format-version: 1.2 data-version: releases/2018-12-12 date: 21:07:2015 00:00 saved-by: anne.morgat@isb-sib.ch synonymtypedef: FORMULA "FORMULA" synonymtypedef: InChI "InChI" default-namespace: unipathway_ontology remark: UniPathway Release 2015_03 ontology: upa [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] disjoint_from: BFO:0000003 ! occurrent [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] is_a: BFO:0000002 ! continuant [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant [Term] id: GO:0003674 name: molecular_function is_a: BFO:0000015 ! process property_value: IAO:0000589 "molecular process" xsd:string [Term] id: GO:0003824 name: catalytic activity is_a: GO:0003674 ! molecular_function [Term] id: GO:0008150 name: biological_process is_a: BFO:0000015 ! process [Term] id: GO:0016301 name: kinase activity is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016740 name: transferase activity is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups is_a: GO:0016740 ! transferase activity [Term] id: UPa:UCR00000 name: reaction namespace: reaction def: "A chemical reaction involved in a UniPathway pathway." [] [Term] id: UPa:UCR00005 name: H(2)O + urea-1-carboxylate = 2 CO(2) + 2 NH(3) namespace: reaction xref: KEGG:R00005 "KEGG reaction" xref: METACYC:ALLOPHANATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19032 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: part_of UPa:UER00372 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 2/2 [Term] id: UPa:UCR00010 name: H(2)O + alpha,alpha-trehalose = 2 D-glucose namespace: reaction xref: KEGG:R00010 "KEGG reaction" xref: METACYC:TREHALA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20871 "Rhea reaction" xref: RHEA:32678 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01083 {cardinality="1"} ! alpha,alpha-trehalose relationship: has_output_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: part_of UPa:UER00535 {cardinality="1", direction="LR", order="1"} ! D-glucose from alpha,alpha-trehalose: step 1/1 [Term] id: UPa:UCR00013 name: 2 glyoxylate = 2-hydroxy-3-oxopropanoate + CO(2) namespace: reaction xref: KEGG:R00013 "KEGG reaction" xref: METACYC:GLYOCARBOLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10139 "Rhea reaction" relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00831 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 2/4 [Term] id: UPa:UCR00014 name: pyruvate + thiamine diphosphate = 2-hydroxyethyl-ThPP + CO(2) namespace: reaction xref: KEGG:R00014 "KEGG reaction" xref: METACYC:RXN-12583 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: part_of UPa:UER00059 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 1/4 [Term] id: UPa:UCR00021 name: 2 L-glutamate + 2 oxidized ferredoxin = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced ferredoxin namespace: reaction xref: KEGG:R00021 "KEGG reaction" xref: METACYC:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12131 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: part_of UPa:UER00691 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1 [Term] id: UPa:UCR00036 name: 2 5-aminolevulinate = 2 H(2)O + porphobilinogen namespace: reaction xref: KEGG:R00036 "KEGG reaction" xref: METACYC:PORPHOBILSYNTH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24067 "Rhea reaction" relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen relationship: part_of UPa:UER00318 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 1/4 [Term] id: UPa:UCR00066 name: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = 5-amino-6-(D-ribitylamino)uracil + riboflavin namespace: reaction xref: KEGG:R00066 "KEGG reaction" xref: METACYC:RIBOFLAVIN-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20775 "Rhea reaction" relationship: has_input_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: has_output_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:UER00405 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2 [Term] id: UPa:UCR00084 name: H(2)O + 4 porphobilinogen = 4 NH(3) + hydroxymethylbilane namespace: reaction xref: KEGG:R00084 "KEGG reaction" xref: METACYC:OHMETHYLBILANESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13188 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00931 {cardinality="1"} ! porphobilinogen relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane relationship: part_of UPa:UER00319 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 2/4 [Term] id: UPa:UCR00093 name: 2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH namespace: reaction xref: KEGG:R00093 "KEGG reaction" xref: METACYC:GLUTAMATE-SYNTHASE-NADH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13756 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00690 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1 [Term] id: UPa:UCR00114 name: 2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH namespace: reaction xref: KEGG:R00114 "KEGG reaction" xref: METACYC:GLUTAMATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15504 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00689 {cardinality="1", direction="RL", order="1"} ! L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1 [Term] id: UPa:UCR00127 name: AMP + ATP = 2 ADP namespace: reaction xref: KEGG:R00127 "KEGG reaction" xref: METACYC:ADENYL-KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12976 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: part_of UPa:UER00649 {cardinality="1", direction="RL", order="1"} ! AMP from ADP: step 1/1 [Term] id: UPa:UCR00130 name: 3'-dephospho-CoA + ATP = ADP + CoA namespace: reaction xref: KEGG:R00130 "KEGG reaction" xref: METACYC:DEPHOSPHOCOAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18248 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: part_of UPa:UER00356 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 5/5 [Term] id: UPa:UCR00131 name: H(2)O + urea = CO(2) + 2 NH(3) namespace: reaction xref: KEGG:R00131 "KEGG reaction" xref: METACYC:UREASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20560 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: part_of UPa:UER00370 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (urease route): step 1/1 [Term] id: UPa:UCR00137 name: ATP + nicotinamide D-ribonucleotide = NAD(+) + diphosphate namespace: reaction xref: KEGG:R00137 "KEGG reaction" xref: METACYC:2.7.7.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21363 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: part_of UPa:UER00600 {cardinality="1", direction="LR", order="1"} ! NAD(+) from nicotinamide D-ribonucleotide: step 1/1 [Term] id: UPa:UCR00150 name: ATP + CO(2) + NH(3) = ADP + carbamoyl phosphate namespace: reaction xref: KEGG:R00150 "KEGG reaction" xref: METACYC:CARBAMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10155 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: part_of UPa:UER00366 {cardinality="1", direction="RL", order="1"} ! CO(2) and NH(3) from carbamoyl phosphate: step 1/1 [Term] id: UPa:UCR00156 name: ATP + UDP = ADP + UTP namespace: reaction xref: KEGG:R00156 "KEGG reaction" xref: METACYC:UDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25101 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: part_of UPa:UER00276 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 1/2 [Term] id: UPa:UCR00158 name: ATP + UMP = ADP + UDP namespace: reaction xref: KEGG:R00158 "KEGG reaction" xref: METACYC:RXN-12002 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24403 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: part_of UPa:UER00274 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMK/CMK route): step 1/1 relationship: part_of UPa:UER00275 {cardinality="1", direction="LR", order="1"} ! UDP from UMP (UMPK route): step 1/1 [Term] id: UPa:UCR00161 name: ATP + FMN = FAD + diphosphate namespace: reaction xref: KEGG:R00161 "KEGG reaction" xref: METACYC:FADSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17240 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: part_of UPa:UER00407 {cardinality="1", direction="LR", order="1"} ! FAD from FMN: step 1/1 [Term] id: UPa:UCR00173 name: H(2)O + pyridoxal 5'-phosphate = phosphate + pyridoxal namespace: reaction xref: KEGG:R00173 "KEGG reaction" xref: METACYC:3.1.3.74-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20536 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00301 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxal 5'-phosphate: step 1/1 [Term] id: UPa:UCR00174 name: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00174 "KEGG reaction" xref: METACYC:PYRIDOXKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10227 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: part_of UPa:UER00298 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxal: step 1/1 [Term] id: UPa:UCR00177 name: S-adenosyl-L-methionine + diphosphate + phosphate = ATP + H(2)O + L-methionine namespace: reaction xref: KEGG:R00177 "KEGG reaction" xref: METACYC:S-ADENMETSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21083 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: part_of UPa:UER00080 {cardinality="1", direction="RL", order="1"} ! S-adenosyl-L-methionine from L-methionine: step 1/1 [Term] id: UPa:UCR00178 name: H(+) + S-adenosyl-L-methionine = CO(2) + S-adenosylmethioninamine namespace: reaction xref: KEGG:R00178 "KEGG reaction" xref: METACYC:SAMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15984 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: part_of UPa:UER00451 {cardinality="1", direction="LR", order="1"} ! S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1 [Term] id: UPa:UCR00179 name: S-adenosyl-L-methionine = 1-aminocyclopropanecarboxylate + S-methyl-5'-thioadenosine namespace: reaction xref: KEGG:R00179 "KEGG reaction" xref: METACYC:4.4.1.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21747 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate relationship: part_of UPa:UER00562 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 1/2 [Term] id: UPa:UCR00181 name: AMP + H(2)O = IMP + NH(3) namespace: reaction xref: KEGG:R00181 "KEGG reaction" xref: METACYC:AMP-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14780 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UER00663 {cardinality="1", direction="LR", order="1"} ! IMP from AMP: step 1/1 [Term] id: UPa:UCR00185 name: ATP + adenosine = ADP + AMP namespace: reaction xref: KEGG:R00185 "KEGG reaction" xref: METACYC:ADENOSINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20827 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00212 {cardinality="1"} ! adenosine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UER00659 {cardinality="1", direction="LR", order="1"} ! AMP from adenosine: step 1/1 [Term] id: UPa:UCR00189 name: ATP + NH(3) + deamido-NAD(+) = AMP + NAD(+) + diphosphate namespace: reaction xref: KEGG:R00189 "KEGG reaction" xref: METACYC:NAD-SYNTH-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21191 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UER00333 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (ammonia route): step 1/1 [Term] id: UPa:UCR00190 name: AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine namespace: reaction xref: KEGG:R00190 "KEGG reaction" xref: METACYC:ADENPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16612 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: part_of UPa:UER00646 {cardinality="1", direction="RL", order="1"} ! AMP from adenine: step 1/1 [Term] id: UPa:UCR00191 name: 3',5'-cyclic AMP + H(2)O = AMP namespace: reaction xref: KEGG:R00191 "KEGG reaction" xref: METACYC:RXN0-5038 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25280 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00575 {cardinality="1"} ! 3',5'-cyclic AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: part_of UPa:UER00747 {cardinality="1", direction="LR", order="1"} ! AMP from 3',5'-cyclic AMP: step 1/1 [Term] id: UPa:UCR00192 name: H(2)O + S-adenosyl-L-homocysteine = L-homocysteine + adenosine namespace: reaction xref: KEGG:R00192 "KEGG reaction" xref: METACYC:ADENOSYLHOMOCYSTEINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21711 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00212 {cardinality="1"} ! adenosine relationship: part_of UPa:UER00076 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from S-adenosyl-L-homocysteine: step 1/1 [Term] id: UPa:UCR00200 name: ATP + pyruvate = ADP + phosphoenolpyruvate namespace: reaction xref: KEGG:R00200 "KEGG reaction" xref: METACYC:PEPDEPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18160 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: part_of UPa:UER00188 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 5/5 [Term] id: UPa:UCR00212 name: acetyl-CoA + formate = CoA + pyruvate namespace: reaction xref: KEGG:R00212 "KEGG reaction" xref: METACYC:PYRUVFORMLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11847 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UER00891 {cardinality="1", direction="RL", order="1"} ! formate from pyruvate: step 1/1 [Term] id: UPa:UCR00226 name: (S)-2-acetolactate + CO(2) = 2 pyruvate namespace: reaction xref: KEGG:R00226 "KEGG reaction" xref: METACYC:ACETOLACTSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25252 "Rhea reaction" relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: part_of UPa:UER00677 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 1/3 [Term] id: UPa:UCR00228 name: CoA + NAD(+) + acetaldehyde = H(+) + NADH + acetyl-CoA namespace: reaction xref: KEGG:R00228 "KEGG reaction" xref: METACYC:ACETALD-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23291 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00798 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetaldehyde: step 1/1 [Term] id: UPa:UCR00230 name: acetyl-CoA + phosphate = CoA + acetyl phosphate namespace: reaction xref: KEGG:R00230 "KEGG reaction" xref: METACYC:PHOSACETYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19524 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: part_of UPa:UER00459 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA from acetate: step 2/2 [Term] id: UPa:UCR00233 name: malonyl-CoA = CO(2) + acetyl-CoA namespace: reaction xref: KEGG:R00233 "KEGG reaction" xref: METACYC:MALONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18784 "Rhea reaction" relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: part_of UPa:UER00710 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from malonyl-CoA: step 1/1 [Term] id: UPa:UCR00238 name: 2 acetyl-CoA = CoA + acetoacetyl-CoA namespace: reaction xref: KEGG:R00238 "KEGG reaction" xref: METACYC:ACETYL-COA-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21039 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: part_of UPa:UER00101 {cardinality="1", direction="LR", order="1"} ! (R)-mevalonate from acetyl-CoA: step 1/3 [Term] id: UPa:UCR00239 name: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate namespace: reaction xref: KEGG:R00239 "KEGG reaction" xref: METACYC:GLUTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14880 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate relationship: part_of UPa:UER00359 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 1/2 [Term] id: UPa:UCR00243 name: H(2)O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH(3) namespace: reaction xref: KEGG:R00243 "KEGG reaction" xref: METACYC:GLUTAMATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15136 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00591 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 1/5 [Term] id: UPa:UCR00253 name: ATP + L-glutamate + NH(3) = ADP + L-glutamine + phosphate namespace: reaction xref: KEGG:R00253 "KEGG reaction" xref: METACYC:GLUTAMINESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16172 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: part_of UPa:UER01025 {cardinality="1", direction="LR", order="1"} ! L-glutamine from L-glutamate: step 1/1 [Term] id: UPa:UCR00256 name: H(2)O + L-glutamine = L-glutamate + NH(3) namespace: reaction xref: KEGG:R00256 "KEGG reaction" xref: METACYC:GLUTAMIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15892 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 1/5 relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="2"} ! 4-aminobenzoate from chorismate: step 1/2 [Term] id: UPa:UCR00257 name: ATP + H(2)O + L-glutamine + deamido-NAD(+) = AMP + L-glutamate + NAD(+) + diphosphate namespace: reaction xref: KEGG:R00257 "KEGG reaction" xref: METACYC:NAD-SYNTH-GLN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24387 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UER00334 {cardinality="1", direction="LR", order="1"} ! NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1 [Term] id: UPa:UCR00258 name: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate namespace: reaction xref: KEGG:R00258 "KEGG reaction" xref: METACYC:ALANINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19456 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UER00586 {cardinality="1", direction="LR", order="1"} ! pyruvate from L-alanine: step 1/1 [Term] id: UPa:UCR00259 name: L-glutamate + acetyl-CoA = CoA + N-acetyl-L-glutamate namespace: reaction xref: KEGG:R00259 "KEGG reaction" xref: METACYC:N-ACETYLTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24295 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: part_of UPa:UER00106 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 1/4 [Term] id: UPa:UCR00262 name: (2S,3S)-3-methyl-L-aspartate = L-glutamate namespace: reaction xref: KEGG:R00262 "KEGG reaction" xref: METACYC:METHYLASPARTATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12860 "Rhea reaction" relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: part_of UPa:UER00617 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 1/4 [Term] id: UPa:UCR00264 name: 2,5-dioxopentanoate + H(2)O + NADP(+) = 2-oxoglutarate + H(+) + NADPH namespace: reaction xref: KEGG:R00264 "KEGG reaction" xref: METACYC:25-DIOXOVALERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11299 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00573 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 2/2 [Term] id: UPa:UCR00267 name: NADP(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R00267 "KEGG reaction" xref: METACYC:ISOCITDEH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-8642 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:19632 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00995 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NADP(+) route): step 1/1 [Term] id: UPa:UCR00271 name: 2-oxoglutarate + H(2)O + acetyl-CoA = (R)-homocitrate + CoA namespace: reaction xref: KEGG:R00271 "KEGG reaction" xref: METACYC:HOMOCITRATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12932 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate relationship: part_of UPa:UER00028 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 1/5 [Term] id: UPa:UCR00272 name: 2-oxoglutarate = CO(2) + succinate semialdehyde namespace: reaction xref: KEGG:R00272 "KEGG reaction" xref: METACYC:RXN-7774 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10527 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: part_of UPa:UER01001 {cardinality="1", direction="LR", order="1"} ! succinate from 2-oxoglutarate (transferase route): step 1/2 [Term] id: UPa:UCR00277 name: H(2)O + O(2) + pyridoxamine 5'-phosphate = H(2)O(2) + NH(3) + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00277 "KEGG reaction" xref: METACYC:PMPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15820 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: part_of UPa:UER00304 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1 [Term] id: UPa:UCR00278 name: O(2) + pyridoxine 5'-phosphate = H(2)O(2) + pyridoxal 5'-phosphate namespace: reaction xref: KEGG:R00278 "KEGG reaction" xref: METACYC:PNPOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15152 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: has_output_compound UPa:UPC00018 {cardinality="1"} ! pyridoxal 5'-phosphate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: part_of UPa:UER00305 {cardinality="1", direction="LR", order="1"} ! pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1 [Term] id: UPa:UCR00286 name: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 2 H(+) + 2 NADH + UDP-alpha-D-glucuronate namespace: reaction xref: KEGG:R00286 "KEGG reaction" xref: METACYC:UGD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23599 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: part_of UPa:UER00491 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1 [Term] id: UPa:UCR00294 name: 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide = H(2)O + 2 ferricytochrome c + nitrous oxide namespace: reaction xref: KEGG:R00294 "KEGG reaction" xref: METACYC:NITRIC-OXIDE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10991 "Rhea reaction" xref: RHEA:30214 "Rhea reaction" relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide relationship: part_of UPa:UER00708 {cardinality="1", direction="LR", order="1"} ! dinitrogen from nitrate: step 3/4 [Term] id: UPa:UCR00299 name: ATP + D-glucose = ADP + D-glucose 6-phosphate namespace: reaction xref: KEGG:R00299 "KEGG reaction" xref: METACYC:GLUCOKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17828 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: part_of UPa:UER00180 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4 [Term] id: UPa:UCR00310 name: Fe2+ + protoporphyrin-IX = 2 H(+) + protoheme namespace: reaction xref: KEGG:R00310 "KEGG reaction" xref: METACYC:PROTOHEMEFERROCHELAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22587 "Rhea reaction" relationship: has_input_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: has_input_compound UPa:UPC14818 {cardinality="1"} ! Fe2+ relationship: has_output_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00325 {cardinality="1", direction="LR", order="1"} ! protoheme from protoporphyrin-IX: step 1/1 [Term] id: UPa:UCR00315 name: ATP + acetate = ADP + acetyl phosphate namespace: reaction xref: KEGG:R00315 "KEGG reaction" xref: METACYC:ACETATEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11355 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: part_of UPa:UER00458 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from acetate: step 1/2 [Term] id: UPa:UCR00325 name: L-citramalate = acetate + pyruvate namespace: reaction xref: KEGG:R00325 "KEGG reaction" xref: METACYC:CITRAMALATE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15548 "Rhea reaction" relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: part_of UPa:UER00620 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 4/4 [Term] id: UPa:UCR00336 name: H(2)O + ppGpp = GDP + diphosphate namespace: reaction xref: KEGG:R00336 "KEGG reaction" xref: METACYC:PPGPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14256 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: part_of UPa:UER00886 {cardinality="1", direction="RL", order="1"} ! ppGpp from GDP: step 1/1 [Term] id: UPa:UCR00342 name: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate namespace: reaction xref: KEGG:R00342 "KEGG reaction" xref: METACYC:MALATE-DEH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21435 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00721 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate: step 1/1 [Term] id: UPa:UCR00351 name: CoA + citrate = H(2)O + acetyl-CoA + oxaloacetate namespace: reaction xref: KEGG:R00351 "KEGG reaction" xref: METACYC:CITSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16848 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: part_of UPa:UER00717 {cardinality="1", direction="RL", order="1"} ! isocitrate from oxaloacetate: step 1/2 [Term] id: UPa:UCR00355 name: 2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate namespace: reaction xref: KEGG:R00355 "KEGG reaction" xref: METACYC:ASPAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21827 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: part_of UPa:UER01024 {cardinality="1", direction="RL", order="1"} ! L-aspartate from oxaloacetate: step 1/1 [Term] id: UPa:UCR00361 name: (S)-malate + Quinone = Hydroquinone + oxaloacetate namespace: reaction xref: KEGG:R00361 "KEGG reaction" xref: METACYC:MALATE-DEHYDROGENASE-ACCEPTOR-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22559 "Rhea reaction" relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER01008 {cardinality="1", direction="LR", order="1"} ! oxaloacetate from (S)-malate (quinone route): step 1/1 [Term] id: UPa:UCR00367 name: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine namespace: reaction xref: KEGG:R00367 "KEGG reaction" xref: METACYC:GLYCINE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19940 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UER00381 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 1/3 [Term] id: UPa:UCR00369 name: L-alanine + glyoxylate = glycine + pyruvate namespace: reaction xref: KEGG:R00369 "KEGG reaction" xref: METACYC:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24251 "Rhea reaction" relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_input_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: part_of UPa:UER00428 {cardinality="1", direction="LR", order="1"} ! glycine from glyoxylate: step 1/1 [Term] id: UPa:UCR00371 name: acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoic acid namespace: reaction xref: KEGG:R00371 "KEGG reaction" xref: METACYC:AKBLIG-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:20739 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid relationship: part_of UPa:UER00506 {cardinality="1", direction="RL", order="1"} ! glycine from L-threonine: step 2/2 [Term] id: UPa:UCR00372 name: 2-oxoglutarate + glycine = L-glutamate + glyoxylate namespace: reaction xref: KEGG:R00372 "KEGG reaction" xref: METACYC:GLYCINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14092 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00913 {cardinality="1", direction="RL", order="1"} ! glycine from 2-phosphoglycolate: step 3/3 [Term] id: UPa:UCR00396 name: H(2)O + L-alanine + NAD(+) = H(+) + NADH + NH(3) + pyruvate namespace: reaction xref: KEGG:R00396 "KEGG reaction" xref: METACYC:ALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18408 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00585 {cardinality="1", direction="LR", order="1"} ! NH(3) and pyruvate from L-alanine: step 1/1 [Term] id: UPa:UCR00401 name: L-alanine = D-alanine namespace: reaction xref: KEGG:R00401 "KEGG reaction" xref: METACYC:ALARACECAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20252 "Rhea reaction" relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: part_of UPa:UER00497 {cardinality="1", direction="LR", order="1"} ! D-alanine from L-alanine: step 1/1 [Term] id: UPa:UCR00405 name: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA namespace: reaction xref: KEGG:R00405 "KEGG reaction" xref: METACYC:SUCCCOASYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17664 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UER00999 {cardinality="1", direction="RL", order="1"} ! succinate from succinyl-CoA (ligase route): step 1/1 [Term] id: UPa:UCR00410 name: acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate namespace: reaction xref: KEGG:R00410 "KEGG reaction" xref: METACYC:RXNI-2 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25483 "Rhea reaction" relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: part_of UPa:UER00894 {cardinality="1", direction="LR", order="1"} ! acetoacetyl-CoA from succinyl-CoA: step 1/1 relationship: part_of UPa:UER01000 {cardinality="1", direction="LR", order="1"} ! succinate from succinyl-CoA (transferase route): step 1/1 [Term] id: UPa:UCR00411 name: H(2)O + N(2)-succinyl-L-glutamic acid = L-glutamate + succinate namespace: reaction xref: KEGG:R00411 "KEGG reaction" xref: METACYC:SUCCGLUDESUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15172 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: part_of UPa:UER00283 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 5/5 [Term] id: UPa:UCR00412 name: acceptor + succinate = fumarate + reduced acceptor namespace: reaction xref: KEGG:R00412 "KEGG reaction" xref: RHEA:16360 "Rhea reaction" relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER01005 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (bacterial route): step 1/1 [Term] id: UPa:UCR00416 name: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = UDP-N-acetyl-alpha-D-glucosamine + diphosphate namespace: reaction xref: KEGG:R00416 "KEGG reaction" xref: METACYC:NAG1P-URIDYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13512 "Rhea reaction" relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: has_input_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: part_of UPa:UER00533 {cardinality="1", direction="LR", order="1"} ! UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1 [Term] id: UPa:UCR00425 name: GTP + 3 H(2)O = 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + diphosphate + formate namespace: reaction xref: KEGG:R00425 "KEGG reaction" xref: METACYC:GTP-CYCLOHYDRO-II-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23707 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: part_of UPa:UER00400 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4 [Term] id: UPa:UCR00428 name: GTP + H(2)O = formamidopyrimidine nucleoside triphosphate namespace: reaction xref: KEGG:R00428 "KEGG reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR00429 name: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate namespace: reaction xref: KEGG:R00429 "KEGG reaction" xref: METACYC:GTPPYPHOSKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22091 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: part_of UPa:UER00884 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 1/2 [Term] id: UPa:UCR00451 name: DL-2,6-diaminopimelate = CO(2) + L-lysine namespace: reaction xref: KEGG:R00451 "KEGG reaction" xref: METACYC:DIAMINOPIMDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15104 "Rhea reaction" relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: part_of UPa:UER00027 {cardinality="1", direction="LR", order="1"} ! L-lysine from DL-2,6-diaminopimelate: step 1/1 [Term] id: UPa:UCR00469 name: (S)-ureidoglycolate + H(2)O = CO(2) + 2 NH(3) + glyoxylate namespace: reaction xref: KEGG:R00469 "KEGG reaction" xref: METACYC:UREIDOGLYCOLATE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19812 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00656 {cardinality="1", direction="LR", order="1"} ! glyoxylate from (S)-ureidoglycolate: step 1/1 [Term] id: UPa:UCR00472 name: (S)-malate + CoA = H(2)O + acetyl-CoA + glyoxylate namespace: reaction xref: KEGG:R00472 "KEGG reaction" xref: METACYC:MALSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18184 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00720 {cardinality="1", direction="RL", order="1"} ! (S)-malate from isocitrate: step 2/2 [Term] id: UPa:UCR00475 name: O(2) + glycolate = H(2)O(2) + glyoxylate namespace: reaction xref: KEGG:R00475 "KEGG reaction" xref: METACYC:RXN-969 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25314 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00912 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 2/3 [Term] id: UPa:UCR00476 name: acceptor + glycolate = glyoxylate + reduced acceptor namespace: reaction xref: KEGG:R00476 "KEGG reaction" xref: METACYC:GLYCOLATEDEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21267 "Rhea reaction" relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00830 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 1/4 [Term] id: UPa:UCR00479 name: isocitrate = glyoxylate + succinate namespace: reaction xref: KEGG:R00479 "KEGG reaction" xref: METACYC:ISOCIT-CLEAV-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13248 "Rhea reaction" relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00048 {cardinality="1"} ! glyoxylate relationship: part_of UPa:UER00719 {cardinality="1", direction="LR", order="1"} ! (S)-malate from isocitrate: step 1/2 [Term] id: UPa:UCR00480 name: ATP + L-aspartate = 4-phospho-L-aspartate + ADP namespace: reaction xref: KEGG:R00480 "KEGG reaction" xref: METACYC:ASPARTATEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23779 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate relationship: part_of UPa:UER00015 {cardinality="1", direction="LR", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 1/4 relationship: part_of UPa:UER00461 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 1/5 relationship: part_of UPa:UER00462 {cardinality="1", direction="LR", order="1"} ! L-homoserine from L-aspartate: step 1/3 [Term] id: UPa:UCR00481 name: L-aspartate + O(2) = H(2)O(2) + iminoaspartate namespace: reaction xref: KEGG:R00481 "KEGG reaction" xref: RHEA:25879 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00326 {cardinality="1", direction="LR", order="1"} ! iminoaspartate from L-aspartate (oxidase route): step 1/1 [Term] id: UPa:UCR00483 name: ATP + L-aspartate + NH(3) = AMP + L-asparagine + diphosphate namespace: reaction xref: KEGG:R00483 "KEGG reaction" xref: METACYC:ASNSYNA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11375 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: part_of UPa:UER00194 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (ammonia route): step 1/1 [Term] id: UPa:UCR00489 name: L-aspartate = CO(2) + beta-alanine namespace: reaction xref: KEGG:R00489 "KEGG reaction" xref: METACYC:ASPDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19500 "Rhea reaction" relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: part_of UPa:UER00002 {cardinality="1", direction="LR", order="1"} ! beta-alanine from L-aspartate: step 1/1 [Term] id: UPa:UCR00497 name: ATP + L-gamma-glutamyl-L-cysteine + glycine = ADP + glutathione + phosphate namespace: reaction xref: KEGG:R00497 "KEGG reaction" xref: METACYC:GLUTATHIONE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13560 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: part_of UPa:UER00210 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 2/2 [Term] id: UPa:UCR00509 name: 5'-adenylyl sulfate + ATP = 3'-phospho-5'-adenylyl sulfate + ADP namespace: reaction xref: KEGG:R00509 "KEGG reaction" xref: METACYC:ADENYLYLSULFKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24155 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate relationship: part_of UPa:UER00205 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 2/3 [Term] id: UPa:UCR00512 name: ATP + CMP = ADP + CDP namespace: reaction xref: KEGG:R00512 "KEGG reaction" xref: METACYC:RXN-11832 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11603 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: part_of UPa:UER00641 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 2/3 [Term] id: UPa:UCR00513 name: ATP + cytidine = ADP + CMP namespace: reaction xref: KEGG:R00513 "KEGG reaction" xref: METACYC:CYTIKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24677 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: part_of UPa:UER00640 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 1/3 [Term] id: UPa:UCR00525 name: H(2)O + N-formyl-L-glutamate = L-glutamate + formate namespace: reaction xref: KEGG:R00525 "KEGG reaction" xref: METACYC:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12479 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: part_of UPa:UER00554 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 2/2 [Term] id: UPa:UCR00527 name: H(2)O + S-formylglutathione = formate + glutathione namespace: reaction xref: KEGG:R00527 "KEGG reaction" xref: METACYC:S-FORMYLGLUTATHIONE-HYDROLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14964 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: part_of UPa:UER00623 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 3/3 [Term] id: UPa:UCR00529 name: ATP + sulfate = 5'-adenylyl sulfate + diphosphate namespace: reaction xref: KEGG:R00529 "KEGG reaction" xref: METACYC:SULFATE-ADENYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18136 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00059 {cardinality="1"} ! sulfate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00224 {cardinality="1"} ! 5'-adenylyl sulfate relationship: part_of UPa:UER00204 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 1/3 [Term] id: UPa:UCR00549 name: ATP + riboflavin = ADP + FMN namespace: reaction xref: KEGG:R00549 "KEGG reaction" xref: METACYC:RIBOFLAVINKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14360 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: part_of UPa:UER00406 {cardinality="1", direction="LR", order="1"} ! FMN from riboflavin (ATP route): step 1/1 [Term] id: UPa:UCR00551 name: H(2)O + L-arginine = L-ornithine + urea namespace: reaction xref: KEGG:R00551 "KEGG reaction" xref: METACYC:ARGINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20572 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: part_of UPa:UER00270 {cardinality="1", direction="LR", order="1"} ! L-ornithine and urea from L-arginine: step 1/1 [Term] id: UPa:UCR00552 name: H(2)O + L-arginine = L-citrulline + NH(3) namespace: reaction xref: KEGG:R00552 "KEGG reaction" xref: METACYC:ARGININE-DEIMINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19600 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: part_of UPa:UER00364 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from L-arginine: step 1/2 [Term] id: UPa:UCR00565 name: L-arginine + glycine = L-ornithine + guanidinoacetate namespace: reaction xref: KEGG:R00565 "KEGG reaction" xref: METACYC:GLYCINE-AMIDINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13204 "Rhea reaction" relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate relationship: part_of UPa:UER00579 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 1/2 [Term] id: UPa:UCR00566 name: L-arginine = CO(2) + agmatine namespace: reaction xref: KEGG:R00566 "KEGG reaction" xref: METACYC:ARGDECARBOX-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17644 "Rhea reaction" relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: part_of UPa:UER00284 {cardinality="1", direction="LR", order="1"} ! agmatine from L-arginine: step 1/1 [Term] id: UPa:UCR00570 name: ATP + CDP = ADP + CTP namespace: reaction xref: KEGG:R00570 "KEGG reaction" xref: METACYC:CDPKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25240 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: part_of UPa:UER00642 {cardinality="1", direction="LR", order="1"} ! CTP from cytidine: step 3/3 [Term] id: UPa:UCR00571 name: ATP + NH(3) + UTP = ADP + CTP + phosphate namespace: reaction xref: KEGG:R00571 "KEGG reaction" xref: RHEA:16600 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00075 {cardinality="1"} ! UTP relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: part_of UPa:UER00277 {cardinality="1", direction="LR", order="1"} ! CTP from UDP: step 2/2 [Term] id: UPa:UCR00575 name: 2 ATP + H(2)O + L-glutamine + bicarbonate = 2 ADP + L-glutamate + carbamoyl phosphate + phosphate namespace: reaction xref: KEGG:R00575 "KEGG reaction" xref: METACYC:CARBPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18636 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: part_of UPa:UER00115 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 1/3 relationship: part_of UPa:UER00171 {cardinality="1", direction="LR", order="1"} ! carbamoyl phosphate from bicarbonate: step 1/1 [Term] id: UPa:UCR00578 name: ATP + H(2)O + L-aspartate + L-glutamine = AMP + L-asparagine + L-glutamate + diphosphate namespace: reaction xref: KEGG:R00578 "KEGG reaction" xref: METACYC:ASNSYNB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12231 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00152 {cardinality="1"} ! L-asparagine relationship: part_of UPa:UER00195 {cardinality="1", direction="LR", order="1"} ! L-asparagine from L-aspartate (L-Gln route): step 1/1 [Term] id: UPa:UCR00582 name: H(2)O + O-phospho-L-serine = L-serine + phosphate namespace: reaction xref: KEGG:R00582 "KEGG reaction" xref: METACYC:RXN0-5114 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21211 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: part_of UPa:UER00198 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 3/3 [Term] id: UPa:UCR00585 name: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine namespace: reaction xref: KEGG:R00585 "KEGG reaction" xref: METACYC:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22855 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: part_of UPa:UER00915 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 2/4 [Term] id: UPa:UCR00586 name: L-serine + acetyl-CoA = CoA + O-acetyl-L-serine namespace: reaction xref: KEGG:R00586 "KEGG reaction" xref: METACYC:SERINE-O-ACETTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24563 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine relationship: part_of UPa:UER00199 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 1/2 [Term] id: UPa:UCR00605 name: NAD(+) + methanol = H(+) + NADH + formaldehyde namespace: reaction xref: KEGG:R00605 "KEGG reaction" xref: METACYC:METHANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19404 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00132 {cardinality="1"} ! methanol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00893 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methanol: step 1/1 [Term] id: UPa:UCR00606 name: H(2)O + amicyanin + methylamine = 2 H(+) + NH(3) + formaldehyde + reduced amicyanin namespace: reaction xref: KEGG:R00606 "KEGG reaction" xref: METACYC:RXN-2841 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30210 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00218 {cardinality="1"} ! methylamine relationship: has_input_compound UPa:UPC19671 {cardinality="1"} ! amicyanin relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC19672 {cardinality="1"} ! reduced amicyanin relationship: part_of UPa:UER00870 {cardinality="1", direction="LR", order="1"} ! formaldehyde from methylamine: step 1/1 [Term] id: UPa:UCR00611 name: H(2)O + electron-transferring flavoprotein + sarcosine = formaldehyde + glycine + reduced electron-transferring flavoprotein namespace: reaction xref: KEGG:R00611 "KEGG reaction" xref: METACYC:SARCOSINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19796 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein relationship: part_of UPa:UER00398 {cardinality="1", direction="LR", order="1"} ! formaldehyde and glycine from sarcosine: step 1/1 [Term] id: UPa:UCR00617 name: ATP + thiamine phosphate = ADP + thiamine diphosphate namespace: reaction xref: KEGG:R00617 "KEGG reaction" xref: METACYC:THI-P-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15916 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UER00142 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine phosphate: step 1/1 [Term] id: UPa:UCR00619 name: ATP + thiamine = AMP + thiamine diphosphate namespace: reaction xref: KEGG:R00619 "KEGG reaction" xref: METACYC:THIAMIN-PYROPHOSPHOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11579 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: part_of UPa:UER00597 {cardinality="1", direction="LR", order="1"} ! thiamine diphosphate from thiamine: step 1/1 [Term] id: UPa:UCR00640 name: L-Galactono-1,4-lactone + 2 ferricytochrome c = 2 H(+) + L-ascorbate + 2 ferrocytochrome c namespace: reaction xref: KEGG:R00640 "KEGG reaction" xref: METACYC:GALACTONOLACTONE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14760 "Rhea reaction" relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC01115 {cardinality="1"} ! L-Galactono-1,4-lactone relationship: has_output_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: part_of UPa:UER00935 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 5/5 [Term] id: UPa:UCR00647 name: L-ascorbate = L-xylo-hexulonolactone namespace: reaction xref: KEGG:R00647 "KEGG reaction" xref: METACYC:RXN-8784 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15272 "Rhea reaction" relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone relationship: part_of UPa:UER00939 {cardinality="1", direction="RL", order="2"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 [Term] id: UPa:UCR00658 name: 2-phospho-D-glycerate = H(2)O + phosphoenolpyruvate namespace: reaction xref: KEGG:R00658 "KEGG reaction" xref: METACYC:2PGADEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10167 "Rhea reaction" relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: part_of UPa:UER00187 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 4/5 [Term] id: UPa:UCR00667 name: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R00667 "KEGG reaction" xref: METACYC:ORNITHINE-GLU-AMINOTRANSFORASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25163 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: part_of UPa:UER00358 {cardinality="1", direction="LR", order="1"} ! L-glutamate 5-semialdehyde from L-ornithine: step 1/1 [Term] id: UPa:UCR00669 name: H(2)O + N(2)-acetyl-L-ornithine = L-ornithine + acetate namespace: reaction xref: KEGG:R00669 "KEGG reaction" xref: METACYC:ACETYLORNDEACET-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15944 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: part_of UPa:UER00110 {cardinality="1", direction="LR", order="1"} ! L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1 [Term] id: UPa:UCR00670 name: L-ornithine = CO(2) + putrescine namespace: reaction xref: KEGG:R00670 "KEGG reaction" xref: METACYC:ORNDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22967 "Rhea reaction" relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UER00288 {cardinality="1", direction="LR", order="1"} ! putrescine from L-ornithine: step 1/1 [Term] id: UPa:UCR00671 name: L-ornithine = L-proline + NH(3) namespace: reaction xref: KEGG:R00671 "KEGG reaction" xref: METACYC:ORNITHINE-CYCLODEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24371 "Rhea reaction" relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: part_of UPa:UER00357 {cardinality="1", direction="LR", order="1"} ! L-proline from L-ornithine: step 1/1 [Term] id: UPa:UCR00673 name: H(2)O + L-tryptophan = NH(3) + indole + pyruvate namespace: reaction xref: KEGG:R00673 "KEGG reaction" xref: METACYC:TRYPTOPHAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19556 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: part_of UPa:UER00452 {cardinality="1", direction="LR", order="1"} ! indole and pyruvate from L-tryptophan: step 1/1 [Term] id: UPa:UCR00674 name: L-serine + indole = H(2)O + L-tryptophan namespace: reaction xref: KEGG:R00674 "KEGG reaction" xref: METACYC:RXN0-2382 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26437 "Rhea reaction" relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="2"} ! L-tryptophan from chorismate: step 5/5 [Term] id: UPa:UCR00678 name: L-tryptophan + O(2) = N-formyl-N-kynurenine namespace: reaction xref: KEGG:R00678 "KEGG reaction" xref: METACYC:RXN-8665 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24539 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_output_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine relationship: part_of UPa:UER00453 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 1/2 [Term] id: UPa:UCR00688 name: H(2)O + L-phenylalanine + NAD(+) = H(+) + NADH + NH(3) + phenylpyruvate namespace: reaction xref: KEGG:R00688 "KEGG reaction" xref: METACYC:PHENYLALANINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21411 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UER00346 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (PDH route): step 1/1 [Term] id: UPa:UCR00691 name: L-arogenate = CO(2) + H(2)O + L-phenylalanine namespace: reaction xref: KEGG:R00691 "KEGG reaction" xref: METACYC:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12539 "Rhea reaction" relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: part_of UPa:UER00344 {cardinality="1", direction="LR", order="1"} ! L-phenylalanine from L-arogenate: step 1/1 [Term] id: UPa:UCR00694 name: 2-oxoglutarate + L-phenylalanine = L-glutamate + phenylpyruvate namespace: reaction xref: KEGG:R00694 "KEGG reaction" xref: METACYC:PHEAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25155 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UER00347 {cardinality="1", direction="RL", order="1"} ! L-phenylalanine from phenylpyruvate (ArAT route): step 1/1 [Term] id: UPa:UCR00697 name: L-phenylalanine = NH(3) + trans-cinnamate namespace: reaction xref: KEGG:R00697 "KEGG reaction" xref: METACYC:PHENYLALANINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21387 "Rhea reaction" relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: part_of UPa:UER00725 {cardinality="1", direction="LR", order="1"} ! trans-cinnamate from L-phenylalanine: step 1/1 [Term] id: UPa:UCR00699 name: L-phenylalanine = 2-phenylethylamine + CO(2) namespace: reaction xref: KEGG:R00699 "KEGG reaction" xref: METACYC:PHENYLALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19720 "Rhea reaction" relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine relationship: part_of UPa:UER00722 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 1/3 [Term] id: UPa:UCR00703 name: (S)-lactate + NAD(+) = H(+) + NADH + pyruvate namespace: reaction xref: KEGG:R00703 "KEGG reaction" xref: METACYC:L-LACTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23447 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00186 {cardinality="1"} ! (S)-lactate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00611 {cardinality="1", direction="RL", order="1"} ! (S)-lactate from pyruvate: step 1/1 [Term] id: UPa:UCR00705 name: 3-oxopropanoate + CoA + NAD(+) = CO(2) + H(+) + NADH + acetyl-CoA namespace: reaction xref: KEGG:R00705 "KEGG reaction" xref: METACYC:RXN-2902 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22995 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00951 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR00706 name: 3-oxopropanoate + CoA + NADP(+) = CO(2) + H(+) + NADPH + acetyl-CoA namespace: reaction xref: KEGG:R00706 "KEGG reaction" xref: METACYC:1.2.1.18-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22991 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00952 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR00707 name: (S)-1-pyrroline-5-carboxylic acid + 2 H(2)O + NAD(+) = H(+) + L-glutamate + NADH namespace: reaction xref: KEGG:R00707 "KEGG reaction" xref: METACYC:PYRROLINECARBDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-11632 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:16420 "Rhea reaction" xref: RHEA:24893 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00374 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 2/2 [Term] id: UPa:UCR00709 name: NAD(+) + isocitrate = 2-oxoglutarate + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R00709 "KEGG reaction" xref: METACYC:ISOCITRATE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-7969 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:23635 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00996 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from isocitrate (NAD(+) route): step 1/1 [Term] id: UPa:UCR00710 name: H(2)O + NAD(+) + acetaldehyde = H(+) + NADH + acetate namespace: reaction xref: KEGG:R00710 "KEGG reaction" xref: METACYC:RXN66-3 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25297 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00768 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 2/2 [Term] id: UPa:UCR00713 name: H(2)O + NAD(+) + succinate semialdehyde = H(+) + NADH + succinate namespace: reaction xref: KEGG:R00713 "KEGG reaction" xref: METACYC:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13220 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER01003 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR00714 name: H(2)O + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinate namespace: reaction xref: KEGG:R00714 "KEGG reaction" xref: METACYC:SUCCSEMIALDDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13216 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER01004 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR00715 name: H(2)O + NAD(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADH namespace: reaction xref: KEGG:R00715 "KEGG reaction" xref: METACYC:1.5.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12443 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00034 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 3/3 [Term] id: UPa:UCR00716 name: H(2)O + NADP(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADPH namespace: reaction xref: KEGG:R00716 "KEGG reaction" xref: METACYC:1.5.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19376 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: part_of UPa:UER00835 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 1/6 [Term] id: UPa:UCR00731 name: L-tyrosine + O(2) = H(2)O + L-dopa namespace: reaction xref: KEGG:R00731 "KEGG reaction" xref: RHEA:34286 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00355 {cardinality="1"} ! L-dopa relationship: part_of UPa:UER00733 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 1/2 [Term] id: UPa:UCR00732 name: L-arogenate + NAD(+) = CO(2) + H(+) + L-tyrosine + NADH namespace: reaction xref: KEGG:R00732 "KEGG reaction" xref: METACYC:CYCLOHEXADIENYL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12259 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UER00959 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NAD(+) route): step 1/1 [Term] id: UPa:UCR00733 name: L-arogenate + NADP(+) = CO(2) + H(+) + L-tyrosine + NADPH namespace: reaction xref: KEGG:R00733 "KEGG reaction" xref: METACYC:RXN-5682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15420 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: part_of UPa:UER00960 {cardinality="1", direction="LR", order="1"} ! L-tyrosine from L-arogenate (NADP(+) route): step 1/1 [Term] id: UPa:UCR00734 name: 2-oxoglutarate + L-tyrosine = (4-hydroxyphenyl)pyruvate + L-glutamate namespace: reaction xref: KEGG:R00734 "KEGG reaction" xref: METACYC:TYROSINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15096 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00338 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 2/6 relationship: part_of UPa:UER00350 {cardinality="1", direction="RL", order="1"} ! L-tyrosine from (4-hydroxyphenyl)pyruvate: step 1/1 [Term] id: UPa:UCR00742 name: ATP + acetyl-CoA + bicarbonate = ADP + malonyl-CoA + phosphate namespace: reaction xref: KEGG:R00742 "KEGG reaction" xref: METACYC:ACETYL-COA-CARBOXYLTRANSFER-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11311 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: part_of UPa:UER00711 {cardinality="1", direction="LR", order="1"} ! malonyl-CoA from acetyl-CoA: step 1/1 [Term] id: UPa:UCR00750 name: acetaldehyde + pyruvate = 4-hydroxy-2-oxopentanoate namespace: reaction xref: KEGG:R00750 "KEGG reaction" xref: METACYC:MHPELY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22627 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:UER00797 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 4/4 relationship: part_of UPa:UER00907 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 7/7 [Term] id: UPa:UCR00751 name: L-threonine = acetaldehyde + glycine namespace: reaction xref: KEGG:R00751 "KEGG reaction" xref: METACYC:THREONINE-ALDOLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19628 "Rhea reaction" relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UER00429 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and glycine from L-threonine: step 1/1 [Term] id: UPa:UCR00754 name: NAD(+) + ethanol = H(+) + NADH + acetaldehyde namespace: reaction xref: KEGG:R00754 "KEGG reaction" xref: METACYC:ALCOHOL-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25293 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00469 {cardinality="1"} ! ethanol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UER00767 {cardinality="1", direction="LR", order="1"} ! acetate from ethanol: step 1/2 [Term] id: UPa:UCR00756 name: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate namespace: reaction xref: KEGG:R00756 "KEGG reaction" xref: METACYC:6PFRUCTPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16112 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate relationship: part_of UPa:UER00182 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4 [Term] id: UPa:UCR00765 name: H(2)O + alpha-D-glucosamine 6-phosphate = D-fructose 6-phosphate + NH(3) namespace: reaction xref: KEGG:R00765 "KEGG reaction" xref: METACYC:GLUCOSAMINE-6-P-DEAMIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12175 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00684 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 5/5 [Term] id: UPa:UCR00766 name: D-fructose 6-phosphate + UDP-alpha-D-glucose = UDP + sucrose 6-phosphate namespace: reaction xref: KEGG:R00766 "KEGG reaction" xref: METACYC:SUCROSE-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22175 "Rhea reaction" relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate relationship: part_of UPa:UER00545 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 1/2 [Term] id: UPa:UCR00768 name: D-fructose 6-phosphate + L-glutamine = L-glutamate + alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R00768 "KEGG reaction" xref: METACYC:L-GLN-FRUCT-6-P-AMINOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13240 "Rhea reaction" relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00528 {cardinality="1", direction="LR", order="1"} ! alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1 [Term] id: UPa:UCR00771 name: D-glucose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R00771 "KEGG reaction" xref: METACYC:PGLUCISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: METACYC:RXN-6182 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:11819 "Rhea reaction" relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00181 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4 [Term] id: UPa:UCR00772 name: D-mannose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R00772 "KEGG reaction" xref: METACYC:MANNPISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12359 "Rhea reaction" relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00423 {cardinality="1", direction="RL", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2 [Term] id: UPa:UCR00774 name: ATP + bicarbonate + urea = ADP + phosphate + urea-1-carboxylate namespace: reaction xref: KEGG:R00774 "KEGG reaction" xref: METACYC:UREA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20899 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01010 {cardinality="1"} ! urea-1-carboxylate relationship: part_of UPa:UER00371 {cardinality="1", direction="LR", order="1"} ! CO(2) and NH(3) from urea (allophanate route): step 1/2 [Term] id: UPa:UCR00783 name: H(2)O + ferricytochrome c + nitric oxide = H(+) + ferrocytochrome c + nitrite namespace: reaction xref: KEGG:R00783 "KEGG reaction" xref: METACYC:NITRITE-REDUCTASE-CYTOCHROME-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15236 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00533 {cardinality="1"} ! nitric oxide relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00088 {cardinality="1"} ! nitrite relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: part_of UPa:UER00707 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 2/4 [Term] id: UPa:UCR00798 name: H(2)O + acceptor + nitrite = nitrate + reduced acceptor namespace: reaction xref: KEGG:R00798 "KEGG reaction" xref: METACYC:NITRATREDUCT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21071 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00088 {cardinality="1"} ! nitrite relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00244 {cardinality="1"} ! nitrate relationship: part_of UPa:UER00706 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 1/4 [Term] id: UPa:UCR00805 name: H(2)O + sucrose 6-phosphate = phosphate + sucrose namespace: reaction xref: KEGG:R00805 "KEGG reaction" xref: METACYC:SUCROSE-PHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19292 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02591 {cardinality="1"} ! sucrose 6-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00089 {cardinality="1"} ! sucrose relationship: part_of UPa:UER00546 {cardinality="1", direction="LR", order="1"} ! sucrose from D-fructose 6-phosphate and UDP-alpha-D-glucose: step 2/2 [Term] id: UPa:UCR00812 name: NAD(+) + cis-1,2-dihydrobenzene-1,2-diol = H(+) + NADH + catechol namespace: reaction xref: KEGG:R00812 "KEGG reaction" xref: METACYC:1.3.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15460 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: part_of UPa:UER00392 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 2/2 [Term] id: UPa:UCR00813 name: (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+) = CO(2) + H(+) + NADH + catechol namespace: reaction xref: KEGG:R00813 "KEGG reaction" xref: METACYC:1.3.1.25-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11563 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: part_of UPa:UER00255 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 2/2 [Term] id: UPa:UCR00817 name: O(2) + catechol = cis,cis-muconate namespace: reaction xref: KEGG:R00817 "KEGG reaction" xref: METACYC:CATECHOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23855 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate relationship: part_of UPa:UER00258 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3 [Term] id: UPa:UCR00823 name: H(+) + NADH + O(2) + anthranilate = CO(2) + NAD(+) + NH(3) + catechol namespace: reaction xref: KEGG:R00823 "KEGG reaction" xref: RHEA:11079 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: part_of UPa:UER01026 {cardinality="1", direction="LR", order="1"} ! catechol from anthranilate: step 1/1 [Term] id: UPa:UCR00829 name: acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA namespace: reaction xref: KEGG:R00829 "KEGG reaction" xref: METACYC:RXN-3641 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19484 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA relationship: part_of UPa:UER00263 {cardinality="1", direction="RL", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 [Term] id: UPa:UCR00830 name: glycine + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA namespace: reaction xref: KEGG:R00830 "KEGG reaction" xref: METACYC:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12924 "Rhea reaction" relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: part_of UPa:UER00375 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from glycine: step 1/1 [Term] id: UPa:UCR00832 name: L-arginine + succinyl-CoA = CoA + N(2)-succinyl-L-arginine namespace: reaction xref: KEGG:R00832 "KEGG reaction" xref: METACYC:ARGININE-N-SUCCINYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15188 "Rhea reaction" relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine relationship: part_of UPa:UER00279 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 1/5 [Term] id: UPa:UCR00833 name: (R)-methylmalonyl-CoA = succinyl-CoA namespace: reaction xref: KEGG:R00833 "KEGG reaction" xref: METACYC:METHYLMALONYL-COA-MUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22891 "Rhea reaction" relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UER00910 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 3/3 [Term] id: UPa:UCR00835 name: D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R00835 "KEGG reaction" xref: METACYC:RXN-14819 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15844 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate relationship: part_of UPa:UER00408 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 [Term] id: UPa:UCR00847 name: ATP + glycerol = ADP + sn-glycerol 3-phosphate namespace: reaction xref: KEGG:R00847 "KEGG reaction" xref: METACYC:GLYCEROL-KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21647 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: part_of UPa:UER00672 {cardinality="1", direction="LR", order="1"} ! sn-glycerol 3-phosphate from glycerol: step 1/1 [Term] id: UPa:UCR00849 name: Quinone + sn-glycerol 3-phosphate = Hydroquinone + glycerone phosphate namespace: reaction xref: KEGG:R00849 "KEGG reaction" xref: RHEA:18980 "Rhea reaction" relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER00673 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1 relationship: part_of UPa:UER00674 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1 [Term] id: UPa:UCR00851 name: acyl-CoA + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + CoA namespace: reaction xref: KEGG:R00851 "KEGG reaction" xref: METACYC:RXN-1381 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15328 "Rhea reaction" relationship: has_input_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate relationship: part_of UPa:UER00612 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3 [Term] id: UPa:UCR00858 name: 3 H(2)O + 3 NADP(+) + hydrogen sulfide = 3 H(+) + 3 NADPH + sulfite namespace: reaction xref: KEGG:R00858 "KEGG reaction" xref: METACYC:SULFITE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13804 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: part_of UPa:UER00207 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (NADPH route): step 1/1 [Term] id: UPa:UCR00859 name: 3 H(2)O + hydrogen sulfide + 6 oxidized ferredoxin = 6 H(+) + 6 reduced ferredoxin + sulfite namespace: reaction xref: KEGG:R00859 "KEGG reaction" xref: METACYC:SULFITE-REDUCTASE-FERREDOXIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23135 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: part_of UPa:UER00208 {cardinality="1", direction="RL", order="1"} ! hydrogen sulfide from sulfite (ferredoxin route): step 1/1 [Term] id: UPa:UCR00874 name: D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol namespace: reaction xref: KEGG:R00874 "KEGG reaction" xref: METACYC:1.1.99.28-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20640 "Rhea reaction" relationship: has_input_compound UPa:UPC00031 {cardinality="1"} ! D-glucose relationship: has_input_compound UPa:UPC00095 {cardinality="1"} ! D-fructose relationship: has_output_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: part_of UPa:UER00784 {cardinality="1", direction="LR", order="1"} ! D-sorbitol from D-fructose and D-glucose: step 1/1 [Term] id: UPa:UCR00883 name: GDP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + phosphate namespace: reaction xref: KEGG:R00883 "KEGG reaction" xref: METACYC:MANNPGUANYLTRANGDP-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12908 "Rhea reaction" relationship: has_input_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: part_of UPa:UER00425 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GDP route): step 1/1 [Term] id: UPa:UCR00885 name: GTP + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + diphosphate namespace: reaction xref: KEGG:R00885 "KEGG reaction" xref: METACYC:2.7.7.13-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15232 "Rhea reaction" relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: part_of UPa:UER00930 {cardinality="1", direction="LR", order="1"} ! GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1 [Term] id: UPa:UCR00888 name: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O namespace: reaction xref: KEGG:R00888 "KEGG reaction" xref: METACYC:GDPMANDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23823 "Rhea reaction" relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:UER00190 {cardinality="1", direction="LR", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 1/2 [Term] id: UPa:UCR00893 name: L-cysteine + O(2) = 3-sulfino-L-alanine namespace: reaction xref: KEGG:R00893 "KEGG reaction" xref: METACYC:CYSTEINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20444 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine relationship: part_of UPa:UER00537 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 1/2 [Term] id: UPa:UCR00894 name: ATP + L-cysteine + L-glutamate = ADP + L-gamma-glutamyl-L-cysteine + phosphate namespace: reaction xref: KEGG:R00894 "KEGG reaction" xref: METACYC:GLUTCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13288 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00669 {cardinality="1"} ! L-gamma-glutamyl-L-cysteine relationship: part_of UPa:UER00209 {cardinality="1", direction="LR", order="1"} ! glutathione from L-cysteine and L-glutamate: step 1/2 [Term] id: UPa:UCR00897 name: O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate namespace: reaction xref: KEGG:R00897 "KEGG reaction" xref: METACYC:ACSERLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14832 "Rhea reaction" relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00979 {cardinality="1"} ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: part_of UPa:UER00200 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-serine: step 2/2 [Term] id: UPa:UCR00901 name: L-cysteine + sulfite = L-cysteate + hydrogen sulfide namespace: reaction xref: KEGG:R00901 "KEGG reaction" xref: METACYC:CYSTEINE-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20919 "Rhea reaction" relationship: has_input_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_output_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate relationship: part_of UPa:UER00540 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 1/2 [Term] id: UPa:UCR00921 name: phosphate + propanoyl-CoA = CoA + propanoyl phosphate namespace: reaction xref: KEGG:R00921 "KEGG reaction" xref: METACYC:PTAALT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28049 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate relationship: part_of UPa:UER00509 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 3/4 [Term] id: UPa:UCR00939 name: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH namespace: reaction xref: KEGG:R00939 "KEGG reaction" xref: METACYC:DIHYDROFOLATEREDUCT-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15012 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: part_of UPa:UER00158 {cardinality="1", direction="RL", order="1"} ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1 [Term] id: UPa:UCR00944 name: 10-formyl-5,6,7,8-tetrahydrofolate + H(2)O = 5,6,7,8-tetrahydrofolate + formate namespace: reaction xref: KEGG:R00944 "KEGG reaction" xref: METACYC:FORMYLTHFDEFORMYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19836 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00170 {cardinality="1", direction="LR", order="1"} ! formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1 [Term] id: UPa:UCR00945 name: 5,10-methylene-THF + H(2)O + glycine = 5,6,7,8-tetrahydrofolate + L-serine namespace: reaction xref: KEGG:R00945 "KEGG reaction" xref: METACYC:GLYOHMETRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15484 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00914 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 1/4 relationship: part_of UPa:UER01023 {cardinality="1", direction="RL", order="1"} ! glycine from L-serine: step 1/1 [Term] id: UPa:UCR00946 name: 5-methyl-THF + L-homocysteine = 5,6,7,8-tetrahydrofolate + L-methionine namespace: reaction xref: KEGG:R00946 "KEGG reaction" xref: METACYC:HOMOCYSMETB12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11175 "Rhea reaction" relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00440 {cardinality="1"} ! 5-methyl-THF relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:UER00081 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetH route): step 1/1 [Term] id: UPa:UCR00956 name: CTP + alpha-D-glucose 1-phosphate = CDP-glucose + diphosphate namespace: reaction xref: KEGG:R00956 "KEGG reaction" xref: METACYC:2.7.7.33-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18216 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00103 {cardinality="1"} ! alpha-D-glucose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose relationship: part_of UPa:UER00511 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 1/5 [Term] id: UPa:UCR00964 name: ATP + uridine = ADP + UMP namespace: reaction xref: KEGG:R00964 "KEGG reaction" xref: METACYC:URIDINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16828 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UER00637 {cardinality="1", direction="LR", order="1"} ! UMP from uridine: step 1/1 [Term] id: UPa:UCR00965 name: orotidine 5'-phosphate = CO(2) + UMP namespace: reaction xref: KEGG:R00965 "KEGG reaction" xref: METACYC:OROTPDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11599 "Rhea reaction" relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: part_of UPa:UER00120 {cardinality="1", direction="LR", order="1"} ! UMP from orotate: step 2/2 [Term] id: UPa:UCR00966 name: UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil namespace: reaction xref: KEGG:R00966 "KEGG reaction" xref: METACYC:URACIL-PRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13020 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00636 {cardinality="1", direction="RL", order="1"} ! UMP from uracil: step 1/1 [Term] id: UPa:UCR00974 name: H(2)O + cytosine = NH(3) + uracil namespace: reaction xref: KEGG:R00974 "KEGG reaction" xref: METACYC:CYTDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20608 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00380 {cardinality="1"} ! cytosine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: part_of UPa:UER00635 {cardinality="1", direction="LR", order="1"} ! uracil from cytosine: step 1/1 [Term] id: UPa:UCR00976 name: H(2)O + acceptor + uracil = barbiturate + reduced acceptor namespace: reaction xref: KEGG:R00976 "KEGG reaction" xref: METACYC:URACIL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22755 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00813 {cardinality="1"} ! barbiturate relationship: part_of UPa:UER00643 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 1/3 [Term] id: UPa:UCR00985 name: NH(3) + chorismate = H(2)O + anthranilate + pyruvate namespace: reaction xref: KEGG:R00985 "KEGG reaction" relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: part_of UPa:UER00040 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 1/5 [Term] id: UPa:UCR00987 name: H(2)O + L-kynurenine = L-alanine + anthranilate namespace: reaction xref: KEGG:R00987 "KEGG reaction" xref: METACYC:KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16816 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: part_of UPa:UER00455 {cardinality="1", direction="LR", order="1"} ! L-alanine and anthranilate from L-kynurenine: step 1/1 [Term] id: UPa:UCR00994 name: 2-oxobutanoate + CO(2) + H(+) + NADH = D-erythro-3-methylmalic acid + NAD(+) namespace: reaction xref: KEGG:R00994 "KEGG reaction" xref: RHEA:32718 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid relationship: part_of UPa:UER00069 {cardinality="1", direction="RL", order="1"} ! 2-oxobutanoate from pyruvate: step 3/3 [Term] id: UPa:UCR00996 name: L-threonine = 2-oxobutanoate + NH(3) namespace: reaction xref: KEGG:R00996 "KEGG reaction" xref: METACYC:THREDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22111 "Rhea reaction" relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: part_of UPa:UER00054 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from L-threonine: step 1/1 relationship: part_of UPa:UER00507 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 1/4 [Term] id: UPa:UCR01001 name: H(2)O + L-cystathionine = 2-oxobutanoate + L-cysteine + NH(3) namespace: reaction xref: KEGG:R01001 "KEGG reaction" xref: METACYC:RXN-15130 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14008 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_output_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: part_of UPa:UER00202 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 2/2 [Term] id: UPa:UCR01011 name: ATP + glycerone = ADP + glycerone phosphate namespace: reaction xref: KEGG:R01011 "KEGG reaction" xref: METACYC:GLYCERONE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15776 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00184 {cardinality="1"} ! glycerone relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: part_of UPa:UER00669 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 2/2 [Term] id: UPa:UCR01015 name: D-glyceraldehyde 3-phosphate = glycerone phosphate namespace: reaction xref: KEGG:R01015 "KEGG reaction" xref: METACYC:TRIOSEPISOMERIZATION-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18588 "Rhea reaction" relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: part_of UPa:UER00189 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 [Term] id: UPa:UCR01021 name: ATP + choline = ADP + phosphocholine namespace: reaction xref: KEGG:R01021 "KEGG reaction" xref: METACYC:CHOLINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12840 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UER00737 {cardinality="1", direction="LR", order="1"} ! phosphocholine from choline: step 1/1 [Term] id: UPa:UCR01022 name: O(2) + choline = H(2)O(2) + betaine aldehyde namespace: reaction xref: KEGG:R01022 "KEGG reaction" xref: METACYC:CHOLINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13508 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00384 {cardinality="1", direction="LR", order="1"} ! betaine from choline: step 1/1 [Term] id: UPa:UCR01025 name: acceptor + choline = betaine aldehyde + reduced acceptor namespace: reaction xref: KEGG:R01025 "KEGG reaction" xref: METACYC:CHD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17436 "Rhea reaction" relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00385 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (cytochrome c reductase route): step 1/1 [Term] id: UPa:UCR01028 name: H(2)O + choline sulfate = choline + sulfate namespace: reaction xref: KEGG:R01028 "KEGG reaction" xref: METACYC:CHOLINE-SULFATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20823 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00919 {cardinality="1"} ! choline sulfate relationship: has_output_compound UPa:UPC00059 {cardinality="1"} ! sulfate relationship: has_output_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: part_of UPa:UER00431 {cardinality="1", direction="LR", order="1"} ! choline from choline sulfate: step 1/1 [Term] id: UPa:UCR01034 name: NAD(+) + glycerol = H(+) + NADH + glycerone namespace: reaction xref: KEGG:R01034 "KEGG reaction" xref: METACYC:GLYCDEH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13772 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00184 {cardinality="1"} ! glycerone relationship: part_of UPa:UER00668 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from glycerol (oxidative route): step 1/2 [Term] id: UPa:UCR01047 name: glycerol = 3-hydroxypropanal + H(2)O namespace: reaction xref: KEGG:R01047 "KEGG reaction" xref: METACYC:GLYCEROL-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19768 "Rhea reaction" relationship: has_input_compound UPa:UPC00116 {cardinality="1"} ! glycerol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal relationship: part_of UPa:UER00670 {cardinality="1", direction="LR", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 1/2 [Term] id: UPa:UCR01049 name: ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP namespace: reaction xref: KEGG:R01049 "KEGG reaction" xref: METACYC:PRPPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15612 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00172 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1 [Term] id: UPa:UCR01051 name: ATP + D-ribose = ADP + D-ribose 5-phosphate namespace: reaction xref: KEGG:R01051 "KEGG reaction" xref: METACYC:RIBOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13700 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: part_of UPa:UER00889 {cardinality="1", direction="LR", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2 [Term] id: UPa:UCR01056 name: D-ribose 5-phosphate = D-ribulose 5-phosphate namespace: reaction xref: KEGG:R01056 "KEGG reaction" xref: METACYC:RIB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14660 "Rhea reaction" relationship: has_input_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UER00412 {cardinality="1", direction="RL", order="1"} ! D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 [Term] id: UPa:UCR01057 name: alpha-D-ribose 1-phosphate = D-ribose 5-phosphate namespace: reaction xref: KEGG:R01057 "KEGG reaction" xref: METACYC:PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18796 "Rhea reaction" relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: part_of UPa:UER00173 {cardinality="1", direction="RL", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3 [Term] id: UPa:UCR01061 name: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = 3-phospho-D-glyceroyl phosphate + H(+) + NADH namespace: reaction xref: KEGG:R01061 "KEGG reaction" xref: METACYC:GAPOXNPHOSPHN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10303 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:UER00184 {cardinality="1", direction="LR", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 1/5 [Term] id: UPa:UCR01064 name: 6-phospho-2-dehydro-3-deoxy-D-galactonic acid = D-glyceraldehyde 3-phosphate + pyruvate namespace: reaction xref: KEGG:R01064 "KEGG reaction" xref: METACYC:DEHYDDEOXPHOSGALACT-ALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24467 "Rhea reaction" relationship: has_input_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00520 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 3/3 [Term] id: UPa:UCR01066 name: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde namespace: reaction xref: KEGG:R01066 "KEGG reaction" xref: METACYC:DEOXYRIBOSE-P-ALD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12824 "Rhea reaction" relationship: has_input_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00468 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2 [Term] id: UPa:UCR01068 name: D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate namespace: reaction xref: KEGG:R01068 "KEGG reaction" xref: METACYC:F16ALDOLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14732 "Rhea reaction" relationship: has_input_compound UPa:UPC00354 {cardinality="1"} ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00183 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4 [Term] id: UPa:UCR01069 name: D-tagatose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate namespace: reaction xref: KEGG:R01069 "KEGG reaction" xref: METACYC:TAGAALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22951 "Rhea reaction" relationship: has_input_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00716 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2 [Term] id: UPa:UCR01071 name: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP namespace: reaction xref: KEGG:R01071 "KEGG reaction" xref: METACYC:ATPPHOSPHORIBOSYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18476 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00006 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9 [Term] id: UPa:UCR01072 name: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O + L-glutamine namespace: reaction xref: KEGG:R01072 "KEGG reaction" xref: METACYC:PRPPAMIDOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14908 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00124 {cardinality="1", direction="RL", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2 [Term] id: UPa:UCR01073 name: N-(5-phospho-beta-D-ribosyl)anthranilic acid + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate namespace: reaction xref: KEGG:R01073 "KEGG reaction" xref: METACYC:PRTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11771 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC00108 {cardinality="1"} ! anthranilate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00041 {cardinality="1", direction="RL", order="1"} ! L-tryptophan from chorismate: step 2/5 [Term] id: UPa:UCR01078 name: 2 H(+) + 2 S-adenosyl-L-methionine + dethiobiotin + 2 e- + sulfur donor = 2 5'-deoxyadenosine + 2 L-methionine + biotin namespace: reaction xref: KEGG:R01078 "KEGG reaction" xref: METACYC:2.8.1.6-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22063 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin relationship: has_input_compound UPa:UPC05359 {cardinality="1"} ! e- relationship: has_input_compound UPa:UPC17023 {cardinality="1"} ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC00120 {cardinality="1"} ! biotin relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: part_of UPa:UER00162 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 2/2 [Term] id: UPa:UCR01080 name: H(2)O + uridine = D-ribose + uracil namespace: reaction xref: KEGG:R01080 "KEGG reaction" xref: METACYC:URIDINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15580 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: part_of UPa:UER00634 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (hydrolase route): step 1/1 [Term] id: UPa:UCR01082 name: (S)-malate = H(2)O + fumarate namespace: reaction xref: KEGG:R01082 "KEGG reaction" xref: METACYC:FUMHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12463 "Rhea reaction" relationship: has_input_compound UPa:UPC00149 {cardinality="1"} ! (S)-malate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER01007 {cardinality="1", direction="RL", order="1"} ! (S)-malate from fumarate: step 1/1 [Term] id: UPa:UCR01083 name: N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate namespace: reaction xref: KEGG:R01083 "KEGG reaction" xref: METACYC:AMPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16856 "Rhea reaction" relationship: has_input_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER00336 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 2/2 [Term] id: UPa:UCR01086 name: (N(omega)-L-arginino)succinate = L-arginine + fumarate namespace: reaction xref: KEGG:R01086 "KEGG reaction" xref: METACYC:ARGSUCCINLYA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24023 "Rhea reaction" relationship: has_input_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: part_of UPa:UER00114 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 3/3 relationship: part_of UPa:UER00273 {cardinality="1", direction="LR", order="1"} ! L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1 [Term] id: UPa:UCR01088 name: H(2)O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH(3) namespace: reaction xref: KEGG:R01088 "KEGG reaction" xref: METACYC:LEUCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12223 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UER00858 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1 [Term] id: UPa:UCR01090 name: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R01090 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERLEU-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18324 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00123 {cardinality="1"} ! L-leucine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:UER00073 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 4/4 relationship: part_of UPa:UER00857 {cardinality="1", direction="LR", order="1"} ! 4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1 [Term] id: UPa:UCR01121 name: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + isopentenyl diphosphate + phosphate namespace: reaction xref: KEGG:R01121 "KEGG reaction" xref: METACYC:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23735 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: part_of UPa:UER00100 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 3/3 [Term] id: UPa:UCR01123 name: isopentenyl diphosphate = dimethylallyl diphosphate namespace: reaction xref: KEGG:R01123 "KEGG reaction" xref: METACYC:IPPISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23287 "Rhea reaction" relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: part_of UPa:UER00104 {cardinality="1", direction="LR", order="1"} ! dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR01127 name: H(2)O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R01127 "KEGG reaction" xref: METACYC:IMPCYCLOHYDROLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18448 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00135 {cardinality="1", direction="RL", order="1"} ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1 [Term] id: UPa:UCR01130 name: H(2)O + IMP + NAD(+) = H(+) + NADH + XMP namespace: reaction xref: KEGG:R01130 "KEGG reaction" xref: METACYC:IMP-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11711 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: part_of UPa:UER00295 {cardinality="1", direction="LR", order="1"} ! XMP from IMP: step 1/1 [Term] id: UPa:UCR01131 name: ATP + inosine = ADP + IMP namespace: reaction xref: KEGG:R01131 "KEGG reaction" xref: METACYC:INOSINEKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21143 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00294 {cardinality="1"} ! inosine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: part_of UPa:UER00647 {cardinality="1", direction="LR", order="1"} ! IMP from inosine: step 1/1 [Term] id: UPa:UCR01132 name: IMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine namespace: reaction xref: KEGG:R01132 "KEGG reaction" xref: METACYC:HYPOXANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17976 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: part_of UPa:UER00648 {cardinality="1", direction="RL", order="1"} ! IMP from hypoxanthine: step 1/1 [Term] id: UPa:UCR01135 name: GTP + IMP + L-aspartate = GDP + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate namespace: reaction xref: KEGG:R01135 "KEGG reaction" xref: METACYC:ADENYLOSUCCINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15756 "Rhea reaction" relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00130 {cardinality="1"} ! IMP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC03794 {cardinality="1"} ! N(6)-(1,2-dicarboxyethyl)-AMP relationship: part_of UPa:UER00335 {cardinality="1", direction="LR", order="1"} ! AMP from IMP: step 1/2 [Term] id: UPa:UCR01151 name: H(2)O + O(2) + putrescine = 4-aminobutanal + H(2)O(2) + NH(3) namespace: reaction xref: KEGG:R01151 "KEGG reaction" xref: METACYC:PUTRESCINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18276 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: part_of UPa:UER00289 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (amine oxidase route): step 1/1 [Term] id: UPa:UCR01152 name: H(2)O + N-carbamoylputrescine = CO(2) + NH(3) + putrescine namespace: reaction xref: KEGG:R01152 "KEGG reaction" xref: METACYC:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22287 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UER00286 {cardinality="1", direction="LR", order="1"} ! putrescine from N-carbamoylputrescine (amidase route): step 1/1 [Term] id: UPa:UCR01154 name: acetyl-CoA + putrescine = CoA + N-acetylputrescine namespace: reaction xref: KEGG:R01154 "KEGG reaction" xref: METACYC:RXN-0 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25184 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02714 {cardinality="1"} ! N-acetylputrescine relationship: part_of UPa:UER00363 {cardinality="1", direction="LR", order="1"} ! N-acetylputrescine from putrescine: step 1/1 [Term] id: UPa:UCR01155 name: 2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate namespace: reaction xref: KEGG:R01155 "KEGG reaction" xref: METACYC:PUTTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23819 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: part_of UPa:UER00290 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanal from putrescine (transaminase route): step 1/1 [Term] id: UPa:UCR01157 name: H(2)O + agmatine = putrescine + urea namespace: reaction xref: KEGG:R01157 "KEGG reaction" xref: METACYC:AGMATIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13932 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: part_of UPa:UER00287 {cardinality="1", direction="LR", order="1"} ! putrescine from agmatine: step 1/1 [Term] id: UPa:UCR01158 name: H(2)O + L-histidinol + 2 NAD(+) = 2 H(+) + L-histidine + 2 NADH namespace: reaction xref: KEGG:R01158 "KEGG reaction" xref: METACYC:RXN-8001 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20644 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: part_of UPa:UER00014 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 [Term] id: UPa:UCR01167 name: L-histidine = CO(2) + histamine namespace: reaction xref: KEGG:R01167 "KEGG reaction" xref: METACYC:HISTIDINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20843 "Rhea reaction" relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00388 {cardinality="1"} ! histamine relationship: part_of UPa:UER00786 {cardinality="1", direction="LR", order="1"} ! histamine from L-histidine: step 1/1 [Term] id: UPa:UCR01168 name: L-histidine = NH(3) + trans-urocanate namespace: reaction xref: KEGG:R01168 "KEGG reaction" xref: METACYC:HISTIDINE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21235 "Rhea reaction" relationship: has_input_compound UPa:UPC00135 {cardinality="1"} ! L-histidine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate relationship: part_of UPa:UER00549 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 1/3 [Term] id: UPa:UCR01183 name: NAD(+) + myo-inositol = H(+) + NADH + scyllo-inosose namespace: reaction xref: KEGG:R01183 "KEGG reaction" xref: METACYC:MYO-INOSITOL-2-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16952 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose relationship: part_of UPa:UER00143 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 1/7 [Term] id: UPa:UCR01184 name: O(2) + myo-inositol = D-glucuronate + H(2)O namespace: reaction xref: KEGG:R01184 "KEGG reaction" xref: METACYC:MYO-INOSITOL-OXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23699 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UER00527 {cardinality="1", direction="LR", order="1"} ! D-glucuronate from myo-inositol: step 1/1 [Term] id: UPa:UCR01187 name: 1D-myo-inositol 3-phosphate + H(2)O = myo-inositol + phosphate namespace: reaction xref: KEGG:R01187 "KEGG reaction" xref: METACYC:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30742 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: part_of UPa:UER00788 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 2/2 [Term] id: UPa:UCR01197 name: CO(2) + 2 H(+) + 2 reduced ferredoxin + succinyl-CoA = 2-oxoglutarate + CoA + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R01197 "KEGG reaction" xref: METACYC:2-OXOGLUTARATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17300 "Rhea reaction" relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: part_of UPa:UER00998 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from 2-oxoglutarate (synthase route): step 1/1 [Term] id: UPa:UCR01213 name: (2S)-2-isopropylmalate + CoA = 3-methyl-2-oxobutanoate + H(2)O + acetyl-CoA namespace: reaction xref: KEGG:R01213 "KEGG reaction" xref: METACYC:2-ISOPROPYLMALATESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21527 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00070 {cardinality="1", direction="RL", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 1/4 [Term] id: UPa:UCR01214 name: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate namespace: reaction xref: KEGG:R01214 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERVAL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24816 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00062 {cardinality="1", direction="RL", order="1"} ! L-valine from pyruvate: step 4/4 [Term] id: UPa:UCR01226 name: 3-methyl-2-oxobutanoate + 5,10-methylene-THF + H(2)O = 2-dehydropantoate + 5,6,7,8-tetrahydrofolate namespace: reaction xref: KEGG:R01226 "KEGG reaction" xref: METACYC:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11827 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00143 {cardinality="1"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate relationship: part_of UPa:UER00003 {cardinality="1", direction="LR", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2 [Term] id: UPa:UCR01229 name: GMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + guanine namespace: reaction xref: KEGG:R01229 "KEGG reaction" xref: METACYC:GUANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25427 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: part_of UPa:UER00887 {cardinality="1", direction="RL", order="1"} ! GMP from guanine: step 1/1 [Term] id: UPa:UCR01230 name: ATP + NH(3) + XMP = AMP + GMP + diphosphate namespace: reaction xref: KEGG:R01230 "KEGG reaction" xref: METACYC:GMP-SYN-NH3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18304 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00297 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (ammonia route): step 1/1 [Term] id: UPa:UCR01231 name: ATP + H(2)O + L-glutamine + XMP = AMP + GMP + L-glutamate + diphosphate namespace: reaction xref: KEGG:R01231 "KEGG reaction" xref: METACYC:GMP-SYN-GLUT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11683 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00296 {cardinality="1", direction="LR", order="1"} ! GMP from XMP (L-Gln route): step 1/1 [Term] id: UPa:UCR01234 name: 3',5'-cyclic GMP + H(2)O = GMP namespace: reaction xref: KEGG:R01234 "KEGG reaction" xref: METACYC:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16960 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00942 {cardinality="1"} ! 3',5'-cyclic GMP relationship: has_output_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: part_of UPa:UER00748 {cardinality="1", direction="LR", order="1"} ! GMP from 3',5'-cyclic GMP: step 1/1 [Term] id: UPa:UCR01248 name: L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylic acid + H(+) + NADH namespace: reaction xref: KEGG:R01248 "KEGG reaction" xref: RHEA:14108 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: part_of UPa:UER00361 {cardinality="1", direction="RL", order="2"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1 [Term] id: UPa:UCR01253 name: L-proline + Quinone = (S)-1-pyrroline-5-carboxylic acid + Hydroquinone namespace: reaction xref: KEGG:R01253 "KEGG reaction" xref: METACYC:RXN-14903 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23787 "Rhea reaction" relationship: has_input_compound UPa:UPC00148 {cardinality="1"} ! L-proline relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER00373 {cardinality="1", direction="LR", order="1"} ! L-glutamate from L-proline: step 1/2 [Term] id: UPa:UCR01268 name: H(2)O + nicotinamide = NH(3) + nicotinate namespace: reaction xref: KEGG:R01268 "KEGG reaction" xref: METACYC:NICOTINAMID-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14548 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: part_of UPa:UER00790 {cardinality="1", direction="LR", order="1"} ! nicotinate from nicotinamide: step 1/1 [Term] id: UPa:UCR01271 name: diphosphate + nicotinamide D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide namespace: reaction xref: KEGG:R01271 "KEGG reaction" xref: METACYC:2.4.2.12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16152 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00455 {cardinality="1"} ! nicotinamide D-ribonucleotide relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00153 {cardinality="1"} ! nicotinamide relationship: part_of UPa:UER00890 {cardinality="1", direction="RL", order="1"} ! nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1 [Term] id: UPa:UCR01286 name: H(2)O + L-cystathionine = L-homocysteine + NH(3) + pyruvate namespace: reaction xref: KEGG:R01286 "KEGG reaction" xref: METACYC:CYSTATHIONINE-BETA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13968 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00078 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from L-cystathionine: step 1/1 [Term] id: UPa:UCR01287 name: O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate namespace: reaction xref: KEGG:R01287 "KEGG reaction" xref: METACYC:ACETYLHOMOSER-CYS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27825 "Rhea reaction" relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00079 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-acetyl-L-homoserine: step 1/1 [Term] id: UPa:UCR01288 name: O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate namespace: reaction xref: KEGG:R01288 "KEGG reaction" xref: METACYC:RXN-9384 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27829 "Rhea reaction" relationship: has_input_compound UPa:UPC00283 {cardinality="1"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: part_of UPa:UER00449 {cardinality="1", direction="LR", order="1"} ! L-homocysteine from O-succinyl-L-homoserine: step 1/1 [Term] id: UPa:UCR01290 name: L-homocysteine + L-serine = H(2)O + L-cystathionine namespace: reaction xref: KEGG:R01290 "KEGG reaction" xref: METACYC:CYSTATHIONINE-BETA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10115 "Rhea reaction" relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: part_of UPa:UER00201 {cardinality="1", direction="LR", order="1"} ! L-cysteine from L-homocysteine and L-serine: step 1/2 [Term] id: UPa:UCR01295 name: H(+) + NADPH + O(2) + benzoate = 4-hydroxybenzoate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01295 "KEGG reaction" xref: METACYC:BENZOATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18036 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: part_of UPa:UER00256 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 1/2 [Term] id: UPa:UCR01298 name: 4-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01298 "KEGG reaction" xref: METACYC:1.14.13.33-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19480 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00257 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from benzoate: step 2/2 [Term] id: UPa:UCR01301 name: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA namespace: reaction xref: KEGG:R01301 "KEGG reaction" xref: METACYC:3.1.2.23-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11951 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00156 {cardinality="1"} ! 4-hydroxybenzoate relationship: part_of UPa:UER01022 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 3/3 [Term] id: UPa:UCR01321 name: 1,2-diacyl-sn-glycerol + CDP-choline = CMP + phosphatidylcholine namespace: reaction xref: KEGG:R01321 "KEGG reaction" xref: METACYC:RXN-5781 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10311 "Rhea reaction" xref: RHEA:32942 "Rhea reaction" relationship: has_input_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: part_of UPa:UER00740 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 2/2 [Term] id: UPa:UCR01325 name: citrate = H(2)O + cis-aconitate namespace: reaction xref: KEGG:R01325 "KEGG reaction" xref: METACYC:ACONITATEDEHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10231 "Rhea reaction" relationship: has_input_compound UPa:UPC00158 {cardinality="1"} ! citrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate relationship: part_of UPa:UER00718 {cardinality="1", direction="LR", order="1"} ! isocitrate from oxaloacetate: step 2/2 [Term] id: UPa:UCR01334 name: 2-phosphoglycolate + H(2)O = glycolate + phosphate namespace: reaction xref: KEGG:R01334 "KEGG reaction" xref: METACYC:GPH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14372 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00988 {cardinality="1"} ! 2-phosphoglycolate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: part_of UPa:UER00834 {cardinality="1", direction="LR", order="1"} ! glycolate from 2-phosphoglycolate: step 1/1 relationship: part_of UPa:UER00911 {cardinality="1", direction="LR", order="1"} ! glycine from 2-phosphoglycolate: step 1/3 [Term] id: UPa:UCR01353 name: ATP + propanoate = ADP + propanoyl phosphate namespace: reaction xref: KEGG:R01353 "KEGG reaction" xref: METACYC:PROPKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23151 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC02876 {cardinality="1"} ! propanoyl phosphate relationship: part_of UPa:UER00510 {cardinality="1", direction="RL", order="1"} ! propanoate from L-threonine: step 4/4 [Term] id: UPa:UCR01355 name: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate namespace: reaction xref: KEGG:R01355 "KEGG reaction" xref: METACYC:23-DIMETHYLMALATE-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10475 "Rhea reaction" relationship: has_input_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00163 {cardinality="1"} ! propanoate relationship: part_of UPa:UER01019 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 8/8 [Term] id: UPa:UCR01360 name: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA namespace: reaction xref: KEGG:R01360 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24407 "Rhea reaction" relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: part_of UPa:UER00863 {cardinality="1", direction="LR", order="1"} ! acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1 [Term] id: UPa:UCR01364 name: acetoacetate + fumarate = 4-fumarylacetoacetate + H(2)O namespace: reaction xref: KEGG:R01364 "KEGG reaction" xref: METACYC:FUMARYLACETOACETASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10247 "Rhea reaction" relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_input_compound UPa:UPC00164 {cardinality="1"} ! acetoacetate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate relationship: part_of UPa:UER00341 {cardinality="1", direction="RL", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 6/6 [Term] id: UPa:UCR01373 name: prephenate = CO(2) + H(2)O + phenylpyruvate namespace: reaction xref: KEGG:R01373 "KEGG reaction" xref: METACYC:PREPHENATEDEHYDRAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21651 "Rhea reaction" relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00166 {cardinality="1"} ! phenylpyruvate relationship: part_of UPa:UER00345 {cardinality="1", direction="LR", order="1"} ! phenylpyruvate from prephenate: step 1/1 [Term] id: UPa:UCR01384 name: UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose namespace: reaction xref: KEGG:R01384 "KEGG reaction" xref: METACYC:UDP-GLUCURONATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23919 "Rhea reaction" relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: part_of UPa:UER00771 {cardinality="1", direction="LR", order="1"} ! UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1 [Term] id: UPa:UCR01388 name: D-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH namespace: reaction xref: KEGG:R01388 "KEGG reaction" xref: METACYC:GLYCERATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17908 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: part_of UPa:UER00916 {cardinality="1", direction="RL", order="1"} ! 3-phospho-D-glycerate from glycine: step 3/4 relationship: part_of UPa:UER00983 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01392 name: D-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH namespace: reaction xref: KEGG:R01392 "KEGG reaction" xref: METACYC:RXN0-300 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:18660 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00168 {cardinality="1"} ! 3-hydroxypyruvate relationship: part_of UPa:UER00984 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01397 name: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + phosphate namespace: reaction xref: KEGG:R01397 "KEGG reaction" xref: METACYC:ASPCARBTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20016 "Rhea reaction" relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate relationship: part_of UPa:UER00116 {cardinality="1", direction="LR", order="1"} ! (S)-dihydroorotate from bicarbonate: step 2/3 [Term] id: UPa:UCR01398 name: L-ornithine + carbamoyl phosphate = L-citrulline + phosphate namespace: reaction xref: KEGG:R01398 "KEGG reaction" xref: METACYC:ORNCARBAMTRANSFER-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19516 "Rhea reaction" relationship: has_input_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: part_of UPa:UER00112 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 1/3 relationship: part_of UPa:UER00271 {cardinality="1", direction="LR", order="1"} ! L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1 relationship: part_of UPa:UER00365 {cardinality="1", direction="RL", order="1"} ! carbamoyl phosphate from L-arginine: step 2/2 [Term] id: UPa:UCR01399 name: carbamoyl phosphate + putrescine = N-carbamoylputrescine + phosphate namespace: reaction xref: KEGG:R01399 "KEGG reaction" xref: METACYC:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21939 "Rhea reaction" relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC00169 {cardinality="1"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: part_of UPa:UER00941 {cardinality="1", direction="RL", order="1"} ! putrescine from N-carbamoylputrescine (transferase route): step 1/1 [Term] id: UPa:UCR01401 name: H(2)O + S-methyl-5'-thioadenosine = 5-methylthio-alpha-D-ribose + adenine namespace: reaction xref: KEGG:R01401 "KEGG reaction" xref: METACYC:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13620 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_output_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose relationship: part_of UPa:UER00871 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2 [Term] id: UPa:UCR01402 name: S-methyl-5'-thioadenosine + phosphate = S-methyl-5-thio-alpha-D-ribose 1-phosphate + adenine namespace: reaction xref: KEGG:R01402 "KEGG reaction" xref: METACYC:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11855 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00147 {cardinality="1"} ! adenine relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00873 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1 [Term] id: UPa:UCR01416 name: H(2)O + agmatine = N-carbamoylputrescine + NH(3) namespace: reaction xref: KEGG:R01416 "KEGG reaction" xref: METACYC:AGMATINE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18040 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00179 {cardinality="1"} ! agmatine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00436 {cardinality="1"} ! N-carbamoylputrescine relationship: part_of UPa:UER00285 {cardinality="1", direction="LR", order="1"} ! N-carbamoylputrescine from agmatine: step 1/1 [Term] id: UPa:UCR01419 name: H(2)O + NAD(+) + benzaldehyde = H(+) + NADH + benzoate namespace: reaction xref: KEGG:R01419 "KEGG reaction" xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11843 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: part_of UPa:UER00988 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01420 name: H(2)O + NADP(+) + benzaldehyde = H(+) + NADPH + benzoate namespace: reaction xref: KEGG:R01420 "KEGG reaction" xref: METACYC:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21663 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: part_of UPa:UER00987 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01465 name: L-threonine + NAD(+) = H(+) + L-2-amino-3-oxobutanoic acid + NADH namespace: reaction xref: KEGG:R01465 "KEGG reaction" xref: METACYC:THREODEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13164 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03508 {cardinality="1"} ! L-2-amino-3-oxobutanoic acid relationship: part_of UPa:UER00505 {cardinality="1", direction="LR", order="1"} ! glycine from L-threonine: step 1/2 [Term] id: UPa:UCR01466 name: H(2)O + O-phospho-L-homoserine = L-threonine + phosphate namespace: reaction xref: KEGG:R01466 "KEGG reaction" xref: METACYC:THRESYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10843 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00188 {cardinality="1"} ! L-threonine relationship: part_of UPa:UER00065 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 5/5 [Term] id: UPa:UCR01468 name: ATP + ethanolamine = ADP + phosphoethanolamine namespace: reaction xref: KEGG:R01468 "KEGG reaction" xref: METACYC:ETHANOLAMINE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13072 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00189 {cardinality="1"} ! ethanolamine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: part_of UPa:UER00741 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 1/3 [Term] id: UPa:UCR01473 name: UDP-L-arabinose = UDP-alpha-D-xylose namespace: reaction xref: KEGG:R01473 "KEGG reaction" xref: METACYC:UDP-ARABINOSE-4-EPIMERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11323 "Rhea reaction" relationship: has_input_compound UPa:UPC00935 {cardinality="1"} ! UDP-L-arabinose relationship: has_output_compound UPa:UPC00190 {cardinality="1"} ! UDP-alpha-D-xylose relationship: part_of UPa:UER00772 {cardinality="1", direction="RL", order="1"} ! UDP-L-arabinose from UDP-alpha-D-xylose: step 1/1 [Term] id: UPa:UCR01481 name: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH namespace: reaction xref: KEGG:R01481 "KEGG reaction" xref: METACYC:GLUCURONATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14912 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UER00937 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 2/4 [Term] id: UPa:UCR01512 name: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP namespace: reaction xref: KEGG:R01512 "KEGG reaction" xref: METACYC:PHOSGLYPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14804 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00236 {cardinality="1"} ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:UER00185 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 2/5 [Term] id: UPa:UCR01513 name: 3-phospho-D-glycerate + NAD(+) = 3-phosphohydroxypyruvate + H(+) + NADH namespace: reaction xref: KEGG:R01513 "KEGG reaction" xref: METACYC:PGLYCDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12644 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:UER00196 {cardinality="1", direction="LR", order="1"} ! L-serine from 3-phospho-D-glycerate: step 1/3 [Term] id: UPa:UCR01514 name: ATP + D-glycerate = 3-phospho-D-glycerate + ADP namespace: reaction xref: KEGG:R01514 "KEGG reaction" xref: METACYC:GLY3KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23519 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: part_of UPa:UER00833 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycolate: step 4/4 relationship: part_of UPa:UER00917 {cardinality="1", direction="LR", order="1"} ! 3-phospho-D-glycerate from glycine: step 4/4 [Term] id: UPa:UCR01518 name: 2-phospho-D-glycerate = 3-phospho-D-glycerate namespace: reaction xref: KEGG:R01518 "KEGG reaction" xref: METACYC:3PGAREARR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15904 "Rhea reaction" relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: part_of UPa:UER00186 {cardinality="1", direction="RL", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate: step 3/5 [Term] id: UPa:UCR01519 name: D-glucono-1,5-lactone + H(2)O = D-gluconate namespace: reaction xref: KEGG:R01519 "KEGG reaction" xref: METACYC:GLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10443 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00198 {cardinality="1"} ! D-glucono-1,5-lactone relationship: has_output_compound UPa:UPC00257 {cardinality="1"} ! D-gluconate relationship: part_of UPa:UER00785 {cardinality="1", direction="LR", order="1"} ! D-gluconate from D-glucono-1,5-lactone: step 1/1 [Term] id: UPa:UCR01528 name: 6-phospho-D-gluconate + NADP(+) = CO(2) + D-ribulose 5-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R01528 "KEGG reaction" xref: METACYC:RXN-9952 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10119 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UER00410 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 [Term] id: UPa:UCR01529 name: D-ribulose 5-phosphate = D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01529 "KEGG reaction" xref: METACYC:RIBULP3EPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13680 "Rhea reaction" relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00411 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1 [Term] id: UPa:UCR01530 name: D-arabinose 5-phosphate = D-ribulose 5-phosphate namespace: reaction xref: KEGG:R01530 "KEGG reaction" xref: METACYC:DARAB5PISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23107 "Rhea reaction" relationship: has_input_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate relationship: has_output_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: part_of UPa:UER00473 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 1/3 [Term] id: UPa:UCR01541 name: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconic acid + ADP namespace: reaction xref: KEGG:R01541 "KEGG reaction" xref: METACYC:DEOXYGLUCONOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14800 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: part_of UPa:UER00828 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 1/2 [Term] id: UPa:UCR01542 name: 2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-hexo-2,5-diulosonate + H(+) + NADH namespace: reaction xref: KEGG:R01542 "KEGG reaction" xref: METACYC:1.1.1.127-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24235 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00204 {cardinality="1"} ! 2-dehydro-3-deoxy-D-gluconate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: part_of UPa:UER00827 {cardinality="1", direction="RL", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 5/5 [Term] id: UPa:UCR01563 name: H(2)O + N-carbamoylsarcosine = CO(2) + NH(3) + sarcosine namespace: reaction xref: KEGG:R01563 "KEGG reaction" xref: METACYC:N-CARBAMOYLSARCOSINE-AMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20060 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: part_of UPa:UER00397 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 3/3 [Term] id: UPa:UCR01565 name: H(2)O + N,N-dimethylglycine + electron-transferring flavoprotein = formaldehyde + reduced electron-transferring flavoprotein + sarcosine namespace: reaction xref: KEGG:R01565 "KEGG reaction" xref: METACYC:DIMETHYLGLYCINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22499 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: has_input_compound UPa:UPC04253 {cardinality="1"} ! electron-transferring flavoprotein relationship: has_output_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_output_compound UPa:UPC04570 {cardinality="1"} ! reduced electron-transferring flavoprotein relationship: part_of UPa:UER00433 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 2/2 [Term] id: UPa:UCR01567 name: ATP + thymidine = ADP + dTMP namespace: reaction xref: KEGG:R01567 "KEGG reaction" xref: METACYC:THYKI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19132 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00364 {cardinality="1"} ! dTMP relationship: part_of UPa:UER00639 {cardinality="1", direction="LR", order="1"} ! dTMP from thymine: step 2/2 [Term] id: UPa:UCR01570 name: phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine namespace: reaction xref: KEGG:R01570 "KEGG reaction" xref: METACYC:THYM-PHOSPH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16040 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00214 {cardinality="1"} ! thymidine relationship: has_output_compound UPa:UPC00178 {cardinality="1"} ! thymine relationship: has_output_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00638 {cardinality="1", direction="RL", order="1"} ! dTMP from thymine: step 1/2 [Term] id: UPa:UCR01574 name: D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH namespace: reaction xref: KEGG:R01574 "KEGG reaction" xref: METACYC:D-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20460 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00977 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01575 name: D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH namespace: reaction xref: KEGG:R01575 "KEGG reaction" xref: METACYC:RXN-8776 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21895 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00216 {cardinality="1"} ! D-arabinose relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: part_of UPa:UER00978 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01614 name: 4-coumaroyl-CoA + 3 malonyl-CoA = 3,4',5-trihydroxystilbene + 4 CO(2) + 4 CoA namespace: reaction xref: KEGG:R01614 "KEGG reaction" xref: METACYC:RXN-87 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11939 "Rhea reaction" relationship: has_input_compound UPa:UPC00083 {cardinality="1"} ! malonyl-CoA relationship: has_input_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03582 {cardinality="1"} ! 3,4',5-trihydroxystilbene relationship: part_of UPa:UER00548 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 2/2 [Term] id: UPa:UCR01616 name: ATP + CoA + trans-4-coumarate = 4-coumaroyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R01616 "KEGG reaction" xref: METACYC:4-COUMARATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19644 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00223 {cardinality="1"} ! 4-coumaroyl-CoA relationship: part_of UPa:UER00547 {cardinality="1", direction="LR", order="1"} ! 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2 [Term] id: UPa:UCR01620 name: L-lysine + acetyl phosphate = N(6)-acetyl-L-lysine + phosphate namespace: reaction xref: KEGG:R01620 "KEGG reaction" xref: METACYC:LYSINE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14420 "Rhea reaction" relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine relationship: part_of UPa:UER00841 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 1/6 [Term] id: UPa:UCR01627 name: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H(2)O namespace: reaction xref: KEGG:R01627 "KEGG reaction" xref: METACYC:DHSHIKIMATE-DEHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24851 "Rhea reaction" relationship: has_input_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00179 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2 [Term] id: UPa:UCR01629 name: 3,4-dihydroxybenzoate + H(+) + NADH + O(2) = CO(2) + H(2)O + NAD(+) + benzene-1,2,4-triol namespace: reaction xref: KEGG:R01629 "KEGG reaction" xref: RHEA:30038 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: part_of UPa:UER00955 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01630 name: 3,4-dihydroxybenzoate + H(+) + NADPH + O(2) = CO(2) + H(2)O + NADP(+) + benzene-1,2,4-triol namespace: reaction xref: KEGG:R01630 "KEGG reaction" xref: RHEA:30042 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: part_of UPa:UER00956 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01631 name: 3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R01631 "KEGG reaction" xref: METACYC:PROTOCATECHUATE-34-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10087 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00264 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1 [Term] id: UPa:UCR01635 name: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO(2) namespace: reaction xref: KEGG:R01635 "KEGG reaction" xref: METACYC:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24187 "Rhea reaction" relationship: has_input_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00230 {cardinality="1"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:UER00730 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 3/3 [Term] id: UPa:UCR01639 name: ATP + D-xylulose = ADP + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01639 "KEGG reaction" xref: METACYC:XYLULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10967 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00578 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 5/5 [Term] id: UPa:UCR01641 name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01641 "KEGG reaction" xref: METACYC:1TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10511 "Rhea reaction" relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC00117 {cardinality="1"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00413 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 1/3 [Term] id: UPa:UCR01647 name: pyruvate + succinate semialdehyde = 2,4-dihydroxyhept-2-enedioic acid namespace: reaction xref: KEGG:R01647 "KEGG reaction" xref: RHEA:25791 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: part_of UPa:UER00422 {cardinality="1", direction="RL", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 7/7 [Term] id: UPa:UCR01648 name: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde namespace: reaction xref: KEGG:R01648 "KEGG reaction" xref: METACYC:GABATRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23355 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00232 {cardinality="1"} ! succinate semialdehyde relationship: part_of UPa:UER00293 {cardinality="1", direction="LR", order="1"} ! succinate semialdehyde from 4-aminobutanoate: step 1/1 [Term] id: UPa:UCR01651 name: 4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-isovaleryl-CoA + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R01651 "KEGG reaction" xref: METACYC:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25180 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: part_of UPa:UER00859 {cardinality="1", direction="LR", order="1"} ! 3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1 [Term] id: UPa:UCR01652 name: 4-methyl-2-oxopentanoate + CO(2) = 3-carboxy-4-methyl-2-oxopentanoate namespace: reaction xref: KEGG:R01652 "KEGG reaction" xref: METACYC:RXN-7800 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25081 "Rhea reaction" relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00233 {cardinality="1"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate relationship: part_of UPa:UER00072 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 [Term] id: UPa:UCR01658 name: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate namespace: reaction xref: KEGG:R01658 "KEGG reaction" xref: METACYC:GPPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22411 "Rhea reaction" relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: part_of UPa:UER00368 {cardinality="1", direction="LR", order="1"} ! geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR01676 name: H(2)O + guanine = NH(3) + xanthine namespace: reaction xref: KEGG:R01676 "KEGG reaction" xref: METACYC:GUANINE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14668 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00242 {cardinality="1"} ! guanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UER00660 {cardinality="1", direction="LR", order="1"} ! xanthine from guanine: step 1/1 [Term] id: UPa:UCR01681 name: H(2)O + NAD(+) + hypotaurine = H(+) + NADH + taurine namespace: reaction xref: KEGG:R01681 "KEGG reaction" xref: METACYC:HYPOTAURINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17388 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UER00539 {cardinality="1", direction="LR", order="1"} ! taurine from hypotaurine: step 1/1 [Term] id: UPa:UCR01682 name: L-cysteate = CO(2) + taurine namespace: reaction xref: KEGG:R01682 "KEGG reaction" xref: METACYC:CYSTAUR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25224 "Rhea reaction" relationship: has_input_compound UPa:UPC00506 {cardinality="1"} ! L-cysteate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: part_of UPa:UER00541 {cardinality="1", direction="LR", order="1"} ! taurine from L-cysteine: step 2/2 [Term] id: UPa:UCR01707 name: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH namespace: reaction xref: KEGG:R01707 "KEGG reaction" xref: METACYC:PYRIDOXAL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21339 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone relationship: part_of UPa:UER00588 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 1/2 [Term] id: UPa:UCR01708 name: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal namespace: reaction xref: KEGG:R01708 "KEGG reaction" xref: METACYC:PYRIDOXINE-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16132 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00307 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (dehydrogenase route): step 1/1 [Term] id: UPa:UCR01711 name: O(2) + pyridoxine = H(2)O(2) + pyridoxal namespace: reaction xref: KEGG:R01711 "KEGG reaction" xref: METACYC:PYRIDOXINE-4-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15036 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00590 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxine (oxidase route): step 1/1 [Term] id: UPa:UCR01712 name: pyridoxamine + pyruvate = L-alanine + pyridoxal namespace: reaction xref: KEGG:R01712 "KEGG reaction" xref: METACYC:2.6.1.30-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12844 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00250 {cardinality="1"} ! pyridoxal relationship: part_of UPa:UER00306 {cardinality="1", direction="LR", order="1"} ! pyridoxal from pyridoxamine: step 1/1 [Term] id: UPa:UCR01714 name: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate namespace: reaction xref: KEGG:R01714 "KEGG reaction" xref: METACYC:CHORISMATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21023 "Rhea reaction" relationship: has_input_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: part_of UPa:UER00090 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7 [Term] id: UPa:UCR01715 name: chorismate = prephenate namespace: reaction xref: KEGG:R01715 "KEGG reaction" xref: METACYC:CHORISMATEMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13900 "Rhea reaction" relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UER00203 {cardinality="1", direction="LR", order="1"} ! prephenate from chorismate: step 1/1 [Term] id: UPa:UCR01717 name: chorismate = isochorismate namespace: reaction xref: KEGG:R01717 "KEGG reaction" xref: METACYC:ISOCHORSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18988 "Rhea reaction" relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00885 {cardinality="1"} ! isochorismate relationship: part_of UPa:UER00163 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7 [Term] id: UPa:UCR01720 name: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH namespace: reaction xref: KEGG:R01720 "KEGG reaction" xref: METACYC:RXN-7637 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12239 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: part_of UPa:UER01011 {cardinality="1", direction="LR", order="1"} ! 6-hydroxynicotinate from nicotinate: step 1/1 [Term] id: UPa:UCR01724 name: ADP + diphosphate + nicotinate D-ribonucleotide + phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(+) + H(2)O + nicotinate namespace: reaction xref: KEGG:R01724 "KEGG reaction" xref: METACYC:NICOTINATEPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13396 "Rhea reaction" xref: RHEA:36166 "Rhea reaction" relationship: has_input_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: part_of UPa:UER00457 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from nicotinate: step 1/1 [Term] id: UPa:UCR01728 name: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADH namespace: reaction xref: KEGG:R01728 "KEGG reaction" xref: METACYC:PREPHENATEDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13872 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00961 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01730 name: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R01730 "KEGG reaction" xref: METACYC:PREPHENATE-DEHYDROGENASE-NADP+-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21643 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: part_of UPa:UER00962 {cardinality="1", direction="LR", order="1"} ! (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1 [Term] id: UPa:UCR01731 name: L-arogenate + oxaloacetate = L-aspartate + prephenate namespace: reaction xref: KEGG:R01731 "KEGG reaction" xref: METACYC:PREPHENATE-ASP-TRANSAMINE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20448 "Rhea reaction" relationship: has_input_compound UPa:UPC00036 {cardinality="1"} ! oxaloacetate relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UER00342 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Asp route): step 1/1 [Term] id: UPa:UCR01736 name: (R)-S-lactoylglutathione + H(2)O = (R)-lactate + glutathione namespace: reaction xref: KEGG:R01736 "KEGG reaction" xref: METACYC:GLYOXII-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25248 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00256 {cardinality="1"} ! (R)-lactate relationship: part_of UPa:UER00676 {cardinality="1", direction="LR", order="1"} ! (R)-lactate from methylglyoxal: step 2/2 [Term] id: UPa:UCR01745 name: D-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH namespace: reaction xref: KEGG:R01745 "KEGG reaction" xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18848 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00973 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01747 name: D-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH namespace: reaction xref: KEGG:R01747 "KEGG reaction" xref: METACYC:RXN0-5289 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:TSA-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18844 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00974 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01749 name: CO(2) + D-glycerate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R01749 "KEGG reaction" xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:13156 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00981 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01750 name: CO(2) + D-glycerate + NADP(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADPH namespace: reaction xref: KEGG:R01750 "KEGG reaction" xref: METACYC:1.1.1.92-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13160 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00982 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01751 name: L-tartrate = CO(2) + D-glycerate namespace: reaction xref: KEGG:R01751 "KEGG reaction" xref: METACYC:TARTRATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13320 "Rhea reaction" relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00258 {cardinality="1"} ! D-glycerate relationship: part_of UPa:UER00803 {cardinality="1", direction="LR", order="1"} ! D-glycerate from L-tartrate: step 1/1 [Term] id: UPa:UCR01757 name: L-arabinose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH namespace: reaction xref: KEGG:R01757 "KEGG reaction" xref: METACYC:L-ARABINOSE-1-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17928 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone relationship: part_of UPa:UER00568 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 1/3 [Term] id: UPa:UCR01758 name: L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH namespace: reaction xref: KEGG:R01758 "KEGG reaction" xref: METACYC:RXN-14102 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25228 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: part_of UPa:UER00969 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01759 name: L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH namespace: reaction xref: KEGG:R01759 "KEGG reaction" xref: METACYC:RXN-8772 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25232 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: part_of UPa:UER00970 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01761 name: L-arabinose = L-ribulose namespace: reaction xref: KEGG:R01761 "KEGG reaction" xref: METACYC:ARABISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14824 "Rhea reaction" relationship: has_input_compound UPa:UPC00259 {cardinality="1"} ! L-arabinose relationship: has_output_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose relationship: part_of UPa:UER00565 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3 [Term] id: UPa:UCR01764 name: phenylglyoxylate = CO(2) + benzaldehyde namespace: reaction xref: KEGG:R01764 "KEGG reaction" xref: METACYC:BENZOYLFORMATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23371 "Rhea reaction" relationship: has_input_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00261 {cardinality="1"} ! benzaldehyde relationship: part_of UPa:UER00854 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 3/4 [Term] id: UPa:UCR01768 name: H(2)O + NAD(+) + hypoxanthine = H(+) + NADH + xanthine namespace: reaction xref: KEGG:R01768 "KEGG reaction" xref: METACYC:RXN-7682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24673 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00262 {cardinality="1"} ! hypoxanthine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UER00661 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 1/2 [Term] id: UPa:UCR01771 name: ATP + L-homoserine = ADP + O-phospho-L-homoserine namespace: reaction xref: KEGG:R01771 "KEGG reaction" xref: METACYC:HOMOSERKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13988 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01102 {cardinality="1"} ! O-phospho-L-homoserine relationship: part_of UPa:UER00064 {cardinality="1", direction="LR", order="1"} ! L-threonine from L-aspartate: step 4/5 [Term] id: UPa:UCR01773 name: L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH namespace: reaction xref: KEGG:R01773 "KEGG reaction" xref: RHEA:15760 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: part_of UPa:UER00949 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01775 name: L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH namespace: reaction xref: KEGG:R01775 "KEGG reaction" xref: METACYC:HOMOSERDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15764 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: part_of UPa:UER00950 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR01776 name: L-homoserine + acetyl-CoA = CoA + O-acetyl-L-homoserine namespace: reaction xref: KEGG:R01776 "KEGG reaction" xref: METACYC:HOMOSERINE-O-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13704 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: part_of UPa:UER00074 {cardinality="1", direction="LR", order="1"} ! O-acetyl-L-homoserine from L-homoserine: step 1/1 [Term] id: UPa:UCR01777 name: L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine namespace: reaction xref: KEGG:R01777 "KEGG reaction" xref: METACYC:HOMSUCTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22011 "Rhea reaction" relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: part_of UPa:UER00075 {cardinality="1", direction="LR", order="1"} ! O-succinyl-L-homoserine from L-homoserine: step 1/1 [Term] id: UPa:UCR01784 name: 2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate namespace: reaction xref: KEGG:R01784 "KEGG reaction" xref: METACYC:4.1.2.18-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18548 "Rhea reaction" relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde relationship: part_of UPa:UER00571 {cardinality="1", direction="LR", order="1"} ! glycolaldehyde and pyruvate from 2-dehydro-3-deoxy-L-arabinonate: step 1/1 [Term] id: UPa:UCR01793 name: H(+) + NADH + dihydrobiopterin = NAD(+) + tetrahydrobiopterin namespace: reaction xref: KEGG:R01793 "KEGG reaction" xref: METACYC:1.5.1.34-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: METACYC:RXN-7909 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17872 "Rhea reaction" xref: RHEA:32254 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: part_of UPa:UER00993 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01794 name: H(+) + NADPH + dihydrobiopterin = NADP(+) + tetrahydrobiopterin namespace: reaction xref: KEGG:R01794 "KEGG reaction" xref: RHEA:32250 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00268 {cardinality="1"} ! dihydrobiopterin relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: part_of UPa:UER00994 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR01797 name: CDP-diacylglycerol + H(2)O = CMP + phosphatidate namespace: reaction xref: KEGG:R01797 "KEGG reaction" xref: METACYC:CDPDIGLYPYPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15224 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: part_of UPa:UER00664 {cardinality="1", direction="LR", order="1"} ! phosphatidate from CDP-diacylglycerol: step 1/1 [Term] id: UPa:UCR01799 name: CTP + phosphatidate = CDP-diacylglycerol + diphosphate namespace: reaction xref: KEGG:R01799 "KEGG reaction" xref: METACYC:CDPDIGLYSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16232 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: part_of UPa:UER00614 {cardinality="1", direction="LR", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3 [Term] id: UPa:UCR01800 name: CDP-diacylglycerol + L-serine = CMP + phosphatidylserine namespace: reaction xref: KEGG:R01800 "KEGG reaction" xref: METACYC:PHOSPHASERSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16916 "Rhea reaction" relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine relationship: part_of UPa:UER00615 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 1/2 [Term] id: UPa:UCR01801 name: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + phosphatidylglycerophosphate namespace: reaction xref: KEGG:R01801 "KEGG reaction" xref: METACYC:PHOSPHAGLYPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12596 "Rhea reaction" relationship: has_input_compound UPa:UPC00093 {cardinality="1"} ! sn-glycerol 3-phosphate relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate relationship: part_of UPa:UER00503 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 1/2 [Term] id: UPa:UCR01811 name: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate namespace: reaction xref: KEGG:R01811 "KEGG reaction" xref: METACYC:ACNEULY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23299 "Rhea reaction" relationship: has_input_compound UPa:UPC00270 {cardinality="1"} ! N-acetylneuraminate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine relationship: part_of UPa:UER00680 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 1/5 [Term] id: UPa:UCR01812 name: 2 NADP(+) + tetrahydrobiopterin = 2 H(+) + 2 NADPH + biopterin namespace: reaction xref: KEGG:R01812 "KEGG reaction" xref: METACYC:1.1.1.253-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19512 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06313 {cardinality="1"} ! biopterin relationship: part_of UPa:UER00822 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from biopterin: step 1/1 [Term] id: UPa:UCR01813 name: NADP(+) + tetrahydrobiopterin = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH namespace: reaction xref: KEGG:R01813 "KEGG reaction" xref: METACYC:RXN-8854 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42503 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: part_of UPa:UER00821 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 3/3 [Term] id: UPa:UCR01818 name: D-mannose 6-phosphate = alpha-D-mannose 1-phosphate namespace: reaction xref: KEGG:R01818 "KEGG reaction" xref: METACYC:PHOSMANMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11143 "Rhea reaction" relationship: has_input_compound UPa:UPC00275 {cardinality="1"} ! D-mannose 6-phosphate relationship: has_output_compound UPa:UPC00636 {cardinality="1"} ! alpha-D-mannose 1-phosphate relationship: part_of UPa:UER00424 {cardinality="1", direction="LR", order="1"} ! alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2 [Term] id: UPa:UCR01825 name: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + H(+) + NADH namespace: reaction xref: KEGG:R01825 "KEGG reaction" xref: METACYC:ERYTH4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12059 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate relationship: part_of UPa:UER00309 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5 [Term] id: UPa:UCR01826 name: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate namespace: reaction xref: KEGG:R01826 "KEGG reaction" xref: METACYC:DAHPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14720 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: part_of UPa:UER00084 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7 [Term] id: UPa:UCR01827 name: D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate namespace: reaction xref: KEGG:R01827 "KEGG reaction" xref: METACYC:TRANSALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17056 "Rhea reaction" relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate relationship: part_of UPa:UER00414 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3 [Term] id: UPa:UCR01830 name: D-glyceraldehyde 3-phosphate + beta-D-fructose 6-phosphate = D-erythrose 4-phosphate + D-xylulose 5-phosphate namespace: reaction xref: KEGG:R01830 "KEGG reaction" xref: METACYC:2TRANSKETO-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:27629 "Rhea reaction" relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_input_compound UPa:UPC05345 {cardinality="1"} ! beta-D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00279 {cardinality="1"} ! D-erythrose 4-phosphate relationship: part_of UPa:UER00415 {cardinality="1", direction="RL", order="1"} ! D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 3/3 [Term] id: UPa:UCR01859 name: ATP + bicarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + phosphate namespace: reaction xref: KEGG:R01859 "KEGG reaction" xref: METACYC:PROPIONYL-COA-CARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23723 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA relationship: part_of UPa:UER00908 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from propanoyl-CoA: step 1/3 [Term] id: UPa:UCR01867 name: (S)-dihydroorotate + fumarate = orotate + succinate namespace: reaction xref: KEGG:R01867 "KEGG reaction" xref: METACYC:RXN-9929 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15444 "Rhea reaction" relationship: has_input_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UER00118 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (O2 route): step 1/1 [Term] id: UPa:UCR01868 name: (S)-dihydroorotate + Quinone = Hydroquinone + orotate namespace: reaction xref: KEGG:R01868 "KEGG reaction" xref: METACYC:DIHYDROOROTATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18076 "Rhea reaction" xref: RHEA:30190 "Rhea reaction" relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER00946 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (quinone route): step 1/1 [Term] id: UPa:UCR01869 name: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate namespace: reaction xref: KEGG:R01869 "KEGG reaction" xref: METACYC:OROTATE-REDUCTASE-NADH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13516 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UER00945 {cardinality="1", direction="LR", order="1"} ! orotate from (S)-dihydroorotate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01870 name: diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate namespace: reaction xref: KEGG:R01870 "KEGG reaction" xref: METACYC:OROPRIBTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10383 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC01103 {cardinality="1"} ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00295 {cardinality="1"} ! orotate relationship: part_of UPa:UER00119 {cardinality="1", direction="RL", order="1"} ! UMP from orotate: step 1/2 [Term] id: UPa:UCR01872 name: D-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH namespace: reaction xref: KEGG:R01872 "KEGG reaction" xref: METACYC:QUINATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: METACYC:RXN-7967 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:22367 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: part_of UPa:UER00176 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1 [Term] id: UPa:UCR01873 name: D-quinate + pyrroloquinoline quinone = 3-dehydroquinate + pyrroloquinoline quinol namespace: reaction xref: KEGG:R01873 "KEGG reaction" xref: METACYC:1.1.99.25-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23675 "Rhea reaction" relationship: has_input_compound UPa:UPC00113 {cardinality="1"} ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00296 {cardinality="1"} ! D-quinate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC01359 {cardinality="1"} ! pyrroloquinoline quinol relationship: part_of UPa:UER00177 {cardinality="1", direction="LR", order="1"} ! 3-dehydroquinate from D-quinate (PQQ route): step 1/1 [Term] id: UPa:UCR01876 name: phosphate + uridine = alpha-D-ribose 1-phosphate + uracil namespace: reaction xref: KEGG:R01876 "KEGG reaction" xref: METACYC:URPHOS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24391 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: has_output_compound UPa:UPC00106 {cardinality="1"} ! uracil relationship: has_output_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00633 {cardinality="1", direction="LR", order="1"} ! uracil from uridine (phosphorylase route): step 1/1 [Term] id: UPa:UCR01878 name: H(2)O + cytidine = NH(3) + uridine namespace: reaction xref: KEGG:R01878 "KEGG reaction" xref: METACYC:CYTIDEAM2-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16072 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00475 {cardinality="1"} ! cytidine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00299 {cardinality="1"} ! uridine relationship: part_of UPa:UER00632 {cardinality="1", direction="LR", order="1"} ! uridine from cytidine: step 1/1 [Term] id: UPa:UCR01883 name: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine namespace: reaction xref: KEGG:R01883 "KEGG reaction" xref: METACYC:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10659 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00581 {cardinality="1"} ! guanidinoacetate relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00300 {cardinality="1"} ! creatine relationship: part_of UPa:UER00580 {cardinality="1", direction="LR", order="1"} ! creatine from L-arginine and glycine: step 2/2 [Term] id: UPa:UCR01890 name: CTP + phosphocholine = CDP-choline + diphosphate namespace: reaction xref: KEGG:R01890 "KEGG reaction" xref: METACYC:2.7.7.15-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19000 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00307 {cardinality="1"} ! CDP-choline relationship: part_of UPa:UER00739 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from phosphocholine: step 1/2 [Term] id: UPa:UCR01896 name: NAD(+) + xylitol = D-xylulose + H(+) + NADH namespace: reaction xref: KEGG:R01896 "KEGG reaction" xref: METACYC:D-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20436 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00310 {cardinality="1"} ! D-xylulose relationship: part_of UPa:UER00577 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5 [Term] id: UPa:UCR01900 name: isocitrate = H(2)O + cis-aconitate namespace: reaction xref: KEGG:R01900 "KEGG reaction" xref: METACYC:ACONITATEHYDR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22147 "Rhea reaction" relationship: has_input_compound UPa:UPC00311 {cardinality="1"} ! isocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00417 {cardinality="1"} ! cis-aconitate relationship: part_of UPa:UER00718 {cardinality="1", direction="RL", order="2"} ! isocitrate from oxaloacetate: step 2/2 [Term] id: UPa:UCR01903 name: L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH namespace: reaction xref: KEGG:R01903 "KEGG reaction" xref: METACYC:L-ARABINITOL-4-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16384 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00532 {cardinality="1"} ! L-arabinitol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose relationship: part_of UPa:UER00575 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5 [Term] id: UPa:UCR01904 name: NADP(+) + xylitol = H(+) + L-xylulose + NADPH namespace: reaction xref: KEGG:R01904 "KEGG reaction" xref: METACYC:L-XYLULOSE-REDUCTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17028 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00379 {cardinality="1"} ! xylitol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00312 {cardinality="1"} ! L-xylulose relationship: part_of UPa:UER00576 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5 [Term] id: UPa:UCR01908 name: oxalyl-CoA = CO(2) + formyl-CoA namespace: reaction xref: KEGG:R01908 "KEGG reaction" xref: METACYC:OXALYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19336 "Rhea reaction" relationship: has_input_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA relationship: part_of UPa:UER00599 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 2/2 [Term] id: UPa:UCR01909 name: ATP + pyridoxine = ADP + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R01909 "KEGG reaction" xref: METACYC:PNKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25111 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00300 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from pyridoxine: step 1/1 [Term] id: UPa:UCR01911 name: phosphate + pyridoxine = H(2)O + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R01911 "KEGG reaction" xref: RHEA:25115 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00314 {cardinality="1"} ! pyridoxine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00303 {cardinality="1", direction="RL", order="1"} ! pyridoxine from pyridoxine 5'-phosphate: step 1/1 [Term] id: UPa:UCR01915 name: H(2)O + acceptor + spermidine = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor namespace: reaction xref: KEGG:R01915 "KEGG reaction" xref: METACYC:SPERMIDINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14276 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UER00291 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1 [Term] id: UPa:UCR01920 name: S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine namespace: reaction xref: KEGG:R01920 "KEGG reaction" xref: METACYC:SPERMIDINESYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12724 "Rhea reaction" relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: part_of UPa:UER00314 {cardinality="1", direction="LR", order="1"} ! spermidine from putrescine: step 1/1 [Term] id: UPa:UCR01936 name: 2-oxaloglutaric acid = 2-oxoadipate + CO(2) namespace: reaction xref: KEGG:R01936 "KEGG reaction" relationship: has_input_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="2"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 [Term] id: UPa:UCR01939 name: 2-oxoglutarate + L-alpha-aminoadipate = 2-oxoadipate + L-glutamate namespace: reaction xref: KEGG:R01939 "KEGG reaction" xref: METACYC:2-AMINOADIPATE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12604 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: part_of UPa:UER00031 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 5/5 relationship: part_of UPa:UER00838 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 4/6 [Term] id: UPa:UCR01940 name: 2-oxoadipate + Enzyme N6-(lipoyl)lysine = CO(2) + S(8)-glutaryldihydrolipoamide namespace: reaction xref: KEGG:R01940 "KEGG reaction" xref: RHEA:12191 "Rhea reaction" xref: RHEA:15216 "Rhea reaction" relationship: has_input_compound UPa:UPC00322 {cardinality="1"} ! 2-oxoadipate relationship: has_input_compound UPa:UPC15972 {cardinality="1"} ! Enzyme N6-(lipoyl)lysine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide relationship: part_of UPa:UER00839 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 5/6 [Term] id: UPa:UCR01954 name: ATP + L-aspartate + L-citrulline = (N(omega)-L-arginino)succinate + AMP + diphosphate namespace: reaction xref: KEGG:R01954 "KEGG reaction" xref: METACYC:ARGSUCCINSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10935 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1"} ! L-citrulline relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC03406 {cardinality="1"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:UER00113 {cardinality="1", direction="LR", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate: step 2/3 relationship: part_of UPa:UER00272 {cardinality="1", direction="LR", order="1"} ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1 [Term] id: UPa:UCR01956 name: 2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate namespace: reaction xref: KEGG:R01956 "KEGG reaction" xref: METACYC:2.6.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20967 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: part_of UPa:UER00726 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 1/2 [Term] id: UPa:UCR01959 name: H(2)O + N-formyl-N-kynurenine = L-kynurenine + formate namespace: reaction xref: KEGG:R01959 "KEGG reaction" xref: METACYC:ARYLFORMAMIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13012 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02700 {cardinality="1"} ! N-formyl-N-kynurenine relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: part_of UPa:UER00454 {cardinality="1", direction="LR", order="1"} ! L-kynurenine from L-tryptophan: step 2/2 [Term] id: UPa:UCR01960 name: H(+) + L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R01960 "KEGG reaction" xref: METACYC:KYNURENINE-3-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20548 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00328 {cardinality="1"} ! L-kynurenine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine relationship: part_of UPa:UER00328 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 1/3 [Term] id: UPa:UCR01978 name: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = H(2)O + acetoacetyl-CoA + acetyl-CoA namespace: reaction xref: KEGG:R01978 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10191 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1"} ! acetoacetyl-CoA relationship: part_of UPa:UER00102 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 2/3 [Term] id: UPa:UCR01993 name: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate namespace: reaction xref: KEGG:R01993 "KEGG reaction" xref: METACYC:DIHYDROOROT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24299 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00337 {cardinality="1"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00438 {cardinality="1"} ! N-carbamoyl-L-aspartate relationship: part_of UPa:UER00117 {cardinality="1", direction="RL", order="1"} ! (S)-dihydroorotate from bicarbonate: step 3/3 [Term] id: UPa:UCR02003 name: geranyl diphosphate + isopentenyl diphosphate = diphosphate + farnesyl diphosphate namespace: reaction xref: KEGG:R02003 "KEGG reaction" xref: METACYC:FPPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19364 "Rhea reaction" relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: part_of UPa:UER00369 {cardinality="1", direction="LR", order="1"} ! farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR02013 name: geranyl diphosphate = (4S)-limonene + diphosphate namespace: reaction xref: KEGG:R02013 "KEGG reaction" xref: METACYC:4.2.3.16-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12872 "Rhea reaction" relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00521 {cardinality="1"} ! (4S)-limonene relationship: part_of UPa:UER00925 {cardinality="1", direction="LR", order="1"} ! (4S)-limonene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR02021 name: 3'-phospho-5'-adenylyl sulfate + thioredoxin = adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide namespace: reaction xref: KEGG:R02021 "KEGG reaction" xref: METACYC:1.8.4.8-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11727 "Rhea reaction" relationship: has_input_compound UPa:UPC00053 {cardinality="1"} ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00342 {cardinality="1"} ! thioredoxin relationship: has_output_compound UPa:UPC00054 {cardinality="1"} ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00343 {cardinality="1"} ! thioredoxin disulfide relationship: part_of UPa:UER00206 {cardinality="1", direction="LR", order="1"} ! sulfite from sulfate: step 3/3 [Term] id: UPa:UCR02029 name: H(2)O + phosphatidylglycerophosphate = phosphate + phosphatidylglycerol namespace: reaction xref: KEGG:R02029 "KEGG reaction" xref: METACYC:PGPPHOSPHA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:33754 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03892 {cardinality="1"} ! phosphatidylglycerophosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00344 {cardinality="1"} ! phosphatidylglycerol relationship: part_of UPa:UER00504 {cardinality="1", direction="LR", order="1"} ! phosphatidylglycerol from CDP-diacylglycerol: step 2/2 [Term] id: UPa:UCR02035 name: D-glucono-1,5-lactone 6-phosphate + H(2)O = 6-phospho-D-gluconate namespace: reaction xref: KEGG:R02035 "KEGG reaction" xref: METACYC:6PGLUCONOLACT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12559 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01236 {cardinality="1"} ! D-glucono-1,5-lactone 6-phosphate relationship: has_output_compound UPa:UPC00345 {cardinality="1"} ! 6-phospho-D-gluconate relationship: part_of UPa:UER00409 {cardinality="1", direction="LR", order="1"} ! D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 [Term] id: UPa:UCR02037 name: S-adenosyl-L-methionine + phosphoethanolamine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R02037 "KEGG reaction" xref: METACYC:2.1.1.103-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20368 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="1"} ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR02038 name: CTP + phosphoethanolamine = CDP-ethanolamine + diphosphate namespace: reaction xref: KEGG:R02038 "KEGG reaction" xref: METACYC:2.7.7.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24595 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00346 {cardinality="1"} ! phosphoethanolamine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine relationship: part_of UPa:UER00742 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 2/3 [Term] id: UPa:UCR02055 name: phosphatidylserine = CO(2) + phosphatidylethanolamine namespace: reaction xref: KEGG:R02055 "KEGG reaction" xref: METACYC:PHOSPHASERDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20831 "Rhea reaction" relationship: has_input_compound UPa:UPC02737 {cardinality="1"} ! phosphatidylserine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: part_of UPa:UER00616 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from CDP-diacylglycerol: step 2/2 [Term] id: UPa:UCR02057 name: 1,2-diacyl-sn-glycerol + CDP-ethanolamine = CMP + phosphatidylethanolamine namespace: reaction xref: KEGG:R02057 "KEGG reaction" xref: METACYC:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:32946 "Rhea reaction" relationship: has_input_compound UPa:UPC00570 {cardinality="1"} ! CDP-ethanolamine relationship: has_input_compound UPa:UPC00641 {cardinality="1"} ! 1,2-diacyl-sn-glycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00350 {cardinality="1"} ! phosphatidylethanolamine relationship: part_of UPa:UER00743 {cardinality="1", direction="LR", order="1"} ! phosphatidylethanolamine from ethanolamine: step 3/3 [Term] id: UPa:UCR02058 name: acetyl-CoA + alpha-D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02058 "KEGG reaction" xref: METACYC:GLUCOSAMINEPNACETYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10295 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: part_of UPa:UER00529 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2 [Term] id: UPa:UCR02059 name: H(2)O + N-acetyl-D-glucosamine 6-phosphate = acetate + alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02059 "KEGG reaction" xref: METACYC:NAG6PDEACET-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22939 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00683 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 4/5 [Term] id: UPa:UCR02060 name: alpha-D-glucosamine 1-phosphate = alpha-D-glucosamine 6-phosphate namespace: reaction xref: KEGG:R02060 "KEGG reaction" xref: METACYC:5.4.2.10-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23427 "Rhea reaction" relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00352 {cardinality="1"} ! alpha-D-glucosamine 6-phosphate relationship: part_of UPa:UER00531 {cardinality="1", direction="RL", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 1/2 [Term] id: UPa:UCR02061 name: farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate namespace: reaction xref: KEGG:R02061 "KEGG reaction" xref: METACYC:FARNESYLTRANSTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17656 "Rhea reaction" relationship: has_input_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: part_of UPa:UER00564 {cardinality="1", direction="LR", order="1"} ! geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1 [Term] id: UPa:UCR02065 name: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate namespace: reaction xref: KEGG:R02065 "KEGG reaction" xref: METACYC:2.5.1.32-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22299 "Rhea reaction" relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="1"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR02080 name: L-dopa = CO(2) + dopamine namespace: reaction xref: KEGG:R02080 "KEGG reaction" xref: METACYC:RXN66-221 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12275 "Rhea reaction" relationship: has_input_compound UPa:UPC00355 {cardinality="1"} ! L-dopa relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: part_of UPa:UER00734 {cardinality="1", direction="LR", order="1"} ! dopamine from L-tyrosine: step 2/2 [Term] id: UPa:UCR02081 name: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH namespace: reaction xref: KEGG:R02081 "KEGG reaction" xref: METACYC:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14836 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UER00367 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1 [Term] id: UPa:UCR02082 name: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH namespace: reaction xref: KEGG:R02082 "KEGG reaction" xref: METACYC:1.1.1.34-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15992 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:UER00103 {cardinality="1", direction="RL", order="1"} ! (R)-mevalonate from acetyl-CoA: step 3/3 [Term] id: UPa:UCR02085 name: (S)-3-hydroxy-3-methylglutaryl-CoA = 3-methylglutaconyl-CoA + H(2)O namespace: reaction xref: KEGG:R02085 "KEGG reaction" xref: METACYC:METHYLGLUTACONYL-COA-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21539 "Rhea reaction" relationship: has_input_compound UPa:UPC00356 {cardinality="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA relationship: part_of UPa:UER00862 {cardinality="1", direction="RL", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3 [Term] id: UPa:UCR02087 name: N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate namespace: reaction xref: KEGG:R02087 "KEGG reaction" xref: METACYC:NANE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25260 "Rhea reaction" relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate relationship: part_of UPa:UER00682 {cardinality="1", direction="RL", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 3/5 [Term] id: UPa:UCR02100 name: H(2)O + dUTP = dUMP + diphosphate namespace: reaction xref: KEGG:R02100 "KEGG reaction" xref: METACYC:DUTP-PYROP-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10251 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00460 {cardinality="1"} ! dUTP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: part_of UPa:UER00666 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 2/2 [Term] id: UPa:UCR02103 name: H(2)O + NAD(+) + xanthine = H(+) + NADH + urate namespace: reaction xref: KEGG:R02103 "KEGG reaction" xref: METACYC:RXN0-901 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16672 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: part_of UPa:UER00662 {cardinality="1", direction="LR", order="1"} ! urate from hypoxanthine: step 2/2 [Term] id: UPa:UCR02106 name: H(2)O + O(2) + urate = 5-hydroxyisouric acid + H(2)O(2) namespace: reaction xref: KEGG:R02106 "KEGG reaction" xref: METACYC:URATE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21371 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00366 {cardinality="1"} ! urate relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid relationship: part_of UPa:UER00650 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 1/3 [Term] id: UPa:UCR02133 name: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) namespace: reaction xref: KEGG:R02133 "KEGG reaction" xref: METACYC:THIAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17512 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: part_of UPa:UER00805 {cardinality="1", direction="LR", order="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1 [Term] id: UPa:UCR02134 name: ATP + thiamine = ADP + thiamine phosphate namespace: reaction xref: KEGG:R02134 "KEGG reaction" xref: METACYC:THIKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12015 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00378 {cardinality="1"} ! thiamine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: part_of UPa:UER00596 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from thiamine: step 1/1 [Term] id: UPa:UCR02139 name: H(2)O + barbiturate = 3-oxo-3-ureidopropanoic acid namespace: reaction xref: KEGG:R02139 "KEGG reaction" xref: METACYC:BARBITURASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18656 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00813 {cardinality="1"} ! barbiturate relationship: has_output_compound UPa:UPC15607 {cardinality="1"} ! 3-oxo-3-ureidopropanoic acid relationship: part_of UPa:UER00644 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 2/3 [Term] id: UPa:UCR02142 name: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine namespace: reaction xref: KEGG:R02142 "KEGG reaction" xref: METACYC:XANPRIBOSYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10803 "Rhea reaction" relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC00655 {cardinality="1"} ! XMP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00385 {cardinality="1"} ! xanthine relationship: part_of UPa:UER00658 {cardinality="1", direction="RL", order="1"} ! XMP from xanthine: step 1/1 [Term] id: UPa:UCR02164 name: Quinone + succinate = Hydroquinone + fumarate namespace: reaction xref: KEGG:R02164 "KEGG reaction" xref: METACYC:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13716 "Rhea reaction" xref: RHEA:40526 "Rhea reaction" relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_input_compound UPa:UPC15602 {cardinality="1"} ! Quinone relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC15603 {cardinality="1"} ! Hydroquinone relationship: part_of UPa:UER01006 {cardinality="1", direction="LR", order="1"} ! fumarate from succinate (eukaryal route): step 1/1 [Term] id: UPa:UCR02199 name: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R02199 "KEGG reaction" xref: METACYC:BRANCHED-CHAINAMINOTRANSFERILEU-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24804 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00407 {cardinality="1"} ! L-isoleucine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00058 {cardinality="1", direction="RL", order="1"} ! L-isoleucine from 2-oxobutanoate: step 4/4 [Term] id: UPa:UCR02236 name: 7,8-dihydrofolate + NADP(+) = H(+) + NADPH + folate namespace: reaction xref: KEGG:R02236 "KEGG reaction" xref: RHEA:31106 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00504 {cardinality="1"} ! folate relationship: part_of UPa:UER00818 {cardinality="1", direction="RL", order="1"} ! 7,8-dihydrofolate from folate: step 1/1 [Term] id: UPa:UCR02237 name: 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + phosphate namespace: reaction xref: KEGG:R02237 "KEGG reaction" xref: METACYC:DIHYDROFOLATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23587 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00415 {cardinality="1"} ! 7,8-dihydrofolate relationship: part_of UPa:UER00157 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2 [Term] id: UPa:UCR02241 name: CoA + phosphatidate = 1-acyl-sn-glycerol 3-phosphate + acyl-CoA namespace: reaction xref: KEGG:R02241 "KEGG reaction" xref: METACYC:RXN-1623 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19712 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00416 {cardinality="1"} ! phosphatidate relationship: has_output_compound UPa:UPC00040 {cardinality="1"} ! acyl-CoA relationship: has_output_compound UPa:UPC00681 {cardinality="1"} ! 1-acyl-sn-glycerol 3-phosphate relationship: part_of UPa:UER00613 {cardinality="1", direction="RL", order="1"} ! CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3 [Term] id: UPa:UCR02245 name: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP namespace: reaction xref: KEGG:R02245 "KEGG reaction" xref: METACYC:MEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17068 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00418 {cardinality="1"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate relationship: part_of UPa:UER00098 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 1/3 [Term] id: UPa:UCR02253 name: H(+) + NADPH + O(2) + trans-cinnamate = H(2)O + NADP(+) + trans-4-coumarate namespace: reaction xref: KEGG:R02253 "KEGG reaction" xref: METACYC:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10611 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00423 {cardinality="1"} ! trans-cinnamate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00811 {cardinality="1"} ! trans-4-coumarate relationship: part_of UPa:UER00789 {cardinality="1", direction="LR", order="1"} ! trans-4-coumarate from trans-cinnamate: step 1/1 [Term] id: UPa:UCR02262 name: L-fuculose 1-phosphate = L-lactaldehyde + glycerone phosphate namespace: reaction xref: KEGG:R02262 "KEGG reaction" xref: METACYC:FUCPALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12936 "Rhea reaction" relationship: has_input_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde relationship: part_of UPa:UER00626 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3 [Term] id: UPa:UCR02263 name: L-rhamnulose 1-phosphate = L-lactaldehyde + glycerone phosphate namespace: reaction xref: KEGG:R02263 "KEGG reaction" xref: METACYC:RHAMNULPALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19692 "Rhea reaction" relationship: has_input_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00424 {cardinality="1"} ! L-lactaldehyde relationship: part_of UPa:UER00603 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 3/3 [Term] id: UPa:UCR02272 name: 5-aminolevulinate = (S)-4-amino-5-oxopentanoic acid namespace: reaction xref: KEGG:R02272 "KEGG reaction" xref: METACYC:GSAAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14268 "Rhea reaction" relationship: has_input_compound UPa:UPC00430 {cardinality="1"} ! 5-aminolevulinate relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid relationship: part_of UPa:UER00317 {cardinality="1", direction="RL", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2 [Term] id: UPa:UCR02274 name: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate namespace: reaction xref: KEGG:R02274 "KEGG reaction" xref: METACYC:VAGL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10215 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate relationship: part_of UPa:UER00845 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 5/6 [Term] id: UPa:UCR02276 name: 5-acetamidopentanoate + H(2)O = 5-aminopentanoate + acetate namespace: reaction xref: KEGG:R02276 "KEGG reaction" xref: METACYC:AMVAL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42515 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00431 {cardinality="1"} ! 5-aminopentanoate relationship: part_of UPa:UER00844 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 4/6 [Term] id: UPa:UCR02278 name: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O namespace: reaction xref: KEGG:R02278 "KEGG reaction" xref: METACYC:4.2.1.43-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17204 "Rhea reaction" relationship: has_input_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: part_of UPa:UER00572 {cardinality="1", direction="LR", order="1"} ! 2-oxoglutarate from 2-dehydro-3-deoxy-L-arabinonate: step 1/2 [Term] id: UPa:UCR02279 name: 5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + CO(2) + H(2)O namespace: reaction xref: KEGG:R02279 "KEGG reaction" xref: METACYC:4.2.1.41-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24611 "Rhea reaction" relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00433 {cardinality="1"} ! 2,5-dioxopentanoate relationship: part_of UPa:UER00628 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 2/2 [Term] id: UPa:UCR02282 name: L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate namespace: reaction xref: KEGG:R02282 "KEGG reaction" xref: METACYC:GLUTAMATE-N-ACETYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15352 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1"} ! L-ornithine relationship: has_output_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: part_of UPa:UER00111 {cardinality="1", direction="LR", order="1"} ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1 [Term] id: UPa:UCR02283 name: 2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R02283 "KEGG reaction" xref: METACYC:ACETYLORNTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18052 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00437 {cardinality="1"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: part_of UPa:UER00109 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 4/4 [Term] id: UPa:UCR02285 name: H(2)O + N-formimidoyl-L-glutamate = L-glutamate + formamide namespace: reaction xref: KEGG:R02285 "KEGG reaction" xref: METACYC:FORMIMINOGLUTAMASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22495 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00488 {cardinality="1"} ! formamide relationship: part_of UPa:UER00552 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1 [Term] id: UPa:UCR02286 name: H(2)O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH(3) namespace: reaction xref: KEGG:R02286 "KEGG reaction" xref: METACYC:FORMIMINOGLUTAMATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22835 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC01045 {cardinality="1"} ! N-formyl-L-glutamate relationship: part_of UPa:UER00553 {cardinality="1", direction="LR", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (deiminase route): step 1/2 [Term] id: UPa:UCR02287 name: 5-formiminotetrahydrofolate + L-glutamate = 5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate namespace: reaction xref: KEGG:R02287 "KEGG reaction" xref: METACYC:GLUTAMATE-FORMIMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15100 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00664 {cardinality="1"} ! 5-formiminotetrahydrofolate relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: part_of UPa:UER00555 {cardinality="1", direction="RL", order="1"} ! L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1 [Term] id: UPa:UCR02288 name: 4-imidazolone-5-propanoate + H(2)O = N-formimidoyl-L-glutamate namespace: reaction xref: KEGG:R02288 "KEGG reaction" xref: METACYC:IMIDAZOLONEPROPIONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23663 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC00439 {cardinality="1"} ! N-formimidoyl-L-glutamate relationship: part_of UPa:UER00551 {cardinality="1", direction="LR", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 3/3 [Term] id: UPa:UCR02291 name: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH namespace: reaction xref: KEGG:R02291 "KEGG reaction" xref: METACYC:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24287 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03082 {cardinality="1"} ! 4-phospho-L-aspartate relationship: part_of UPa:UER00016 {cardinality="1", direction="RL", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 2/4 relationship: part_of UPa:UER00463 {cardinality="1", direction="RL", order="1"} ! L-threonine from L-aspartate: step 2/5 relationship: part_of UPa:UER00464 {cardinality="1", direction="RL", order="1"} ! L-homoserine from L-aspartate: step 2/3 [Term] id: UPa:UCR02305 name: farnesyl diphosphate = diphosphate + pentalenene namespace: reaction xref: KEGG:R02305 "KEGG reaction" xref: METACYC:PENTALENENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18084 "Rhea reaction" relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC01841 {cardinality="1"} ! pentalenene relationship: part_of UPa:UER00581 {cardinality="1", direction="LR", order="1"} ! pentalenene from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR02307 name: farnesyl diphosphate = aristolochene + diphosphate namespace: reaction xref: KEGG:R02307 "KEGG reaction" xref: METACYC:ARISTOLOCHENE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19828 "Rhea reaction" relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC02004 {cardinality="1"} ! aristolochene relationship: part_of UPa:UER00582 {cardinality="1", direction="LR", order="1"} ! aristolochene from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR02313 name: H(2)O + NAD(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADH namespace: reaction xref: KEGG:R02313 "KEGG reaction" xref: METACYC:1.5.1.9-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24523 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00836 {cardinality="1", direction="LR", order="1"} ! glutaryl-CoA from L-lysine: step 2/6 [Term] id: UPa:UCR02315 name: H(2)O + NADP(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADPH namespace: reaction xref: KEGG:R02315 "KEGG reaction" xref: METACYC:RXN3O-127 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10023 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1"} ! saccharopine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00033 {cardinality="1", direction="RL", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 2/3 [Term] id: UPa:UCR02325 name: H(2)O + dCTP = NH(3) + dUTP namespace: reaction xref: KEGG:R02325 "KEGG reaction" xref: METACYC:DCTP-DEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22683 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00460 {cardinality="1"} ! dUTP relationship: part_of UPa:UER00665 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP (dUTP route): step 1/2 [Term] id: UPa:UCR02340 name: indoleglycerol phosphate = D-glyceraldehyde 3-phosphate + indole namespace: reaction xref: KEGG:R02340 "KEGG reaction" xref: METACYC:RXN0-2381 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14084 "Rhea reaction" relationship: has_input_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: part_of UPa:UER00044 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 5/5 relationship: part_of UPa:UER00847 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 1/5 [Term] id: UPa:UCR02362 name: n H(2)O + pectin = n methanol + pectate namespace: reaction xref: KEGG:R02362 "KEGG reaction" xref: METACYC:PECTINESTERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00714 {cardinality="1"} ! pectin relationship: has_output_compound UPa:UPC00132 {cardinality="1"} ! methanol relationship: has_output_compound UPa:UPC00470 {cardinality="1"} ! pectate relationship: part_of UPa:UER00823 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5 [Term] id: UPa:UCR02401 name: 5-oxopentanoate + H(2)O + NAD(+) = H(+) + NADH + glutarate namespace: reaction xref: KEGG:R02401 "KEGG reaction" xref: METACYC:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12067 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03273 {cardinality="1"} ! 5-oxopentanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00489 {cardinality="1"} ! glutarate relationship: part_of UPa:UER00846 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 6/6 [Term] id: UPa:UCR02412 name: ATP + shikimate = 3-phosphoshikimate + ADP namespace: reaction xref: KEGG:R02412 "KEGG reaction" xref: METACYC:SHIKIMATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13124 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate relationship: part_of UPa:UER00088 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7 [Term] id: UPa:UCR02413 name: NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH namespace: reaction xref: KEGG:R02413 "KEGG reaction" xref: METACYC:SHIKIMATE-5-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17740 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00493 {cardinality="1"} ! shikimate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: part_of UPa:UER00087 {cardinality="1", direction="RL", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7 [Term] id: UPa:UCR02422 name: H(2)O + allantoate = (S)-ureidoglycolate + urea namespace: reaction xref: KEGG:R02422 "KEGG reaction" xref: METACYC:ALLANTOICASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11019 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: part_of UPa:UER00654 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1 [Term] id: UPa:UCR02423 name: H(2)O + allantoate = 2-ureidoglycine + CO(2) + NH(3) namespace: reaction xref: KEGG:R02423 "KEGG reaction" xref: METACYC:ALLANTOATE-DEIMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13596 "Rhea reaction" xref: RHEA:27488 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="1"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 [Term] id: UPa:UCR02425 name: (S)-allantoin + H(2)O = allantoate namespace: reaction xref: KEGG:R02425 "KEGG reaction" xref: METACYC:ALLANTOINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17032 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: has_output_compound UPa:UPC00499 {cardinality="1"} ! allantoate relationship: part_of UPa:UER00653 {cardinality="1", direction="LR", order="1"} ! allantoate from (S)-allantoin: step 1/1 [Term] id: UPa:UCR02426 name: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O namespace: reaction xref: KEGG:R02426 "KEGG reaction" xref: METACYC:CDP-GLUCOSE-46-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17156 "Rhea reaction" relationship: has_input_compound UPa:UPC00501 {cardinality="1"} ! CDP-glucose relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00512 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 2/5 [Term] id: UPa:UCR02437 name: L-rhamnose = L-rhamnulose namespace: reaction xref: KEGG:R02437 "KEGG reaction" xref: METACYC:RHAMNISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23163 "Rhea reaction" relationship: has_input_compound UPa:UPC00507 {cardinality="1"} ! L-rhamnose relationship: has_output_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose relationship: part_of UPa:UER00601 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 1/3 [Term] id: UPa:UCR02439 name: ATP + L-ribulose = ADP + L-ribulose 5-phosphate namespace: reaction xref: KEGG:R02439 "KEGG reaction" xref: METACYC:RXN0-5116 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22075 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00508 {cardinality="1"} ! L-ribulose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: part_of UPa:UER00566 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3 [Term] id: UPa:UCR02466 name: 3-sulfino-L-alanine = CO(2) + hypotaurine namespace: reaction xref: KEGG:R02466 "KEGG reaction" xref: METACYC:SULFINOALANINE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16880 "Rhea reaction" relationship: has_input_compound UPa:UPC00606 {cardinality="1"} ! 3-sulfino-L-alanine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UER00538 {cardinality="1", direction="LR", order="1"} ! hypotaurine from L-cysteine: step 2/2 [Term] id: UPa:UCR02467 name: 2-aminoethanethiol + O(2) = hypotaurine namespace: reaction xref: KEGG:R02467 "KEGG reaction" xref: METACYC:CYSTEAMINE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14412 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01678 {cardinality="1"} ! 2-aminoethanethiol relationship: has_output_compound UPa:UPC00519 {cardinality="1"} ! hypotaurine relationship: part_of UPa:UER00536 {cardinality="1", direction="LR", order="1"} ! hypotaurine from 2-aminoethanethiol: step 1/1 [Term] id: UPa:UCR02472 name: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH namespace: reaction xref: KEGG:R02472 "KEGG reaction" xref: METACYC:2-DEHYDROPANTOATE-REDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16236 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00966 {cardinality="1"} ! 2-dehydropantoate relationship: part_of UPa:UER00004 {cardinality="1", direction="RL", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2 [Term] id: UPa:UCR02473 name: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate namespace: reaction xref: KEGG:R02473 "KEGG reaction" xref: METACYC:PANTOATE-BETA-ALANINE-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10915 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00099 {cardinality="1"} ! beta-alanine relationship: has_input_compound UPa:UPC00522 {cardinality="1"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: part_of UPa:UER00005 {cardinality="1", direction="LR", order="1"} ! (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1 [Term] id: UPa:UCR02493 name: ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate namespace: reaction xref: KEGG:R02493 "KEGG reaction" xref: METACYC:PYRAMKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25107 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:UER00299 {cardinality="1", direction="LR", order="1"} ! pyridoxamine 5'-phosphate from pyridoxamine: step 1/1 [Term] id: UPa:UCR02494 name: phosphate + pyridoxamine = H(2)O + pyridoxamine 5'-phosphate namespace: reaction xref: KEGG:R02494 "KEGG reaction" xref: RHEA:25138 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00534 {cardinality="1"} ! pyridoxamine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00647 {cardinality="1"} ! pyridoxamine 5'-phosphate relationship: part_of UPa:UER00302 {cardinality="1", direction="RL", order="1"} ! pyridoxamine from pyridoxamine 5'-phosphate: step 1/1 [Term] id: UPa:UCR02519 name: O(2) + homogentisate = 4-maleylacetoacetate namespace: reaction xref: KEGG:R02519 "KEGG reaction" xref: METACYC:HOMOGENTISATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15452 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00544 {cardinality="1"} ! homogentisate relationship: has_output_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate relationship: part_of UPa:UER00339 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 4/6 [Term] id: UPa:UCR02521 name: (4-hydroxyphenyl)pyruvate + O(2) = CO(2) + homogentisate namespace: reaction xref: KEGG:R02521 "KEGG reaction" xref: METACYC:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16192 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01179 {cardinality="1"} ! (4-hydroxyphenyl)pyruvate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00544 {cardinality="1"} ! homogentisate relationship: part_of UPa:UER00362 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 3/6 [Term] id: UPa:UCR02522 name: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O namespace: reaction xref: KEGG:R02522 "KEGG reaction" xref: METACYC:L-ARABINONATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20971 "Rhea reaction" relationship: has_input_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00684 {cardinality="1"} ! 2-dehydro-3-deoxy-L-arabinonate relationship: part_of UPa:UER00570 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 3/3 [Term] id: UPa:UCR02526 name: H(2)O + L-arabinono-1,4-lactone = L-arabinonate namespace: reaction xref: KEGG:R02526 "KEGG reaction" xref: METACYC:L-ARABINONOLACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16220 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01114 {cardinality="1"} ! L-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00545 {cardinality="1"} ! L-arabinonate relationship: part_of UPa:UER00569 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-L-arabinonate from L-arabinose: step 2/3 [Term] id: UPa:UCR02530 name: (R)-S-lactoylglutathione = glutathione + methylglyoxal namespace: reaction xref: KEGG:R02530 "KEGG reaction" xref: METACYC:GLYOXI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19072 "Rhea reaction" relationship: has_input_compound UPa:UPC03451 {cardinality="1"} ! (R)-S-lactoylglutathione relationship: has_output_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_output_compound UPa:UPC00546 {cardinality="1"} ! methylglyoxal relationship: part_of UPa:UER00675 {cardinality="1", direction="RL", order="1"} ! (R)-lactate from methylglyoxal: step 1/2 [Term] id: UPa:UCR02533 name: (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R02533 "KEGG reaction" xref: METACYC:RXN66-241 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25272 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00788 {cardinality="1"} ! (R)-adrenaline relationship: part_of UPa:UER00736 {cardinality="1", direction="LR", order="1"} ! (R)-adrenaline from (R)-noradrenaline: step 1/1 [Term] id: UPa:UCR02535 name: L-ascorbate + O(2) + dopamine = (R)-noradrenaline + H(2)O + L-dehydroascorbate namespace: reaction xref: KEGG:R02535 "KEGG reaction" xref: METACYC:DOPAMINE-BETA-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19120 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC03758 {cardinality="1"} ! dopamine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00547 {cardinality="1"} ! (R)-noradrenaline relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate relationship: part_of UPa:UER00735 {cardinality="1", direction="LR", order="1"} ! (R)-noradrenaline from dopamine: step 1/1 [Term] id: UPa:UCR02536 name: H(2)O + NAD(+) + phenylacetaldehyde = H(+) + NADH + phenylacetate namespace: reaction xref: KEGG:R02536 "KEGG reaction" xref: METACYC:PHENDEHYD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21395 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC07086 {cardinality="1"} ! phenylacetate relationship: part_of UPa:UER00724 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 3/3 [Term] id: UPa:UCR02545 name: NAD(+) + meso-tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R02545 "KEGG reaction" xref: METACYC:RXN-8643 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16460 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00552 {cardinality="1"} ! meso-tartrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00801 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1 [Term] id: UPa:UCR02549 name: 4-aminobutanal + H(2)O + NAD(+) = 4-aminobutanoate + H(+) + NADH namespace: reaction xref: KEGG:R02549 "KEGG reaction" xref: METACYC:AMINOBUTDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19108 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00555 {cardinality="1"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: part_of UPa:UER00292 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from 4-aminobutanal: step 1/1 [Term] id: UPa:UCR02553 name: NAD(+) + cyclopentanol = H(+) + NADH + cyclopentanone namespace: reaction xref: KEGG:R02553 "KEGG reaction" xref: METACYC:CYCLOPENTANOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11731 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC02020 {cardinality="1"} ! cyclopentanol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone relationship: part_of UPa:UER00749 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 1/2 [Term] id: UPa:UCR02554 name: H(+) + NADPH + O(2) + cyclopentanone = 5-valerolactone + H(2)O + NADP(+) namespace: reaction xref: KEGG:R02554 "KEGG reaction" xref: METACYC:CYCLOPENTANONE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15740 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00557 {cardinality="1"} ! cyclopentanone relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC02240 {cardinality="1"} ! 5-valerolactone relationship: part_of UPa:UER00750 {cardinality="1", direction="LR", order="1"} ! 5-valerolactone from cyclopentanol: step 2/2 [Term] id: UPa:UCR02565 name: H(2)O + NAD(+) + betaine aldehyde = 2 H(+) + NADH + betaine namespace: reaction xref: KEGG:R02565 "KEGG reaction" xref: METACYC:BADH-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15308 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UER00386 {cardinality="1", direction="LR", order="1"} ! betaine from betaine aldehyde: step 1/1 [Term] id: UPa:UCR02571 name: Enzyme N6-(dihydrolipoyl)lysine + glutaryl-CoA = CoA + S(8)-glutaryldihydrolipoamide namespace: reaction xref: KEGG:R02571 "KEGG reaction" relationship: has_input_compound UPa:UPC00527 {cardinality="1"} ! glutaryl-CoA relationship: has_input_compound UPa:UPC15973 {cardinality="1"} ! Enzyme N6-(dihydrolipoyl)lysine relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC06157 {cardinality="1"} ! S(8)-glutaryldihydrolipoamide relationship: part_of UPa:UER00840 {cardinality="1", direction="RL", order="1"} ! glutaryl-CoA from L-lysine: step 6/6 [Term] id: UPa:UCR02601 name: 2-hydroxy-2,4-pentadienoate + H(2)O = 4-hydroxy-2-oxopentanoate namespace: reaction xref: KEGG:R02601 "KEGG reaction" xref: METACYC:2-OXOPENT-4-ENOATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22583 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC03589 {cardinality="1"} ! 4-hydroxy-2-oxopentanoate relationship: part_of UPa:UER00796 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 3/4 relationship: part_of UPa:UER00906 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 6/7 [Term] id: UPa:UCR02603 name: 2-hydroxy-2,4-pentadienoate + succinate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O namespace: reaction xref: KEGG:R02603 "KEGG reaction" xref: METACYC:MHPCHYDROL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24792 "Rhea reaction" relationship: has_input_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_input_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: part_of UPa:UER00795 {cardinality="1", direction="RL", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 2/4 [Term] id: UPa:UCR02606 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(2)O = 2-hydroxy-2,4-pentadienoate + benzoate namespace: reaction xref: KEGG:R02606 "KEGG reaction" xref: METACYC:3.7.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17164 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:UER00253 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4 [Term] id: UPa:UCR02613 name: 2-phenylethylamine + H(2)O + O(2) = H(2)O(2) + NH(3) + phenylacetaldehyde namespace: reaction xref: KEGG:R02613 "KEGG reaction" xref: METACYC:AMINEPHEN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25268 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC05332 {cardinality="1"} ! 2-phenylethylamine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00601 {cardinality="1"} ! phenylacetaldehyde relationship: part_of UPa:UER00723 {cardinality="1", direction="LR", order="1"} ! phenylacetate from L-phenylalanine: step 2/3 [Term] id: UPa:UCR02649 name: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate namespace: reaction xref: KEGG:R02649 "KEGG reaction" xref: METACYC:ACETYLGLUTKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14632 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00624 {cardinality="1"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:UER00107 {cardinality="1", direction="LR", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 2/4 [Term] id: UPa:UCR02664 name: 2-phospho-D-glycerate + ATP = 2,3-bisphospho-D-glycerate + ADP namespace: reaction xref: KEGG:R02664 "KEGG reaction" xref: RHEA:42411 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00631 {cardinality="1"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate relationship: part_of UPa:UER00609 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2 [Term] id: UPa:UCR02665 name: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde namespace: reaction xref: KEGG:R02665 "KEGG reaction" xref: METACYC:1.13.11.6-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17956 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde relationship: part_of UPa:UER00330 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 3/3 [Term] id: UPa:UCR02668 name: 3-hydroxy-L-kynurenine + H(2)O = 3-hydroxyanthranilate + L-alanine namespace: reaction xref: KEGG:R02668 "KEGG reaction" xref: METACYC:3-HYDROXY-KYNURENINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25146 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03227 {cardinality="1"} ! 3-hydroxy-L-kynurenine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00632 {cardinality="1"} ! 3-hydroxyanthranilate relationship: part_of UPa:UER00329 {cardinality="1", direction="LR", order="1"} ! quinolinate from L-kynurenine: step 2/3 [Term] id: UPa:UCR02698 name: 4-hydroxyphenylacetate + H(+) + NADH + O(2) = (3,4-dihydroxyphenyl)acetate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R02698 "KEGG reaction" xref: RHEA:16684 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00642 {cardinality="1"} ! 4-hydroxyphenylacetate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate relationship: part_of UPa:UER00416 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 [Term] id: UPa:UCR02701 name: 5-hydroxy-L-tryptophan = CO(2) + serotonin namespace: reaction xref: KEGG:R02701 "KEGG reaction" xref: METACYC:RXN3DJ-170 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18536 "Rhea reaction" relationship: has_input_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: part_of UPa:UER00814 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 2/2 [Term] id: UPa:UCR02705 name: ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate namespace: reaction xref: KEGG:R02705 "KEGG reaction" xref: METACYC:NANK-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25256 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00645 {cardinality="1"} ! N-acetyl-D-mannosamine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04257 {cardinality="1"} ! N-acetyl-D-mannosamine 6-phosphate relationship: part_of UPa:UER00681 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from N-acetylneuraminate: step 2/5 [Term] id: UPa:UCR02715 name: D-arabinono-1,4-lactone + O(2) = H(2)O(2) + dehydro-D-arabinono-1,4-lactone namespace: reaction xref: KEGG:R02715 "KEGG reaction" xref: METACYC:1.1.3.37-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23759 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00652 {cardinality="1"} ! D-arabinono-1,4-lactone relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC06316 {cardinality="1"} ! dehydro-D-arabinono-1,4-lactone relationship: part_of UPa:UER00766 {cardinality="1", direction="LR", order="1"} ! dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2 [Term] id: UPa:UCR02733 name: H(2)O + N-acetyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + acetate namespace: reaction xref: KEGG:R02733 "KEGG reaction" xref: METACYC:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20408 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: part_of UPa:UER00024 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3 [Term] id: UPa:UCR02734 name: H(2)O + N-succinyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + succinate namespace: reaction xref: KEGG:R02734 "KEGG reaction" xref: METACYC:SUCCDIAMINOPIMDESUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22611 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: part_of UPa:UER00021 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3 [Term] id: UPa:UCR02735 name: LL-2,6-diaminopimelate = DL-2,6-diaminopimelate namespace: reaction xref: KEGG:R02735 "KEGG reaction" xref: METACYC:DIAMINOPIMEPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15396 "Rhea reaction" relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: part_of UPa:UER00025 {cardinality="1", direction="LR", order="1"} ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1 [Term] id: UPa:UCR02749 name: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate namespace: reaction xref: KEGG:R02749 "KEGG reaction" xref: METACYC:D-PPENTOMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25208 "Rhea reaction" xref: RHEA:27661 "Rhea reaction" relationship: has_input_compound UPa:UPC00672 {cardinality="1"} ! 2-deoxy-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC00673 {cardinality="1"} ! 2-deoxy-D-ribose 5-phosphate relationship: part_of UPa:UER00467 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2 [Term] id: UPa:UCR02752 name: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O namespace: reaction xref: KEGG:R02752 "KEGG reaction" xref: METACYC:GLUCARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14576 "Rhea reaction" relationship: has_input_compound UPa:UPC00818 {cardinality="1"} ! D-glucarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:UER00627 {cardinality="1", direction="LR", order="1"} ! 2,5-dioxopentanoate from D-glucarate: step 1/2 [Term] id: UPa:UCR02754 name: 5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate namespace: reaction xref: KEGG:R02754 "KEGG reaction" xref: METACYC:KDGALDOL-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:27729 "Rhea reaction" relationship: has_input_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC01146 {cardinality="1"} ! 2-hydroxy-3-oxopropanoate relationship: part_of UPa:UER00630 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 2/3 [Term] id: UPa:UCR02755 name: DL-2,6-diaminopimelate + H(2)O + NADP(+) = (S)-2-amino-6-oxopimelate + H(+) + NADPH + NH(3) namespace: reaction xref: KEGG:R02755 "KEGG reaction" xref: METACYC:DIAMINOPIMELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13564 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00680 {cardinality="1"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="2"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 [Term] id: UPa:UCR02765 name: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA namespace: reaction xref: KEGG:R02765 "KEGG reaction" xref: METACYC:METHYLMALONYL-COA-EPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20556 "Rhea reaction" relationship: has_input_compound UPa:UPC01213 {cardinality="1"} ! (R)-methylmalonyl-CoA relationship: has_output_compound UPa:UPC00683 {cardinality="1"} ! (S)-methylmalonyl-CoA relationship: part_of UPa:UER00909 {cardinality="1", direction="RL", order="1"} ! succinyl-CoA from propanoyl-CoA: step 2/3 [Term] id: UPa:UCR02782 name: scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O namespace: reaction xref: KEGG:R02782 "KEGG reaction" xref: METACYC:MYO-INOSOSE-2-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14068 "Rhea reaction" relationship: has_input_compound UPa:UPC00691 {cardinality="1"} ! scyllo-inosose relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04287 {cardinality="1"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: part_of UPa:UER00144 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 2/7 [Term] id: UPa:UCR02804 name: H(2)O + dinitrogen + 2 ferricytochrome c = 2 H(+) + 2 ferrocytochrome c + nitrous oxide namespace: reaction xref: KEGG:R02804 "KEGG reaction" xref: METACYC:RXN-12130 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15496 "Rhea reaction" xref: RHEA:43111 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC00697 {cardinality="1"} ! dinitrogen relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC00887 {cardinality="1"} ! nitrous oxide relationship: part_of UPa:UER00709 {cardinality="1", direction="RL", order="1"} ! dinitrogen from nitrate: step 4/4 [Term] id: UPa:UCR02821 name: L-homocysteine + betaine = L-methionine + N,N-dimethylglycine namespace: reaction xref: KEGG:R02821 "KEGG reaction" xref: METACYC:2.1.1.5-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22339 "Rhea reaction" relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: part_of UPa:UER00083 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (BhmT route): step 1/1 relationship: part_of UPa:UER00432 {cardinality="1", direction="LR", order="1"} ! sarcosine from betaine: step 1/2 [Term] id: UPa:UCR02860 name: H(2)O + acceptor + nicotine = (S)-6-hydroxynicotine + reduced acceptor namespace: reaction xref: KEGG:R02860 "KEGG reaction" xref: METACYC:NICOTINE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14772 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine relationship: part_of UPa:UER00487 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 1/2 [Term] id: UPa:UCR02864 name: 2 H(+) + siroheme = Fe2+ + sirohydrochlorin namespace: reaction xref: KEGG:R02864 "KEGG reaction" xref: METACYC:SIROHEME-FERROCHELAT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24363 "Rhea reaction" relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00748 {cardinality="1"} ! siroheme relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC14818 {cardinality="1"} ! Fe2+ relationship: part_of UPa:UER00376 {cardinality="1", direction="RL", order="1"} ! siroheme from sirohydrochlorin: step 1/1 [Term] id: UPa:UCR02869 name: S-adenosylmethioninamine + spermidine = S-methyl-5'-thioadenosine + spermine namespace: reaction xref: KEGG:R02869 "KEGG reaction" xref: METACYC:SPERMINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19976 "Rhea reaction" relationship: has_input_compound UPa:UPC00315 {cardinality="1"} ! spermidine relationship: has_input_compound UPa:UPC01137 {cardinality="1"} ! S-adenosylmethioninamine relationship: has_output_compound UPa:UPC00170 {cardinality="1"} ! S-methyl-5'-thioadenosine relationship: has_output_compound UPa:UPC00750 {cardinality="1"} ! spermine relationship: part_of UPa:UER00315 {cardinality="1", direction="LR", order="1"} ! spermine from spermidine: step 1/1 [Term] id: UPa:UCR02874 name: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+) namespace: reaction xref: KEGG:R02874 "KEGG reaction" xref: METACYC:SQUALENE-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25285 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00751 {cardinality="1"} ! squalene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene relationship: part_of UPa:UER00752 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 2/3 [Term] id: UPa:UCR02911 name: acetyl-CoA + serotonin = CoA + N-acetylserotonin namespace: reaction xref: KEGG:R02911 "KEGG reaction" xref: METACYC:RXN3DJ-35528 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25220 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00780 {cardinality="1"} ! serotonin relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin relationship: part_of UPa:UER00815 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 1/2 [Term] id: UPa:UCR02914 name: 4-imidazolone-5-propanoate = H(2)O + trans-urocanate namespace: reaction xref: KEGG:R02914 "KEGG reaction" xref: METACYC:UROCANATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13104 "Rhea reaction" relationship: has_input_compound UPa:UPC03680 {cardinality="1"} ! 4-imidazolone-5-propanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00785 {cardinality="1"} ! trans-urocanate relationship: part_of UPa:UER00550 {cardinality="1", direction="RL", order="1"} ! N-formimidoyl-L-glutamate from L-histidine: step 2/3 [Term] id: UPa:UCR02922 name: H(2)O + creatinine = N-methylhydantoin + NH(3) namespace: reaction xref: KEGG:R02922 "KEGG reaction" xref: METACYC:CREATININE-DEAMINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12684 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00791 {cardinality="1"} ! creatinine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin relationship: part_of UPa:UER00395 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 1/3 [Term] id: UPa:UCR02933 name: H(2)O + L-gulono-1,4-lactone = L-gulonate namespace: reaction xref: KEGG:R02933 "KEGG reaction" xref: METACYC:RXN-8783 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42519 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC00800 {cardinality="1"} ! L-gulonate relationship: part_of UPa:UER00938 {cardinality="1", direction="RL", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 3/4 [Term] id: UPa:UCR02935 name: (S)-ureidoglycolate + NAD(+) = H(+) + NADH + oxalurate namespace: reaction xref: KEGG:R02935 "KEGG reaction" xref: RHEA:15332 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate relationship: part_of UPa:UER00975 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR02936 name: (S)-ureidoglycolate + NADP(+) = H(+) + NADPH + oxalurate namespace: reaction xref: KEGG:R02936 "KEGG reaction" xref: METACYC:R165-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15336 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00802 {cardinality="1"} ! oxalurate relationship: part_of UPa:UER00976 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR02946 name: (R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH namespace: reaction xref: KEGG:R02946 "KEGG reaction" xref: METACYC:RR-BUTANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24343 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03044 {cardinality="1"} ! (R,R)-butane-2,3-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin relationship: part_of UPa:UER00679 {cardinality="1", direction="RL", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 3/3 [Term] id: UPa:UCR02948 name: (S)-2-acetolactate = (R)-acetoin + CO(2) namespace: reaction xref: KEGG:R02948 "KEGG reaction" xref: METACYC:ACETOLACTATE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21583 "Rhea reaction" relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00810 {cardinality="1"} ! (R)-acetoin relationship: part_of UPa:UER00678 {cardinality="1", direction="LR", order="1"} ! (R,R)-butane-2,3-diol from pyruvate: step 2/3 [Term] id: UPa:UCR02988 name: 3-oxoadipate + NAD(+) = H(+) + NADH + maleylacetate namespace: reaction xref: KEGG:R02988 "KEGG reaction" xref: RHEA:16984 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: part_of UPa:UER00957 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR02989 name: 3-oxoadipate + NADP(+) = H(+) + NADPH + maleylacetate namespace: reaction xref: KEGG:R02989 "KEGG reaction" xref: METACYC:MALEYLACETATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16988 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: part_of UPa:UER00958 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR02990 name: 3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate namespace: reaction xref: KEGG:R02990 "KEGG reaction" xref: METACYC:3-OXOADIPATE-COA-TRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12051 "Rhea reaction" relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC02232 {cardinality="1"} ! 3-oxoadipyl-CoA relationship: part_of UPa:UER00262 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2 [Term] id: UPa:UCR02991 name: 5-oxo-4,5-dihydro-2-furylacetate + H(2)O = 3-oxoadipate namespace: reaction xref: KEGG:R02991 "KEGG reaction" xref: METACYC:3-OXOADIPATE-ENOL-LACTONASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10187 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC00846 {cardinality="1"} ! 3-oxoadipate relationship: part_of UPa:UER00261 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1 [Term] id: UPa:UCR02992 name: 4-pyridoxolactone + H(2)O = 4-pyridoxate namespace: reaction xref: KEGG:R02992 "KEGG reaction" xref: METACYC:4-PYRIDOXOLACTONASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14304 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00971 {cardinality="1"} ! 4-pyridoxolactone relationship: has_output_compound UPa:UPC00847 {cardinality="1"} ! 4-pyridoxate relationship: part_of UPa:UER00589 {cardinality="1", direction="LR", order="1"} ! 4-pyridoxate from pyridoxal: step 2/2 [Term] id: UPa:UCR03005 name: ATP + nicotinate D-ribonucleotide = deamido-NAD(+) + diphosphate namespace: reaction xref: KEGG:R03005 "KEGG reaction" xref: METACYC:NICONUCADENYLYLTRAN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22863 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00857 {cardinality="1"} ! deamido-NAD(+) relationship: part_of UPa:UER00332 {cardinality="1", direction="LR", order="1"} ! deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1 [Term] id: UPa:UCR03013 name: H(2)O + L-histidinol phosphate = L-histidinol + phosphate namespace: reaction xref: KEGG:R03013 "KEGG reaction" xref: METACYC:HISTIDPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14468 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00860 {cardinality="1"} ! L-histidinol relationship: part_of UPa:UER00013 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9 [Term] id: UPa:UCR03014 name: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate namespace: reaction xref: KEGG:R03014 "KEGG reaction" xref: METACYC:RHAMNULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20120 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00861 {cardinality="1"} ! L-rhamnulose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01131 {cardinality="1"} ! L-rhamnulose 1-phosphate relationship: part_of UPa:UER00602 {cardinality="1", direction="LR", order="1"} ! glycerone phosphate from L-rhamnose: step 2/3 [Term] id: UPa:UCR03015 name: H(2)O + N-formylmethanofuran + acceptor = CO(2) + methanofuran + reduced acceptor namespace: reaction xref: KEGG:R03015 "KEGG reaction" xref: METACYC:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19844 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: part_of UPa:UER00692 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3 [Term] id: UPa:UCR03018 name: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP namespace: reaction xref: KEGG:R03018 "KEGG reaction" xref: METACYC:PANTOTHENATE-KIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16376 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00864 {cardinality="1"} ! (R)-pantothenate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate relationship: part_of UPa:UER00352 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 1/5 [Term] id: UPa:UCR03028 name: glutaconyl-1-CoA = CO(2) + crotonoyl-CoA namespace: reaction xref: KEGG:R03028 "KEGG reaction" xref: METACYC:GLUTACONYL-COA-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23975 "Rhea reaction" relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00877 {cardinality="1"} ! crotonoyl-CoA relationship: part_of UPa:UER00688 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 5/5 [Term] id: UPa:UCR03033 name: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O namespace: reaction xref: KEGG:R03033 "KEGG reaction" xref: METACYC:GALACTONDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18652 "Rhea reaction" relationship: has_input_compound UPa:UPC00880 {cardinality="1"} ! D-galactonate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate relationship: part_of UPa:UER00518 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3 [Term] id: UPa:UCR03035 name: ATP + pantotheine 4'-phosphate = 3'-dephospho-CoA + diphosphate namespace: reaction xref: KEGG:R03035 "KEGG reaction" xref: METACYC:PANTEPADENYLYLTRAN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19804 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00882 {cardinality="1"} ! 3'-dephospho-CoA relationship: part_of UPa:UER00355 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 4/5 [Term] id: UPa:UCR03067 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate namespace: reaction xref: KEGG:R03067 "KEGG reaction" xref: METACYC:H2PTEROATESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19952 "Rhea reaction" relationship: has_input_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: has_input_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00921 {cardinality="1"} ! 7,8-dihydropteroate relationship: part_of UPa:UER00156 {cardinality="1", direction="LR", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2 [Term] id: UPa:UCR03069 name: H(2)O + dimethylmaleate = (2R,3S)-2,3-dimethylmalate namespace: reaction xref: KEGG:R03069 "KEGG reaction" xref: METACYC:DIMETHYLMALEATE-HYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20256 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate relationship: has_output_compound UPa:UPC03652 {cardinality="1"} ! (2R,3S)-2,3-dimethylmalate relationship: part_of UPa:UER01018 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 7/8 [Term] id: UPa:UCR03070 name: 2-methylene-3-methylsuccinate = dimethylmaleate namespace: reaction xref: KEGG:R03070 "KEGG reaction" xref: METACYC:METHYLITACONATE-DELTA-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23483 "Rhea reaction" relationship: has_input_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate relationship: has_output_compound UPa:UPC00922 {cardinality="1"} ! dimethylmaleate relationship: part_of UPa:UER01017 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 6/8 [Term] id: UPa:UCR03083 name: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate namespace: reaction xref: KEGG:R03083 "KEGG reaction" xref: METACYC:3-DEHYDROQUINATE-SYNTHASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21971 "Rhea reaction" relationship: has_input_compound UPa:UPC04691 {cardinality="1"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: part_of UPa:UER00085 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7 [Term] id: UPa:UCR03084 name: 3-dehydroquinate = 3-dehydroshikimate + H(2)O namespace: reaction xref: KEGG:R03084 "KEGG reaction" xref: METACYC:3-DEHYDROQUINATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21099 "Rhea reaction" relationship: has_input_compound UPa:UPC00944 {cardinality="1"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02637 {cardinality="1"} ! 3-dehydroshikimate relationship: part_of UPa:UER00086 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7 relationship: part_of UPa:UER00178 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2 [Term] id: UPa:UCR03098 name: ATP + L-alpha-aminoadipate = alpha-aminoadipoyl-C6-AMP + diphosphate namespace: reaction xref: KEGG:R03098 "KEGG reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR03102 name: H(2)O + L-2-aminoadipate 6-semialdahyde + NAD(+) = H(+) + L-alpha-aminoadipate + NADH namespace: reaction xref: KEGG:R03102 "KEGG reaction" xref: METACYC:ALLYSINE-DEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12311 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: part_of UPa:UER00985 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR03103 name: H(2)O + L-2-aminoadipate 6-semialdahyde + NADP(+) = H(+) + L-alpha-aminoadipate + NADPH namespace: reaction xref: KEGG:R03103 "KEGG reaction" xref: METACYC:1.2.1.31-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12307 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: part_of UPa:UER00986 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR03119 name: NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH namespace: reaction xref: KEGG:R03119 "KEGG reaction" xref: METACYC:13-PROPANEDIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23191 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC02457 {cardinality="1"} ! propane-1,3-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00969 {cardinality="1"} ! 3-hydroxypropanal relationship: part_of UPa:UER00671 {cardinality="1", direction="RL", order="1"} ! propane-1,3-diol from glycerol (reductive route): step 2/2 [Term] id: UPa:UCR03130 name: N-acetylserotonin + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + melatonin namespace: reaction xref: KEGG:R03130 "KEGG reaction" xref: METACYC:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15576 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00978 {cardinality="1"} ! N-acetylserotonin relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01598 {cardinality="1"} ! melatonin relationship: part_of UPa:UER00816 {cardinality="1", direction="LR", order="1"} ! melatonin from serotonin: step 2/2 [Term] id: UPa:UCR03163 name: L-fucose = L-fuculose namespace: reaction xref: KEGG:R03163 "KEGG reaction" xref: METACYC:FUCISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17236 "Rhea reaction" relationship: has_input_compound UPa:UPC01019 {cardinality="1"} ! L-fucose relationship: has_output_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose relationship: part_of UPa:UER00624 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3 [Term] id: UPa:UCR03164 name: 6-hydroxynicotinate + reduced ferredoxin = 6-hydroxynicotinate + oxidized ferredoxin namespace: reaction xref: KEGG:R03164 "KEGG reaction" xref: METACYC:6-HYDROXYNICOTINATE-REDUCTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17228 "Rhea reaction" relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC01020 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC04226 {cardinality="1"} ! 6-hydroxynicotinate relationship: part_of UPa:UER01012 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 1/8 [Term] id: UPa:UCR03165 name: hydroxymethylbilane = H(2)O + uroporphyrinogen III namespace: reaction xref: KEGG:R03165 "KEGG reaction" xref: METACYC:UROGENIIISYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18968 "Rhea reaction" relationship: has_input_compound UPa:UPC01024 {cardinality="1"} ! hydroxymethylbilane relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: part_of UPa:UER00320 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 3/4 [Term] id: UPa:UCR03181 name: 4-maleylacetoacetate = 4-fumarylacetoacetate namespace: reaction xref: KEGG:R03181 "KEGG reaction" xref: METACYC:MALEYLACETOACETATE-ISOMERASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14820 "Rhea reaction" relationship: has_input_compound UPa:UPC01036 {cardinality="1"} ! 4-maleylacetoacetate relationship: has_output_compound UPa:UPC01061 {cardinality="1"} ! 4-fumarylacetoacetate relationship: part_of UPa:UER00340 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 5/6 [Term] id: UPa:UCR03182 name: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + phosphate namespace: reaction xref: KEGG:R03182 "KEGG reaction" xref: METACYC:DETHIOBIOTIN-SYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15808 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01909 {cardinality="1"} ! dethiobiotin relationship: part_of UPa:UER00161 {cardinality="1", direction="LR", order="1"} ! biotin from 7,8-diaminononanoate: step 1/2 [Term] id: UPa:UCR03184 name: L-gulono-1,4-lactone + O(2) = H(2)O(2) + L-xylo-hexulonolactone namespace: reaction xref: KEGG:R03184 "KEGG reaction" xref: METACYC:L-GULONOLACTONE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12355 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01040 {cardinality="1"} ! L-gulono-1,4-lactone relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC03289 {cardinality="1"} ! L-xylo-hexulonolactone relationship: part_of UPa:UER00939 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 4/4 [Term] id: UPa:UCR03187 name: ATP + 2 H(2)O + N-methylhydantoin = ADP + N-carbamoylsarcosine + phosphate namespace: reaction xref: KEGG:R03187 "KEGG reaction" xref: METACYC:3.5.2.14-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11723 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC02565 {cardinality="1"} ! N-methylhydantoin relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01043 {cardinality="1"} ! N-carbamoylsarcosine relationship: part_of UPa:UER00396 {cardinality="1", direction="LR", order="1"} ! sarcosine from creatinine: step 2/3 [Term] id: UPa:UCR03194 name: 2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 namespace: reaction xref: KEGG:R03194 "KEGG reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: part_of UPa:UER00211 {cardinality="1", direction="LR", order="1"} ! precorrin-2 from uroporphyrinogen III: step 1/1 [Term] id: UPa:UCR03197 name: uroporphyrinogen III = 4 CO(2) + coproporphyrinogen-III namespace: reaction xref: KEGG:R03197 "KEGG reaction" xref: METACYC:UROGENDECARBOX-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19868 "Rhea reaction" relationship: has_input_compound UPa:UPC01051 {cardinality="1"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: part_of UPa:UER00321 {cardinality="1", direction="LR", order="1"} ! coproporphyrinogen-III from 5-aminolevulinate: step 4/4 [Term] id: UPa:UCR03199 name: (S)-2,3-epoxysqualene = lanosterol namespace: reaction xref: KEGG:R03199 "KEGG reaction" xref: METACYC:LANOSTEROL-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14624 "Rhea reaction" relationship: has_input_compound UPa:UPC01054 {cardinality="1"} ! (S)-2,3-epoxysqualene relationship: has_output_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: part_of UPa:UER00753 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 3/3 [Term] id: UPa:UCR03202 name: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2) namespace: reaction xref: KEGG:R03202 "KEGG reaction" xref: METACYC:S-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11883 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01056 {cardinality="1"} ! (S)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UER00919 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (S-isomer route): step 2/2 [Term] id: UPa:UCR03209 name: ATP + CoA + pimelate = AMP + diphosphate + pimeloyl-CoA namespace: reaction xref: KEGG:R03209 "KEGG reaction" xref: METACYC:6-CARBOXYHEXANOATE--COA-LIGASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14784 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC02656 {cardinality="1"} ! pimelate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: part_of UPa:UER00351 {cardinality="1", direction="LR", order="1"} ! pimeloyl-CoA from pimelate: step 1/1 [Term] id: UPa:UCR03210 name: L-alanine + pimeloyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA namespace: reaction xref: KEGG:R03210 "KEGG reaction" xref: METACYC:7KAPSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20715 "Rhea reaction" xref: RHEA:42291 "Rhea reaction" relationship: has_input_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_input_compound UPa:UPC01063 {cardinality="1"} ! pimeloyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: part_of UPa:UER00159 {cardinality="1", direction="LR", order="1"} ! 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1 [Term] id: UPa:UCR03217 name: L-cysteine + O-acetyl-L-homoserine = L-cystathionine + acetate namespace: reaction xref: KEGG:R03217 "KEGG reaction" xref: METACYC:RXN-721 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:30934 "Rhea reaction" relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC01077 {cardinality="1"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: part_of UPa:UER00448 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-acetyl-L-homoserine: step 1/1 [Term] id: UPa:UCR03220 name: O(2) + coproporphyrinogen-III = 2 CO(2) + 2 H(2)O + protoporphyrinogen-IX namespace: reaction xref: KEGG:R03220 "KEGG reaction" xref: METACYC:RXN0-1461 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18260 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: part_of UPa:UER00322 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1 [Term] id: UPa:UCR03222 name: 3 O(2) + protoporphyrinogen-IX = 3 H(2)O(2) + protoporphyrin-IX namespace: reaction xref: KEGG:R03222 "KEGG reaction" xref: METACYC:PROTOPORGENOXI-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25579 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC02191 {cardinality="1"} ! protoporphyrin-IX relationship: part_of UPa:UER00324 {cardinality="1", direction="LR", order="1"} ! protoporphyrin-IX from protoporphyrinogen-IX: step 1/1 [Term] id: UPa:UCR03223 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole = diphosphate + thiamine phosphate namespace: reaction xref: KEGG:R03223 "KEGG reaction" xref: METACYC:THI-P-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22331 "Rhea reaction" relationship: has_input_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1"} ! thiamine phosphate relationship: part_of UPa:UER00141 {cardinality="1", direction="LR", order="1"} ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1 [Term] id: UPa:UCR03230 name: acetyl-CoA + deacetylvindoline = CoA + vindoline namespace: reaction xref: KEGG:R03230 "KEGG reaction" xref: METACYC:2.3.1.107-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24499 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC01626 {cardinality="1"} ! vindoline relationship: part_of UPa:UER00526 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 6/6 [Term] id: UPa:UCR03231 name: 8-amino-7-oxononanoate + S-adenosyl-L-methionine = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoic acid namespace: reaction xref: KEGG:R03231 "KEGG reaction" xref: METACYC:DAPASYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16864 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04425 {cardinality="1"} ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: part_of UPa:UER00160 {cardinality="1", direction="LR", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1 [Term] id: UPa:UCR03236 name: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate namespace: reaction xref: KEGG:R03236 "KEGG reaction" xref: METACYC:TAGAKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12423 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC03785 {cardinality="1"} ! D-tagatose 1,6-bisphosphate relationship: part_of UPa:UER00715 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2 [Term] id: UPa:UCR03240 name: D-galactose 6-phosphate = D-tagatose 6-phosphate namespace: reaction xref: KEGG:R03240 "KEGG reaction" xref: METACYC:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13036 "Rhea reaction" relationship: has_input_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: has_output_compound UPa:UPC01097 {cardinality="1"} ! D-tagatose 6-phosphate relationship: part_of UPa:UER00714 {cardinality="1", direction="LR", order="1"} ! D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1 [Term] id: UPa:UCR03241 name: ATP + L-fuculose = ADP + L-fuculose 1-phosphate namespace: reaction xref: KEGG:R03241 "KEGG reaction" xref: METACYC:FUCULOKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12379 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01721 {cardinality="1"} ! L-fuculose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01099 {cardinality="1"} ! L-fuculose 1-phosphate relationship: part_of UPa:UER00625 {cardinality="1", direction="LR", order="1"} ! L-lactaldehyde and glycerone phosphate from L-fucose: step 2/3 [Term] id: UPa:UCR03243 name: 2-oxoglutarate + L-histidinol phosphate = L-glutamate + imidazole-acetol phosphate namespace: reaction xref: KEGG:R03243 "KEGG reaction" xref: METACYC:HISTAMINOTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23747 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC01100 {cardinality="1"} ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate relationship: part_of UPa:UER00012 {cardinality="1", direction="RL", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9 [Term] id: UPa:UCR03244 name: L-ribulose 5-phosphate = L-xylulose 5-phosphate namespace: reaction xref: KEGG:R03244 "KEGG reaction" xref: METACYC:LXULRU5P-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18500 "Rhea reaction" relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate relationship: part_of UPa:UER00379 {cardinality="1", direction="RL", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 3/4 [Term] id: UPa:UCR03245 name: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP namespace: reaction xref: KEGG:R03245 "KEGG reaction" xref: METACYC:PHOSPHOMEVALONATE-KINASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16344 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01107 {cardinality="1"} ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01143 {cardinality="1"} ! (R)-5-diphosphomevalonate relationship: part_of UPa:UER00099 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from (R)-mevalonate: step 2/3 [Term] id: UPa:UCR03254 name: 8-phospho-3-deoxy-D-manno-octulosonate + phosphate = D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate namespace: reaction xref: KEGG:R03254 "KEGG reaction" xref: METACYC:KDO-8PSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14056 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC01112 {cardinality="1"} ! D-arabinose 5-phosphate relationship: part_of UPa:UER00474 {cardinality="1", direction="RL", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3 [Term] id: UPa:UCR03256 name: H(2)O + lactose 6-phosphate = D-galactose 6-phosphate + beta-D-glucose namespace: reaction xref: KEGG:R03256 "KEGG reaction" xref: METACYC:LACTOSE6P-HYDROXY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42407 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: has_output_compound UPa:UPC00221 {cardinality="1"} ! beta-D-glucose relationship: has_output_compound UPa:UPC01113 {cardinality="1"} ! D-galactose 6-phosphate relationship: part_of UPa:UER00605 {cardinality="1", direction="LR", order="1"} ! D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1 [Term] id: UPa:UCR03260 name: L-cysteine + O-succinyl-L-homoserine = L-cystathionine + succinate namespace: reaction xref: KEGG:R03260 "KEGG reaction" xref: METACYC:O-SUCCHOMOSERLYASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20400 "Rhea reaction" relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC01118 {cardinality="1"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC02291 {cardinality="1"} ! L-cystathionine relationship: part_of UPa:UER00077 {cardinality="1", direction="LR", order="1"} ! L-cystathionine from O-succinyl-L-homoserine: step 1/1 [Term] id: UPa:UCR03269 name: N-[(R)-4-phosphonopantothenoyl]-L-cysteine = CO(2) + pantotheine 4'-phosphate namespace: reaction xref: KEGG:R03269 "KEGG reaction" xref: METACYC:P-PANTOCYSDECARB-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16796 "Rhea reaction" relationship: has_input_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC01134 {cardinality="1"} ! pantotheine 4'-phosphate relationship: part_of UPa:UER00354 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 3/5 [Term] id: UPa:UCR03298 name: 2,3-bisphospho-D-glycerate + ATP = ADP + cyclic 2,3-diphosphoglycerate + phosphate namespace: reaction xref: KEGG:R03298 "KEGG reaction" xref: RHEA:42415 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01159 {cardinality="1"} ! 2,3-bisphospho-D-glycerate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06189 {cardinality="1"} ! cyclic 2,3-diphosphoglycerate relationship: part_of UPa:UER00610 {cardinality="1", direction="LR", order="1"} ! cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 2/2 [Term] id: UPa:UCR03303 name: (3,4-dihydroxyphenyl)acetate + O(2) = 5-carboxymethyl-2-hydroxymuconate semialdehyde namespace: reaction xref: KEGG:R03303 "KEGG reaction" xref: METACYC:1.13.11.15-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15636 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC01161 {cardinality="1"} ! (3,4-dihydroxyphenyl)acetate relationship: has_output_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: part_of UPa:UER00417 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7 [Term] id: UPa:UCR03307 name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R03307 "KEGG reaction" xref: METACYC:5.5.1.2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23659 "Rhea reaction" relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00265 {cardinality="1", direction="RL", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 [Term] id: UPa:UCR03308 name: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate namespace: reaction xref: KEGG:R03308 "KEGG reaction" xref: METACYC:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14980 "Rhea reaction" relationship: has_input_compound UPa:UPC04553 {cardinality="1"} ! 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC01163 {cardinality="1"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:UER00308 {cardinality="1", direction="LR", order="1"} ! 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate: step 1/1 [Term] id: UPa:UCR03313 name: L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH namespace: reaction xref: KEGG:R03313 "KEGG reaction" xref: METACYC:GLUTSEMIALDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19544 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03287 {cardinality="1"} ! L-glutamyl 5-phosphate relationship: part_of UPa:UER00360 {cardinality="1", direction="RL", order="1"} ! L-glutamate 5-semialdehyde from L-glutamate: step 2/2 [Term] id: UPa:UCR03314 name: L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylic acid + H(2)O namespace: reaction xref: KEGG:R03314 "KEGG reaction" xref: METACYC:SPONTPRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:28237 "Rhea reaction" relationship: has_input_compound UPa:UPC01165 {cardinality="1"} ! L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC03912 {cardinality="1"} ! (S)-1-pyrroline-5-carboxylic acid relationship: part_of UPa:UER00361 {cardinality="1", direction="LR", order="1"} ! L-proline from L-glutamate 5-semialdehyde: step 1/1 [Term] id: UPa:UCR03348 name: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + quinolinate namespace: reaction xref: KEGG:R03348 "KEGG reaction" xref: METACYC:QUINOPRIBOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12736 "Rhea reaction" relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: part_of UPa:UER00331 {cardinality="1", direction="RL", order="1"} ! nicotinate D-ribonucleotide from quinolinate: step 1/1 [Term] id: UPa:UCR03350 name: 8-phospho-3-deoxy-D-manno-octulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate namespace: reaction xref: KEGG:R03350 "KEGG reaction" xref: METACYC:KDO-8PPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11503 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04478 {cardinality="1"} ! 8-phospho-3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: part_of UPa:UER00475 {cardinality="1", direction="LR", order="1"} ! 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 3/3 [Term] id: UPa:UCR03351 name: 3-deoxy-D-manno-octulosonate + CTP = CMP-3-deoxy-D-manno-octulosonate + diphosphate namespace: reaction xref: KEGG:R03351 "KEGG reaction" xref: METACYC:CPM-KDOSYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23451 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC01187 {cardinality="1"} ! 3-deoxy-D-manno-octulosonate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: part_of UPa:UER00476 {cardinality="1", direction="LR", order="1"} ! CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1 [Term] id: UPa:UCR03387 name: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonic acid + ADP namespace: reaction xref: KEGG:R03387 "KEGG reaction" xref: METACYC:DEHYDDEOXGALACTKIN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16528 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01216 {cardinality="1"} ! 2-dehydro-3-deoxy-D-galactonate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC01286 {cardinality="1"} ! 6-phospho-2-dehydro-3-deoxy-D-galactonic acid relationship: part_of UPa:UER00519 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3 [Term] id: UPa:UCR03390 name: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran namespace: reaction xref: KEGG:R03390 "KEGG reaction" xref: METACYC:2.3.1.101-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18064 "Rhea reaction" relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_input_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00693 {cardinality="1", direction="LR", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3 relationship: part_of UPa:UER00704 {cardinality="1", direction="RL", order="1"} ! formate from formaldehyde (H(4)MPT route): step 4/5 [Term] id: UPa:UCR03391 name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NAD(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADH namespace: reaction xref: KEGG:R03391 "KEGG reaction" xref: RHEA:19656 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00967 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR03392 name: CDP-4-dehydro-3,6-dideoxy-D-glucose + H(2)O + NADP(+) = CDP-4-dehydro-6-deoxy-D-glucose + H(+) + NADPH namespace: reaction xref: KEGG:R03392 "KEGG reaction" xref: METACYC:1.17.1.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19660 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01219 {cardinality="1"} ! CDP-4-dehydro-6-deoxy-D-glucose relationship: part_of UPa:UER00968 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR03409 name: H(2)O + guanosine 3'-diphosphate 5'-triphosphate = phosphate + ppGpp namespace: reaction xref: KEGG:R03409 "KEGG reaction" xref: METACYC:PPPGPPHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13076 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04494 {cardinality="1"} ! guanosine 3'-diphosphate 5'-triphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01228 {cardinality="1"} ! ppGpp relationship: part_of UPa:UER00885 {cardinality="1", direction="LR", order="1"} ! ppGpp from GTP: step 2/2 [Term] id: UPa:UCR03418 name: 1-alpha-D-galactosyl-myo-inositol + raffinose = myo-inositol + stachyose namespace: reaction xref: KEGG:R03418 "KEGG reaction" xref: METACYC:2.4.1.67-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20779 "Rhea reaction" relationship: has_input_compound UPa:UPC00492 {cardinality="1"} ! raffinose relationship: has_input_compound UPa:UPC01235 {cardinality="1"} ! 1-alpha-D-galactosyl-myo-inositol relationship: has_output_compound UPa:UPC00137 {cardinality="1"} ! myo-inositol relationship: has_output_compound UPa:UPC01613 {cardinality="1"} ! stachyose relationship: part_of UPa:UER00892 {cardinality="1", direction="LR", order="1"} ! stachyose from raffinose: step 1/1 [Term] id: UPa:UCR03443 name: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH namespace: reaction xref: KEGG:R03443 "KEGG reaction" xref: METACYC:N-ACETYLGLUTPREDUCT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21591 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC01250 {cardinality="1"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04133 {cardinality="1"} ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:UER00108 {cardinality="1", direction="RL", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate: step 3/4 [Term] id: UPa:UCR03444 name: (R)-homocitrate = H(2)O + homo-cis-aconitate namespace: reaction xref: KEGG:R03444 "KEGG reaction" xref: METACYC:RXN3O-1983 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26104 "Rhea reaction" relationship: has_input_compound UPa:UPC01251 {cardinality="1"} ! (R)-homocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate relationship: part_of UPa:UER00029 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 2/5 [Term] id: UPa:UCR03445 name: 4-(2-aminophenyl)-2,4-dioxobutanoate = H(2)O + kynurenate namespace: reaction xref: KEGG:R03445 "KEGG reaction" xref: METACYC:RXN-10720 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42455 "Rhea reaction" relationship: has_input_compound UPa:UPC01252 {cardinality="1"} ! 4-(2-aminophenyl)-2,4-dioxobutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01717 {cardinality="1"} ! kynurenate relationship: part_of UPa:UER00727 {cardinality="1", direction="LR", order="1"} ! kynurenate from L-kynurenine: step 2/2 [Term] id: UPa:UCR03457 name: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = H(2)O + imidazole-acetol phosphate namespace: reaction xref: KEGG:R03457 "KEGG reaction" xref: METACYC:IMIDPHOSDEHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11043 "Rhea reaction" relationship: has_input_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01267 {cardinality="1"} ! imidazole-acetol phosphate relationship: part_of UPa:UER00011 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9 [Term] id: UPa:UCR03458 name: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH namespace: reaction xref: KEGG:R03458 "KEGG reaction" xref: METACYC:RIBOFLAVINSYNREDUC-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17848 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: part_of UPa:UER00402 {cardinality="1", direction="RL", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4 [Term] id: UPa:UCR03459 name: 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3) namespace: reaction xref: KEGG:R03459 "KEGG reaction" xref: METACYC:RIBOFLAVINSYNDEAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21871 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01304 {cardinality="1"} ! 2,5-diamino-4-hydroxy-6-(5-phosphoribosylamino)pyrimidine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC01268 {cardinality="1"} ! 5-amino-6-(5-phosphoribosylamino)uracil relationship: part_of UPa:UER00401 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4 [Term] id: UPa:UCR03460 name: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate namespace: reaction xref: KEGG:R03460 "KEGG reaction" xref: METACYC:2.5.1.19-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21259 "Rhea reaction" relationship: has_input_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC03175 {cardinality="1"} ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01269 {cardinality="1"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: part_of UPa:UER00089 {cardinality="1", direction="LR", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7 [Term] id: UPa:UCR03462 name: O(2) + biphenyl-2,3-diol = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate namespace: reaction xref: KEGG:R03462 "KEGG reaction" xref: METACYC:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14416 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC01273 {cardinality="1"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: part_of UPa:UER00252 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4 [Term] id: UPa:UCR03464 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin namespace: reaction xref: KEGG:R03464 "KEGG reaction" xref: METACYC:3.5.4.27-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19056 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01274 {cardinality="1"} ! N(5)-formyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00694 {cardinality="1", direction="RL", order="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3 relationship: part_of UPa:UER00703 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 3/5 [Term] id: UPa:UCR03470 name: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 5-oxo-4,5-dihydro-2-furylacetate + CO(2) namespace: reaction xref: KEGG:R03470 "KEGG reaction" xref: METACYC:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23351 "Rhea reaction" relationship: has_input_compound UPa:UPC01278 {cardinality="1"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UER00266 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2 [Term] id: UPa:UCR03471 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP namespace: reaction xref: KEGG:R03471 "KEGG reaction" xref: METACYC:OHMETPYRKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23099 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: part_of UPa:UER00137 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3 [Term] id: UPa:UCR03503 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + AMP namespace: reaction xref: KEGG:R03503 "KEGG reaction" xref: METACYC:H2PTERIDINEPYROPHOSPHOKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11415 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC04807 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: part_of UPa:UER00155 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 [Term] id: UPa:UCR03504 name: 7,8-dihydroneopterin = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde namespace: reaction xref: KEGG:R03504 "KEGG reaction" xref: METACYC:H2NEOPTERINALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10543 "Rhea reaction" relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00266 {cardinality="1"} ! glycolaldehyde relationship: has_output_compound UPa:UPC01300 {cardinality="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: part_of UPa:UER00154 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4 [Term] id: UPa:UCR03508 name: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = CO(2) + H(2)O + indoleglycerol phosphate namespace: reaction xref: KEGG:R03508 "KEGG reaction" xref: METACYC:IGPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23479 "Rhea reaction" relationship: has_input_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03506 {cardinality="1"} ! indoleglycerol phosphate relationship: part_of UPa:UER00043 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 4/5 [Term] id: UPa:UCR03509 name: N-(5-phospho-beta-D-ribosyl)anthranilic acid = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate namespace: reaction xref: KEGG:R03509 "KEGG reaction" xref: METACYC:PRAISOM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21543 "Rhea reaction" relationship: has_input_compound UPa:UPC04302 {cardinality="1"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC01302 {cardinality="1"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: part_of UPa:UER00042 {cardinality="1", direction="LR", order="1"} ! L-tryptophan from chorismate: step 3/5 [Term] id: UPa:UCR03534 name: 2-hydroxyglutarate + FAD = 2-oxoglutarate + FADH2 namespace: reaction xref: KEGG:R03534 "KEGG reaction" xref: METACYC:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:21255 "Rhea reaction" xref: RHEA:25264 "Rhea reaction" relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: part_of UPa:UER00685 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 2/5 [Term] id: UPa:UCR03543 name: H(+) + NADH + O(2) + benzene = NAD(+) + cis-1,2-dihydrobenzene-1,2-diol namespace: reaction xref: KEGG:R03543 "KEGG reaction" xref: METACYC:BENZENE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13816 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01407 {cardinality="1"} ! benzene relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC04091 {cardinality="1"} ! cis-1,2-dihydrobenzene-1,2-diol relationship: part_of UPa:UER00391 {cardinality="1", direction="LR", order="1"} ! catechol from benzene: step 1/2 [Term] id: UPa:UCR03559 name: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) namespace: reaction xref: KEGG:R03559 "KEGG reaction" xref: METACYC:TOLUENE-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16740 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01455 {cardinality="1"} ! toluene relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:UER00393 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 1/2 [Term] id: UPa:UCR03630 name: H(+) + NADH + O(2) + phthalate = NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid namespace: reaction xref: KEGG:R03630 "KEGG reaction" xref: METACYC:PHTHALATE-45-DIOXYGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17492 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01606 {cardinality="1"} ! phthalate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: part_of UPa:UER00728 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 1/3 [Term] id: UPa:UCR03693 name: L-citramalate = H(2)O + mesaconate namespace: reaction xref: KEGG:R03693 "KEGG reaction" xref: METACYC:S-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13532 "Rhea reaction" relationship: has_input_compound UPa:UPC02614 {cardinality="1"} ! L-citramalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate relationship: part_of UPa:UER00619 {cardinality="1", direction="RL", order="1"} ! acetate and pyruvate from L-glutamate: step 3/4 [Term] id: UPa:UCR03696 name: (2S,3S)-3-methyl-L-aspartate = NH(3) + mesaconate namespace: reaction xref: KEGG:R03696 "KEGG reaction" xref: METACYC:METHYLASPARTATE-AMMONIA-LYASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12832 "Rhea reaction" relationship: has_input_compound UPa:UPC03618 {cardinality="1"} ! (2S,3S)-3-methyl-L-aspartate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC01732 {cardinality="1"} ! mesaconate relationship: part_of UPa:UER00618 {cardinality="1", direction="LR", order="1"} ! acetate and pyruvate from L-glutamate: step 2/4 [Term] id: UPa:UCR03721 name: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine namespace: reaction xref: KEGG:R03721 "KEGG reaction" xref: METACYC:2.1.1.118-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15376 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01795 {cardinality="1"} ! columbamine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05315 {cardinality="1"} ! palmatine relationship: part_of UPa:UER00445 {cardinality="1", direction="LR", order="1"} ! palmatine from columbamine: step 1/1 [Term] id: UPa:UCR03738 name: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine namespace: reaction xref: KEGG:R03738 "KEGG reaction" xref: METACYC:STRICTOSIDINE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15016 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03470 {cardinality="1"} ! 3alpha(S)-strictosidine relationship: has_output_compound UPa:UPC00398 {cardinality="1"} ! tryptamine relationship: has_output_compound UPa:UPC01852 {cardinality="1"} ! secologanin relationship: part_of UPa:UER00447 {cardinality="1", direction="RL", order="1"} ! 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1 [Term] id: UPa:UCR03791 name: (S)-mandelate = (R)-mandelate namespace: reaction xref: KEGG:R03791 "KEGG reaction" xref: METACYC:MANDELATE-RACEMASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13948 "Rhea reaction" relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate relationship: has_output_compound UPa:UPC01983 {cardinality="1"} ! (R)-mandelate relationship: part_of UPa:UER00852 {cardinality="1", direction="RL", order="1"} ! benzoate from (R)-mandelate: step 1/4 [Term] id: UPa:UCR03793 name: (S)-mandelate + acceptor = phenylglyoxylate + reduced acceptor namespace: reaction xref: KEGG:R03793 "KEGG reaction" xref: METACYC:MANDELATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15752 "Rhea reaction" relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC01984 {cardinality="1"} ! (S)-mandelate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC02137 {cardinality="1"} ! phenylglyoxylate relationship: part_of UPa:UER00853 {cardinality="1", direction="LR", order="1"} ! benzoate from (R)-mandelate: step 2/4 [Term] id: UPa:UCR03831 name: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) namespace: reaction xref: KEGG:R03831 "KEGG reaction" xref: METACYC:RETICULINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19888 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC02106 {cardinality="1"} ! (S)-scoulerine relationship: part_of UPa:UER00450 {cardinality="1", direction="LR", order="1"} ! (S)-scoulerine from (S)-reticuline: step 1/1 [Term] id: UPa:UCR03832 name: (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R03832 "KEGG reaction" xref: METACYC:2.1.1.116-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17792 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02105 {cardinality="1"} ! (S)-reticuline relationship: part_of UPa:UER00444 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 4/4 [Term] id: UPa:UCR03892 name: maleylacetate = 3-hydroxy-cis,cis-muconate namespace: reaction xref: KEGG:R03892 "KEGG reaction" xref: METACYC:RXN-9922 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42435 "Rhea reaction" relationship: has_input_compound UPa:UPC02222 {cardinality="1"} ! maleylacetate relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:UER00269 {cardinality="1", direction="RL", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4 [Term] id: UPa:UCR03896 name: (R)-citramalate = 2-methylmaleate + H(2)O namespace: reaction xref: KEGG:R03896 "KEGG reaction" xref: METACYC:R-2-METHYLMALATE-DEHYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22335 "Rhea reaction" relationship: has_input_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 2/3 [Term] id: UPa:UCR03898 name: 2-methylmaleate + H(2)O = D-erythro-3-methylmalic acid namespace: reaction xref: KEGG:R03898 "KEGG reaction" xref: RHEA:42427 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02226 {cardinality="1"} ! 2-methylmaleate relationship: has_output_compound UPa:UPC06032 {cardinality="1"} ! D-erythro-3-methylmalic acid relationship: part_of UPa:UER00067 {cardinality="1", direction="LR", order="2"} ! 2-oxobutanoate from pyruvate: step 2/3 [Term] id: UPa:UCR03908 name: 2-methyleneglutarate = 2-methylene-3-methylsuccinate namespace: reaction xref: KEGG:R03908 "KEGG reaction" xref: METACYC:2-METHYLENEGLUTARATE-MUTASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13796 "Rhea reaction" relationship: has_input_compound UPa:UPC02930 {cardinality="1"} ! 2-methyleneglutarate relationship: has_output_compound UPa:UPC02295 {cardinality="1"} ! 2-methylene-3-methylsuccinate relationship: part_of UPa:UER01016 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 5/8 [Term] id: UPa:UCR03932 name: 4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R03932 "KEGG reaction" xref: METACYC:6.2.1.33-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23223 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC02370 {cardinality="1"} ! 4-chlorobenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA relationship: part_of UPa:UER01020 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 1/3 [Term] id: UPa:UCR03937 name: H(2)O + glutaconyl-1-CoA = 2-hydroxyglutaryl-CoA namespace: reaction xref: KEGG:R03937 "KEGG reaction" xref: METACYC:RXN-1083 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42451 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02411 {cardinality="1"} ! glutaconyl-1-CoA relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA relationship: part_of UPa:UER00687 {cardinality="1", direction="RL", order="1"} ! crotonoyl-CoA from L-glutamate: step 4/5 [Term] id: UPa:UCR03947 name: NAD(+) + precorrin-2 = H(+) + NADH + sirohydrochlorin namespace: reaction xref: KEGG:R03947 "KEGG reaction" xref: METACYC:DIMETHUROPORDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15616 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: part_of UPa:UER00222 {cardinality="1", direction="LR", order="1"} ! sirohydrochlorin from precorrin-2: step 1/1 [Term] id: UPa:UCR03948 name: S-adenosyl-L-methionine + precorrin-2 = H(+) + S-adenosyl-L-homocysteine + precorrin-3A namespace: reaction xref: KEGG:R03948 "KEGG reaction" xref: METACYC:2.1.1.130-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16844 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC02463 {cardinality="1"} ! precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A relationship: part_of UPa:UER00212 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10 [Term] id: UPa:UCR03968 name: (2S)-2-isopropylmalate = 2-isopropylmaleate + H(2)O namespace: reaction xref: KEGG:R03968 "KEGG reaction" xref: METACYC:3-ISOPROPYLMALISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16296 "Rhea reaction" relationship: has_input_compound UPa:UPC02504 {cardinality="1"} ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate relationship: part_of UPa:UER00071 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 [Term] id: UPa:UCR04000 name: 2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate namespace: reaction xref: KEGG:R04000 "KEGG reaction" xref: METACYC:RXN-1082 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42079 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC02630 {cardinality="1"} ! 2-hydroxyglutarate relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC03058 {cardinality="1"} ! 2-hydroxyglutaryl-CoA relationship: part_of UPa:UER00686 {cardinality="1", direction="LR", order="1"} ! crotonoyl-CoA from L-glutamate: step 3/5 [Term] id: UPa:UCR04001 name: (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H(2)O namespace: reaction xref: KEGG:R04001 "KEGG reaction" xref: METACYC:RXN-8991 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10679 "Rhea reaction" relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02631 {cardinality="1"} ! 2-isopropylmaleate relationship: part_of UPa:UER00071 {cardinality="1", direction="RL", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate: step 2/4 [Term] id: UPa:UCR04013 name: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + desacetoxyvindoline namespace: reaction xref: KEGG:R04013 "KEGG reaction" xref: METACYC:2.1.1.99-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11339 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline relationship: part_of UPa:UER00524 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 4/6 [Term] id: UPa:UCR04029 name: 2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate namespace: reaction xref: KEGG:R04029 "KEGG reaction" xref: METACYC:ACETCAPR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42507 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02727 {cardinality="1"} ! N(6)-acetyl-L-lysine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate relationship: part_of UPa:UER00842 {cardinality="1", direction="LR", order="1"} ! glutarate from L-lysine: step 2/6 [Term] id: UPa:UCR04030 name: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate namespace: reaction xref: KEGG:R04030 "KEGG reaction" xref: METACYC:O-SUCCINYLBENZOATE-COA-LIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17012 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA relationship: part_of UPa:UER00166 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7 [Term] id: UPa:UCR04031 name: 2-succinylbenzoate + H(2)O = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid namespace: reaction xref: KEGG:R04031 "KEGG reaction" xref: METACYC:O-SUCCINYLBENZOATE-COA-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10199 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02730 {cardinality="1"} ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC05817 {cardinality="1"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: part_of UPa:UER00165 {cardinality="1", direction="RL", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7 [Term] id: UPa:UCR04035 name: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-5'-AMP + diphosphate namespace: reaction xref: KEGG:R04035 "KEGG reaction" xref: METACYC:HISTPRATPHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22831 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02739 {cardinality="1"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: part_of UPa:UER00007 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 [Term] id: UPa:UCR04037 name: 1-(5-phosphoribosyl)-5'-AMP + H(2)O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide namespace: reaction xref: KEGG:R04037 "KEGG reaction" xref: METACYC:HISTCYCLOHYD-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20052 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02741 {cardinality="1"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: part_of UPa:UER00008 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9 [Term] id: UPa:UCR04061 name: O(2) + benzene-1,2,4-triol = 3-hydroxy-cis,cis-muconate namespace: reaction xref: KEGG:R04061 "KEGG reaction" xref: METACYC:RXN-10137 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19444 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC02814 {cardinality="1"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC03676 {cardinality="1"} ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:UER00268 {cardinality="1", direction="LR", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4 [Term] id: UPa:UCR04088 name: (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH namespace: reaction xref: KEGG:R04088 "KEGG reaction" xref: METACYC:TOLUENE-DIOL-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25196 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04592 {cardinality="1"} ! (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02923 {cardinality="1"} ! 3-methylcatechol relationship: part_of UPa:UER00394 {cardinality="1", direction="LR", order="1"} ! 3-methylcatechol from toluene: step 2/2 [Term] id: UPa:UCR04095 name: 3-isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2 namespace: reaction xref: KEGG:R04095 "KEGG reaction" xref: METACYC:RXN-14264 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31066 "Rhea reaction" relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC02939 {cardinality="1"} ! 3-isovaleryl-CoA relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: has_output_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA relationship: part_of UPa:UER00860 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3 [Term] id: UPa:UCR04101 name: 4-chlorobenzoyl-CoA + H(2)O = 4-hydroxybenzoyl-CoA + H(+) + chloride namespace: reaction xref: KEGG:R04101 "KEGG reaction" xref: METACYC:3.8.1.7-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14856 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06387 {cardinality="1"} ! 4-chlorobenzoyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00698 {cardinality="1"} ! chloride relationship: has_output_compound UPa:UPC02949 {cardinality="1"} ! 4-hydroxybenzoyl-CoA relationship: part_of UPa:UER01021 {cardinality="1", direction="LR", order="1"} ! 4-hydroxybenzoate from 4-chlorobenzoate: step 2/3 [Term] id: UPa:UCR04109 name: H(+) + L-glutamyl-tRNA(Glu) + NADPH = (S)-4-amino-5-oxopentanoic acid + NADP(+) + tRNA(Glu) namespace: reaction xref: KEGG:R04109 "KEGG reaction" xref: METACYC:GLUTRNAREDUCT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12347 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC02987 {cardinality="1"} ! L-glutamyl-tRNA(Glu) relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC01641 {cardinality="1"} ! tRNA(Glu) relationship: has_output_compound UPa:UPC03741 {cardinality="1"} ! (S)-4-amino-5-oxopentanoic acid relationship: part_of UPa:UER00316 {cardinality="1", direction="LR", order="1"} ! 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2 [Term] id: UPa:UCR04138 name: 3-methylcrotonyl-CoA + ATP + bicarbonate = 3-methylglutaconyl-CoA + ADP + phosphate namespace: reaction xref: KEGG:R04138 "KEGG reaction" xref: METACYC:METHYLCROTONYL-COA-CARBOXYLASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13592 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC03069 {cardinality="1"} ! 3-methylcrotonyl-CoA relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC03231 {cardinality="1"} ! 3-methylglutaconyl-CoA relationship: part_of UPa:UER00861 {cardinality="1", direction="LR", order="1"} ! (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3 [Term] id: UPa:UCR04142 name: 5-acetamidopentanoate + CO(2) + H(+) + NADH = 6-acetamido-2-oxohexanoate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R04142 "KEGG reaction" xref: METACYC:KETAMID-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42511 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC03087 {cardinality="1"} ! 5-acetamidopentanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC05548 {cardinality="1"} ! 6-acetamido-2-oxohexanoate relationship: part_of UPa:UER00843 {cardinality="1", direction="RL", order="1"} ! glutarate from L-lysine: step 3/6 [Term] id: UPa:UCR04143 name: 5-methylthio-alpha-D-ribose + ATP = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate namespace: reaction xref: KEGG:R04143 "KEGG reaction" xref: METACYC:5-METHYLTHIORIBOSE-KINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22315 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC03089 {cardinality="1"} ! 5-methylthio-alpha-D-ribose relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: part_of UPa:UER00872 {cardinality="1", direction="LR", order="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2 [Term] id: UPa:UCR04144 name: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate namespace: reaction xref: KEGG:R04144 "KEGG reaction" xref: METACYC:GLYRIBONUCSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17456 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_input_compound UPa:UPC03090 {cardinality="1"} ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00125 {cardinality="1", direction="LR", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2 [Term] id: UPa:UCR04148 name: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = H(+) + alpha-ribazole 5'-phosphate + nicotinate namespace: reaction xref: KEGG:R04148 "KEGG reaction" xref: METACYC:DMBPPRIBOSYLTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11199 "Rhea reaction" relationship: has_input_compound UPa:UPC01185 {cardinality="1"} ! nicotinate D-ribonucleotide relationship: has_input_compound UPa:UPC03114 {cardinality="1"} ! 5,6-dimethylbenzimidazole relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00253 {cardinality="1"} ! nicotinate relationship: has_output_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate relationship: part_of UPa:UER00516 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2 [Term] id: UPa:UCR04173 name: 2-oxoglutarate + O-phospho-L-serine = 3-phosphohydroxypyruvate + L-glutamate namespace: reaction xref: KEGG:R04173 "KEGG reaction" xref: METACYC:PSERTRANSAM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14332 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC01005 {cardinality="1"} ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC03232 {cardinality="1"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:UER00197 {cardinality="1", direction="RL", order="1"} ! L-serine from 3-phospho-D-glycerate: step 2/3 [Term] id: UPa:UCR04189 name: 2 H(2)O + N(2)-succinyl-L-arginine = CO(2) + N(2)-succinyl-L-ornithine + 2 NH(3) namespace: reaction xref: KEGG:R04189 "KEGG reaction" xref: METACYC:SUCCARGDIHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19536 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03296 {cardinality="1"} ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine relationship: part_of UPa:UER00280 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 2/5 [Term] id: UPa:UCR04198 name: (S)-tetrahydrodipicolinate + H(2)O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH namespace: reaction xref: KEGG:R04198 "KEGG reaction" xref: RHEA:35326 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER01028 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR04199 name: (S)-tetrahydrodipicolinate + H(2)O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH namespace: reaction xref: KEGG:R04199 "KEGG reaction" xref: RHEA:35334 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER01029 {cardinality="1", direction="RL", order="1"} ! None [Term] id: UPa:UCR04208 name: 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate namespace: reaction xref: KEGG:R04208 "KEGG reaction" xref: METACYC:AIRS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23035 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00129 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2 [Term] id: UPa:UCR04209 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2) namespace: reaction xref: KEGG:R04209 "KEGG reaction" xref: METACYC:AIRCARBOXY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10795 "Rhea reaction" relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00130 {cardinality="1", direction="RL", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1 [Term] id: UPa:UCR04210 name: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + H(+) + NADH namespace: reaction xref: KEGG:R04210 "KEGG reaction" xref: METACYC:ERYTHRON4PDEHYDROG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18832 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC03393 {cardinality="1"} ! 4-phospho-D-erythronate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: part_of UPa:UER00310 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5 [Term] id: UPa:UCR04217 name: 2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde namespace: reaction xref: KEGG:R04217 "KEGG reaction" xref: METACYC:SUCCORNTRANSAM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16956 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC03415 {cardinality="1"} ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: part_of UPa:UER00281 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 3/5 [Term] id: UPa:UCR04218 name: prephytoene diphosphate = 15-cis-phytoene + diphosphate namespace: reaction xref: KEGG:R04218 "KEGG reaction" xref: RHEA:34482 "Rhea reaction" relationship: has_input_compound UPa:UPC03427 {cardinality="1"} ! prephytoene diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05421 {cardinality="1"} ! 15-cis-phytoene relationship: part_of UPa:UER01030 {cardinality="1", direction="LR", order="2"} ! 15-cis-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR04231 name: (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + N-[(R)-4-phosphonopantothenoyl]-L-cysteine + diphosphate namespace: reaction xref: KEGG:R04231 "KEGG reaction" xref: METACYC:P-PANTOCYSLIG-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19400 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC03492 {cardinality="1"} ! (R)-4'-phosphopantothenate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC04352 {cardinality="1"} ! N-[(R)-4-phosphonopantothenoyl]-L-cysteine relationship: part_of UPa:UER00353 {cardinality="1", direction="LR", order="1"} ! CoA from (R)-pantothenate: step 2/5 [Term] id: UPa:UCR04265 name: CDP-3,6-dideoxy-D-glucose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-D-glucose + H(+) + NADPH namespace: reaction xref: KEGG:R04265 "KEGG reaction" xref: METACYC:RXN-9159 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34570 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04297 {cardinality="1"} ! CDP-4-dehydro-3,6-dideoxy-D-glucose relationship: part_of UPa:UER00514 {cardinality="1", direction="RL", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 4/5 [Term] id: UPa:UCR04266 name: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose namespace: reaction xref: KEGG:R04266 "KEGG reaction" xref: METACYC:RXN-9160 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21659 "Rhea reaction" relationship: has_input_compound UPa:UPC03598 {cardinality="1"} ! CDP-3,6-dideoxy-D-glucose relationship: has_output_compound UPa:UPC03599 {cardinality="1"} ! CDP-3,6-dideoxy-D-mannose relationship: part_of UPa:UER00515 {cardinality="1", direction="LR", order="1"} ! CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate: step 5/5 [Term] id: UPa:UCR04285 name: 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-tetrahydropterin + H(+) + NADPH namespace: reaction xref: KEGG:R04285 "KEGG reaction" xref: METACYC:1.1.1.220-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11775 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04244 {cardinality="1"} ! 6-lactoyl-5,6,7,8-tetrahydropterin relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin relationship: part_of UPa:UER00820 {cardinality="1", direction="RL", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 2/3 [Term] id: UPa:UCR04286 name: 7,8-dihydroneopterin triphosphate = 6-pyruvoyl-tetrahydropterin + triphosphate namespace: reaction xref: KEGG:R04286 "KEGG reaction" xref: METACYC:4.2.3.12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22051 "Rhea reaction" relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate relationship: has_output_compound UPa:UPC03684 {cardinality="1"} ! 6-pyruvoyl-tetrahydropterin relationship: part_of UPa:UER00819 {cardinality="1", direction="LR", order="1"} ! tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3 [Term] id: UPa:UCR04292 name: 2 H(2)O + phosphate + quinolinate = glycerone phosphate + iminoaspartate namespace: reaction xref: KEGG:R04292 "KEGG reaction" xref: METACYC:QUINOLINATE-SYNTHA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25891 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00327 {cardinality="1", direction="RL", order="1"} ! quinolinate from iminoaspartate: step 1/1 [Term] id: UPa:UCR04293 name: H(2)O + quinolinate = 2-amino-3-carboxymuconate semialdehyde namespace: reaction xref: KEGG:R04293 "KEGG reaction" xref: METACYC:RXN-5721 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25150 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC03722 {cardinality="1"} ! quinolinate relationship: has_output_compound UPa:UPC04409 {cardinality="1"} ! 2-amino-3-carboxymuconate semialdehyde relationship: part_of UPa:UER00330 {cardinality="1", direction="RL", order="2"} ! quinolinate from L-kynurenine: step 3/3 [Term] id: UPa:UCR04296 name: (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = UDP + dhurrin namespace: reaction xref: KEGG:R04296 "KEGG reaction" xref: METACYC:RXN-743 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12856 "Rhea reaction" relationship: has_input_compound UPa:UPC00029 {cardinality="1"} ! UDP-alpha-D-glucose relationship: has_input_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC05143 {cardinality="1"} ! dhurrin relationship: part_of UPa:UER00746 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 3/3 [Term] id: UPa:UCR04325 name: 10-formyl-5,6,7,8-tetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = 5,6,7,8-tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide namespace: reaction xref: KEGG:R04325 "KEGG reaction" xref: METACYC:GART-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15056 "Rhea reaction" relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00126 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1 [Term] id: UPa:UCR04336 name: (S)-2-amino-6-oxopimelate = (S)-tetrahydrodipicolinate + H(2)O namespace: reaction xref: KEGG:R04336 "KEGG reaction" xref: METACYC:RXN-4821 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24800 "Rhea reaction" relationship: has_input_compound UPa:UPC03871 {cardinality="1"} ! (S)-2-amino-6-oxopimelate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00026 {cardinality="1", direction="RL", order="1"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 [Term] id: UPa:UCR04347 name: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M namespace: reaction xref: KEGG:R04347 "KEGG reaction" xref: METACYC:2.1.1.86-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17588 "Rhea reaction" relationship: has_input_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M relationship: has_input_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: part_of UPa:UER00698 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2 [Term] id: UPa:UCR04364 name: (S)-tetrahydrodipicolinate + H(2)O + acetyl-CoA = (S)-2-acetamido-6-oxopimelate + CoA namespace: reaction xref: KEGG:R04364 "KEGG reaction" xref: METACYC:2.3.1.89-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13088 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:UER00022 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3 [Term] id: UPa:UCR04365 name: (S)-tetrahydrodipicolinate + H(2)O + succinyl-CoA = CoA + L-2-succinylamino-6-oxopimelate namespace: reaction xref: KEGG:R04365 "KEGG reaction" xref: METACYC:TETHYDPICSUCC-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17328 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:UER00019 {cardinality="1", direction="LR", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3 [Term] id: UPa:UCR04371 name: homoisocitrate = H(2)O + homo-cis-aconitate namespace: reaction xref: KEGG:R04371 "KEGG reaction" xref: METACYC:HOMOACONITATE-HYDRATASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15488 "Rhea reaction" relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04002 {cardinality="1"} ! homo-cis-aconitate relationship: part_of UPa:UER01027 {cardinality="1", direction="RL", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 3/5 [Term] id: UPa:UCR04376 name: 3-(2,3-dihydroxyphenyl)propanoate + O(2) = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate namespace: reaction xref: KEGG:R04376 "KEGG reaction" xref: METACYC:1.13.11.16-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23843 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC04479 {cardinality="1"} ! 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate relationship: part_of UPa:UER00794 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from 3-(2,3-dihydroxyphenyl)propanoate: step 1/4 [Term] id: UPa:UCR04379 name: 5-carboxymethyl-2-hydroxymuconic acid = 5-oxopent-3-ene-1,2,5-tricarboxylic acid namespace: reaction xref: KEGG:R04379 "KEGG reaction" xref: METACYC:5.3.3.10-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18816 "Rhea reaction" relationship: has_input_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: has_output_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: part_of UPa:UER00419 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7 [Term] id: UPa:UCR04380 name: 5-oxopent-3-ene-1,2,5-tricarboxylic acid = 2-hydroxy-hept-2,4-diene-1,7-dioic acid + CO(2) namespace: reaction xref: KEGG:R04380 "KEGG reaction" xref: METACYC:CARBOXY-OXOHEPT-ENEDIOATE-DECARBOXY-RXN "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC04052 {cardinality="1"} ! 5-oxopent-3-ene-1,2,5-tricarboxylic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: part_of UPa:UER00420 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7 [Term] id: UPa:UCR04382 name: 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid = 2 5-dehydro-4-deoxy-D-glucuronic acid namespace: reaction xref: KEGG:R04382 "KEGG reaction" xref: METACYC:OLIGOGALACTURONIDE-LYASE-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:20272 "Rhea reaction" relationship: has_input_compound UPa:UPC06118 {cardinality="1"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: part_of UPa:UER00825 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 3/5 [Term] id: UPa:UCR04383 name: 5-dehydro-4-deoxy-D-glucuronic acid = 3-deoxy-D-glycero-hexo-2,5-diulosonate namespace: reaction xref: KEGG:R04383 "KEGG reaction" xref: METACYC:5.3.1.17-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23899 "Rhea reaction" relationship: has_input_compound UPa:UPC04053 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC04349 {cardinality="1"} ! 3-deoxy-D-glycero-hexo-2,5-diulosonate relationship: part_of UPa:UER00826 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5 [Term] id: UPa:UCR04390 name: H(+) + NADPH + alpha-aminoadipoyl-S-acyl enzyme = L-2-aminoadipate 6-semialdahyde + NADP(+) + holo-Lys2 namespace: reaction xref: KEGG:R04390 "KEGG reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2 relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="3"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR04393 name: lactose + protein N(pi)-phospho-L-histidine = lactose 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R04393 "KEGG reaction" xref: RHEA:42403 "Rhea reaction" relationship: has_input_compound UPa:UPC00243 {cardinality="1"} ! lactose relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC05396 {cardinality="1"} ! lactose 6-phosphate relationship: part_of UPa:UER00604 {cardinality="1", direction="LR", order="1"} ! lactose 6-phosphate from lactose (PTS route): step 1/1 [Term] id: UPa:UCR04405 name: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate namespace: reaction xref: KEGG:R04405 "KEGG reaction" xref: METACYC:HOMOCYSMET-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21199 "Rhea reaction" relationship: has_input_compound UPa:UPC00155 {cardinality="1"} ! L-homocysteine relationship: has_input_compound UPa:UPC04489 {cardinality="1"} ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC04144 {cardinality="1"} ! tetrahydropteroyltri-L-glutamate relationship: part_of UPa:UER00082 {cardinality="1", direction="LR", order="1"} ! L-methionine from L-homocysteine (MetE route): step 1/1 [Term] id: UPa:UCR04418 name: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 5-carboxymethyl-2-hydroxymuconic acid + H(+) + NADH namespace: reaction xref: KEGG:R04418 "KEGG reaction" xref: METACYC:CHMS-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15684 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04642 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconate semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04186 {cardinality="1"} ! 5-carboxymethyl-2-hydroxymuconic acid relationship: part_of UPa:UER00418 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7 [Term] id: UPa:UCR04420 name: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate namespace: reaction xref: KEGG:R04420 "KEGG reaction" xref: METACYC:5.3.1.23-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19992 "Rhea reaction" relationship: has_input_compound UPa:UPC04188 {cardinality="1"} ! S-methyl-5-thio-alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: part_of UPa:UER00874 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6 [Term] id: UPa:UCR04426 name: (2R,3S)-3-isopropylmalate + NAD(+) = 3-carboxy-4-methyl-2-oxopentanoate + H(+) + NADH namespace: reaction xref: KEGG:R04426 "KEGG reaction" xref: METACYC:3-ISOPROPYLMALDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10895 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04411 {cardinality="1"} ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04236 {cardinality="1"} ! 3-carboxy-4-methyl-2-oxopentanoate relationship: part_of UPa:UER00072 {cardinality="1", direction="LR", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate: step 3/4 [Term] id: UPa:UCR04427 name: S-adenosyl-L-methionine + zymosterol = S-adenosyl-L-homocysteine + fecosterol namespace: reaction xref: KEGG:R04427 "KEGG reaction" xref: METACYC:RXN3O-178 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21131 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC04525 {cardinality="1"} ! fecosterol relationship: part_of UPa:UER00760 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 1/5 [Term] id: UPa:UCR04440 name: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 2-oxo-3-hydroxyisovalerate + H(+) + NADPH namespace: reaction xref: KEGG:R04440 "KEGG reaction" xref: RHEA:31142 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate relationship: part_of UPa:UER00060 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 2/4 [Term] id: UPa:UCR04441 name: (R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O namespace: reaction xref: KEGG:R04441 "KEGG reaction" xref: METACYC:DIHYDROXYISOVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24812 "Rhea reaction" relationship: has_input_compound UPa:UPC04272 {cardinality="1"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00141 {cardinality="1"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:UER00061 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 3/4 [Term] id: UPa:UCR04448 name: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP namespace: reaction xref: KEGG:R04448 "KEGG reaction" xref: METACYC:THIAZOLSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24215 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04294 {cardinality="1"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UER00139 {cardinality="1", direction="LR", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1 [Term] id: UPa:UCR04455 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylene-5,6,7,8-tetrahydromethanopterin + H(+) namespace: reaction xref: KEGG:R04455 "KEGG reaction" xref: METACYC:H2-METHYLENE-THMPT-DEHYDRO-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20020 "Rhea reaction" relationship: has_input_compound UPa:UPC00282 {cardinality="1"} ! H(2) relationship: has_input_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00696 {cardinality="1", direction="LR", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1 [Term] id: UPa:UCR04456 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin + coenzyme F420 = 1,5-dihydro-coenzyme F(420) + 5,10-methenyl-5,6,7,8-tetrahydromethanopterin namespace: reaction xref: KEGG:R04456 "KEGG reaction" xref: METACYC:1.5.99.9-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16724 "Rhea reaction" relationship: has_input_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420 relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420) relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00695 {cardinality="1", direction="RL", order="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1 [Term] id: UPa:UCR04457 name: 2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H(2)O + phosphate namespace: reaction xref: KEGG:R04457 "KEGG reaction" xref: METACYC:LUMAZINESYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:26155 "Rhea reaction" relationship: has_input_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: has_input_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04332 {cardinality="1"} ! 6,7-dimethyl-8-(1-D-ribityl)lumazine relationship: part_of UPa:UER00404 {cardinality="1", direction="LR", order="1"} ! riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2 [Term] id: UPa:UCR04463 name: ATP + H(2)O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + L-glutamate + phosphate namespace: reaction xref: KEGG:R04463 "KEGG reaction" xref: METACYC:FGAMSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17132 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC04640 {cardinality="1"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: part_of UPa:UER00128 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2 [Term] id: UPa:UCR04464 name: 1,5-dihydro-coenzyme F(420) + 5,10-methylene-5,6,7,8-tetrahydromethanopterin = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420 namespace: reaction xref: KEGG:R04464 "KEGG reaction" xref: METACYC:METHELENE-THMPT-OXI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:21147 "Rhea reaction" relationship: has_input_compound UPa:UPC01080 {cardinality="1"} ! 1,5-dihydro-coenzyme F(420) relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00876 {cardinality="1"} ! coenzyme F420 relationship: has_output_compound UPa:UPC04488 {cardinality="1"} ! 5-methyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00697 {cardinality="1", direction="LR", order="1"} ! methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2 [Term] id: UPa:UCR04467 name: 2-oxoglutarate + N-acetyl-LL-2,6-diaminopimelate = (S)-2-acetamido-6-oxopimelate + L-glutamate namespace: reaction xref: KEGG:R04467 "KEGG reaction" xref: METACYC:RXN-4822 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25318 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC04390 {cardinality="1"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC05539 {cardinality="1"} ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:UER00023 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3 [Term] id: UPa:UCR04475 name: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate namespace: reaction xref: KEGG:R04475 "KEGG reaction" xref: METACYC:SUCCINYLDIAMINOPIMTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11963 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC04421 {cardinality="1"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC04462 {cardinality="1"} ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:UER00020 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3 [Term] id: UPa:UCR04509 name: 4-amino-2-methyl-5-phosphomethylpyrimidine + ATP = 4-amino-2-methyl-5-diphosphomethylpyrimidine + ADP namespace: reaction xref: KEGG:R04509 "KEGG reaction" xref: METACYC:PYRIMSYN3-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19896 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04556 {cardinality="1"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04752 {cardinality="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: part_of UPa:UER00138 {cardinality="1", direction="LR", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3 [Term] id: UPa:UCR04540 name: coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine namespace: reaction xref: KEGG:R04540 "KEGG reaction" xref: METACYC:1.8.98.1-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:18088 "Rhea reaction" relationship: has_input_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide relationship: has_input_compound UPa:UPC11904 {cardinality="1"} ! dihydromethanophenazine relationship: has_output_compound UPa:UPC03576 {cardinality="1"} ! coenzyme M relationship: has_output_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B relationship: has_output_compound UPa:UPC11903 {cardinality="1"} ! methanophenazine relationship: part_of UPa:UER00700 {cardinality="1", direction="LR", order="1"} ! coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1 [Term] id: UPa:UCR04541 name: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane namespace: reaction xref: KEGG:R04541 "KEGG reaction" xref: METACYC:METHYL-COM-HTP-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12535 "Rhea reaction" relationship: has_input_compound UPa:UPC03920 {cardinality="1"} ! methyl-coenzyme M relationship: has_input_compound UPa:UPC04628 {cardinality="1"} ! coenzyme B relationship: has_output_compound UPa:UPC01438 {cardinality="1"} ! methane relationship: has_output_compound UPa:UPC04832 {cardinality="1"} ! coenzyme M-coenzyme B heterodisulfide relationship: part_of UPa:UER00699 {cardinality="1", direction="LR", order="1"} ! methane from methyl-coenzyme M: step 1/1 [Term] id: UPa:UCR04549 name: H(2)O + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = UMP + lipid X namespace: reaction xref: KEGG:R04549 "KEGG reaction" xref: METACYC:LIPIDXSYNTHESIS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25216 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00105 {cardinality="1"} ! UMP relationship: has_output_compound UPa:UPC04824 {cardinality="1"} ! lipid X relationship: part_of UPa:UER00480 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6 [Term] id: UPa:UCR04550 name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine = UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + acyl-carrier protein namespace: reaction xref: KEGG:R04550 "KEGG reaction" xref: RHEA:17820 "Rhea reaction" relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:UER00479 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6 [Term] id: UPa:UCR04558 name: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate namespace: reaction xref: KEGG:R04558 "KEGG reaction" xref: METACYC:GLUTAMIDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24796 "Rhea reaction" relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC04666 {cardinality="1"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00010 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9 relationship: part_of UPa:UER00899 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide: step 1/1 [Term] id: UPa:UCR04559 name: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate namespace: reaction xref: KEGG:R04559 "KEGG reaction" xref: METACYC:AICARSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23923 "Rhea reaction" relationship: has_input_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC00122 {cardinality="1"} ! fumarate relationship: has_output_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00132 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2 [Term] id: UPa:UCR04560 name: 10-formyl-5,6,7,8-tetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = 5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R04560 "KEGG reaction" xref: METACYC:AICARTRANSFORM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22195 "Rhea reaction" relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00133 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1 [Term] id: UPa:UCR04567 name: (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + acyl-carrier protein namespace: reaction xref: KEGG:R04567 "KEGG reaction" xref: RHEA:13928 "Rhea reaction" relationship: has_input_compound UPa:UPC00043 {cardinality="1"} ! UDP-N-acetyl-alpha-D-glucosamine relationship: has_input_compound UPa:UPC04688 {cardinality="1"} ! (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: part_of UPa:UER00477 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6 [Term] id: UPa:UCR04587 name: H(2)O + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine = UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine + acetate namespace: reaction xref: KEGG:R04587 "KEGG reaction" xref: METACYC:UDPACYLGLCNACDEACETYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25212 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04738 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine relationship: has_output_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_output_compound UPa:UPC06022 {cardinality="1"} ! UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine relationship: part_of UPa:UER00478 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6 [Term] id: UPa:UCR04591 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid + ADP + phosphate namespace: reaction xref: KEGG:R04591 "KEGG reaction" xref: METACYC:SAICARSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22631 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_input_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04823 {cardinality="1"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: part_of UPa:UER00131 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2 [Term] id: UPa:UCR04594 name: H(2)O + alpha-ribazole 5'-phosphate = alpha-ribazole + phosphate namespace: reaction xref: KEGG:R04594 "KEGG reaction" xref: METACYC:RIBAZOLEPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24459 "Rhea reaction" xref: RHEA:30370 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04778 {cardinality="1"} ! alpha-ribazole 5'-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole relationship: part_of UPa:UER00517 {cardinality="1", direction="LR", order="1"} ! alpha-ribazole from 5,6-dimethylbenzimidazole: step 2/2 [Term] id: UPa:UCR04606 name: UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine + lipid X = 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + UDP namespace: reaction xref: KEGG:R04606 "KEGG reaction" xref: METACYC:LIPIDADISACCHARIDESYNTH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22671 "Rhea reaction" relationship: has_input_compound UPa:UPC04652 {cardinality="1"} ! UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine relationship: has_input_compound UPa:UPC04824 {cardinality="1"} ! lipid X relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: part_of UPa:UER00481 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6 [Term] id: UPa:UCR04621 name: 7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H(2)O namespace: reaction xref: KEGG:R04621 "KEGG reaction" xref: METACYC:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25309 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC04874 {cardinality="1"} ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:UER00153 {cardinality="1", direction="RL", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4 [Term] id: UPa:UCR04638 name: 7,8-dihydroneopterin triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate namespace: reaction xref: KEGG:R04638 "KEGG reaction" xref: METACYC:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25305 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05925 {cardinality="1"} ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:UER00152 {cardinality="1", direction="LR", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4 [Term] id: UPa:UCR04639 name: 7,8-dihydroneopterin triphosphate + H(2)O = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine namespace: reaction xref: KEGG:R04639 "KEGG reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04895 {cardinality="1"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: part_of UPa:UER00151 {cardinality="1", direction="RL", order="4"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR04640 name: 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide = 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide namespace: reaction xref: KEGG:R04640 "KEGG reaction" xref: METACYC:PRIBFAICARPISOM-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15472 "Rhea reaction" relationship: has_input_compound UPa:UPC04896 {cardinality="1"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 {cardinality="1"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00009 {cardinality="1", direction="LR", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 [Term] id: UPa:UCR04657 name: 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + ATP = ADP + lipid IV(A) namespace: reaction xref: KEGG:R04657 "KEGG reaction" xref: METACYC:TETRAACYLDISACC4KIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20703 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC04932 {cardinality="1"} ! 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: part_of UPa:UER00482 {cardinality="1", direction="LR", order="1"} ! lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6 [Term] id: UPa:UCR04658 name: CMP-3-deoxy-D-manno-octulosonate + lipid IV(A) = 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP namespace: reaction xref: KEGG:R04658 "KEGG reaction" xref: METACYC:KDOTRANS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28069 "Rhea reaction" relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC04919 {cardinality="1"} ! lipid IV(A) relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: part_of UPa:UER00483 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4 [Term] id: UPa:UCR04672 name: (S)-2-acetolactate + thiamine diphosphate = 2-hydroxyethyl-ThPP + pyruvate namespace: reaction xref: KEGG:R04672 "KEGG reaction" xref: METACYC:RXN-14037 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24808 "Rhea reaction" relationship: has_input_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: part_of UPa:UER00059 {cardinality="1", direction="RL", order="2"} ! L-valine from pyruvate: step 1/4 [Term] id: UPa:UCR04673 name: 2-hydroxyethyl-ThPP + 2-oxobutanoate = (S)-2-acetyl-2-hydroxybutanoic acid + thiamine diphosphate namespace: reaction xref: KEGG:R04673 "KEGG reaction" xref: RHEA:33694 "Rhea reaction" relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC05125 {cardinality="1"} ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC00068 {cardinality="1"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: part_of UPa:UER00055 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 1/4 [Term] id: UPa:UCR04692 name: (S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R04692 "KEGG reaction" xref: METACYC:2.1.1.140-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17412 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: part_of UPa:UER00442 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 2/4 [Term] id: UPa:UCR04694 name: 2 H(2)O + NADP(+) + berbamunine = (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + H(+) + NADPH + O(2) namespace: reaction xref: KEGG:R04694 "KEGG reaction" xref: METACYC:1.1.3.34-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23579 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC05177 {cardinality="1"} ! berbamunine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC05243 {cardinality="1"} ! (R)-N-methylcoclaurine relationship: part_of UPa:UER00446 {cardinality="1", direction="RL", order="1"} ! berbamunine from (R)-N-methylcoclaurine and (S)-N-methylcoclaurine: step 1/1 [Term] id: UPa:UCR04862 name: NAD(+) + homoisocitrate = 2-oxaloglutaric acid + H(+) + NADH namespace: reaction xref: KEGG:R04862 "KEGG reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC05662 {cardinality="1"} ! homoisocitrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05533 {cardinality="1"} ! 2-oxaloglutaric acid relationship: part_of UPa:UER00030 {cardinality="1", direction="LR", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 [Term] id: UPa:UCR04863 name: alpha-aminoadipoyl-C6-AMP + holo-Lys2 = AMP + alpha-aminoadipoyl-S-acyl enzyme namespace: reaction xref: KEGG:R04863 "KEGG reaction" relationship: has_input_compound UPa:UPC05560 {cardinality="1"} ! alpha-aminoadipoyl-C6-AMP relationship: has_input_compound UPa:UPC11482 {cardinality="1"} ! holo-Lys2 relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC05535 {cardinality="1"} ! alpha-aminoadipoyl-S-acyl enzyme relationship: part_of UPa:UER00032 {cardinality="1", direction="LR", order="2"} ! L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 [Term] id: UPa:UCR04868 name: H(2)O + isopenicillin N + phenylacetyl-CoA = CoA + L-alpha-aminoadipate + penicillin G namespace: reaction xref: KEGG:R04868 "KEGG reaction" xref: METACYC:2.3.1.164-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20723 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00582 {cardinality="1"} ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC05551 {cardinality="1"} ! penicillin G relationship: part_of UPa:UER00241 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3 [Term] id: UPa:UCR04870 name: 3 ATP + H(2)O + L-alpha-aminoadipate + L-cysteine + L-valine = 3 AMP + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 diphosphate namespace: reaction xref: KEGG:R04870 "KEGG reaction" xref: METACYC:6.3.2.26-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23199 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00097 {cardinality="1"} ! L-cysteine relationship: has_input_compound UPa:UPC00183 {cardinality="1"} ! L-valine relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: part_of UPa:UER00239 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3 [Term] id: UPa:UCR04872 name: N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N namespace: reaction xref: KEGG:R04872 "KEGG reaction" xref: METACYC:1.21.3.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22431 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC05556 {cardinality="1"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC05557 {cardinality="1"} ! isopenicillin N relationship: part_of UPa:UER00240 {cardinality="1", direction="LR", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3 [Term] id: UPa:UCR05046 name: H(2)O + formamidopyrimidine nucleoside triphosphate = 2,5-diaminopyrimidine nucleoside triphosphate + formate namespace: reaction xref: KEGG:R05046 "KEGG reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05922 {cardinality="1"} ! formamidopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="2"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR05048 name: 2,5-diaminopyrimidine nucleoside triphosphate = 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine namespace: reaction xref: KEGG:R05048 "KEGG reaction" relationship: has_input_compound UPa:UPC05923 {cardinality="1"} ! 2,5-diaminopyrimidine nucleoside triphosphate relationship: has_output_compound UPa:UPC06148 {cardinality="1"} ! 2,5-diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine relationship: part_of UPa:UER00151 {cardinality="1", direction="LR", order="3"} ! 7,8-dihydroneopterin triphosphate from GTP: step 1/1 [Term] id: UPa:UCR05049 name: H(2)O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = H(+) + N(2)-succinyl-L-glutamic acid + NADH namespace: reaction xref: KEGG:R05049 "KEGG reaction" xref: METACYC:SUCCGLUALDDEHYD-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10815 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC05932 {cardinality="1"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05931 {cardinality="1"} ! N(2)-succinyl-L-glutamic acid relationship: part_of UPa:UER00282 {cardinality="1", direction="LR", order="1"} ! L-glutamate and succinate from L-arginine: step 4/5 [Term] id: UPa:UCR05068 name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid + NADP(+) = (R)-3-hydroxy-3-methyl-2-oxopentanoate + H(+) + NADPH namespace: reaction xref: KEGG:R05068 "KEGG reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00056 {cardinality="1", direction="RL", order="2"} ! L-isoleucine from 2-oxobutanoate: step 2/4 [Term] id: UPa:UCR05069 name: (S)-2-acetyl-2-hydroxybutanoic acid = (R)-3-hydroxy-3-methyl-2-oxopentanoate namespace: reaction xref: KEGG:R05069 "KEGG reaction" xref: RHEA:25407 "Rhea reaction" relationship: has_input_compound UPa:UPC06006 {cardinality="1"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC14463 {cardinality="1"} ! (R)-3-hydroxy-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00056 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 2/4 [Term] id: UPa:UCR05070 name: (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid = (S)-3-methyl-2-oxopentanoate + H(2)O namespace: reaction xref: KEGG:R05070 "KEGG reaction" xref: METACYC:DIHYDROXYMETVALDEHYDRAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27697 "Rhea reaction" relationship: has_input_compound UPa:UPC06007 {cardinality="1"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00671 {cardinality="1"} ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:UER00057 {cardinality="1", direction="LR", order="1"} ! L-isoleucine from 2-oxobutanoate: step 3/4 [Term] id: UPa:UCR05071 name: (S)-2-acetolactate = 2-oxo-3-hydroxyisovalerate namespace: reaction xref: KEGG:R05071 "KEGG reaction" xref: METACYC:2-ACETOLACTATE-MUTASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31258 "Rhea reaction" relationship: has_input_compound UPa:UPC06010 {cardinality="1"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC04181 {cardinality="1"} ! 2-oxo-3-hydroxyisovalerate relationship: part_of UPa:UER00060 {cardinality="1", direction="LR", order="1"} ! L-valine from pyruvate: step 2/4 [Term] id: UPa:UCR05074 name: 3-deoxy-D-manno-octulosonyl-lipid IV((A)) + CMP-3-deoxy-D-manno-octulosonate = CMP + di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) namespace: reaction xref: KEGG:R05074 "KEGG reaction" xref: METACYC:KDOTRANS2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28065 "Rhea reaction" relationship: has_input_compound UPa:UPC04121 {cardinality="1"} ! CMP-3-deoxy-D-manno-octulosonate relationship: has_input_compound UPa:UPC06024 {cardinality="1"} ! 3-deoxy-D-manno-octulosonyl-lipid IV((A)) relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: part_of UPa:UER00484 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4 [Term] id: UPa:UCR05075 name: lauroyl-KDO(2)-lipid IV(A) + tetradecanoyl-[acp] = KDO(2)-lipid A + acyl-carrier protein namespace: reaction xref: KEGG:R05075 "KEGG reaction" xref: RHEA:28441 "Rhea reaction" relationship: has_input_compound UPa:UPC05761 {cardinality="1"} ! tetradecanoyl-[acp] relationship: has_input_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A) relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC06026 {cardinality="1"} ! KDO(2)-lipid A relationship: part_of UPa:UER00486 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4 [Term] id: UPa:UCR05085 name: 2-oxoglutarate + 4-(phosphonooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid + L-glutamate namespace: reaction xref: KEGG:R05085 "KEGG reaction" xref: METACYC:PSERTRANSAMPYR-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16576 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06054 {cardinality="1"} ! (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoic acid relationship: part_of UPa:UER00311 {cardinality="1", direction="RL", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5 [Term] id: UPa:UCR05123 name: (S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R05123 "KEGG reaction" xref: METACYC:2.1.1.128-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31910 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06160 {cardinality="1"} ! (S)-norcoclaurine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06161 {cardinality="1"} ! (S)-coclaurine relationship: part_of UPa:UER00441 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 1/4 [Term] id: UPa:UCR05146 name: di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) + dodecanoyl-[acyl-carrier protein] = acyl-carrier protein + lauroyl-KDO(2)-lipid IV(A) namespace: reaction xref: KEGG:R05146 "KEGG reaction" xref: RHEA:28445 "Rhea reaction" relationship: has_input_compound UPa:UPC05223 {cardinality="1"} ! dodecanoyl-[acyl-carrier protein] relationship: has_input_compound UPa:UPC06025 {cardinality="1"} ! di[3-deoxy-D-manno-octulosonyl]-lipid IV(A) relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC06251 {cardinality="1"} ! lauroyl-KDO(2)-lipid IV(A) relationship: part_of UPa:UER00485 {cardinality="1", direction="LR", order="1"} ! KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4 [Term] id: UPa:UCR05149 name: 2 S-adenosyl-L-methionine + precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + precorrin-8X namespace: reaction xref: KEGG:R05149 "KEGG reaction" xref: METACYC:2.1.1.132-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17480 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X relationship: part_of UPa:UER00218 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10 [Term] id: UPa:UCR05150 name: NADP(+) + precorrin-6B = H(+) + NADPH + precorrin-6A namespace: reaction xref: KEGG:R05150 "KEGG reaction" xref: METACYC:1.3.1.54-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23411 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC06319 {cardinality="1"} ! precorrin-6B relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A relationship: part_of UPa:UER00217 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10 [Term] id: UPa:UCR05176 name: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose namespace: reaction xref: KEGG:R05176 "KEGG reaction" xref: METACYC:5.1.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17580 "Rhea reaction" relationship: has_input_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose relationship: has_output_compound UPa:UPC06398 {cardinality="1"} ! ADP-L-glycero-beta-D-manno-heptose relationship: part_of UPa:UER00440 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4 [Term] id: UPa:UCR05177 name: precorrin-8X = hydrogenobyrinic acid namespace: reaction xref: KEGG:R05177 "KEGG reaction" xref: METACYC:5.4.1.2-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22515 "Rhea reaction" relationship: has_input_compound UPa:UPC06408 {cardinality="1"} ! precorrin-8X relationship: has_output_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid relationship: part_of UPa:UER00219 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10 [Term] id: UPa:UCR05180 name: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 namespace: reaction xref: KEGG:R05180 "KEGG reaction" xref: METACYC:2.1.1.131-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12764 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4 relationship: part_of UPa:UER00214 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10 [Term] id: UPa:UCR05181 name: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 namespace: reaction xref: KEGG:R05181 "KEGG reaction" xref: METACYC:2.1.1.133-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22015 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06407 {cardinality="1"} ! precorrin-4 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5 relationship: part_of UPa:UER00215 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10 [Term] id: UPa:UCR05217 name: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B namespace: reaction xref: KEGG:R05217 "KEGG reaction" xref: METACYC:R321-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17296 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05772 {cardinality="1"} ! precorrin-3A relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06406 {cardinality="1"} ! precorrin-3B relationship: part_of UPa:UER00213 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10 [Term] id: UPa:UCR05218 name: FMNH(2) + 2 cob(II)yrinate a,c-diamide = FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide namespace: reaction xref: KEGG:R05218 "KEGG reaction" xref: METACYC:R343-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24303 "Rhea reaction" relationship: has_input_compound UPa:UPC01847 {cardinality="1"} ! FMNH(2) relationship: has_input_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide relationship: part_of UPa:UER00232 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7 [Term] id: UPa:UCR05219 name: S-adenosyl-L-homocysteine + acetate + precorrin-6A = H(2)O + S-adenosyl-L-methionine + precorrin-5 namespace: reaction xref: KEGG:R05219 "KEGG reaction" xref: METACYC:R322-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18264 "Rhea reaction" relationship: has_input_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_input_compound UPa:UPC00033 {cardinality="1"} ! acetate relationship: has_input_compound UPa:UPC06320 {cardinality="1"} ! precorrin-6A relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_output_compound UPa:UPC06416 {cardinality="1"} ! precorrin-5 relationship: part_of UPa:UER00216 {cardinality="1", direction="RL", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10 [Term] id: UPa:UCR05220 name: ATP + cob(I)yrinic acid a,c-diamide = adenosylcob(III)yrinic acid a,c-diamide + triphosphate namespace: reaction xref: KEGG:R05220 "KEGG reaction" xref: METACYC:R344-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11531 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06505 {cardinality="1"} ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00536 {cardinality="1"} ! triphosphate relationship: has_output_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: part_of UPa:UER00233 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7 [Term] id: UPa:UCR05221 name: ATP + adenosylcobinamide = ADP + adenosylcobinamide phosphate namespace: reaction xref: KEGG:R05221 "KEGG reaction" xref: METACYC:COBINAMIDEKIN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15772 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: part_of UPa:UER00953 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR05222 name: GTP + adenosylcobinamide phosphate = adenosylcobinamide-GDP + diphosphate namespace: reaction xref: KEGG:R05222 "KEGG reaction" xref: METACYC:COBINPGUANYLYLTRANS-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22715 "Rhea reaction" relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP relationship: part_of UPa:UER00237 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7 [Term] id: UPa:UCR05223 name: GMP + adenosylcobalamin = adenosylcobinamide-GDP + alpha-ribazole namespace: reaction xref: KEGG:R05223 "KEGG reaction" xref: METACYC:COBALAMINSYN-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16052 "Rhea reaction" relationship: has_input_compound UPa:UPC00144 {cardinality="1"} ! GMP relationship: has_input_compound UPa:UPC00194 {cardinality="1"} ! adenosylcobalamin relationship: has_output_compound UPa:UPC05775 {cardinality="1"} ! alpha-ribazole relationship: has_output_compound UPa:UPC06510 {cardinality="1"} ! adenosylcobinamide-GDP relationship: part_of UPa:UER00238 {cardinality="1", direction="RL", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7 [Term] id: UPa:UCR05224 name: 2 ATP + 2 H(2)O + 2 L-glutamine + hydrogenobyrinic acid = 2 ADP + 2 L-glutamate + hydrogenobyrinic acid a,c-diamide + 2 phosphate namespace: reaction xref: KEGG:R05224 "KEGG reaction" xref: METACYC:R341-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:12547 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC06399 {cardinality="1"} ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide relationship: part_of UPa:UER00220 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10 [Term] id: UPa:UCR05225 name: 4 ATP + 4 H(2)O + 4 L-glutamine + adenosylcob(III)yrinic acid a,c-diamide = 4 ADP + 4 L-glutamate + adenosylcobyrinic acid a,c-diamide + 4 phosphate namespace: reaction xref: KEGG:R05225 "KEGG reaction" xref: METACYC:R345-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23259 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC06506 {cardinality="1"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide relationship: part_of UPa:UER00234 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7 [Term] id: UPa:UCR05226 name: (R)-1-aminopropan-2-ol + adenosylcobyrinic acid a,c-diamide = H(2)O + adenosylcobinamide namespace: reaction xref: KEGG:R05226 "KEGG reaction" xref: METACYC:R346-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23507 "Rhea reaction" relationship: has_input_compound UPa:UPC03194 {cardinality="1"} ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC06507 {cardinality="1"} ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: part_of UPa:UER00235 {cardinality="1", direction="LR", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7 [Term] id: UPa:UCR05227 name: ATP + Co(2+) + H(2)O + hydrogenobyrinic acid a,c-diamide = ADP + H(+) + cob(II)yrinate a,c-diamide + phosphate namespace: reaction xref: KEGG:R05227 "KEGG reaction" xref: METACYC:R342-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15344 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+) relationship: has_input_compound UPa:UPC06503 {cardinality="1"} ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UER00221 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10 [Term] id: UPa:UCR05239 name: NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol = H(+) + NADH + biphenyl-2,3-diol namespace: reaction xref: KEGG:R05239 "KEGG reaction" xref: METACYC:1.3.1.56-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17036 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC02526 {cardinality="1"} ! biphenyl-2,3-diol relationship: part_of UPa:UER00251 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4 [Term] id: UPa:UCR05240 name: NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid = 2,3-dihydroxy-p-cumic acid + H(+) + NADH namespace: reaction xref: KEGG:R05240 "KEGG reaction" xref: METACYC:RXN-665 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23775 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid relationship: part_of UPa:UER00902 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 2/7 [Term] id: UPa:UCR05247 name: H(+) + NADH + O(2) + p-cumate = NAD(+) + cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid namespace: reaction xref: KEGG:R05247 "KEGG reaction" xref: METACYC:RXN-664 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42347 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06578 {cardinality="1"} ! p-cumate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06579 {cardinality="1"} ! cis-2,3-dihydroxy-2,3-dihydro-p-cumic acid relationship: part_of UPa:UER00901 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 1/7 [Term] id: UPa:UCR05248 name: 2,3-dihydroxy-p-cumic acid + O(2) = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid namespace: reaction xref: KEGG:R05248 "KEGG reaction" xref: METACYC:RXN-666 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42571 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC06580 {cardinality="1"} ! 2,3-dihydroxy-p-cumic acid relationship: has_output_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:UER00903 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 3/7 [Term] id: UPa:UCR05263 name: H(+) + NADH + O(2) + biphenyl = NAD(+) + cis-3-phenylcyclohexa-3,5-diene-1,2-diol namespace: reaction xref: KEGG:R05263 "KEGG reaction" xref: METACYC:1.14.12.18-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18168 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06588 {cardinality="1"} ! biphenyl relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06589 {cardinality="1"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:UER00250 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4 [Term] id: UPa:UCR05275 name: NAD(+) + cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid = 4,5-dihydroxyphthalate + H(+) + NADH namespace: reaction xref: KEGG:R05275 "KEGG reaction" xref: METACYC:1.3.1.64-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13840 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC04783 {cardinality="1"} ! cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03233 {cardinality="1"} ! 4,5-dihydroxyphthalate relationship: part_of UPa:UER00729 {cardinality="1", direction="LR", order="1"} ! 3,4-dihydroxybenzoate from phthalate: step 2/3 [Term] id: UPa:UCR05284 name: 1,2-dichloroethane + H(2)O = 2-chloroethanol + HCl namespace: reaction xref: KEGG:R05284 "KEGG reaction" xref: METACYC:DHLAXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25188 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06752 {cardinality="1"} ! 1,2-dichloroethane relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: has_output_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol relationship: part_of UPa:UER00387 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 1/4 [Term] id: UPa:UCR05285 name: 2-chloroethanol + 2 ferricytochrome c = 2 H(+) + chloroacetaldehyde + 2 ferrocytochrome c namespace: reaction xref: KEGG:R05285 "KEGG reaction" relationship: has_input_compound UPa:UPC00125 {cardinality="1"} ! ferricytochrome c relationship: has_input_compound UPa:UPC06753 {cardinality="1"} ! 2-chloroethanol relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00126 {cardinality="1"} ! ferrocytochrome c relationship: has_output_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde relationship: part_of UPa:UER00388 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 2/4 [Term] id: UPa:UCR05286 name: H(2)O + NAD(+) + chloroacetaldehyde = H(+) + NADH + chloroacetic acid namespace: reaction xref: KEGG:R05286 "KEGG reaction" xref: METACYC:ALDXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:30050 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06754 {cardinality="1"} ! chloroacetaldehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid relationship: part_of UPa:UER00389 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 3/4 [Term] id: UPa:UCR05287 name: H(2)O + chloroacetic acid = HCl + glycolate namespace: reaction xref: KEGG:R05287 "KEGG reaction" xref: METACYC:DHLBXANAU-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25192 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06755 {cardinality="1"} ! chloroacetic acid relationship: has_output_compound UPa:UPC00160 {cardinality="1"} ! glycolate relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: part_of UPa:UER00390 {cardinality="1", direction="LR", order="1"} ! glycolate from 1,2-dichloroethane: step 4/4 [Term] id: UPa:UCR05320 name: 2-oxoglutarate + O(2) + taurine = CO(2) + aminoacetaldehyde + succinate + sulfite namespace: reaction xref: KEGG:R05320 "KEGG reaction" xref: METACYC:RXN0-299 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15912 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC06735 {cardinality="1"} ! aminoacetaldehyde relationship: part_of UPa:UER00542 {cardinality="1", direction="LR", order="1"} ! aminoacetaldehyde and sulfite from taurine: step 1/1 [Term] id: UPa:UCR05332 name: acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate namespace: reaction xref: KEGG:R05332 "KEGG reaction" xref: METACYC:2.3.1.157-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13728 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC06156 {cardinality="1"} ! alpha-D-glucosamine 1-phosphate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UER00532 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2 [Term] id: UPa:UCR05338 name: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate namespace: reaction xref: KEGG:R05338 "KEGG reaction" xref: METACYC:R10-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25204 "Rhea reaction" relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate relationship: part_of UPa:UER00434 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2 [Term] id: UPa:UCR05339 name: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate namespace: reaction xref: KEGG:R05339 "KEGG reaction" xref: METACYC:R12-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25903 "Rhea reaction" relationship: has_input_compound UPa:UPC06019 {cardinality="1"} ! D-arabino-3-hexulose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00435 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2 [Term] id: UPa:UCR05357 name: H(2)O + amidinoproclavaminic acid = proclavaminic acid + urea namespace: reaction xref: KEGG:R05357 "KEGG reaction" xref: METACYC:3.5.3.22-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17004 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid relationship: part_of UPa:UER00245 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8 [Term] id: UPa:UCR05360 name: 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + salicylate namespace: reaction xref: KEGG:R05360 "KEGG reaction" xref: METACYC:R608-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42471 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC00805 {cardinality="1"} ! salicylate relationship: part_of UPa:UER00778 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 3/3 [Term] id: UPa:UCR05361 name: 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid + H(2)O = 2-hydroxymuconate + catechol namespace: reaction xref: KEGG:R05361 "KEGG reaction" xref: RHEA:42483 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: has_output_compound UPa:UPC00090 {cardinality="1"} ! catechol relationship: has_output_compound UPa:UPC02501 {cardinality="1"} ! 2-hydroxymuconate relationship: part_of UPa:UER00781 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 3/3 [Term] id: UPa:UCR05364 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + H(2)O = 2-hydroxy-2,4-pentadienoate + 2-methylpropanoate namespace: reaction xref: KEGG:R05364 "KEGG reaction" xref: METACYC:RXN-668 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42579 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00596 {cardinality="1"} ! 2-hydroxy-2,4-pentadienoate relationship: has_output_compound UPa:UPC02632 {cardinality="1"} ! 2-methylpropanoate relationship: part_of UPa:UER00905 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 5/7 [Term] id: UPa:UCR05377 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid = 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid + CO(2) namespace: reaction xref: KEGG:R05377 "KEGG reaction" xref: METACYC:RXN-667 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42575 "Rhea reaction" relationship: has_input_compound UPa:UPC06581 {cardinality="1"} ! 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC06582 {cardinality="1"} ! 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid relationship: part_of UPa:UER00904 {cardinality="1", direction="LR", order="1"} ! acetaldehyde and pyruvate from p-cumate: step 4/7 [Term] id: UPa:UCR05378 name: 6-phospho-5-dehydro-2-deoxy-D-gluconic acid = 3-oxopropanoate + glycerone phosphate namespace: reaction xref: KEGG:R05378 "KEGG reaction" xref: METACYC:4.1.2.29-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13180 "Rhea reaction" relationship: has_input_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC00111 {cardinality="1"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00222 {cardinality="1"} ! 3-oxopropanoate relationship: part_of UPa:UER00147 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 6/7 [Term] id: UPa:UCR05411 name: O(2) + biphenyl-2,2',3-triol = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: reaction xref: KEGG:R05411 "KEGG reaction" xref: METACYC:R607-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42467 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol relationship: has_output_compound UPa:UPC07731 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:UER00777 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 2/3 [Term] id: UPa:UCR05413 name: 2,2',3-trihydroxy-diphenyl ether + O(2) = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid namespace: reaction xref: KEGG:R05413 "KEGG reaction" xref: METACYC:R604-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42479 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether relationship: has_output_compound UPa:UPC07734 {cardinality="1"} ! 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoic acid relationship: part_of UPa:UER00780 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 2/3 [Term] id: UPa:UCR05434 name: H(+) + NADH + O(2) + dibenzofuran = NAD(+) + biphenyl-2,2',3-triol namespace: reaction xref: KEGG:R05434 "KEGG reaction" xref: METACYC:R606-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42463 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC07729 {cardinality="1"} ! dibenzofuran relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC03569 {cardinality="1"} ! biphenyl-2,2',3-triol relationship: part_of UPa:UER00776 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-2,4-pentadienoate and salicylate from dibenzofuran: step 1/3 [Term] id: UPa:UCR05439 name: H(+) + NADH + O(2) + dibenzo-p-dioxin = 2,2',3-trihydroxy-diphenyl ether + NAD(+) namespace: reaction xref: KEGG:R05439 "KEGG reaction" xref: RHEA:42475 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC07732 {cardinality="1"} ! dibenzo-p-dioxin relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC07733 {cardinality="1"} ! 2,2',3-trihydroxy-diphenyl ether relationship: part_of UPa:UER00779 {cardinality="1", direction="LR", order="1"} ! 2-hydroxymuconate and catechol from dibenzo-p-dioxin: step 1/3 [Term] id: UPa:UCR05465 name: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + phosphate namespace: reaction xref: KEGG:R05465 "KEGG reaction" xref: METACYC:2.5.1.66-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10559 "Rhea reaction" relationship: has_input_compound UPa:UPC00062 {cardinality="1"} ! L-arginine relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: part_of UPa:UER00242 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8 [Term] id: UPa:UCR05466 name: 2-oxoglutarate + O(2) + deoxyamidinoproclavaminic acid = CO(2) + amidinoproclavaminic acid + succinate namespace: reaction xref: KEGG:R05466 "KEGG reaction" xref: METACYC:1.14.11.21-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20024 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC06657 {cardinality="1"} ! amidinoproclavaminic acid relationship: part_of UPa:UER00244 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8 [Term] id: UPa:UCR05467 name: ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminic acid + diphosphate namespace: reaction xref: KEGG:R05467 "KEGG reaction" xref: METACYC:6.3.3.4-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23623 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06655 {cardinality="1"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC06656 {cardinality="1"} ! deoxyamidinoproclavaminic acid relationship: part_of UPa:UER00243 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8 [Term] id: UPa:UCR05468 name: 2-oxoglutarate + O(2) + proclavaminic acid = CO(2) + H(2)O + dihydroclavaminic acid + succinate namespace: reaction xref: KEGG:R05468 "KEGG reaction" xref: METACYC:RXN-6266 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12776 "Rhea reaction" xref: RHEA:19788 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06658 {cardinality="1"} ! proclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid relationship: part_of UPa:UER00246 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8 [Term] id: UPa:UCR05469 name: 2-oxoglutarate + O(2) + dihydroclavaminic acid = CO(2) + H(2)O + clavaminate + succinate namespace: reaction xref: KEGG:R05469 "KEGG reaction" xref: METACYC:RXN-6267 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06659 {cardinality="1"} ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC06660 {cardinality="1"} ! clavaminate relationship: part_of UPa:UER00247 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8 [Term] id: UPa:UCR05470 name: clavaminate = clavulanate-9-aldehyde namespace: reaction xref: KEGG:R05470 "KEGG reaction" xref: METACYC:RXN-8892 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42431 "Rhea reaction" relationship: has_input_compound UPa:UPC06660 {cardinality="1"} ! clavaminate relationship: has_output_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde relationship: part_of UPa:UER00248 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8 [Term] id: UPa:UCR05471 name: H(+) + NADPH + clavulanate-9-aldehyde = NADP(+) + clavulanate namespace: reaction xref: KEGG:R05471 "KEGG reaction" xref: METACYC:RXN-8893 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:42071 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06661 {cardinality="1"} ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC06662 {cardinality="1"} ! clavulanate relationship: part_of UPa:UER00249 {cardinality="1", direction="LR", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8 [Term] id: UPa:UCR05552 name: NH(3) + chorismate = 4-amino-4-deoxychorismate + H(2)O namespace: reaction xref: KEGG:R05552 "KEGG reaction" relationship: has_input_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_input_compound UPa:UPC00251 {cardinality="1"} ! chorismate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate relationship: part_of UPa:UER00149 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 1/2 [Term] id: UPa:UCR05553 name: 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate namespace: reaction xref: KEGG:R05553 "KEGG reaction" xref: METACYC:ADCLY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16204 "Rhea reaction" relationship: has_input_compound UPa:UPC11355 {cardinality="1"} ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00568 {cardinality="1"} ! 4-aminobenzoate relationship: part_of UPa:UER00150 {cardinality="1", direction="LR", order="1"} ! 4-aminobenzoate from chorismate: step 2/2 [Term] id: UPa:UCR05554 name: 2-ureidoglycine + H(2)O = (S)-ureidoglycolate + NH(3) namespace: reaction xref: KEGG:R05554 "KEGG reaction" xref: METACYC:URUR-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25244 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC02091 {cardinality="1"} ! 2-ureidoglycine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00603 {cardinality="1"} ! (S)-ureidoglycolate relationship: part_of UPa:UER00655 {cardinality="1", direction="LR", order="2"} ! (S)-ureidoglycolate from allantoate (amidohydrolase route): step 1/1 [Term] id: UPa:UCR05558 name: H(2)O + atrazine = HCl + hydroxyatrazine namespace: reaction xref: KEGG:R05558 "KEGG reaction" xref: METACYC:3.8.1.8-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:11315 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06551 {cardinality="1"} ! atrazine relationship: has_output_compound UPa:UPC01327 {cardinality="1"} ! HCl relationship: has_output_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine relationship: part_of UPa:UER00499 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 1/3 [Term] id: UPa:UCR05559 name: H(2)O + hydroxyatrazine = N-isopropylammelide + ethylamine namespace: reaction xref: KEGG:R05559 "KEGG reaction" xref: METACYC:R122-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23095 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06552 {cardinality="1"} ! hydroxyatrazine relationship: has_output_compound UPa:UPC00797 {cardinality="1"} ! ethylamine relationship: has_output_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide relationship: part_of UPa:UER00500 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 2/3 [Term] id: UPa:UCR05560 name: H(2)O + N-isopropylammelide = cyanurate + isopropylamine namespace: reaction xref: KEGG:R05560 "KEGG reaction" xref: METACYC:R123-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23611 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06553 {cardinality="1"} ! N-isopropylammelide relationship: has_output_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: has_output_compound UPa:UPC06748 {cardinality="1"} ! isopropylamine relationship: part_of UPa:UER00501 {cardinality="1", direction="LR", order="1"} ! cyanurate from atrazine: step 3/3 [Term] id: UPa:UCR05605 name: 2-dehydro-3-deoxy-6-phospho-D-gluconic acid = D-glyceraldehyde 3-phosphate + pyruvate namespace: reaction xref: KEGG:R05605 "KEGG reaction" xref: METACYC:KDPGALDOL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17092 "Rhea reaction" relationship: has_input_compound UPa:UPC04442 {cardinality="1"} ! 2-dehydro-3-deoxy-6-phospho-D-gluconic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:UER00829 {cardinality="1", direction="LR", order="1"} ! D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2 [Term] id: UPa:UCR05608 name: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O namespace: reaction xref: KEGG:R05608 "KEGG reaction" xref: METACYC:GALACTARDEHYDRA-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16008 "Rhea reaction" relationship: has_input_compound UPa:UPC00879 {cardinality="1"} ! galactarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00679 {cardinality="1"} ! 5-dehydro-4-deoxy-D-glucarate relationship: part_of UPa:UER00629 {cardinality="1", direction="LR", order="1"} ! D-glycerate from galactarate: step 1/3 [Term] id: UPa:UCR05621 name: H(+) + NADH + O(2) + benzoate = (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + NAD(+) namespace: reaction xref: KEGG:R05621 "KEGG reaction" xref: METACYC:BENZOATE-12-DIOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12636 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1"} ! benzoate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC06321 {cardinality="1"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: part_of UPa:UER00254 {cardinality="1", direction="LR", order="1"} ! catechol from benzoate: step 1/2 [Term] id: UPa:UCR05633 name: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate namespace: reaction xref: KEGG:R05633 "KEGG reaction" xref: METACYC:2.7.7.60-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13432 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol relationship: part_of UPa:UER00093 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6 [Term] id: UPa:UCR05634 name: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP namespace: reaction xref: KEGG:R05634 "KEGG reaction" xref: METACYC:2.7.1.148-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18440 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC11435 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: part_of UPa:UER00094 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6 [Term] id: UPa:UCR05636 name: D-glyceraldehyde 3-phosphate + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2) namespace: reaction xref: KEGG:R05636 "KEGG reaction" xref: METACYC:DXS-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12608 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00118 {cardinality="1"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:UER00091 {cardinality="1", direction="LR", order="1"} ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1 [Term] id: UPa:UCR05637 name: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP namespace: reaction xref: KEGG:R05637 "KEGG reaction" xref: METACYC:RXN0-302 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23867 "Rhea reaction" relationship: has_input_compound UPa:UPC11436 {cardinality="1"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC11453 {cardinality="1"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: part_of UPa:UER00095 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6 [Term] id: UPa:UCR05639 name: 14-demethyllanosterol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH namespace: reaction xref: KEGG:R05639 "KEGG reaction" xref: METACYC:RXN66-306 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18564 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC05108 {cardinality="1"} ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: part_of UPa:UER00755 {cardinality="1", direction="RL", order="1"} ! zymosterol from lanosterol: step 2/6 [Term] id: UPa:UCR05640 name: 3 H(+) + 3 NADPH + 3 O(2) + lanosterol = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 4 H(2)O + 3 NADP(+) + formate namespace: reaction xref: KEGG:R05640 "KEGG reaction" xref: METACYC:RXN3O-130 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25289 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC01724 {cardinality="1"} ! lanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC11455 {cardinality="1"} ! 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol relationship: part_of UPa:UER00754 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 1/6 [Term] id: UPa:UCR05641 name: NADP(+) + ergosterol = H(+) + NADPH + ergosta-5,7,22,24(28)-tetraen-3beta-ol namespace: reaction xref: KEGG:R05641 "KEGG reaction" xref: METACYC:1.3.1.71-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18504 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC01694 {cardinality="1"} ! ergosterol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05440 {cardinality="1"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: part_of UPa:UER00764 {cardinality="1", direction="RL", order="1"} ! ergosterol from zymosterol: step 5/5 [Term] id: UPa:UCR05644 name: ATP + D-glycero-beta-D-manno-heptose 1-phosphate = ADP-D-glycero-beta-D-manno-heptose + diphosphate namespace: reaction xref: KEGG:R05644 "KEGG reaction" xref: METACYC:RXN0-4342 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27468 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06397 {cardinality="1"} ! ADP-D-glycero-beta-D-manno-heptose relationship: part_of UPa:UER00439 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4 [Term] id: UPa:UCR05646 name: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-diphosphate namespace: reaction xref: KEGG:R05646 "KEGG reaction" xref: RHEA:27476 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:UER00437 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4 [Term] id: UPa:UCR05647 name: D-glycero-beta-D-manno-heptose 1,7-diphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate namespace: reaction xref: KEGG:R05647 "KEGG reaction" xref: METACYC:RXN0-4361 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28521 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11472 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC07838 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 1-phosphate relationship: part_of UPa:UER00438 {cardinality="1", direction="LR", order="1"} ! ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 2/4 [Term] id: UPa:UCR05651 name: phosphate + sulfoacetaldehyde = acetyl phosphate + sulfite namespace: reaction xref: KEGG:R05651 "KEGG reaction" xref: METACYC:RXN-2364 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24207 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: has_output_compound UPa:UPC00227 {cardinality="1"} ! acetyl phosphate relationship: part_of UPa:UER00544 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 2/2 [Term] id: UPa:UCR05652 name: pyruvate + taurine = L-alanine + sulfoacetaldehyde namespace: reaction xref: KEGG:R05652 "KEGG reaction" xref: METACYC:TAURINE-AMINOTRANSFERASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:10423 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00245 {cardinality="1"} ! taurine relationship: has_output_compound UPa:UPC00041 {cardinality="1"} ! L-alanine relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: part_of UPa:UER00543 {cardinality="1", direction="LR", order="1"} ! acetyl phosphate and sulfite from taurine: step 1/2 [Term] id: UPa:UCR05661 name: 2-deoxy-5-keto-D-gluconic acid + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconic acid + ADP namespace: reaction xref: KEGG:R05661 "KEGG reaction" xref: METACYC:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13500 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06892 {cardinality="1"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC06893 {cardinality="1"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: part_of UPa:UER00146 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 5/7 [Term] id: UPa:UCR05681 name: 4-(phosphonooxy)-L-threonine + NAD(+) = 2-amino-3-oxo-4-phosphonooxybutyrate + H(+) + NADH namespace: reaction xref: KEGG:R05681 "KEGG reaction" xref: METACYC:1.1.1.262-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14456 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC06055 {cardinality="1"} ! 4-(phosphonooxy)-L-threonine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 [Term] id: UPa:UCR05688 name: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH namespace: reaction xref: KEGG:R05688 "KEGG reaction" xref: METACYC:DXPREDISOM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:13720 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC11434 {cardinality="1"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:UER00092 {cardinality="1", direction="RL", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6 [Term] id: UPa:UCR05692 name: GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + H(+) + NADPH namespace: reaction xref: KEGG:R05692 "KEGG reaction" xref: METACYC:1.1.1.271-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18888 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00325 {cardinality="1"} ! GDP-L-fucose relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01222 {cardinality="1"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:UER00191 {cardinality="1", direction="RL", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose: step 2/2 [Term] id: UPa:UCR05728 name: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+) namespace: reaction xref: KEGG:R05728 "KEGG reaction" xref: METACYC:1.14.13.68-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18404 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC04353 {cardinality="1"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC03742 {cardinality="1"} ! (S)-4-hydroxymandelonitrile relationship: part_of UPa:UER00745 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 2/3 [Term] id: UPa:UCR05732 name: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R05732 "KEGG reaction" xref: METACYC:1.14.13.71-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16652 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05176 {cardinality="1"} ! (S)-N-methylcoclaurine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC05202 {cardinality="1"} ! (S)-3'-hydroxy-N-methylcoclaurine relationship: part_of UPa:UER00443 {cardinality="1", direction="LR", order="1"} ! (S)-reticuline from (S)-norcoclaurine: step 3/4 [Term] id: UPa:UCR05765 name: geranyl diphosphate = (-)-alpha-pinene + diphosphate namespace: reaction xref: KEGG:R05765 "KEGG reaction" xref: METACYC:RXN-5106 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25491 "Rhea reaction" xref: RHEA:25665 "Rhea reaction" relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06308 {cardinality="1"} ! (-)-alpha-pinene relationship: part_of UPa:UER00927 {cardinality="1", direction="LR", order="1"} ! (-)-alpha-pinene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR05766 name: geranyl diphosphate = (-)-beta-pinene + diphosphate namespace: reaction xref: KEGG:R05766 "KEGG reaction" xref: METACYC:RXN-5107 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25499 "Rhea reaction" xref: RHEA:25669 "Rhea reaction" relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06307 {cardinality="1"} ! (-)-beta-pinene relationship: part_of UPa:UER00928 {cardinality="1", direction="LR", order="1"} ! (-)-beta-pinene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR05768 name: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + GDP namespace: reaction xref: KEGG:R05768 "KEGG reaction" xref: METACYC:2.4.1.217-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13540 "Rhea reaction" relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00197 {cardinality="1"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: part_of UPa:UER00192 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2 [Term] id: UPa:UCR05774 name: 3-sulfopyruvate = CO(2) + sulfoacetaldehyde namespace: reaction xref: KEGG:R05774 "KEGG reaction" xref: METACYC:R231-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20951 "Rhea reaction" relationship: has_input_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00593 {cardinality="1"} ! sulfoacetaldehyde relationship: part_of UPa:UER00472 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4 [Term] id: UPa:UCR05784 name: (4R)-limonene 1,2-epoxide + H(2)O = (1S,2S,4R)-limonene-1,2-diol namespace: reaction xref: KEGG:R05784 "KEGG reaction" xref: METACYC:RXN-9412 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10703 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide relationship: has_output_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol relationship: part_of UPa:UER00865 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 2/3 [Term] id: UPa:UCR05789 name: (2R)-O-phospho-3-sulfolactic acid + H(2)O = (R)-3-sulfolactate + phosphate namespace: reaction xref: KEGG:R05789 "KEGG reaction" xref: METACYC:R229-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23419 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate relationship: part_of UPa:UER00470 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 2/4 [Term] id: UPa:UCR05790 name: 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate namespace: reaction xref: KEGG:R05790 "KEGG reaction" xref: METACYC:3.1.3.70-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19312 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11516 {cardinality="1"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC11544 {cardinality="1"} ! 2-(alpha-D-mannosyl)-D-glycerate relationship: part_of UPa:UER00193 {cardinality="1", direction="LR", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2 [Term] id: UPa:UCR05794 name: CDP-diacylglycerol + choline = CMP + phosphatidylcholine namespace: reaction xref: KEGG:R05794 "KEGG reaction" xref: METACYC:2.7.8.24-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:14600 "Rhea reaction" relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00269 {cardinality="1"} ! CDP-diacylglycerol relationship: has_output_compound UPa:UPC00055 {cardinality="1"} ! CMP relationship: has_output_compound UPa:UPC00157 {cardinality="1"} ! phosphatidylcholine relationship: part_of UPa:UER00940 {cardinality="1", direction="LR", order="1"} ! phosphatidylcholine from choline: step 1/1 [Term] id: UPa:UCR05807 name: Co(2+) + sirohydrochlorin = 2 H(+) + cobalt-precorrin-2 namespace: reaction xref: KEGG:R05807 "KEGG reaction" xref: METACYC:4.99.1.3-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15896 "Rhea reaction" relationship: has_input_compound UPa:UPC00175 {cardinality="1"} ! Co(2+) relationship: has_input_compound UPa:UPC05778 {cardinality="1"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2 relationship: part_of UPa:UER00223 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10 [Term] id: UPa:UCR05808 name: S-adenosyl-L-methionine + cobalt-precorrin-2 = S-adenosyl-L-homocysteine + cobalt-factor III namespace: reaction xref: KEGG:R05808 "KEGG reaction" xref: METACYC:2.1.1.151-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18000 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11538 {cardinality="1"} ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC17401 {cardinality="1"} ! cobalt-factor III relationship: part_of UPa:UER00224 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 [Term] id: UPa:UCR05809 name: S-adenosyl-L-methionine + cobalt-precorrin 3 = S-adenosyl-L-homocysteine + cobalt-precorrin 4 namespace: reaction xref: KEGG:R05809 "KEGG reaction" xref: METACYC:RXN-8761 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26276 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11539 {cardinality="1"} ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4 relationship: part_of UPa:UER00225 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10 [Term] id: UPa:UCR05810 name: S-adenosyl-L-methionine + cobalt-precorrin 4 = S-adenosyl-L-homocysteine + cobalt-precorrin 5A namespace: reaction xref: KEGG:R05810 "KEGG reaction" xref: METACYC:RXN-8762 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26280 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11540 {cardinality="1"} ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC16242 {cardinality="1"} ! cobalt-precorrin 5A relationship: part_of UPa:UER00226 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10 [Term] id: UPa:UCR05812 name: H(+) + NADH + cobalt-precorrin-6A = NAD(+) + cobalt-precorrin-6B namespace: reaction xref: KEGG:R05812 "KEGG reaction" xref: METACYC:RXN-8765 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15628 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11542 {cardinality="1"} ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B relationship: part_of UPa:UER00228 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10 [Term] id: UPa:UCR05813 name: 2 S-adenosyl-L-methionine + cobalt-precorrin-6B = CO(2) + 2 S-adenosyl-L-homocysteine + cobalt-precorrin 8 namespace: reaction xref: KEGG:R05813 "KEGG reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11543 {cardinality="1"} ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8 relationship: part_of UPa:UER00229 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10 [Term] id: UPa:UCR05814 name: cobalt-precorrin 8 = cob(III)yrinic acid namespace: reaction xref: KEGG:R05814 "KEGG reaction" xref: METACYC:RXN-8768 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16212 "Rhea reaction" relationship: has_input_compound UPa:UPC11545 {cardinality="1"} ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid relationship: part_of UPa:UER00230 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10 [Term] id: UPa:UCR05815 name: 2 ATP + 2 H(2)O + 2 L-glutamine + cob(III)yrinic acid = 2 ADP + 2 L-glutamate + cob(II)yrinate a,c-diamide + 2 phosphate namespace: reaction xref: KEGG:R05815 "KEGG reaction" xref: METACYC:RXN-8769 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26292 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC05773 {cardinality="1"} ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC06504 {cardinality="1"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:UER00231 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10 [Term] id: UPa:UCR05820 name: D-sorbitol + protein N(pi)-phospho-L-histidine = D-sorbitol 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R05820 "KEGG reaction" xref: RHEA:42487 "Rhea reaction" relationship: has_input_compound UPa:UPC00794 {cardinality="1"} ! D-sorbitol relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: part_of UPa:UER00782 {cardinality="1", direction="LR", order="1"} ! D-sorbitol 6-phosphate from D-sorbitol: step 1/1 [Term] id: UPa:UCR05838 name: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + phosphate + pyridoxine 5'-phosphate namespace: reaction xref: KEGG:R05838 "KEGG reaction" xref: METACYC:PDXJ-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15268 "Rhea reaction" relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_input_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC00627 {cardinality="1"} ! pyridoxine 5'-phosphate relationship: part_of UPa:UER00313 {cardinality="1", direction="LR", order="1"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5 [Term] id: UPa:UCR05850 name: L-ribulose 5-phosphate = D-xylulose 5-phosphate namespace: reaction xref: KEGG:R05850 "KEGG reaction" xref: METACYC:RIBULPEPIM-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22371 "Rhea reaction" relationship: has_input_compound UPa:UPC01101 {cardinality="1"} ! L-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00231 {cardinality="1"} ! D-xylulose 5-phosphate relationship: part_of UPa:UER00380 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 4/4 relationship: part_of UPa:UER00567 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3 [Term] id: UPa:UCR05855 name: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+) namespace: reaction xref: KEGG:R05855 "KEGG reaction" xref: METACYC:1.14.13.73-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14136 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC09244 {cardinality="1"} ! tabersonine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine relationship: part_of UPa:UER00521 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 1/6 [Term] id: UPa:UCR05856 name: 16-methoxytabersonine + H(2)O = 3-hydroxy-16-methoxy-2,3-dihydrotabersonine namespace: reaction xref: KEGG:R05856 "KEGG reaction" xref: METACYC:RXN-8200 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42375 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine relationship: has_output_compound UPa:UPC04578 {cardinality="1"} ! 3-hydroxy-16-methoxy-2,3-dihydrotabersonine relationship: part_of UPa:UER00523 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 3/6 [Term] id: UPa:UCR05857 name: 2-oxoglutarate + O(2) + desacetoxyvindoline = CO(2) + deacetylvindoline + succinate namespace: reaction xref: KEGG:R05857 "KEGG reaction" xref: METACYC:1.14.11.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18976 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC02673 {cardinality="1"} ! desacetoxyvindoline relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1"} ! succinate relationship: has_output_compound UPa:UPC01091 {cardinality="1"} ! deacetylvindoline relationship: part_of UPa:UER00525 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 5/6 [Term] id: UPa:UCR05884 name: (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH = H(2)O + NADP(+) + isopentenyl diphosphate namespace: reaction xref: KEGG:R05884 "KEGG reaction" xref: METACYC:ISPH2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24491 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00129 {cardinality="1"} ! isopentenyl diphosphate relationship: part_of UPa:UER00097 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6 [Term] id: UPa:UCR05885 name: 16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R05885 "KEGG reaction" xref: METACYC:2.1.1.94-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20995 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11643 {cardinality="1"} ! 16-hydroxytabersonine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11675 {cardinality="1"} ! 16-methoxytabersonine relationship: part_of UPa:UER00522 {cardinality="1", direction="LR", order="1"} ! vindoline from tabersonine: step 2/6 [Term] id: UPa:UCR06117 name: (4S,6R)-trans-carveol + NAD(+) = (S)-carvone + H(+) + NADH namespace: reaction xref: KEGG:R06117 "KEGG reaction" xref: METACYC:RXN-9397 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14828 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone relationship: part_of UPa:UER00868 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 2/3 [Term] id: UPa:UCR06119 name: (4R)-limonene + H(+) + NADPH + O(2) = (4S,6R)-trans-carveol + H(2)O + NADP(+) namespace: reaction xref: KEGG:R06119 "KEGG reaction" xref: METACYC:RXN-10746 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18960 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11409 {cardinality="1"} ! (4S,6R)-trans-carveol relationship: part_of UPa:UER00867 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 1/3 [Term] id: UPa:UCR06120 name: geranyl diphosphate = (4R)-limonene + diphosphate namespace: reaction xref: KEGG:R06120 "KEGG reaction" xref: METACYC:4.2.3.20-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10943 "Rhea reaction" relationship: has_input_compound UPa:UPC00341 {cardinality="1"} ! geranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: part_of UPa:UER00926 {cardinality="1", direction="LR", order="1"} ! (4R)-limonene from geranyl diphosphate: step 1/1 [Term] id: UPa:UCR06171 name: L-allo-threonine = acetaldehyde + glycine namespace: reaction xref: KEGG:R06171 "KEGG reaction" xref: METACYC:LTAA-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:26212 "Rhea reaction" relationship: has_input_compound UPa:UPC05519 {cardinality="1"} ! L-allo-threonine relationship: has_output_compound UPa:UPC00037 {cardinality="1"} ! glycine relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: part_of UPa:UER00427 {cardinality="1", direction="LR", order="1"} ! glycine from L-allo-threonine: step 1/1 [Term] id: UPa:UCR06180 name: L-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH namespace: reaction xref: KEGG:R06180 "KEGG reaction" xref: METACYC:TARTRATE-DEHYDROGENASE-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15212 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00898 {cardinality="1"} ! L-tartrate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC03459 {cardinality="1"} ! 2-hydroxy-3-oxosuccinate relationship: part_of UPa:UER00800 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1 [Term] id: UPa:UCR06223 name: H(+) + NADPH + 2 farnesyl diphosphate = NADP(+) + 2 diphosphate + squalene namespace: reaction xref: KEGG:R06223 "KEGG reaction" xref: RHEA:32298 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00751 {cardinality="1"} ! squalene relationship: part_of UPa:UER00751 {cardinality="1", direction="LR", order="1"} ! lanosterol from farnesyl diphosphate: step 1/3 [Term] id: UPa:UCR06305 name: geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene namespace: reaction xref: KEGG:R06305 "KEGG reaction" xref: METACYC:4.2.3.17-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20915 "Rhea reaction" relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene relationship: part_of UPa:UER00806 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 1/2 [Term] id: UPa:UCR06306 name: O(2) + reduced acceptor + taxa-4,11-diene = H(2)O + acceptor + taxa-4(20),11-dien-5alpha-ol namespace: reaction xref: KEGG:R06306 "KEGG reaction" xref: METACYC:1.14.99.37-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14052 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC11894 {cardinality="1"} ! taxa-4,11-diene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: part_of UPa:UER00807 {cardinality="1", direction="LR", order="1"} ! taxa-4(20),11-dien-5alpha-ol from geranylgeranyl diphosphate: step 2/2 [Term] id: UPa:UCR06307 name: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate namespace: reaction xref: KEGG:R06307 "KEGG reaction" xref: METACYC:2.3.1.162-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:22031 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC11895 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-ol relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:UER00808 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 1/3 [Term] id: UPa:UCR06309 name: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+) namespace: reaction xref: KEGG:R06309 "KEGG reaction" xref: METACYC:1.14.13.76-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15244 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11896 {cardinality="1"} ! taxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11898 {cardinality="1"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: part_of UPa:UER00809 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 2/3 [Term] id: UPa:UCR06310 name: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA namespace: reaction xref: KEGG:R06310 "KEGG reaction" xref: METACYC:2.3.1.166-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18744 "Rhea reaction" relationship: has_input_compound UPa:UPC00512 {cardinality="1"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III relationship: part_of UPa:UER00810 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 1/2 [Term] id: UPa:UCR06311 name: 10-deacetylbaccatin III + acetyl-CoA = CoA + baccatin III namespace: reaction xref: KEGG:R06311 "KEGG reaction" xref: METACYC:2.3.1.167-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20140 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC11700 {cardinality="1"} ! 10-deacetylbaccatin III relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: part_of UPa:UER00811 {cardinality="1", direction="LR", order="1"} ! baccatin III from 10-deacetyl-2-debenzoylbaccatin III: step 2/2 [Term] id: UPa:UCR06372 name: (S)-carvone + reduced acceptor = (1R,4S)-isodihydrocarvone + acceptor namespace: reaction xref: KEGG:R06372 "KEGG reaction" xref: METACYC:RXN-9419 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:32430 "Rhea reaction" relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC11383 {cardinality="1"} ! (S)-carvone relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC11412 {cardinality="1"} ! (1R,4S)-isodihydrocarvone relationship: part_of UPa:UER00869 {cardinality="1", direction="LR", order="1"} ! (1R,4S)-isodihydrocarvone from (4R)-limonene: step 3/3 [Term] id: UPa:UCR06398 name: (4R)-limonene + H(+) + NADH + O(2) = (4R)-limonene 1,2-epoxide + H(2)O + NAD(+) namespace: reaction xref: KEGG:R06398 "KEGG reaction" xref: RHEA:26096 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC06099 {cardinality="1"} ! (4R)-limonene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC07271 {cardinality="1"} ! (4R)-limonene 1,2-epoxide relationship: part_of UPa:UER00864 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 1/3 [Term] id: UPa:UCR06399 name: (1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH namespace: reaction xref: KEGG:R06399 "KEGG reaction" xref: METACYC:RXN-9949 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:32386 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC07276 {cardinality="1"} ! (1S,2S,4R)-limonene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11937 {cardinality="1"} ! (1S,4R)-1-hydroxylimonen-2-one relationship: part_of UPa:UER00866 {cardinality="1", direction="LR", order="1"} ! (1S,4R)-1-hydroxylimonen-2-one from (4R)-limonene: step 3/3 [Term] id: UPa:UCR06558 name: GTP + adenosylcobinamide = GDP + adenosylcobinamide phosphate namespace: reaction xref: KEGG:R06558 "KEGG reaction" xref: METACYC:RXN-14063 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:15768 "Rhea reaction" relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC06508 {cardinality="1"} ! adenosylcobinamide relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC06509 {cardinality="1"} ! adenosylcobinamide phosphate relationship: part_of UPa:UER00954 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR06601 name: 5-hydroxyisouric acid + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid namespace: reaction xref: KEGG:R06601 "KEGG reaction" xref: METACYC:3.5.2.17-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23739 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC11821 {cardinality="1"} ! 5-hydroxyisouric acid relationship: has_output_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: part_of UPa:UER00651 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 2/3 [Term] id: UPa:UCR06604 name: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid = (S)-allantoin + CO(2) namespace: reaction xref: KEGG:R06604 "KEGG reaction" xref: METACYC:RXN-6201 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC12248 {cardinality="1"} ! 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC02350 {cardinality="1"} ! (S)-allantoin relationship: part_of UPa:UER00652 {cardinality="1", direction="LR", order="1"} ! (S)-allantoin from urate: step 3/3 [Term] id: UPa:UCR06782 name: 3-phenylpropanoate + H(+) + NADH + O(2) = NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol namespace: reaction xref: KEGG:R06782 "KEGG reaction" xref: METACYC:HCAMULTI-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20360 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05629 {cardinality="1"} ! 3-phenylpropanoate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: part_of UPa:UER00792 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 1/2 [Term] id: UPa:UCR06784 name: NAD(+) + cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH namespace: reaction xref: KEGG:R06784 "KEGG reaction" xref: METACYC:PHENPRODIOLDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25065 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC11588 {cardinality="1"} ! cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:UER00793 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-phenylpropanoate: step 2/2 [Term] id: UPa:UCR06786 name: 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+) namespace: reaction xref: KEGG:R06786 "KEGG reaction" xref: METACYC:MHPHYDROXY-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24788 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11457 {cardinality="1"} ! 3-(3-hydroxyphenyl)propanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC04044 {cardinality="1"} ! 3-(2,3-dihydroxyphenyl)propanoate relationship: part_of UPa:UER00791 {cardinality="1", direction="LR", order="1"} ! 3-(2,3-dihydroxyphenyl)propanoate from 3-(3-hydroxyphenyl)propanoate: step 1/1 [Term] id: UPa:UCR06836 name: ATP + D-ribose 1,5-bisphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ADP namespace: reaction xref: KEGG:R06836 "KEGG reaction" xref: METACYC:RXN0-1401 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:20112 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00119 {cardinality="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:UER00175 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3 [Term] id: UPa:UCR06837 name: alpha-D-ribose 1-phosphate = D-ribose 1,5-bisphosphate namespace: reaction xref: KEGG:R06837 "KEGG reaction" relationship: has_input_compound UPa:UPC00620 {cardinality="1"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC01151 {cardinality="1"} ! D-ribose 1,5-bisphosphate relationship: part_of UPa:UER00174 {cardinality="1", direction="LR", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3 [Term] id: UPa:UCR06868 name: N-methylethanolamine phosphate + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + phosphodimethylethanolamine namespace: reaction xref: KEGG:R06868 "KEGG reaction" xref: METACYC:RXN-5642 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25324 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01210 {cardinality="1"} ! N-methylethanolamine phosphate relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="2"} ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR06869 name: S-adenosyl-L-methionine + phosphodimethylethanolamine = S-adenosyl-L-homocysteine + phosphocholine namespace: reaction xref: KEGG:R06869 "KEGG reaction" xref: METACYC:RXN-5643 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25328 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC13482 {cardinality="1"} ! phosphodimethylethanolamine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00588 {cardinality="1"} ! phosphocholine relationship: part_of UPa:UER00738 {cardinality="1", direction="LR", order="3"} ! phosphocholine from phosphoethanolamine: step 1/1 [Term] id: UPa:UCR06895 name: 2 S-adenosyl-L-methionine + coproporphyrinogen-III = 2 5'-deoxyadenosine + 2 CO(2) + 2 L-methionine + protoporphyrinogen-IX namespace: reaction xref: KEGG:R06895 "KEGG reaction" xref: METACYC:HEMN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15428 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC03263 {cardinality="1"} ! coproporphyrinogen-III relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC01079 {cardinality="1"} ! protoporphyrinogen-IX relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: part_of UPa:UER00323 {cardinality="1", direction="LR", order="1"} ! protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1 [Term] id: UPa:UCR06897 name: 2-hydroxy-hept-2,4-diene-1,7-dioic acid + H(2)O = 2,4-dihydroxyhept-2-enedioic acid namespace: reaction xref: KEGG:R06897 "KEGG reaction" xref: RHEA:42075 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05600 {cardinality="1"} ! 2-hydroxy-hept-2,4-diene-1,7-dioic acid relationship: has_output_compound UPa:UPC06201 {cardinality="1"} ! 2,4-dihydroxyhept-2-enedioic acid relationship: part_of UPa:UER00421 {cardinality="1", direction="LR", order="1"} ! pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 6/7 [Term] id: UPa:UCR06974 name: ATP + N(1)-(5-phospho-D-ribosyl)glycinamide + formate = ADP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate namespace: reaction xref: KEGG:R06974 "KEGG reaction" xref: METACYC:GARTRANSFORMYL2-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24832 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_input_compound UPa:UPC03838 {cardinality="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04376 {cardinality="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:UER00127 {cardinality="1", direction="LR", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1 [Term] id: UPa:UCR06975 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate namespace: reaction xref: KEGG:R06975 "KEGG reaction" xref: METACYC:RXN-10066 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24839 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_input_compound UPa:UPC04677 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04734 {cardinality="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:UER00134 {cardinality="1", direction="LR", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1 [Term] id: UPa:UCR06977 name: L-aspartate 4-semialdehyde + L-glutamate = 2-oxoglutarate + L-2,4-diaminobutanoate namespace: reaction xref: KEGG:R06977 "KEGG reaction" xref: METACYC:R101-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:11163 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: part_of UPa:UER00121 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 1/3 relationship: part_of UPa:UER00731 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 1/2 [Term] id: UPa:UCR06978 name: L-2,4-diaminobutanoate + acetyl-CoA = CoA + N(4)-acetyl-L-2,4-diaminobutyric acid namespace: reaction xref: KEGG:R06978 "KEGG reaction" xref: METACYC:R102-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:16904 "Rhea reaction" relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_input_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: part_of UPa:UER00122 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 2/3 [Term] id: UPa:UCR06979 name: N(4)-acetyl-L-2,4-diaminobutyric acid = H(2)O + L-ectoine namespace: reaction xref: KEGG:R06979 "KEGG reaction" xref: METACYC:R103-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:17284 "Rhea reaction" relationship: has_input_compound UPa:UPC06442 {cardinality="1"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC06231 {cardinality="1"} ! L-ectoine relationship: part_of UPa:UER00123 {cardinality="1", direction="LR", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde: step 3/3 [Term] id: UPa:UCR06982 name: formaldehyde + glutathione = S-(hydroxymethyl)glutathione namespace: reaction xref: KEGG:R06982 "KEGG reaction" xref: METACYC:RXN-2961 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22491 "Rhea reaction" relationship: has_input_compound UPa:UPC00051 {cardinality="1"} ! glutathione relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_output_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: part_of UPa:UER00621 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (glutathione route): step 1/3 [Term] id: UPa:UCR06983 name: NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione namespace: reaction xref: KEGG:R06983 "KEGG reaction" xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:19988 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: part_of UPa:UER00971 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR06987 name: 2-oxobutanoate + CoA = formate + propanoyl-CoA namespace: reaction xref: KEGG:R06987 "KEGG reaction" xref: METACYC:KETOBUTFORMLY-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28057 "Rhea reaction" relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00109 {cardinality="1"} ! 2-oxobutanoate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00100 {cardinality="1"} ! propanoyl-CoA relationship: part_of UPa:UER00508 {cardinality="1", direction="LR", order="1"} ! propanoate from L-threonine: step 2/4 [Term] id: UPa:UCR06989 name: cis,cis-muconate = (S)-5-oxo-2,5-dihydro-2-furylacetic acid namespace: reaction xref: KEGG:R06989 "KEGG reaction" xref: RHEA:30034 "Rhea reaction" relationship: has_input_compound UPa:UPC02480 {cardinality="1"} ! cis,cis-muconate relationship: has_output_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: part_of UPa:UER00259 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3 [Term] id: UPa:UCR06990 name: (S)-5-oxo-2,5-dihydro-2-furylacetic acid = 5-oxo-4,5-dihydro-2-furylacetate namespace: reaction xref: KEGG:R06990 "KEGG reaction" xref: RHEA:12351 "Rhea reaction" relationship: has_input_compound UPa:UPC14610 {cardinality="1"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC03586 {cardinality="1"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:UER00260 {cardinality="1", direction="LR", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3 [Term] id: UPa:UCR07125 name: 3-dehydro-L-gulonate 6-phosphate + H(+) = CO(2) + L-xylulose 5-phosphate namespace: reaction xref: KEGG:R07125 "KEGG reaction" xref: METACYC:RXN0-705 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14356 "Rhea reaction" relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC14899 {cardinality="1"} ! 3-dehydro-L-gulonate 6-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC03291 {cardinality="1"} ! L-xylulose 5-phosphate relationship: part_of UPa:UER00378 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 2/4 [Term] id: UPa:UCR07133 name: D-sorbitol 6-phosphate + NAD(+) = D-fructose 6-phosphate + H(+) + NADH namespace: reaction xref: KEGG:R07133 "KEGG reaction" xref: METACYC:SORB6PDEHYDROG-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19840 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC01096 {cardinality="1"} ! D-sorbitol 6-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: part_of UPa:UER00783 {cardinality="1", direction="LR", order="1"} ! D-fructose 6-phosphate from D-sorbitol 6-phosphate: step 1/1 [Term] id: UPa:UCR07136 name: (R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH namespace: reaction xref: KEGG:R07136 "KEGG reaction" xref: METACYC:R230-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:15536 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC11537 {cardinality="1"} ! (R)-3-sulfolactate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05528 {cardinality="1"} ! 3-sulfopyruvate relationship: part_of UPa:UER00471 {cardinality="1", direction="LR", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4 [Term] id: UPa:UCR07140 name: NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione namespace: reaction xref: KEGG:R07140 "KEGG reaction" xref: METACYC:RXN-2962 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:19984 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC14180 {cardinality="1"} ! S-(hydroxymethyl)glutathione relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01031 {cardinality="1"} ! S-formylglutathione relationship: part_of UPa:UER00972 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07170 name: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2) namespace: reaction xref: KEGG:R07170 "KEGG reaction" xref: METACYC:R-6-HYDROXYNICOTINE-OXIDASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10015 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC03043 {cardinality="1"} ! (R)-6-hydroxynicotine relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: part_of UPa:UER00488 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 2/2 [Term] id: UPa:UCR07211 name: L-phenylalanine + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + L-tyrosine namespace: reaction xref: KEGG:R07211 "KEGG reaction" xref: METACYC:PHENYLALANINE-4-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20276 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00079 {cardinality="1"} ! L-phenylalanine relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:UER00337 {cardinality="1", direction="LR", order="1"} ! acetoacetate and fumarate from L-phenylalanine: step 1/6 [Term] id: UPa:UCR07213 name: L-tryptophan + O(2) + tetrahydrobiopterin = 4a-hydroxytetrahydrobiopterin + 5-hydroxy-L-tryptophan namespace: reaction xref: KEGG:R07213 "KEGG reaction" xref: METACYC:TRYPTOPHAN-5-MONOOXYGENASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16712 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00078 {cardinality="1"} ! L-tryptophan relationship: has_input_compound UPa:UPC00272 {cardinality="1"} ! tetrahydrobiopterin relationship: has_output_compound UPa:UPC00643 {cardinality="1"} ! 5-hydroxy-L-tryptophan relationship: has_output_compound UPa:UPC15522 {cardinality="1"} ! 4a-hydroxytetrahydrobiopterin relationship: part_of UPa:UER00799 {cardinality="1", direction="LR", order="1"} ! serotonin from L-tryptophan: step 1/2 [Term] id: UPa:UCR07214 name: 1-aminocyclopropanecarboxylate + L-ascorbate + O(2) = CO(2) + 2 H(2)O + L-dehydroascorbate + ethylene + hydrogen cyanide namespace: reaction xref: KEGG:R07214 "KEGG reaction" xref: METACYC:ETHYL-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:23643 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC01234 {cardinality="1"} ! 1-aminocyclopropanecarboxylate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00177 {cardinality="1"} ! hydrogen cyanide relationship: has_output_compound UPa:UPC05422 {cardinality="1"} ! L-dehydroascorbate relationship: has_output_compound UPa:UPC06547 {cardinality="1"} ! ethylene relationship: part_of UPa:UER00563 {cardinality="1", direction="LR", order="1"} ! ethylene from S-adenosyl-L-methionine: step 2/2 [Term] id: UPa:UCR07219 name: H(2)O + NADP(+) + dimethylallyl diphosphate = (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(+) + NADPH namespace: reaction xref: KEGG:R07219 "KEGG reaction" xref: METACYC:RXN0-884 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24828 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00235 {cardinality="1"} ! dimethylallyl diphosphate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:UER00105 {cardinality="1", direction="RL", order="1"} ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1 [Term] id: UPa:UCR07243 name: S-adenosyl-L-methionine + sarcosine = N,N-dimethylglycine + S-adenosyl-L-homocysteine namespace: reaction xref: KEGG:R07243 "KEGG reaction" xref: METACYC:RXN-9679 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15456 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00213 {cardinality="1"} ! sarcosine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: part_of UPa:UER00382 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 2/3 [Term] id: UPa:UCR07244 name: N,N-dimethylglycine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + betaine namespace: reaction xref: KEGG:R07244 "KEGG reaction" xref: METACYC:RXN-9680 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10075 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01026 {cardinality="1"} ! N,N-dimethylglycine relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UER00383 {cardinality="1", direction="LR", order="1"} ! betaine from glycine: step 3/3 [Term] id: UPa:UCR07262 name: 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O = 1,4-dihydroxy-2-naphthoate + CoA namespace: reaction xref: KEGG:R07262 "KEGG reaction" xref: METACYC:RXN-9311 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26312 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: part_of UPa:UER01033 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7 [Term] id: UPa:UCR07263 name: 2-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O namespace: reaction xref: KEGG:R07263 "KEGG reaction" xref: METACYC:NAPHTHOATE-SYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26565 "Rhea reaction" relationship: has_input_compound UPa:UPC03160 {cardinality="1"} ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC15547 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: part_of UPa:UER00167 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7 [Term] id: UPa:UCR07276 name: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate namespace: reaction xref: KEGG:R07276 "KEGG reaction" xref: METACYC:PREPHENATE-TRANSAMINE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22883 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00826 {cardinality="1"} ! L-arogenate relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00254 {cardinality="1"} ! prephenate relationship: part_of UPa:UER00343 {cardinality="1", direction="RL", order="1"} ! L-arogenate from prephenate (L-Glu route): step 1/1 [Term] id: UPa:UCR07280 name: 5-amino-6-(5-phosphoribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate namespace: reaction xref: KEGG:R07280 "KEGG reaction" xref: METACYC:RIBOPHOSPHAT-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25200 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04454 {cardinality="1"} ! 5-amino-6-(5-phosphoribitylamino)uracil relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC04732 {cardinality="1"} ! 5-amino-6-(D-ribitylamino)uracil relationship: part_of UPa:UER00403 {cardinality="1", direction="LR", order="1"} ! 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4 [Term] id: UPa:UCR07281 name: D-ribulose 5-phosphate = 2-hydroxy-3-oxobutyl phosphate + formate namespace: reaction xref: KEGG:R07281 "KEGG reaction" xref: METACYC:DIOHBUTANONEPSYN-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18460 "Rhea reaction" relationship: has_input_compound UPa:UPC00199 {cardinality="1"} ! D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC15556 {cardinality="1"} ! 2-hydroxy-3-oxobutyl phosphate relationship: part_of UPa:UER00399 {cardinality="1", direction="LR", order="1"} ! 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1 [Term] id: UPa:UCR07290 name: formyl-CoA + oxalate = formate + oxalyl-CoA namespace: reaction xref: KEGG:R07290 "KEGG reaction" xref: METACYC:RXN0-1382 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:16548 "Rhea reaction" relationship: has_input_compound UPa:UPC00209 {cardinality="1"} ! oxalate relationship: has_input_compound UPa:UPC00798 {cardinality="1"} ! formyl-CoA relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00313 {cardinality="1"} ! oxalyl-CoA relationship: part_of UPa:UER00598 {cardinality="1", direction="LR", order="1"} ! CO(2) and formate from oxalate: step 1/2 [Term] id: UPa:UCR07305 name: H(2)O + cyanurate = CO(2) + biuret namespace: reaction xref: KEGG:R07305 "KEGG reaction" xref: METACYC:R468-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14644 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC06554 {cardinality="1"} ! cyanurate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC06555 {cardinality="1"} ! biuret relationship: part_of UPa:UER00502 {cardinality="1", direction="LR", order="1"} ! biuret from cyanurate: step 1/1 [Term] id: UPa:UCR07307 name: 2 H(2)O + dCTP = NH(3) + dUMP + diphosphate namespace: reaction xref: KEGG:R07307 "KEGG reaction" xref: METACYC:3.5.4.30-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19208 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00458 {cardinality="1"} ! dCTP relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00365 {cardinality="1"} ! dUMP relationship: part_of UPa:UER00667 {cardinality="1", direction="LR", order="1"} ! dUMP from dCTP: step 1/1 [Term] id: UPa:UCR07320 name: violaxanthin = capsorubin namespace: reaction xref: KEGG:R07320 "KEGG reaction" xref: METACYC:RXN-7946 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:21755 "Rhea reaction" relationship: has_input_compound UPa:UPC08614 {cardinality="1"} ! violaxanthin relationship: has_output_compound UPa:UPC08585 {cardinality="1"} ! capsorubin relationship: part_of UPa:UER00775 {cardinality="1", direction="LR", order="1"} ! capsorubin from violaxanthin: step 1/1 [Term] id: UPa:UCR07321 name: antheraxanthin = capsanthin namespace: reaction xref: KEGG:R07321 "KEGG reaction" xref: METACYC:RXN-7947 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17376 "Rhea reaction" relationship: has_input_compound UPa:UPC08579 {cardinality="1"} ! antheraxanthin relationship: has_output_compound UPa:UPC08584 {cardinality="1"} ! capsanthin relationship: part_of UPa:UER00774 {cardinality="1", direction="LR", order="1"} ! capsanthin from antheraxanthin: step 1/1 [Term] id: UPa:UCR07324 name: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate namespace: reaction xref: KEGG:R07324 "KEGG reaction" xref: METACYC:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:10719 "Rhea reaction" relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC04006 {cardinality="1"} ! 1D-myo-inositol 3-phosphate relationship: part_of UPa:UER00787 {cardinality="1", direction="LR", order="1"} ! myo-inositol from D-glucose 6-phosphate: step 1/2 [Term] id: UPa:UCR07364 name: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate namespace: reaction xref: KEGG:R07364 "KEGG reaction" xref: METACYC:R147-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24507 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate relationship: part_of UPa:UER00878 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6 [Term] id: UPa:UCR07392 name: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O namespace: reaction xref: KEGG:R07392 "KEGG reaction" xref: METACYC:R145-RXN "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC04582 {cardinality="1"} ! S-methyl-5-thio-D-ribulose 1-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: part_of UPa:UER00875 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6 [Term] id: UPa:UCR07393 name: 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate namespace: reaction xref: KEGG:R07393 "KEGG reaction" xref: METACYC:R82-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:18772 "Rhea reaction" relationship: has_input_compound UPa:UPC15650 {cardinality="1"} ! 5-(methylthio)-2,3-dioxopentyl phosphate relationship: has_output_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: part_of UPa:UER00876 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6 [Term] id: UPa:UCR07394 name: 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate namespace: reaction xref: KEGG:R07394 "KEGG reaction" xref: METACYC:R83-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:14484 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15651 {cardinality="1"} ! 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC15606 {cardinality="1"} ! 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one relationship: part_of UPa:UER00877 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6 [Term] id: UPa:UCR07396 name: 4-methylthio-2-oxobutanoate + L-glutamate = 2-oxoglutarate + L-methionine namespace: reaction xref: KEGG:R07396 "KEGG reaction" xref: RHEA:25799 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC01180 {cardinality="1"} ! 4-methylthio-2-oxobutanoate relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: part_of UPa:UER00879 {cardinality="1", direction="LR", order="1"} ! L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6 [Term] id: UPa:UCR07399 name: H(2)O + acetyl-CoA + pyruvate = (R)-citramalate + CoA namespace: reaction xref: KEGG:R07399 "KEGG reaction" xref: METACYC:RXN-7743 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19048 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00024 {cardinality="1"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC02612 {cardinality="1"} ! (R)-citramalate relationship: part_of UPa:UER00066 {cardinality="1", direction="LR", order="1"} ! 2-oxobutanoate from pyruvate: step 1/3 [Term] id: UPa:UCR07403 name: H(+) + NADPH + O(2) + indole = H(2)O + NADP(+) + indolin-2-one namespace: reaction xref: KEGG:R07403 "KEGG reaction" xref: METACYC:RXN-6681 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31902 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00463 {cardinality="1"} ! indole relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one relationship: part_of UPa:UER00848 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 2/5 [Term] id: UPa:UCR07404 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate namespace: reaction xref: KEGG:R07404 "KEGG reaction" xref: METACYC:RXN0-742 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19320 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00288 {cardinality="1"} ! bicarbonate relationship: has_input_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00942 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2 [Term] id: UPa:UCR07405 name: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate namespace: reaction xref: KEGG:R07405 "KEGG reaction" xref: METACYC:RXN0-743 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13196 "Rhea reaction" relationship: has_input_compound UPa:UPC15667 {cardinality="1"} ! 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:UER00943 {cardinality="1", direction="LR", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2 [Term] id: UPa:UCR07406 name: 2-amino-3-oxo-4-phosphonooxybutyrate = 3-amino-2-oxopropyl phosphate + CO(2) namespace: reaction xref: KEGG:R07406 "KEGG reaction" xref: METACYC:RXN-8447 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25142 "Rhea reaction" relationship: has_input_compound UPa:UPC07335 {cardinality="1"} ! 2-amino-3-oxo-4-phosphonooxybutyrate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC11638 {cardinality="1"} ! 3-amino-2-oxopropyl phosphate relationship: part_of UPa:UER00312 {cardinality="1", direction="LR", order="2"} ! pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5 [Term] id: UPa:UCR07407 name: L-aspartate + NADP(+) = H(+) + NADPH + iminoaspartate namespace: reaction xref: KEGG:R07407 "KEGG reaction" xref: RHEA:42447 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00964 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07409 name: 2 H(+) + O(2) + choline + 2 reduced ferredoxin = 2 H(2)O + betaine aldehyde + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R07409 "KEGG reaction" xref: RHEA:17772 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00430 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (monooxygenase route): step 1/1 [Term] id: UPa:UCR07410 name: L-aspartate + NAD(+) = H(+) + NADH + iminoaspartate namespace: reaction xref: KEGG:R07410 "KEGG reaction" xref: RHEA:42443 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00049 {cardinality="1"} ! L-aspartate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05840 {cardinality="1"} ! iminoaspartate relationship: part_of UPa:UER00963 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07411 name: H(2)O + farnesyl diphosphate + protoheme = diphosphate + heme O namespace: reaction xref: KEGG:R07411 "KEGG reaction" xref: METACYC:HEMEOSYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:28073 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00032 {cardinality="1"} ! protoheme relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: part_of UPa:UER00712 {cardinality="1", direction="LR", order="1"} ! heme O from protoheme: step 1/1 [Term] id: UPa:UCR07412 name: heme O = heme A namespace: reaction xref: KEGG:R07412 "KEGG reaction" relationship: has_input_compound UPa:UPC15672 {cardinality="1"} ! heme O relationship: has_output_compound UPa:UPC15670 {cardinality="1"} ! heme A relationship: part_of UPa:UER00713 {cardinality="1", direction="LR", order="1"} ! heme A from heme O: step 1/1 [Term] id: UPa:UCR07414 name: ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + phosphate namespace: reaction xref: KEGG:R07414 "KEGG reaction" xref: METACYC:RXN0-3901 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:13636 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC00134 {cardinality="1"} ! putrescine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine relationship: part_of UPa:UER00880 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 1/4 [Term] id: UPa:UCR07415 name: H(2)O + O(2) + gamma-L-glutamylputrescine = H(2)O(2) + NH(3) + gamma-glutamyl-4-aminobutanal namespace: reaction xref: KEGG:R07415 "KEGG reaction" xref: RHEA:28417 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC15699 {cardinality="1"} ! gamma-L-glutamylputrescine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: part_of UPa:UER00881 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 2/4 [Term] id: UPa:UCR07417 name: H(2)O + NAD(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADH namespace: reaction xref: KEGG:R07417 "KEGG reaction" xref: RHEA:42343 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00989 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07418 name: H(2)O + NADP(+) + gamma-glutamyl-4-aminobutanal = 4-(L-gamma-glutamylamino)butanoic acid + H(+) + NADPH namespace: reaction xref: KEGG:R07418 "KEGG reaction" xref: METACYC:RXN0-3922 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28413 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15700 {cardinality="1"} ! gamma-glutamyl-4-aminobutanal relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: part_of UPa:UER00990 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR07419 name: 4-(L-gamma-glutamylamino)butanoic acid + H(2)O = 4-aminobutanoate + L-glutamate namespace: reaction xref: KEGG:R07419 "KEGG reaction" xref: METACYC:RXN0-3942 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:19740 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15767 {cardinality="1"} ! 4-(L-gamma-glutamylamino)butanoic acid relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC00334 {cardinality="1"} ! 4-aminobutanoate relationship: part_of UPa:UER00883 {cardinality="1", direction="LR", order="1"} ! 4-aminobutanoate from putrescine: step 4/4 [Term] id: UPa:UCR07421 name: H(+) + NADPH + O(2) + indolin-2-one = 3-hydroxyindolin-2-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07421 "KEGG reaction" xref: METACYC:RXN-6682 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31922 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC12312 {cardinality="1"} ! indolin-2-one relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one relationship: part_of UPa:UER00849 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 3/5 [Term] id: UPa:UCR07422 name: 3-hydroxyindolin-2-one + H(+) + NADPH + O(2) = 2-hydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07422 "KEGG reaction" xref: METACYC:RXN-6683 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31930 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC11130 {cardinality="1"} ! 3-hydroxyindolin-2-one relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:UER00850 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 4/5 [Term] id: UPa:UCR07423 name: 2-hydroxy-1,4-benzoxazin-3-one + H(+) + NADPH + O(2) = 2,4-dihydroxy-1,4-benzoxazin-3-one + H(2)O + NADP(+) namespace: reaction xref: KEGG:R07423 "KEGG reaction" xref: METACYC:RXN-6684 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31942 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC15769 {cardinality="1"} ! 2-hydroxy-1,4-benzoxazin-3-one relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC15770 {cardinality="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one relationship: part_of UPa:UER00851 {cardinality="1", direction="LR", order="1"} ! 2,4-dihydroxy-1,4-benzoxazin-3-one from indoleglycerol phosphate: step 5/5 [Term] id: UPa:UCR07476 name: (2R)-O-phospho-3-sulfolactic acid = phosphoenolpyruvate + sulfite namespace: reaction xref: KEGG:R07476 "KEGG reaction" xref: METACYC:4.4.1.19-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22787 "Rhea reaction" relationship: has_input_compound UPa:UPC11536 {cardinality="1"} ! (2R)-O-phospho-3-sulfolactic acid relationship: has_output_compound UPa:UPC00074 {cardinality="1"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00094 {cardinality="1"} ! sulfite relationship: part_of UPa:UER00469 {cardinality="1", direction="RL", order="1"} ! sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4 [Term] id: UPa:UCR07494 name: 4alpha-methylzymosterol-4-carboxylic acid + NADP(+) = 3-dehydro-4-methylzymosterol + CO(2) + H(+) + NADPH namespace: reaction xref: KEGG:R07494 "KEGG reaction" xref: METACYC:RXN66-313 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33450 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15808 {cardinality="1"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol relationship: part_of UPa:UER00757 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 4/6 [Term] id: UPa:UCR07495 name: 3-dehydro-4-methylzymosterol + H(+) + NADPH = 4-alpha-methylzymosterol + NADP(+) namespace: reaction xref: KEGG:R07495 "KEGG reaction" xref: METACYC:RXN66-314 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:36382 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC15816 {cardinality="1"} ! 3-dehydro-4-methylzymosterol relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol relationship: part_of UPa:UER00758 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 5/6 [Term] id: UPa:UCR07496 name: 4-alpha-methylzymosterol = zymosterol namespace: reaction xref: KEGG:R07496 "KEGG reaction" xref: RHEA:42459 "Rhea reaction" relationship: has_input_compound UPa:UPC05103 {cardinality="1"} ! 4-alpha-methylzymosterol relationship: has_output_compound UPa:UPC05437 {cardinality="1"} ! zymosterol relationship: part_of UPa:UER00759 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 6/6 [Term] id: UPa:UCR07497 name: fecosterol = episterol namespace: reaction xref: KEGG:R07497 "KEGG reaction" xref: METACYC:RXN3O-203 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33438 "Rhea reaction" relationship: has_input_compound UPa:UPC04525 {cardinality="1"} ! fecosterol relationship: has_output_compound UPa:UPC15777 {cardinality="1"} ! episterol relationship: part_of UPa:UER00761 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 2/5 [Term] id: UPa:UCR07505 name: NADP(+) + episterol = 5,7,24(28)-ergostatrienol + H(+) + NADPH namespace: reaction xref: KEGG:R07505 "KEGG reaction" xref: RHEA:33466 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15777 {cardinality="1"} ! episterol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC15778 {cardinality="1"} ! 5,7,24(28)-ergostatrienol relationship: part_of UPa:UER00762 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 3/5 [Term] id: UPa:UCR07506 name: 5,7,24(28)-ergostatrienol + NADP(+) = H(+) + NADPH + ergosta-5,7,22,24(28)-tetraen-3beta-ol namespace: reaction xref: KEGG:R07506 "KEGG reaction" xref: METACYC:RXN3O-227 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:33470 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC15778 {cardinality="1"} ! 5,7,24(28)-ergostatrienol relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC05440 {cardinality="1"} ! ergosta-5,7,22,24(28)-tetraen-3beta-ol relationship: part_of UPa:UER00763 {cardinality="1", direction="LR", order="1"} ! ergosterol from zymosterol: step 4/5 [Term] id: UPa:UCR07509 name: 14-demethyllanosterol + 3 H(+) + 3 NADPH + 3 O(2) = 4alpha-methylzymosterol-4-carboxylic acid + 4 H(2)O + 3 NADP(+) namespace: reaction xref: KEGG:R07509 "KEGG reaction" xref: RHEA:33446 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC05108 {cardinality="1"} ! 14-demethyllanosterol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC15808 {cardinality="1"} ! 4alpha-methylzymosterol-4-carboxylic acid relationship: part_of UPa:UER00756 {cardinality="1", direction="LR", order="1"} ! zymosterol from lanosterol: step 3/6 [Term] id: UPa:UCR07514 name: 6-hydroxypseudooxynicotine + H(2)O + acceptor = 2,6-dihydroxypseudooxynicotine + reduced acceptor namespace: reaction xref: KEGG:R07514 "KEGG reaction" xref: METACYC:R162-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34226 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC01297 {cardinality="1"} ! 6-hydroxypseudooxynicotine relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC15986 {cardinality="1"} ! 2,6-dihydroxypseudooxynicotine relationship: part_of UPa:UER00489 {cardinality="1", direction="LR", order="1"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 1/2 [Term] id: UPa:UCR07515 name: 2,6-dihydroxypseudooxynicotine + H(2)O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate namespace: reaction xref: KEGG:R07515 "KEGG reaction" xref: METACYC:R181-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:34170 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15986 {cardinality="1"} ! 2,6-dihydroxypseudooxynicotine relationship: has_output_compound UPa:UPC03056 {cardinality="1"} ! 2,6-dihydroxypyridine relationship: has_output_compound UPa:UPC15987 {cardinality="1"} ! 4-(methylamino)butanoate relationship: part_of UPa:UER00490 {cardinality="1", direction="LR", order="1"} ! 2,6-dihydroxypyridine and 4-(methylamino)butanoate from 6-hydroxypseudooxynicotine: step 2/2 [Term] id: UPa:UCR07613 name: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-tetrahydrodipicolinate + H(2)O + L-glutamate namespace: reaction xref: KEGG:R07613 "KEGG reaction" xref: METACYC:RXN-7737 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23991 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00666 {cardinality="1"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_output_compound UPa:UPC03972 {cardinality="1"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:UER00466 {cardinality="1", direction="RL", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1 [Term] id: UPa:UCR07629 name: 3-oxo-3-ureidopropanoic acid + H(2)O = malonate + urea namespace: reaction xref: KEGG:R07629 "KEGG reaction" xref: METACYC:3.5.1.95-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17364 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15607 {cardinality="1"} ! 3-oxo-3-ureidopropanoic acid relationship: has_output_compound UPa:UPC00086 {cardinality="1"} ! urea relationship: has_output_compound UPa:UPC00383 {cardinality="1"} ! malonate relationship: part_of UPa:UER00645 {cardinality="1", direction="LR", order="1"} ! malonate and urea from uracil: step 3/3 [Term] id: UPa:UCR07647 name: H(2)O + farnesyl diphosphate = diphosphate + germacradienol namespace: reaction xref: KEGG:R07647 "KEGG reaction" xref: METACYC:RXN-8648 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22439 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16143 {cardinality="1"} ! germacradienol relationship: part_of UPa:UER00583 {cardinality="1", direction="LR", order="1"} ! germacradienol from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR07648 name: farnesyl diphosphate = diphosphate + germacrene D namespace: reaction xref: KEGG:R07648 "KEGG reaction" xref: METACYC:RXN-8562 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12019 "Rhea reaction" relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16142 {cardinality="1"} ! germacrene D relationship: part_of UPa:UER00584 {cardinality="1", direction="LR", order="1"} ! germacrene D from farnesyl diphosphate: step 1/1 [Term] id: UPa:UCR07650 name: L-2,4-diaminobutanoate = 1,3-diaminopropane + CO(2) namespace: reaction xref: KEGG:R07650 "KEGG reaction" xref: METACYC:4.1.1.86-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15692 "Rhea reaction" relationship: has_input_compound UPa:UPC03283 {cardinality="1"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00986 {cardinality="1"} ! 1,3-diaminopropane relationship: part_of UPa:UER00732 {cardinality="1", direction="LR", order="1"} ! 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2 [Term] id: UPa:UCR07652 name: 2 farnesyl diphosphate = dehydrosqualene + 2 diphosphate namespace: reaction xref: KEGG:R07652 "KEGG reaction" xref: METACYC:RXN-12321 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:31550 "Rhea reaction" relationship: has_input_compound UPa:UPC00448 {cardinality="1"} ! farnesyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16144 {cardinality="1"} ! dehydrosqualene relationship: part_of UPa:UER00556 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 1/5 [Term] id: UPa:UCR07653 name: 3 FAD + dehydrosqualene = 4,4'-diaponeurosporene + 3 FADH2 namespace: reaction xref: KEGG:R07653 "KEGG reaction" relationship: has_input_compound UPa:UPC00016 {cardinality="1"} ! FAD relationship: has_input_compound UPa:UPC16144 {cardinality="1"} ! dehydrosqualene relationship: has_output_compound UPa:UPC01352 {cardinality="1"} ! FADH2 relationship: has_output_compound UPa:UPC16145 {cardinality="1"} ! 4,4'-diaponeurosporene relationship: part_of UPa:UER00557 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 2/5 [Term] id: UPa:UCR07654 name: 4,4'-diaponeurosporene + 3 O(2) + 3 reduced acceptor = 4,4'-diaponeurosporenic acid + 4 H(2)O + 3 acceptor namespace: reaction xref: KEGG:R07654 "KEGG reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC16145 {cardinality="1"} ! 4,4'-diaponeurosporene relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC16146 {cardinality="1"} ! 4,4'-diaponeurosporenic acid relationship: part_of UPa:UER00558 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 3/5 [Term] id: UPa:UCR07655 name: 4,4'-diaponeurosporenic acid = glycosyl-4,4'-diaponeurosporenic acid namespace: reaction xref: KEGG:R07655 "KEGG reaction" xref: METACYC:RXN-9308 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC16146 {cardinality="1"} ! 4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16147 {cardinality="1"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: part_of UPa:UER00559 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 4/5 [Term] id: UPa:UCR07656 name: glycosyl-4,4'-diaponeurosporenic acid = staphyloxanthin namespace: reaction xref: KEGG:R07656 "KEGG reaction" xref: METACYC:RXN-9309 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC16147 {cardinality="1"} ! glycosyl-4,4'-diaponeurosporenic acid relationship: has_output_compound UPa:UPC16148 {cardinality="1"} ! staphyloxanthin relationship: part_of UPa:UER00560 {cardinality="1", direction="LR", order="1"} ! staphyloxanthin from farnesyl diphosphate: step 5/5 [Term] id: UPa:UCR07658 name: NAD(+) + UDP-alpha-D-glucuronate = CO(2) + H(+) + NADH + UDP-beta-L-threo-pentopyranos-4-ulose namespace: reaction xref: KEGG:R07658 "KEGG reaction" xref: METACYC:RXN0-1861 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24705 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC16155 {cardinality="1"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: part_of UPa:UER00492 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 1/3 [Term] id: UPa:UCR07659 name: L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose = 2-oxoglutarate + UDP-4-amino-4-deoxy-L-arabinose namespace: reaction xref: KEGG:R07659 "KEGG reaction" xref: METACYC:RXN0-1863 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:24713 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC16155 {cardinality="1"} ! UDP-beta-L-threo-pentopyranos-4-ulose relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC16153 {cardinality="1"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: part_of UPa:UER00493 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3 [Term] id: UPa:UCR07660 name: 10-formyl-5,6,7,8-tetrahydrofolate + UDP-4-amino-4-deoxy-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose namespace: reaction xref: KEGG:R07660 "KEGG reaction" xref: METACYC:RXN0-1862 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24709 "Rhea reaction" relationship: has_input_compound UPa:UPC00234 {cardinality="1"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC16153 {cardinality="1"} ! UDP-4-amino-4-deoxy-L-arabinose relationship: has_output_compound UPa:UPC00101 {cardinality="1"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: part_of UPa:UER00494 {cardinality="1", direction="LR", order="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 3/3 [Term] id: UPa:UCR07661 name: UDP-4-deoxy-4-formamido-beta-L-arabinose + di-trans,poly-cis-undecaprenyl phosphate = 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + UDP namespace: reaction xref: KEGG:R07661 "KEGG reaction" xref: METACYC:RXN0-3521 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26360 "Rhea reaction" xref: RHEA:27725 "Rhea reaction" relationship: has_input_compound UPa:UPC16154 {cardinality="1"} ! UDP-4-deoxy-4-formamido-beta-L-arabinose relationship: has_input_compound UPa:UPC17556 {cardinality="1"} ! di-trans,poly-cis-undecaprenyl phosphate relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC16156 {cardinality="1"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: part_of UPa:UER00495 {cardinality="1", direction="LR", order="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2 [Term] id: UPa:UCR07662 name: 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate + formate namespace: reaction xref: KEGG:R07662 "KEGG reaction" xref: METACYC:RXN0-5409 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27737 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC16156 {cardinality="1"} ! 4-deoxy-4-formamido-alphaL-arabinose undecaprenyl phosphate relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC16157 {cardinality="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate relationship: part_of UPa:UER00496 {cardinality="1", direction="LR", order="1"} ! 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2 [Term] id: UPa:UCR07671 name: L-ascorbate + protein N(pi)-phospho-L-histidine = L-ascorbate 6-phosphate + protein-L-histidine namespace: reaction xref: KEGG:R07671 "KEGG reaction" xref: RHEA:42439 "Rhea reaction" relationship: has_input_compound UPa:UPC00072 {cardinality="1"} ! L-ascorbate relationship: has_input_compound UPa:UPC04261 {cardinality="1"} ! protein N(pi)-phospho-L-histidine relationship: has_output_compound UPa:UPC00615 {cardinality="1"} ! protein-L-histidine relationship: has_output_compound UPa:UPC16186 {cardinality="1"} ! L-ascorbate 6-phosphate relationship: part_of UPa:UER00377 {cardinality="1", direction="LR", order="1"} ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 [Term] id: UPa:UCR07672 name: GDP-alpha-D-mannose = GDP-L-gulose namespace: reaction xref: KEGG:R07672 "KEGG reaction" xref: METACYC:RXN-7771 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC15925 {cardinality="1"} ! GDP-L-gulose relationship: part_of UPa:UER00931 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 [Term] id: UPa:UCR07673 name: GDP-L-gulose = GDP-L-galactose namespace: reaction xref: KEGG:R07673 "KEGG reaction" xref: METACYC:RXN-7772 "MetaCyc REACTION" {source="MetaCyc"} relationship: has_input_compound UPa:UPC15925 {cardinality="1"} ! GDP-L-gulose relationship: has_output_compound UPa:UPC02280 {cardinality="1"} ! GDP-L-galactose relationship: part_of UPa:UER00931 {cardinality="1", direction="LR", order="2"} ! L-ascorbate from GDP-alpha-D-mannose: step 1/5 [Term] id: UPa:UCR07674 name: H(2)O + beta-L-galactose 1-phosphate = alpha-L-galactose + phosphate namespace: reaction xref: KEGG:R07674 "KEGG reaction" xref: METACYC:RXNQT-4142 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26352 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC15926 {cardinality="1"} ! beta-L-galactose 1-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC01825 {cardinality="1"} ! alpha-L-galactose relationship: part_of UPa:UER00933 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 3/5 [Term] id: UPa:UCR07675 name: NAD(+) + alpha-L-galactose = H(+) + L-Galactono-1,4-lactone + NADH namespace: reaction xref: KEGG:R07675 "KEGG reaction" xref: METACYC:RXN-1884 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:31562 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC01825 {cardinality="1"} ! alpha-L-galactose relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC01115 {cardinality="1"} ! L-Galactono-1,4-lactone relationship: part_of UPa:UER00934 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 4/5 [Term] id: UPa:UCR07677 name: H(2)O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate namespace: reaction xref: KEGG:R07677 "KEGG reaction" xref: METACYC:RXN0-5214 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28806 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC16186 {cardinality="1"} ! L-ascorbate 6-phosphate relationship: has_output_compound UPa:UPC14899 {cardinality="1"} ! 3-dehydro-L-gulonate 6-phosphate relationship: part_of UPa:UER00377 {cardinality="1", direction="LR", order="2"} ! D-xylulose 5-phosphate from L-ascorbate: step 1/4 [Term] id: UPa:UCR07678 name: GDP-L-galactose + phosphate = GDP + beta-L-galactose 1-phosphate namespace: reaction xref: KEGG:R07678 "KEGG reaction" xref: RHEA:27701 "Rhea reaction" relationship: has_input_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_input_compound UPa:UPC02280 {cardinality="1"} ! GDP-L-galactose relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC15926 {cardinality="1"} ! beta-L-galactose 1-phosphate relationship: part_of UPa:UER00932 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from GDP-alpha-D-mannose: step 2/5 [Term] id: UPa:UCR07766 name: apoprotein + octanoyl-[acyl-carrier-protein] = acyl-carrier protein + protein N(6)-(octanoyl)lysine namespace: reaction xref: KEGG:R07766 "KEGG reaction" xref: RHEA:17668 "Rhea reaction" relationship: has_input_compound UPa:UPC05752 {cardinality="1"} ! octanoyl-[acyl-carrier-protein] relationship: has_input_compound UPa:UPC16240 {cardinality="1"} ! apoprotein relationship: has_output_compound UPa:UPC00229 {cardinality="1"} ! acyl-carrier protein relationship: has_output_compound UPa:UPC16236 {cardinality="1"} ! protein N(6)-(octanoyl)lysine relationship: part_of UPa:UER00592 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2 [Term] id: UPa:UCR07767 name: 2 S-adenosyl-L-methionine + protein N(6)-(octanoyl)lysine + 2 sulfur donor = 2 5'-deoxyadenosine + 2 L-methionine + protein N(6)-(lipoyl)lysine namespace: reaction xref: KEGG:R07767 "KEGG reaction" xref: RHEA:16588 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16236 {cardinality="1"} ! protein N(6)-(octanoyl)lysine relationship: has_input_compound UPa:UPC17023 {cardinality="1"} ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1"} ! L-methionine relationship: has_output_compound UPa:UPC05198 {cardinality="1"} ! 5'-deoxyadenosine relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UER00593 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2 [Term] id: UPa:UCR07770 name: ATP + lipoate = diphosphate + lipoyl-AMP namespace: reaction xref: KEGG:R07770 "KEGG reaction" xref: METACYC:RXN-8654 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:12916 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00725 {cardinality="1"} ! lipoate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC16238 {cardinality="1"} ! lipoyl-AMP relationship: part_of UPa:UER00594 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from lipoate: step 1/2 [Term] id: UPa:UCR07771 name: apoprotein + lipoyl-AMP = AMP + protein N(6)-(lipoyl)lysine namespace: reaction xref: KEGG:R07771 "KEGG reaction" xref: METACYC:RXN-8655 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:20476 "Rhea reaction" relationship: has_input_compound UPa:UPC16238 {cardinality="1"} ! lipoyl-AMP relationship: has_input_compound UPa:UPC16240 {cardinality="1"} ! apoprotein relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC16237 {cardinality="1"} ! protein N(6)-(lipoyl)lysine relationship: part_of UPa:UER00595 {cardinality="1", direction="LR", order="1"} ! protein N(6)-(lipoyl)lysine from lipoate: step 2/2 [Term] id: UPa:UCR07772 name: H(2)O + cobalt-precorrin 5A = acetaldehyde + cobalt-precorrin 5B namespace: reaction xref: KEGG:R07772 "KEGG reaction" xref: METACYC:RXN-8763 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26284 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC16242 {cardinality="1"} ! cobalt-precorrin 5A relationship: has_output_compound UPa:UPC00084 {cardinality="1"} ! acetaldehyde relationship: has_output_compound UPa:UPC16243 {cardinality="1"} ! cobalt-precorrin 5B relationship: part_of UPa:UER00561 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 5/10 [Term] id: UPa:UCR07773 name: S-adenosyl-L-methionine + cobalt-precorrin 5B = S-adenosyl-L-homocysteine + cobalt-precorrin-6A namespace: reaction xref: KEGG:R07773 "KEGG reaction" xref: METACYC:RXN-8764 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26288 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16243 {cardinality="1"} ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11542 {cardinality="1"} ! cobalt-precorrin-6A relationship: part_of UPa:UER00227 {cardinality="1", direction="LR", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10 [Term] id: UPa:UCR07916 name: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate namespace: reaction xref: KEGG:R07916 "KEGG reaction" xref: METACYC:RXN1F-144 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:32454 "Rhea reaction" relationship: has_input_compound UPa:UPC00353 {cardinality="1"} ! geranylgeranyl diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC05413 {cardinality="1"} ! all-trans-phytoene relationship: part_of UPa:UER00773 {cardinality="1", direction="LR", order="1"} ! all-trans-phytoene from geranylgeranyl diphosphate: step 1/1 [Term] id: UPa:UCR07946 name: H(2)O + acceptor + nicotine = (R)-6-hydroxynicotine + reduced acceptor namespace: reaction xref: KEGG:R07946 "KEGG reaction" xref: METACYC:R161-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42355 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC16150 {cardinality="1"} ! nicotine relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_output_compound UPa:UPC03043 {cardinality="1"} ! (R)-6-hydroxynicotine relationship: part_of UPa:UER00918 {cardinality="1", direction="LR", order="1"} ! 6-hydroxypseudooxynicotine from nicotine (R-isomer route): step 1/2 [Term] id: UPa:UCR07984 name: 6-hydroxynicotinate + 2 H(2)O = 2-formylglutarate + NH(3) namespace: reaction xref: KEGG:R07984 "KEGG reaction" xref: METACYC:3.5.2.18-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:17212 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04226 {cardinality="1"} ! 6-hydroxynicotinate relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC16159 {cardinality="1"} ! 2-formylglutarate relationship: part_of UPa:UER01013 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 2/8 [Term] id: UPa:UCR07985 name: 2-formylglutarate + H(+) + NADH = 2-hydroxymethylglutarate + NAD(+) namespace: reaction xref: KEGG:R07985 "KEGG reaction" xref: METACYC:1.1.1.291-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:15508 "Rhea reaction" relationship: has_input_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC16159 {cardinality="1"} ! 2-formylglutarate relationship: has_output_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_output_compound UPa:UPC16390 {cardinality="1"} ! 2-hydroxymethylglutarate relationship: part_of UPa:UER01014 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 3/8 [Term] id: UPa:UCR07986 name: 2-hydroxymethylglutarate = 2-methyleneglutarate + H(2)O namespace: reaction xref: KEGG:R07986 "KEGG reaction" xref: METACYC:RXN-7640 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27585 "Rhea reaction" relationship: has_input_compound UPa:UPC16390 {cardinality="1"} ! 2-hydroxymethylglutarate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC02930 {cardinality="1"} ! 2-methyleneglutarate relationship: part_of UPa:UER01015 {cardinality="1", direction="LR", order="1"} ! propanoate and pyruvate from 6-hydroxynicotinate: step 4/8 [Term] id: UPa:UCR08058 name: 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylene-5,6,7,8-tetrahydromethanopterin + H(2)O namespace: reaction xref: KEGG:R08058 "KEGG reaction" xref: METACYC:RXN-2882 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24681 "Rhea reaction" relationship: has_input_compound UPa:UPC00067 {cardinality="1"} ! formaldehyde relationship: has_input_compound UPa:UPC01217 {cardinality="1"} ! 5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00701 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 1/5 [Term] id: UPa:UCR08059 name: 5,10-methylene-5,6,7,8-tetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH namespace: reaction xref: KEGG:R08059 "KEGG reaction" xref: METACYC:RXN-2883 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24685 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC04377 {cardinality="1"} ! 5,10-methylene-5,6,7,8-tetrahydromethanopterin relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC04330 {cardinality="1"} ! 5,10-methenyl-5,6,7,8-tetrahydromethanopterin relationship: part_of UPa:UER00702 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 2/5 [Term] id: UPa:UCR08060 name: H(2)O + N-formylmethanofuran = formate + methanofuran namespace: reaction xref: KEGG:R08060 "KEGG reaction" xref: METACYC:RXN-14028 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:24689 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC01001 {cardinality="1"} ! N-formylmethanofuran relationship: has_output_compound UPa:UPC00058 {cardinality="1"} ! formate relationship: has_output_compound UPa:UPC00862 {cardinality="1"} ! methanofuran relationship: part_of UPa:UER00705 {cardinality="1", direction="LR", order="1"} ! formate from formaldehyde (H(4)MPT route): step 5/5 [Term] id: UPa:UCR08124 name: ATP + fructoselysine = ADP + fructoselysine 6-phosphate namespace: reaction xref: KEGG:R08124 "KEGG reaction" xref: METACYC:RXN0-962 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:28381 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC16488 {cardinality="1"} ! fructoselysine relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC16489 {cardinality="1"} ! fructoselysine 6-phosphate relationship: part_of UPa:UER00769 {cardinality="1", direction="LR", order="1"} ! D-glucose 6-phosphate and lysine from fructoselysine: step 1/2 [Term] id: UPa:UCR08125 name: H(2)O + fructoselysine 6-phosphate = D-glucose 6-phosphate + L-lysine namespace: reaction xref: KEGG:R08125 "KEGG reaction" xref: METACYC:RXN0-963 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:28385 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC16489 {cardinality="1"} ! fructoselysine 6-phosphate relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: part_of UPa:UER00770 {cardinality="1", direction="LR", order="1"} ! D-glucose 6-phosphate and lysine from fructoselysine: step 2/2 [Term] id: UPa:UCR08165 name: 2-oxoglutarate + isochorismate = 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid + CO(2) namespace: reaction xref: KEGG:R08165 "KEGG reaction" xref: METACYC:2.5.1.64-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25596 "Rhea reaction" relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00885 {cardinality="1"} ! isochorismate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC16519 {cardinality="1"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: part_of UPa:UER00164 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7 [Term] id: UPa:UCR08166 name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid + pyruvate namespace: reaction xref: KEGG:R08166 "KEGG reaction" xref: METACYC:RXN-9310 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25600 "Rhea reaction" relationship: has_input_compound UPa:UPC16519 {cardinality="1"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC05817 {cardinality="1"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: part_of UPa:UER00900 {cardinality="1", direction="LR", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7 [Term] id: UPa:UCR08171 name: N-(3'R)-debenzoyltaxol + benzoyl-CoA = CoA + taxol namespace: reaction xref: KEGG:R08171 "KEGG reaction" xref: METACYC:RXN-8859 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33690 "Rhea reaction" relationship: has_input_compound UPa:UPC00512 {cardinality="1"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC16524 {cardinality="1"} ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC07394 {cardinality="1"} ! taxol relationship: part_of UPa:UER00053 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 3/3 [Term] id: UPa:UCR08172 name: baccatin III + beta-phenylalanoyl-CoA = CoA + N-(3'R)-debenzoyl-2'-deoxytaxol namespace: reaction xref: KEGG:R08172 "KEGG reaction" xref: METACYC:RXN-8857 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42491 "Rhea reaction" relationship: has_input_compound UPa:UPC11900 {cardinality="1"} ! baccatin III relationship: has_input_compound UPa:UPC16833 {cardinality="1"} ! beta-phenylalanoyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_output_compound UPa:UPC16523 {cardinality="1"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: part_of UPa:UER00812 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 1/3 [Term] id: UPa:UCR08173 name: N-(3'R)-debenzoyl-2'-deoxytaxol + O(2) + reduced acceptor = H(2)O + N-(3'R)-debenzoyltaxol + acceptor namespace: reaction xref: KEGG:R08173 "KEGG reaction" xref: RHEA:42495 "Rhea reaction" relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: has_input_compound UPa:UPC16523 {cardinality="1"} ! N-(3'R)-debenzoyl-2'-deoxytaxol relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_output_compound UPa:UPC16524 {cardinality="1"} ! N-(3'R)-debenzoyltaxol relationship: part_of UPa:UER00813 {cardinality="1", direction="LR", order="1"} ! taxol from baccatin III: step 2/3 [Term] id: UPa:UCR08193 name: N-acetyl-D-glucosamine 6-phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate namespace: reaction xref: KEGG:R08193 "KEGG reaction" xref: METACYC:PHOSACETYLGLUCOSAMINEMUT-RXN "MetaCyc REACTION" {source="Rhea"} xref: RHEA:23807 "Rhea reaction" relationship: has_input_compound UPa:UPC00357 {cardinality="1"} ! N-acetyl-D-glucosamine 6-phosphate relationship: has_output_compound UPa:UPC04501 {cardinality="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate relationship: part_of UPa:UER00530 {cardinality="1", direction="LR", order="1"} ! N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2 [Term] id: UPa:UCR08211 name: H(2)O + O(2) + betaine aldehyde = H(2)O(2) + betaine namespace: reaction xref: KEGG:R08211 "KEGG reaction" xref: RHEA:20372 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: has_output_compound UPa:UPC00027 {cardinality="1"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00719 {cardinality="1"} ! betaine relationship: part_of UPa:UER00384 {cardinality="1", direction="LR", order="2"} ! betaine from choline: step 1/1 [Term] id: UPa:UCR08218 name: ATP + L-serine + tRNA(Sec) = AMP + L-seryl-tRNA(Sec) + diphosphate namespace: reaction xref: KEGG:R08218 "KEGG reaction" xref: METACYC:RXN0-2161 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:42583 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00065 {cardinality="1"} ! L-serine relationship: has_input_compound UPa:UPC16636 {cardinality="1"} ! tRNA(Sec) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1"} ! AMP relationship: has_output_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: part_of UPa:UER00895 {cardinality="1", direction="LR", order="1"} ! L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1 [Term] id: UPa:UCR08219 name: L-seryl-tRNA(Sec) + selenophosphate = phosphate + selenocysteinyl-tRNA(Sec) namespace: reaction xref: KEGG:R08219 "KEGG reaction" xref: METACYC:2.9.1.1-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:22731 "Rhea reaction" relationship: has_input_compound UPa:UPC05172 {cardinality="1"} ! selenophosphate relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UER00896 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1 [Term] id: UPa:UCR08223 name: ATP + L-seryl-tRNA(Sec) = ADP + O-phosphoseryl-tRNA(Sec) namespace: reaction xref: KEGG:R08223 "KEGG reaction" xref: METACYC:RXN-10038 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25040 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC06481 {cardinality="1"} ! L-seryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC16638 {cardinality="1"} ! O-phosphoseryl-tRNA(Sec) relationship: part_of UPa:UER00897 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2 [Term] id: UPa:UCR08224 name: H(2)O + O-phosphoseryl-tRNA(Sec) + selenophosphate = 2 phosphate + selenocysteinyl-tRNA(Sec) namespace: reaction xref: KEGG:R08224 "KEGG reaction" xref: RHEA:25044 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC05172 {cardinality="1"} ! selenophosphate relationship: has_input_compound UPa:UPC16638 {cardinality="1"} ! O-phosphoseryl-tRNA(Sec) relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC06482 {cardinality="1"} ! selenocysteinyl-tRNA(Sec) relationship: part_of UPa:UER00898 {cardinality="1", direction="LR", order="1"} ! selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2 [Term] id: UPa:UCR08247 name: beta-D-ribopyranose = beta-D-ribofuranose namespace: reaction xref: KEGG:R08247 "KEGG reaction" xref: METACYC:RXN0-5304 "MetaCyc REACTION" {source="Rhea"} xref: RHEA:25435 "Rhea reaction" relationship: has_input_compound UPa:UPC08353 {cardinality="1"} ! beta-D-ribopyranose relationship: has_output_compound UPa:UPC16639 {cardinality="1"} ! beta-D-ribofuranose relationship: part_of UPa:UER00888 {cardinality="1", direction="LR", order="1"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 [Term] id: UPa:UCR08503 name: 5-deoxy-D-glucuronic acid = 2-deoxy-5-keto-D-gluconic acid namespace: reaction xref: KEGG:R08503 "KEGG reaction" xref: METACYC:RXN-14150 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:25843 "Rhea reaction" relationship: has_input_compound UPa:UPC16737 {cardinality="1"} ! 5-deoxy-D-glucuronic acid relationship: has_output_compound UPa:UPC06892 {cardinality="1"} ! 2-deoxy-5-keto-D-gluconic acid relationship: part_of UPa:UER00920 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 4/7 [Term] id: UPa:UCR08549 name: 2-oxoglutarate + CoA + NAD(+) = CO(2) + H(+) + NADH + succinyl-CoA namespace: reaction xref: KEGG:R08549 "KEGG reaction" xref: METACYC:2OXOGLUTARATEDEH-RXN "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:27789 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1"} ! CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00091 {cardinality="1"} ! succinyl-CoA relationship: part_of UPa:UER00997 {cardinality="1", direction="LR", order="1"} ! succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1 [Term] id: UPa:UCR08557 name: NAD(+) + choline = H(+) + NADH + betaine aldehyde namespace: reaction xref: KEGG:R08557 "KEGG reaction" xref: METACYC:RXN-6021 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:33054 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC00114 {cardinality="1"} ! choline relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC00576 {cardinality="1"} ! betaine aldehyde relationship: part_of UPa:UER00587 {cardinality="1", direction="LR", order="1"} ! betaine aldehyde from choline (dehydrogenase route): step 1/1 [Term] id: UPa:UCR08574 name: CTP + riboflavin = CDP + FMN namespace: reaction xref: KEGG:R08574 "KEGG reaction" xref: METACYC:RXN-9296 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:25024 "Rhea reaction" relationship: has_input_compound UPa:UPC00063 {cardinality="1"} ! CTP relationship: has_input_compound UPa:UPC00255 {cardinality="1"} ! riboflavin relationship: has_output_compound UPa:UPC00061 {cardinality="1"} ! FMN relationship: has_output_compound UPa:UPC00112 {cardinality="1"} ! CDP relationship: part_of UPa:UER00929 {cardinality="1", direction="LR", order="1"} ! FMN from riboflavin (CTP route): step 1/1 [Term] id: UPa:UCR08603 name: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O = 5-deoxy-D-glucuronic acid namespace: reaction xref: KEGG:R08603 "KEGG reaction" xref: RHEA:25839 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC04287 {cardinality="1"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC16737 {cardinality="1"} ! 5-deoxy-D-glucuronic acid relationship: part_of UPa:UER00145 {cardinality="1", direction="LR", order="1"} ! acetyl-CoA from myo-inositol: step 3/7 [Term] id: UPa:UCR08615 name: H(2)O + UDP-alpha-D-glucuronate = D-glucuronate + UDP namespace: reaction xref: KEGG:R08615 "KEGG reaction" xref: RHEA:26076 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00167 {cardinality="1"} ! UDP-alpha-D-glucuronate relationship: has_output_compound UPa:UPC00015 {cardinality="1"} ! UDP relationship: has_output_compound UPa:UPC00191 {cardinality="1"} ! D-glucuronate relationship: part_of UPa:UER00936 {cardinality="1", direction="LR", order="1"} ! L-ascorbate from UDP-alpha-D-glucuronate: step 1/4 [Term] id: UPa:UCR08617 name: D-glucose 6-phosphate = 2-deoxy-scyllo-inosose + phosphate namespace: reaction xref: KEGG:R08617 "KEGG reaction" xref: RHEA:33074 "Rhea reaction" relationship: has_input_compound UPa:UPC00092 {cardinality="1"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC17209 {cardinality="1"} ! 2-deoxy-scyllo-inosose relationship: part_of UPa:UER00921 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 1/4 [Term] id: UPa:UCR08656 name: 2 H(+) + L-tyrosine + 2 NADPH + 2 O(2) = (Z)-(4-hydroxyphenyl)acetaldehyde oxime + CO(2) + 3 H(2)O + 2 NADP(+) namespace: reaction xref: KEGG:R08656 "KEGG reaction" xref: RHEA:32314 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC00082 {cardinality="1"} ! L-tyrosine relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC04353 {cardinality="1"} ! (Z)-(4-hydroxyphenyl)acetaldehyde oxime relationship: part_of UPa:UER00744 {cardinality="1", direction="LR", order="1"} ! dhurrin from L-tyrosine: step 1/3 [Term] id: UPa:UCR08689 name: 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced ferredoxin = (2E)-4-hydroxy-3-methylbutenyl diphosphate + H(2)O + 2 oxidized ferredoxin namespace: reaction xref: KEGG:R08689 "KEGG reaction" xref: METACYC:RXN0-882 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26122 "Rhea reaction" relationship: has_input_compound UPa:UPC00138 {cardinality="1"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC11453 {cardinality="1"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC11811 {cardinality="1"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:UER00096 {cardinality="1", direction="LR", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6 [Term] id: UPa:UCR08716 name: cobalt-factor III = cobalt-precorrin 3 namespace: reaction xref: KEGG:R08716 "KEGG reaction" relationship: has_input_compound UPa:UPC17401 {cardinality="1"} ! cobalt-factor III relationship: has_output_compound UPa:UPC11539 {cardinality="1"} ! cobalt-precorrin 3 relationship: part_of UPa:UER00224 {cardinality="1", direction="LR", order="2"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 [Term] id: UPa:UCR08890 name: 2-deoxy-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate namespace: reaction xref: KEGG:R08890 "KEGG reaction" xref: RHEA:34150 "Rhea reaction" relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC17209 {cardinality="1"} ! 2-deoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: part_of UPa:UER00922 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4 [Term] id: UPa:UCR08891 name: 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate namespace: reaction xref: KEGG:R08891 "KEGG reaction" xref: RHEA:34154 "Rhea reaction" relationship: has_input_compound UPa:UPC00064 {cardinality="1"} ! L-glutamine relationship: has_input_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: has_output_compound UPa:UPC00940 {cardinality="1"} ! 2-oxoglutaramate relationship: has_output_compound UPa:UPC02627 {cardinality="1"} ! 2-deoxystreptamine relationship: part_of UPa:UER00924 {cardinality="1", direction="LR", order="1"} ! 2-deoxystreptamine from D-glucose 6-phosphate: step 4/4 [Term] id: UPa:UCR08892 name: 2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH namespace: reaction xref: KEGG:R08892 "KEGG reaction" xref: RHEA:33886 "Rhea reaction" relationship: has_input_compound UPa:UPC00003 {cardinality="1"} ! NAD(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00004 {cardinality="1"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER01031 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR08947 name: D-fructose 6-phosphate + GDP-alpha-D-mannose = GDP + beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate namespace: reaction xref: KEGG:R08947 "KEGG reaction" xref: METACYC:RXN-9935 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26042 "Rhea reaction" relationship: has_input_compound UPa:UPC00085 {cardinality="1"} ! D-fructose 6-phosphate relationship: has_input_compound UPa:UPC00096 {cardinality="1"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00035 {cardinality="1"} ! GDP relationship: has_output_compound UPa:UPC18050 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: part_of UPa:UER01009 {cardinality="1", direction="LR", order="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 1/2 [Term] id: UPa:UCR08982 name: H(2)O + beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate namespace: reaction xref: KEGG:R08982 "KEGG reaction" xref: METACYC:RXN-9936 "MetaCyc REACTION" {source="MetaCyc"} xref: RHEA:26022 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC18050 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside 6-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC18068 {cardinality="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside relationship: part_of UPa:UER01010 {cardinality="1", direction="LR", order="1"} ! beta-D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate and GDP-alpha-D-mannose: step 2/2 [Term] id: UPa:UCR09736 name: S-adenosyl-L-methionine + demethylmenaquinol = S-adenosyl-L-homocysteine + menaquinol namespace: reaction xref: KEGG:R09736 "KEGG reaction" xref: RHEA:42643 "Rhea reaction" relationship: has_input_compound UPa:UPC00019 {cardinality="1"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC19847 {cardinality="1"} ! demethylmenaquinol relationship: has_output_compound UPa:UPC00021 {cardinality="1"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05819 {cardinality="1"} ! menaquinol relationship: part_of UPa:UER00169 {cardinality="1", direction="LR", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2 [Term] id: UPa:UCR09770 name: ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-diphosphate namespace: reaction xref: KEGG:R09770 "KEGG reaction" xref: RHEA:27573 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC19879 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: part_of UPa:UER00606 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 1/3 [Term] id: UPa:UCR09771 name: D-glycero-alpha-D-manno-heptose 1,7-diphosphate + H(2)O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate namespace: reaction xref: KEGG:R09771 "KEGG reaction" xref: RHEA:28525 "Rhea reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC19879 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1,7-diphosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC19880 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: part_of UPa:UER00607 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 2/3 [Term] id: UPa:UCR09772 name: D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate namespace: reaction xref: KEGG:R09772 "KEGG reaction" xref: RHEA:27464 "Rhea reaction" relationship: has_input_compound UPa:UPC00044 {cardinality="1"} ! GTP relationship: has_input_compound UPa:UPC19880 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 1-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC19881 {cardinality="1"} ! GDP-D-glycero-alpha-D-manno-heptose relationship: part_of UPa:UER00608 {cardinality="1", direction="LR", order="1"} ! GDP-D-glycero-alpha-D-manno-heptose from D-glycero-alpha-D-manno-heptose 7-phosphate: step 3/3 [Term] id: UPa:UCR09775 name: ATP + L-alpha-aminoadipate + [LysW] = ADP + [LysW]-L-2-aminoadipate + phosphate namespace: reaction xref: KEGG:R09775 "KEGG reaction" xref: RHEA:41943 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC00956 {cardinality="1"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC19885 {cardinality="1"} ! [LysW] relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC19886 {cardinality="1"} ! [LysW]-L-2-aminoadipate relationship: part_of UPa:UER00035 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5 [Term] id: UPa:UCR09776 name: ATP + [LysW]-L-2-aminoadipate = ADP + [LysW]-L-2-aminoadipyl 6-phosphate namespace: reaction xref: KEGG:R09776 "KEGG reaction" xref: RHEA:41947 "Rhea reaction" relationship: has_input_compound UPa:UPC00002 {cardinality="1"} ! ATP relationship: has_input_compound UPa:UPC19886 {cardinality="1"} ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC00008 {cardinality="1"} ! ADP relationship: has_output_compound UPa:UPC19887 {cardinality="1"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: part_of UPa:UER00036 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5 [Term] id: UPa:UCR09777 name: H(+) + NADPH + [LysW]-L-2-aminoadipyl 6-phosphate = NADP(+) + [LysW]-L-2-aminoadipate 6-semialdehyde + phosphate namespace: reaction xref: KEGG:R09777 "KEGG reaction" xref: RHEA:41951 "Rhea reaction" relationship: has_input_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_input_compound UPa:UPC19887 {cardinality="1"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1"} ! phosphate relationship: has_output_compound UPa:UPC19888 {cardinality="1"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: part_of UPa:UER00037 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5 [Term] id: UPa:UCR09778 name: L-glutamate + [LysW]-L-2-aminoadipate 6-semialdehyde = 2-oxoglutarate + [LysW]-L-lysine namespace: reaction xref: KEGG:R09778 "KEGG reaction" xref: METACYC:RXN-5184 "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:41955 "Rhea reaction" relationship: has_input_compound UPa:UPC00025 {cardinality="1"} ! L-glutamate relationship: has_input_compound UPa:UPC19888 {cardinality="1"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC19889 {cardinality="1"} ! [LysW]-L-lysine relationship: part_of UPa:UER00038 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5 [Term] id: UPa:UCR09779 name: H(2)O + [LysW]-L-lysine = L-lysine + [LysW] namespace: reaction xref: KEGG:R09779 "KEGG reaction" relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC19889 {cardinality="1"} ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_output_compound UPa:UPC19885 {cardinality="1"} ! [LysW] relationship: part_of UPa:UER00039 {cardinality="1", direction="LR", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5 [Term] id: UPa:UCR10130 name: 2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH namespace: reaction xref: KEGG:R10130 "KEGG reaction" xref: RHEA:33882 "Rhea reaction" relationship: has_input_compound UPa:UPC00006 {cardinality="1"} ! NADP(+) relationship: has_input_compound UPa:UPC17580 {cardinality="1"} ! 2-deoxy-scyllo-inosamine relationship: has_output_compound UPa:UPC00005 {cardinality="1"} ! NADPH relationship: has_output_compound UPa:UPC00080 {cardinality="1"} ! H(+) relationship: has_output_compound UPa:UPC17581 {cardinality="1"} ! 3-amino-2,3-dideoxy-scyllo-inosose relationship: part_of UPa:UER01032 {cardinality="1", direction="LR", order="1"} ! None [Term] id: UPa:UCR10147 name: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(2)O namespace: reaction xref: KEGG:R10147 "KEGG reaction" xref: METACYC:DIHYDRODIPICSYN-RXN "MetaCyc REACTION" {source="Rhea", source="MetaCyc"} xref: RHEA:34174 "Rhea reaction" relationship: has_input_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_input_compound UPa:UPC00441 {cardinality="1"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_output_compound UPa:UPC20258 {cardinality="1"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:UER00017 {cardinality="1", direction="LR", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate: step 3/4 [Term] id: UPa:UCR10757 name: 1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate = CO(2) + demethylmenaquinol + diphosphate namespace: reaction xref: KEGG:R10757 "KEGG reaction" relationship: has_input_compound UPa:UPC03657 {cardinality="1"} ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC05847 {cardinality="1"} ! all-trans-polyprenyl diphosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1"} ! CO(2) relationship: has_output_compound UPa:UPC00013 {cardinality="1"} ! diphosphate relationship: has_output_compound UPa:UPC19847 {cardinality="1"} ! demethylmenaquinol relationship: part_of UPa:UER00168 {cardinality="1", direction="LR", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2 [Term] id: UPa:UCY00012 name: 1-deoxy-D-xylulose 5-phosphate = 4-methyl-5-(2-phosphoethyl)-thiazole namespace: reaction relationship: has_input_compound UPa:UPC11437 {cardinality="1"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC04327 {cardinality="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:UER00140 {cardinality="1", direction="LR", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate: step 1/1 [Term] id: UPa:UCY00016 name: D-alanine + H(2)O + acceptor = NH(3) + pyruvate + reduced acceptor namespace: reaction relationship: has_input_compound UPa:UPC00001 {cardinality="1"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1"} ! acceptor relationship: has_input_compound UPa:UPC00133 {cardinality="1"} ! D-alanine relationship: has_output_compound UPa:UPC00014 {cardinality="1"} ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1"} ! pyruvate relationship: has_output_compound UPa:UPC00030 {cardinality="1"} ! reduced acceptor relationship: part_of UPa:UER00498 {cardinality="1", direction="LR", order="1"} ! NH(3) and pyruvate from D-alanine: step 1/1 [Term] id: UPa:UCY00018 name: 2 sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate namespace: reaction relationship: has_input_compound UPa:UPC05382 {cardinality="1"} ! sedoheptulose 7-phosphate relationship: has_output_compound UPa:UPC07836 {cardinality="1"} ! D-glycero-beta-D-manno-heptose 7-phosphate relationship: has_output_compound UPa:UPC19878 {cardinality="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate relationship: part_of UPa:UER00436 {cardinality="1", direction="LR", order="1"} ! D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1 [Term] id: UPa:UCY00032 name: pectate = 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid + pectate(n-2) namespace: reaction relationship: has_input_compound UPa:UPC00470 {cardinality="1"} ! pectate relationship: has_output_compound UPa:UPC06118 {cardinality="1"} ! 4-(4-deoxy-alpha-D-gluc-4-enosyluronic acid)-D-galacturonic acid relationship: has_output_compound UPa:UPX00024 {cardinality="1"} ! pectate(n-2) relationship: part_of UPa:UER00824 {cardinality="1", direction="LR", order="1"} ! 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5 [Term] id: UPa:UCY00036 name: beta-D-ribofuranose = D-ribose namespace: reaction relationship: has_input_compound UPa:UPC16639 {cardinality="1"} ! beta-D-ribofuranose relationship: has_output_compound UPa:UPC00121 {cardinality="1"} ! D-ribose relationship: part_of UPa:UER00888 {cardinality="1", direction="LR", order="2"} ! D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2 [Term] id: UPa:UCY00044 name: 8-amino-7-oxononanoate + L-lysine = 7,8-diaminononanoate + L-2-aminoadipate 6-semialdahyde namespace: reaction relationship: has_input_compound UPa:UPC00047 {cardinality="1"} ! L-lysine relationship: has_input_compound UPa:UPC01092 {cardinality="1"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04076 {cardinality="1"} ! L-2-aminoadipate 6-semialdahyde relationship: part_of UPa:UER00944 {cardinality="1", direction="LR", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (Lys route): step 1/1 [Term] id: UPa:UCY00047 name: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III namespace: reaction relationship: has_input_compound UPa:UPC11898 {cardinality="1"} ! 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate relationship: has_output_compound UPa:UPC11899 {cardinality="1"} ! 10-deacetyl-2-debenzoylbaccatin III relationship: part_of UPa:UER00817 {cardinality="1", direction="LR", order="1"} ! 10-deacetyl-2-debenzoylbaccatin III from taxa-4(20),11-dien-5alpha-ol: step 3/3 [Term] id: UPa:UCY00048 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine = 5-amino-1-(5-phospho-D-ribosyl)imidazole namespace: reaction relationship: has_input_compound UPa:UPC01279 {cardinality="1"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC03373 {cardinality="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:UER00136 {cardinality="1", direction="RL", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 1/3 [Term] id: UPa:UER00000 name: enzymatic-reaction namespace: enzymatic_reaction def: "An enzymatic-reaction involved in a UniPathway pathway. An enzymatic-reaction is a set of alternate sequence-reactions, catalyzed by the same enzyme. It aims at representing ambiguity on co-substrate/co-product (e.g NAD(P)H." [] [Term] id: UPa:UER00002 name: beta-alanine from L-aspartate: step 1/1 namespace: enzymatic_reaction def: "1 L-aspartate => 1 CO(2) + 1 beta-alanine." [] xref: EC:4.1.1.11 xref: GO:0004068 "molecular_function:aspartate 1-decarboxylase activity" relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00099 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-alanine relationship: part_of UPa:ULS00002 {cardinality="1", order="1"} ! beta-alanine from L-aspartate [Term] id: UPa:UER00003 name: (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 5,10-methylene-THF + 1 H(2)O => 1 2-dehydropantoate + 1 5,6,7,8-tetrahydrofolate." [] xref: EC:2.1.2.11 xref: GO:0003864 "molecular_function:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_input_compound UPa:UPC00143 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,10-methylene-THF relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00966 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydropantoate relationship: part_of UPa:ULS00003 {cardinality="1", order="1"} ! (R)-pantoate from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00004 name: (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2 namespace: enzymatic_reaction def: "1 2-dehydropantoate + 1 H(+) + 1 NADPH => 1 (R)-pantoate + 1 NADP(+)." [] xref: EC:1.1.1.169 xref: GO:0008677 "molecular_function:2-dehydropantoate 2-reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00966 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-dehydropantoate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00522 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantoate relationship: part_of UPa:ULS00003 {cardinality="1", order="2"} ! (R)-pantoate from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00005 name: (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1 namespace: enzymatic_reaction def: "1 (R)-pantoate + 1 ATP + 1 beta-alanine => 1 (R)-pantothenate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.2.1 xref: GO:0004592 "molecular_function:pantoate-beta-alanine ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00099 {cardinality="1", is_alternate="False", is_primary="True"} ! beta-alanine relationship: has_input_compound UPa:UPC00522 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantoate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00864 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-pantothenate relationship: part_of UPa:ULS00004 {cardinality="1", order="1"} ! (R)-pantothenate from (R)-pantoate and beta-alanine [Term] id: UPa:UER00006 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 ATP => 1 1-(5-phospho-D-ribosyl)-ATP + 1 diphosphate." [] xref: EC:2.4.2.17 xref: GO:0003879 "molecular_function:ATP phosphoribosyltransferase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC02739 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: part_of UPa:ULS00005 {cardinality="1", order="1"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00007 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9 namespace: enzymatic_reaction def: "1 1-(5-phospho-D-ribosyl)-ATP + 1 H(2)O => 1 1-(5-phosphoribosyl)-5'-AMP + 1 diphosphate." [] xref: EC:3.6.1.31 xref: GO:0004636 "molecular_function:phosphoribosyl-ATP diphosphatase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02739 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phospho-D-ribosyl)-ATP relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC02741 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: part_of UPa:ULS00005 {cardinality="1", order="2"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00008 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9 namespace: enzymatic_reaction def: "1 1-(5-phosphoribosyl)-5'-AMP + 1 H(2)O => 1 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide." [] xref: EC:3.5.4.19 xref: GO:0004635 "molecular_function:phosphoribosyl-AMP cyclohydrolase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02741 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(5-phosphoribosyl)-5'-AMP relationship: has_output_compound UPa:UPC04896 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: part_of UPa:ULS00005 {cardinality="1", order="3"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00009 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 namespace: enzymatic_reaction def: "1 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide => 1 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide." [] xref: EC:5.3.1.16 xref: GO:0003949 "molecular_function:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity" relationship: has_input_compound UPa:UPC04896 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide relationship: has_output_compound UPa:UPC04916 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00005 {cardinality="1", order="4"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00010 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9 namespace: enzymatic_reaction def: "1 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + 1 L-glutamine => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 1 L-glutamate." [] xref: EC:2.4.2 xref: EC:4.1.3 xref: GO:0000107 "molecular_function:imidazoleglycerol-phosphate synthase activity" xref: GO:0016763 "molecular_function:transferase activity, transferring pentosyl groups" xref: GO:0016833 "molecular_function:oxo-acid-lyase activity" xref: GO:0018071 "molecular_function:NAD(P)-cysteine ADP-ribosyltransferase activity" xref: GO:0018121 "molecular_function:NAD(P)-asparagine ADP-ribosyltransferase activity" xref: GO:0018127 "molecular_function:NAD(P)-serine ADP-ribosyltransferase activity" xref: GO:0034815 "molecular_function:cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity" xref: GO:0034830 "molecular_function:(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity" xref: GO:0034905 "molecular_function:5-chloro-4-hydroxy-2-oxopentanate aldolase activity" xref: GO:0043867 "molecular_function:7-cyano-7-deazaguanine tRNA-ribosyltransferase activity" xref: GO:0043904 "molecular_function:isochorismate pyruvate lyase activity" xref: GO:0043959 "molecular_function:L-erythro-3-methylmalyl-CoA lyase activity" xref: GO:0044101 "molecular_function:(R)-citramalyl-CoA lyase activity" xref: GO:0044102 "molecular_function:purine deoxyribosyltransferase activity" relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC04916 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC04666 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00005 {cardinality="1", order="5"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00011 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9 namespace: enzymatic_reaction def: "1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 1 H(2)O + 1 imidazole-acetol phosphate." [] xref: EC:4.2.1.19 xref: GO:0004424 "molecular_function:imidazoleglycerol-phosphate dehydratase activity" relationship: has_input_compound UPa:UPC04666 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01267 {cardinality="1", is_alternate="False", is_primary="True"} ! imidazole-acetol phosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="6"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00012 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9 namespace: enzymatic_reaction def: "1 L-glutamate + 1 imidazole-acetol phosphate => 1 2-oxoglutarate + 1 L-histidinol phosphate." [] xref: EC:2.6.1.9 xref: GO:0004400 "molecular_function:histidinol-phosphate transaminase activity" xref: GO:0080130 "molecular_function:L-phenylalanine:2-oxoglutarate aminotransferase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC01267 {cardinality="1", is_alternate="False", is_primary="True"} ! imidazole-acetol phosphate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01100 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol phosphate relationship: part_of UPa:ULS00005 {cardinality="1", order="7"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00013 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-histidinol phosphate => 1 L-histidinol + 1 phosphate." [] xref: EC:3.1.3.15 xref: GO:0004401 "molecular_function:histidinol-phosphatase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01100 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00860 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol relationship: part_of UPa:ULS00005 {cardinality="1", order="8"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00014 name: L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-histidinol + 2 NAD(+) => 2 H(+) + 1 L-histidine + 2 NADH." [] xref: EC:1.1.1.23 xref: GO:0004399 "molecular_function:histidinol dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00860 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidinol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00135 {cardinality="1", is_alternate="False", is_primary="True"} ! L-histidine relationship: part_of UPa:ULS00005 {cardinality="1", order="9"} ! L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00015 name: (S)-tetrahydrodipicolinate from L-aspartate: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP." [] xref: EC:2.7.2.4 xref: GO:0004072 "molecular_function:aspartate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: part_of UPa:ULS00006 {cardinality="1", order="1"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00016 name: (S)-tetrahydrodipicolinate from L-aspartate: step 2/4 namespace: enzymatic_reaction def: "1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.11 xref: GO:0004073 "molecular_function:aspartate-semialdehyde dehydrogenase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03082 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-phospho-L-aspartate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: part_of UPa:ULS00006 {cardinality="1", order="2"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00017 name: (S)-tetrahydrodipicolinate from L-aspartate: step 3/4 namespace: enzymatic_reaction def: "1 L-aspartate 4-semialdehyde + 1 pyruvate => 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(2)O." [] xref: EC:4.3.3.7 xref: GO:0008840 "molecular_function:4-hydroxy-tetrahydrodipicolinate synthase" relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: part_of UPa:ULS00006 {cardinality="1", order="3"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00018 name: (S)-tetrahydrodipicolinate from L-aspartate: step 4/4 namespace: enzymatic_reaction def: "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + [NADH or NADPH] => (S)-tetrahydrodipicolinate + H(2)O + [NAD(+) or NADP(+)]." [] xref: EC:1.17.1.8 xref: GO:0008839 "molecular_function:4-hydroxy-tetrahydrodipicolinate reductase" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC20258 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: part_of UPa:ULS00006 {cardinality="1", order="4"} ! (S)-tetrahydrodipicolinate from L-aspartate [Term] id: UPa:UER00019 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 succinyl-CoA => 1 CoA + 1 L-2-succinylamino-6-oxopimelate." [] xref: EC:2.3.1.117 xref: GO:0008666 "molecular_function:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC04462 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-succinylamino-6-oxopimelate relationship: part_of UPa:ULS00007 {cardinality="1", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00020 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3 namespace: enzymatic_reaction def: "1 L-2-succinylamino-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-succinyl-LL-2,6-diaminopimelate." [] xref: EC:2.6.1.17 xref: GO:0009016 "molecular_function:succinyldiaminopimelate transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC04462 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-succinylamino-6-oxopimelate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC04421 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-LL-2,6-diaminopimelate relationship: part_of UPa:ULS00007 {cardinality="1", order="2"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00021 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-succinyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 succinate." [] xref: EC:3.5.1.18 xref: GO:0009014 "molecular_function:succinyl-diaminopimelate desuccinylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04421 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: part_of UPa:ULS00007 {cardinality="1", order="3"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) [Term] id: UPa:UER00022 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 acetyl-CoA => 1 (S)-2-acetamido-6-oxopimelate + 1 CoA." [] xref: EC:2.3.1.89 xref: GO:0047200 "molecular_function:tetrahydrodipicolinate N-acetyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC05539 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetamido-6-oxopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="1"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00023 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3 namespace: enzymatic_reaction def: "1 (S)-2-acetamido-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-acetyl-LL-2,6-diaminopimelate." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC05539 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetamido-6-oxopimelate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC04390 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-LL-2,6-diaminopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="2"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00024 name: LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-acetyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 acetate." [] xref: EC:3.5.1.47 xref: GO:0050118 "molecular_function:N-acetyldiaminopimelate deacetylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04390 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: part_of UPa:ULS00008 {cardinality="1", order="3"} ! LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) [Term] id: UPa:UER00025 name: DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1 namespace: enzymatic_reaction def: "1 LL-2,6-diaminopimelate => 1 DL-2,6-diaminopimelate." [] xref: EC:5.1.1.7 xref: GO:0008837 "molecular_function:diaminopimelate epimerase activity" relationship: has_input_compound UPa:UPC00666 {cardinality="1", is_alternate="False", is_primary="True"} ! LL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: part_of UPa:ULS00009 {cardinality="1", order="1"} ! DL-2,6-diaminopimelate from LL-2,6-diaminopimelate [Term] id: UPa:UER00026 name: DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1 namespace: enzymatic_reaction def: "1 (S)-tetrahydrodipicolinate + 1 H(+) + 1 H(2)O + 1 NADPH + 1 NH(3) => 1 DL-2,6-diaminopimelate + 1 NADP(+)." [] xref: EC:1.4.1.16 xref: GO:0047850 "molecular_function:diaminopimelate dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC03972 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-tetrahydrodipicolinate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: part_of UPa:ULS00010 {cardinality="1", order="1"} ! DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate [Term] id: UPa:UER00027 name: L-lysine from DL-2,6-diaminopimelate: step 1/1 namespace: enzymatic_reaction def: "1 DL-2,6-diaminopimelate => 1 CO(2) + 1 L-lysine." [] xref: EC:4.1.1.20 xref: GO:0008836 "molecular_function:diaminopimelate decarboxylase activity" relationship: has_input_compound UPa:UPC00680 {cardinality="1", is_alternate="False", is_primary="True"} ! DL-2,6-diaminopimelate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: part_of UPa:ULS00011 {cardinality="1", order="1"} ! L-lysine from DL-2,6-diaminopimelate [Term] id: UPa:UER00028 name: L-alpha-aminoadipate from 2-oxoglutarate: step 1/5 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 H(2)O + 1 acetyl-CoA => 1 (R)-homocitrate + 1 CoA." [] xref: EC:2.3.3.14 xref: GO:0004410 "molecular_function:homocitrate synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01251 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-homocitrate relationship: part_of UPa:ULS00012 {cardinality="1", order="1"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00029 name: L-alpha-aminoadipate from 2-oxoglutarate: step 2/5 namespace: enzymatic_reaction def: "1 (R)-homocitrate => 1 H(2)O + 1 homo-cis-aconitate." [] xref: EC:4.2.1 xref: GO:0008659 "molecular_function:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" xref: GO:0016836 "molecular_function:hydro-lyase activity" xref: GO:0018807 "molecular_function:6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018808 "molecular_function:trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity" xref: GO:0018809 "molecular_function:E-phenylitaconyl-CoA hydratase activity" xref: GO:0018810 "molecular_function:trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity" xref: GO:0018811 "molecular_function:cyclohex-1-ene-1-carboxyl-CoA hydratase activity" xref: GO:0018812 "molecular_function:3-hydroxyacyl-CoA dehydratase activity" xref: GO:0018813 "molecular_function:trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity" xref: GO:0018815 "molecular_function:3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity" xref: GO:0018816 "molecular_function:2-hydroxyisobutyrate dehydratase activity" xref: GO:0018817 "molecular_function:2-oxo-hept-3-ene-1,7-dioate hydratase activity" xref: GO:0034561 "molecular_function:1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity" xref: GO:0034578 "molecular_function:limonene 8-hydratase activity" xref: GO:0034581 "molecular_function:4-methyloct-2-enoyl-CoA hydratase activity" xref: GO:0034829 "molecular_function:2-hydroxydec-2,4-diene-1,10-dioate hydratase activity" xref: GO:0034839 "molecular_function:menth-2-enone hydratase activity" xref: GO:0034846 "molecular_function:naphthyl-2-methylene-succinyl-CoA lyase activity" xref: GO:0034856 "molecular_function:2-hydroxyhexa-2,4-dienoate hydratase activity" xref: GO:0034867 "molecular_function:2,4,4-trimethylpent-2-enoyl-CoA hydratase activity" xref: GO:0034890 "molecular_function:endosulfan diol hydrolyase (cyclizing) activity" xref: GO:0034904 "molecular_function:5-chloro-2-oxopent-4-enoate hydratase activity" xref: GO:0034917 "molecular_function:2-methylhex-2-enoyl-CoA hydratase activity" xref: GO:0034953 "molecular_function:perillyl-CoA hydratase activity" xref: GO:0043724 "molecular_function:2-keto-3-deoxygalactonate aldolase activity" xref: GO:0043725 "molecular_function:2-keto-3-deoxygluconate aldolase activity" xref: GO:0043956 "molecular_function:3-hydroxypropionyl-CoA dehydratase activity" xref: GO:0043960 "molecular_function:L-erythro-3-methylmalyl-CoA dehydratase activity" xref: GO:0046565 "molecular_function:3-dehydroshikimate dehydratase activity" xref: GO:0051909 "molecular_function:acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate" xref: GO:0052684 "molecular_function:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity" xref: GO:0052855 "molecular_function:ADP-dependent NAD(P)H-hydrate dehydratase activity" xref: GO:0070497 "molecular_function:6-carboxy-5,6,7,8-tetrahydropterin synthase activity" relationship: has_input_compound UPa:UPC01251 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-homocitrate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC04002 {cardinality="1", is_alternate="False", is_primary="True"} ! homo-cis-aconitate relationship: part_of UPa:ULS00012 {cardinality="1", order="2"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00030 name: L-alpha-aminoadipate from 2-oxoglutarate: step 4/5 namespace: enzymatic_reaction def: "1 NAD(+) + 1 homoisocitrate => 1 2-oxoadipate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.87 xref: GO:0047046 "molecular_function:homoisocitrate dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC05662 {cardinality="1", is_alternate="False", is_primary="True"} ! homoisocitrate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: part_of UPa:ULS00012 {cardinality="1", order="4"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00031 name: L-alpha-aminoadipate from 2-oxoglutarate: step 5/5 namespace: enzymatic_reaction def: "1 2-oxoadipate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-alpha-aminoadipate." [] xref: EC:2.6.1.39 xref: GO:0047536 "molecular_function:2-aminoadipate transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00322 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxoadipate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: part_of UPa:ULS00012 {cardinality="1", order="5"} ! L-alpha-aminoadipate from 2-oxoglutarate [Term] id: UPa:UER00032 name: L-lysine from L-alpha-aminoadipate (fungal route): step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH => 1 AMP + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) + 1 diphosphate + 1 holo-Lys2." [] xref: EC:1.2.1.31 xref: GO:0004043 "molecular_function:L-aminoadipate-semialdehyde dehydrogenase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC11482 {cardinality="1", is_alternate="False", is_primary="False"} ! holo-Lys2 relationship: part_of UPa:ULS00013 {cardinality="1", order="1"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00033 name: L-lysine from L-alpha-aminoadipate (fungal route): step 2/3 namespace: enzymatic_reaction def: "1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine." [] xref: EC:1.5.1.10 xref: GO:0004755 "molecular_function:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04076 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2-aminoadipate 6-semialdahyde relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: part_of UPa:ULS00013 {cardinality="1", order="2"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00034 name: L-lysine from L-alpha-aminoadipate (fungal route): step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADH." [] xref: EC:1.5.1.7 xref: GO:0004754 "molecular_function:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00449 {cardinality="1", is_alternate="False", is_primary="True"} ! saccharopine relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00013 {cardinality="1", order="3"} ! L-lysine from L-alpha-aminoadipate (fungal route) [Term] id: UPa:UER00035 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5 namespace: enzymatic_reaction def: "1 ATP + 1 L-alpha-aminoadipate + 1 [LysW] => 1 ADP + 1 [LysW]-L-2-aminoadipate + 1 phosphate." [] relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_input_compound UPa:UPC19885 {cardinality="1", is_alternate="False", is_primary="False"} ! [LysW] relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC19886 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate relationship: part_of UPa:ULS00014 {cardinality="1", order="1"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00036 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5 namespace: enzymatic_reaction def: "1 ATP + 1 [LysW]-L-2-aminoadipate => 1 ADP + 1 [LysW]-L-2-aminoadipyl 6-phosphate." [] xref: EC:2.7.2 xref: GO:0016774 "molecular_function:phosphotransferase activity, carboxyl group as acceptor" xref: GO:0036357 "molecular_function:2-phosphoglycerate kinase activity" xref: GO:0043744 "molecular_function:N2-acetyl-L-aminoadipate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC19886 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC19887 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: part_of UPa:ULS00014 {cardinality="1", order="2"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00037 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 [LysW]-L-2-aminoadipyl 6-phosphate => 1 NADP(+) + 1 [LysW]-L-2-aminoadipate 6-semialdehyde + 1 phosphate." [] xref: EC:1.2.1 xref: GO:0004028 "molecular_function:3-chloroallyl aldehyde dehydrogenase activity" xref: GO:0016620 "molecular_function:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" xref: GO:0018472 "molecular_function:1-hydroxy-2-naphthaldehyde dehydrogenase activity" xref: GO:0018473 "molecular_function:cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0018474 "molecular_function:2-carboxybenzaldehyde dehydrogenase activity" xref: GO:0018475 "molecular_function:trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity" xref: GO:0019115 "molecular_function:benzaldehyde dehydrogenase activity" xref: GO:0034520 "molecular_function:2-naphthaldehyde dehydrogenase activity" xref: GO:0034525 "molecular_function:1-naphthaldehyde dehydrogenase activity" xref: GO:0034530 "molecular_function:4-hydroxymethylsalicyaldehyde dehydrogenase activity" xref: GO:0034538 "molecular_function:3-methylsalicylaldehyde dehydrogenase activity" xref: GO:0034601 "molecular_function:oxoglutarate dehydrogenase [NAD(P)+] activity" xref: GO:0034602 "molecular_function:oxoglutarate dehydrogenase (NAD+) activity" xref: GO:0034603 "molecular_function:pyruvate dehydrogenase [NAD(P)+] activity" xref: GO:0034604 "molecular_function:pyruvate dehydrogenase (NAD+) activity" xref: GO:0034822 "molecular_function:citronellal dehydrogenase activity" xref: GO:0034832 "molecular_function:geranial dehydrogenase activity" xref: GO:0043745 "molecular_function:N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity" xref: GO:0043796 "molecular_function:glyceraldehyde dehydrogenase (NADP) activity" xref: GO:0043870 "molecular_function:N-acetyl-gamma-aminoadipyl-phosphate reductase activity" xref: GO:0043878 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity" xref: GO:0044104 "molecular_function:2,5-dioxovalerate dehydrogenase (NAD+) activity" xref: GO:0052814 "molecular_function:medium-chain-aldehyde dehydrogenase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC19887 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipyl 6-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC19888 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: part_of UPa:ULS00014 {cardinality="1", order="3"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00038 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5 namespace: enzymatic_reaction def: "1 L-glutamate + 1 [LysW]-L-2-aminoadipate 6-semialdehyde => 1 2-oxoglutarate + 1 [LysW]-L-lysine." [] xref: EC:2.6.1 xref: GO:0008483 "molecular_function:transaminase activity" xref: GO:0010326 "molecular_function:methionine-oxo-acid transaminase activity" xref: GO:0018719 "molecular_function:6-aminohexanoate transaminase activity" xref: GO:0043746 "molecular_function:N2-acetyl-L-lysine aminotransferase activity" xref: GO:0043760 "molecular_function:acetyldiaminopimelate aminotransferase activity" xref: GO:0043840 "molecular_function:branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" xref: GO:0043911 "molecular_function:D-lysine transaminase activity" xref: GO:0046571 "molecular_function:aspartate-2-keto-4-methylthiobutyrate transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC19888 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-2-aminoadipate 6-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC19889 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-lysine relationship: part_of UPa:ULS00014 {cardinality="1", order="4"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00039 name: L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 [LysW]-L-lysine => 1 L-lysine + 1 [LysW]." [] xref: EC:3.5.1 xref: GO:0008418 "molecular_function:protein-N-terminal asparagine amidohydrolase activity" xref: GO:0008759 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity" xref: GO:0016811 "molecular_function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" xref: GO:0018748 "molecular_function:iprodione amidohydrolase activity" xref: GO:0018749 "molecular_function:(3,5-dichlorophenylurea)acetate amidohydrolase activity" xref: GO:0034571 "molecular_function:4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity" xref: GO:0034573 "molecular_function:didemethylisoproturon amidohydrolase activity" xref: GO:0034576 "molecular_function:N-isopropylacetanilide amidohydrolase activity" xref: GO:0034781 "molecular_function:N-cyclohexylformamide amidohydrolase activity" xref: GO:0034876 "molecular_function:isonicotinic acid hydrazide hydrolase activity" xref: GO:0034882 "molecular_function:cis-aconitamide amidase activity" xref: GO:0034885 "molecular_function:gamma-N-formylaminovinylacetate hydrolase activity" xref: GO:0043747 "molecular_function:N2-acetyl-L-lysine deacetylase activity" xref: GO:0043748 "molecular_function:O-succinylbenzoate synthase activity" xref: GO:0043864 "molecular_function:indoleacetamide hydrolase activity" xref: GO:0043909 "molecular_function:N-acetylcitrulline deacetylase activity" xref: GO:0047419 "molecular_function:N-acetylgalactosamine-6-phosphate deacetylase activity" xref: GO:0052773 "molecular_function:diacetylchitobiose deacetylase activity" xref: GO:0052790 "molecular_function:chitooligosaccharide deacetylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC19889 {cardinality="1", is_alternate="False", is_primary="True"} ! [LysW]-L-lysine relationship: has_output_compound UPa:UPC00047 {cardinality="1", is_alternate="False", is_primary="True"} ! L-lysine relationship: has_output_compound UPa:UPC19885 {cardinality="1", is_alternate="False", is_primary="False"} ! [LysW] relationship: part_of UPa:ULS00014 {cardinality="1", order="5"} ! L-lysine from L-alpha-aminoadipate (Thermus route) [Term] id: UPa:UER00040 name: L-tryptophan from chorismate: step 1/5 namespace: enzymatic_reaction def: "1 L-glutamine + 1 NH(3) + 1 chorismate => 1 L-glutamate + 1 anthranilate + 1 pyruvate." [] xref: EC:4.1.3.27 xref: GO:0004049 "molecular_function:anthranilate synthase activity" relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: part_of UPa:ULS00016 {cardinality="1", order="1"} ! L-tryptophan from chorismate [Term] id: UPa:UER00041 name: L-tryptophan from chorismate: step 2/5 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 anthranilate => 1 N-(5-phospho-beta-D-ribosyl)anthranilic acid + 1 diphosphate." [] xref: EC:2.4.2.18 xref: GO:0004048 "molecular_function:anthranilate phosphoribosyltransferase activity" relationship: has_input_compound UPa:UPC00108 {cardinality="1", is_alternate="False", is_primary="True"} ! anthranilate relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC04302 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: part_of UPa:ULS00016 {cardinality="1", order="2"} ! L-tryptophan from chorismate [Term] id: UPa:UER00042 name: L-tryptophan from chorismate: step 3/5 namespace: enzymatic_reaction def: "1 N-(5-phospho-beta-D-ribosyl)anthranilic acid => 1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [] xref: EC:5.3.1.24 xref: GO:0004640 "molecular_function:phosphoribosylanthranilate isomerase activity" relationship: has_input_compound UPa:UPC04302 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(5-phospho-beta-D-ribosyl)anthranilic acid relationship: has_output_compound UPa:UPC01302 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="3"} ! L-tryptophan from chorismate [Term] id: UPa:UER00043 name: L-tryptophan from chorismate: step 4/5 namespace: enzymatic_reaction def: "1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => 1 CO(2) + 1 H(2)O + 1 indoleglycerol phosphate." [] xref: EC:4.1.1.48 xref: GO:0004425 "molecular_function:indole-3-glycerol-phosphate synthase activity" relationship: has_input_compound UPa:UPC01302 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC03506 {cardinality="1", is_alternate="False", is_primary="True"} ! indoleglycerol phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="4"} ! L-tryptophan from chorismate [Term] id: UPa:UER00044 name: L-tryptophan from chorismate: step 5/5 namespace: enzymatic_reaction def: "1 L-serine + 1 indoleglycerol phosphate => 1 D-glyceraldehyde 3-phosphate + 1 H(2)O + 1 L-tryptophan." [] xref: EC:4.2.1.20 xref: GO:0004834 "molecular_function:tryptophan synthase activity" relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="False"} ! L-serine relationship: has_input_compound UPa:UPC03506 {cardinality="1", is_alternate="False", is_primary="True"} ! indoleglycerol phosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00078 {cardinality="1", is_alternate="False", is_primary="True"} ! L-tryptophan relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="False"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00016 {cardinality="1", order="5"} ! L-tryptophan from chorismate [Term] id: UPa:UER00053 name: taxol from baccatin III: step 3/3 namespace: enzymatic_reaction def: "1 N-(3'R)-debenzoyltaxol + 1 benzoyl-CoA => 1 CoA + 1 taxol." [] xref: EC:2.3.1 xref: GO:0004147 "molecular_function:dihydrolipoamide branched chain acyltransferase activity" xref: GO:0004772 "molecular_function:sterol O-acyltransferase activity" xref: GO:0008080 "molecular_function:N-acetyltransferase activity" xref: GO:0008374 "molecular_function:O-acyltransferase activity" xref: GO:0008951 "molecular_function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity" xref: GO:0016406 "molecular_function:carnitine O-acyltransferase activity" xref: GO:0016407 "molecular_function:acetyltransferase activity" xref: GO:0016408 "molecular_function:C-acyltransferase activity" xref: GO:0016409 "molecular_function:palmitoyltransferase activity" xref: GO:0016410 "molecular_function:N-acyltransferase activity" xref: GO:0016411 "molecular_function:acylglycerol O-acyltransferase activity" xref: GO:0016412 "molecular_function:serine O-acyltransferase activity" xref: GO:0016413 "molecular_function:O-acetyltransferase activity" xref: GO:0016414 "molecular_function:O-octanoyltransferase activity" xref: GO:0016415 "molecular_function:octanoyltransferase activity" xref: GO:0016416 "molecular_function:O-palmitoyltransferase activity" xref: GO:0016417 "molecular_function:S-acyltransferase activity" xref: GO:0016418 "molecular_function:S-acetyltransferase activity" xref: GO:0016419 "molecular_function:S-malonyltransferase activity" xref: GO:0016420 "molecular_function:malonyltransferase activity" xref: GO:0016454 "molecular_function:C-palmitoyltransferase activity" xref: GO:0016747 "molecular_function:transferase activity, transferring acyl groups other than amino-acyl groups" xref: GO:0016748 "molecular_function:succinyltransferase activity" xref: GO:0016749 "molecular_function:N-succinyltransferase activity" xref: GO:0016750 "molecular_function:O-succinyltransferase activity" xref: GO:0016751 "molecular_function:S-succinyltransferase activity" xref: GO:0016752 "molecular_function:sinapoyltransferase activity" xref: GO:0016753 "molecular_function:O-sinapoyltransferase activity" xref: GO:0018030 "molecular_function:peptidyl-lysine N6-myristoyltransferase activity" xref: GO:0018031 "molecular_function:peptidyl-lysine N6-palmitoyltransferase activity" xref: GO:0018711 "molecular_function:benzoyl acetate-CoA thiolase activity" xref: GO:0018712 "molecular_function:3-hydroxybutyryl-CoA thiolase activity" xref: GO:0018713 "molecular_function:3-ketopimelyl-CoA thiolase activity" xref: GO:0019105 "molecular_function:N-palmitoyltransferase activity" xref: GO:0019107 "molecular_function:myristoyltransferase activity" xref: GO:0019186 "molecular_function:acyl-CoA N-acyltransferase activity" xref: GO:0019705 "molecular_function:protein-cysteine S-myristoyltransferase activity" xref: GO:0019707 "molecular_function:protein-cysteine S-acyltransferase activity" xref: GO:0030523 "molecular_function:dihydrolipoamide S-acyltransferase activity" xref: GO:0032216 "molecular_function:glucosaminyl-phosphotidylinositol O-acyltransferase activity" xref: GO:0034737 "molecular_function:ergosterol O-acyltransferase activity" xref: GO:0034738 "molecular_function:lanosterol O-acyltransferase activity" xref: GO:0034848 "molecular_function:naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity" xref: GO:0034851 "molecular_function:2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity" xref: GO:0034915 "molecular_function:2-methylhexanoyl-CoA C-acetyltransferase activity" xref: GO:0034919 "molecular_function:butyryl-CoA 2-C-propionyltransferase activity" xref: GO:0034945 "molecular_function:2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity" xref: GO:0043741 "molecular_function:L-2-aminoadipate N-acetyltransferase activity" xref: GO:0043764 "molecular_function:UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" xref: GO:0043806 "molecular_function:keto acid formate lyase activity" xref: GO:0043849 "molecular_function:Ras palmitoyltransferase activity" xref: GO:0043875 "molecular_function:2-ketobutyrate formate-lyase activity" xref: GO:0046941 "molecular_function:azetidine-2-carboxylic acid acetyltransferase activity" xref: GO:0052858 "molecular_function:peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" xref: GO:0090595 "molecular_function:acetyl-CoA:L-lysine N6-acetyltransferase" relationship: has_input_compound UPa:UPC00512 {cardinality="1", is_alternate="False", is_primary="False"} ! benzoyl-CoA relationship: has_input_compound UPa:UPC16524 {cardinality="1", is_alternate="False", is_primary="True"} ! N-(3'R)-debenzoyltaxol relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC07394 {cardinality="1", is_alternate="False", is_primary="True"} ! taxol relationship: part_of UPa:ULS00408 {cardinality="1", order="3"} ! taxol from baccatin III [Term] id: UPa:UER00054 name: 2-oxobutanoate from L-threonine: step 1/1 namespace: enzymatic_reaction def: "1 L-threonine => 1 2-oxobutanoate + 1 NH(3)." [] xref: EC:4.3.1.19 xref: GO:0004794 "molecular_function:L-threonine ammonia-lyase activity" relationship: has_input_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: part_of UPa:ULS00018 {cardinality="1", order="1"} ! 2-oxobutanoate from L-threonine [Term] id: UPa:UER00055 name: L-isoleucine from 2-oxobutanoate: step 1/4 namespace: enzymatic_reaction def: "1 2-hydroxyethyl-ThPP + 1 2-oxobutanoate => 1 (S)-2-acetyl-2-hydroxybutanoic acid + 1 thiamine diphosphate." [] xref: EC:2.2.1.6 xref: GO:0003984 "molecular_function:acetolactate synthase activity" relationship: has_input_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: has_input_compound UPa:UPC05125 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-hydroxyethyl-ThPP relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="False"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06006 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: part_of UPa:ULS00020 {cardinality="1", order="1"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00056 name: L-isoleucine from 2-oxobutanoate: step 2/4 namespace: enzymatic_reaction def: "1 (S)-2-acetyl-2-hydroxybutanoic acid + 1 H(+) + 1 NADPH => 1 (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid + 1 NADP(+)." [] xref: EC:1.1.1.86 xref: GO:0004455 "molecular_function:ketol-acid reductoisomerase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06006 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetyl-2-hydroxybutanoic acid relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC06007 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: part_of UPa:ULS00020 {cardinality="1", order="2"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00057 name: L-isoleucine from 2-oxobutanoate: step 3/4 namespace: enzymatic_reaction def: "1 (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid => 1 (S)-3-methyl-2-oxopentanoate + 1 H(2)O." [] xref: EC:4.2.1.9 xref: GO:0004160 "molecular_function:dihydroxy-acid dehydratase activity" relationship: has_input_compound UPa:UPC06007 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00671 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-methyl-2-oxopentanoate relationship: part_of UPa:ULS00020 {cardinality="1", order="3"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00058 name: L-isoleucine from 2-oxobutanoate: step 4/4 namespace: enzymatic_reaction def: "1 (S)-3-methyl-2-oxopentanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-isoleucine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00671 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00407 {cardinality="1", is_alternate="False", is_primary="True"} ! L-isoleucine relationship: part_of UPa:ULS00020 {cardinality="1", order="4"} ! L-isoleucine from 2-oxobutanoate [Term] id: UPa:UER00059 name: L-valine from pyruvate: step 1/4 namespace: enzymatic_reaction def: "1 pyruvate => 1 (S)-2-acetolactate + 1 CO(2) + 1 thiamine diphosphate." [] xref: EC:2.2.1.6 xref: GO:0003984 "molecular_function:acetolactate synthase activity" relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="False"} ! thiamine diphosphate relationship: has_output_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: part_of UPa:ULS00021 {cardinality="1", order="1"} ! L-valine from pyruvate [Term] id: UPa:UER00060 name: L-valine from pyruvate: step 2/4 namespace: enzymatic_reaction def: "1 (S)-2-acetolactate + 1 H(+) + 1 NADPH => 1 (R)-2,3-dihydroxy-3-methylbutanoate + 1 NADP(+)." [] xref: EC:1.1.1.86 xref: GO:0004455 "molecular_function:ketol-acid reductoisomerase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06010 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-2-acetolactate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC04272 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: part_of UPa:ULS00021 {cardinality="1", order="2"} ! L-valine from pyruvate [Term] id: UPa:UER00061 name: L-valine from pyruvate: step 3/4 namespace: enzymatic_reaction def: "1 (R)-2,3-dihydroxy-3-methylbutanoate => 1 3-methyl-2-oxobutanoate + 1 H(2)O." [] xref: EC:4.2.1.9 xref: GO:0004160 "molecular_function:dihydroxy-acid dehydratase activity" relationship: has_input_compound UPa:UPC04272 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-2,3-dihydroxy-3-methylbutanoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: part_of UPa:ULS00021 {cardinality="1", order="3"} ! L-valine from pyruvate [Term] id: UPa:UER00062 name: L-valine from pyruvate: step 4/4 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-valine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00183 {cardinality="1", is_alternate="False", is_primary="True"} ! L-valine relationship: part_of UPa:ULS00021 {cardinality="1", order="4"} ! L-valine from pyruvate [Term] id: UPa:UER00063 name: L-threonine from L-aspartate: step 3/5 namespace: enzymatic_reaction def: "H(+) + L-aspartate 4-semialdehyde + [NADH or NADPH] => L-homoserine + [NAD(+) or NADP(+)]." [] xref: EC:1.1.1.3 xref: GO:0004412 "molecular_function:homoserine dehydrogenase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: part_of UPa:ULS00022 {cardinality="1", order="3"} ! L-threonine from L-aspartate [Term] id: UPa:UER00064 name: L-threonine from L-aspartate: step 4/5 namespace: enzymatic_reaction def: "1 ATP + 1 L-homoserine => 1 ADP + 1 O-phospho-L-homoserine." [] xref: EC:2.7.1.39 xref: GO:0004413 "molecular_function:homoserine kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01102 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-homoserine relationship: part_of UPa:ULS00022 {cardinality="1", order="4"} ! L-threonine from L-aspartate [Term] id: UPa:UER00065 name: L-threonine from L-aspartate: step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 O-phospho-L-homoserine => 1 L-threonine + 1 phosphate." [] xref: EC:4.2.3.1 xref: GO:0004795 "molecular_function:threonine synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01102 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-homoserine relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00188 {cardinality="1", is_alternate="False", is_primary="True"} ! L-threonine relationship: part_of UPa:ULS00022 {cardinality="1", order="5"} ! L-threonine from L-aspartate [Term] id: UPa:UER00066 name: 2-oxobutanoate from pyruvate: step 1/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetyl-CoA + 1 pyruvate => 1 (R)-citramalate + 1 CoA." [] xref: EC:2.3.1.182 relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC02612 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-citramalate relationship: part_of UPa:ULS00019 {cardinality="1", order="1"} ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00067 name: 2-oxobutanoate from pyruvate: step 2/3 namespace: enzymatic_reaction def: "1 (R)-citramalate => 1 D-erythro-3-methylmalic acid." [] xref: EC:4.2.1.35 xref: GO:0047508 "molecular_function:(R)-2-methylmalate dehydratase activity" relationship: has_input_compound UPa:UPC02612 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-citramalate relationship: has_output_compound UPa:UPC06032 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-3-methylmalic acid relationship: part_of UPa:ULS00019 {cardinality="1", order="2"} ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00069 name: 2-oxobutanoate from pyruvate: step 3/3 namespace: enzymatic_reaction def: "1 D-erythro-3-methylmalic acid + 1 NAD(+) => 1 2-oxobutanoate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.n5 relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06032 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythro-3-methylmalic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-oxobutanoate relationship: part_of UPa:ULS00019 {cardinality="1", order="3"} ! 2-oxobutanoate from pyruvate [Term] id: UPa:UER00070 name: L-leucine from 3-methyl-2-oxobutanoate: step 1/4 namespace: enzymatic_reaction def: "1 3-methyl-2-oxobutanoate + 1 H(2)O + 1 acetyl-CoA => 1 (2S)-2-isopropylmalate + 1 CoA." [] xref: EC:2.3.3.13 xref: GO:0003852 "molecular_function:2-isopropylmalate synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00141 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-methyl-2-oxobutanoate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC02504 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-isopropylmalate relationship: part_of UPa:ULS00023 {cardinality="1", order="1"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00071 name: L-leucine from 3-methyl-2-oxobutanoate: step 2/4 namespace: enzymatic_reaction def: "1 (2S)-2-isopropylmalate => 1 (2R,3S)-3-isopropylmalate." [] xref: EC:4.2.1.33 xref: GO:0003861 "molecular_function:3-isopropylmalate dehydratase activity" relationship: has_input_compound UPa:UPC02504 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-isopropylmalate relationship: has_output_compound UPa:UPC04411 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-3-isopropylmalate relationship: part_of UPa:ULS00023 {cardinality="1", order="2"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00072 name: L-leucine from 3-methyl-2-oxobutanoate: step 3/4 namespace: enzymatic_reaction def: "1 (2R,3S)-3-isopropylmalate + 1 NAD(+) => 1 4-methyl-2-oxopentanoate + 1 CO(2) + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.85 xref: GO:0003862 "molecular_function:3-isopropylmalate dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC04411 {cardinality="1", is_alternate="False", is_primary="True"} ! (2R,3S)-3-isopropylmalate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: part_of UPa:ULS00023 {cardinality="1", order="3"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00073 name: L-leucine from 3-methyl-2-oxobutanoate: step 4/4 namespace: enzymatic_reaction def: "1 4-methyl-2-oxopentanoate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-leucine." [] xref: EC:2.6.1.42 xref: GO:0004084 "molecular_function:branched-chain-amino-acid transaminase activity" xref: GO:0052654 "molecular_function:L-leucine transaminase activity" xref: GO:0052655 "molecular_function:L-valine transaminase activity" xref: GO:0052656 "molecular_function:L-isoleucine transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00233 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-2-oxopentanoate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00123 {cardinality="1", is_alternate="False", is_primary="True"} ! L-leucine relationship: part_of UPa:ULS00023 {cardinality="1", order="4"} ! L-leucine from 3-methyl-2-oxobutanoate [Term] id: UPa:UER00074 name: O-acetyl-L-homoserine from L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-homoserine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-homoserine." [] xref: EC:2.3.1.31 xref: GO:0004414 "molecular_function:homoserine O-acetyltransferase activity" relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01077 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-homoserine relationship: part_of UPa:ULS00026 {cardinality="1", order="1"} ! O-acetyl-L-homoserine from L-homoserine [Term] id: UPa:UER00075 name: O-succinyl-L-homoserine from L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-homoserine + 1 succinyl-CoA => 1 CoA + 1 O-succinyl-L-homoserine." [] xref: EC:2.3.1.46 xref: GO:0008899 "molecular_function:homoserine O-succinyltransferase activity" relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00263 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homoserine relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC01118 {cardinality="1", is_alternate="False", is_primary="True"} ! O-succinyl-L-homoserine relationship: part_of UPa:ULS00027 {cardinality="1", order="1"} ! O-succinyl-L-homoserine from L-homoserine [Term] id: UPa:UER00076 name: L-homocysteine from S-adenosyl-L-homocysteine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-adenosyl-L-homocysteine => 1 L-homocysteine + 1 adenosine." [] xref: EC:3.3.1.1 xref: GO:0004013 "molecular_function:adenosylhomocysteinase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00212 {cardinality="1", is_alternate="False", is_primary="False"} ! adenosine relationship: part_of UPa:ULS00028 {cardinality="1", order="1"} ! L-homocysteine from S-adenosyl-L-homocysteine [Term] id: UPa:UER00077 name: L-cystathionine from O-succinyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 L-cysteine + 1 O-succinyl-L-homoserine => 1 L-cystathionine + 1 succinate." [] xref: EC:2.5.1.48 xref: GO:0003962 "molecular_function:cystathionine gamma-synthase activity" relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="False"} ! L-cysteine relationship: has_input_compound UPa:UPC01118 {cardinality="1", is_alternate="False", is_primary="True"} ! O-succinyl-L-homoserine relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: part_of UPa:ULS00029 {cardinality="1", order="1"} ! L-cystathionine from O-succinyl-L-homoserine [Term] id: UPa:UER00078 name: L-homocysteine from L-cystathionine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-cystathionine => 1 L-homocysteine + 1 NH(3) + 1 pyruvate." [] xref: EC:4.4.1.8 xref: GO:0004121 "molecular_function:cystathionine beta-lyase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: part_of UPa:ULS00030 {cardinality="1", order="1"} ! L-homocysteine from L-cystathionine [Term] id: UPa:UER00079 name: L-homocysteine from O-acetyl-L-homoserine: step 1/1 namespace: enzymatic_reaction def: "1 O-acetyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 acetate." [] xref: EC:2.5.1.49 xref: GO:0003961 "molecular_function:O-acetylhomoserine aminocarboxypropyltransferase activity" relationship: has_input_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC01077 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-homoserine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: part_of UPa:ULS00031 {cardinality="1", order="1"} ! L-homocysteine from O-acetyl-L-homoserine [Term] id: UPa:UER00080 name: S-adenosyl-L-methionine from L-methionine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-methionine => 1 S-adenosyl-L-methionine + 1 diphosphate + 1 phosphate." [] xref: EC:2.5.1.6 xref: GO:0004478 "molecular_function:methionine adenosyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="True"} ! S-adenosyl-L-methionine relationship: part_of UPa:ULS00032 {cardinality="1", order="1"} ! S-adenosyl-L-methionine from L-methionine [Term] id: UPa:UER00081 name: L-methionine from L-homocysteine (MetH route): step 1/1 namespace: enzymatic_reaction def: "1 5-methyl-THF + 1 L-homocysteine => 1 5,6,7,8-tetrahydrofolate + 1 L-methionine." [] xref: EC:2.1.1.13 xref: GO:0008705 "molecular_function:methionine synthase activity" relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC00440 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-methyl-THF relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00033 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (MetH route) [Term] id: UPa:UER00082 name: L-methionine from L-homocysteine (MetE route): step 1/1 namespace: enzymatic_reaction def: "1 5-methyltetrahydropteroyltri-L-glutamate + 1 L-homocysteine => 1 L-methionine + 1 tetrahydropteroyltri-L-glutamate." [] xref: EC:2.1.1.14 xref: GO:0003871 "molecular_function:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity" relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC04489 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-methyltetrahydropteroyltri-L-glutamate relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC04144 {cardinality="1", is_alternate="False", is_primary="False"} ! tetrahydropteroyltri-L-glutamate relationship: part_of UPa:ULS00034 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (MetE route) [Term] id: UPa:UER00083 name: L-methionine from L-homocysteine (BhmT route): step 1/1 namespace: enzymatic_reaction def: "1 L-homocysteine + 1 betaine => 1 L-methionine + 1 N,N-dimethylglycine." [] xref: EC:2.1.1.5 xref: GO:0047150 "molecular_function:betaine-homocysteine S-methyltransferase activity" relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_input_compound UPa:UPC00719 {cardinality="1", is_alternate="False", is_primary="False"} ! betaine relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="True"} ! L-methionine relationship: has_output_compound UPa:UPC01026 {cardinality="1", is_alternate="False", is_primary="False"} ! N,N-dimethylglycine relationship: part_of UPa:ULS00035 {cardinality="1", order="1"} ! L-methionine from L-homocysteine (BhmT route) [Term] id: UPa:UER00084 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7 namespace: enzymatic_reaction def: "1 D-erythrose 4-phosphate + 1 H(2)O + 1 phosphoenolpyruvate => 1 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + 1 phosphate." [] xref: EC:2.5.1.54 xref: GO:0003849 "molecular_function:3-deoxy-7-phosphoheptulonate synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC00279 {cardinality="1", is_alternate="False", is_primary="True"} ! D-erythrose 4-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04691 {cardinality="1", is_alternate="False", is_primary="True"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: part_of UPa:ULS00036 {cardinality="1", order="1"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00085 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7 namespace: enzymatic_reaction def: "1 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 1 3-dehydroquinate + 1 phosphate." [] xref: EC:4.2.3.4 xref: GO:0003856 "molecular_function:3-dehydroquinate synthase activity" relationship: has_input_compound UPa:UPC04691 {cardinality="1", is_alternate="False", is_primary="True"} ! 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: part_of UPa:ULS00036 {cardinality="1", order="2"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00086 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7 namespace: enzymatic_reaction def: "1 3-dehydroquinate => 1 3-dehydroshikimate + 1 H(2)O." [] xref: EC:4.2.1.10 xref: GO:0003855 "molecular_function:3-dehydroquinate dehydratase activity" relationship: has_input_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="3"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00087 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7 namespace: enzymatic_reaction def: "1 3-dehydroshikimate + 1 H(+) + 1 NADPH => 1 NADP(+) + 1 shikimate." [] xref: EC:1.1.1.25 xref: EC:1.1.1.282 xref: GO:0004764 "molecular_function:shikimate 3-dehydrogenase (NADP+) activity" xref: GO:0030266 "molecular_function:quinate 3-dehydrogenase (NAD+) activity" xref: GO:0052733 "molecular_function:quinate 3-dehydrogenase (NADP+) activity" xref: GO:0052734 "molecular_function:shikimate 3-dehydrogenase (NAD+) activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00493 {cardinality="1", is_alternate="False", is_primary="True"} ! shikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="4"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00088 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7 namespace: enzymatic_reaction def: "1 ATP + 1 shikimate => 1 3-phosphoshikimate + 1 ADP." [] xref: EC:2.7.1.71 xref: GO:0004765 "molecular_function:shikimate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00493 {cardinality="1", is_alternate="False", is_primary="True"} ! shikimate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC03175 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphoshikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="5"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00089 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7 namespace: enzymatic_reaction def: "1 3-phosphoshikimate + 1 phosphoenolpyruvate => 1 5-O-(1-carboxyvinyl)-3-phosphoshikimate + 1 phosphate." [] xref: EC:2.5.1.19 xref: GO:0003866 "molecular_function:3-phosphoshikimate 1-carboxyvinyltransferase activity" relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphoenolpyruvate relationship: has_input_compound UPa:UPC03175 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01269 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: part_of UPa:ULS00036 {cardinality="1", order="6"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00090 name: chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7 namespace: enzymatic_reaction def: "1 5-O-(1-carboxyvinyl)-3-phosphoshikimate => 1 chorismate + 1 phosphate." [] xref: EC:4.2.3.5 xref: GO:0004107 "molecular_function:chorismate synthase activity" relationship: has_input_compound UPa:UPC01269 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-O-(1-carboxyvinyl)-3-phosphoshikimate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: part_of UPa:ULS00036 {cardinality="1", order="7"} ! chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate [Term] id: UPa:UER00091 name: 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 pyruvate => 1 1-deoxy-D-xylulose 5-phosphate + 1 CO(2)." [] xref: EC:2.2.1.7 xref: GO:0008661 "molecular_function:1-deoxy-D-xylulose-5-phosphate synthase activity" relationship: has_input_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: part_of UPa:ULS00040 {cardinality="1", order="1"} ! 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate [Term] id: UPa:UER00092 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6 namespace: enzymatic_reaction def: "1 1-deoxy-D-xylulose 5-phosphate + 1 H(+) + 1 NADPH => 1 2-C-methyl-D-erythritol 4-phosphate + 1 NADP(+)." [] xref: EC:1.1.1.267 xref: GO:0030604 "molecular_function:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC11434 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="1"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00093 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6 namespace: enzymatic_reaction def: "1 2-C-methyl-D-erythritol 4-phosphate + 1 CTP => 1 4-CDP-2-C-methyl-D-erythritol + 1 diphosphate." [] xref: EC:2.7.7.60 xref: GO:0050518 "molecular_function:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" relationship: has_input_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="False"} ! CTP relationship: has_input_compound UPa:UPC11434 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 4-phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC11435 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol relationship: part_of UPa:ULS00037 {cardinality="1", order="2"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00094 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6 namespace: enzymatic_reaction def: "1 4-CDP-2-C-methyl-D-erythritol + 1 ATP => 1 4-CDP-2-C-methyl-D-erythritol 2-phosphate + 1 ADP." [] xref: EC:2.7.1.148 xref: GO:0050515 "molecular_function:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC11435 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC11436 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="3"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00095 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6 namespace: enzymatic_reaction def: "1 4-CDP-2-C-methyl-D-erythritol 2-phosphate => 1 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 1 CMP." [] xref: EC:4.6.1.12 xref: GO:0008685 "molecular_function:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity" relationship: has_input_compound UPa:UPC11436 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-CDP-2-C-methyl-D-erythritol 2-phosphate relationship: has_output_compound UPa:UPC00055 {cardinality="1", is_alternate="False", is_primary="False"} ! CMP relationship: has_output_compound UPa:UPC11453 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="4"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00096 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6 namespace: enzymatic_reaction def: "1 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced ferredoxin => 1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(2)O + 2 oxidized ferredoxin." [] xref: EC:1.17.7.1 xref: GO:0046429 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity" relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_input_compound UPa:UPC11453 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-C-methyl-D-erythritol 2,4-cyclic diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="5"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00097 name: isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6 namespace: enzymatic_reaction def: "1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(+) + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 isopentenyl diphosphate." [] xref: EC:1.17.1.2 xref: GO:0051745 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: part_of UPa:ULS00037 {cardinality="1", order="6"} ! isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00098 name: isopentenyl diphosphate from (R)-mevalonate: step 1/3 namespace: enzymatic_reaction def: "1 (R)-mevalonate + 1 ATP => 1 (R)-5-phosphomevalonate + 1 ADP." [] xref: EC:2.7.1.36 xref: GO:0004496 "molecular_function:mevalonate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00418 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01107 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-phosphomevalonate relationship: part_of UPa:ULS00038 {cardinality="1", order="1"} ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00099 name: isopentenyl diphosphate from (R)-mevalonate: step 2/3 namespace: enzymatic_reaction def: "1 (R)-5-phosphomevalonate + 1 ATP => 1 (R)-5-diphosphomevalonate + 1 ADP." [] xref: EC:2.7.4.2 xref: GO:0004631 "molecular_function:phosphomevalonate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01107 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-phosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC01143 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-diphosphomevalonate relationship: part_of UPa:ULS00038 {cardinality="1", order="2"} ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00100 name: isopentenyl diphosphate from (R)-mevalonate: step 3/3 namespace: enzymatic_reaction def: "1 (R)-5-diphosphomevalonate + 1 ATP => 1 ADP + 1 CO(2) + 1 isopentenyl diphosphate + 1 phosphate." [] xref: EC:4.1.1.33 xref: GO:0004163 "molecular_function:diphosphomevalonate decarboxylase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01143 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-5-diphosphomevalonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: part_of UPa:ULS00038 {cardinality="1", order="3"} ! isopentenyl diphosphate from (R)-mevalonate [Term] id: UPa:UER00101 name: (R)-mevalonate from acetyl-CoA: step 1/3 namespace: enzymatic_reaction def: "2 acetyl-CoA => 1 CoA + 1 acetoacetyl-CoA." [] xref: EC:2.3.1.9 xref: GO:0003985 "molecular_function:acetyl-CoA C-acetyltransferase activity" relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetyl-CoA relationship: part_of UPa:ULS00039 {cardinality="1", order="1"} ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00102 name: (R)-mevalonate from acetyl-CoA: step 2/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 acetoacetyl-CoA + 1 acetyl-CoA => 1 (S)-3-hydroxy-3-methylglutaryl-CoA + 1 CoA." [] xref: EC:2.3.3.10 xref: GO:0004421 "molecular_function:hydroxymethylglutaryl-CoA synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00332 {cardinality="1", is_alternate="False", is_primary="True"} ! acetoacetyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: part_of UPa:ULS00039 {cardinality="1", order="2"} ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00103 name: (R)-mevalonate from acetyl-CoA: step 3/3 namespace: enzymatic_reaction def: "1 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => 1 (R)-mevalonate + 1 CoA + 2 NADP(+)." [] xref: EC:1.1.1.34 xref: GO:0004420 "molecular_function:hydroxymethylglutaryl-CoA reductase (NADPH) activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00356 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-3-hydroxy-3-methylglutaryl-CoA relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00418 {cardinality="1", is_alternate="False", is_primary="True"} ! (R)-mevalonate relationship: part_of UPa:ULS00039 {cardinality="1", order="3"} ! (R)-mevalonate from acetyl-CoA [Term] id: UPa:UER00104 name: dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 isopentenyl diphosphate => 1 dimethylallyl diphosphate." [] xref: EC:5.3.3.2 xref: GO:0004452 "molecular_function:isopentenyl-diphosphate delta-isomerase activity" relationship: has_input_compound UPa:UPC00129 {cardinality="1", is_alternate="False", is_primary="True"} ! isopentenyl diphosphate relationship: has_output_compound UPa:UPC00235 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylallyl diphosphate relationship: part_of UPa:ULS00041 {cardinality="1", order="1"} ! dimethylallyl diphosphate from isopentenyl diphosphate [Term] id: UPa:UER00105 name: dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1 namespace: enzymatic_reaction def: "1 (2E)-4-hydroxy-3-methylbutenyl diphosphate + 1 H(+) + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 dimethylallyl diphosphate." [] xref: EC:1.17.1.2 xref: GO:0051745 "molecular_function:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11811 {cardinality="1", is_alternate="False", is_primary="True"} ! (2E)-4-hydroxy-3-methylbutenyl diphosphate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00235 {cardinality="1", is_alternate="False", is_primary="True"} ! dimethylallyl diphosphate relationship: part_of UPa:ULS00042 {cardinality="1", order="1"} ! dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate [Term] id: UPa:UER00106 name: N(2)-acetyl-L-ornithine from L-glutamate: step 1/4 namespace: enzymatic_reaction def: "1 L-glutamate + 1 acetyl-CoA => 1 CoA + 1 N-acetyl-L-glutamate." [] xref: EC:2.3.1.1 xref: GO:0004042 "molecular_function:acetyl-CoA:L-glutamate N-acetyltransferase activity" relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: part_of UPa:ULS00043 {cardinality="1", order="1"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00107 name: N(2)-acetyl-L-ornithine from L-glutamate: step 2/4 namespace: enzymatic_reaction def: "1 ATP + 1 N-acetyl-L-glutamate => 1 ADP + 1 N-acetyl-L-glutamyl 5-phosphate." [] xref: EC:2.7.2.8 xref: GO:0003991 "molecular_function:acetylglutamate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04133 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamyl 5-phosphate relationship: part_of UPa:ULS00043 {cardinality="1", order="2"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00108 name: N(2)-acetyl-L-ornithine from L-glutamate: step 3/4 namespace: enzymatic_reaction def: "1 H(+) + 1 N-acetyl-L-glutamyl 5-phosphate + 1 NADPH => 1 N-acetyl-L-glutamate 5-semialdehyde + 1 NADP(+) + 1 phosphate." [] xref: EC:1.2.1.38 xref: GO:0003942 "molecular_function:N-acetyl-gamma-glutamyl-phosphate reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC04133 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamyl 5-phosphate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01250 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00043 {cardinality="1", order="3"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00109 name: N(2)-acetyl-L-ornithine from L-glutamate: step 4/4 namespace: enzymatic_reaction def: "1 L-glutamate + 1 N-acetyl-L-glutamate 5-semialdehyde => 1 2-oxoglutarate + 1 N(2)-acetyl-L-ornithine." [] xref: EC:2.6.1.11 xref: GO:0003992 "molecular_function:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC01250 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: part_of UPa:ULS00043 {cardinality="1", order="4"} ! N(2)-acetyl-L-ornithine from L-glutamate [Term] id: UPa:UER00110 name: L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 N(2)-acetyl-L-ornithine => 1 L-ornithine + 1 acetate." [] xref: EC:3.5.1.16 xref: GO:0008777 "molecular_function:acetylornithine deacetylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: part_of UPa:ULS00044 {cardinality="1", order="1"} ! L-ornithine from N(2)-acetyl-L-ornithine (linear) [Term] id: UPa:UER00111 name: L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1 namespace: enzymatic_reaction def: "1 L-glutamate + 1 N(2)-acetyl-L-ornithine => 1 L-ornithine + 1 N-acetyl-L-glutamate." [] xref: EC:2.3.1.35 xref: GO:0004358 "molecular_function:glutamate N-acetyltransferase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00437 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-acetyl-L-ornithine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00624 {cardinality="1", is_alternate="False", is_primary="True"} ! N-acetyl-L-glutamate relationship: part_of UPa:ULS00045 {cardinality="1", order="1"} ! L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic) [Term] id: UPa:UER00112 name: L-arginine from L-ornithine and carbamoyl phosphate: step 1/3 namespace: enzymatic_reaction def: "1 L-ornithine + 1 carbamoyl phosphate => 1 L-citrulline + 1 phosphate." [] xref: EC:2.1.3.3 xref: GO:0004585 "molecular_function:ornithine carbamoyltransferase activity" relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: part_of UPa:ULS00046 {cardinality="1", order="1"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00113 name: L-arginine from L-ornithine and carbamoyl phosphate: step 2/3 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 L-citrulline => 1 (N(omega)-L-arginino)succinate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.4.5 xref: GO:0004055 "molecular_function:argininosuccinate synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:ULS00046 {cardinality="1", order="2"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00114 name: L-arginine from L-ornithine and carbamoyl phosphate: step 3/3 namespace: enzymatic_reaction def: "1 (N(omega)-L-arginino)succinate => 1 L-arginine + 1 fumarate." [] xref: EC:4.3.2.1 xref: GO:0004056 "molecular_function:argininosuccinate lyase activity" relationship: has_input_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: part_of UPa:ULS00046 {cardinality="1", order="3"} ! L-arginine from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00115 name: (S)-dihydroorotate from bicarbonate: step 1/3 namespace: enzymatic_reaction def: "2 ATP + 1 H(2)O + 1 L-glutamine + 1 bicarbonate => 2 ADP + 1 L-glutamate + 1 carbamoyl phosphate + 1 phosphate." [] xref: EC:6.3.5.5 xref: GO:0004088 "molecular_function:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="True"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: part_of UPa:ULS00478 {cardinality="1", order="1"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00116 name: (S)-dihydroorotate from bicarbonate: step 2/3 namespace: enzymatic_reaction def: "1 L-aspartate + 1 carbamoyl phosphate => 1 N-carbamoyl-L-aspartate + 1 phosphate." [] xref: EC:2.1.3.2 xref: GO:0004070 "molecular_function:aspartate carbamoyltransferase activity" relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00438 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoyl-L-aspartate relationship: part_of UPa:ULS00478 {cardinality="1", order="2"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00117 name: (S)-dihydroorotate from bicarbonate: step 3/3 namespace: enzymatic_reaction def: "1 N-carbamoyl-L-aspartate => 1 (S)-dihydroorotate + 1 H(2)O." [] xref: EC:3.5.2.3 xref: GO:0004151 "molecular_function:dihydroorotase activity" relationship: has_input_compound UPa:UPC00438 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoyl-L-aspartate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: part_of UPa:ULS00478 {cardinality="1", order="3"} ! (S)-dihydroorotate from bicarbonate [Term] id: UPa:UER00118 name: orotate from (S)-dihydroorotate (O2 route): step 1/1 namespace: enzymatic_reaction def: "1 (S)-dihydroorotate + 1 fumarate => 1 orotate + 1 succinate." [] xref: EC:1.3.98.1 xref: GO:0004158 "molecular_function:dihydroorotate oxidase activity" xref: GO:1990663 "molecular_function:dihydroorotate dehydrogenase (fumarate) activity" relationship: has_input_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: has_input_compound UPa:UPC00337 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-dihydroorotate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: part_of UPa:ULS00479 {cardinality="1", order="1"} ! orotate from (S)-dihydroorotate (O2 route) [Term] id: UPa:UER00119 name: UMP from orotate: step 1/2 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 orotate => 1 diphosphate + 1 orotidine 5'-phosphate." [] xref: EC:2.4.2.10 xref: GO:0004588 "molecular_function:orotate phosphoribosyltransferase activity" relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="False"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_input_compound UPa:UPC00295 {cardinality="1", is_alternate="False", is_primary="True"} ! orotate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC01103 {cardinality="1", is_alternate="False", is_primary="True"} ! orotidine 5'-phosphate relationship: part_of UPa:ULS00482 {cardinality="1", order="1"} ! UMP from orotate [Term] id: UPa:UER00120 name: UMP from orotate: step 2/2 namespace: enzymatic_reaction def: "1 orotidine 5'-phosphate => 1 CO(2) + 1 UMP." [] xref: EC:4.1.1.23 xref: GO:0004590 "molecular_function:orotidine-5'-phosphate decarboxylase activity" relationship: has_input_compound UPa:UPC01103 {cardinality="1", is_alternate="False", is_primary="True"} ! orotidine 5'-phosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: part_of UPa:ULS00482 {cardinality="1", order="2"} ! UMP from orotate [Term] id: UPa:UER00121 name: L-ectoine from L-aspartate 4-semialdehyde: step 1/3 namespace: enzymatic_reaction def: "1 L-aspartate 4-semialdehyde + 1 L-glutamate => 1 2-oxoglutarate + 1 L-2,4-diaminobutanoate." [] xref: EC:2.6.1.76 xref: GO:0045303 "molecular_function:diaminobutyrate-2-oxoglutarate transaminase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00441 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate 4-semialdehyde relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: part_of UPa:ULS00048 {cardinality="1", order="1"} ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00122 name: L-ectoine from L-aspartate 4-semialdehyde: step 2/3 namespace: enzymatic_reaction def: "1 L-2,4-diaminobutanoate + 1 acetyl-CoA => 1 CoA + 1 N(4)-acetyl-L-2,4-diaminobutyric acid." [] xref: EC:2.3.1.178 xref: GO:0033816 "molecular_function:diaminobutyrate acetyltransferase activity" relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC03283 {cardinality="1", is_alternate="False", is_primary="True"} ! L-2,4-diaminobutanoate relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC06442 {cardinality="1", is_alternate="False", is_primary="True"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: part_of UPa:ULS00048 {cardinality="1", order="2"} ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00123 name: L-ectoine from L-aspartate 4-semialdehyde: step 3/3 namespace: enzymatic_reaction def: "1 N(4)-acetyl-L-2,4-diaminobutyric acid => 1 H(2)O + 1 L-ectoine." [] xref: EC:4.2.1.108 xref: GO:0033990 "molecular_function:ectoine synthase activity" relationship: has_input_compound UPa:UPC06442 {cardinality="1", is_alternate="False", is_primary="True"} ! N(4)-acetyl-L-2,4-diaminobutyric acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC06231 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ectoine relationship: part_of UPa:ULS00048 {cardinality="1", order="3"} ! L-ectoine from L-aspartate 4-semialdehyde [Term] id: UPa:UER00124 name: N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2 namespace: enzymatic_reaction def: "1 5-phospho-alpha-D-ribose 1-diphosphate + 1 H(2)O + 1 L-glutamine => 1 5-phospho-beta-D-ribosylamine + 1 L-glutamate + 1 diphosphate." [] xref: EC:2.4.2.14 xref: GO:0004044 "molecular_function:amidophosphoribosyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC03090 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-beta-D-ribosylamine relationship: part_of UPa:ULS00050 {cardinality="1", order="1"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00125 name: N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2 namespace: enzymatic_reaction def: "1 5-phospho-beta-D-ribosylamine + 1 ATP + 1 glycine => 1 ADP + 1 N(1)-(5-phospho-D-ribosyl)glycinamide + 1 phosphate." [] xref: EC:6.3.4.13 xref: GO:0004637 "molecular_function:phosphoribosylamine-glycine ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="False"} ! glycine relationship: has_input_compound UPa:UPC03090 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-beta-D-ribosylamine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00050 {cardinality="1", order="2"} ! N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate [Term] id: UPa:UER00126 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 N(1)-(5-phospho-D-ribosyl)glycinamide => 1 5,6,7,8-tetrahydrofolate + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide." [] xref: EC:2.1.2.2 xref: GO:0004644 "molecular_function:phosphoribosylglycinamide formyltransferase activity" relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="False"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00051 {cardinality="1", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route) [Term] id: UPa:UER00127 name: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 N(1)-(5-phospho-D-ribosyl)glycinamide + 1 formate => 1 ADP + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + 1 phosphate." [] xref: EC:2.1.2 xref: GO:0016742 "molecular_function:hydroxymethyl-, formyl- and related transferase activity" xref: GO:0030407 "molecular_function:formimidoyltransferase activity" xref: GO:0043815 "molecular_function:phosphoribosylglycinamide formyltransferase 2 activity" xref: GO:0044685 "molecular_function:tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_input_compound UPa:UPC03838 {cardinality="1", is_alternate="False", is_primary="True"} ! N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: part_of UPa:ULS00052 {cardinality="1", order="1"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route) [Term] id: UPa:UER00128 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-glutamine + 1 N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide => 1 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + 1 ADP + 1 L-glutamate + 1 phosphate." [] xref: EC:6.3.5.3 xref: GO:0004642 "molecular_function:phosphoribosylformylglycinamidine synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC04376 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC04640 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: part_of UPa:ULS00470 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [Term] id: UPa:UER00129 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2 namespace: enzymatic_reaction def: "1 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine + 1 ATP => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole + 1 ADP + 1 phosphate." [] xref: EC:6.3.3.1 xref: GO:0004641 "molecular_function:phosphoribosylformylglycinamidine cyclo-ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04640 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: part_of UPa:ULS00470 {cardinality="1", order="2"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide [Term] id: UPa:UER00130 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole + 1 CO(2) => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [] xref: EC:4.1.1.21 xref: GO:0004638 "molecular_function:phosphoribosylaminoimidazole carboxylase activity" relationship: has_input_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_input_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC04751 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: part_of UPa:ULS00471 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route) [Term] id: UPa:UER00131 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 1 ATP + 1 L-aspartate => 1 (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid + 1 ADP + 1 phosphate." [] xref: EC:6.3.2.6 xref: GO:0004639 "molecular_function:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="False"} ! L-aspartate relationship: has_input_compound UPa:UPC04751 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04823 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: part_of UPa:ULS00473 {cardinality="1", order="1"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [Term] id: UPa:UER00132 name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2 namespace: enzymatic_reaction def: "1 (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid => 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 fumarate." [] xref: EC:4.3.2.2 xref: GO:0004018 "molecular_function:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" xref: GO:0070626 "molecular_function:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" relationship: has_input_compound UPa:UPC04823 {cardinality="1", is_alternate="False", is_primary="True"} ! (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="False"} ! fumarate relationship: has_output_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00473 {cardinality="1", order="2"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [Term] id: UPa:UER00133 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => 1 5,6,7,8-tetrahydrofolate + 1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [] xref: EC:2.1.2.3 xref: GO:0004643 "molecular_function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity" relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="False"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_input_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00054 {cardinality="1", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route) [Term] id: UPa:UER00134 name: 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 ATP + 1 formate => 1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 1 ADP + 1 phosphate." [] xref: EC:6.3.4 xref: GO:0016979 "molecular_function:lipoate-protein ligase activity" xref: GO:0018271 "molecular_function:biotin-protein ligase activity" xref: GO:0032267 "molecular_function:tRNA(Ile)-lysidine synthase activity" xref: GO:0071734 "molecular_function:biotin-[pyruvate-carboxylase] ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_input_compound UPa:UPC04677 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: part_of UPa:ULS00055 {cardinality="1", order="1"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route) [Term] id: UPa:UER00135 name: IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1 namespace: enzymatic_reaction def: "1 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => 1 H(2)O + 1 IMP." [] xref: EC:3.5.4.10 xref: GO:0003937 "molecular_function:IMP cyclohydrolase activity" relationship: has_input_compound UPa:UPC04734 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: part_of UPa:ULS00056 {cardinality="1", order="1"} ! IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [Term] id: UPa:UER00136 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 1/3 namespace: enzymatic_reaction def: "1 5-amino-1-(5-phospho-D-ribosyl)imidazole => 1 4-amino-5-hydroxymethyl-2-methylpyrimidine." [] relationship: has_input_compound UPa:UPC03373 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-amino-1-(5-phospho-D-ribosyl)imidazole relationship: has_output_compound UPa:UPC01279 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: part_of UPa:ULS00057 {cardinality="1", order="1"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00137 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3 namespace: enzymatic_reaction def: "1 4-amino-5-hydroxymethyl-2-methylpyrimidine + 1 ATP => 1 4-amino-2-methyl-5-phosphomethylpyrimidine + 1 ADP." [] xref: EC:2.7.1.49 xref: GO:0008902 "molecular_function:hydroxymethylpyrimidine kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01279 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-5-hydroxymethyl-2-methylpyrimidine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04556 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: part_of UPa:ULS00057 {cardinality="1", order="2"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00138 name: 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3 namespace: enzymatic_reaction def: "1 4-amino-2-methyl-5-phosphomethylpyrimidine + 1 ATP => 1 4-amino-2-methyl-5-diphosphomethylpyrimidine + 1 ADP." [] xref: EC:2.7.4.7 xref: GO:0008972 "molecular_function:phosphomethylpyrimidine kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04556 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-phosphomethylpyrimidine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04752 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: part_of UPa:ULS00057 {cardinality="1", order="3"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole [Term] id: UPa:UER00139 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1 namespace: enzymatic_reaction def: "1 5-(2-hydroxyethyl)-4-methylthiazole + 1 ATP => 1 4-methyl-5-(2-phosphoethyl)-thiazole + 1 ADP." [] xref: EC:2.7.1.50 xref: GO:0004417 "molecular_function:hydroxyethylthiazole kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC04294 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-(2-hydroxyethyl)-4-methylthiazole relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:ULS00058 {cardinality="1", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole [Term] id: UPa:UER00140 name: 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate: step 1/1 namespace: enzymatic_reaction def: "1 1-deoxy-D-xylulose 5-phosphate => 1 4-methyl-5-(2-phosphoethyl)-thiazole." [] relationship: has_input_compound UPa:UPC11437 {cardinality="1", is_alternate="False", is_primary="True"} ! 1-deoxy-D-xylulose 5-phosphate relationship: has_output_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: part_of UPa:ULS00059 {cardinality="1", order="1"} ! 4-methyl-5-(2-phosphoethyl)-thiazole from 1-deoxy-D-xylulose 5-phosphate [Term] id: UPa:UER00141 name: thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1 namespace: enzymatic_reaction def: "1 4-amino-2-methyl-5-diphosphomethylpyrimidine + 1 4-methyl-5-(2-phosphoethyl)-thiazole => 1 diphosphate + 1 thiamine phosphate." [] xref: EC:2.5.1.3 xref: GO:0004789 "molecular_function:thiamine-phosphate diphosphorylase activity" relationship: has_input_compound UPa:UPC04327 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-methyl-5-(2-phosphoethyl)-thiazole relationship: has_input_compound UPa:UPC04752 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-2-methyl-5-diphosphomethylpyrimidine relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC01081 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine phosphate relationship: part_of UPa:ULS00060 {cardinality="1", order="1"} ! thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole [Term] id: UPa:UER00142 name: thiamine diphosphate from thiamine phosphate: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 thiamine phosphate => 1 ADP + 1 thiamine diphosphate." [] xref: EC:2.7.4.16 xref: GO:0009030 "molecular_function:thiamine-phosphate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01081 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00068 {cardinality="1", is_alternate="False", is_primary="True"} ! thiamine diphosphate relationship: part_of UPa:ULS00283 {cardinality="1", order="1"} ! thiamine diphosphate from thiamine phosphate [Term] id: UPa:UER00143 name: acetyl-CoA from myo-inositol: step 1/7 namespace: enzymatic_reaction def: "1 NAD(+) + 1 myo-inositol => 1 H(+) + 1 NADH + 1 scyllo-inosose." [] xref: EC:1.1.1.18 xref: GO:0050112 "molecular_function:inositol 2-dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00137 {cardinality="1", is_alternate="False", is_primary="True"} ! myo-inositol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00691 {cardinality="1", is_alternate="False", is_primary="True"} ! scyllo-inosose relationship: part_of UPa:ULS00061 {cardinality="1", order="1"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00144 name: acetyl-CoA from myo-inositol: step 2/7 namespace: enzymatic_reaction def: "1 scyllo-inosose => 1 3D-3,5/4-trihydroxycyclohexane-1,2-dione + 1 H(2)O." [] xref: EC:4.2.1.44 xref: GO:0050114 "molecular_function:myo-inosose-2 dehydratase activity" relationship: has_input_compound UPa:UPC00691 {cardinality="1", is_alternate="False", is_primary="True"} ! scyllo-inosose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC04287 {cardinality="1", is_alternate="False", is_primary="True"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: part_of UPa:ULS00061 {cardinality="1", order="2"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00145 name: acetyl-CoA from myo-inositol: step 3/7 namespace: enzymatic_reaction def: "1 3D-3,5/4-trihydroxycyclohexane-1,2-dione + 1 H(2)O => 1 5-deoxy-D-glucuronic acid." [] xref: EC:3.7.1.22 relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04287 {cardinality="1", is_alternate="False", is_primary="True"} ! 3D-3,5/4-trihydroxycyclohexane-1,2-dione relationship: has_output_compound UPa:UPC16737 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-deoxy-D-glucuronic acid relationship: part_of UPa:ULS00061 {cardinality="1", order="3"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00146 name: acetyl-CoA from myo-inositol: step 5/7 namespace: enzymatic_reaction def: "1 2-deoxy-5-keto-D-gluconic acid + 1 ATP => 1 6-phospho-5-dehydro-2-deoxy-D-gluconic acid + 1 ADP." [] xref: EC:2.7.1.92 xref: GO:0047590 "molecular_function:5-dehydro-2-deoxygluconokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC06892 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-deoxy-5-keto-D-gluconic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC06893 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: part_of UPa:ULS00061 {cardinality="1", order="5"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00147 name: acetyl-CoA from myo-inositol: step 6/7 namespace: enzymatic_reaction def: "1 6-phospho-5-dehydro-2-deoxy-D-gluconic acid => 1 3-oxopropanoate + 1 glycerone phosphate." [] xref: EC:4.1.2.29 xref: GO:0047441 "molecular_function:5-dehydro-2-deoxyphosphogluconate aldolase activity" relationship: has_input_compound UPa:UPC06893 {cardinality="1", is_alternate="False", is_primary="True"} ! 6-phospho-5-dehydro-2-deoxy-D-gluconic acid relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="False"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: part_of UPa:ULS00061 {cardinality="1", order="6"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00148 name: acetyl-CoA from myo-inositol: step 7/7 namespace: enzymatic_reaction def: "3-oxopropanoate + CoA + [NAD(+) or NADP(+)] => CO(2) + H(+) + acetyl-CoA + [NADH or NADPH]." [] xref: EC:1.2.1.18 xref: EC:1.2.1.27 xref: GO:0004491 "molecular_function:methylmalonate-semialdehyde dehydrogenase (acylating) activity" xref: GO:0018478 "molecular_function:malonate-semialdehyde dehydrogenase (acetylating) activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC00222 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxopropanoate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: part_of UPa:ULS00061 {cardinality="1", order="7"} ! acetyl-CoA from myo-inositol [Term] id: UPa:UER00149 name: 4-aminobenzoate from chorismate: step 1/2 namespace: enzymatic_reaction def: "1 L-glutamine + 1 NH(3) + 1 chorismate => 1 4-amino-4-deoxychorismate + 1 L-glutamate." [] xref: EC:2.6.1.85 xref: GO:0046820 "molecular_function:4-amino-4-deoxychorismate synthase activity" relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC11355 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-4-deoxychorismate relationship: part_of UPa:ULS00062 {cardinality="1", order="1"} ! 4-aminobenzoate from chorismate [Term] id: UPa:UER00150 name: 4-aminobenzoate from chorismate: step 2/2 namespace: enzymatic_reaction def: "1 4-amino-4-deoxychorismate => 1 4-aminobenzoate + 1 pyruvate." [] xref: EC:4.1.3.38 xref: GO:0008696 "molecular_function:4-amino-4-deoxychorismate lyase activity" relationship: has_input_compound UPa:UPC11355 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-amino-4-deoxychorismate relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="False"} ! pyruvate relationship: has_output_compound UPa:UPC00568 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobenzoate relationship: part_of UPa:ULS00062 {cardinality="1", order="2"} ! 4-aminobenzoate from chorismate [Term] id: UPa:UER00151 name: 7,8-dihydroneopterin triphosphate from GTP: step 1/1 namespace: enzymatic_reaction def: "1 GTP + 1 H(2)O => 1 7,8-dihydroneopterin triphosphate + 1 formate." [] xref: EC:3.5.4.16 xref: GO:0003934 "molecular_function:GTP cyclohydrolase I activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="True"} ! GTP relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="False"} ! formate relationship: has_output_compound UPa:UPC04895 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin triphosphate relationship: part_of UPa:ULS00410 {cardinality="1", order="1"} ! 7,8-dihydroneopterin triphosphate from GTP [Term] id: UPa:UER00152 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin triphosphate + 1 H(2)O => 1 7,8-dihydroneopterin 3'-phosphate + 1 diphosphate." [] relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC04895 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin triphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC05925 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin 3'-phosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="1"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00153 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin 3'-phosphate + 1 H(2)O => 1 7,8-dihydroneopterin + 1 phosphate." [] xref: EC:3.6.1 xref: GO:0004787 "molecular_function:thiamine-pyrophosphatase activity" xref: GO:0008413 "molecular_function:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity" xref: GO:0008758 "molecular_function:UDP-2,3-diacylglucosamine hydrolase activity" xref: GO:0008796 "molecular_function:bis(5'-nucleosyl)-tetraphosphatase activity" xref: GO:0008828 "molecular_function:dATP pyrophosphohydrolase activity" xref: GO:0016462 "molecular_function:pyrophosphatase activity" xref: GO:0016818 "molecular_function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" xref: GO:0019176 "molecular_function:dihydroneopterin monophosphate phosphatase activity" xref: GO:0019177 "molecular_function:dihydroneopterin triphosphate pyrophosphohydrolase activity" xref: GO:0035870 "molecular_function:dITP diphosphatase activity" xref: GO:0036218 "molecular_function:dTTP diphosphatase activity" xref: GO:0036222 "molecular_function:XTP diphosphatase activity" xref: GO:0043141 "molecular_function:ATP-dependent 5'-3' DNA helicase activity" xref: GO:0044606 "molecular_function:phosphocholine hydrolase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC05925 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin 3'-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC04874 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin relationship: part_of UPa:ULS00063 {cardinality="1", order="2"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00154 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4 namespace: enzymatic_reaction def: "1 7,8-dihydroneopterin => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 glycolaldehyde." [] xref: EC:4.1.2.25 xref: GO:0004150 "molecular_function:dihydroneopterin aldolase activity" relationship: has_input_compound UPa:UPC04874 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydroneopterin relationship: has_output_compound UPa:UPC00266 {cardinality="1", is_alternate="False", is_primary="False"} ! glycolaldehyde relationship: has_output_compound UPa:UPC01300 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: part_of UPa:ULS00063 {cardinality="1", order="3"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00155 name: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 namespace: enzymatic_reaction def: "1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 ATP => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 AMP." [] xref: EC:2.7.6.3 xref: GO:0003848 "molecular_function:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01300 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC04807 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: part_of UPa:ULS00063 {cardinality="1", order="4"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate [Term] id: UPa:UER00156 name: 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2 namespace: enzymatic_reaction def: "1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 4-aminobenzoate => 1 7,8-dihydropteroate + 1 diphosphate." [] xref: EC:2.5.1.15 xref: GO:0004156 "molecular_function:dihydropteroate synthase activity" relationship: has_input_compound UPa:UPC00568 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobenzoate relationship: has_input_compound UPa:UPC04807 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00921 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydropteroate relationship: part_of UPa:ULS00064 {cardinality="1", order="1"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate [Term] id: UPa:UER00157 name: 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2 namespace: enzymatic_reaction def: "1 7,8-dihydropteroate + 1 ATP + 1 L-glutamate => 1 7,8-dihydrofolate + 1 ADP + 1 phosphate." [] xref: EC:6.3.2.12 xref: GO:0008841 "molecular_function:dihydrofolate synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC00921 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydropteroate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00415 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydrofolate relationship: part_of UPa:ULS00064 {cardinality="1", order="2"} ! 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate [Term] id: UPa:UER00158 name: 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1 namespace: enzymatic_reaction def: "1 7,8-dihydrofolate + 1 H(+) + 1 NADPH => 1 5,6,7,8-tetrahydrofolate + 1 NADP(+)." [] xref: EC:1.5.1.3 xref: GO:0004146 "molecular_function:dihydrofolate reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00415 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-dihydrofolate relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="True"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00411 {cardinality="1", order="1"} ! 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate [Term] id: UPa:UER00159 name: 8-amino-7-oxononanoate from pimeloyl-CoA: step 1/1 namespace: enzymatic_reaction def: "1 L-alanine + 1 pimeloyl-CoA => 1 8-amino-7-oxononanoate + 1 CO(2) + 1 CoA." [] xref: EC:2.3.1.47 xref: GO:0008710 "molecular_function:8-amino-7-oxononanoate synthase activity" relationship: has_input_compound UPa:UPC00041 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alanine relationship: has_input_compound UPa:UPC01063 {cardinality="1", is_alternate="False", is_primary="True"} ! pimeloyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC01092 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-amino-7-oxononanoate relationship: part_of UPa:ULS00474 {cardinality="1", order="1"} ! 8-amino-7-oxononanoate from pimeloyl-CoA [Term] id: UPa:UER00160 name: 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1 namespace: enzymatic_reaction def: "1 8-amino-7-oxononanoate + 1 S-adenosyl-L-methionine => 1 7,8-diaminononanoate + 1 S-adenosyl-4-methylthio-2-oxobutanoic acid." [] xref: EC:2.6.1.62 xref: GO:0004015 "molecular_function:adenosylmethionine-8-amino-7-oxononanoate transaminase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01092 {cardinality="1", is_alternate="False", is_primary="True"} ! 8-amino-7-oxononanoate relationship: has_output_compound UPa:UPC01037 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC04425 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-4-methylthio-2-oxobutanoic acid relationship: part_of UPa:ULS00475 {cardinality="1", order="1"} ! 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route) [Term] id: UPa:UER00161 name: biotin from 7,8-diaminononanoate: step 1/2 namespace: enzymatic_reaction def: "1 7,8-diaminononanoate + 1 ATP + 1 CO(2) => 1 ADP + 1 dethiobiotin + 1 phosphate." [] xref: EC:6.3.3.3 xref: GO:0004141 "molecular_function:dethiobiotin synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_input_compound UPa:UPC01037 {cardinality="1", is_alternate="False", is_primary="True"} ! 7,8-diaminononanoate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC01909 {cardinality="1", is_alternate="False", is_primary="True"} ! dethiobiotin relationship: part_of UPa:ULS00477 {cardinality="1", order="1"} ! biotin from 7,8-diaminononanoate [Term] id: UPa:UER00162 name: biotin from 7,8-diaminononanoate: step 2/2 namespace: enzymatic_reaction def: "2 H(+) + 2 S-adenosyl-L-methionine + 1 dethiobiotin + 2 e- + 1 sulfur donor => 2 5'-deoxyadenosine + 2 L-methionine + 1 biotin." [] xref: EC:2.8.1.6 xref: GO:0004076 "molecular_function:biotin synthase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01909 {cardinality="1", is_alternate="False", is_primary="True"} ! dethiobiotin relationship: has_input_compound UPa:UPC05359 {cardinality="1", is_alternate="False", is_primary="False"} ! e- relationship: has_input_compound UPa:UPC17023 {cardinality="1", is_alternate="False", is_primary="False"} ! sulfur donor relationship: has_output_compound UPa:UPC00073 {cardinality="1", is_alternate="False", is_primary="False"} ! L-methionine relationship: has_output_compound UPa:UPC00120 {cardinality="1", is_alternate="False", is_primary="True"} ! biotin relationship: has_output_compound UPa:UPC05198 {cardinality="1", is_alternate="False", is_primary="False"} ! 5'-deoxyadenosine relationship: part_of UPa:ULS00477 {cardinality="1", order="2"} ! biotin from 7,8-diaminononanoate [Term] id: UPa:UER00163 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7 namespace: enzymatic_reaction def: "1 chorismate => 1 isochorismate." [] xref: EC:5.4.4.2 xref: GO:0008909 "molecular_function:isochorismate synthase activity" relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_output_compound UPa:UPC00885 {cardinality="1", is_alternate="False", is_primary="True"} ! isochorismate relationship: part_of UPa:ULS00509 {cardinality="1", order="1"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00164 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 isochorismate => 1 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid + 1 CO(2)." [] xref: EC:2.2.1.9 xref: GO:0070204 "molecular_function:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity" relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00885 {cardinality="1", is_alternate="False", is_primary="True"} ! isochorismate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC16519 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid relationship: part_of UPa:ULS00509 {cardinality="1", order="2"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00165 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7 namespace: enzymatic_reaction def: "1 (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid => 1 2-succinylbenzoate + 1 H(2)O." [] xref: EC:4.2.1.113 relationship: has_input_compound UPa:UPC05817 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02730 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoate relationship: part_of UPa:ULS00509 {cardinality="1", order="4"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00166 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7 namespace: enzymatic_reaction def: "1 2-succinylbenzoate + 1 ATP + 1 CoA => 1 2-succinylbenzoyl-CoA + 1 AMP + 1 diphosphate." [] xref: EC:6.2.1.26 xref: GO:0008756 "molecular_function:o-succinylbenzoate-CoA ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC02730 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC03160 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoyl-CoA relationship: part_of UPa:ULS00509 {cardinality="1", order="5"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00167 name: 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7 namespace: enzymatic_reaction def: "1 2-succinylbenzoyl-CoA => 1 1,4-dihydroxy-2-naphthoyl-CoA + 1 H(2)O." [] xref: EC:4.1.3.36 xref: GO:0008935 "molecular_function:1,4-dihydroxy-2-naphthoyl-CoA synthase activity" relationship: has_input_compound UPa:UPC03160 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-succinylbenzoyl-CoA relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC15547 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoyl-CoA relationship: part_of UPa:ULS00509 {cardinality="1", order="6"} ! 1,4-dihydroxy-2-naphthoate from chorismate [Term] id: UPa:UER00168 name: menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2 namespace: enzymatic_reaction def: "1 1,4-dihydroxy-2-naphthoate + 1 all-trans-polyprenyl diphosphate => 1 CO(2) + 1 demethylmenaquinol + 1 diphosphate." [] xref: EC:2.5.1.74 relationship: has_input_compound UPa:UPC03657 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,4-dihydroxy-2-naphthoate relationship: has_input_compound UPa:UPC05847 {cardinality="1", is_alternate="False", is_primary="False"} ! all-trans-polyprenyl diphosphate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC19847 {cardinality="1", is_alternate="False", is_primary="True"} ! demethylmenaquinol relationship: part_of UPa:ULS00510 {cardinality="1", order="1"} ! menaquinol from 1,4-dihydroxy-2-naphthoate [Term] id: UPa:UER00169 name: menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 demethylmenaquinol => 1 S-adenosyl-L-homocysteine + 1 menaquinol." [] xref: EC:2.1.1.163 relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC19847 {cardinality="1", is_alternate="False", is_primary="True"} ! demethylmenaquinol relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC05819 {cardinality="1", is_alternate="False", is_primary="True"} ! menaquinol relationship: part_of UPa:ULS00510 {cardinality="1", order="2"} ! menaquinol from 1,4-dihydroxy-2-naphthoate [Term] id: UPa:UER00170 name: formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1 namespace: enzymatic_reaction def: "1 10-formyl-5,6,7,8-tetrahydrofolate + 1 H(2)O => 1 5,6,7,8-tetrahydrofolate + 1 formate." [] xref: EC:3.5.1.10 xref: GO:0008864 "molecular_function:formyltetrahydrofolate deformylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00234 {cardinality="1", is_alternate="False", is_primary="True"} ! 10-formyl-5,6,7,8-tetrahydrofolate relationship: has_output_compound UPa:UPC00058 {cardinality="1", is_alternate="False", is_primary="True"} ! formate relationship: has_output_compound UPa:UPC00101 {cardinality="1", is_alternate="False", is_primary="False"} ! 5,6,7,8-tetrahydrofolate relationship: part_of UPa:ULS00067 {cardinality="1", order="1"} ! formate from 10-formyl-5,6,7,8-tetrahydrofolate [Term] id: UPa:UER00171 name: carbamoyl phosphate from bicarbonate: step 1/1 namespace: enzymatic_reaction def: "2 ATP + 1 H(2)O + 1 L-glutamine + 1 bicarbonate => 2 ADP + 1 L-glutamate + 1 carbamoyl phosphate + 1 phosphate." [] xref: EC:6.3.5.5 xref: GO:0004088 "molecular_function:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00288 {cardinality="1", is_alternate="False", is_primary="True"} ! bicarbonate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: part_of UPa:ULS00068 {cardinality="1", order="1"} ! carbamoyl phosphate from bicarbonate [Term] id: UPa:UER00172 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 D-ribose 5-phosphate => 1 5-phospho-alpha-D-ribose 1-diphosphate + 1 AMP." [] xref: EC:2.7.6.1 xref: GO:0004749 "molecular_function:ribose phosphate diphosphokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00070 {cardinality="1", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I) [Term] id: UPa:UER00173 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3 namespace: enzymatic_reaction def: "1 D-ribose 5-phosphate => 1 alpha-D-ribose 1-phosphate." [] xref: EC:5.4.2.7 xref: GO:0008973 "molecular_function:phosphopentomutase activity" relationship: has_input_compound UPa:UPC00117 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 5-phosphate relationship: has_output_compound UPa:UPC00620 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-ribose 1-phosphate relationship: part_of UPa:ULS00071 {cardinality="1", order="1"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00174 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 2/3 namespace: enzymatic_reaction def: "1 alpha-D-ribose 1-phosphate => 1 D-ribose 1,5-bisphosphate." [] relationship: has_input_compound UPa:UPC00620 {cardinality="1", is_alternate="False", is_primary="True"} ! alpha-D-ribose 1-phosphate relationship: has_output_compound UPa:UPC01151 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 1,5-bisphosphate relationship: part_of UPa:ULS00071 {cardinality="1", order="2"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00175 name: 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3 namespace: enzymatic_reaction def: "1 ATP + 1 D-ribose 1,5-bisphosphate => 1 5-phospho-alpha-D-ribose 1-diphosphate + 1 ADP." [] xref: EC:2.7.4.23 xref: GO:0033863 "molecular_function:ribose 1,5-bisphosphate phosphokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC01151 {cardinality="1", is_alternate="False", is_primary="True"} ! D-ribose 1,5-bisphosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00119 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-phospho-alpha-D-ribose 1-diphosphate relationship: part_of UPa:ULS00071 {cardinality="1", order="3"} ! 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II) [Term] id: UPa:UER00176 name: 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1 namespace: enzymatic_reaction def: "1 D-quinate + 1 NAD(+) => 1 3-dehydroquinate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.24 xref: GO:0030266 "molecular_function:quinate 3-dehydrogenase (NAD+) activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00296 {cardinality="1", is_alternate="False", is_primary="True"} ! D-quinate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: part_of UPa:ULS00072 {cardinality="1", order="1"} ! 3-dehydroquinate from D-quinate (NAD(+) route) [Term] id: UPa:UER00177 name: 3-dehydroquinate from D-quinate (PQQ route): step 1/1 namespace: enzymatic_reaction def: "1 D-quinate + 1 pyrroloquinoline quinone => 1 3-dehydroquinate + 1 pyrroloquinoline quinol." [] xref: EC:1.1.5.8 xref: GO:0047519 "molecular_function:quinate dehydrogenase (quinone) activity" relationship: has_input_compound UPa:UPC00113 {cardinality="1", is_alternate="False", is_primary="False"} ! pyrroloquinoline quinone relationship: has_input_compound UPa:UPC00296 {cardinality="1", is_alternate="False", is_primary="True"} ! D-quinate relationship: has_output_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC01359 {cardinality="1", is_alternate="False", is_primary="False"} ! pyrroloquinoline quinol relationship: part_of UPa:ULS00073 {cardinality="1", order="1"} ! 3-dehydroquinate from D-quinate (PQQ route) [Term] id: UPa:UER00178 name: 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2 namespace: enzymatic_reaction def: "1 3-dehydroquinate => 1 3-dehydroshikimate + 1 H(2)O." [] xref: EC:4.2.1.10 xref: GO:0003855 "molecular_function:3-dehydroquinate dehydratase activity" relationship: has_input_compound UPa:UPC00944 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroquinate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: part_of UPa:ULS00074 {cardinality="1", order="1"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate [Term] id: UPa:UER00179 name: 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2 namespace: enzymatic_reaction def: "1 3-dehydroshikimate => 1 3,4-dihydroxybenzoate + 1 H(2)O." [] xref: EC:4.2.1.118 relationship: has_input_compound UPa:UPC02637 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-dehydroshikimate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00074 {cardinality="1", order="2"} ! 3,4-dihydroxybenzoate from 3-dehydroquinate [Term] id: UPa:UER00180 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-glucose => 1 ADP + 1 D-glucose 6-phosphate." [] xref: EC:2.7.1.2 xref: GO:0004340 "molecular_function:glucokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00031 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00181 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4 namespace: enzymatic_reaction def: "1 D-glucose 6-phosphate => 1 D-fructose 6-phosphate." [] xref: EC:5.3.1.9 xref: GO:0004347 "molecular_function:glucose-6-phosphate isomerase activity" relationship: has_input_compound UPa:UPC00092 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glucose 6-phosphate relationship: has_output_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="2"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00182 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4 namespace: enzymatic_reaction def: "1 ATP + 1 D-fructose 6-phosphate => 1 ADP + 1 D-fructose 1,6-bisphosphate." [] xref: EC:2.7.1.11 xref: GO:0003872 "molecular_function:6-phosphofructokinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00085 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 6-phosphate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00354 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 1,6-bisphosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="3"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00183 name: D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4 namespace: enzymatic_reaction def: "1 D-fructose 1,6-bisphosphate => 1 D-glyceraldehyde 3-phosphate + 1 glycerone phosphate." [] xref: EC:4.1.2.13 xref: GO:0004332 "molecular_function:fructose-bisphosphate aldolase activity" relationship: has_input_compound UPa:UPC00354 {cardinality="1", is_alternate="False", is_primary="True"} ! D-fructose 1,6-bisphosphate relationship: has_output_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00075 {cardinality="1", order="4"} ! D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose [Term] id: UPa:UER00184 name: pyruvate from D-glyceraldehyde 3-phosphate: step 1/5 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 NAD(+) + 1 phosphate => 1 3-phospho-D-glyceroyl phosphate + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.12 xref: GO:0004365 "molecular_function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00236 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glyceroyl phosphate relationship: part_of UPa:ULS00077 {cardinality="1", order="1"} ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00185 name: pyruvate from D-glyceraldehyde 3-phosphate: step 2/5 namespace: enzymatic_reaction def: "1 3-phospho-D-glyceroyl phosphate + 1 ADP => 1 3-phospho-D-glycerate + 1 ATP." [] xref: EC:2.7.2.3 xref: GO:0004618 "molecular_function:phosphoglycerate kinase activity" relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00236 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glyceroyl phosphate relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: part_of UPa:ULS00077 {cardinality="1", order="2"} ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00186 name: pyruvate from D-glyceraldehyde 3-phosphate: step 3/5 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate => 1 2-phospho-D-glycerate." [] xref: EC:5.4.2.11 xref: GO:0004619 "molecular_function:phosphoglycerate mutase activity" relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00631 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phospho-D-glycerate relationship: part_of UPa:ULS00077 {cardinality="1", order="3"} ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00187 name: pyruvate from D-glyceraldehyde 3-phosphate: step 4/5 namespace: enzymatic_reaction def: "1 2-phospho-D-glycerate => 1 H(2)O + 1 phosphoenolpyruvate." [] xref: EC:4.2.1.11 xref: GO:0004634 "molecular_function:phosphopyruvate hydratase activity" relationship: has_input_compound UPa:UPC00631 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-phospho-D-glycerate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: part_of UPa:ULS00077 {cardinality="1", order="4"} ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00188 name: pyruvate from D-glyceraldehyde 3-phosphate: step 5/5 namespace: enzymatic_reaction def: "1 ADP + 1 phosphoenolpyruvate => 1 ATP + 1 pyruvate." [] xref: EC:2.7.1.40 xref: GO:0004743 "molecular_function:pyruvate kinase activity" relationship: has_input_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_input_compound UPa:UPC00074 {cardinality="1", is_alternate="False", is_primary="True"} ! phosphoenolpyruvate relationship: has_output_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_output_compound UPa:UPC00022 {cardinality="1", is_alternate="False", is_primary="True"} ! pyruvate relationship: part_of UPa:ULS00077 {cardinality="1", order="5"} ! pyruvate from D-glyceraldehyde 3-phosphate [Term] id: UPa:UER00189 name: D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 namespace: enzymatic_reaction def: "1 glycerone phosphate => 1 D-glyceraldehyde 3-phosphate." [] xref: EC:5.3.1.1 xref: GO:0004807 "molecular_function:triose-phosphate isomerase activity" relationship: has_input_compound UPa:UPC00111 {cardinality="1", is_alternate="False", is_primary="True"} ! glycerone phosphate relationship: has_output_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: part_of UPa:ULS00076 {cardinality="1", order="1"} ! D-glyceraldehyde 3-phosphate from glycerone phosphate [Term] id: UPa:UER00190 name: GDP-L-fucose from GDP-alpha-D-mannose: step 1/2 namespace: enzymatic_reaction def: "1 GDP-alpha-D-mannose => 1 GDP-4-dehydro-6-deoxy-D-mannose + 1 H(2)O." [] xref: EC:4.2.1.47 xref: GO:0008446 "molecular_function:GDP-mannose 4,6-dehydratase activity" relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC01222 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: part_of UPa:ULS00078 {cardinality="1", order="1"} ! GDP-L-fucose from GDP-alpha-D-mannose [Term] id: UPa:UER00191 name: GDP-L-fucose from GDP-alpha-D-mannose: step 2/2 namespace: enzymatic_reaction def: "1 GDP-4-dehydro-6-deoxy-D-mannose + 1 H(+) + 1 NADPH => 1 GDP-L-fucose + 1 NADP(+)." [] xref: EC:1.1.1.271 xref: GO:0050577 "molecular_function:GDP-L-fucose synthase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC01222 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-4-dehydro-6-deoxy-D-mannose relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00325 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-L-fucose relationship: part_of UPa:ULS00078 {cardinality="1", order="2"} ! GDP-L-fucose from GDP-alpha-D-mannose [Term] id: UPa:UER00192 name: 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate + 1 GDP-alpha-D-mannose => 1 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + 1 GDP." [] xref: EC:2.4.1.217 xref: GO:0050504 "molecular_function:mannosyl-3-phosphoglycerate synthase activity" relationship: has_input_compound UPa:UPC00096 {cardinality="1", is_alternate="False", is_primary="True"} ! GDP-alpha-D-mannose relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="False"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="False", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC11516 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: part_of UPa:ULS00079 {cardinality="1", order="1"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) [Term] id: UPa:UER00193 name: 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2 namespace: enzymatic_reaction def: "1 2-(alpha-D-mannosyl)-3-phosphoglyceric acid + 1 H(2)O => 1 2-(alpha-D-mannosyl)-D-glycerate + 1 phosphate." [] xref: EC:3.1.3.70 xref: GO:0050531 "molecular_function:mannosyl-3-phosphoglycerate phosphatase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC11516 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-3-phosphoglyceric acid relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC11544 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-(alpha-D-mannosyl)-D-glycerate relationship: part_of UPa:ULS00079 {cardinality="1", order="2"} ! 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route) [Term] id: UPa:UER00194 name: L-asparagine from L-aspartate (ammonia route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 NH(3) => 1 AMP + 1 L-asparagine + 1 diphosphate." [] xref: EC:6.3.1.1 xref: GO:0004071 "molecular_function:aspartate-ammonia ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00152 {cardinality="1", is_alternate="False", is_primary="True"} ! L-asparagine relationship: part_of UPa:ULS00080 {cardinality="1", order="1"} ! L-asparagine from L-aspartate (ammonia route) [Term] id: UPa:UER00195 name: L-asparagine from L-aspartate (L-Gln route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-aspartate + 1 L-glutamine => 1 AMP + 1 L-asparagine + 1 L-glutamate + 1 diphosphate." [] xref: EC:6.3.5.4 xref: GO:0004066 "molecular_function:asparagine synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00152 {cardinality="1", is_alternate="False", is_primary="True"} ! L-asparagine relationship: part_of UPa:ULS00081 {cardinality="1", order="1"} ! L-asparagine from L-aspartate (L-Gln route) [Term] id: UPa:UER00196 name: L-serine from 3-phospho-D-glycerate: step 1/3 namespace: enzymatic_reaction def: "1 3-phospho-D-glycerate + 1 NAD(+) => 1 3-phosphohydroxypyruvate + 1 H(+) + 1 NADH." [] xref: EC:1.1.1.95 xref: GO:0004617 "molecular_function:phosphoglycerate dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00197 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phospho-D-glycerate relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC03232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphohydroxypyruvate relationship: part_of UPa:ULS00082 {cardinality="1", order="1"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00197 name: L-serine from 3-phospho-D-glycerate: step 2/3 namespace: enzymatic_reaction def: "1 3-phosphohydroxypyruvate + 1 L-glutamate => 1 2-oxoglutarate + 1 O-phospho-L-serine." [] xref: EC:2.6.1.52 xref: GO:0004648 "molecular_function:O-phospho-L-serine:2-oxoglutarate aminotransferase activity" relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_input_compound UPa:UPC03232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-phosphohydroxypyruvate relationship: has_output_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_output_compound UPa:UPC01005 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-serine relationship: part_of UPa:ULS00082 {cardinality="1", order="2"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00198 name: L-serine from 3-phospho-D-glycerate: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 O-phospho-L-serine => 1 L-serine + 1 phosphate." [] xref: EC:3.1.3.3 xref: GO:0004647 "molecular_function:phosphoserine phosphatase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01005 {cardinality="1", is_alternate="False", is_primary="True"} ! O-phospho-L-serine relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: part_of UPa:ULS00082 {cardinality="1", order="3"} ! L-serine from 3-phospho-D-glycerate [Term] id: UPa:UER00199 name: L-cysteine from L-serine: step 1/2 namespace: enzymatic_reaction def: "1 L-serine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-serine." [] xref: EC:2.3.1.30 xref: GO:0009001 "molecular_function:serine O-acetyltransferase activity" relationship: has_input_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="False"} ! acetyl-CoA relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00979 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-serine relationship: part_of UPa:ULS00083 {cardinality="1", order="1"} ! L-cysteine from L-serine [Term] id: UPa:UER00200 name: L-cysteine from L-serine: step 2/2 namespace: enzymatic_reaction def: "1 O-acetyl-L-serine + 1 hydrogen sulfide => 1 L-cysteine + 1 acetate." [] xref: EC:2.5.1.47 xref: GO:0004124 "molecular_function:cysteine synthase activity" relationship: has_input_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="False"} ! hydrogen sulfide relationship: has_input_compound UPa:UPC00979 {cardinality="1", is_alternate="False", is_primary="True"} ! O-acetyl-L-serine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: part_of UPa:ULS00083 {cardinality="1", order="2"} ! L-cysteine from L-serine [Term] id: UPa:UER00201 name: L-cysteine from L-homocysteine and L-serine: step 1/2 namespace: enzymatic_reaction def: "1 L-homocysteine + 1 L-serine => 1 H(2)O + 1 L-cystathionine." [] xref: EC:4.2.1.22 xref: GO:0004122 "molecular_function:cystathionine beta-synthase activity" relationship: has_input_compound UPa:UPC00065 {cardinality="1", is_alternate="False", is_primary="True"} ! L-serine relationship: has_input_compound UPa:UPC00155 {cardinality="1", is_alternate="False", is_primary="True"} ! L-homocysteine relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: part_of UPa:ULS00084 {cardinality="1", order="1"} ! L-cysteine from L-homocysteine and L-serine [Term] id: UPa:UER00202 name: L-cysteine from L-homocysteine and L-serine: step 2/2 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-cystathionine => 1 2-oxobutanoate + 1 L-cysteine + 1 NH(3)." [] xref: EC:4.4.1.1 xref: GO:0004123 "molecular_function:cystathionine gamma-lyase activity" xref: GO:0044540 "molecular_function:L-cystine L-cysteine-lyase (deaminating)" xref: GO:0080146 "molecular_function:L-cysteine desulfhydrase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC02291 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cystathionine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_output_compound UPa:UPC00109 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxobutanoate relationship: part_of UPa:ULS00084 {cardinality="1", order="2"} ! L-cysteine from L-homocysteine and L-serine [Term] id: UPa:UER00203 name: prephenate from chorismate: step 1/1 namespace: enzymatic_reaction def: "1 chorismate => 1 prephenate." [] xref: EC:5.4.99.5 xref: GO:0004106 "molecular_function:chorismate mutase activity" relationship: has_input_compound UPa:UPC00251 {cardinality="1", is_alternate="False", is_primary="True"} ! chorismate relationship: has_output_compound UPa:UPC00254 {cardinality="1", is_alternate="False", is_primary="True"} ! prephenate relationship: part_of UPa:ULS00085 {cardinality="1", order="1"} ! prephenate from chorismate [Term] id: UPa:UER00204 name: sulfite from sulfate: step 1/3 namespace: enzymatic_reaction def: "1 ATP + 1 sulfate => 1 5'-adenylyl sulfate + 1 diphosphate." [] xref: EC:2.7.7.4 xref: GO:0004781 "molecular_function:sulfate adenylyltransferase (ATP) activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00059 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00224 {cardinality="1", is_alternate="False", is_primary="True"} ! 5'-adenylyl sulfate relationship: part_of UPa:ULS00086 {cardinality="1", order="1"} ! sulfite from sulfate [Term] id: UPa:UER00205 name: sulfite from sulfate: step 2/3 namespace: enzymatic_reaction def: "1 5'-adenylyl sulfate + 1 ATP => 1 3'-phospho-5'-adenylyl sulfate + 1 ADP." [] xref: EC:2.7.1.25 xref: GO:0004020 "molecular_function:adenylylsulfate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00224 {cardinality="1", is_alternate="False", is_primary="True"} ! 5'-adenylyl sulfate relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00053 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-phospho-5'-adenylyl sulfate relationship: part_of UPa:ULS00086 {cardinality="1", order="2"} ! sulfite from sulfate [Term] id: UPa:UER00206 name: sulfite from sulfate: step 3/3 namespace: enzymatic_reaction def: "1 3'-phospho-5'-adenylyl sulfate + 1 thioredoxin => 1 adenosine 3',5'-bisphosphate + 1 sulfite + 1 thioredoxin disulfide." [] xref: EC:1.8.4.8 xref: GO:0004604 "molecular_function:phosphoadenylyl-sulfate reductase (thioredoxin) activity" relationship: has_input_compound UPa:UPC00053 {cardinality="1", is_alternate="False", is_primary="True"} ! 3'-phospho-5'-adenylyl sulfate relationship: has_input_compound UPa:UPC00342 {cardinality="1", is_alternate="False", is_primary="False"} ! thioredoxin relationship: has_output_compound UPa:UPC00054 {cardinality="1", is_alternate="False", is_primary="False"} ! adenosine 3',5'-bisphosphate relationship: has_output_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC00343 {cardinality="1", is_alternate="False", is_primary="False"} ! thioredoxin disulfide relationship: part_of UPa:ULS00086 {cardinality="1", order="3"} ! sulfite from sulfate [Term] id: UPa:UER00207 name: hydrogen sulfide from sulfite (NADPH route): step 1/1 namespace: enzymatic_reaction def: "3 H(+) + 3 NADPH + 1 sulfite => 3 H(2)O + 3 NADP(+) + 1 hydrogen sulfide." [] xref: EC:1.8.1.2 xref: GO:0004783 "molecular_function:sulfite reductase (NADPH) activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogen sulfide relationship: part_of UPa:ULS00087 {cardinality="1", order="1"} ! hydrogen sulfide from sulfite (NADPH route) [Term] id: UPa:UER00208 name: hydrogen sulfide from sulfite (ferredoxin route): step 1/1 namespace: enzymatic_reaction def: "6 H(+) + 6 reduced ferredoxin + 1 sulfite => 3 H(2)O + 1 hydrogen sulfide + 6 oxidized ferredoxin." [] xref: EC:1.8.7.1 xref: GO:0050311 "molecular_function:sulfite reductase (ferredoxin) activity" relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00094 {cardinality="1", is_alternate="False", is_primary="True"} ! sulfite relationship: has_input_compound UPa:UPC00138 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced ferredoxin relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00139 {cardinality="1", is_alternate="False", is_primary="False"} ! oxidized ferredoxin relationship: has_output_compound UPa:UPC00283 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogen sulfide relationship: part_of UPa:ULS00088 {cardinality="1", order="1"} ! hydrogen sulfide from sulfite (ferredoxin route) [Term] id: UPa:UER00209 name: glutathione from L-cysteine and L-glutamate: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-cysteine + 1 L-glutamate => 1 ADP + 1 L-gamma-glutamyl-L-cysteine + 1 phosphate." [] xref: EC:6.3.2.2 xref: GO:0004357 "molecular_function:glutamate-cysteine ligase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00669 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gamma-glutamyl-L-cysteine relationship: part_of UPa:ULS00089 {cardinality="1", order="1"} ! glutathione from L-cysteine and L-glutamate [Term] id: UPa:UER00210 name: glutathione from L-cysteine and L-glutamate: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 L-gamma-glutamyl-L-cysteine + 1 glycine => 1 ADP + 1 glutathione + 1 phosphate." [] xref: EC:6.3.2.3 xref: GO:0004363 "molecular_function:glutathione synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00037 {cardinality="1", is_alternate="False", is_primary="False"} ! glycine relationship: has_input_compound UPa:UPC00669 {cardinality="1", is_alternate="False", is_primary="True"} ! L-gamma-glutamyl-L-cysteine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00051 {cardinality="1", is_alternate="False", is_primary="True"} ! glutathione relationship: part_of UPa:ULS00089 {cardinality="1", order="2"} ! glutathione from L-cysteine and L-glutamate [Term] id: UPa:UER00211 name: precorrin-2 from uroporphyrinogen III: step 1/1 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 uroporphyrinogen III => 2 S-adenosyl-L-homocysteine + 1 precorrin-2." [] xref: EC:2.1.1.107 xref: GO:0004851 "molecular_function:uroporphyrin-III C-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC01051 {cardinality="1", is_alternate="False", is_primary="True"} ! uroporphyrinogen III relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: part_of UPa:ULS00090 {cardinality="1", order="1"} ! precorrin-2 from uroporphyrinogen III [Term] id: UPa:UER00212 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-2 => 1 H(+) + 1 S-adenosyl-L-homocysteine + 1 precorrin-3A." [] xref: EC:2.1.1.130 xref: GO:0030788 "molecular_function:precorrin-2 C20-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05772 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3A relationship: part_of UPa:ULS00091 {cardinality="1", order="1"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00213 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 precorrin-3A => 1 H(2)O + 1 NAD(+) + 1 precorrin-3B." [] xref: EC:1.14.13.83 xref: GO:0043818 "molecular_function:precorrin-3B synthase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC05772 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3A relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC06406 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3B relationship: part_of UPa:ULS00091 {cardinality="1", order="2"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00214 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-3B => 1 S-adenosyl-L-homocysteine + 1 precorrin-4." [] xref: EC:2.1.1.131 xref: GO:0030789 "molecular_function:precorrin-3B C17-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06406 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-3B relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06407 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-4 relationship: part_of UPa:ULS00091 {cardinality="1", order="3"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00215 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 4/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 precorrin-4 => 1 S-adenosyl-L-homocysteine + 1 precorrin-5." [] xref: EC:2.1.1.133 xref: GO:0046026 "molecular_function:precorrin-4 C11-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06407 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-4 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06416 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-5 relationship: part_of UPa:ULS00091 {cardinality="1", order="4"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00216 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10 namespace: enzymatic_reaction def: "1 H(2)O + 1 S-adenosyl-L-methionine + 1 precorrin-5 => 1 S-adenosyl-L-homocysteine + 1 acetate + 1 precorrin-6A." [] xref: EC:2.1.1.152 xref: GO:0043819 "molecular_function:precorrin-6A synthase (deacetylating) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06416 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-5 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC00033 {cardinality="1", is_alternate="False", is_primary="False"} ! acetate relationship: has_output_compound UPa:UPC06320 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6A relationship: part_of UPa:ULS00091 {cardinality="1", order="5"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00217 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 precorrin-6A => 1 NADP(+) + 1 precorrin-6B." [] xref: EC:1.3.1.54 xref: GO:0016994 "molecular_function:precorrin-6A reductase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06320 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6A relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC06319 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6B relationship: part_of UPa:ULS00091 {cardinality="1", order="6"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00218 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 precorrin-8X." [] xref: EC:2.1.1.132 xref: GO:0046025 "molecular_function:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC06319 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC06408 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-8X relationship: part_of UPa:ULS00091 {cardinality="1", order="7"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00219 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10 namespace: enzymatic_reaction def: "1 precorrin-8X => 1 hydrogenobyrinic acid." [] xref: EC:5.4.99.61 xref: GO:0016993 "molecular_function:precorrin-8X methylmutase activity" relationship: has_input_compound UPa:UPC06408 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-8X relationship: has_output_compound UPa:UPC06399 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid relationship: part_of UPa:ULS00091 {cardinality="1", order="8"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00220 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10 namespace: enzymatic_reaction def: "2 ATP + 2 H(2)O + 2 L-glutamine + 1 hydrogenobyrinic acid => 2 ADP + 2 L-glutamate + 1 hydrogenobyrinic acid a,c-diamide + 2 phosphate." [] xref: EC:6.3.5.9 xref: GO:0043802 "molecular_function:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC06399 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC06503 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid a,c-diamide relationship: part_of UPa:ULS00091 {cardinality="1", order="9"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00221 name: cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 10/10 namespace: enzymatic_reaction def: "1 ATP + 1 Co(2+) + 1 H(2)O + 1 hydrogenobyrinic acid a,c-diamide => 1 ADP + 1 H(+) + 1 cob(II)yrinate a,c-diamide + 1 phosphate." [] xref: EC:6.6.1.2 xref: GO:0051116 "molecular_function:cobaltochelatase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00175 {cardinality="1", is_alternate="False", is_primary="False"} ! Co(2+) relationship: has_input_compound UPa:UPC06503 {cardinality="1", is_alternate="False", is_primary="True"} ! hydrogenobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00091 {cardinality="1", order="10"} ! cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route) [Term] id: UPa:UER00222 name: sirohydrochlorin from precorrin-2: step 1/1 namespace: enzymatic_reaction def: "1 NAD(+) + 1 precorrin-2 => 1 H(+) + 1 NADH + 1 sirohydrochlorin." [] xref: EC:1.3.1.76 xref: GO:0043115 "molecular_function:precorrin-2 dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC02463 {cardinality="1", is_alternate="False", is_primary="True"} ! precorrin-2 relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05778 {cardinality="1", is_alternate="False", is_primary="True"} ! sirohydrochlorin relationship: part_of UPa:ULS00173 {cardinality="1", order="1"} ! sirohydrochlorin from precorrin-2 [Term] id: UPa:UER00223 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 1/10 namespace: enzymatic_reaction def: "1 Co(2+) + 1 sirohydrochlorin => 2 H(+) + 1 cobalt-precorrin-2." [] xref: EC:4.99.1.3 xref: GO:0016852 "molecular_function:sirohydrochlorin cobaltochelatase activity" relationship: has_input_compound UPa:UPC00175 {cardinality="1", is_alternate="False", is_primary="False"} ! Co(2+) relationship: has_input_compound UPa:UPC05778 {cardinality="1", is_alternate="False", is_primary="True"} ! sirohydrochlorin relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC11538 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-2 relationship: part_of UPa:ULS00092 {cardinality="1", order="1"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00224 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 2/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin-2 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 3." [] xref: EC:2.1.1.151 xref: GO:0043781 "molecular_function:cobalt-factor II C20-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11538 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-2 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11539 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 3 relationship: part_of UPa:ULS00092 {cardinality="1", order="2"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00225 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 3/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 3 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 4." [] xref: EC:2.1.1 xref: GO:0000179 "molecular_function:rRNA (adenine-N6,N6-)-dimethyltransferase activity" xref: GO:0003880 "molecular_function:protein C-terminal carboxyl O-methyltransferase activity" xref: GO:0004809 "molecular_function:tRNA (guanine-N2-)-methyltransferase activity" xref: GO:0008168 "molecular_function:methyltransferase activity" xref: GO:0008169 "molecular_function:C-methyltransferase activity" xref: GO:0008170 "molecular_function:N-methyltransferase activity" xref: GO:0008171 "molecular_function:O-methyltransferase activity" xref: GO:0008172 "molecular_function:S-methyltransferase activity" xref: GO:0008173 "molecular_function:RNA methyltransferase activity" xref: GO:0008174 "molecular_function:mRNA methyltransferase activity" xref: GO:0008175 "molecular_function:tRNA methyltransferase activity" xref: GO:0008276 "molecular_function:protein methyltransferase activity" xref: GO:0008425 "molecular_function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" xref: GO:0008649 "molecular_function:rRNA methyltransferase activity" xref: GO:0008650 "molecular_function:rRNA (uridine-2'-O-)-methyltransferase activity" xref: GO:0008988 "molecular_function:rRNA (adenine-N6-)-methyltransferase activity" xref: GO:0009008 "molecular_function:DNA-methyltransferase activity" xref: GO:0009019 "molecular_function:tRNA (guanine-N1-)-methyltransferase activity" xref: GO:0009383 "molecular_function:rRNA (cytosine-C5-)-methyltransferase activity" xref: GO:0016205 "molecular_function:selenocysteine methyltransferase activity" xref: GO:0016273 "molecular_function:arginine N-methyltransferase activity" xref: GO:0016274 "molecular_function:protein-arginine N-methyltransferase activity" xref: GO:0016278 "molecular_function:lysine N-methyltransferase activity" xref: GO:0016279 "molecular_function:protein-lysine N-methyltransferase activity" xref: GO:0016300 "molecular_function:tRNA (uracil) methyltransferase activity" xref: GO:0016423 "molecular_function:tRNA (guanine) methyltransferase activity" xref: GO:0016426 "molecular_function:tRNA (adenine) methyltransferase activity" xref: GO:0016427 "molecular_function:tRNA (cytosine) methyltransferase activity" xref: GO:0016428 "molecular_function:tRNA (cytosine-5-)-methyltransferase activity" xref: GO:0016429 "molecular_function:tRNA (adenine-N1-)-methyltransferase activity" xref: GO:0016433 "molecular_function:rRNA (adenine) methyltransferase activity" xref: GO:0016434 "molecular_function:rRNA (cytosine) methyltransferase activity" xref: GO:0016435 "molecular_function:rRNA (guanine) methyltransferase activity" xref: GO:0016436 "molecular_function:rRNA (uridine) methyltransferase activity" xref: GO:0018423 "molecular_function:protein C-terminal leucine carboxyl O-methyltransferase activity" xref: GO:0018707 "molecular_function:1-phenanthrol methyltransferase activity" xref: GO:0019702 "molecular_function:protein-arginine N5-methyltransferase activity" xref: GO:0030792 "molecular_function:methylarsonite methyltransferase activity" xref: GO:0034541 "molecular_function:dimethylarsinite methyltransferase activity" xref: GO:0034807 "molecular_function:4,5-dihydroxybenzo(a)pyrene methyltransferase activity" xref: GO:0034931 "molecular_function:1-hydroxypyrene methyltransferase activity" xref: GO:0034933 "molecular_function:1-hydroxy-6-methoxypyrene methyltransferase activity" xref: GO:0043770 "molecular_function:demethylmenaquinone methyltransferase activity" xref: GO:0043776 "molecular_function:cobalt-precorrin-6B C5-methyltransferase activity" xref: GO:0043777 "molecular_function:cobalt-precorrin-7 C15-methyltransferase activity" xref: GO:0043780 "molecular_function:cobalt-precorrin-5B C1-methyltransferase activity" xref: GO:0043782 "molecular_function:cobalt-precorrin-3 C17-methyltransferase activity" xref: GO:0043791 "molecular_function:dimethylamine methyltransferase activity" xref: GO:0043803 "molecular_function:hydroxyneurosporene-O-methyltransferase activity" xref: GO:0043827 "molecular_function:tRNA (adenine-57, 58-N(1)-) methyltransferase activity" xref: GO:0043833 "molecular_function:methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043834 "molecular_function:trimethylamine methyltransferase activity" xref: GO:0043851 "molecular_function:methanol-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043852 "molecular_function:monomethylamine methyltransferase activity" xref: GO:0051994 "molecular_function:P-methyltransferase activity" xref: GO:0051995 "molecular_function:Se-methyltransferase activity" xref: GO:0052624 "molecular_function:2-phytyl-1,4-naphthoquinone methyltransferase activity" xref: GO:0052665 "molecular_function:tRNA (uracil-2'-O-)-methyltransferase activity" xref: GO:0052666 "molecular_function:tRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0052667 "molecular_function:phosphomethylethanolamine N-methyltransferase activity" xref: GO:0052735 "molecular_function:tRNA (cytosine-3-)-methyltransferase activity" xref: GO:0070677 "molecular_function:rRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0071424 "molecular_function:rRNA (cytosine-N4-)-methyltransferase activity" xref: GO:0080012 "molecular_function:trihydroxyferuloyl spermidine O-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11539 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 3 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11540 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 4 relationship: part_of UPa:ULS00092 {cardinality="1", order="3"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00226 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 4/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 4 => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 5A." [] xref: EC:2.1.1.271 relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11540 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 4 relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC16242 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5A relationship: part_of UPa:ULS00092 {cardinality="1", order="4"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00227 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10 namespace: enzymatic_reaction def: "1 S-adenosyl-L-methionine + 1 cobalt-precorrin 5B => 1 S-adenosyl-L-homocysteine + 1 cobalt-precorrin-6A." [] xref: EC:2.1.1.195 relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC16243 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 5B relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11542 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6A relationship: part_of UPa:ULS00092 {cardinality="1", order="6"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00228 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 7/10 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 cobalt-precorrin-6A => 1 NAD(+) + 1 cobalt-precorrin-6B." [] xref: EC:1.3.1.106 relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC11542 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6A relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC11543 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6B relationship: part_of UPa:ULS00092 {cardinality="1", order="7"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00229 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10 namespace: enzymatic_reaction def: "2 S-adenosyl-L-methionine + 1 cobalt-precorrin-6B => 1 CO(2) + 2 S-adenosyl-L-homocysteine + 1 cobalt-precorrin 8." [] xref: EC:2.1.1 xref: GO:0000179 "molecular_function:rRNA (adenine-N6,N6-)-dimethyltransferase activity" xref: GO:0003880 "molecular_function:protein C-terminal carboxyl O-methyltransferase activity" xref: GO:0004809 "molecular_function:tRNA (guanine-N2-)-methyltransferase activity" xref: GO:0008168 "molecular_function:methyltransferase activity" xref: GO:0008169 "molecular_function:C-methyltransferase activity" xref: GO:0008170 "molecular_function:N-methyltransferase activity" xref: GO:0008171 "molecular_function:O-methyltransferase activity" xref: GO:0008172 "molecular_function:S-methyltransferase activity" xref: GO:0008173 "molecular_function:RNA methyltransferase activity" xref: GO:0008174 "molecular_function:mRNA methyltransferase activity" xref: GO:0008175 "molecular_function:tRNA methyltransferase activity" xref: GO:0008276 "molecular_function:protein methyltransferase activity" xref: GO:0008425 "molecular_function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" xref: GO:0008649 "molecular_function:rRNA methyltransferase activity" xref: GO:0008650 "molecular_function:rRNA (uridine-2'-O-)-methyltransferase activity" xref: GO:0008988 "molecular_function:rRNA (adenine-N6-)-methyltransferase activity" xref: GO:0009008 "molecular_function:DNA-methyltransferase activity" xref: GO:0009019 "molecular_function:tRNA (guanine-N1-)-methyltransferase activity" xref: GO:0009383 "molecular_function:rRNA (cytosine-C5-)-methyltransferase activity" xref: GO:0016205 "molecular_function:selenocysteine methyltransferase activity" xref: GO:0016273 "molecular_function:arginine N-methyltransferase activity" xref: GO:0016274 "molecular_function:protein-arginine N-methyltransferase activity" xref: GO:0016278 "molecular_function:lysine N-methyltransferase activity" xref: GO:0016279 "molecular_function:protein-lysine N-methyltransferase activity" xref: GO:0016300 "molecular_function:tRNA (uracil) methyltransferase activity" xref: GO:0016423 "molecular_function:tRNA (guanine) methyltransferase activity" xref: GO:0016426 "molecular_function:tRNA (adenine) methyltransferase activity" xref: GO:0016427 "molecular_function:tRNA (cytosine) methyltransferase activity" xref: GO:0016428 "molecular_function:tRNA (cytosine-5-)-methyltransferase activity" xref: GO:0016429 "molecular_function:tRNA (adenine-N1-)-methyltransferase activity" xref: GO:0016433 "molecular_function:rRNA (adenine) methyltransferase activity" xref: GO:0016434 "molecular_function:rRNA (cytosine) methyltransferase activity" xref: GO:0016435 "molecular_function:rRNA (guanine) methyltransferase activity" xref: GO:0016436 "molecular_function:rRNA (uridine) methyltransferase activity" xref: GO:0018423 "molecular_function:protein C-terminal leucine carboxyl O-methyltransferase activity" xref: GO:0018707 "molecular_function:1-phenanthrol methyltransferase activity" xref: GO:0019702 "molecular_function:protein-arginine N5-methyltransferase activity" xref: GO:0030792 "molecular_function:methylarsonite methyltransferase activity" xref: GO:0034541 "molecular_function:dimethylarsinite methyltransferase activity" xref: GO:0034807 "molecular_function:4,5-dihydroxybenzo(a)pyrene methyltransferase activity" xref: GO:0034931 "molecular_function:1-hydroxypyrene methyltransferase activity" xref: GO:0034933 "molecular_function:1-hydroxy-6-methoxypyrene methyltransferase activity" xref: GO:0043770 "molecular_function:demethylmenaquinone methyltransferase activity" xref: GO:0043776 "molecular_function:cobalt-precorrin-6B C5-methyltransferase activity" xref: GO:0043777 "molecular_function:cobalt-precorrin-7 C15-methyltransferase activity" xref: GO:0043780 "molecular_function:cobalt-precorrin-5B C1-methyltransferase activity" xref: GO:0043782 "molecular_function:cobalt-precorrin-3 C17-methyltransferase activity" xref: GO:0043791 "molecular_function:dimethylamine methyltransferase activity" xref: GO:0043803 "molecular_function:hydroxyneurosporene-O-methyltransferase activity" xref: GO:0043827 "molecular_function:tRNA (adenine-57, 58-N(1)-) methyltransferase activity" xref: GO:0043833 "molecular_function:methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043834 "molecular_function:trimethylamine methyltransferase activity" xref: GO:0043851 "molecular_function:methanol-specific methylcobalamin:coenzyme M methyltransferase activity" xref: GO:0043852 "molecular_function:monomethylamine methyltransferase activity" xref: GO:0051994 "molecular_function:P-methyltransferase activity" xref: GO:0051995 "molecular_function:Se-methyltransferase activity" xref: GO:0052624 "molecular_function:2-phytyl-1,4-naphthoquinone methyltransferase activity" xref: GO:0052665 "molecular_function:tRNA (uracil-2'-O-)-methyltransferase activity" xref: GO:0052666 "molecular_function:tRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0052667 "molecular_function:phosphomethylethanolamine N-methyltransferase activity" xref: GO:0052735 "molecular_function:tRNA (cytosine-3-)-methyltransferase activity" xref: GO:0070677 "molecular_function:rRNA (cytosine-2'-O-)-methyltransferase activity" xref: GO:0071424 "molecular_function:rRNA (cytosine-N4-)-methyltransferase activity" xref: GO:0080012 "molecular_function:trihydroxyferuloyl spermidine O-methyltransferase activity" relationship: has_input_compound UPa:UPC00019 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-methionine relationship: has_input_compound UPa:UPC11543 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin-6B relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00021 {cardinality="1", is_alternate="False", is_primary="False"} ! S-adenosyl-L-homocysteine relationship: has_output_compound UPa:UPC11545 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 8 relationship: part_of UPa:ULS00092 {cardinality="1", order="8"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00230 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10 namespace: enzymatic_reaction def: "1 cobalt-precorrin 8 => 1 cob(III)yrinic acid." [] xref: EC:5.4.1 xref: GO:0016867 "molecular_function:intramolecular transferase activity, transferring acyl groups" xref: GO:0043778 "molecular_function:cobalt-precorrin-8 methylmutase activity" relationship: has_input_compound UPa:UPC11545 {cardinality="1", is_alternate="False", is_primary="True"} ! cobalt-precorrin 8 relationship: has_output_compound UPa:UPC05773 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(III)yrinic acid relationship: part_of UPa:ULS00092 {cardinality="1", order="9"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00231 name: cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10 namespace: enzymatic_reaction def: "2 ATP + 2 H(2)O + 2 L-glutamine + 1 cob(III)yrinic acid => 2 ADP + 2 L-glutamate + 1 cob(II)yrinate a,c-diamide + 2 phosphate." [] xref: EC:6.3.1 xref: GO:0016211 "molecular_function:ammonia ligase activity" xref: GO:0016880 "molecular_function:acid-ammonia (or amide) ligase activity" xref: GO:0043860 "molecular_function:cyanophycin synthetase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC05773 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(III)yrinic acid relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: part_of UPa:ULS00092 {cardinality="1", order="10"} ! cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route) [Term] id: UPa:UER00232 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 1/7 namespace: enzymatic_reaction def: "1 FMNH(2) + 2 cob(II)yrinate a,c-diamide => 1 FMN + 2 H(+) + 2 cob(I)yrinic acid a,c-diamide." [] xref: EC:1.16.8.1 xref: GO:0043784 "molecular_function:cob(II)yrinic acid a,c-diamide reductase activity" relationship: has_input_compound UPa:UPC01847 {cardinality="1", is_alternate="False", is_primary="False"} ! FMNH(2) relationship: has_input_compound UPa:UPC06504 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(II)yrinate a,c-diamide relationship: has_output_compound UPa:UPC00061 {cardinality="1", is_alternate="False", is_primary="False"} ! FMN relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC06505 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(I)yrinic acid a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="1"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00233 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7 namespace: enzymatic_reaction def: "1 ATP + 1 cob(I)yrinic acid a,c-diamide => 1 adenosylcob(III)yrinic acid a,c-diamide + 1 triphosphate." [] xref: EC:2.5.1.17 xref: GO:0008817 "molecular_function:cob(I)yrinic acid a,c-diamide adenosyltransferase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC06505 {cardinality="1", is_alternate="False", is_primary="True"} ! cob(I)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00536 {cardinality="1", is_alternate="False", is_primary="False"} ! triphosphate relationship: has_output_compound UPa:UPC06506 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="2"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00234 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 3/7 namespace: enzymatic_reaction def: "4 ATP + 4 H(2)O + 4 L-glutamine + 1 adenosylcob(III)yrinic acid a,c-diamide => 4 ADP + 4 L-glutamate + 1 adenosylcobyrinic acid a,c-diamide + 4 phosphate." [] xref: EC:6.3.5.10 xref: GO:0051921 "molecular_function:adenosylcobyric acid synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC06506 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcob(III)yrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC06507 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobyrinic acid a,c-diamide relationship: part_of UPa:ULS00093 {cardinality="1", order="3"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00235 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 4/7 namespace: enzymatic_reaction def: "1 (R)-1-aminopropan-2-ol + 1 adenosylcobyrinic acid a,c-diamide => 1 H(2)O + 1 adenosylcobinamide." [] xref: EC:6.3.1.10 xref: GO:0043757 "molecular_function:adenosylcobinamide-phosphate synthase activity" relationship: has_input_compound UPa:UPC03194 {cardinality="1", is_alternate="False", is_primary="False"} ! (R)-1-aminopropan-2-ol relationship: has_input_compound UPa:UPC06507 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobyrinic acid a,c-diamide relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: part_of UPa:ULS00093 {cardinality="1", order="4"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00236 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7 namespace: enzymatic_reaction def: "adenosylcobinamide + [ATP or GTP] => adenosylcobinamide phosphate + [ADP or GDP]." [] xref: EC:2.7.1.156 xref: GO:0043752 "molecular_function:adenosylcobinamide kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="True", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="True", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC06508 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="True", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00035 {cardinality="1", is_alternate="True", is_primary="False"} ! GDP relationship: has_output_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: part_of UPa:ULS00093 {cardinality="1", order="5"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00237 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7 namespace: enzymatic_reaction def: "1 GTP + 1 adenosylcobinamide phosphate => 1 adenosylcobinamide-GDP + 1 diphosphate." [] xref: EC:2.7.7.62 xref: GO:0008820 "molecular_function:cobinamide phosphate guanylyltransferase activity" relationship: has_input_compound UPa:UPC00044 {cardinality="1", is_alternate="False", is_primary="False"} ! GTP relationship: has_input_compound UPa:UPC06509 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide phosphate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC06510 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide-GDP relationship: part_of UPa:ULS00093 {cardinality="1", order="6"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00238 name: adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7 namespace: enzymatic_reaction def: "1 adenosylcobinamide-GDP + 1 alpha-ribazole => 1 GMP + 1 adenosylcobalamin." [] xref: EC:2.7.8.26 xref: GO:0051073 "molecular_function:adenosylcobinamide-GDP ribazoletransferase activity" relationship: has_input_compound UPa:UPC05775 {cardinality="1", is_alternate="False", is_primary="False"} ! alpha-ribazole relationship: has_input_compound UPa:UPC06510 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobinamide-GDP relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="False"} ! GMP relationship: has_output_compound UPa:UPC00194 {cardinality="1", is_alternate="False", is_primary="True"} ! adenosylcobalamin relationship: part_of UPa:ULS00093 {cardinality="1", order="7"} ! adenosylcobalamin from cob(II)yrinate a,c-diamide [Term] id: UPa:UER00239 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3 namespace: enzymatic_reaction def: "3 ATP + 1 H(2)O + 1 L-alpha-aminoadipate + 1 L-cysteine + 1 L-valine => 3 AMP + 1 N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 diphosphate." [] xref: EC:6.3.2.26 xref: GO:0050564 "molecular_function:N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00097 {cardinality="1", is_alternate="False", is_primary="True"} ! L-cysteine relationship: has_input_compound UPa:UPC00183 {cardinality="1", is_alternate="False", is_primary="True"} ! L-valine relationship: has_input_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="True"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC05556 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: part_of UPa:ULS00094 {cardinality="1", order="1"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00240 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3 namespace: enzymatic_reaction def: "1 N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 1 O(2) => 2 H(2)O + 1 isopenicillin N." [] xref: EC:1.21.3.1 xref: GO:0016216 "molecular_function:isopenicillin-N synthase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC05556 {cardinality="1", is_alternate="False", is_primary="True"} ! N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC05557 {cardinality="1", is_alternate="False", is_primary="True"} ! isopenicillin N relationship: part_of UPa:ULS00094 {cardinality="1", order="2"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00241 name: penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 3/3 namespace: enzymatic_reaction def: "1 H(2)O + 1 isopenicillin N + 1 phenylacetyl-CoA => 1 CoA + 1 L-alpha-aminoadipate + 1 penicillin G." [] xref: EC:2.3.1.164 xref: GO:0050640 "molecular_function:isopenicillin-N N-acyltransferase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00582 {cardinality="1", is_alternate="False", is_primary="False"} ! phenylacetyl-CoA relationship: has_input_compound UPa:UPC05557 {cardinality="1", is_alternate="False", is_primary="True"} ! isopenicillin N relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC00956 {cardinality="1", is_alternate="False", is_primary="False"} ! L-alpha-aminoadipate relationship: has_output_compound UPa:UPC05551 {cardinality="1", is_alternate="False", is_primary="True"} ! penicillin G relationship: part_of UPa:ULS00094 {cardinality="1", order="3"} ! penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine [Term] id: UPa:UER00242 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 1/8 namespace: enzymatic_reaction def: "1 D-glyceraldehyde 3-phosphate + 1 L-arginine => 1 N(2)-(2-carboxyethyl)-L-arginine + 1 phosphate." [] xref: EC:2.5.1.66 xref: GO:0033848 "molecular_function:N2-(2-carboxyethyl)arginine synthase activity" relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_input_compound UPa:UPC00118 {cardinality="1", is_alternate="False", is_primary="True"} ! D-glyceraldehyde 3-phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC06655 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: part_of UPa:ULS00095 {cardinality="1", order="1"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00243 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 2/8 namespace: enzymatic_reaction def: "1 ATP + 1 N(2)-(2-carboxyethyl)-L-arginine => 1 AMP + 1 deoxyamidinoproclavaminic acid + 1 diphosphate." [] xref: EC:6.3.3.4 xref: GO:0034027 "molecular_function:(carboxyethyl)arginine beta-lactam-synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC06655 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-(2-carboxyethyl)-L-arginine relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC06656 {cardinality="1", is_alternate="False", is_primary="True"} ! deoxyamidinoproclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="2"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00244 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 3/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 deoxyamidinoproclavaminic acid => 1 CO(2) + 1 amidinoproclavaminic acid + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06656 {cardinality="1", is_alternate="False", is_primary="True"} ! deoxyamidinoproclavaminic acid relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06657 {cardinality="1", is_alternate="False", is_primary="True"} ! amidinoproclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="3"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00245 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8 namespace: enzymatic_reaction def: "1 H(2)O + 1 amidinoproclavaminic acid => 1 proclavaminic acid + 1 urea." [] xref: EC:3.5.3.22 xref: GO:0033972 "molecular_function:proclavaminate amidinohydrolase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC06657 {cardinality="1", is_alternate="False", is_primary="True"} ! amidinoproclavaminic acid relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="False"} ! urea relationship: has_output_compound UPa:UPC06658 {cardinality="1", is_alternate="False", is_primary="True"} ! proclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="4"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00246 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 5/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 proclavaminic acid => 1 CO(2) + 1 H(2)O + 1 dihydroclavaminic acid + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06658 {cardinality="1", is_alternate="False", is_primary="True"} ! proclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06659 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydroclavaminic acid relationship: part_of UPa:ULS00095 {cardinality="1", order="5"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00247 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 6/8 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 O(2) + 1 dihydroclavaminic acid => 1 CO(2) + 1 H(2)O + 1 clavaminate + 1 succinate." [] xref: EC:1.14.11.21 xref: GO:0033758 "molecular_function:clavaminate synthase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC06659 {cardinality="1", is_alternate="False", is_primary="True"} ! dihydroclavaminic acid relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC06660 {cardinality="1", is_alternate="False", is_primary="True"} ! clavaminate relationship: part_of UPa:ULS00095 {cardinality="1", order="6"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00248 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 7/8 namespace: enzymatic_reaction def: "1 clavaminate => 1 clavulanate-9-aldehyde." [] relationship: has_input_compound UPa:UPC06660 {cardinality="1", is_alternate="False", is_primary="True"} ! clavaminate relationship: has_output_compound UPa:UPC06661 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate-9-aldehyde relationship: part_of UPa:ULS00095 {cardinality="1", order="7"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00249 name: clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 8/8 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 clavulanate-9-aldehyde => 1 NADP(+) + 1 clavulanate." [] relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06661 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate-9-aldehyde relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC06662 {cardinality="1", is_alternate="False", is_primary="True"} ! clavulanate relationship: part_of UPa:ULS00095 {cardinality="1", order="8"} ! clavulanate from D-glyceraldehyde 3-phosphate and L-arginine [Term] id: UPa:UER00250 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 biphenyl => 1 NAD(+) + 1 cis-3-phenylcyclohexa-3,5-diene-1,2-diol." [] xref: EC:1.14.12.18 xref: GO:0018687 "molecular_function:biphenyl 2,3-dioxygenase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC06588 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC06589 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: part_of UPa:ULS00096 {cardinality="1", order="1"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00251 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 2/4 namespace: enzymatic_reaction def: "1 NAD(+) + 1 cis-3-phenylcyclohexa-3,5-diene-1,2-diol => 1 H(+) + 1 NADH + 1 biphenyl-2,3-diol." [] xref: EC:1.3.1.56 xref: GO:0018509 "molecular_function:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06589 {cardinality="1", is_alternate="False", is_primary="True"} ! cis-3-phenylcyclohexa-3,5-diene-1,2-diol relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC02526 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,3-diol relationship: part_of UPa:ULS00096 {cardinality="1", order="2"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00252 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 3/4 namespace: enzymatic_reaction def: "1 O(2) + 1 biphenyl-2,3-diol => 1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate." [] xref: EC:1.13.11.39 xref: GO:0018583 "molecular_function:biphenyl-2,3-diol 1,2-dioxygenase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC02526 {cardinality="1", is_alternate="False", is_primary="True"} ! biphenyl-2,3-diol relationship: has_output_compound UPa:UPC01273 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: part_of UPa:ULS00096 {cardinality="1", order="3"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00253 name: 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4 namespace: enzymatic_reaction def: "1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + 1 H(2)O => 1 2-hydroxy-2,4-pentadienoate + 1 benzoate." [] xref: EC:3.7.1.8 xref: GO:0018774 "molecular_function:2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC01273 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate relationship: has_output_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_output_compound UPa:UPC00596 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-hydroxy-2,4-pentadienoate relationship: part_of UPa:ULS00096 {cardinality="1", order="4"} ! 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl [Term] id: UPa:UER00254 name: catechol from benzoate: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADH + 1 O(2) + 1 benzoate => 1 (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + 1 NAD(+)." [] xref: EC:1.14.12.10 xref: GO:0018623 "molecular_function:benzoate 1,2-dioxygenase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC06321 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: part_of UPa:ULS00097 {cardinality="1", order="1"} ! catechol from benzoate [Term] id: UPa:UER00255 name: catechol from benzoate: step 2/2 namespace: enzymatic_reaction def: "1 (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid + 1 NAD(+) => 1 CO(2) + 1 H(+) + 1 NADH + 1 catechol." [] xref: EC:1.3.1.25 xref: GO:0047116 "molecular_function:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity" relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC06321 {cardinality="1", is_alternate="False", is_primary="True"} ! (1R,6S)-1,6-dihydroxycyclohexa-2,4-dienecarboxylic acid relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: part_of UPa:ULS00097 {cardinality="1", order="2"} ! catechol from benzoate [Term] id: UPa:UER00256 name: 3,4-dihydroxybenzoate from benzoate: step 1/2 namespace: enzymatic_reaction def: "1 H(+) + 1 NADPH + 1 O(2) + 1 benzoate => 1 4-hydroxybenzoate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.12 xref: GO:0018664 "molecular_function:benzoate 4-monooxygenase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00180 {cardinality="1", is_alternate="False", is_primary="True"} ! benzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoate relationship: part_of UPa:ULS00098 {cardinality="1", order="1"} ! 3,4-dihydroxybenzoate from benzoate [Term] id: UPa:UER00257 name: 3,4-dihydroxybenzoate from benzoate: step 2/2 namespace: enzymatic_reaction def: "1 4-hydroxybenzoate + 1 H(+) + 1 NADPH + 1 O(2) => 1 3,4-dihydroxybenzoate + 1 H(2)O + 1 NADP(+)." [] xref: EC:1.14.13.2 xref: GO:0018659 "molecular_function:4-hydroxybenzoate 3-monooxygenase activity" relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="False", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00156 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-hydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="False", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: part_of UPa:ULS00098 {cardinality="1", order="2"} ! 3,4-dihydroxybenzoate from benzoate [Term] id: UPa:UER00258 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3 namespace: enzymatic_reaction def: "1 O(2) + 1 catechol => 1 cis,cis-muconate." [] xref: EC:1.13.11.1 xref: GO:0018576 "molecular_function:catechol 1,2-dioxygenase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00090 {cardinality="1", is_alternate="False", is_primary="True"} ! catechol relationship: has_output_compound UPa:UPC02480 {cardinality="1", is_alternate="False", is_primary="True"} ! cis,cis-muconate relationship: part_of UPa:ULS00099 {cardinality="1", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00259 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3 namespace: enzymatic_reaction def: "1 cis,cis-muconate => 1 (S)-5-oxo-2,5-dihydro-2-furylacetic acid." [] xref: EC:5.5.1.1 xref: GO:0018849 "molecular_function:muconate cycloisomerase activity" relationship: has_input_compound UPa:UPC02480 {cardinality="1", is_alternate="False", is_primary="True"} ! cis,cis-muconate relationship: has_output_compound UPa:UPC14610 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: part_of UPa:ULS00099 {cardinality="1", order="2"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00260 name: 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 3/3 namespace: enzymatic_reaction def: "1 (S)-5-oxo-2,5-dihydro-2-furylacetic acid => 1 5-oxo-4,5-dihydro-2-furylacetate." [] xref: EC:5.3.3.4 xref: GO:0016159 "molecular_function:muconolactone delta-isomerase activity" relationship: has_input_compound UPa:UPC14610 {cardinality="1", is_alternate="False", is_primary="True"} ! (S)-5-oxo-2,5-dihydro-2-furylacetic acid relationship: has_output_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:ULS00099 {cardinality="1", order="3"} ! 5-oxo-4,5-dihydro-2-furylacetate from catechol [Term] id: UPa:UER00261 name: 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate: step 1/1 namespace: enzymatic_reaction def: "1 5-oxo-4,5-dihydro-2-furylacetate + 1 H(2)O => 1 3-oxoadipate." [] xref: EC:3.1.1.24 xref: GO:0047570 "molecular_function:3-oxoadipate enol-lactonase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: part_of UPa:ULS00100 {cardinality="1", order="1"} ! 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate [Term] id: UPa:UER00262 name: acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 1/2 namespace: enzymatic_reaction def: "1 3-oxoadipate + 1 succinyl-CoA => 1 3-oxoadipyl-CoA + 1 succinate." [] xref: EC:2.8.3.6 xref: GO:0047569 "molecular_function:3-oxoadipate CoA-transferase activity" relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_input_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="False"} ! succinate relationship: has_output_compound UPa:UPC02232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipyl-CoA relationship: part_of UPa:ULS00101 {cardinality="1", order="1"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate [Term] id: UPa:UER00263 name: acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 namespace: enzymatic_reaction def: "1 3-oxoadipyl-CoA + 1 CoA => 1 acetyl-CoA + 1 succinyl-CoA." [] xref: EC:2.3.1.174 xref: GO:0033812 "molecular_function:3-oxoadipyl-CoA thiolase activity" relationship: has_input_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_input_compound UPa:UPC02232 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipyl-CoA relationship: has_output_compound UPa:UPC00024 {cardinality="1", is_alternate="False", is_primary="True"} ! acetyl-CoA relationship: has_output_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="True"} ! succinyl-CoA relationship: part_of UPa:ULS00101 {cardinality="1", order="2"} ! acetyl-CoA and succinyl-CoA from 3-oxoadipate [Term] id: UPa:UER00264 name: 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1 namespace: enzymatic_reaction def: "1 3,4-dihydroxybenzoate + 1 O(2) => 1 3-carboxy-cis,cis-muconate." [] xref: EC:1.13.11.3 xref: GO:0018578 "molecular_function:protocatechuate 3,4-dioxygenase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC01163 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-cis,cis-muconate relationship: part_of UPa:ULS00102 {cardinality="1", order="1"} ! 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00265 name: 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 namespace: enzymatic_reaction def: "1 3-carboxy-cis,cis-muconate => 1 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate." [] xref: EC:5.5.1.2 xref: GO:0047472 "molecular_function:3-carboxy-cis,cis-muconate cycloisomerase activity" relationship: has_input_compound UPa:UPC01163 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-carboxy-cis,cis-muconate relationship: has_output_compound UPa:UPC01278 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: part_of UPa:ULS00130 {cardinality="1", order="1"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate [Term] id: UPa:UER00266 name: 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 2/2 namespace: enzymatic_reaction def: "1 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 1 5-oxo-4,5-dihydro-2-furylacetate + 1 CO(2)." [] xref: EC:4.1.1.44 xref: GO:0047575 "molecular_function:4-carboxymuconolactone decarboxylase activity" relationship: has_input_compound UPa:UPC01278 {cardinality="1", is_alternate="False", is_primary="True"} ! 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC03586 {cardinality="1", is_alternate="False", is_primary="True"} ! 5-oxo-4,5-dihydro-2-furylacetate relationship: part_of UPa:ULS00130 {cardinality="1", order="2"} ! 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate [Term] id: UPa:UER00267 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 1/4 namespace: enzymatic_reaction def: "3,4-dihydroxybenzoate + H(+) + O(2) + [NADH or NADPH] => CO(2) + H(2)O + benzene-1,2,4-triol + [NAD(+) or NADP(+)]." [] xref: EC:1.13.11 xref: GO:0016702 "molecular_function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" xref: GO:0018542 "molecular_function:2,3-dihydroxy DDT 1,2-dioxygenase activity" xref: GO:0018555 "molecular_function:phenanthrene dioxygenase activity" xref: GO:0018556 "molecular_function:2,2',3-trihydroxybiphenyl dioxygenase activity" xref: GO:0018557 "molecular_function:1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity" xref: GO:0018558 "molecular_function:5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity" xref: GO:0018559 "molecular_function:1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity" xref: GO:0018560 "molecular_function:protocatechuate 3,4-dioxygenase type II activity" xref: GO:0018561 "molecular_function:2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity" xref: GO:0018562 "molecular_function:3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity" xref: GO:0018563 "molecular_function:2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity" xref: GO:0018564 "molecular_function:carbazole 1,9a-dioxygenase activity" xref: GO:0018565 "molecular_function:dihydroxydibenzothiophene dioxygenase activity" xref: GO:0018566 "molecular_function:1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity" xref: GO:0018567 "molecular_function:styrene dioxygenase activity" xref: GO:0018568 "molecular_function:3,4-dihydroxyphenanthrene dioxygenase activity" xref: GO:0018569 "molecular_function:hydroquinone 1,2-dioxygenase activity" xref: GO:0018570 "molecular_function:p-cumate 2,3-dioxygenase activity" xref: GO:0018571 "molecular_function:2,3-dihydroxy-p-cumate dioxygenase activity" xref: GO:0018572 "molecular_function:3,5-dichlorocatechol 1,2-dioxygenase activity" xref: GO:0018573 "molecular_function:2-aminophenol 1,6-dioxygenase activity" xref: GO:0018574 "molecular_function:2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity" xref: GO:0018575 "molecular_function:chlorocatechol 1,2-dioxygenase activity" xref: GO:0019114 "molecular_function:catechol dioxygenase activity" xref: GO:0019117 "molecular_function:dihydroxyfluorene dioxygenase activity" xref: GO:0034543 "molecular_function:5-aminosalicylate dioxygenase activity" xref: GO:0034803 "molecular_function:3-hydroxy-2-naphthoate 2,3-dioxygenase activity" xref: GO:0034806 "molecular_function:benzo(a)pyrene 11,12-dioxygenase activity" xref: GO:0034808 "molecular_function:benzo(a)pyrene 4,5-dioxygenase activity" xref: GO:0034810 "molecular_function:4,5-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034811 "molecular_function:benzo(a)pyrene 9,10-dioxygenase activity" xref: GO:0034812 "molecular_function:9,10-dihydroxybenzo(a)pyrene dioxygenase activity" xref: GO:0034813 "molecular_function:benzo(a)pyrene 7,8-dioxygenase activity" xref: GO:0034814 "molecular_function:7,8-dihydroxy benzo(a)pyrene dioxygenase activity" xref: GO:0034827 "molecular_function:1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity" xref: GO:0034834 "molecular_function:2-mercaptobenzothiazole dioxygenase activity" xref: GO:0034895 "molecular_function:pyridine-3,4-diol dioxygenase activity" xref: GO:0034920 "molecular_function:pyrene dioxygenase activity" xref: GO:0034922 "molecular_function:4,5-dihydroxypyrene dioxygenase activity" xref: GO:0034934 "molecular_function:phenanthrene-4-carboxylate dioxygenase activity" xref: GO:0034935 "molecular_function:tetrachlorobenzene dioxygenase activity" xref: GO:0034936 "molecular_function:4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity" xref: GO:0034955 "molecular_function:2,3-dihydroxydiphenyl ether dioxygenase activity" xref: GO:0034956 "molecular_function:diphenyl ether 1,2-dioxygenase activity" xref: GO:0036403 "molecular_function:arachidonate 8(S)-lipoxygenase activity" xref: GO:0047074 "molecular_function:4-hydroxycatechol 1,2-dioxygenase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC00230 {cardinality="1", is_alternate="False", is_primary="True"} ! 3,4-dihydroxybenzoate relationship: has_output_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: part_of UPa:ULS00103 {cardinality="1", order="1"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00268 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 2/4 namespace: enzymatic_reaction def: "1 O(2) + 1 benzene-1,2,4-triol => 1 3-hydroxy-cis,cis-muconate." [] xref: EC:1.13.11.37 xref: GO:0018581 "molecular_function:hydroxyquinol 1,2-dioxygenase activity" relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC02814 {cardinality="1", is_alternate="False", is_primary="True"} ! benzene-1,2,4-triol relationship: has_output_compound UPa:UPC03676 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-cis,cis-muconate relationship: part_of UPa:ULS00103 {cardinality="1", order="2"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00269 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 3/4 namespace: enzymatic_reaction def: "1 3-hydroxy-cis,cis-muconate => 1 maleylacetate." [] relationship: has_input_compound UPa:UPC03676 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-hydroxy-cis,cis-muconate relationship: has_output_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: part_of UPa:ULS00103 {cardinality="1", order="3"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00270 name: L-ornithine and urea from L-arginine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 L-arginine => 1 L-ornithine + 1 urea." [] xref: EC:3.5.3.1 xref: GO:0004053 "molecular_function:arginase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="True"} ! urea relationship: part_of UPa:ULS00177 {cardinality="1", order="1"} ! L-ornithine and urea from L-arginine [Term] id: UPa:UER00271 name: L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1 namespace: enzymatic_reaction def: "1 L-ornithine + 1 carbamoyl phosphate => 1 L-citrulline + 1 phosphate." [] xref: EC:2.1.3.3 xref: GO:0004585 "molecular_function:ornithine carbamoyltransferase activity" relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_input_compound UPa:UPC00169 {cardinality="1", is_alternate="False", is_primary="True"} ! carbamoyl phosphate relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: part_of UPa:ULS00178 {cardinality="1", order="1"} ! L-citrulline from L-ornithine and carbamoyl phosphate [Term] id: UPa:UER00272 name: (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 L-aspartate + 1 L-citrulline => 1 (N(omega)-L-arginino)succinate + 1 AMP + 1 diphosphate." [] xref: EC:6.3.4.5 xref: GO:0004055 "molecular_function:argininosuccinate synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00049 {cardinality="1", is_alternate="False", is_primary="True"} ! L-aspartate relationship: has_input_compound UPa:UPC00327 {cardinality="1", is_alternate="False", is_primary="True"} ! L-citrulline relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: part_of UPa:ULS00179 {cardinality="1", order="1"} ! (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline [Term] id: UPa:UER00273 name: L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1 namespace: enzymatic_reaction def: "1 (N(omega)-L-arginino)succinate => 1 L-arginine + 1 fumarate." [] xref: EC:4.3.2.1 xref: GO:0004056 "molecular_function:argininosuccinate lyase activity" relationship: has_input_compound UPa:UPC03406 {cardinality="1", is_alternate="False", is_primary="True"} ! (N(omega)-L-arginino)succinate relationship: has_output_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00122 {cardinality="1", is_alternate="False", is_primary="True"} ! fumarate relationship: part_of UPa:ULS00180 {cardinality="1", order="1"} ! L-arginine and fumarate from (N(omega)-L-arginino)succinate [Term] id: UPa:UER00274 name: UDP from UMP (UMK/CMK route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 UMP => 1 ADP + 1 UDP." [] xref: EC:2.7.4.14 xref: GO:0004127 "molecular_function:cytidylate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: part_of UPa:ULS00105 {cardinality="1", order="1"} ! UDP from UMP (UMK/CMK route) [Term] id: UPa:UER00275 name: UDP from UMP (UMPK route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 UMP => 1 ADP + 1 UDP." [] xref: EC:2.7.4.22 xref: GO:0033862 "molecular_function:UMP kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00105 {cardinality="1", is_alternate="False", is_primary="True"} ! UMP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: part_of UPa:ULS00106 {cardinality="1", order="1"} ! UDP from UMP (UMPK route) [Term] id: UPa:UER00276 name: CTP from UDP: step 1/2 namespace: enzymatic_reaction def: "1 ATP + 1 UDP => 1 ADP + 1 UTP." [] xref: EC:2.7.4.6 xref: GO:0004550 "molecular_function:nucleoside diphosphate kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00015 {cardinality="1", is_alternate="False", is_primary="True"} ! UDP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00075 {cardinality="1", is_alternate="False", is_primary="True"} ! UTP relationship: part_of UPa:ULS00107 {cardinality="1", order="1"} ! CTP from UDP [Term] id: UPa:UER00277 name: CTP from UDP: step 2/2 namespace: enzymatic_reaction def: "1 ATP + 1 NH(3) + 1 UTP => 1 ADP + 1 CTP + 1 phosphate." [] xref: EC:6.3.4.2 xref: GO:0003883 "molecular_function:CTP synthase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00075 {cardinality="1", is_alternate="False", is_primary="True"} ! UTP relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00009 {cardinality="1", is_alternate="False", is_primary="False"} ! phosphate relationship: has_output_compound UPa:UPC00063 {cardinality="1", is_alternate="False", is_primary="True"} ! CTP relationship: part_of UPa:ULS00107 {cardinality="1", order="2"} ! CTP from UDP [Term] id: UPa:UER00278 name: 3-oxoadipate from 3,4-dihydroxybenzoate: step 4/4 namespace: enzymatic_reaction def: "H(+) + maleylacetate + [NADH or NADPH] => 3-oxoadipate + [NAD(+) or NADP(+)]." [] xref: EC:1.3.1.32 xref: GO:0018506 "molecular_function:maleylacetate reductase activity" relationship: has_input_compound UPa:UPC00004 {cardinality="1", is_alternate="True", is_primary="False"} ! NADH relationship: has_input_compound UPa:UPC00005 {cardinality="1", is_alternate="True", is_primary="False"} ! NADPH relationship: has_input_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_input_compound UPa:UPC02222 {cardinality="1", is_alternate="False", is_primary="True"} ! maleylacetate relationship: has_output_compound UPa:UPC00003 {cardinality="1", is_alternate="True", is_primary="False"} ! NAD(+) relationship: has_output_compound UPa:UPC00006 {cardinality="1", is_alternate="True", is_primary="False"} ! NADP(+) relationship: has_output_compound UPa:UPC00846 {cardinality="1", is_alternate="False", is_primary="True"} ! 3-oxoadipate relationship: part_of UPa:ULS00103 {cardinality="1", order="4"} ! 3-oxoadipate from 3,4-dihydroxybenzoate [Term] id: UPa:UER00279 name: L-glutamate and succinate from L-arginine: step 1/5 namespace: enzymatic_reaction def: "1 L-arginine + 1 succinyl-CoA => 1 CoA + 1 N(2)-succinyl-L-arginine." [] xref: EC:2.3.1.109 xref: GO:0008791 "molecular_function:arginine N-succinyltransferase activity" relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_input_compound UPa:UPC00091 {cardinality="1", is_alternate="False", is_primary="False"} ! succinyl-CoA relationship: has_output_compound UPa:UPC00010 {cardinality="1", is_alternate="False", is_primary="False"} ! CoA relationship: has_output_compound UPa:UPC03296 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-arginine relationship: part_of UPa:ULS00109 {cardinality="1", order="1"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00280 name: L-glutamate and succinate from L-arginine: step 2/5 namespace: enzymatic_reaction def: "2 H(2)O + 1 N(2)-succinyl-L-arginine => 1 CO(2) + 1 N(2)-succinyl-L-ornithine + 2 NH(3)." [] xref: EC:3.5.3.23 xref: GO:0009015 "molecular_function:N-succinylarginine dihydrolase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC03296 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC03415 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-ornithine relationship: part_of UPa:ULS00109 {cardinality="1", order="2"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00281 name: L-glutamate and succinate from L-arginine: step 3/5 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 N(2)-succinyl-L-ornithine => 1 L-glutamate + 1 N-succinyl-L-glutamate 5-semialdehyde." [] xref: EC:2.6.1.81 xref: GO:0043825 "molecular_function:succinylornithine transaminase activity" relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC03415 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-ornithine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC05932 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: part_of UPa:ULS00109 {cardinality="1", order="3"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00282 name: L-glutamate and succinate from L-arginine: step 4/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-succinyl-L-glutamate 5-semialdehyde + 1 NAD(+) => 1 H(+) + 1 N(2)-succinyl-L-glutamic acid + 1 NADH." [] xref: EC:1.2.1.71 xref: GO:0043824 "molecular_function:succinylglutamate-semialdehyde dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC05932 {cardinality="1", is_alternate="False", is_primary="True"} ! N-succinyl-L-glutamate 5-semialdehyde relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC05931 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-glutamic acid relationship: part_of UPa:ULS00109 {cardinality="1", order="4"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00283 name: L-glutamate and succinate from L-arginine: step 5/5 namespace: enzymatic_reaction def: "1 H(2)O + 1 N(2)-succinyl-L-glutamic acid => 1 L-glutamate + 1 succinate." [] xref: EC:3.5.1.96 xref: GO:0009017 "molecular_function:succinylglutamate desuccinylase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC05931 {cardinality="1", is_alternate="False", is_primary="True"} ! N(2)-succinyl-L-glutamic acid relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="True"} ! L-glutamate relationship: has_output_compound UPa:UPC00042 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate relationship: part_of UPa:ULS00109 {cardinality="1", order="5"} ! L-glutamate and succinate from L-arginine [Term] id: UPa:UER00284 name: agmatine from L-arginine: step 1/1 namespace: enzymatic_reaction def: "1 L-arginine => 1 CO(2) + 1 agmatine." [] xref: EC:4.1.1.19 xref: GO:0008792 "molecular_function:arginine decarboxylase activity" relationship: has_input_compound UPa:UPC00062 {cardinality="1", is_alternate="False", is_primary="True"} ! L-arginine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: part_of UPa:ULS00110 {cardinality="1", order="1"} ! agmatine from L-arginine [Term] id: UPa:UER00285 name: N-carbamoylputrescine from agmatine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 agmatine => 1 N-carbamoylputrescine + 1 NH(3)." [] xref: EC:3.5.3.12 xref: GO:0047632 "molecular_function:agmatine deiminase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00436 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylputrescine relationship: part_of UPa:ULS00111 {cardinality="1", order="1"} ! N-carbamoylputrescine from agmatine [Term] id: UPa:UER00286 name: putrescine from N-carbamoylputrescine (amidase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 N-carbamoylputrescine => 1 CO(2) + 1 NH(3) + 1 putrescine." [] xref: EC:3.5.1.53 xref: GO:0050126 "molecular_function:N-carbamoylputrescine amidase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00436 {cardinality="1", is_alternate="False", is_primary="True"} ! N-carbamoylputrescine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00468 {cardinality="1", order="1"} ! putrescine from N-carbamoylputrescine (amidase route) [Term] id: UPa:UER00287 name: putrescine from agmatine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 agmatine => 1 putrescine + 1 urea." [] xref: EC:3.5.3.11 xref: GO:0008783 "molecular_function:agmatinase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00179 {cardinality="1", is_alternate="False", is_primary="True"} ! agmatine relationship: has_output_compound UPa:UPC00086 {cardinality="1", is_alternate="False", is_primary="False"} ! urea relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00112 {cardinality="1", order="1"} ! putrescine from agmatine [Term] id: UPa:UER00288 name: putrescine from L-ornithine: step 1/1 namespace: enzymatic_reaction def: "1 L-ornithine => 1 CO(2) + 1 putrescine." [] xref: EC:4.1.1.17 xref: GO:0004586 "molecular_function:ornithine decarboxylase activity" relationship: has_input_compound UPa:UPC00077 {cardinality="1", is_alternate="False", is_primary="True"} ! L-ornithine relationship: has_output_compound UPa:UPC00011 {cardinality="1", is_alternate="False", is_primary="False"} ! CO(2) relationship: has_output_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: part_of UPa:ULS00113 {cardinality="1", order="1"} ! putrescine from L-ornithine [Term] id: UPa:UER00289 name: 4-aminobutanal from putrescine (amine oxidase route): step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 O(2) + 1 putrescine => 1 4-aminobutanal + 1 H(2)O(2) + 1 NH(3)." [] xref: EC:1.4.3.10 xref: GO:0050232 "molecular_function:putrescine oxidase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00007 {cardinality="1", is_alternate="False", is_primary="False"} ! O(2) relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_output_compound UPa:UPC00027 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O(2) relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: part_of UPa:ULS00114 {cardinality="1", order="1"} ! 4-aminobutanal from putrescine (amine oxidase route) [Term] id: UPa:UER00290 name: 4-aminobutanal from putrescine (transaminase route): step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 putrescine => 1 4-aminobutanal + 1 L-glutamate." [] xref: EC:2.6.1.82 xref: GO:0033094 "molecular_function:butane-1,4-diamine:2-oxoglutarate aminotransferase activity" relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00134 {cardinality="1", is_alternate="False", is_primary="True"} ! putrescine relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: part_of UPa:ULS00115 {cardinality="1", order="1"} ! 4-aminobutanal from putrescine (transaminase route) [Term] id: UPa:UER00291 name: 1,3-diaminopropane and 4-aminobutanal from spermidine: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 acceptor + 1 spermidine => 1 1,3-diaminopropane + 1 4-aminobutanal + 1 reduced acceptor." [] xref: EC:1.5.99.6 xref: GO:0050289 "molecular_function:spermidine dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00028 {cardinality="1", is_alternate="False", is_primary="False"} ! acceptor relationship: has_input_compound UPa:UPC00315 {cardinality="1", is_alternate="False", is_primary="True"} ! spermidine relationship: has_output_compound UPa:UPC00030 {cardinality="1", is_alternate="False", is_primary="False"} ! reduced acceptor relationship: has_output_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00986 {cardinality="1", is_alternate="False", is_primary="True"} ! 1,3-diaminopropane relationship: part_of UPa:ULS00135 {cardinality="1", order="1"} ! 1,3-diaminopropane and 4-aminobutanal from spermidine [Term] id: UPa:UER00292 name: 4-aminobutanoate from 4-aminobutanal: step 1/1 namespace: enzymatic_reaction def: "1 4-aminobutanal + 1 H(2)O + 1 NAD(+) => 1 4-aminobutanoate + 1 H(+) + 1 NADH." [] xref: EC:1.2.1.19 xref: GO:0019145 "molecular_function:aminobutyraldehyde dehydrogenase activity" xref: GO:0033737 "molecular_function:1-pyrroline dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00555 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanal relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00334 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanoate relationship: part_of UPa:ULS00133 {cardinality="1", order="1"} ! 4-aminobutanoate from 4-aminobutanal [Term] id: UPa:UER00293 name: succinate semialdehyde from 4-aminobutanoate: step 1/1 namespace: enzymatic_reaction def: "1 2-oxoglutarate + 1 4-aminobutanoate => 1 L-glutamate + 1 succinate semialdehyde." [] xref: EC:2.6.1.19 xref: GO:0003867 "molecular_function:4-aminobutyrate transaminase activity" relationship: has_input_compound UPa:UPC00026 {cardinality="1", is_alternate="False", is_primary="False"} ! 2-oxoglutarate relationship: has_input_compound UPa:UPC00334 {cardinality="1", is_alternate="False", is_primary="True"} ! 4-aminobutanoate relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00232 {cardinality="1", is_alternate="False", is_primary="True"} ! succinate semialdehyde relationship: part_of UPa:ULS00134 {cardinality="1", order="1"} ! succinate semialdehyde from 4-aminobutanoate [Term] id: UPa:UER00295 name: XMP from IMP: step 1/1 namespace: enzymatic_reaction def: "1 H(2)O + 1 IMP + 1 NAD(+) => 1 H(+) + 1 NADH + 1 XMP." [] xref: EC:1.1.1.205 xref: GO:0003938 "molecular_function:IMP dehydrogenase activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00003 {cardinality="1", is_alternate="False", is_primary="False"} ! NAD(+) relationship: has_input_compound UPa:UPC00130 {cardinality="1", is_alternate="False", is_primary="True"} ! IMP relationship: has_output_compound UPa:UPC00004 {cardinality="1", is_alternate="False", is_primary="False"} ! NADH relationship: has_output_compound UPa:UPC00080 {cardinality="1", is_alternate="False", is_primary="False"} ! H(+) relationship: has_output_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: part_of UPa:ULS00117 {cardinality="1", order="1"} ! XMP from IMP [Term] id: UPa:UER00296 name: GMP from XMP (L-Gln route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 H(2)O + 1 L-glutamine + 1 XMP => 1 AMP + 1 GMP + 1 L-glutamate + 1 diphosphate." [] xref: EC:6.3.5.2 xref: GO:0003921 "molecular_function:GMP synthase activity" xref: GO:0003922 "molecular_function:GMP synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00001 {cardinality="1", is_alternate="False", is_primary="False"} ! H(2)O relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00064 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamine relationship: has_input_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00025 {cardinality="1", is_alternate="False", is_primary="False"} ! L-glutamate relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: part_of UPa:ULS00118 {cardinality="1", order="1"} ! GMP from XMP (L-Gln route) [Term] id: UPa:UER00297 name: GMP from XMP (ammonia route): step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 NH(3) + 1 XMP => 1 AMP + 1 GMP + 1 diphosphate." [] xref: EC:6.3.5.2 xref: GO:0003921 "molecular_function:GMP synthase activity" xref: GO:0003922 "molecular_function:GMP synthase (glutamine-hydrolyzing) activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00014 {cardinality="1", is_alternate="False", is_primary="False"} ! NH(3) relationship: has_input_compound UPa:UPC00655 {cardinality="1", is_alternate="False", is_primary="True"} ! XMP relationship: has_output_compound UPa:UPC00013 {cardinality="1", is_alternate="False", is_primary="False"} ! diphosphate relationship: has_output_compound UPa:UPC00020 {cardinality="1", is_alternate="False", is_primary="False"} ! AMP relationship: has_output_compound UPa:UPC00144 {cardinality="1", is_alternate="False", is_primary="True"} ! GMP relationship: part_of UPa:ULS00119 {cardinality="1", order="1"} ! GMP from XMP (ammonia route) [Term] id: UPa:UER00298 name: pyridoxal 5'-phosphate from pyridoxal: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 pyridoxal => 1 ADP + 1 pyridoxal 5'-phosphate." [] xref: EC:2.7.1.35 xref: GO:0008478 "molecular_function:pyridoxal kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00250 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00018 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxal 5'-phosphate relationship: part_of UPa:ULS00120 {cardinality="1", order="1"} ! pyridoxal 5'-phosphate from pyridoxal [Term] id: UPa:UER00299 name: pyridoxamine 5'-phosphate from pyridoxamine: step 1/1 namespace: enzymatic_reaction def: "1 ATP + 1 pyridoxamine => 1 ADP + 1 pyridoxamine 5'-phosphate." [] xref: EC:2.7.1.35 xref: GO:0008478 "molecular_function:pyridoxal kinase activity" relationship: has_input_compound UPa:UPC00002 {cardinality="1", is_alternate="False", is_primary="False"} ! ATP relationship: has_input_compound UPa:UPC00534 {cardinality="1", is_alternate="False", is_primary="True"} ! pyridoxamine relationship: has_output_compound UPa:UPC00008 {cardinality="1", is_alternate="False", is_primary="False"} ! ADP relationship: has_output_compound UPa:UPC00647 {cardinality="1", is_alternate="False", is_primary="