
relationship: has_output_compound UPa:UPC15670 ! heme A
relationship: has_output_compound UPa:UPC15670 {cardinality="1"} ! heme A
relationship: part_of UPa:UER00713 ! heme A from heme O: step 1/1
relationship: part_of UPa:UER00713 {cardinality="1", direction="LR", order="1"} ! heme A from heme O: step 1/1

[Term]
id: UPa:UCR07414
name: ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + phosphate
namespace: reaction
xref: KEGG:R07414 "KEGG reaction"
xref: METACYC:RXN0-3901 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:13636 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP
relationship: has_input_compound UPa:UPC00002 ! ATP
relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_input_compound UPa:UPC00025 ! L-glutamate
relationship: has_input_compound UPa:UPC00134 ! putrescine
relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine
relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP
relationship: has_output_compound UPa:UPC00008 ! ADP
relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate
relationship: has_output_compound UPa:UPC00009 ! phosphate
relationship: has_output_compound UPa:UPC15699 ! gamma-L-glutamylputrescine
relationship: has_output_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine
relationship: part_of UPa:UER00880 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 1/4
relationship: part_of UPa:UER00880 ! 4-aminobutanoate from putrescine: step 1/4

[Term]
id: UPa:UCR07415
name: H(2)O + O(2) + gamma-L-glutamylputrescine = H(2)O(2) + NH(3) + gamma-glutamyl-4-aminobutanal
namespace: reaction
xref: KEGG:R07415 "KEGG reaction"
xref: RHEA:28417 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC15699 ! gamma-L-glutamylputrescine
relationship: has_input_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine
relationship: has_output_compound UPa:UPC00014 ! NH(3)
relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3)
relationship: has_output_compound UPa:UPC00027 ! H(2)O(2)
relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2)
relationship: has_output_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal
relationship: has_output_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal
relationship: part_of UPa:UER00881 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 2/4
relationship: part_of UPa:UER00881 ! 4-aminobutanoate from putrescine: step 2/4

[Term]
id: UPa:UCR07417
name: H(2)O + NAD(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADH
namespace: reaction
xref: KEGG:R07417 "KEGG reaction"
xref: RHEA:42343 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+)
relationship: has_input_compound UPa:UPC00003 ! NAD(+)
relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal
relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal
relationship: has_output_compound UPa:UPC00004 ! NADH
relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: part_of UPa:UER00989 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00989 ! None

[Term]
id: UPa:UCR07418
name: H(2)O + NADP(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADPH
namespace: reaction
xref: KEGG:R07418 "KEGG reaction"
xref: METACYC:RXN0-3922 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:28413 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC15700 ! gamma-glutamyl-4-aminobutanal
relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: has_output_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: part_of UPa:UER00990 {cardinality="1", direction="LR", order="1"} ! None
relationship: part_of UPa:UER00990 ! None

[Term]
id: UPa:UCR07419
name: 4-(L-gamma-glutamylamino)butanoic acid + H(2)O = 4-aminobutanoate + L-glutamate
namespace: reaction
xref: KEGG:R07419 "KEGG reaction"
xref: METACYC:RXN0-3942 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:19740 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_input_compound UPa:UPC00001 ! H(2)O
relationship: has_input_compound UPa:UPC15767 ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: has_input_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid
relationship: has_output_compound UPa:UPC00025 ! L-glutamate
relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate
relationship: has_output_compound UPa:UPC00334 ! 4-aminobutanoate
relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate
relationship: part_of UPa:UER00883 ! 4-aminobutanoate from putrescine: step 4/4
relationship: part_of UPa:UER00883 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 4/4

[Term]
id: UPa:UCR07421
name: H(+) + NADPH + O(2) + indolin-2-one = 3-hydroxyindolin-2-one + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R07421 "KEGG reaction"
xref: METACYC:RXN-6682 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:31922 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC12312 ! indolin-2-one
relationship: has_input_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one
relationship: has_output_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one
relationship: part_of UPa:UER00849 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5
relationship: part_of UPa:UER00849 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5

[Term]
id: UPa:UCR07422
name: 3-hydroxyindolin-2-one + H(+) + NADPH + O(2) = 2-hydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R07422 "KEGG reaction"
xref: METACYC:RXN-6683 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:31930 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC11130 ! 3-hydroxyindolin-2-one
relationship: has_input_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one
relationship: has_output_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one
relationship: part_of UPa:UER00850 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5
relationship: part_of UPa:UER00850 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5

[Term]
id: UPa:UCR07423
name: 2-hydroxy-1,4-benzoxazin-3-one + H(+) + NADPH + O(2) = 2,4-dihydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+)
namespace: reaction
xref: KEGG:R07423 "KEGG reaction"
xref: METACYC:RXN-6684 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:31942 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2)
relationship: has_input_compound UPa:UPC00007 ! O(2)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one
relationship: has_input_compound UPa:UPC15769 ! 2-hydroxy-1,4-benzoxazin-3-one
relationship: has_output_compound UPa:UPC00001 ! H(2)O
relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC15770 ! 2,4-dihydroxy-1,4-benzoxazin-3-one
relationship: has_output_compound UPa:UPC15770 {cardinality="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one
relationship: part_of UPa:UER00851 ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5
relationship: part_of UPa:UER00851 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5

[Term]
id: UPa:UCR07476
name: (2R)-O-phospho-3-sulfolactic acid = phosphoenolpyruvate + sulfite
namespace: reaction
xref: KEGG:R07476 "KEGG reaction"
xref: METACYC:4.4.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:22787 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid
relationship: has_input_compound UPa:UPC11536 ! (2R)-O-phospho-3-sulfolactic acid
relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC00074 ! phosphoenolpyruvate
relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite
relationship: has_output_compound UPa:UPC00094 ! sulfite
relationship: part_of UPa:UER00469 {cardinality="1", direction="RL", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4
relationship: part_of UPa:UER00469 ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4

[Term]
id: UPa:UCR07494
name: 4alpha-methylzymosterol-4-carboxylic acid + NADP(+) = 3-dehydro-4-methylzymosterol + CO(2) + H(+) + NADPH
namespace: reaction
xref: KEGG:R07494 "KEGG reaction"
xref: METACYC:RXN66-313 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:33450 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00006 ! NADP(+)
relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_input_compound UPa:UPC15808 ! 4alpha-methylzymosterol-4-carboxylic acid
relationship: has_input_compound UPa:UPC15808 {cardinality="1"} ! 4alpha-methylzymosterol-4-carboxylic acid
relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_output_compound UPa:UPC00005 ! NADPH
relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2)
relationship: has_output_compound UPa:UPC00011 ! CO(2)
relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_output_compound UPa:UPC00080 ! H(+)
relationship: has_output_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol
relationship: has_output_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol
relationship: part_of UPa:UER00757 ! zymosterol from lanosterol: step 4/6
relationship: part_of UPa:UER00757 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 4/6

[Term]
id: UPa:UCR07495
name: 3-dehydro-4-methylzymosterol + H(+) + NADPH = 4-alpha-methylzymosterol + NADP(+)
namespace: reaction
xref: KEGG:R07495 "KEGG reaction"
xref: METACYC:RXN66-314 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:36382 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC00005 ! NADPH
relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH
relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+)
relationship: has_input_compound UPa:UPC00080 ! H(+)
relationship: has_input_compound UPa:UPC15816 ! 3-dehydro-4-methylzymosterol
relationship: has_input_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol
relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+)
relationship: has_output_compound UPa:UPC00006 ! NADP(+)
relationship: has_output_compound UPa:UPC05103 ! 4-alpha-methylzymosterol
relationship: has_output_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol
relationship: part_of UPa:UER00758 ! zymosterol from lanosterol: step 5/6
relationship: part_of UPa:UER00758 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 5/6

[Term]
id: UPa:UCR07496
name: 4-alpha-methylzymosterol = zymosterol
namespace: reaction
xref: KEGG:R07496 "KEGG reaction"
xref: RHEA:42459 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC05103 ! 4-alpha-methylzymosterol
relationship: has_input_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol
relationship: has_output_compound UPa:UPC05437 {cardinality="1"} ! zymosterol
relationship: has_output_compound UPa:UPC05437 ! zymosterol
relationship: part_of UPa:UER00759 ! zymosterol from lanosterol: step 6/6
relationship: part_of UPa:UER00759 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 6/6

[Term]
id: UPa:UCR07497
name: fecosterol = episterol
namespace: reaction
xref: KEGG:R07497 "KEGG reaction"
xref: METACYC:RXN3O-203 "MetaCyc REACTION" {source="MetaCyc"}
xref: RHEA:33438 "Rhea reaction"
is_a: BFO:0000015 ! process
is_a: UPa:UCR00000 ! reaction
relationship: has_input_compound UPa:UPC04525 {cardinality="1"