hugo_symbol residue reference_amino_acid amino_acid_position cluster pdb_chains class variant_amino_acid q_value qvalue_pancan qvaluect p_value tumor_count tumor_type_count tumor_type_composition indel_size transcript_id transcript_id_version type missense_count trunc_count inframe_count splice_count total_count missense_fraction trunc_fraction inframe_fraction splice_fraction NRAS Q61 Q:422 61 P:2|R:204|H:27|*:1|K:142|L:46 0 0 0 422 thymus:3|biliary_tract:5|liver:1|adrenal_gland:1|skin:187|bowel:35|stomach:3|bone:1|testis:9|brain:6|blood:37|head_neck:3|lung:17|kidney:1|ovary:5|unk:11|uterus:5|thyroid:71|pancreas:2|bladder:8|soft_tissue:11 ENST00000369535 4 single residue 421.0 1.0 0.0 0.0 422.0 0.9976303317535545 0.002369668246445498 0.0 0.0 PIK3CA E545 E:633 545 Q:20|A:12|D:5|G:21|K:575 0 0 0 633 cervix:34|biliary_tract:8|liver:1|bowel:97|skin:7|stomach:35|testis:2|brain:22|head_neck:48|vulva:1|lung:51|kidney:8|ovary:5|uterus:30|unk:1|thyroid:3|pancreas:5|bladder:90|prostate:8|penis:3|breast:174 ENST00000263967 3 single residue 633.0 0.0 0.0 0.0 633.0 1.0 0.0 0.0 0.0 IDH1 R132 R:766 132 C:139|S:16|G:28|H:570|I:1|L:12 0 0 0 766 thymus:1|biliary_tract:57|liver:4|adrenal_gland:1|skin:25|bowel:5|bone:6|brain:612|blood:23|head_neck:2|lung:8|unk:2|thyroid:1|pancreas:2|bladder:2|prostate:11|soft_tissue:2|breast:2 ENST00000345146 2 single residue 766.0 0.0 0.0 0.0 766.0 1.0 0.0 0.0 0.0 PIK3CA H1047 H:647 1047 Q:7|R:537|Y:18|L:85 0 0 0 647 cervix:4|biliary_tract:3|liver:3|adrenal_gland:1|bowel:54|skin:5|stomach:28|brain:27|head_neck:25|lung:17|kidney:5|ovary:9|uterus:51|unk:5|thyroid:5|pancreas:7|bladder:20|soft_tissue:11|prostate:6|breast:361 ENST00000263967 3 single residue 647.0 0.0 0.0 0.0 647.0 1.0 0.0 0.0 0.0 BRAF V600 V:897 600 R:4|E:833|V:4|G:3|K:24|M:29 0 0 0 897 biliary_tract:4|skin:357|bowel:113|stomach:1|brain:20|blood:11|head_neck:2|lung:33|kidney:1|ovary:2|lymph:1|unk:21|uterus:1|thyroid:316|pancreas:10|bladder:2|soft_tissue:1|breast:1 ENST00000288602 6 single residue 897.0 0.0 0.0 0.0 897.0 1.0 0.0 0.0 0.0 EGFR L858 L:144 858 R:144 0 3.41122698464838e-276 0 144 lung:143|bowel:1 ENST00000275493 2 single residue 144.0 0.0 0.0 0.0 144.0 1.0 0.0 0.0 0.0 TP53 R175 R:416 175 C:8|G:14|H:386|L:8 0 0 1.74787121081315e-111 416 cervix:1|biliary_tract:5|liver:1|adrenal_gland:1|bowel:108|skin:2|stomach:63|brain:33|head_neck:24|blood:1|lung:28|kidney:2|ovary:21|lymph:1|uterus:14|unk:4|thyroid:2|pancreas:39|bladder:11|prostate:14|soft_tissue:12|breast:29 ENST00000269305 4 single residue 416.0 0.0 0.0 0.0 416.0 1.0 0.0 0.0 0.0 KRAS Q61 Q:190 61 P:2|A:1|R:37|E:1|H:108|K:20|L:21 0 0 4.66285743967654e-165 190 biliary_tract:8|liver:1|bowel:31|skin:2|stomach:5|testis:6|brain:1|blood:17|lung:28|uterus:4|unk:2|thyroid:8|ampulla_of_vater:1|pancreas:64|bladder:5|prostate:4|soft_tissue:1|penis:1|breast:1 ENST00000311936 3 single residue 190.0 0.0 0.0 0.0 190.0 1.0 0.0 0.0 0.0 KRAS G13 G:264 13 A:1|R:2|C:32|D:214|E:3|V:6|G:6 0 0 5.49064695117002e-287 264 cervix:4|biliary_tract:4|liver:1|bowel:130|skin:2|stomach:17|testis:1|brain:1|blood:12|lung:57|lymph:3|ovary:1|uterus:12|unk:5|ampulla_of_vater:1|pancreas:7|bladder:3|soft_tissue:2|breast:1 ENST00000311936 3 single residue 264.0 0.0 0.0 0.0 264.0 1.0 0.0 0.0 0.0 TP53 R248 R:560 248 P:11|Q:292|R:6|W:222|G:8|L:21 0 0 7.14521039740845e-116 560 thymus:1|biliary_tract:2|liver:5|bowel:98|skin:27|stomach:70|bone:1|brain:54|head_neck:28|blood:4|lung:51|kidney:4|ovary:32|lymph:6|uterus:33|unk:10|ampulla_of_vater:1|pancreas:32|bladder:42|prostate:17|soft_tissue:8|breast:34 ENST00000269305 4 single residue 560.0 0.0 0.0 0.0 560.0 1.0 0.0 0.0 0.0 KRAS G12 G:2175 12 A:134|R:166|C:384|S:68|D:757|V:657|F:6|G:1|I:1|L:1 0 0 0 2175 thymus:2|skin:4|stomach:40|testis:19|vulva:1|kidney:5|lymph:2|uterus:84|ampulla_of_vater:10|pancreas:745|soft_tissue:8|cervix:15|biliary_tract:21|liver:1|bowel:500|bone:1|brain:6|blood:13|head_neck:3|lung:570|ovary:25|unk:42|thyroid:3|bladder:36|prostate:4|breast:15 ENST00000311936 3 single residue 2175.0 0.0 0.0 0.0 2175.0 1.0 0.0 0.0 0.0 TP53 R273 R:609 273 P:5|C:283|S:12|G:2|H:251|L:56 0 0 2.49690107064652e-137 609 thymus:1|biliary_tract:4|liver:3|adrenal_gland:1|bowel:105|skin:2|stomach:74|bone:3|brain:113|head_neck:29|blood:5|lung:78|kidney:7|ovary:37|lymph:3|uterus:30|unk:6|thyroid:3|ampulla_of_vater:1|pancreas:27|bladder:11|prostate:18|soft_tissue:5|breast:43 ENST00000269305 4 single residue 609.0 0.0 0.0 0.0 609.0 1.0 0.0 0.0 0.0 PIK3CA E542 E:372 542 A:6|Q:5|V:3|G:2|K:356 0 0 4.73341083892578e-218 372 cervix:16|thymus:1|biliary_tract:3|liver:1|bowel:45|skin:4|stomach:16|testis:2|brain:10|head_neck:31|vulva:1|lung:32|kidney:8|ovary:2|lymph:1|uterus:22|unk:6|thyroid:2|ampulla_of_vater:1|pancreas:2|bladder:46|prostate:5|soft_tissue:3|breast:112 ENST00000263967 3 single residue 372.0 0.0 0.0 0.0 372.0 1.0 0.0 0.0 0.0 AKT1 E17 E:149 17 *:1|K:148 1.14602579830599e-288 1.14602579830599e-288 2.63950903249508e-204 149 cervix:3|biliary_tract:1|liver:1|bowel:13|skin:1|stomach:3|brain:2|head_neck:3|lung:8|ovary:2|lymph:1|uterus:8|unk:5|thyroid:3|pancreas:1|bladder:6|prostate:8|breast:80 ENST00000349310 3 single residue 148.0 1.0 0.0 0.0 149.0 0.9932885906040269 0.006711409395973154 0.0 0.0 GNAS R201 R:139 201 C:65|S:3|H:69|L:2 7.46750176711196e-257 7.46750176711196e-257 3.73574916837927e-122 139 cervix:3|biliary_tract:3|liver:4|adrenal_gland:1|bowel:53|skin:1|stomach:17|bone:1|head_neck:1|lung:9|ovary:2|unk:5|ampulla_of_vater:1|pancreas:35|bladder:1|prostate:1|breast:1 ENST00000371085 3 single residue 139.0 0.0 0.0 0.0 139.0 1.0 0.0 0.0 0.0 FGFR3 S249 S:114 249 C:114 3.49459925534527e-229 2.18560576076073e-177 3.49459925534527e-229 114 lung:4|cervix:1|kidney:1|bladder:103|head_neck:5 ENST00000260795 2 single residue 114.0 0.0 0.0 0.0 114.0 1.0 0.0 0.0 0.0 PIK3CA N345 N:98 345 T:4|D:1|H:3|I:7|Y:3|K:79|N:1 3.86928187806421e-219 3.86928187806421e-219 2.20603783559515e-130 98 lung:7|uterus:11|bladder:2|bowel:9|stomach:5|prostate:3|soft_tissue:2|testis:1|brain:3|breast:51|head_neck:4 ENST00000263967 3 single residue 98.0 0.0 0.0 0.0 98.0 1.0 0.0 0.0 0.0 PTEN R130 R:168 130 P:6|Q:72|R:2|S:1|G:44|*:38|L:5 1.91658796865309e-210 1.91658796865309e-210 1.35644920841025e-113 168 cervix:4|biliary_tract:2|bowel:13|skin:5|stomach:3|brain:14|head_neck:4|lung:8|kidney:2|ovary:2|uterus:83|unk:1|thyroid:1|prostate:8|soft_tissue:2|penis:1|pleura:1|breast:14 ENST00000371953 3 single residue 130.0 38.0 0.0 0.0 168.0 0.7738095238095238 0.2261904761904762 0.0 0.0 HRAS Q61 Q:102 61 R:56|H:2|K:28|L:16 8.14542563277525e-210 8.14542563277525e-210 5.53754971603055e-48 102 thymus:1|adrenal_gland:17|skin:11|stomach:1|brain:2|head_neck:11|vulva:1|lung:3|thyroid:22|bladder:19|prostate:10|soft_tissue:3|breast:1 ENST00000451590 1 single residue 102.0 0.0 0.0 0.0 102.0 1.0 0.0 0.0 0.0 TP53 Y220 Y:152 220 C:127|S:8|D:4|H:6|*:4|N:3 4.53756860311655e-208 4.53756860311655e-208 5.84008000635182e-33 152 liver:7|bowel:7|skin:1|stomach:11|brain:22|head_neck:12|lung:20|kidney:2|ovary:20|uterus:6|unk:2|pancreas:11|bladder:3|prostate:4|soft_tissue:6|breast:18 ENST00000269305 4 single residue 148.0 4.0 0.0 0.0 152.0 0.9736842105263158 0.02631578947368421 0.0 0.0 TP53 G245 G:242 245 A:3|R:7|S:128|C:22|D:50|V:31|N:1 8.54722719468586e-208 8.54722719468586e-208 3.13034901255858e-44 242 cervix:1|biliary_tract:2|liver:3|bowel:49|skin:4|stomach:25|bone:1|brain:17|head_neck:19|lung:40|kidney:3|ovary:15|lymph:1|uterus:7|thyroid:1|ampulla_of_vater:1|pancreas:15|bladder:9|prostate:14|soft_tissue:2|breast:13 ENST00000269305 4 single residue 242.0 0.0 0.0 0.0 242.0 1.0 0.0 0.0 0.0 FBXW7 R465 R:128 465 P:1|C:64|S:2|G:1|H:59|L:1 1.92461558472193e-192 1.92461558472193e-192 5.58175028566437e-83 128 cervix:5|biliary_tract:2|bowel:53|stomach:15|brain:4|head_neck:3|blood:1|lung:6|ovary:2|lymph:1|uterus:25|pancreas:1|bladder:7|pleura:1|breast:2 ENST00000281708 4 single residue 128.0 0.0 0.0 0.0 128.0 1.0 0.0 0.0 0.0 PIK3CA Q546 Q:93 546 P:19|R:31|E:2|H:5|K:35|L:1 1.38151348550833e-185 1.38151348550833e-185 2.67796503151426e-45 93 cervix:1|biliary_tract:1|bowel:21|skin:1|stomach:4|brain:6|head_neck:5|lung:1|ovary:2|uterus:15|unk:1|thyroid:1|bladder:5|soft_tissue:3|prostate:4|breast:22 ENST00000263967 3 single residue 93.0 0.0 0.0 0.0 93.0 1.0 0.0 0.0 0.0 ERBB2 S310 S:113 310 S:1|F:95|Y:17 1.98484785043436e-185 1.98484785043436e-185 2.56043031151985e-109 113 lung:4|cervix:7|ovary:2|biliary_tract:3|unk:3|bladder:56|skin:6|bowel:6|stomach:10|soft_tissue:1|breast:12|head_neck:3 ENST00000269571 5 single residue 113.0 0.0 0.0 0.0 113.0 1.0 0.0 0.0 0.0 GNA11 Q209 Q:59 209 P:1|H:1|L:57 3.53820080128409e-183 1.72149469672423e-101 3.53820080128409e-183 59 eye:52|skin:6|bowel:1 ENST00000078429 4 single residue 59.0 0.0 0.0 0.0 59.0 1.0 0.0 0.0 0.0 GNAQ Q209 Q:65 209 P:42|H:1|L:22 4.59257795185295e-172 1.1413217681395e-115 4.59257795185295e-172 65 eye:57|lung:1|skin:6|testis:1 ENST00000286548 4 single residue 65.0 0.0 0.0 0.0 65.0 1.0 0.0 0.0 0.0 GTF2I L424 L:68 424 H:68 3.8165837042307e-165 7.76583444668287e-138 3.8165837042307e-165 68 thymus:68 ENST00000324896 4 single residue 68.0 0.0 0.0 0.0 68.0 1.0 0.0 0.0 0.0 TP53 R282 R:219 282 P:4|Q:3|R:1|W:201|G:9|L:1 5.73631626869356e-160 5.73631626869356e-160 4.40127678810281e-58 219 cervix:1|thymus:2|biliary_tract:2|liver:1|bowel:60|skin:8|stomach:34|brain:21|head_neck:18|lung:14|kidney:2|ovary:8|lymph:2|uterus:2|pancreas:22|bladder:8|prostate:8|soft_tissue:2|breast:4 ENST00000269305 4 single residue 219.0 0.0 0.0 0.0 219.0 1.0 0.0 0.0 0.0 CTNNB1 S37 S:103 37 P:7|A:9|C:27|F:55|Y:5 2.59381163737272e-157 2.59381163737272e-157 2.51450272616679e-45 103 cervix:2|liver:12|bowel:2|skin:1|stomach:11|brain:5|head_neck:1|lung:25|ovary:1|uterus:27|unk:1|pancreas:3|bladder:7|prostate:4|breast:1 ENST00000349496 5 single residue 103.0 0.0 0.0 0.0 103.0 1.0 0.0 0.0 0.0 CTNNB1 D32 D:81 32 A:3|V:16|G:16|H:6|Y:22|N:18 8.30436601169097e-155 8.30436601169097e-155 3.97021070233949e-61 81 cervix:2|biliary_tract:1|liver:28|adrenal_gland:1|bowel:2|skin:3|stomach:4|brain:6|lung:4|ovary:1|uterus:18|pancreas:2|bladder:1|prostate:8 ENST00000349496 5 single residue 81.0 0.0 0.0 0.0 81.0 1.0 0.0 0.0 0.0 SMAD4 R361 R:124 361 P:1|C:54|S:4|G:3|H:60|L:2 1.13407719335173e-154 1.13407719335173e-154 3.17231292662384e-73 124 cervix:2|biliary_tract:7|bowel:59|skin:1|stomach:17|head_neck:1|lung:5|uterus:1|ampulla_of_vater:1|pancreas:22|bladder:3|prostate:1|breast:4 ENST00000342988 3 single residue 124.0 0.0 0.0 0.0 124.0 1.0 0.0 0.0 0.0 TP53 H179 H:149 179 P:3|Q:12|R:63|D:8|Y:41|L:14|N:8 9.18618200580122e-150 9.18618200580122e-150 1.63027247437287e-26 149 biliary_tract:1|liver:3|bowel:9|skin:6|stomach:11|bone:1|brain:16|head_neck:13|blood:1|lung:33|ovary:6|uterus:6|unk:2|thyroid:1|pancreas:13|bladder:3|prostate:4|soft_tissue:3|breast:17 ENST00000269305 4 single residue 149.0 0.0 0.0 0.0 149.0 1.0 0.0 0.0 0.0 CTNNB1 S33 S:96 33 P:16|A:7|C:32|T:1|F:29|Y:11 1.29715714396544e-144 1.29715714396544e-144 1.6189434824373e-45 96 cervix:1|liver:23|bowel:3|skin:1|stomach:5|brain:8|head_neck:1|lung:11|ovary:3|uterus:24|unk:1|thyroid:1|pancreas:1|bladder:5|prostate:8 ENST00000349496 5 single residue 96.0 0.0 0.0 0.0 96.0 1.0 0.0 0.0 0.0 KRAS A146 A:86 146 P:5|T:65|V:16 5.76478689994657e-140 5.76478689994657e-140 1.13349432187608e-107 86 lung:5|cervix:1|unk:4|pancreas:1|bladder:2|bowel:56|stomach:6|testis:5|blood:6 ENST00000311936 3 single residue 86.0 0.0 0.0 0.0 86.0 1.0 0.0 0.0 0.0 CTNNB1 T41 T:66 41 A:45|I:19|N:2 1.16454574986485e-135 1.16454574986485e-135 2.71536864536504e-31 66 biliary_tract:1|liver:15|adrenal_gland:1|bowel:11|skin:6|lung:5|ovary:1|uterus:8|unk:2|ampulla_of_vater:2|pancreas:1|bladder:1|prostate:10|soft_tissue:2 ENST00000349496 5 single residue 66.0 0.0 0.0 0.0 66.0 1.0 0.0 0.0 0.0 EGFR T790 T:60 790 T:1|M:59 1.11200956013873e-133 1.19383260940355e-93 1.11200956013873e-133 60 lung:59|ovary:1 ENST00000275493 2 single residue 60.0 0.0 0.0 0.0 60.0 1.0 0.0 0.0 0.0 NRAS G12 G:74 12 A:6|R:3|C:11|S:8|D:41|V:5 3.67050868081457e-130 3.67050868081457e-130 1.13403565342994e-61 74 biliary_tract:1|bowel:30|skin:11|stomach:2|testis:4|brain:1|blood:11|head_neck:3|kidney:1|ovary:1|uterus:4|unk:4|bladder:1 ENST00000369535 4 single residue 74.0 0.0 0.0 0.0 74.0 1.0 0.0 0.0 0.0 SF3B1 K700 K:59 700 R:1|E:57|K:1 1.51874215150358e-126 1.51874215150358e-126 2.14299561638893e-85 59 lung:2|kidney:2|lymph:1|thymus:1|biliary_tract:2|pancreas:5|prostate:1|soft_tissue:1|brain:1|breast:28|blood:15 ENST00000335508 6 single residue 59.0 0.0 0.0 0.0 59.0 1.0 0.0 0.0 0.0 TP53 H193 H:123 193 P:8|Q:1|R:54|D:5|Y:31|L:19|N:5 1.47914622326681e-124 1.47914622326681e-124 1.53320819640449e-19 123 cervix:1|thymus:1|liver:6|bowel:3|stomach:9|bone:1|brain:14|head_neck:10|blood:2|lung:18|kidney:3|ovary:9|uterus:7|unk:1|pancreas:7|bladder:6|prostate:4|soft_tissue:3|breast:18 ENST00000269305 4 single residue 123.0 0.0 0.0 0.0 123.0 1.0 0.0 0.0 0.0 ESR1 D538 D:46 538 G:46 1.28855707547783e-123 1.71163529165355e-91 1.28855707547783e-123 46 ovary:1|uterus:2|unk:1|breast:42 ENST00000206249 3 single residue 46.0 0.0 0.0 0.0 46.0 1.0 0.0 0.0 0.0 FBXW7 R505 R:83 505 P:2|C:41|S:1|G:31|H:4|L:4 5.90349136748716e-120 5.90349136748716e-120 9.68248345461949e-29 83 cervix:4|biliary_tract:1|bowel:23|skin:3|stomach:7|brain:1|blood:1|head_neck:9|lung:5|ovary:1|uterus:14|unk:2|pancreas:1|bladder:10|soft_tissue:1 ENST00000281708 4 single residue 83.0 0.0 0.0 0.0 83.0 1.0 0.0 0.0 0.0 IDH2 R172 R:63 172 R:1|S:8|T:1|G:9|W:7|K:33|M:4 1.20402527166582e-117 1.20402527166582e-117 2.5972240937531e-87 63 kidney:1|lymph:8|biliary_tract:9|unk:1|liver:2|bladder:1|bowel:1|bone:1|brain:34|blood:3|head_neck:2 ENST00000330062 3 single residue 63.0 0.0 0.0 0.0 63.0 1.0 0.0 0.0 0.0 U2AF1 S34 S:85 34 F:81|Y:4 4.3504059017074e-116 4.3504059017074e-116 1.32947786922618e-81 85 cervix:2|biliary_tract:2|bowel:1|skin:1|blood:8|head_neck:1|lung:41|lymph:1|uterus:7|unk:1|pancreas:9|bladder:9|prostate:1|breast:1 ENST00000291552 4 single residue 85.0 0.0 0.0 0.0 85.0 1.0 0.0 0.0 0.0 EGFR A289 A:59 289 T:14|D:6|V:37|I:1|N:1 5.81115249692553e-116 3.79364709147765e-80 5.81115249692553e-116 59 lung:2|brain:56|head_neck:1 ENST00000275493 2 single residue 59.0 0.0 0.0 0.0 59.0 1.0 0.0 0.0 0.0 ESR1 Y537 Y:47 537 S:25|C:11|D:1|N:10 6.21076412839154e-115 6.82278397457236e-97 6.21076412839154e-115 47 uterus:7|skin:1|breast:39 ENST00000206249 3 single residue 47.0 0.0 0.0 0.0 47.0 1.0 0.0 0.0 0.0 CTNNB1 S45 S:71 45 P:29|A:2|C:5|F:31|Y:4 2.67102961964491e-111 2.67102961964491e-111 8.15275201375133e-23 71 biliary_tract:4|liver:13|adrenal_gland:6|bowel:9|skin:8|stomach:1|brain:1|lung:5|uterus:4|unk:1|ampulla_of_vater:2|pancreas:4|bladder:6|prostate:6|soft_tissue:1 ENST00000349496 5 single residue 71.0 0.0 0.0 0.0 71.0 1.0 0.0 0.0 0.0 TP53 C176 C:115 176 R:5|S:9|C:1|F:54|W:7|G:5|Y:30|*:4 2.79789123298349e-94 2.79789123298349e-94 1.74584132190386e-17 115 biliary_tract:1|liver:1|bowel:19|stomach:16|bone:2|brain:4|head_neck:9|blood:1|lung:16|kidney:2|lymph:4|ovary:12|uterus:1|unk:1|pancreas:7|bladder:1|prostate:5|breast:13 ENST00000269305 4 single residue 111.0 4.0 0.0 0.0 115.0 0.9652173913043478 0.034782608695652174 0.0 0.0 PIK3CA R88 R:75 88 Q:75 7.11268347015126e-94 7.11268347015126e-94 1.09365352810489e-26 75 lung:1|ovary:1|uterus:23|biliary_tract:1|unk:1|bladder:3|bowel:20|stomach:6|prostate:1|brain:10|breast:5|head_neck:3 ENST00000263967 3 single residue 75.0 0.0 0.0 0.0 75.0 1.0 0.0 0.0 0.0 ERBB3 V104 V:61 104 L:21|M:40 2.90075860561392e-90 2.90075860561392e-90 9.13440422872076e-24 61 cervix:4|uterus:8|biliary_tract:3|pancreas:1|bladder:13|bowel:16|stomach:12|breast:4 ENST00000267101 3 single residue 61.0 0.0 0.0 0.0 61.0 1.0 0.0 0.0 0.0 PIK3CA M1043 M:58 1043 T:4|V:25|I:25|L:4 1.37438573866737e-88 1.37438573866737e-88 2.62784251320464e-22 58 lung:4|uterus:13|thyroid:3|pancreas:1|bladder:1|bowel:7|stomach:2|soft_tissue:1|brain:11|breast:11|head_neck:4 ENST00000263967 3 single residue 58.0 0.0 0.0 0.0 58.0 1.0 0.0 0.0 0.0 TP53 Y163 Y:79 163 C:54|D:3|H:11|*:2|N:9 6.75581008893545e-86 6.75581008893545e-86 2.63487093051757e-22 79 liver:4|bowel:4|skin:1|stomach:4|brain:7|head_neck:9|lung:21|ovary:11|lymph:1|uterus:2|ampulla_of_vater:1|pancreas:2|bladder:1|prostate:3|soft_tissue:2|breast:6 ENST00000269305 4 single residue 77.0 2.0 0.0 0.0 79.0 0.9746835443037974 0.02531645569620253 0.0 0.0 ERBB2 L755 L:44 755 P:5|A:2|S:31|W:1|L:2|M:3 1.41038891943129e-85 1.41038891943129e-85 4.51352278894825e-56 44 lung:6|kidney:1|uterus:3|biliary_tract:1|ampulla_of_vater:1|bladder:3|bowel:4|skin:1|stomach:3|breast:21 ENST00000269571 5 single residue 44.0 0.0 0.0 0.0 44.0 1.0 0.0 0.0 0.0 H3-3A K28 K:33 28 R:1|M:32 5.3294455724506e-83 8.48583170827933e-55 5.3294455724506e-83 33 pancreas:1|brain:32 ENST00000366813 1 single residue 33.0 0.0 0.0 0.0 33.0 1.0 0.0 0.0 0.0 FGFR3 Y373 Y:32 373 C:32 7.46580235069588e-83 1.48233222785227e-62 7.46580235069588e-83 32 kidney:1|bladder:31 ENST00000260795 2 single residue 32.0 0.0 0.0 0.0 32.0 1.0 0.0 0.0 0.0 BRAF G469 G:61 469 A:34|R:8|S:2|E:4|V:11|G:1|*:1 3.65455186277771e-82 3.65455186277771e-82 2.16881343411092e-35 61 biliary_tract:1|adrenal_gland:1|bowel:6|skin:13|stomach:1|brain:2|blood:3|head_neck:1|lung:23|lymph:2|unk:2|uterus:1|thyroid:1|bladder:2|prostate:2 ENST00000288602 6 single residue 60.0 1.0 0.0 0.0 61.0 0.9836065573770492 0.01639344262295082 0.0 0.0 PIK3CA C420 C:46 420 R:46 2.5982410627491e-80 2.5982410627491e-80 4.66563056390319e-29 46 lung:5|ovary:1|uterus:4|biliary_tract:1|unk:1|bowel:7|stomach:2|prostate:2|soft_tissue:1|brain:3|breast:15|head_neck:4 ENST00000263967 3 single residue 46.0 0.0 0.0 0.0 46.0 1.0 0.0 0.0 0.0 HRAS G13 G:50 13 R:22|C:3|S:2|D:6|V:15|I:1|N:1 5.5041445937963e-80 5.5041445937963e-80 6.38273162759684e-28 50 lung:6|thymus:3|unk:1|adrenal_gland:2|bladder:11|skin:7|bowel:1|soft_tissue:1|head_neck:16|breast:2 ENST00000451590 1 single residue 50.0 0.0 0.0 0.0 50.0 1.0 0.0 0.0 0.0 CTNNB1 G34 G:53 34 A:1|R:28|E:8|V:14|*:1|L:1 2.2102778557963e-79 2.2102778557963e-79 6.02037136961261e-33 53 liver:9|adrenal_gland:3|skin:4|bowel:1|stomach:2|brain:4|head_neck:1|lung:8|uterus:15|unk:2|pancreas:1|bladder:1|prostate:2 ENST00000349496 5 single residue 52.0 1.0 0.0 0.0 53.0 0.9811320754716981 0.018867924528301886 0.0 0.0 TP53 I195 I:79 195 S:4|T:42|F:19|I:1|K:1|M:2|N:10 5.3117975300635e-77 5.3117975300635e-77 4.72320226973581e-20 79 liver:3|bowel:4|stomach:7|brain:6|blood:4|head_neck:4|lung:9|ovary:13|uterus:2|ampulla_of_vater:1|pancreas:7|bladder:1|soft_tissue:1|pleura:1|breast:16 ENST00000269305 4 single residue 79.0 0.0 0.0 0.0 79.0 1.0 0.0 0.0 0.0 CDKN2A H83 H:62 83 Q:2|R:4|D:6|Y:48|N:2 1.3094103357572e-75 1.3094103357572e-75 3.01513076625433e-14 62 biliary_tract:3|liver:1|skin:7|bowel:2|stomach:6|brain:3|head_neck:4|vulva:1|lung:12|ovary:2|pancreas:12|bladder:4|soft_tissue:2|breast:3 ENST00000579755 1 single residue 62.0 0.0 0.0 0.0 62.0 1.0 0.0 0.0 0.0 TP53 X187 X:100 187 sp:100 1.82472984264798e-75 1.82472984264798e-75 4.91456896884551e-12 100 liver:1|bowel:7|skin:7|stomach:11|brain:4|head_neck:7|blood:1|lung:20|kidney:1|ovary:11|uterus:2|pancreas:6|bladder:2|soft_tissue:5|prostate:1|breast:14 ENST00000269305 4 splice site 0.0 0.0 0.0 100.0 100.0 0.0 0.0 0.0 1.0 TP53 G266 G:117 266 R:40|T:1|E:35|V:26|*:14|K:1 1.57992511675724e-74 1.57992511675724e-74 3.04186623430253e-09 117 biliary_tract:2|liver:2|skin:7|bowel:12|stomach:6|brain:9|head_neck:8|vulva:1|blood:2|lung:21|kidney:1|ovary:7|lymph:1|unk:1|uterus:5|ampulla_of_vater:1|pancreas:11|bladder:4|soft_tissue:3|prostate:3|pleura:1|breast:9 ENST00000269305 4 single residue 103.0 14.0 0.0 0.0 117.0 0.8803418803418803 0.11965811965811966 0.0 0.0 TP53 R249 R:102 249 S:45|T:11|G:15|W:11|I:1|K:2|M:17 1.28532741635959e-72 1.28532741635959e-72 2.00958962012837e-23 102 liver:13|adrenal_gland:1|bowel:3|skin:3|stomach:6|brain:6|head_neck:6|lung:33|lymph:1|ovary:1|unk:3|uterus:4|thyroid:2|pancreas:5|bladder:3|prostate:4|soft_tissue:1|breast:7 ENST00000269305 4 single residue 102.0 0.0 0.0 0.0 102.0 1.0 0.0 0.0 0.0 SF3B1 R625 R:59 625 C:25|G:1|H:29|L:4 1.5407254801883e-72 1.5407254801883e-72 2.49020674514763e-70 59 eye:27|kidney:1|lymph:1|pancreas:1|bladder:2|bowel:10|skin:7|soft_tissue:1|vulva:3|head_neck:3|blood:2|breast:1 ENST00000335508 6 single residue 59.0 0.0 0.0 0.0 59.0 1.0 0.0 0.0 0.0 BRAF K601 K:38 601 T:1|E:32|N:5 1.94975462848428e-70 1.94975462848428e-70 2.52651634517579e-12 38 biliary_tract:1|skin:8|bowel:2|stomach:2|head_neck:1|blood:1|lung:6|lymph:4|unk:2|uterus:2|thyroid:2|prostate:6|breast:1 ENST00000288602 6 single residue 38.0 0.0 0.0 0.0 38.0 1.0 0.0 0.0 0.0 BRAF D594 D:51 594 E:1|V:2|G:21|H:1|Y:2|N:24 9.78698184667661e-70 9.78698184667661e-70 1.46788660064217e-22 51 cervix:1|biliary_tract:1|adrenal_gland:1|bowel:12|skin:6|stomach:2|testis:1|brain:1|head_neck:1|blood:3|lung:10|lymph:2|unk:3|bladder:6|prostate:1 ENST00000288602 6 single residue 51.0 0.0 0.0 0.0 51.0 1.0 0.0 0.0 0.0 EZH2 Y646 Y:38 646 S:4|C:1|F:13|H:6|Y:1|N:13 6.87377238358676e-69 6.87377238358676e-69 2.49434166183531e-66 38 lymph:23|unk:1|biliary_tract:1|skin:10|bone:3 ENST00000320356 2 single residue 38.0 0.0 0.0 0.0 38.0 1.0 0.0 0.0 0.0 TP53 Y234 Y:68 234 C:42|S:3|D:2|H:9|*:6|N:6 4.21073846121301e-68 4.21073846121301e-68 2.06304592728338e-08 68 biliary_tract:2|liver:2|adrenal_gland:1|bowel:3|skin:2|stomach:5|bone:1|brain:7|head_neck:3|vulva:1|lung:11|kidney:1|ovary:6|unk:2|ampulla_of_vater:1|pancreas:5|bladder:3|prostate:3|soft_tissue:3|breast:6 ENST00000269305 4 single residue 62.0 6.0 0.0 0.0 68.0 0.9117647058823529 0.08823529411764706 0.0 0.0 DNMT3A R882 R:39 882 P:1|C:10|H:28 1.73894288218144e-67 4.64828334151859e-43 1.73894288218144e-67 39 lung:1|lymph:4|bowel:1|pleura:1|brain:1|blood:30|breast:1 ENST00000264709 3 single residue 39.0 0.0 0.0 0.0 39.0 1.0 0.0 0.0 0.0 BCOR N1459 N:36 1459 S:36 2.0435075018722e-67 2.0435075018722e-67 9.59503196297028e-59 36 lung:8|ovary:2|uterus:23|unk:2|bowel:1 ENST00000378444 4 single residue 36.0 0.0 0.0 0.0 36.0 1.0 0.0 0.0 0.0 PPP2R1A P179 P:30 179 R:29|L:1 3.79894395598156e-66 5.13001481701721e-48 3.79894395598156e-66 30 ovary:1|uterus:27|unk:1|soft_tissue:1 ENST00000322088 6 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 RAC1 P29 P:53 29 S:43|T:2|F:1|L:7 1.55867535683403e-65 1.284882354322e-52 1.55867535683403e-65 53 unk:4|uterus:1|thyroid:1|skin:42|soft_tissue:1|head_neck:3|breast:1 ENST00000356142 4 single residue 53.0 0.0 0.0 0.0 53.0 1.0 0.0 0.0 0.0 PIK3CA G118 G:40 118 D:40 1.608288709768e-65 1.608288709768e-65 9.75710432656681e-14 40 cervix:1|bowel:2|stomach:2|brain:8|head_neck:2|lung:2|kidney:1|uterus:8|thyroid:1|ampulla_of_vater:1|pancreas:1|bladder:1|prostate:1|breast:9 ENST00000263967 3 single residue 40.0 0.0 0.0 0.0 40.0 1.0 0.0 0.0 0.0 FBXW7 R479 R:57 479 P:7|Q:31|R:1|G:8|*:8|L:2 4.37689458184735e-63 4.37689458184735e-63 4.82061171777628e-13 57 cervix:4|bowel:12|skin:1|stomach:4|brain:1|head_neck:5|eye:1|lung:4|kidney:1|lymph:1|uterus:12|bladder:8|penis:1|breast:2 ENST00000281708 4 single residue 49.0 8.0 0.0 0.0 57.0 0.8596491228070176 0.14035087719298245 0.0 0.0 TP53 X307 X:77 307 sp:77 1.53643954111284e-62 1.53643954111284e-62 6.85461293441419e-11 77 biliary_tract:1|liver:4|adrenal_gland:1|bowel:9|skin:1|stomach:6|brain:4|head_neck:9|lung:16|kidney:1|ovary:6|unk:3|pancreas:2|bladder:3|prostate:2|soft_tissue:2|breast:7 ENST00000269305 4 splice site 0.0 0.0 0.0 77.0 77.0 0.0 0.0 0.0 1.0 TP53 V173 V:78 173 A:4|E:1|G:4|L:42|M:27 7.25981161558513e-62 7.25981161558513e-62 2.31292701190506e-11 78 liver:1|adrenal_gland:1|bowel:12|skin:1|stomach:10|bone:3|brain:6|head_neck:7|lung:9|lymph:3|ovary:3|uterus:3|unk:2|ampulla_of_vater:1|pancreas:4|bladder:3|prostate:2|pleura:1|breast:6 ENST00000269305 4 single residue 78.0 0.0 0.0 0.0 78.0 1.0 0.0 0.0 0.0 TP53 C238 C:77 238 R:5|S:4|F:23|G:4|W:1|Y:40 7.74651843586856e-62 7.74651843586856e-62 2.91060332337365e-06 77 cervix:1|liver:1|bowel:5|skin:2|stomach:5|brain:8|head_neck:5|blood:2|lung:11|ovary:5|lymph:1|uterus:6|pancreas:8|bladder:6|soft_tissue:3|prostate:3|breast:5 ENST00000269305 4 single residue 77.0 0.0 0.0 0.0 77.0 1.0 0.0 0.0 0.0 PPP2R1A R183 R:51 183 Q:17|W:33|G:1 9.6264551563176e-61 9.6264551563176e-61 3.4386112275086e-14 51 biliary_tract:1|bowel:12|stomach:2|head_neck:3|lung:3|eye:1|ovary:6|uterus:11|unk:1|thyroid:1|pancreas:1|bladder:1|prostate:3|soft_tissue:1|breast:4 ENST00000322088 6 single residue 51.0 0.0 0.0 0.0 51.0 1.0 0.0 0.0 0.0 MYD88 L265 L:37 265 P:37 1.26353661666745e-60 1.26353661666745e-60 4.63294980810544e-44 37 lung:2|peritoneum:1|lymph:19|bladder:1|bowel:1|blood:13 ENST00000396334 3 single residue 37.0 0.0 0.0 0.0 37.0 1.0 0.0 0.0 0.0 TP53 X126 X:75 126 sp:75 5.81977745695617e-59 5.81977745695617e-59 1.38697444775352e-09 75 biliary_tract:1|liver:2|bowel:5|skin:2|stomach:8|bone:1|brain:4|blood:2|head_neck:1|lung:14|kidney:1|ovary:7|uterus:4|unk:2|pancreas:5|bladder:1|prostate:3|soft_tissue:1|breast:11 ENST00000269305 4 splice site 0.0 0.0 0.0 75.0 75.0 0.0 0.0 0.0 1.0 NRAS G13 G:41 13 R:18|S:3|C:2|D:16|F:1|V:1 3.59718742726763e-58 3.59718742726763e-58 6.57089291102781e-18 41 lung:1|lymph:1|biliary_tract:2|unk:1|bladder:1|bowel:10|skin:7|stomach:1|soft_tissue:1|testis:1|brain:2|blood:13 ENST00000369535 4 single residue 41.0 0.0 0.0 0.0 41.0 1.0 0.0 0.0 0.0 TP53 Y205 Y:61 205 C:35|S:6|D:3|F:6|H:8|*:1|N:2 7.4725061476356e-58 7.4725061476356e-58 2.52498121772598e-06 61 biliary_tract:1|liver:4|bowel:7|skin:1|stomach:7|brain:4|head_neck:2|blood:1|lung:9|kidney:1|ovary:2|lymph:3|unk:2|uterus:2|pancreas:6|bladder:1|soft_tissue:1|breast:7 ENST00000269305 4 single residue 60.0 1.0 0.0 0.0 61.0 0.9836065573770492 0.01639344262295082 0.0 0.0 PIK3CA E726 E:55 726 A:2|K:53 1.11290833591147e-57 1.11290833591147e-57 2.43669037215835e-29 55 cervix:3|bowel:5|skin:1|stomach:2|bone:1|brain:1|head_neck:2|lung:6|uterus:1|pancreas:1|bladder:6|prostate:2|breast:24 ENST00000263967 3 single residue 55.0 0.0 0.0 0.0 55.0 1.0 0.0 0.0 0.0 TP53 P151 P:79 151 A:11|R:9|S:36|T:8|F:1|H:13|L:1 1.30026283538923e-57 1.30026283538923e-57 8.2109877333981e-11 79 liver:2|bowel:12|skin:5|stomach:5|brain:4|head_neck:8|blood:1|lung:7|kidney:2|ovary:5|unk:4|uterus:3|thyroid:1|pancreas:6|bladder:4|prostate:2|soft_tissue:2|breast:6 ENST00000269305 4 single residue 79.0 0.0 0.0 0.0 79.0 1.0 0.0 0.0 0.0 EGFR G598 G:33 598 A:5|E:1|V:27 6.32187956175441e-57 3.8948006558789e-37 6.32187956175441e-57 33 lung:1|stomach:1|brain:31 ENST00000275493 2 single residue 33.0 0.0 0.0 0.0 33.0 1.0 0.0 0.0 0.0 TP53 R158 R:106 158 P:11|C:5|S:2|F:1|G:9|H:36|L:42 8.56420853444971e-57 8.56420853444971e-57 4.37814977424256e-51 106 biliary_tract:1|liver:2|bowel:7|skin:1|stomach:5|brain:14|head_neck:2|lung:55|kidney:1|ovary:1|unk:2|uterus:4|ampulla_of_vater:1|bladder:4|prostate:4|soft_tissue:1|breast:1 ENST00000269305 4 single residue 106.0 0.0 0.0 0.0 106.0 1.0 0.0 0.0 0.0 TP53 Y236 Y:59 236 C:40|S:2|D:5|H:2|*:5|N:5 1.29867077765943e-56 1.29867077765943e-56 8.15053158763773e-08 59 bowel:8|skin:3|stomach:1|brain:6|head_neck:7|lung:11|lymph:2|ovary:2|thyroid:1|ampulla_of_vater:1|pancreas:4|bladder:2|prostate:3|soft_tissue:1|breast:7 ENST00000269305 4 single residue 54.0 5.0 0.0 0.0 59.0 0.9152542372881356 0.0847457627118644 0.0 0.0 B2M M1 M:41 1 R:3|T:4|V:9|I:11|K:3|L:11 3.76576315904147e-56 3.76576315904147e-56 5.98567599075945e-15 41 lung:10|lymph:11|ovary:3|uterus:3|pancreas:1|bladder:1|skin:3|bowel:2|stomach:3|head_neck:3|blood:1 ENST00000558401 1 single residue 41.0 0.0 0.0 0.0 41.0 1.0 0.0 0.0 0.0 HRAS G12 G:38 12 A:2|S:14|C:4|D:14|V:3|N:1 4.29398355982767e-56 4.29398355982767e-56 1.74021282845822e-30 38 cervix:1|unk:1|bladder:10|skin:5|soft_tissue:2|head_neck:18|breast:1 ENST00000451590 1 single residue 38.0 0.0 0.0 0.0 38.0 1.0 0.0 0.0 0.0 FGFR3 R248 R:31 248 C:31 2.24097601387903e-52 1.00735050361709e-44 2.24097601387903e-52 31 lung:2|bladder:25|head_neck:2|blood:1|breast:1 ENST00000260795 2 single residue 31.0 0.0 0.0 0.0 31.0 1.0 0.0 0.0 0.0 TP53 C275 C:70 275 R:7|S:6|F:25|W:3|G:2|Y:24|*:3 9.26247541784713e-52 9.26247541784713e-52 1.14503702283721e-07 70 biliary_tract:1|liver:3|adrenal_gland:1|bowel:6|skin:3|stomach:6|brain:8|head_neck:4|blood:2|lung:15|kidney:1|ovary:5|uterus:1|thyroid:1|pancreas:1|bladder:2|prostate:4|soft_tissue:3|breast:3 ENST00000269305 4 single residue 67.0 3.0 0.0 0.0 70.0 0.9571428571428572 0.04285714285714286 0.0 0.0 TP53 C135 C:74 135 R:9|S:4|F:24|W:4|G:2|Y:27|*:4 3.52776955427228e-50 3.52776955427228e-50 5.77717571309906e-15 74 liver:1|bowel:9|stomach:17|brain:2|lung:10|kidney:5|ovary:3|lymph:1|unk:2|thyroid:1|pancreas:4|bladder:3|prostate:5|soft_tissue:2|breast:9 ENST00000269305 4 single residue 70.0 4.0 0.0 0.0 74.0 0.9459459459459459 0.05405405405405406 0.0 0.0 TP53 P278 P:100 278 A:13|R:12|S:37|T:12|F:3|H:6|L:17 5.74722717996462e-50 5.74722717996462e-50 2.6572032144676e-06 100 bowel:10|skin:12|stomach:9|brain:5|head_neck:9|blood:1|lung:18|kidney:1|ovary:8|unk:1|uterus:2|pancreas:5|bladder:7|prostate:4|soft_tissue:1|breast:7 ENST00000269305 4 single residue 100.0 0.0 0.0 0.0 100.0 1.0 0.0 0.0 0.0 IDH2 R140 R:23 140 Q:20|W:2|L:1 1.57907449279138e-48 7.97345435837648e-28 1.57907449279138e-48 23 pancreas:1|bowel:1|stomach:1|blood:19|head_neck:1 ENST00000330062 3 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 SPOP F133 F:67 133 C:8|S:5|V:19|I:3|L:32 9.29184493038497e-48 1.5531129502156e-08 9.29184493038497e-48 67 prostate:67 ENST00000347630 2 single residue 67.0 0.0 0.0 0.0 67.0 1.0 0.0 0.0 0.0 PIK3CA K111 K:38 111 Q:1|R:1|E:22|N:14 3.93686007081858e-47 3.93686007081858e-47 2.15767037975807e-08 38 lung:2|cervix:1|uterus:8|biliary_tract:1|bowel:6|stomach:5|brain:4|breast:8|head_neck:2|blood:1 ENST00000263967 3 single residue 38.0 0.0 0.0 0.0 38.0 1.0 0.0 0.0 0.0 TP53 S241 S:97 241 P:6|A:2|C:19|S:3|T:1|F:51|Y:15 7.17889662377449e-46 7.17889662377449e-46 4.10318250769329e-06 97 cervix:1|biliary_tract:3|skin:8|bowel:9|stomach:5|brain:5|head_neck:2|lung:16|kidney:4|ovary:8|lymph:1|unk:1|uterus:6|thyroid:1|pancreas:5|bladder:10|soft_tissue:3|prostate:2|breast:7 ENST00000269305 4 single residue 97.0 0.0 0.0 0.0 97.0 1.0 0.0 0.0 0.0 EGFR G719 G:33 719 A:18|C:7|S:5|D:3 1.15873816487001e-45 1.18738322628431e-36 1.15873816487001e-45 33 lung:27|bladder:1|stomach:1|brain:3|breast:1 ENST00000275493 2 single residue 33.0 0.0 0.0 0.0 33.0 1.0 0.0 0.0 0.0 TP53 M237 M:64 237 V:4|I:55|K:5 8.54847258220565e-45 8.54847258220565e-45 2.88843439628838e-09 64 bowel:8|stomach:11|brain:9|head_neck:4|lung:12|eye:1|ovary:5|uterus:3|unk:1|pancreas:3|bladder:1|soft_tissue:2|prostate:1|breast:3 ENST00000269305 4 single residue 64.0 0.0 0.0 0.0 64.0 1.0 0.0 0.0 0.0 FGFR2 N549 N:26 549 S:1|T:1|H:3|K:21 2.63567113536069e-44 2.63567113536069e-44 1.38012595895039e-21 26 lung:2|uterus:6|bladder:6|stomach:2|breast:9|head_neck:1 ENST00000358487 5 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 RXRA S427 S:26 427 F:22|Y:4 4.52406657388826e-44 1.3764023024602e-28 4.52406657388826e-44 26 liver:1|pancreas:1|bladder:23|soft_tissue:1 ENST00000481739 1 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 NFE2L2 R34 R:34 34 P:5|Q:11|G:16|*:1|L:1 9.73572135889331e-44 9.73572135889331e-44 2.80260043931907e-17 34 lung:12|kidney:1|cervix:1|uterus:2|thyroid:1|pancreas:1|bladder:8|stomach:1|head_neck:7 ENST00000397062 3 single residue 33.0 1.0 0.0 0.0 34.0 0.9705882352941176 0.029411764705882353 0.0 0.0 TP53 V157 V:77 157 A:1|D:1|F:67|V:1|G:4|L:3 1.04043861763858e-43 1.04043861763858e-43 2.25013578508869e-31 77 lung:36|ovary:9|biliary_tract:1|liver:3|pancreas:4|bladder:3|bowel:3|prostate:2|stomach:1|brain:4|head_neck:6|breast:5 ENST00000269305 4 single residue 77.0 0.0 0.0 0.0 77.0 1.0 0.0 0.0 0.0 MAP2K1 K57 K:29 57 T:7|E:6|N:16 1.73493302101363e-43 1.73493302101363e-43 1.62939584899063e-09 29 lung:7|lymph:4|unk:2|biliary_tract:2|skin:2|bowel:5|prostate:2|stomach:2|brain:1|head_neck:1|breast:1 ENST00000307102 5 single residue 29.0 0.0 0.0 0.0 29.0 1.0 0.0 0.0 0.0 AR L702 L:19 702 H:18|L:1 2.56839664672137e-43 5.23695334489803e-22 2.56839664672137e-43 19 bowel:1|prostate:18 ENST00000374690 3 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 TP53 V272 V:66 272 A:1|E:3|V:1|G:5|K:2|L:20|M:34 9.58986476133168e-43 9.58986476133168e-43 1.48763746882589e-05 66 biliary_tract:1|bowel:6|skin:2|stomach:5|brain:4|head_neck:4|blood:1|lung:12|kidney:2|ovary:7|uterus:1|unk:1|pancreas:8|bladder:2|soft_tissue:1|prostate:2|breast:7 ENST00000269305 4 single residue 66.0 0.0 0.0 0.0 66.0 1.0 0.0 0.0 0.0 FLT3 D835 D:17 835 E:3|V:1|H:2|Y:11 1.02500063276241e-41 8.13293638767938e-12 1.02500063276241e-41 17 blood:17 ENST00000241453 7 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 ATM R337 R:40 337 C:31|H:9 3.53306905480388e-41 3.53306905480388e-41 1.82906034222269e-21 40 bowel:17|skin:4|stomach:2|head_neck:2|lung:3|uterus:2|unk:1|pancreas:2|bladder:2|penis:1|prostate:1|soft_tissue:1|breast:2 ENST00000278616 4 single residue 40.0 0.0 0.0 0.0 40.0 1.0 0.0 0.0 0.0 TP53 K132 K:83 132 Q:2|R:27|T:4|E:14|*:1|M:5|N:30 1.67435535883697e-40 1.67435535883697e-40 3.95169296002549e-10 83 cervix:1|adrenal_gland:1|bowel:7|skin:2|stomach:3|brain:9|head_neck:1|blood:1|lung:17|kidney:1|ovary:7|unk:1|uterus:2|pancreas:7|bladder:8|prostate:3|soft_tissue:3|pleura:1|breast:8 ENST00000269305 4 single residue 82.0 1.0 0.0 0.0 83.0 0.9879518072289156 0.012048192771084338 0.0 0.0 CIC R215 R:25 215 Q:7|R:1|W:17 5.57740350592312e-40 3.6744395540571e-28 5.57740350592312e-40 25 lung:1|bowel:1|skin:1|brain:22 ENST00000575354 2 single residue 25.0 0.0 0.0 0.0 25.0 1.0 0.0 0.0 0.0 PIK3CA E453 E:42 453 Q:10|D:1|K:31 3.19949611689526e-39 3.19949611689526e-39 7.42087794082325e-17 42 lung:3|cervix:1|unk:1|uterus:2|liver:1|bladder:8|bowel:1|stomach:2|brain:6|breast:16|head_neck:1 ENST00000263967 3 single residue 42.0 0.0 0.0 0.0 42.0 1.0 0.0 0.0 0.0 TP53 R280 R:109 280 S:8|T:34|G:17|I:12|*:2|K:36 8.52038865841413e-39 8.52038865841413e-39 7.2668727742144e-20 109 cervix:1|biliary_tract:1|liver:2|skin:5|bowel:2|stomach:4|brain:5|head_neck:9|blood:1|lung:20|ovary:3|unk:2|uterus:3|thyroid:2|pancreas:3|bladder:33|prostate:1|soft_tissue:2|breast:10 ENST00000269305 4 single residue 107.0 2.0 0.0 0.0 109.0 0.981651376146789 0.01834862385321101 0.0 0.0 GTF2I N440 N:19 440 S:19 7.49957559915763e-38 7.49957559915763e-38 4.15303669619865e-23 19 lymph:1|biliary_tract:1|bladder:2|stomach:9|soft_tissue:4|prostate:1|testis:1 ENST00000324896 4 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 NFE2L2 E79 E:34 79 Q:17|D:1|V:2|G:1|*:2|K:11 7.468598929185e-37 7.468598929185e-37 1.57269003966476e-12 34 lung:11|cervix:2|liver:2|bladder:4|stomach:4|brain:1|head_neck:10 ENST00000397062 3 single residue 32.0 2.0 0.0 0.0 34.0 0.9411764705882353 0.058823529411764705 0.0 0.0 ERBB2 R678 R:32 678 Q:31|W:1 9.16633419802267e-37 9.16633419802267e-37 2.78271148737267e-11 32 uterus:4|unk:1|bladder:6|bowel:9|stomach:9|prostate:1|breast:2 ENST00000269571 5 single residue 32.0 0.0 0.0 0.0 32.0 1.0 0.0 0.0 0.0 TP53 S215 S:50 215 R:13|C:1|T:1|G:8|I:20|N:7 1.43787287066506e-36 1.43787287066506e-36 1.09020320153243e-08 50 liver:3|bowel:6|stomach:4|brain:2|blood:1|head_neck:1|lung:14|kidney:1|ovary:2|uterus:2|thyroid:1|pancreas:5|bladder:1|prostate:4|soft_tissue:1|breast:2 ENST00000269305 4 single residue 50.0 0.0 0.0 0.0 50.0 1.0 0.0 0.0 0.0 MET X1010 X:19 1010 sp:19 3.32303024415133e-36 1.61555468221152e-23 3.32303024415133e-36 19 lung:18|brain:1 ENST00000397752 3 splice site 0.0 0.0 0.0 19.0 19.0 0.0 0.0 0.0 1.0 BRAF N581 N:21 581 S:13|T:2|D:1|H:1|I:3|Y:1 3.87360672866837e-36 3.87360672866837e-36 9.43488584806745e-10 21 lung:5|kidney:1|ovary:2|unk:1|bowel:5|skin:5|stomach:1|blood:1 ENST00000288602 6 single residue 21.0 0.0 0.0 0.0 21.0 1.0 0.0 0.0 0.0 KIT N822 N:21 822 Y:6|I:1|K:14 2.30956061262686e-35 2.30956061262686e-35 7.67901429962282e-27 21 unk:1|bowel:2|skin:3|soft_tissue:5|testis:10 ENST00000288135 5 single residue 21.0 0.0 0.0 0.0 21.0 1.0 0.0 0.0 0.0 RHOA G17 G:36 17 A:5|E:15|V:16 4.09456295032167e-35 4.09456295032167e-35 9.40899669694364e-26 36 lymph:14|ovary:1|unk:2|bladder:4|bowel:2|skin:1|stomach:2|breast:10 ENST00000418115 1 single residue 36.0 0.0 0.0 0.0 36.0 1.0 0.0 0.0 0.0 CDK4 R24 R:23 24 C:4|S:2|H:7|L:10 5.35320558359261e-35 5.35320558359261e-35 7.45262241990083e-23 23 lung:10|bladder:1|skin:11|blood:1 ENST00000257904 6 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 BRAF G466 G:34 466 A:3|E:14|V:17 6.72195069896094e-35 6.72195069896094e-35 2.37292518834142e-23 34 lung:17|unk:2|bladder:1|bowel:3|skin:4|prostate:1|brain:1|blood:4|head_neck:1 ENST00000288602 6 single residue 34.0 0.0 0.0 0.0 34.0 1.0 0.0 0.0 0.0 AR T878 T:15 878 A:14|S:1 8.20730580930317e-35 1.41789645635561e-15 8.20730580930317e-35 15 prostate:15 ENST00000374690 3 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 TP53 N239 N:41 239 S:19|D:18|T:1|H:1|K:2 3.83729752034833e-34 3.83729752034833e-34 1.49900808983344e-07 41 liver:1|adrenal_gland:1|bowel:2|stomach:1|brain:1|head_neck:3|lung:7|kidney:3|lymph:2|ovary:1|uterus:7|pancreas:2|bladder:1|prostate:3|breast:6 ENST00000269305 4 single residue 41.0 0.0 0.0 0.0 41.0 1.0 0.0 0.0 0.0 AR H875 H:16 875 Y:16 7.63404370123561e-34 2.4424842058807e-13 7.63404370123561e-34 16 prostate:16 ENST00000374690 3 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 POLE P286 P:27 286 R:23|S:1|T:1|H:1|L:1 1.11888229227845e-33 1.11888229227845e-33 7.76814182426116e-19 27 uterus:11|pancreas:1|bladder:2|bowel:9|prostate:1|stomach:1|breast:2 ENST00000320574 5 single residue 27.0 0.0 0.0 0.0 27.0 1.0 0.0 0.0 0.0 CREBBP R1446 R:33 1446 P:1|C:14|S:1|G:1|H:10|L:6 1.12282141286262e-33 1.12282141286262e-33 0.000136547761615076 33 lung:3|cervix:2|lymph:5|liver:2|bladder:4|skin:2|bowel:4|stomach:3|pleura:1|brain:3|head_neck:4 ENST00000262367 5 single residue 33.0 0.0 0.0 0.0 33.0 1.0 0.0 0.0 0.0 TP53 C242 C:59 242 R:2|S:9|C:1|F:27|W:4|G:3|Y:12|*:1 1.17967885828529e-33 1.17967885828529e-33 8.55755628356135e-09 59 liver:3|bowel:6|stomach:5|brain:2|head_neck:6|blood:2|lung:17|kidney:1|unk:1|uterus:4|pancreas:3|bladder:2|prostate:1|soft_tissue:1|breast:5 ENST00000269305 4 single residue 58.0 1.0 0.0 0.0 59.0 0.9830508474576272 0.01694915254237288 0.0 0.0 CD79B Y197 Y:16 197 R:1|C:2|S:2|D:2|F:2|H:5|N:2 1.2515091895722e-33 8.67081237030029e-20 1.2515091895722e-33 16 lymph:16 ENST00000392795 3 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 NFE2L2 E82 E:21 82 A:3|Q:2|D:13|G:3 4.89627732972955e-33 4.89627732972955e-33 3.65175619206347e-13 21 lung:2|cervix:1|kidney:2|uterus:7|biliary_tract:1|liver:4|bladder:1|bowel:1|stomach:2 ENST00000397062 3 single residue 21.0 0.0 0.0 0.0 21.0 1.0 0.0 0.0 0.0 PIK3CA V344 V:26 344 A:2|G:13|M:11 5.84970496650592e-33 5.84970496650592e-33 5.99859687259964e-09 26 cervix:1|lymph:1|unk:1|uterus:6|bowel:6|skin:2|stomach:1|prostate:1|soft_tissue:1|brain:3|head_neck:1|breast:2 ENST00000263967 3 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 TP53 X261 X:51 261 sp:51 6.79062733955428e-33 6.79062733955428e-33 3.65493607976881e-07 51 liver:1|bowel:4|stomach:6|brain:2|head_neck:4|lung:13|kidney:1|ovary:5|lymph:1|unk:1|uterus:1|pancreas:1|bladder:2|prostate:1|soft_tissue:1|breast:7 ENST00000269305 4 splice site 0.0 0.0 0.0 51.0 51.0 0.0 0.0 0.0 1.0 MED12 G44 G:25 44 A:4|S:8|C:5|D:6|V:2 1.20697083885738e-32 1.20697083885738e-32 1.25483993477165e-11 25 lymph:1|biliary_tract:2|uterus:8|bladder:2|bowel:4|soft_tissue:2|prostate:1|brain:2|blood:1|breast:2 ENST00000374080 3 single residue 25.0 0.0 0.0 0.0 25.0 1.0 0.0 0.0 0.0 EGFR L861 L:21 861 Q:21 7.90212878554118e-32 4.85937721144745e-22 7.90212878554118e-32 21 lung:19|bowel:2 ENST00000275493 2 single residue 21.0 0.0 0.0 0.0 21.0 1.0 0.0 0.0 0.0 ERBB4 S1289 S:12 1289 A:12 8.08817732031978e-32 1.4307558937425e-14 8.08817732031978e-32 12 bladder:12 ENST00000342788 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 G244 G:65 244 A:1|R:1|C:19|S:15|D:21|V:6|F:1|G:1 1.00026964688445e-31 1.00026964688445e-31 2.82254694740263e-06 65 cervix:1|biliary_tract:1|liver:1|bowel:5|stomach:7|brain:8|head_neck:2|lung:17|kidney:1|ovary:7|lymph:3|uterus:3|unk:1|pancreas:1|bladder:3|soft_tissue:2|breast:2 ENST00000269305 4 single residue 65.0 0.0 0.0 0.0 65.0 1.0 0.0 0.0 0.0 PIK3CA R93 R:31 93 Q:18|W:12|L:1 1.87724928790338e-31 1.87724928790338e-31 1.83577956820323e-11 31 lung:1|cervix:2|uterus:11|bladder:3|bowel:4|stomach:5|brain:2|breast:3 ENST00000263967 3 single residue 31.0 0.0 0.0 0.0 31.0 1.0 0.0 0.0 0.0 MED12 L1224 L:18 1224 F:16|V:2 1.98093425904712e-31 1.46235441005534e-16 1.98093425904712e-31 18 lung:1|pancreas:1|prostate:14|stomach:1|breast:1 ENST00000374080 3 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 ERCC2 N238 N:16 238 S:16 2.0595128011563e-31 3.77405884109069e-27 2.0595128011563e-31 16 kidney:1|bladder:14|breast:1 ENST00000391945 4 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 FOXL2 C134 C:12 134 W:12 4.37607216698428e-31 4.75828697365587e-11 4.37607216698428e-31 12 ovary:12 ENST00000330315 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 STK19 D89 D:18 89 D:2|N:16 7.07803453190923e-31 2.58459789737952e-21 7.07803453190923e-31 18 skin:18 ENST00000375331 2 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 TP53 V274 V:46 274 A:12|D:7|F:14|G:8|L:5 9.09067281233547e-31 9.09067281233547e-31 2.53614610695731e-06 46 lung:11|ovary:2|uterus:1|liver:3|pancreas:4|bladder:2|bowel:4|skin:1|prostate:3|stomach:4|brain:3|breast:8 ENST00000269305 4 single residue 46.0 0.0 0.0 0.0 46.0 1.0 0.0 0.0 0.0 PIK3CA R108 R:29 108 S:1|H:25|L:3 2.1807379100544e-30 2.1807379100544e-30 5.16287874819688e-07 29 biliary_tract:2|bowel:8|skin:1|bone:1|stomach:1|brain:1|lung:3|lymph:2|ovary:1|uterus:6|bladder:1|prostate:1|breast:1 ENST00000263967 3 single residue 29.0 0.0 0.0 0.0 29.0 1.0 0.0 0.0 0.0 MAPK1 E322 E:26 322 A:1|*:1|K:24 2.78211627645888e-30 2.78211627645888e-30 1.07105464000144e-26 26 lung:1|cervix:7|lymph:1|bladder:4|skin:1|head_neck:12 ENST00000215832 6 single residue 25.0 1.0 0.0 0.0 26.0 0.9615384615384616 0.038461538461538464 0.0 0.0 XPO1 E571 E:27 571 A:1|V:1|K:25 3.18647292377788e-30 3.18647292377788e-30 8.24178512813082e-16 27 lymph:7|uterus:3|bladder:1|bowel:3|prostate:2|blood:7|breast:4 ENST00000401558 2 single residue 27.0 0.0 0.0 0.0 27.0 1.0 0.0 0.0 0.0 RHOA Y42 Y:19 42 C:14|S:3|F:1|I:1 8.6265832611386e-30 2.53147032890188e-26 8.6265832611386e-30 19 lymph:1|ampulla_of_vater:1|stomach:16|head_neck:1 ENST00000418115 1 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 NFE2L2 D29 D:30 29 G:2|H:19|Y:7|N:2 1.19589215959561e-29 1.19589215959561e-29 1.70501807491261e-11 30 lung:10|cervix:3|kidney:3|uterus:1|bladder:5|bowel:1|stomach:1|head_neck:6 ENST00000397062 3 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 ERBB2 V777 V:20 777 L:17|M:3 2.19804285674572e-29 2.19804285674572e-29 1.59950039988311e-09 20 ampulla_of_vater:1|bladder:2|bowel:5|stomach:5|breast:6|head_neck:1 ENST00000269571 5 single residue 20.0 0.0 0.0 0.0 20.0 1.0 0.0 0.0 0.0 TP53 X331 X:49 331 sp:49 4.86590998582027e-29 4.86590998582027e-29 3.92357375840703e-07 49 biliary_tract:1|liver:1|bowel:9|skin:1|head_neck:2|blood:1|lung:8|ovary:7|lymph:1|unk:1|pancreas:3|bladder:3|prostate:1|soft_tissue:1|breast:9 ENST00000269305 4 splice site 0.0 0.0 0.0 49.0 49.0 0.0 0.0 0.0 1.0 KIT D816 D:22 816 A:1|V:11|H:5|Y:5 1.55789397481015e-28 3.28966975451357e-26 1.55789397481015e-28 22 unk:4|testis:13|blood:5 ENST00000288135 5 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 KRAS G60 G:24 60 S:1|D:2|V:2|G:19 2.36547550250116e-28 2.36547550250116e-28 5.29647466576282e-10 24 lung:1|biliary_tract:1|unk:2|thyroid:2|pancreas:2|bladder:2|bowel:9|skin:2|stomach:2|blood:1 ENST00000311936 3 single residue 24.0 0.0 0.0 0.0 24.0 1.0 0.0 0.0 0.0 ALK R1275 R:18 1275 Q:16|*:1|L:1 6.65371720051819e-28 5.62890180980892e-12 6.65371720051819e-28 18 bowel:1|prostate:1|brain:15|breast:1 ENST00000389048 3 single residue 17.0 1.0 0.0 0.0 18.0 0.9444444444444444 0.05555555555555555 0.0 0.0 CTNNB1 K335 K:19 335 T:3|I:16 1.26036406875161e-27 1.26036406875161e-27 1.39138929152303e-21 19 biliary_tract:1|liver:11|bowel:3|skin:1|prostate:1|stomach:1|penis:1 ENST00000349496 5 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 ALK F1174 F:14 1174 C:2|V:1|L:11 1.9674160903607e-27 3.0610572581767e-13 1.9674160903607e-27 14 lung:1|kidney:1|brain:12 ENST00000389048 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 ERBB2 V842 V:26 842 I:26 2.90199531502456e-27 2.90199531502456e-27 5.035772927258e-10 26 uterus:7|biliary_tract:1|pancreas:3|bladder:2|bowel:8|stomach:3|prostate:1|breast:1 ENST00000269571 5 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 MAP2K1 P124 P:25 124 P:1|Q:1|R:1|S:15|L:6|M:1 5.99241948540617e-27 1.15332266448994e-19 5.99241948540617e-27 25 unk:2|uterus:1|bladder:1|skin:20|bowel:1 ENST00000307102 5 single residue 25.0 0.0 0.0 0.0 25.0 1.0 0.0 0.0 0.0 SMAD4 D537 D:30 537 A:1|E:4|V:5|G:10|H:6|Y:4 6.16661226103394e-27 6.16661226103394e-27 3.52757554269938e-20 30 lung:3|ovary:1|pancreas:5|bowel:19|stomach:2 ENST00000342988 3 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 TP53 E285 E:99 285 Q:3|E:4|V:9|*:15|K:68 1.42429549670277e-26 1.42429549670277e-26 1.21708096814487e-19 99 cervix:2|biliary_tract:3|adrenal_gland:1|skin:6|bowel:5|stomach:8|bone:1|head_neck:5|lung:15|lymph:1|unk:4|uterus:1|thyroid:1|bladder:33|prostate:2|pleura:1|breast:10 ENST00000269305 4 single residue 84.0 15.0 0.0 0.0 99.0 0.8484848484848485 0.15151515151515152 0.0 0.0 TP53 H214 H:40 214 P:1|Q:2|R:35|L:2 3.13070819109956e-26 3.13070819109956e-26 9.31629704822771e-06 40 liver:2|bowel:2|stomach:4|brain:3|blood:1|lung:10|kidney:1|ovary:2|lymph:1|uterus:1|thyroid:2|pancreas:6|bladder:3|soft_tissue:2 ENST00000269305 4 single residue 40.0 0.0 0.0 0.0 40.0 1.0 0.0 0.0 0.0 SMARCA4 T910 T:29 910 A:1|R:1|T:1|M:26 3.37629225284153e-26 3.37629225284153e-26 6.59938452140108e-05 29 thymus:1|bowel:2|stomach:6|bone:2|brain:5|lung:2|eye:1|kidney:1|unk:1|uterus:2|pancreas:3|bladder:1|prostate:1|breast:1 ENST00000358026 2 single residue 29.0 0.0 0.0 0.0 29.0 1.0 0.0 0.0 0.0 PIK3CA G106 G:22 106 R:6|C:1|S:1|V:14 6.87260103192609e-26 6.87260103192609e-26 0.000146066010043822 22 lung:2|cervix:1|kidney:1|uterus:4|bladder:4|bowel:2|skin:1|prostate:2|brain:3|breast:2 ENST00000263967 3 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 H3C2 K28 K:12 28 E:1|M:11 1.52283836674349e-25 1.37370960803098e-10 1.52283836674349e-25 12 brain:11|head_neck:1 ENST00000244661 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 POLE V411 V:18 411 L:18 2.55791309710685e-25 2.55791309710685e-25 7.69674796797864e-21 18 uterus:10|unk:1|bowel:4|stomach:1|penis:1|brain:1 ENST00000320574 5 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 FGFR1 N577 N:19 577 D:2|K:17 5.27840065160741e-25 5.27840065160741e-25 1.54524617309519e-23 19 cervix:1|adrenal_gland:2|soft_tissue:3|stomach:1|brain:11|breast:1 ENST00000425967 3 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 TP53 E286 E:73 286 Q:7|A:2|V:3|G:6|*:14|K:41 7.08380811769577e-25 7.08380811769577e-25 0.00359601525700161 73 biliary_tract:1|liver:2|skin:10|bowel:5|stomach:6|brain:3|head_neck:4|blood:1|lung:12|lymph:2|ovary:1|unk:1|uterus:1|pancreas:4|bladder:6|soft_tissue:4|prostate:1|breast:9 ENST00000269305 4 single residue 59.0 14.0 0.0 0.0 73.0 0.8082191780821918 0.1917808219178082 0.0 0.0 RAF1 S257 S:25 257 W:1|L:24 3.23332678171542e-24 3.23332678171542e-24 2.62318344226892e-12 25 lung:5|unk:1|bladder:1|bowel:11|skin:3|stomach:3|vulva:1 ENST00000251849 4 single residue 25.0 0.0 0.0 0.0 25.0 1.0 0.0 0.0 0.0 FGFR2 S252 S:22 252 S:2|W:18|L:2 4.17409859833416e-24 1.41585243787505e-13 4.17409859833416e-24 22 ovary:1|uterus:16|unk:1|bladder:1|stomach:2|breast:1 ENST00000358487 5 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 KRAS K117 K:18 117 R:1|N:17 5.40950832194339e-24 5.40950832194339e-24 2.95723395807931e-13 18 unk:1|liver:1|bowel:9|skin:1|stomach:2|soft_tissue:1|blood:3 ENST00000311936 3 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 EGFR R108 R:19 108 G:2|K:17 5.53217157202984e-24 1.35369413463073e-12 5.53217157202984e-24 19 stomach:1|brain:18 ENST00000275493 2 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 PIK3R1 N564 N:17 564 D:17 1.08334499567202e-23 1.08334499567202e-23 2.03199170844153e-09 17 lung:1|uterus:2|bowel:5|skin:1|stomach:1|soft_tissue:1|brain:6 ENST00000274335 5 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 NFE2L2 G31 G:21 31 A:9|R:4|E:7|V:1 2.43250010760161e-23 2.43250010760161e-23 7.77482555555749e-08 21 lung:8|uterus:1|liver:1|bladder:2|bowel:1|stomach:4|head_neck:2|breast:2 ENST00000397062 3 single residue 21.0 0.0 0.0 0.0 21.0 1.0 0.0 0.0 0.0 NFE2L2 G81 G:19 81 A:1|R:3|S:6|C:2|D:3|V:4 2.60359287698573e-23 2.60359287698573e-23 0.000408221207383044 19 lung:5|kidney:4|uterus:2|liver:2|bladder:1|stomach:3|breast:1|head_neck:1 ENST00000397062 3 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 ELOC Y79 Y:10 79 C:6|S:1|F:1|*:1|N:1 2.66761546087334e-23 2.53061381579063e-11 2.66761546087334e-23 10 kidney:10 ENST00000284811 8 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 MAP2K1 F53 F:17 53 C:2|V:2|I:1|L:12 7.28455410553735e-23 7.28455410553735e-23 0.000845933613567008 17 lung:2|kidney:1|lymph:1|thymus:1|bladder:3|bowel:3|skin:1|stomach:3|soft_tissue:1|blood:1 ENST00000307102 5 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 ERBB3 E928 E:17 928 G:15|K:2 8.04884338962201e-23 8.04884338962201e-23 2.58403421979703e-16 17 lung:1|kidney:1|biliary_tract:1|uterus:1|bladder:2|bowel:2|stomach:1|breast:8 ENST00000267101 3 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 ERBB3 D297 D:22 297 A:1|V:1|H:1|Y:18|N:1 8.04884338962201e-23 8.04884338962201e-23 3.62663569626713e-05 22 lung:1|uterus:4|biliary_tract:1|bladder:6|bowel:2|stomach:5|breast:3 ENST00000267101 3 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 TP53 X225 X:46 225 sp:46 9.76065282760022e-23 9.76065282760022e-23 2.03069644000318e-06 46 liver:1|skin:3|bowel:2|stomach:3|brain:3|head_neck:5|blood:1|lung:10|kidney:3|ovary:3|uterus:3|unk:1|prostate:1|breast:7 ENST00000269305 4 splice site 0.0 0.0 0.0 46.0 46.0 0.0 0.0 0.0 1.0 TP53 C141 C:47 141 R:5|S:1|F:1|W:9|G:4|Y:25|*:2 1.81124424263192e-22 1.81124424263192e-22 5.20772247497556e-06 47 biliary_tract:2|liver:1|bowel:5|stomach:2|brain:3|blood:2|head_neck:2|lung:4|kidney:1|ovary:2|uterus:3|pancreas:4|bladder:2|prostate:4|soft_tissue:1|breast:9 ENST00000269305 4 single residue 45.0 2.0 0.0 0.0 47.0 0.9574468085106383 0.0425531914893617 0.0 0.0 TP53 D281 D:69 281 P:1|A:1|D:4|E:14|V:9|G:4|H:9|Y:13|N:14 3.56196704807636e-22 3.56196704807636e-22 1.56686137927263e-06 69 biliary_tract:1|liver:1|skin:5|bowel:1|bone:1|stomach:1|brain:10|blood:2|head_neck:1|lung:16|kidney:2|ovary:4|uterus:5|unk:1|pancreas:3|bladder:6|soft_tissue:2|breast:7 ENST00000269305 4 single residue 69.0 0.0 0.0 0.0 69.0 1.0 0.0 0.0 0.0 EP300 D1399 D:23 1399 E:1|Y:2|N:20 6.88350174669892e-22 6.88350174669892e-22 1.87394605677182e-07 23 lung:3|cervix:5|lymph:1|uterus:1|bladder:2|bowel:1|stomach:3|brain:1|head_neck:6 ENST00000263253 7 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 TP53 V216 V:42 216 E:4|G:5|L:9|M:24 7.05793465485541e-22 7.05793465485541e-22 0.0105977882452641 42 biliary_tract:1|liver:1|bowel:1|skin:2|stomach:2|brain:5|head_neck:2|lung:7|ovary:4|lymph:2|uterus:2|pancreas:3|soft_tissue:1|prostate:3|breast:6 ENST00000269305 4 single residue 42.0 0.0 0.0 0.0 42.0 1.0 0.0 0.0 0.0 SMAD4 G386 G:22 386 A:1|R:2|S:3|C:1|D:9|V:6 8.21942263343406e-22 8.21942263343406e-22 1.10155907417214e-10 22 lung:1|pancreas:5|bowel:6|stomach:8|prostate:1|breast:1 ENST00000342988 3 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 TP53 X125 X:43 125 sp:43 8.50379958533421e-22 8.50379958533421e-22 0.000147761463595833 43 biliary_tract:1|adrenal_gland:1|skin:4|bowel:1|stomach:7|bone:1|brain:4|head_neck:4|vulva:1|lung:7|ovary:2|unk:1|uterus:1|pancreas:2|soft_tissue:2|breast:4 ENST00000269305 4 splice site 0.0 0.0 0.0 43.0 43.0 0.0 0.0 0.0 1.0 TP53 R337 R:68 337 P:3|C:36|S:4|G:1|H:4|L:20 8.69771954614254e-22 8.69771954614254e-22 7.31219407835892e-08 68 cervix:1|biliary_tract:1|liver:2|adrenal_gland:3|bowel:11|skin:1|stomach:3|brain:2|head_neck:5|blood:1|lung:17|kidney:2|ovary:1|unk:3|uterus:2|pancreas:3|bladder:1|prostate:2|soft_tissue:1|breast:6 ENST00000269305 4 single residue 68.0 0.0 0.0 0.0 68.0 1.0 0.0 0.0 0.0 EGFR S768 S:15 768 T:1|I:14 1.19234002187539e-21 2.59976440226842e-13 1.19234002187539e-21 15 lung:14|bowel:1 ENST00000275493 2 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 EIF1AX X113 X:11 113 sp:11 1.63796513654497e-21 4.03187925070073e-09 1.63796513654497e-21 11 thyroid:11 ENST00000379607 5 splice site 0.0 0.0 0.0 11.0 11.0 0.0 0.0 0.0 1.0 PTPN11 A72 A:18 72 S:1|T:6|D:3|V:6|G:2 3.59179236148491e-21 4.19391135508506e-17 3.59179236148491e-21 18 brain:14|blood:3|breast:1 ENST00000351677 2 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 MYCN P44 P:20 44 F:1|L:19 7.3609248682335e-21 7.3609248682335e-21 1.35690697520731e-14 20 uterus:4|pancreas:3|skin:4|brain:8|head_neck:1 ENST00000281043 3 single residue 20.0 0.0 0.0 0.0 20.0 1.0 0.0 0.0 0.0 SDHAF2 X87 X:9 87 sp:9 7.98189363303711e-21 8.48157473181256e-08 7.98189363303711e-21 9 kidney:9 ENST00000301761 2 splice site 0.0 0.0 0.0 9.0 9.0 0.0 0.0 0.0 1.0 PDGFRA D842 D:12 842 D:1|V:9|H:1|I:1 1.11042381548794e-20 4.55446015909826e-10 1.11042381548794e-20 12 lung:1|soft_tissue:8|brain:3 ENST00000257290 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 Y126 Y:33 126 C:11|S:3|D:8|H:2|*:7|N:2 1.53812159511432e-20 1.53812159511432e-20 0.000386456765704427 33 lung:3|lymph:1|liver:2|pancreas:5|bowel:4|stomach:4|soft_tissue:1|prostate:3|brain:1|breast:5|head_neck:4 ENST00000269305 4 single residue 26.0 7.0 0.0 0.0 33.0 0.7878787878787878 0.21212121212121213 0.0 0.0 NFE2L2 T80 T:15 80 P:2|A:3|R:5|I:1|K:4 2.59468886654441e-20 2.59468886654441e-20 0.00163557660297717 15 lung:3|kidney:2|ovary:1|uterus:3|thyroid:1|liver:1|bladder:2|stomach:1|head_neck:1 ENST00000397062 3 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 PIK3CA G1049 G:17 1049 A:1|R:16 2.7633032404138e-20 2.7633032404138e-20 4.13636797679232e-09 17 lung:1|kidney:1|ovary:1|uterus:3|bladder:1|bowel:3|breast:7 ENST00000263967 3 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 ESR1 L536 L:14 536 P:3|Q:1|R:2|H:6|L:2 2.9652701136616e-20 7.69683343530031e-12 2.9652701136616e-20 14 uterus:2|breast:12 ENST00000206249 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 SF3B1 E902 E:17 902 Q:3|G:1|K:13 3.68985777208901e-20 5.55598692799606e-08 3.68985777208901e-20 17 bladder:15|skin:2 ENST00000335508 6 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 TP53 A159 A:52 159 P:23|A:1|D:1|V:27 4.57178660230022e-20 4.57178660230022e-20 2.64635417636361e-10 52 liver:1|skin:4|bowel:4|stomach:1|bone:1|brain:3|head_neck:3|blood:1|lung:20|kidney:1|ovary:2|pancreas:2|bladder:5|prostate:2|breast:2 ENST00000269305 4 single residue 52.0 0.0 0.0 0.0 52.0 1.0 0.0 0.0 0.0 TP53 I255 I:32 255 S:6|T:6|F:12|I:1|N:7 6.05480414387033e-20 6.05480414387033e-20 0.000117174895041775 32 biliary_tract:1|liver:1|bowel:3|stomach:3|brain:3|blood:1|head_neck:2|lung:3|ovary:1|uterus:2|pancreas:3|prostate:3|breast:6 ENST00000269305 4 single residue 32.0 0.0 0.0 0.0 32.0 1.0 0.0 0.0 0.0 PPP6C R264 R:19 264 C:19 1.18595587087755e-19 5.71943732954774e-13 1.18595587087755e-19 19 lung:1|unk:1|skin:17 ENST00000373547 4 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 PIK3CA Y1021 Y:14 1021 C:11|H:3 1.32809167941191e-19 1.32809167941191e-19 7.07683388347835e-05 14 uterus:4|bowel:4|skin:1|stomach:2|prostate:1|breast:2 ENST00000263967 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 KIT K642 K:14 642 Q:1|E:12|N:1 1.33539003985944e-19 1.33539003985944e-19 7.85705721972859e-18 14 skin:8|bowel:1|soft_tissue:2|stomach:1|testis:2 ENST00000288135 5 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 TP53 L194 L:49 194 P:3|R:30|F:12|H:4 1.50602327108872e-19 1.50602327108872e-19 4.3116838458423e-08 49 cervix:1|thymus:1|liver:1|adrenal_gland:1|bowel:3|skin:1|stomach:2|brain:2|head_neck:3|lung:11|ovary:3|lymph:1|pancreas:5|bladder:4|soft_tissue:1|breast:9 ENST00000269305 4 single residue 49.0 0.0 0.0 0.0 49.0 1.0 0.0 0.0 0.0 PIK3R1 G376 G:18 376 R:18 1.67548192695841e-19 1.39372397107581e-17 1.67548192695841e-19 18 lung:1|uterus:1|bowel:1|skin:1|stomach:2|brain:12 ENST00000274335 5 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 TP53 X224 X:39 224 sp:39 2.23757783098521e-19 2.23757783098521e-19 0.00172630283123666 39 liver:2|bowel:3|skin:1|stomach:6|brain:1|head_neck:5|blood:1|lung:8|kidney:1|ovary:3|unk:1|thyroid:1|pancreas:2|soft_tissue:2|prostate:1|breast:1 ENST00000269305 4 splice site 0.0 0.0 0.0 39.0 39.0 0.0 0.0 0.0 1.0 PIK3CA R38 R:22 38 C:8|S:1|G:1|H:11|L:1 3.16459873021845e-19 3.16459873021845e-19 1.91196284897191e-06 22 lung:1|cervix:1|uterus:7|bowel:7|stomach:2|prostate:1|brain:3 ENST00000263967 3 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 MET D1010 D:14 1010 H:6|Y:2|N:6 3.42669514641377e-19 4.21610152769422e-10 3.42669514641377e-19 14 lung:13|unk:1 ENST00000397752 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 SPOP F102 F:24 102 C:12|S:2|V:7|I:1|L:2 1.62286422111738e-18 0.0512458830813128 1.62286422111738e-18 24 lymph:1|bladder:1|prostate:22 ENST00000347630 2 single residue 24.0 0.0 0.0 0.0 24.0 1.0 0.0 0.0 0.0 PIK3CA N1044 N:14 1044 Y:2|K:12 1.63185954246621e-18 1.63185954246621e-18 6.78663034195231e-07 14 kidney:2|unk:2|uterus:2|prostate:2|brain:1|breast:5 ENST00000263967 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 MAX R60 R:23 60 Q:21|R:1|W:1 1.63574150622726e-18 1.63574150622726e-18 2.61415259357158e-07 23 lung:2|uterus:3|unk:1|pancreas:1|bowel:6|skin:2|stomach:1|brain:6|blood:1 ENST00000358664 4 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 PPP2R1A S256 S:14 256 F:11|Y:3 3.21769293190453e-18 1.91418674998917e-12 3.21769293190453e-18 14 ovary:1|uterus:11|bladder:1|breast:1 ENST00000322088 6 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 PIK3CA E81 E:25 81 *:1|K:24 4.01643559943444e-18 4.01643559943444e-18 0.000269895508444541 25 lung:2|cervix:1|kidney:1|uterus:4|thyroid:1|bowel:4|skin:1|brain:2|breast:7|head_neck:2 ENST00000263967 3 single residue 24.0 1.0 0.0 0.0 25.0 0.96 0.04 0.0 0.0 FGFR2 C382 C:15 382 R:14|Y:1 4.7730084036351e-18 4.7730084036351e-18 1.72695224148736e-13 15 cervix:1|uterus:7|biliary_tract:2|skin:1|stomach:3|testis:1 ENST00000358487 5 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 CDKN2A P114 P:31 114 P:2|S:1|T:2|F:1|H:1|L:24 6.37256811718714e-18 6.37256811718714e-18 1.57933825577359e-16 31 lung:2|unk:3|pancreas:1|bladder:1|skin:20|head_neck:4 ENST00000579755 1 single residue 31.0 0.0 0.0 0.0 31.0 1.0 0.0 0.0 0.0 ESR1 E380 E:14 380 Q:14 2.06583810918944e-17 0.000215437529890256 2.06583810918944e-17 14 breast:14 ENST00000206249 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 SMAD4 D351 D:20 351 A:1|V:2|G:3|H:3|Y:6|N:5 2.31112791341444e-17 2.31112791341444e-17 0.000655570941686095 20 lung:6|biliary_tract:1|pancreas:3|bowel:5|stomach:4|prostate:1 ENST00000342988 3 single residue 20.0 0.0 0.0 0.0 20.0 1.0 0.0 0.0 0.0 ERBB3 K329 K:12 329 R:1|T:2|E:9 3.29864591429092e-17 3.29864591429092e-17 2.38741816821743e-06 12 uterus:1|bladder:4|bowel:2|stomach:1|breast:3|head_neck:1 ENST00000267101 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 PIK3R1 K567 K:12 567 E:12 3.34660265701711e-17 3.34660265701711e-17 1.96184283340875e-05 12 lymph:1|uterus:4|bowel:4|stomach:2|brain:1 ENST00000274335 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 CDKN2A D108 D:29 108 V:1|G:1|H:4|Y:14|N:9 5.41040232412513e-17 5.41040232412513e-17 4.02702065266893e-08 29 lung:10|ovary:1|biliary_tract:1|bladder:12|head_neck:4|breast:1 ENST00000579755 1 single residue 29.0 0.0 0.0 0.0 29.0 1.0 0.0 0.0 0.0 KIT V559 V:14 559 A:6|D:5|G:3 5.59843123930108e-17 5.59843123930108e-17 6.5206407850421e-15 14 thymus:1|skin:3|bowel:1|soft_tissue:8|breast:1 ENST00000288135 5 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 CDKN2A D84 D:26 84 A:1|D:1|V:3|G:3|Y:6|N:12 6.27026193952657e-17 6.27026193952657e-17 0.000476358824183338 26 lung:7|biliary_tract:2|unk:1|pancreas:2|bladder:4|skin:1|stomach:5|brain:1|head_neck:2|breast:1 ENST00000579755 1 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 MTOR S2215 S:22 2215 T:1|F:9|Y:12 1.24086584913819e-16 1.24086584913819e-16 0.000499775980162943 22 lung:3|kidney:4|cervix:2|uterus:4|bowel:5|skin:2|brain:1|head_neck:1 ENST00000361445 4 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 TGFBR2 R553 R:23 553 C:9|G:1|H:10|L:3 1.73780438735199e-16 1.73780438735199e-16 1.89474600027621e-14 23 lung:1|unk:1|pancreas:3|bowel:13|skin:1|stomach:1|breast:1|head_neck:2 ENST00000295754 5 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 RHEB Y35 Y:12 35 C:2|S:2|H:2|*:1|N:5 4.97821246870288e-16 4.97821246870288e-16 1.78232893975983e-05 12 kidney:4|uterus:3|pancreas:1|bladder:1|bowel:1|testis:2 ENST00000262187 5 single residue 11.0 1.0 0.0 0.0 12.0 0.9166666666666666 0.08333333333333333 0.0 0.0 TP53 X33 X:35 33 sp:35 5.09683349058292e-16 5.09683349058292e-16 6.18058007958518e-05 35 liver:4|bowel:7|skin:1|stomach:2|head_neck:3|lung:5|kidney:3|ovary:2|unk:1|uterus:1|pancreas:2|bladder:1|prostate:1|soft_tissue:1|breast:1 ENST00000269305 4 splice site 0.0 0.0 0.0 35.0 35.0 0.0 0.0 0.0 1.0 KIT L576 L:14 576 P:14 6.10110567747655e-16 6.10110567747655e-16 1.03858295452953e-09 14 skin:4|soft_tissue:6|testis:2|head_neck:1|vulva:1 ENST00000288135 5 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 KIT V654 V:8 654 A:8 6.35339710250059e-16 3.58130562901724e-08 6.35339710250059e-16 8 soft_tissue:8 ENST00000288135 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 MTOR T1977 T:14 1977 R:3|S:1|I:3|K:7 7.60484276660308e-16 7.60484276660308e-16 1.91457399475265e-08 14 lung:1|kidney:6|unk:1|uterus:1|bladder:1|bowel:2|prostate:1|blood:1 ENST00000361445 4 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 TP53 F270 F:30 270 S:6|C:4|V:8|I:4|L:8 1.26152260238551e-15 1.26152260238551e-15 6.98672971063527e-07 30 lung:7|ovary:2|pancreas:1|bladder:1|bowel:1|skin:1|stomach:4|soft_tissue:1|prostate:1|brain:2|breast:8|head_neck:1 ENST00000269305 4 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 H3-3A G35 G:12 35 R:9|V:2|W:1 1.61532856518637e-15 1.10916394563316e-08 1.61532856518637e-15 12 adrenal_gland:1|soft_tissue:1|brain:10 ENST00000366813 1 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RRAS2 Q72 Q:9 72 H:2|L:7 6.59079770930105e-15 6.59079770930105e-15 8.4377272208164e-07 9 lung:3|uterus:4|prostate:1|head_neck:1 ENST00000256196 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 PTEN R173 R:32 173 P:1|C:14|H:17 1.02111146115902e-14 1.02111146115902e-14 0.00124856963147957 32 lung:1|lymph:1|ovary:1|uterus:6|biliary_tract:1|bladder:1|bowel:8|skin:1|prostate:2|soft_tissue:1|brain:8|head_neck:1 ENST00000371953 3 single residue 32.0 0.0 0.0 0.0 32.0 1.0 0.0 0.0 0.0 CREBBP Y1503 Y:9 1503 C:1|S:1|D:1|H:4|N:2 1.40143294855795e-14 9.21848191194662e-07 1.40143294855795e-14 9 lymph:8|bladder:1 ENST00000262367 5 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 TP53 E258 E:47 258 A:4|Q:4|D:5|E:1|V:1|G:4|*:14|K:14 1.50604967554599e-14 1.50604967554599e-14 0.00119350839575206 47 liver:2|bowel:5|skin:2|stomach:2|brain:2|head_neck:2|lung:11|ovary:1|unk:1|pancreas:7|bladder:6|prostate:2|breast:4 ENST00000269305 4 single residue 33.0 14.0 0.0 0.0 47.0 0.7021276595744681 0.2978723404255319 0.0 0.0 PIK3CA C901 C:13 901 F:13 1.63044244852762e-14 1.63044244852762e-14 0.000123329023596293 13 uterus:4|biliary_tract:1|bowel:1|bone:1|prostate:1|brain:2|breast:2|head_neck:1 ENST00000263967 3 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 GATA3 M293 M:9 293 R:1|K:8 1.77835401903853e-14 1.13224511004486e-06 1.77835401903853e-14 9 breast:9 ENST00000346208 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 CTNNB1 N387 N:11 387 I:1|Y:1|K:9 2.74228910619457e-14 2.74228910619457e-14 6.54192435821029e-05 11 lung:1|unk:1|liver:4|pancreas:2|bowel:1|skin:1|prostate:1 ENST00000349496 5 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ERBB4 Q707 Q:11 707 Q:5|E:6 2.78828635378649e-14 1 2.78828635378649e-14 11 bladder:11 ENST00000342788 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 RET M918 M:11 918 T:11 3.89383943076572e-14 4.82490299242993e-10 3.89383943076572e-14 11 thyroid:6|adrenal_gland:4|breast:1 ENST00000355710 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 CIC R202 R:13 202 Q:2|W:11 8.48771778696607e-14 3.26869476264658e-08 8.48771778696607e-14 13 prostate:1|soft_tissue:1|brain:11 ENST00000575354 2 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 CDKN2A Q50 Q:23 50 R:3|H:4|*:16 9.45718518403517e-14 9.45718518403517e-14 6.89837202737146e-10 23 lung:2|pancreas:4|skin:13|stomach:3|head_neck:1 ENST00000579755 1 single residue 7.0 16.0 0.0 0.0 23.0 0.30434782608695654 0.6956521739130435 0.0 0.0 FOXA1 F266 F:11 266 C:2|S:1|F:1|V:1|I:1|L:5 1.05845615051602e-13 9.11937320865307e-08 1.05845615051602e-13 11 prostate:9|breast:2 ENST00000250448 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ERBB3 A232 A:15 232 T:1|V:14 1.11785460538783e-13 1.11785460538783e-13 0.000169986861961844 15 lung:1|biliary_tract:1|unk:1|pancreas:1|bowel:5|stomach:3|prostate:1|breast:1|head_neck:1 ENST00000267101 3 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 RB1 X405 X:19 405 sp:19 1.54376720926398e-13 1.54376720926398e-13 1.35926495429174e-05 19 lung:5|ovary:1|uterus:1|bladder:6|prostate:2|soft_tissue:1|brain:3 ENST00000267163 4 splice site 0.0 0.0 0.0 19.0 19.0 0.0 0.0 0.0 1.0 SPOP W131 W:23 131 R:1|C:4|S:3|G:12|L:3 1.9688757329735e-13 0.0701121988722386 1.9688757329735e-13 23 uterus:1|prostate:21|brain:1 ENST00000347630 2 single residue 23.0 0.0 0.0 0.0 23.0 1.0 0.0 0.0 0.0 SPOP Y87 Y:14 87 S:3|C:2|D:1|N:8 1.9688757329735e-13 0.000473866085235921 1.9688757329735e-13 14 prostate:14 ENST00000347630 2 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 MTOR I2500 I:10 2500 F:5|M:4|N:1 2.29333311583453e-13 2.29333311583453e-13 0.309458107060255 10 lung:1|kidney:2|unk:1|uterus:1|adrenal_gland:1|skin:1|stomach:1|breast:1|head_neck:1 ENST00000361445 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 SMARCB1 R377 R:17 377 C:5|H:11|L:1 2.32553910162698e-13 2.32553910162698e-13 0.0438715158585035 17 lung:2|kidney:1|biliary_tract:1|liver:1|bowel:3|skin:1|stomach:4|soft_tissue:1|brain:2|breast:1 ENST00000263121 7 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 PIK3CB D1067 D:13 1067 A:1|V:8|H:1|Y:3 2.84754684617547e-13 2.84754684617547e-13 0.000126869862562897 13 lung:2|kidney:3|uterus:1|thyroid:1|skin:3|testis:1|brain:1|head_neck:1 ENST00000289153 2 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 PIK3R1 X582 X:14 582 sp:14 3.86307734142432e-13 3.86307734142432e-13 2.4672549624812e-05 14 kidney:1|uterus:3|bowel:2|prostate:3|brain:5 ENST00000274335 5 splice site 0.0 0.0 0.0 14.0 14.0 0.0 0.0 0.0 1.0 VHL X114 X:16 114 sp:16 4.1399817297452e-13 1.59672092517867e-11 4.1399817297452e-13 16 kidney:16 ENST00000256474 2 splice site 0.0 0.0 0.0 16.0 16.0 0.0 0.0 0.0 1.0 FGFR3 G370 G:8 370 C:8 4.34020637676127e-13 1.26541904804658e-07 4.34020637676127e-13 8 bladder:8 ENST00000260795 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SF3B1 K666 K:13 666 Q:1|T:5|E:2|M:2|N:3 7.28542711318273e-13 7.28542711318273e-13 0.0223351164287247 13 eye:2|lung:3|unk:2|liver:1|pancreas:1|skin:1|blood:2|breast:1 ENST00000335508 6 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 VHL S65 S:17 65 P:2|T:1|W:1|*:7|L:6 7.40697442383436e-13 8.85718727613334e-13 7.40697442383436e-13 17 kidney:15|pancreas:1|bladder:1 ENST00000256474 2 single residue 10.0 7.0 0.0 0.0 17.0 0.5882352941176471 0.4117647058823529 0.0 0.0 CDK4 K22 K:7 22 Q:2|M:5 8.18881825213307e-13 1.63666408116003e-09 8.18881825213307e-13 7 skin:6|blood:1 ENST00000257904 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 TP53 F134 F:24 134 C:4|S:1|V:5|I:2|L:12 8.60419732135027e-13 8.60419732135027e-13 0.0486120618556088 24 lung:4|lymph:1|ovary:1|uterus:1|unk:1|pancreas:3|skin:3|bowel:1|stomach:4|prostate:1|breast:3|head_neck:1 ENST00000269305 4 single residue 24.0 0.0 0.0 0.0 24.0 1.0 0.0 0.0 0.0 KIT W557 W:12 557 R:6|S:2|C:1|G:3 9.16539228195011e-13 9.16539228195011e-13 6.58354276202613e-08 12 thymus:1|unk:1|skin:1|soft_tissue:4|testis:5 ENST00000288135 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 EGFR R222 R:16 222 C:15|H:1 1.97405001559138e-12 5.56176774610315e-07 1.97405001559138e-12 16 bowel:1|skin:1|brain:13|breast:1 ENST00000275493 2 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 EGFR R252 R:16 252 P:3|C:9|H:4 1.97405001559138e-12 2.45269939269633e-07 1.97405001559138e-12 16 bowel:1|stomach:2|prostate:1|brain:12 ENST00000275493 2 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 FGFR3 K650 K:10 650 T:1|E:7|M:1|N:1 2.00679702410257e-12 2.00679702410257e-12 2.98546229728467e-06 10 kidney:1|bladder:4|skin:2|brain:2|blood:1 ENST00000260795 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 SMARCA4 G1232 G:17 1232 S:11|C:2|D:2|V:2 2.11467605706404e-12 2.11467605706404e-12 0.0152055023363205 17 lung:5|kidney:2|lymph:1|unk:1|skin:1|stomach:3|soft_tissue:1|brain:3 ENST00000358026 2 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 ARID2 S297 S:20 297 S:4|F:16 2.22766268353864e-12 1.0244464597364e-07 2.22766268353864e-12 20 unk:5|skin:15 ENST00000334344 6 single residue 20.0 0.0 0.0 0.0 20.0 1.0 0.0 0.0 0.0 H1-2 A180 A:22 180 P:1|A:21 3.16251091470805e-12 3.16251091470805e-12 2.28305523313821e-07 22 lung:5|thymus:1|lymph:1|bladder:6|breast:8|head_neck:1 ENST00000343677 2 single residue 22.0 0.0 0.0 0.0 22.0 1.0 0.0 0.0 0.0 ERBB3 G284 G:13 284 R:13 4.0960348053e-12 4.0960348053e-12 0.143035693681575 13 cervix:1|biliary_tract:1|unk:1|uterus:1|bladder:2|bowel:3|stomach:3|breast:1 ENST00000267101 3 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 ERBB2 D769 D:18 769 H:6|Y:12 4.15162464558809e-12 4.15162464558809e-12 5.56463110958722e-10 18 cervix:1|ovary:1|bladder:3|bowel:1|stomach:7|breast:5 ENST00000269571 5 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 PTEN X70 X:15 70 sp:15 5.42733937707976e-12 5.42733937707976e-12 0.0108834223463364 15 lung:1|uterus:4|unk:1|thyroid:2|skin:1|prostate:1|brain:1|breast:4 ENST00000371953 3 splice site 0.0 0.0 0.0 15.0 15.0 0.0 0.0 0.0 1.0 FGFR1 K687 K:11 687 E:8|*:1|K:1|N:1 6.61101232218435e-12 6.61101232218435e-12 1.36643015095665e-10 11 lung:1|liver:1|bladder:1|soft_tissue:1|brain:6|blood:1 ENST00000425967 3 single residue 10.0 1.0 0.0 0.0 11.0 0.9090909090909091 0.09090909090909091 0.0 0.0 SOX17 S403 S:8 403 I:8 7.18958994628799e-12 0.0300485458503063 7.18958994628799e-12 8 ovary:1|uterus:7 ENST00000297316 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 VHL X155 X:14 155 sp:14 7.83200669499252e-12 3.49464330875098e-10 7.83200669499252e-12 14 kidney:14 ENST00000256474 2 splice site 0.0 0.0 0.0 14.0 14.0 0.0 0.0 0.0 1.0 NUP93 E14 E:16 14 K:16 8.46294727163906e-12 1.42990126862823e-09 8.46294727163906e-12 16 lung:3|thyroid:1|bladder:2|breast:9|head_neck:1 ENST00000308159 5 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 STK11 X155 X:14 155 sp:14 1.05267328502366e-11 6.78201573421544e-11 1.05267328502366e-11 14 lung:13|bowel:1 ENST00000326873 7 splice site 0.0 0.0 0.0 14.0 14.0 0.0 0.0 0.0 1.0 STK11 X245 X:13 245 sp:13 1.05267328502366e-11 6.78201573421544e-11 1.05267328502366e-11 13 lung:12|cervix:1 ENST00000326873 7 splice site 0.0 0.0 0.0 13.0 13.0 0.0 0.0 0.0 1.0 TP53 M246 M:37 246 R:2|T:3|V:16|I:10|K:3|L:3 1.10580578627633e-11 1.10580578627633e-11 0.000713751603437584 37 biliary_tract:1|bowel:1|stomach:3|brain:5|head_neck:2|lung:10|kidney:2|thyroid:1|pancreas:2|bladder:2|prostate:3|soft_tissue:2|breast:3 ENST00000269305 4 single residue 37.0 0.0 0.0 0.0 37.0 1.0 0.0 0.0 0.0 TP53 R110 R:43 110 P:11|C:6|H:1|L:25 1.12989197548727e-11 1.12989197548727e-11 6.79824789454293e-06 43 thymus:1|liver:1|bowel:3|skin:1|stomach:3|brain:1|head_neck:5|vulva:1|lung:13|kidney:1|ovary:2|lymph:1|unk:1|thyroid:1|pancreas:2|bladder:1|prostate:2|soft_tissue:2|breast:1 ENST00000269305 4 single residue 43.0 0.0 0.0 0.0 43.0 1.0 0.0 0.0 0.0 PTEN C136 C:14 136 R:9|F:2|Y:2|*:1 1.52906668939568e-11 1.52906668939568e-11 0.0165293147379595 14 lung:1|kidney:1|uterus:4|skin:1|bowel:1|brain:3|breast:2|head_neck:1 ENST00000371953 3 single residue 13.0 1.0 0.0 0.0 14.0 0.9285714285714286 0.07142857142857142 0.0 0.0 PTEN G132 G:17 132 A:3|S:3|D:8|V:3 1.52906668939568e-11 1.52906668939568e-11 3.29739670526468e-05 17 lung:1|uterus:3|skin:1|bowel:1|soft_tissue:1|prostate:2|brain:8 ENST00000371953 3 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 CCND1 Y44 Y:8 44 C:1|S:1|D:3|F:1|H:1|*:1 1.6522455227078e-11 3.99274676730324e-07 1.6522455227078e-11 8 lymph:7|blood:1 ENST00000227507 2 single residue 7.0 1.0 0.0 0.0 8.0 0.875 0.125 0.0 0.0 SMARCA4 R1192 R:17 1192 P:1|C:9|H:7 1.6996864443455e-11 1.6996864443455e-11 0.0710671307107628 17 lung:2|kidney:1|uterus:1|liver:1|pancreas:1|bladder:1|skin:2|stomach:3|brain:4|breast:1 ENST00000358026 2 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 INPPL1 A1185 A:11 1185 D:11 1.76182303850515e-11 1.76182303850515e-11 7.86009889037855e-08 11 adrenal_gland:4|bladder:1|prostate:2|stomach:1|soft_tissue:1|brain:1|head_neck:1 ENST00000298229 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 SMAD4 P356 P:16 356 R:2|S:3|H:1|L:10 2.1533538671879e-11 2.1533538671879e-11 1.34233950335313e-07 16 lung:1|biliary_tract:1|pancreas:1|bowel:9|stomach:4 ENST00000342988 3 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 ERBB3 S846 S:10 846 I:10 2.5930810120753e-11 2.5930810120753e-11 0.0107353574041666 10 lung:1|ampulla_of_vater:1|bladder:1|bowel:3|stomach:3|breast:1 ENST00000267101 3 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 CDKN2A X51 X:20 51 sp:20 3.09188955285343e-11 3.09188955285343e-11 0.0127100032037222 20 lung:2|biliary_tract:1|unk:1|liver:3|bladder:2|skin:6|bone:1|head_neck:4 ENST00000579755 1 splice site 0.0 0.0 0.0 20.0 20.0 0.0 0.0 0.0 1.0 STK11 D194 D:14 194 V:2|G:1|H:1|Y:7|N:3 3.49153886629741e-11 3.49153886629741e-11 8.98578208214298e-11 14 lung:11|prostate:1|breast:1|head_neck:1 ENST00000326873 7 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 FBXW7 R658 R:20 658 Q:4|R:1|*:15 3.79187313312857e-11 3.79187313312857e-11 0.000399594406181409 20 lung:1|cervix:2|uterus:6|bladder:1|bowel:7|skin:1|brain:1|head_neck:1 ENST00000281708 4 single residue 5.0 15.0 0.0 0.0 20.0 0.25 0.75 0.0 0.0 AR W742 W:7 742 C:6|L:1 4.10229788253528e-11 0.013039242511197 4.10229788253528e-11 7 prostate:7 ENST00000374690 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 TP53 V143 V:26 143 A:7|E:2|G:5|M:12 5.17740247574383e-11 5.17740247574383e-11 0.000448732030377674 26 liver:2|bowel:3|skin:4|stomach:1|brain:1|head_neck:2|lung:3|kidney:1|lymph:1|ovary:1|uterus:1|pancreas:2|bladder:1|soft_tissue:1|prostate:1|breast:1 ENST00000269305 4 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 CCND1 P287 P:12 287 A:1|R:1|S:5|T:1|L:4 5.65945826265419e-11 5.65945826265419e-11 3.47922499578711e-10 12 cervix:1|uterus:6|bladder:1|bowel:1|skin:1|head_neck:2 ENST00000227507 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 CIC R1512 R:11 1512 C:2|S:1|H:5|L:3 6.01782827522399e-11 3.88977018398984e-07 6.01782827522399e-11 11 bladder:1|brain:9|breast:1 ENST00000575354 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 FBXW7 R689 R:19 689 Q:5|W:14 6.54359310325598e-11 6.54359310325598e-11 0.00025477423951351 19 lung:1|uterus:6|unk:1|bowel:6|brain:3|breast:1|head_neck:1 ENST00000281708 4 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 MAP2K1 E203 E:16 203 V:2|K:14 6.86894927003352e-11 6.86894927003352e-11 0.00176761966988447 16 lung:1|unk:1|pancreas:1|bladder:1|skin:6|bowel:1|stomach:1|brain:2|blood:1|breast:1 ENST00000307102 5 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 FOXA1 I176 I:11 176 V:7|M:4 7.65741901652142e-11 1.14705215020311e-05 7.65741901652142e-11 11 lung:1|breast:10 ENST00000250448 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 DICER1 E1813 E:11 1813 Q:3|A:1|G:6|K:1 1.03770440524625e-10 1.03770440524625e-10 0.00153104560890897 11 ovary:1|uterus:3|thyroid:2|bowel:3|skin:1|brain:1 ENST00000393063 1 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PTPN11 E76 E:13 76 A:2|Q:1|G:3|K:7 1.05060575176458e-10 1.05060575176458e-10 5.13579838888689e-10 13 lung:2|bowel:2|brain:7|blood:2 ENST00000351677 2 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 KNSTRN S24 S:13 24 F:13 1.46994689964654e-10 0.000139879899044539 1.46994689964654e-10 13 skin:13 ENST00000249776 8 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 EGFR L747 L:8 747 P:3|S:1|F:1|L:3 1.56584028674065e-10 2.45345058167487e-05 1.56584028674065e-10 8 lung:8 ENST00000275493 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 ACVR1 G328 G:7 328 E:5|V:2 2.17276202583146e-10 0.000294658906570245 2.17276202583146e-10 7 brain:7 ENST00000263640 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CCND1 T286 T:9 286 A:1|I:8 2.39494812952936e-10 1.95435491935497e-09 2.39494812952936e-10 9 uterus:6|bladder:1|bowel:1|stomach:1 ENST00000227507 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 VHL L89 L:15 89 P:5|H:9|L:1 2.84655898510653e-10 6.71329096674301e-09 2.84655898510653e-10 15 lung:1|kidney:13|bladder:1 ENST00000256474 2 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 NOTCH2 T235 T:10 235 S:10 2.89150962196842e-10 2.89150962196842e-10 9.2453502620966e-10 10 kidney:1|lymph:5|thymus:1|biliary_tract:2|soft_tissue:1 ENST00000256646 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 CIC R1515 R:10 1515 C:5|H:5 3.21216725843384e-10 0.000153657185791609 3.21216725843384e-10 10 bowel:1|brain:9 ENST00000575354 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 NFE2L2 L30 L:12 30 P:2|R:1|F:7|H:2 3.26181329917381e-10 3.26181329917381e-10 0.00206357313698891 12 lung:2|kidney:2|liver:1|pancreas:1|stomach:1|soft_tissue:1|head_neck:4 ENST00000397062 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 S127 S:48 127 P:4|C:1|S:1|T:1|F:31|Y:10 3.33046155258552e-10 3.33046155258552e-10 6.37466151428426e-05 48 bowel:8|skin:6|stomach:3|brain:4|head_neck:4|lung:8|ovary:3|unk:2|uterus:2|pancreas:3|bladder:2|prostate:1|breast:2 ENST00000269305 4 single residue 48.0 0.0 0.0 0.0 48.0 1.0 0.0 0.0 0.0 SF3B1 N626 N:8 626 D:2|H:2|Y:4 3.34579354448327e-10 3.34579354448327e-10 0.000418613717139048 8 lung:1|uterus:1|skin:2|blood:3|breast:1 ENST00000335508 6 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 EGFR E709 E:16 709 A:2|Q:1|K:13 3.57278117431548e-10 3.57278117431548e-10 3.92155500716554e-09 16 lung:9|ovary:1|bladder:1|skin:1|brain:3|breast:1 ENST00000275493 2 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 TP53 Q136 Q:31 136 P:3|E:10|H:1|*:16|L:1 3.67041636006903e-10 3.67041636006903e-10 0.00485997332080842 31 liver:2|skin:3|bowel:1|stomach:1|brain:5|head_neck:6|lung:1|kidney:1|ovary:1|pancreas:1|bladder:1|penis:1|soft_tissue:1|breast:6 ENST00000269305 4 single residue 15.0 16.0 0.0 0.0 31.0 0.4838709677419355 0.5161290322580645 0.0 0.0 ERBB3 H228 H:8 228 Q:6|R:2 4.40384663213664e-10 3.32989935808776e-09 4.40384663213664e-10 8 bladder:6|stomach:2 ENST00000267101 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 TP53 C277 C:28 277 F:20|G:1|W:1|Y:3|*:3 5.26918784417401e-10 5.26918784417401e-10 0.0390268717757736 28 biliary_tract:1|liver:1|bowel:1|stomach:3|bone:2|brain:3|blood:1|head_neck:1|lung:8|ovary:1|unk:2|thyroid:1|bladder:2|breast:1 ENST00000269305 4 single residue 25.0 3.0 0.0 0.0 28.0 0.8928571428571429 0.10714285714285714 0.0 0.0 ERCC2 T484 T:8 484 A:4|M:4 5.94542228261946e-10 1.34896596258922e-07 5.94542228261946e-10 8 liver:1|bladder:7 ENST00000391945 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 MYOD1 L122 L:7 122 R:5|L:1|M:1 6.09833928477344e-10 0.000655188824561365 6.09833928477344e-10 7 lung:2|soft_tissue:5 ENST00000250003 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERG R354 R:6 354 R:6 7.20192472847528e-10 0.68406956179586 7.20192472847528e-10 6 prostate:6 ENST00000288319 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 FOXA1 H247 H:10 247 Q:2|R:3|Y:4|L:1 8.78143675660237e-10 8.47047636049798e-08 8.78143675660237e-10 10 prostate:7|breast:3 ENST00000250448 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 GNAS Q227 Q:11 227 H:4|K:3|L:4 9.92974560347528e-10 9.92974560347528e-10 5.88887070725712e-07 11 lung:6|ovary:1|thyroid:1|liver:1|bowel:1|skin:1 ENST00000371085 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PARP1 G500 G:6 500 G:6 1.14977828803329e-09 0.00253211565019232 1.14977828803329e-09 6 stomach:6 ENST00000366794 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CTNNB1 H36 H:8 36 P:7|Y:1 1.23306160353623e-09 1.65617842319544e-05 1.23306160353623e-09 8 liver:7|skin:1 ENST00000349496 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 NFE2L2 W24 W:11 24 R:7|C:3|S:1 1.25844116981492e-09 1.25844116981492e-09 0.0746153893059644 11 lung:3|kidney:2|liver:1|bladder:1|skin:1|stomach:1|head_neck:2 ENST00000397062 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 HRAS K117 K:9 117 R:1|N:8 1.3704997221253e-09 1.3704997221253e-09 1.06828703575746e-05 9 thymus:3|bladder:4|breast:1|head_neck:1 ENST00000451590 1 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 B2M X23 X:17 23 sp:17 1.71517108741211e-09 1.71517108741211e-09 2.41380332956831e-07 17 lung:1|lymph:3|bowel:9|skin:2|stomach:2 ENST00000558401 1 splice site 0.0 0.0 0.0 17.0 17.0 0.0 0.0 0.0 1.0 ATM R3008 R:15 3008 C:6|H:7|L:2 1.74669303192438e-09 1.74669303192438e-09 0.000448934701262579 15 lung:3|lymph:2|pancreas:2|bladder:1|bowel:6|stomach:1 ENST00000278616 4 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 EGFR L62 L:10 62 R:10 1.90253284860552e-09 1.90253284860552e-09 7.8092106322181e-08 10 lung:4|brain:6 ENST00000275493 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 KIT D820 D:11 820 A:1|E:2|V:3|G:1|Y:4 1.92130177530644e-09 1.92130177530644e-09 6.41250636051226e-09 11 unk:2|soft_tissue:6|penis:1|testis:2 ENST00000288135 5 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PTEN D92 D:18 92 E:7|V:2|G:3|H:2|Y:2|N:2 2.81113657455673e-09 2.81113657455673e-09 0.0417698796814483 18 lung:2|ovary:1|uterus:4|bowel:2|soft_tissue:1|brain:3|breast:4|head_neck:1 ENST00000371953 3 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 NFE2L2 Q26 Q:9 26 P:2|R:1|H:1|K:4|L:1 2.81197869371358e-09 2.81197869371358e-09 0.000675454344122469 9 lung:4|uterus:1|liver:2|stomach:1|breast:1 ENST00000397062 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 TET1 P1752 P:10 1752 P:8|S:2 2.87599149463378e-09 0.144899050528886 2.87599149463378e-09 10 skin:10 ENST00000373644 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 FGFR4 V550 V:11 550 L:7|M:4 2.94821142153483e-09 6.56297518381661e-08 2.94821142153483e-09 11 uterus:1|soft_tissue:4|breast:6 ENST00000292408 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 KRAS A59 A:12 59 A:2|T:5|E:1|G:4 3.18311796039066e-09 3.18311796039066e-09 0.119155916653858 12 lung:3|kidney:1|bowel:2|stomach:2|prostate:1|blood:3 ENST00000311936 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 PTEN X343 X:15 343 sp:15 3.31241208014574e-09 3.31241208014574e-09 0.146202446385628 15 lung:4|kidney:2|cervix:1|ovary:1|uterus:3|unk:1|bladder:1|brain:1|breast:1 ENST00000371953 3 splice site 0.0 0.0 0.0 15.0 15.0 0.0 0.0 0.0 1.0 DIS3 D488 D:11 488 A:1|G:1|H:1|Y:1|N:7 3.46224146992256e-09 3.46224146992256e-09 0.00103265189805854 11 lung:4|kidney:1|brain:1|blood:4|head_neck:1 ENST00000377767 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 CDH1 D254 D:11 254 E:2|Y:4|N:5 3.46819951743406e-09 6.09866366931617e-05 3.46819951743406e-09 11 bowel:1|stomach:9|penis:1 ENST00000261769 5 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 CDKN2A E88 E:27 88 E:1|*:18|K:8 3.70241974704799e-09 3.70241974704799e-09 0.00156164901349785 27 lung:1|cervix:1|unk:4|pancreas:2|skin:10|soft_tissue:1|brain:1|head_neck:7 ENST00000579755 1 single residue 9.0 18.0 0.0 0.0 27.0 0.3333333333333333 0.6666666666666666 0.0 0.0 MYD88 S243 S:7 243 N:7 4.78040181622355e-09 0.00039935875696231 4.78040181622355e-09 7 lymph:6|breast:1 ENST00000396334 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CA G1007 G:10 1007 R:9|D:1 5.22206675389205e-09 5.22206675389205e-09 0.519814380676741 10 lung:1|cervix:1|kidney:1|uterus:1|bladder:1|bowel:2|breast:2|head_neck:1 ENST00000263967 3 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 PTEN Y68 Y:11 68 C:2|H:6|*:2|N:1 5.27636707238447e-09 5.27636707238447e-09 0.000817166529741825 11 uterus:2|bowel:4|prostate:1|brain:3|breast:1 ENST00000371953 3 single residue 9.0 2.0 0.0 0.0 11.0 0.8181818181818182 0.18181818181818182 0.0 0.0 GNAQ T96 T:9 96 S:9 6.19698434219041e-09 6.19698434219041e-09 0.0269865579057709 9 lung:1|kidney:2|lymph:2|biliary_tract:1|liver:1|pancreas:1|prostate:1 ENST00000286548 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SETD2 R1625 R:13 1625 C:6|S:1|H:5|L:1 6.83579094550133e-09 6.83579094550133e-09 0.216851597848245 13 lung:3|kidney:3|uterus:1|thyroid:1|skin:3|brain:1|breast:1 ENST00000409792 3 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 SDHA L639 L:7 639 V:7 7.18357325737371e-09 0.00193661441110013 7.18357325737371e-09 7 lymph:6|brain:1 ENST00000264932 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CA T1025 T:8 1025 A:7|S:1 8.49323741228694e-09 8.49323741228694e-09 0.000123329023596293 8 uterus:4|bowel:2|breast:2 ENST00000263967 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SOS1 N233 N:7 233 Y:7 9.34176359993697e-09 9.34176359993697e-09 9.48075749252071e-06 7 lung:4|uterus:3 ENST00000402219 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CA C378 C:9 378 R:3|F:4|Y:2 9.90900884246927e-09 9.90900884246927e-09 0.290246206008005 9 ovary:1|uterus:2|pancreas:1|stomach:1|brain:2|breast:2 ENST00000263967 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 FOXA1 M253 M:7 253 R:2|T:1|K:4 1.06201814393352e-08 2.45577470029742e-05 1.06201814393352e-08 7 prostate:6|breast:1 ENST00000250448 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PTEN X212 X:19 212 sp:19 1.13062485515142e-08 1.13062485515142e-08 0.188331197570594 19 lung:1|cervix:1|kidney:1|uterus:3|liver:1|pancreas:1|bowel:2|prostate:1|brain:3|breast:4|head_neck:1 ENST00000371953 3 splice site 0.0 0.0 0.0 19.0 19.0 0.0 0.0 0.0 1.0 EIF1AX G9 G:11 9 R:3|D:6|V:2 1.14561094279715e-08 1.14561094279715e-08 5.5178481073965e-05 11 eye:2|lung:2|ovary:1|thyroid:4|bowel:1|head_neck:1 ENST00000379607 5 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 FGFR3 G380 G:11 380 R:11 1.20520209570854e-08 1.20520209570854e-08 1.92593877951814e-05 11 bladder:5|skin:1|stomach:1|head_neck:3|breast:1 ENST00000260795 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 TCF7L2 R471 R:14 471 C:8|S:2|H:4 1.30421488952988e-08 4.70189555409422e-05 1.30421488952988e-08 14 bowel:13|stomach:1 ENST00000543371 1 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 RHOA R5 R:17 5 Q:8|W:8|L:1 1.52155472277533e-08 1.52155472277533e-08 1.62131206376002e-05 17 lymph:6|bowel:1|stomach:8|breast:2 ENST00000418115 1 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 PIK3CA D350 D:12 350 V:1|G:5|N:6 2.16867928564548e-08 2.16867928564548e-08 0.498470543667972 12 lung:1|uterus:2|pancreas:1|skin:1|bowel:2|stomach:1|brain:1|breast:2|head_neck:1 ENST00000263967 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 MAP2K1 G128 G:10 128 R:1|D:5|V:4 2.50287570681096e-08 2.50287570681096e-08 0.0232849969721096 10 lung:2|biliary_tract:1|bowel:4|skin:2|stomach:1 ENST00000307102 5 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 PTEN H93 H:12 93 P:1|R:6|Y:4|L:1 2.90249120822907e-08 2.90249120822907e-08 0.164360402936616 12 uterus:3|bladder:1|bowel:1|skin:1|soft_tissue:1|brain:2|breast:2|head_neck:1 ENST00000371953 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 SF3B1 K741 K:10 741 Q:1|T:1|E:2|*:1|N:5 3.09082474257009e-08 3.09082474257009e-08 0.00569295419522759 10 lung:2|kidney:1|liver:3|skin:1|prostate:1|blood:1|breast:1 ENST00000335508 6 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 BRAF L597 L:10 597 Q:3|R:3|S:2|V:1|L:1 3.69731390598529e-08 3.69731390598529e-08 2.02991648284039e-07 10 uterus:1|skin:6|prostate:1|brain:1|blood:1 ENST00000288602 6 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 RAC1 A178 A:12 178 V:12 4.64277494505764e-08 4.64277494505764e-08 9.74195114660295e-07 12 lung:1|cervix:1|bowel:2|soft_tissue:1|brain:1|head_neck:6 ENST00000356142 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 VHL S80 S:11 80 R:5|S:1|I:1|N:4 4.73394777910565e-08 4.73394777910565e-08 6.97321027097565e-08 11 kidney:10|pancreas:1 ENST00000256474 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PIK3CB E1051 E:11 1051 G:2|K:9 5.95653540276479e-08 5.95653540276479e-08 0.419276125145897 11 lung:1|kidney:2|biliary_tract:1|bladder:1|bowel:1|prostate:2|stomach:1|soft_tissue:1|breast:1 ENST00000289153 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ACVR1 R258 R:6 258 G:5|M:1 6.8256854220096e-08 0.000294658906570245 6.8256854220096e-08 6 stomach:1|brain:5 ENST00000263640 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 TP63 R379 R:17 379 C:14|S:1|H:2 8.73352761228577e-08 1.81996200319709e-05 8.73352761228577e-08 17 unk:1|skin:14|bowel:1|blood:1 ENST00000264731 3 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 MAX H28 H:6 28 R:6 8.97388616000743e-08 9.82154745912981e-06 8.97388616000743e-08 6 uterus:5|testis:1 ENST00000358664 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ERCC2 Y24 Y:5 24 C:5 9.89549248621122e-08 6.17326174317745e-05 9.89549248621122e-08 5 bladder:5 ENST00000391945 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTPN11 Q510 Q:9 510 E:1|H:3|L:5 1.01220941991159e-07 1.01220941991159e-07 0.00946086431679308 9 skin:2|soft_tissue:1|brain:3|blood:3 ENST00000351677 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 RAF1 S259 S:12 259 P:3|C:1|S:1|F:7 1.11523704110657e-07 1.11523704110657e-07 0.106905966919833 12 lung:3|lymph:1|unk:1|biliary_tract:1|bladder:1|skin:3|bowel:1|head_neck:1 ENST00000251849 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 ARAF S214 S:12 214 P:2|A:3|C:1|S:1|F:4|Y:1 1.11680470351445e-07 1.11680470351445e-07 0.00118239503945889 12 lung:5|kidney:2|biliary_tract:1|skin:2|bowel:1|blood:1 ENST00000377045 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 G154 G:25 154 C:1|D:1|V:23 1.14503702283721e-07 0.000276606718993076 1.14503702283721e-07 25 lung:17|unk:1|liver:1|pancreas:1|bladder:1|bowel:3|stomach:1 ENST00000269305 4 single residue 25.0 0.0 0.0 0.0 25.0 1.0 0.0 0.0 0.0 MYC P74 P:12 74 Q:1|R:1|S:4|T:2|L:4 1.17925450406565e-07 1.17925450406565e-07 0.0136897647675308 12 lung:4|lymph:1|uterus:1|skin:2|soft_tissue:2|blood:1|head_neck:1 ENST00000377970 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 X332 X:48 332 sp:48 1.24919927952202e-07 1.24919927952202e-07 0.732278354103218 48 biliary_tract:1|liver:3|bowel:3|skin:2|stomach:2|brain:4|head_neck:5|lung:8|ovary:3|lymph:1|uterus:4|bladder:4|prostate:1|soft_tissue:1|breast:6 ENST00000269305 4 splice site 0.0 0.0 0.0 48.0 48.0 0.0 0.0 0.0 1.0 ETV6 X11 X:5 11 sp:5 1.46221405832525e-07 0.196173598742318 1.46221405832525e-07 5 lymph:5 ENST00000396373 4 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 PIK3CA P104 P:11 104 R:1|L:10 1.61020365998658e-07 1.61020365998658e-07 0.0475944355057251 11 lung:1|ovary:1|uterus:2|skin:2|brain:1|breast:3|head_neck:1 ENST00000263967 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 CTCF R377 R:12 377 C:9|H:3 1.65354504881555e-07 1.5105982975144e-05 1.65354504881555e-07 12 uterus:8|bowel:2|skin:2 ENST00000264010 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 L130 L:30 130 P:2|R:4|V:13|F:10|H:1 2.06448059790326e-07 2.06448059790326e-07 0.0734271048699656 30 lung:4|ovary:2|unk:1|liver:1|pancreas:5|bowel:5|stomach:5|prostate:1|brain:5|breast:1 ENST00000269305 4 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 FGFR3 S371 S:5 371 C:5 2.53645379864409e-07 0.000599687829141248 2.53645379864409e-07 5 bladder:5 ENST00000260795 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 SF3B1 G742 G:8 742 D:8 2.57040955470615e-07 3.94564952357995e-06 2.57040955470615e-07 8 lung:1|cervix:1|kidney:1|blood:5 ENST00000335508 6 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 RB1 X500 X:10 500 sp:10 2.59331922255693e-07 2.59331922255693e-07 1 10 lung:2|cervix:1|kidney:1|liver:1|bladder:2|skin:1|soft_tissue:1|head_neck:1 ENST00000267163 4 splice site 0.0 0.0 0.0 10.0 10.0 0.0 0.0 0.0 1.0 CDK6 L65 L:9 65 L:9 2.88833961402471e-07 1 2.88833961402471e-07 9 cervix:1|bladder:8 ENST00000265734 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 TGFBR1 S241 S:15 241 S:2|*:1|L:12 3.26275109634539e-07 4.27869864747226e-06 3.26275109634539e-07 15 ovary:1|biliary_tract:1|uterus:1|ampulla_of_vater:1|pancreas:1|bowel:9|stomach:1 ENST00000374994 4 single residue 14.0 1.0 0.0 0.0 15.0 0.9333333333333333 0.06666666666666667 0.0 0.0 PAX5 V26 V:9 26 G:9 3.7223934800935e-07 3.7223934800935e-07 0.00650462014561782 9 bowel:3|stomach:3|prostate:1|pleura:1|head_neck:1 ENST00000358127 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 STAT3 H410 H:6 410 P:2|R:4 3.91618125206497e-07 0.00289676522104762 3.91618125206497e-07 6 lung:1|liver:4|breast:1 ENST00000264657 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 TP63 X194 X:5 194 sp:5 3.99900800749029e-07 0.21991304469231 3.99900800749029e-07 5 head_neck:5 ENST00000264731 3 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 FBXW7 S582 S:12 582 P:1|S:1|L:10 4.01507799087038e-07 0.000239452431961817 4.01507799087038e-07 12 lung:1|bowel:10|stomach:1 ENST00000281708 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RHOA A161 A:7 161 T:2|V:5 4.19520880623079e-07 4.70657536214838e-05 4.19520880623079e-07 7 lymph:1|bladder:6 ENST00000418115 1 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 EP300 Y1414 Y:7 1414 C:6|D:1 4.30606176073522e-07 4.30606176073522e-07 0.00974926835475028 7 lung:3|bladder:2|stomach:1|head_neck:1 ENST00000263253 7 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERBB3 E332 E:14 332 Q:1|K:13 4.75403254856063e-07 0.000203067440144683 4.75403254856063e-07 14 lung:2|cervix:1|bladder:10|stomach:1 ENST00000267101 3 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 EP300 W1466 W:8 1466 R:1|C:2|G:1|*:1|L:3 4.82359795206628e-07 4.82359795206628e-07 0.000266694300861485 8 lymph:1|bowel:4|stomach:2|head_neck:1 ENST00000263253 7 single residue 7.0 1.0 0.0 0.0 8.0 0.875 0.125 0.0 0.0 EP300 Y1467 Y:8 1467 C:1|S:1|D:2|H:1|K:1|N:2 4.82359795206628e-07 4.82359795206628e-07 0.000546815850432701 8 lymph:3|uterus:1|bladder:1|brain:1|head_neck:2 ENST00000263253 7 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 MET V1070 V:5 1070 A:2|R:1|E:2 5.23737105519572e-07 0.0478571817782497 5.23737105519572e-07 5 kidney:5 ENST00000397752 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 MET M1250 M:6 1250 T:6 5.23737105519572e-07 0.00266919217049537 5.23737105519572e-07 6 kidney:5|unk:1 ENST00000397752 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PIK3CA M1 M:6 1 V:6 6.05536749909866e-07 4.06234538221146e-05 6.05536749909866e-07 6 uterus:1|brain:5 ENST00000263967 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SDHA S445 S:10 445 S:9|L:1 7.30147582086515e-07 0.000402373463036954 7.30147582086515e-07 10 lymph:6|bladder:1|stomach:1|prostate:1|breast:1 ENST00000264932 6 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 SMAD4 G419 G:8 419 R:1|V:3|W:4 7.34281451772137e-07 2.67997336600557e-05 7.34281451772137e-07 8 bowel:7|stomach:1 ENST00000342988 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SMARCA4 M781 M:9 781 V:2|I:6|L:1 8.44219689247448e-07 8.44219689247448e-07 0.0325753089028093 9 lung:1|biliary_tract:1|pancreas:1|stomach:3|brain:3 ENST00000358026 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 FOXA1 R261 R:9 261 C:3|S:1|G:4|H:1 8.57798327208341e-07 0.0473550136963832 8.57798327208341e-07 9 bladder:1|prostate:8 ENST00000250448 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 FBXW7 Y545 Y:7 545 C:6|*:1 9.29532572203721e-07 9.29532572203721e-07 0.00512636347982339 7 uterus:1|bowel:1|stomach:3|breast:1|head_neck:1 ENST00000281708 4 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 ERBB4 L798 L:11 798 P:2|R:7|H:1|L:1 1.05290421298124e-06 0.00242732425739046 1.05290421298124e-06 11 kidney:1|bladder:1|bowel:1|stomach:8 ENST00000342788 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 VHL S111 S:10 111 P:1|R:2|S:1|N:6 1.145547139501e-06 1.36136453924963e-05 1.145547139501e-06 10 kidney:10 ENST00000256474 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 KIT Y823 Y:6 823 C:1|D:5 1.19299853504738e-06 1.19299853504738e-06 8.91932849796417e-05 6 bowel:1|soft_tissue:3|testis:2 ENST00000288135 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RB1 X474 X:9 474 sp:9 1.34474780240449e-06 1.34474780240449e-06 0.0456112816851603 9 lung:4|skin:3|bowel:1|brain:1 ENST00000267163 4 splice site 0.0 0.0 0.0 9.0 9.0 0.0 0.0 0.0 1.0 BCL6 R594 R:12 594 Q:10|G:2 1.36919837925192e-06 0.000305695415891525 1.36919837925192e-06 12 uterus:2|bladder:2|bowel:7|head_neck:1 ENST00000232014 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 CDH1 X278 X:6 278 sp:6 1.38818265516344e-06 0.00147574159240955 1.38818265516344e-06 6 breast:6 ENST00000261769 5 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 U2AF1 Q157 Q:4 157 P:2|R:2 1.6150389142363e-06 0.133053910621136 1.6150389142363e-06 4 blood:4 ENST00000291552 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ATM N2875 N:8 2875 S:5|T:2|K:1 1.70075948226044e-06 1.70075948226044e-06 0.00670763842945354 8 liver:2|bowel:2|prostate:3|breast:1 ENST00000278616 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PTPN11 E69 E:11 69 D:2|K:9 1.80787202544705e-06 1.80787202544705e-06 2.96157432179419e-06 11 bowel:2|stomach:1|brain:6|breast:2 ENST00000351677 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 FUBP1 R430 R:12 430 C:11|H:1 1.92218538564378e-06 0.000505791585181038 1.92218538564378e-06 12 cervix:1|uterus:6|bowel:2|stomach:1|prostate:1|breast:1 ENST00000370768 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 MTOR F1888 F:8 1888 V:1|I:4|L:3 1.9720024293449e-06 0.000163268331184898 1.9720024293449e-06 8 kidney:5|uterus:2|bowel:1 ENST00000361445 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 MTOR L2427 L:7 2427 Q:4|R:3 1.9720024293449e-06 0.000143429913832681 1.9720024293449e-06 7 kidney:5|uterus:1|brain:1 ENST00000361445 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 FBXW7 G423 G:10 423 A:1|V:8|*:1 2.07099491720386e-06 2.07099491720386e-06 5.71298909278636e-06 10 uterus:5|bowel:2|skin:1|blood:1|head_neck:1 ENST00000281708 4 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 CDKN2A X153 X:16 153 sp:16 2.19076953414902e-06 4.34157389568348e-05 2.19076953414902e-06 16 lung:1|skin:2|stomach:3|head_neck:10 ENST00000579755 1 splice site 0.0 0.0 0.0 16.0 16.0 0.0 0.0 0.0 1.0 EPAS1 P531 P:4 531 A:1|S:1|L:2 2.7458396480587e-06 0.773058119831692 2.7458396480587e-06 4 adrenal_gland:4 ENST00000263734 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PTEN Y27 Y:10 27 C:2|D:4|H:1|*:1|N:2 2.97185296362565e-06 2.97185296362565e-06 0.70273229219433 10 ovary:1|uterus:2|thyroid:1|bowel:1|stomach:1|brain:3|breast:1 ENST00000371953 3 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 VHL N78 N:9 78 S:4|D:2|Y:2|K:1 3.06267165122873e-06 3.06267165122873e-06 5.70668100028727e-06 9 kidney:8|pancreas:1 ENST00000256474 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 ACVR1 R206 R:8 206 H:8 3.09527109977675e-06 0.0285425921052009 3.09527109977675e-06 8 uterus:6|brain:2 ENST00000263640 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 AKT1 L52 L:5 52 R:4|H:1 3.30992340624556e-06 0.000888272542180874 3.30992340624556e-06 5 kidney:1|breast:4 ENST00000349310 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 IL7R K395 K:12 395 R:4|T:3|K:2|M:1|N:2 3.44668089191901e-06 0.032194475015754 3.44668089191901e-06 12 lung:1|uterus:1|bladder:1|skin:2|bowel:1|stomach:6 ENST00000303115 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 SMARCA4 R1189 R:12 1189 Q:7|G:3|*:1|L:1 3.57045753293949e-06 3.57045753293949e-06 1 12 lung:1|unk:2|pancreas:1|bladder:2|skin:1|bowel:1|brain:2|head_neck:2 ENST00000358026 2 single residue 11.0 1.0 0.0 0.0 12.0 0.9166666666666666 0.08333333333333333 0.0 0.0 PTPN11 G503 G:9 503 V:8|G:1 3.59243867419399e-06 3.59243867419399e-06 0.0417339692902096 9 lung:3|bladder:1|bowel:1|stomach:3|blood:1 ENST00000351677 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 ARID1A G2087 G:13 2087 R:10|E:3 3.82110215304271e-06 3.82110215304271e-06 0.00750605484235632 13 lung:1|cervix:1|uterus:1|pancreas:1|bowel:2|skin:2|stomach:5 ENST00000324856 7 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 CASP8 R292 R:13 292 Q:4|W:9 4.27696951759218e-06 4.27696951759218e-06 0.389999914807029 13 lymph:1|uterus:1|unk:1|bladder:1|skin:2|head_neck:4|breast:3 ENST00000358485 4 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 TP53 P152 P:38 152 P:2|Q:1|R:2|S:2|T:2|K:1|L:28 4.46613497758463e-06 4.46613497758463e-06 0.0164080522274503 38 bowel:10|skin:1|stomach:3|brain:3|head_neck:2|lung:8|lymph:1|unk:1|pancreas:3|bladder:3|prostate:1|soft_tissue:1|breast:1 ENST00000269305 4 single residue 38.0 0.0 0.0 0.0 38.0 1.0 0.0 0.0 0.0 STK11 X307 X:8 307 sp:8 4.6367505963321e-06 0.000113486007252898 4.6367505963321e-06 8 lung:8 ENST00000326873 7 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 MTOR E1799 E:12 1799 K:12 5.32869235354167e-06 5.32869235354167e-06 1 12 cervix:1|lymph:1|uterus:2|bowel:3|skin:1|prostate:1|brain:1|blood:1|breast:1 ENST00000361445 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 KMT2D R5179 R:10 5179 P:1|C:2|H:5|L:2 5.54656680344052e-06 5.54656680344052e-06 1 10 lung:2|uterus:1|thyroid:1|liver:1|bladder:2|skin:1|stomach:1|breast:1 ENST00000301067 7 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 EZH2 K515 K:8 515 R:8 5.87241204357667e-06 5.87241204357667e-06 0.000209873216423542 8 thymus:1|skin:1|soft_tissue:1|testis:3|brain:2 ENST00000320356 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 ERBB3 M91 M:12 91 I:12 5.89385412710216e-06 0.00728864009578802 5.89385412710216e-06 12 uterus:1|bladder:9|breast:1|head_neck:1 ENST00000267101 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 SPOP M117 M:7 117 V:7 6.81660266090703e-06 0.00236847923653854 6.81660266090703e-06 7 cervix:1|uterus:6 ENST00000347630 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CD E1021 E:8 1021 K:8 7.49932571758753e-06 0.00262996333732157 7.49932571758753e-06 8 lymph:4|unk:1|bladder:1|skin:2 ENST00000377346 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 TP53 H168 H:19 168 P:2|R:12|Y:1|L:4 7.59679170174124e-06 7.59679170174124e-06 0.00349538421091801 19 lung:4|liver:1|pancreas:1|bowel:5|stomach:3|bone:1|brain:2|head_neck:1|breast:1 ENST00000269305 4 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 CCND3 I290 I:4 290 R:1|K:3 7.73194808545737e-06 0.0377686510881379 7.73194808545737e-06 4 lymph:4 ENST00000372991 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 R267 R:36 267 P:8|Q:4|R:1|W:15|G:3|L:5 8.41645737021107e-06 8.41645737021107e-06 0.00721499609030284 36 lung:10|kidney:1|ovary:1|liver:2|bowel:8|skin:1|stomach:2|brain:8|head_neck:1|blood:1|breast:1 ENST00000269305 4 single residue 36.0 0.0 0.0 0.0 36.0 1.0 0.0 0.0 0.0 TP53 A161 A:26 161 P:1|S:4|T:12|D:7|V:2 8.6597657861634e-06 8.6597657861634e-06 0.00013483967297678 26 lung:4|ovary:1|liver:1|pancreas:4|bladder:6|bowel:3|prostate:1|brain:1|breast:3|head_neck:2 ENST00000269305 4 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 SMO L412 L:6 412 F:5|L:1 8.71010004332757e-06 1 8.71010004332757e-06 6 bladder:1|brain:5 ENST00000249373 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RB1 X830 X:11 830 sp:11 9.08044118841068e-06 9.08044118841068e-06 0.336191204869751 11 lung:2|uterus:1|bladder:4|skin:1|brain:3 ENST00000267163 4 splice site 0.0 0.0 0.0 11.0 11.0 0.0 0.0 0.0 1.0 PIK3CA E365 E:13 365 V:2|K:11 9.15583894618766e-06 9.15583894618766e-06 1 13 uterus:2|bladder:3|bowel:2|stomach:1|brain:1|breast:3|head_neck:1 ENST00000263967 3 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 EP300 X1429 X:6 1429 sp:6 1.24478126439434e-05 0.00147217880222451 1.24478126439434e-05 6 lung:1|kidney:4|head_neck:1 ENST00000263253 7 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 PRKCI R480 R:10 480 C:5|S:3|H:2 1.24954912334541e-05 8.98414226176886e-05 1.24954912334541e-05 10 ovary:1|bowel:6|stomach:3 ENST00000295797 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 PIK3R2 G373 G:9 373 R:9 1.37716918085153e-05 1.37716918085153e-05 0.0667992288809348 9 lung:1|uterus:3|ampulla_of_vater:1|bladder:1|bowel:1|stomach:1|breast:1 ENST00000222254 8 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 PIK3R2 D557 D:9 557 G:1|H:1|Y:5|N:2 1.37716918085153e-05 1.37716918085153e-05 1 9 lung:1|uterus:1|bladder:1|prostate:2|testis:1|breast:2|head_neck:1 ENST00000222254 8 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SMAD4 G352 G:11 352 A:2|R:3|E:3|V:1|*:1|L:1 1.37739318604283e-05 1.37739318604283e-05 0.137542620612855 11 lung:3|biliary_tract:1|ampulla_of_vater:1|pancreas:1|bowel:2|stomach:3 ENST00000342988 3 single residue 10.0 1.0 0.0 0.0 11.0 0.9090909090909091 0.09090909090909091 0.0 0.0 PTPRT E548 E:12 548 G:1|K:11 1.45349357736284e-05 0.0388462009711605 1.45349357736284e-05 12 ovary:1|skin:11 ENST00000373198 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 TP53 K164 K:13 164 E:9|*:4 1.47223833465579e-05 1.47223833465579e-05 0.019866033154031 13 lung:5|ovary:2|bladder:1|bowel:2|stomach:1|brain:1|breast:1 ENST00000269305 4 single residue 9.0 4.0 0.0 0.0 13.0 0.6923076923076923 0.3076923076923077 0.0 0.0 MET F1200 F:4 1200 V:1|I:3 1.50401186839176e-05 0.176321951998998 1.50401186839176e-05 4 kidney:4 ENST00000397752 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ERCC2 Y72 Y:4 72 C:4 1.6086225598154e-05 0.00274217683391378 1.6086225598154e-05 4 bladder:4 ENST00000391945 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CTCF Y226 Y:4 226 C:4 1.65503913101184e-05 0.0290058995373033 1.65503913101184e-05 4 breast:4 ENST00000264010 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 RHOA E47 E:11 47 K:11 1.69502190537709e-05 0.000460203695335467 1.69502190537709e-05 11 bladder:8|skin:1|soft_tissue:1|head_neck:1 ENST00000418115 1 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ERBB2 L869 L:4 869 R:4 1.8308455270165e-05 0.0324689180119828 1.8308455270165e-05 4 breast:4 ENST00000269571 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 STK11 S216 S:12 216 S:1|F:11 1.94249168129621e-05 1.94249168129621e-05 0.000985054050851474 12 lung:8|biliary_tract:1|bladder:1|skin:1|head_neck:1 ENST00000326873 7 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 KNSTRN V12 V:5 12 V:2|G:3 2.11447649416683e-05 0.000903210797623523 2.11447649416683e-05 5 lung:1|stomach:4 ENST00000249776 8 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CTNNB1 I35 I:8 35 S:7|I:1 2.1250479736793e-05 2.1250479736793e-05 0.00444116014949192 8 lung:1|uterus:2|liver:3|skin:2 ENST00000349496 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 TP53 Q144 Q:23 144 P:3|H:1|*:17|L:2 2.17738171086558e-05 2.17738171086558e-05 7.60590065325666e-05 23 lung:12|ovary:1|unk:1|uterus:1|liver:1|pancreas:1|bladder:1|bowel:1|stomach:1|head_neck:2|breast:1 ENST00000269305 4 single residue 6.0 17.0 0.0 0.0 23.0 0.2608695652173913 0.7391304347826086 0.0 0.0 MET Y1230 Y:4 1230 C:1|S:1|H:2 2.26527320268023e-05 0.286189335304694 2.26527320268023e-05 4 kidney:4 ENST00000397752 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 F109 F:16 109 S:6|C:5|V:3|F:1|I:1 2.36567137864909e-05 2.36567137864909e-05 0.065613144337551 16 lung:1|lymph:1|ovary:2|skin:4|bowel:2|stomach:2|soft_tissue:1|brain:3 ENST00000269305 4 single residue 16.0 0.0 0.0 0.0 16.0 1.0 0.0 0.0 0.0 KIT V560 V:7 560 A:1|D:3|V:2|G:1 2.5201075105254e-05 2.5201075105254e-05 2.82423372868783e-05 7 lung:1|soft_tissue:4|stomach:1|testis:1 ENST00000288135 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 TP53 G105 G:28 105 R:2|C:13|S:2|D:4|V:6|G:1 2.55614724011675e-05 2.55614724011675e-05 0.00266314781477412 28 lung:12|ovary:4|liver:1|bladder:1|bowel:1|skin:1|prostate:1|stomach:1|testis:1|brain:1|head_neck:4 ENST00000269305 4 single residue 28.0 0.0 0.0 0.0 28.0 1.0 0.0 0.0 0.0 SMAD4 E330 E:11 330 Q:2|G:2|*:1|K:6 2.64651886505787e-05 2.64651886505787e-05 0.0764479473881833 11 lung:1|unk:1|bladder:1|bowel:4|stomach:3|breast:1 ENST00000342988 3 single residue 10.0 1.0 0.0 0.0 11.0 0.9090909090909091 0.09090909090909091 0.0 0.0 TP53 T125 T:30 125 P:3|A:2|R:6|K:3|M:16 2.69550487311592e-05 2.69550487311592e-05 0.0331521349705651 30 lung:6|kidney:1|ovary:1|unk:1|thyroid:1|bladder:2|bowel:9|skin:1|stomach:1|brain:3|head_neck:2|breast:2 ENST00000269305 4 single residue 30.0 0.0 0.0 0.0 30.0 1.0 0.0 0.0 0.0 PTEN G127 G:14 127 R:5|E:5|V:3|*:1 3.07055801003565e-05 3.07055801003565e-05 0.0884009695397923 14 lung:3|uterus:4|liver:1|skin:1|stomach:1|soft_tissue:1|testis:1|brain:2 ENST00000371953 3 single residue 13.0 1.0 0.0 0.0 14.0 0.9285714285714286 0.07142857142857142 0.0 0.0 STK11 G242 G:9 242 R:1|V:4|W:3|G:1 3.43165464187048e-05 0.000941887303657865 3.43165464187048e-05 9 lung:9 ENST00000326873 7 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 MYC S161 S:11 161 L:11 3.61888337278651e-05 3.61888337278651e-05 0.0164498637834994 11 lung:1|ovary:1|uterus:1|bowel:3|skin:2|head_neck:3 ENST00000377970 2 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 KRAS L19 L:12 19 F:12 3.71800769373073e-05 3.71800769373073e-05 1 12 lung:3|lymph:1|biliary_tract:1|unk:1|bladder:2|bowel:2|stomach:1|blood:1 ENST00000311936 3 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RB1 X654 X:8 654 sp:8 3.72826658507451e-05 3.72826658507451e-05 1 8 lung:2|uterus:1|bladder:1|skin:1|soft_tissue:1|brain:2 ENST00000267163 4 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 PIK3CA R115 R:11 115 P:3|Q:1|L:7 3.87074236670905e-05 3.87074236670905e-05 1 11 lung:1|ovary:1|uterus:3|thyroid:1|bladder:1|bowel:2|skin:1|head_neck:1 ENST00000263967 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PREX2 L50 L:9 50 V:5|L:4 4.17095917701041e-05 0.0115924936968643 4.17095917701041e-05 9 bowel:2|stomach:7 ENST00000288368 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 H3C3 K37 K:6 37 K:1|M:5 4.31460935771132e-05 0.864473573825661 4.31460935771132e-05 6 bladder:1|skin:1|head_neck:4 ENST00000540144 1 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RHOA Y34 Y:6 34 C:5|F:1 4.70657536214838e-05 4.70657536214838e-05 0.000230075680535408 6 bowel:2|stomach:4 ENST00000418115 1 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SMARCA4 R1243 R:12 1243 P:1|W:9|G:1|L:1 4.81608011502394e-05 4.81608011502394e-05 1 12 kidney:2|lymph:1|ovary:1|biliary_tract:1|uterus:1|pancreas:2|bone:1|stomach:1|brain:1|breast:1 ENST00000358026 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RB1 X445 X:7 445 sp:7 4.86028548096026e-05 4.86028548096026e-05 0.021645498860223 7 lung:4|liver:1|bladder:1|brain:1 ENST00000267163 4 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 RHOA L57 L:6 57 V:6 5.06876440826244e-05 0.000460203695335467 5.06876440826244e-05 6 unk:1|stomach:5 ENST00000418115 1 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PTEN X268 X:12 268 sp:12 5.16990792357805e-05 5.16990792357805e-05 1 12 lung:2|uterus:1|bowel:2|skin:1|brain:4|breast:2 ENST00000371953 3 splice site 0.0 0.0 0.0 12.0 12.0 0.0 0.0 0.0 1.0 VHL D121 D:9 121 V:1|G:2|Y:6 5.25111408060234e-05 0.000525515800247804 5.25111408060234e-05 9 kidney:9 ENST00000256474 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 CDH1 X177 X:6 177 sp:6 5.36416082793524e-05 0.00266287940282979 5.36416082793524e-05 6 bowel:1|stomach:5 ENST00000261769 5 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 FBXW7 D520 D:11 520 V:1|G:1|H:1|Y:2|N:6 5.41988026669828e-05 0.00123384885818608 5.41988026669828e-05 11 lung:2|bladder:3|bowel:5|head_neck:1 ENST00000281708 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 RUNX1 R201 R:7 201 Q:2|G:1|*:4 5.51149603976628e-05 0.180069863896887 5.51149603976628e-05 7 lung:1|bowel:1|blood:5 ENST00000300305 3 single residue 3.0 4.0 0.0 0.0 7.0 0.42857142857142855 0.5714285714285714 0.0 0.0 VHL W88 W:9 88 R:2|*:5|L:2 5.74074593167752e-05 0.000554684648130705 5.74074593167752e-05 9 kidney:9 ENST00000256474 2 single residue 4.0 5.0 0.0 0.0 9.0 0.4444444444444444 0.5555555555555556 0.0 0.0 PTEN G129 G:12 129 R:3|E:4|V:2|G:2|*:1 5.95070750294617e-05 5.95070750294617e-05 0.0165293147379595 12 lung:2|uterus:5|prostate:1|soft_tissue:1|brain:2|breast:1 ENST00000371953 3 single residue 11.0 1.0 0.0 0.0 12.0 0.9166666666666666 0.08333333333333333 0.0 0.0 TP53 P250 P:24 250 P:1|R:1|L:22 5.99198048007855e-05 5.99198048007855e-05 0.171829711012643 24 lung:5|kidney:1|ovary:2|biliary_tract:1|unk:1|uterus:1|pancreas:1|bowel:4|skin:1|stomach:3|brain:4 ENST00000269305 4 single residue 24.0 0.0 0.0 0.0 24.0 1.0 0.0 0.0 0.0 CDKN2A L130 L:8 130 Q:4|R:3|V:1 6.02822296383367e-05 6.02822296383367e-05 0.00580302877866397 8 pancreas:4|skin:3|stomach:1 ENST00000579755 1 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 CDKN2A Y129 Y:9 129 C:3|*:6 6.02822296383367e-05 6.02822296383367e-05 0.66967851396472 9 lung:3|biliary_tract:1|pancreas:2|stomach:1|head_neck:2 ENST00000579755 1 single residue 3.0 6.0 0.0 0.0 9.0 0.3333333333333333 0.6666666666666666 0.0 0.0 CDH1 X440 X:7 440 sp:7 6.09866366931617e-05 6.09866366931617e-05 0.0017736054696059 7 bladder:1|skin:1|stomach:4|breast:1 ENST00000261769 5 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 EGFR H304 H:5 304 Y:5 7.43524648342889e-05 0.137011842000972 7.43524648342889e-05 5 brain:5 ENST00000275493 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 EGFR T363 T:7 363 A:2|I:4|N:1 7.43524648342889e-05 0.000606797916026388 7.43524648342889e-05 7 lung:1|lymph:1|brain:5 ENST00000275493 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 TP53 E271 E:53 271 Q:7|V:5|*:14|K:27 7.50411582407331e-05 0.00067157685335367 7.50411582407331e-05 53 cervix:1|biliary_tract:1|liver:1|skin:1|bowel:3|stomach:2|brain:1|head_neck:4|lung:10|ovary:1|unk:1|thyroid:1|pancreas:1|bladder:18|prostate:3|breast:4 ENST00000269305 4 single residue 39.0 14.0 0.0 0.0 53.0 0.7358490566037735 0.2641509433962264 0.0 0.0 RHOA E40 E:14 40 Q:9|D:1|V:1|*:1|K:2 7.89360770697566e-05 7.89360770697566e-05 9.87121162063449e-05 14 lung:2|unk:3|bladder:1|stomach:1|head_neck:6|breast:1 ENST00000418115 1 single residue 13.0 1.0 0.0 0.0 14.0 0.9285714285714286 0.07142857142857142 0.0 0.0 VHL L158 L:9 158 P:3|Q:1|V:4|L:1 8.08917220235343e-05 0.000704134685447287 8.08917220235343e-05 9 kidney:9 ENST00000256474 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 VHL P86 P:9 86 R:1|S:4|T:2|L:2 8.08917220235343e-05 0.000693493817474633 8.08917220235343e-05 9 kidney:9 ENST00000256474 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 VHL V74 V:7 74 D:5|V:1|G:1 8.08917220235343e-05 0.000554684648130705 8.08917220235343e-05 7 kidney:7 ENST00000256474 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 DICER1 D1810 D:9 1810 A:1|V:2|H:1|Y:2|N:3 8.22450136351905e-05 8.45094805228046e-05 8.22450136351905e-05 9 lung:1|uterus:4|thyroid:1|bowel:2|skin:1 ENST00000393063 1 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 PIK3CA N107 N:6 107 S:3|I:2|N:1 8.25147220432943e-05 8.25147220432943e-05 0.216014434875453 6 lung:1|uterus:1|prostate:2|breast:2 ENST00000263967 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ASXL2 E330 E:10 330 Q:2|D:1|K:7 9.4223821280924e-05 0.975250179653826 9.4223821280924e-05 10 bladder:8|brain:1|breast:1 ENST00000435504 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 PAK5 M173 M:12 173 I:12 9.55412663311122e-05 0.108126156369184 9.55412663311122e-05 12 unk:1|skin:11 ENST00000353224 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 MAP2K2 F57 F:6 57 V:2|L:4 9.70235389918942e-05 9.70235389918942e-05 0.342986581081331 6 pancreas:1|skin:2|stomach:1|breast:1|head_neck:1 ENST00000262948 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 IRF4 K123 K:3 123 R:3 9.97106212012724e-05 1 9.97106212012724e-05 3 blood:3 ENST00000380956 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PIM1 S97 S:10 97 R:2|S:3|T:1|N:4 0.000100262103792936 0.000388596903271533 0.000100262103792936 10 lymph:9|blood:1 ENST00000373509 5 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 RUNX1 R162 R:4 162 S:1|G:2|K:1 0.000113108365223981 1 0.000113108365223981 4 blood:4 ENST00000300305 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 B2M L12 L:7 12 P:4|Q:2|L:1 0.000115092463101106 0.000115092463101106 0.059887125560747 7 lung:1|lymph:3|unk:1|bowel:1|stomach:1 ENST00000558401 1 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 TP53 X32 X:20 32 sp:20 0.000127539579249016 0.000127539579249016 0.0664008622068533 20 lung:2|kidney:3|liver:2|bladder:1|bowel:1|skin:1|prostate:1|testis:1|brain:4|head_neck:4 ENST00000269305 4 splice site 0.0 0.0 0.0 20.0 20.0 0.0 0.0 0.0 1.0 KEAP1 R260 R:10 260 Q:4|*:2|L:4 0.000128688268304168 0.000128688268304168 0.464571770056663 10 lung:4|kidney:2|cervix:1|thyroid:1|liver:2 ENST00000171111 5 single residue 8.0 2.0 0.0 0.0 10.0 0.8 0.2 0.0 0.0 MTOR C1483 C:7 1483 R:2|F:2|W:1|Y:2 0.000130995916923082 0.000130995916923082 0.000201376344266898 7 kidney:4|testis:1|brain:1|breast:1 ENST00000361445 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 EGFR P596 P:8 596 P:1|R:1|S:2|L:4 0.000132911422078455 0.0244862846069981 0.000132911422078455 8 bowel:1|skin:1|brain:6 ENST00000275493 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 EIF1AX G15 G:7 15 D:4|V:1|G:2 0.00013328049767376 0.00013328049767376 0.631069438232641 7 eye:2|lung:1|bowel:1|soft_tissue:1|brain:2 ENST00000379607 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MTOR V2006 V:7 2006 F:4|V:1|I:1|L:1 0.000143429913832681 0.000143429913832681 0.0109744673866623 7 kidney:3|lymph:1|uterus:1|brain:2 ENST00000361445 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERBB3 T355 T:6 355 P:1|A:1|I:4 0.000144623354388927 0.000144623354388927 0.557808888760882 6 biliary_tract:1|bladder:1|bowel:1|stomach:1|breast:2 ENST00000267101 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 NRAS G60 G:7 60 E:1|V:1|G:5 0.00014613533141846 0.00014613533141846 0.00752486578384679 7 lung:3|skin:3|bowel:1 ENST00000369535 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 XPO1 R749 R:11 749 Q:10|*:1 0.000146532020311594 0.000146532020311594 0.160831599854659 11 uterus:4|unk:1|pancreas:1|bowel:4|breast:1 ENST00000401558 2 single residue 10.0 1.0 0.0 0.0 11.0 0.9090909090909091 0.09090909090909091 0.0 0.0 NOTCH1 F853 F:4 853 C:2|I:2 0.00015082022409177 0.0641999693184651 0.00015082022409177 4 lung:4 ENST00000277541 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 EIF1AX R13 R:12 13 P:1|C:2|G:1|H:4|L:4 0.000161841956275204 0.000161841956275204 0.406333075143057 12 eye:1|lung:1|uterus:3|bowel:1|skin:1|stomach:1|prostate:1|brain:3 ENST00000379607 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RB1 X127 X:7 127 sp:7 0.000170187578635711 0.000170187578635711 0.0243980364043014 7 lung:4|unk:1|liver:1|brain:1 ENST00000267163 4 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 PIM1 G28 G:8 28 A:1|D:6|V:1 0.000171510114503651 0.0053081188974104 0.000171510114503651 8 lymph:8 ENST00000373509 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SF3B1 G740 G:9 740 E:7|V:2 0.000175436453406427 0.000175436453406427 0.0817321173399099 9 lung:4|biliary_tract:1|pancreas:1|bladder:2|blood:1 ENST00000335508 6 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SPOP F125 F:6 125 C:1|V:1|I:1|L:3 0.00017822188506056 1 0.00017822188506056 6 prostate:6 ENST00000347630 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 KDM6A X1336 X:6 1336 sp:6 0.000181209491771618 0.00305903400488818 0.000181209491771618 6 bladder:5|blood:1 ENST00000377967 4 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 RB1 X203 X:9 203 sp:9 0.000197456625104954 0.000197456625104954 1 9 lung:1|biliary_tract:1|unk:1|uterus:1|liver:1|bladder:1|skin:1|stomach:1|soft_tissue:1 ENST00000267163 4 splice site 0.0 0.0 0.0 9.0 9.0 0.0 0.0 0.0 1.0 TP53 V172 V:18 172 D:5|F:12|G:1 0.000199168992960357 0.000199168992960357 0.0337899594306307 18 lung:7|lymph:1|biliary_tract:1|unk:1|thyroid:1|bowel:1|stomach:3|brain:1|breast:1|head_neck:1 ENST00000269305 4 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 ERBB2 G776 G:6 776 S:2|V:4 0.000214743024488163 0.000214743024488163 0.00414347216644636 6 bladder:1|bowel:2|stomach:3 ENST00000269571 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CTCF H284 H:6 284 P:1|Y:4|N:1 0.000216979970306031 1 0.000216979970306031 6 breast:6 ENST00000264010 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SMAD4 E526 E:11 526 Q:2|A:1|D:1|V:1|*:3|K:3 0.000220507250911314 0.000220507250911314 0.804226688249402 11 lung:3|biliary_tract:2|pancreas:1|bowel:3|stomach:1|breast:1 ENST00000342988 3 single residue 8.0 3.0 0.0 0.0 11.0 0.7272727272727273 0.2727272727272727 0.0 0.0 SMAD4 D355 D:7 355 V:2|G:4|Y:1 0.000220507250911314 0.000220507250911314 0.214876221275966 7 pancreas:2|bowel:3|prostate:1|stomach:1 ENST00000342988 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERCC2 S246 S:7 246 S:2|F:2|Y:3 0.000220631227265414 0.0196600079630409 0.000220631227265414 7 bladder:6|soft_tissue:1 ENST00000391945 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 IRF4 C99 C:7 99 R:4|C:2|Y:1 0.000227652714506587 0.0955651174695425 0.000227652714506587 7 lung:1|lymph:4|pancreas:1|head_neck:1 ENST00000380956 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 FGFR2 R203 R:6 203 C:2|H:4 0.000229894911861478 1 0.000229894911861478 6 bowel:6 ENST00000358487 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 STAT3 S614 S:5 614 R:5 0.000238843518230703 0.0413926471524043 0.000238843518230703 5 lymph:4|stomach:1 ENST00000264657 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CIC R201 R:7 201 R:1|W:6 0.000256730145082327 0.00778865596954941 0.000256730145082327 7 lymph:1|stomach:1|brain:5 ENST00000575354 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PDGFRA E229 E:7 229 V:1|*:1|K:5 0.00025793882615122 1 0.00025793882615122 7 skin:2|brain:5 ENST00000257290 5 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 FOXO1 S22 S:7 22 P:3|S:1|W:3 0.000262158567401401 0.00827850999099778 0.000262158567401401 7 lymph:4|bowel:2|prostate:1 ENST00000379561 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERBB2 V659 V:5 659 D:1|E:2|V:2 0.000268822656434572 0.0130177162606892 0.000268822656434572 5 lung:4|stomach:1 ENST00000269571 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 MAP2K1 C121 C:6 121 S:5|C:1 0.000271001007196765 0.000271001007196765 1 6 lung:2|lymph:1|biliary_tract:1|bladder:1|stomach:1 ENST00000307102 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 TP53 T155 T:18 155 P:7|T:1|I:2|N:8 0.000276203605125193 0.000276203605125193 0.0198247281673658 18 lung:7|liver:1|pancreas:1|soft_tissue:1|brain:5|breast:3 ENST00000269305 4 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 PTPRD S431 S:17 431 S:1|*:1|L:15 0.000280826354999932 0.000280826354999932 0.0288286067487385 17 lung:1|uterus:5|skin:4|bowel:3|stomach:1|penis:1|prostate:1|brain:1 ENST00000356435 5 single residue 16.0 1.0 0.0 0.0 17.0 0.9411764705882353 0.058823529411764705 0.0 0.0 CASP8 R127 R:13 127 Q:8|*:5 0.000302848994448202 0.000302848994448202 0.132814642599753 13 uterus:5|pancreas:1|bladder:2|bowel:2|head_neck:2|breast:1 ENST00000358485 4 single residue 8.0 5.0 0.0 0.0 13.0 0.6153846153846154 0.38461538461538464 0.0 0.0 RNF43 H86 H:4 86 R:2|Y:2 0.000317636175436398 0.399938185910855 0.000317636175436398 4 stomach:4 ENST00000407977 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 BRAF L485 L:6 485 S:1|F:1|W:3|*:1 0.000333433570458539 0.000333433570458539 0.0684045325905179 6 lung:1|biliary_tract:1|bladder:2|skin:2 ENST00000288602 6 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 BCL2 A131 A:10 131 D:7|T:2|V:1 0.000338355303555859 0.000942377740333269 0.000338355303555859 10 lymph:9|brain:1 ENST00000333681 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 STK11 X288 X:8 288 sp:8 0.000339166875807386 0.000339166875807386 0.00365452984534313 8 lung:6|stomach:1|brain:1 ENST00000326873 7 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 CTNNB1 W383 W:6 383 R:3|C:1|S:1|G:1 0.00034738723293938 0.00034738723293938 0.0124171994964138 6 liver:2|pancreas:1|bowel:3 ENST00000349496 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PTEN A126 A:11 126 S:4|D:3|V:3|G:1 0.000355422424396546 0.000355422424396546 0.0210814442323736 11 unk:1|uterus:2|soft_tissue:1|stomach:2|brain:1|breast:4 ENST00000371953 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 PTEN C105 C:7 105 R:1|S:1|G:1|W:1|Y:2|*:1 0.000363990202363233 0.000363990202363233 0.00565128852492496 7 skin:3|soft_tissue:1|brain:3 ENST00000371953 3 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 TGFBR2 D471 D:12 471 V:1|Y:1|N:10 0.000365084489940418 0.000365084489940418 0.320075455041597 12 lung:2|cervix:1|uterus:1|pancreas:3|bowel:4|stomach:1 ENST00000295754 5 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 PTEN C124 C:8 124 R:1|S:4|G:1|Y:2 0.000369460106003662 0.000369460106003662 0.0108834223463364 8 uterus:1|thyroid:1|bowel:1|prostate:1|breast:4 ENST00000371953 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PTPRT L668 L:5 668 V:3|L:2 0.000383122377927383 1 0.000383122377927383 5 stomach:5 ENST00000373198 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 RAC1 N111 N:5 111 S:1|I:1|K:3 0.000384600240645875 0.000384600240645875 1 5 thyroid:1|bowel:1|skin:1|soft_tissue:1|blood:1 ENST00000356142 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 GATA2 C352 C:4 352 R:1|C:1|F:1|*:1 0.000386130527618172 0.146639133758541 0.000386130527618172 4 lung:4 ENST00000341105 2 single residue 3.0 1.0 0.0 0.0 4.0 0.75 0.25 0.0 0.0 MAP2K1 Y130 Y:5 130 C:3|H:1|N:1 0.000390930809868608 0.000390930809868608 0.193603808036947 5 lung:1|lymph:2|liver:1|bowel:1 ENST00000307102 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 NFE2L2 D77 D:7 77 V:1|G:3|H:2|Y:1 0.000440112681913558 0.000440112681913558 0.575267875359785 7 lung:2|kidney:1|cervix:1|liver:2|skin:1 ENST00000397062 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 EGFR T263 T:4 263 P:3|I:1 0.000443937077361959 0.204421107108247 0.000443937077361959 4 brain:4 ENST00000275493 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 MTOR M2327 M:6 2327 V:1|I:5 0.000446236341703313 0.000446236341703313 0.706460150477979 6 kidney:2|uterus:1|bladder:1|bowel:1|brain:1 ENST00000361445 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 DNMT1 E51 E:5 51 K:5 0.000457369167019088 1 0.000457369167019088 5 uterus:5 ENST00000340748 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 SETD2 Y1666 Y:6 1666 C:4|H:1|*:1 0.000460067179768372 0.000460067179768372 1 6 lung:2|kidney:2|pancreas:1|bone:1 ENST00000409792 3 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 RHOA G62 G:7 62 R:3|E:3|V:1 0.000460203695335467 0.000460203695335467 0.00426963345924189 7 bowel:1|stomach:4|head_neck:1|breast:1 ENST00000418115 1 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 RB1 X46 X:7 46 sp:7 0.000467623736978692 0.000467623736978692 0.140689654970362 7 lung:4|uterus:1|bladder:1|prostate:1 ENST00000267163 4 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 BRAF G596 G:8 596 R:4|C:1|S:1|D:1|V:1 0.000495016870209048 0.000495016870209048 0.00222080335405382 8 lung:5|bladder:1|brain:1|blood:1 ENST00000288602 6 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 EP300 C1164 C:6 1164 S:1|Y:5 0.000497503425615413 0.000497503425615413 0.0274005402204872 6 bladder:3|bone:1|head_neck:2 ENST00000263253 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 FGFR2 Y375 Y:5 375 C:5 0.000502673004420345 0.000502673004420345 0.0908710472200663 5 cervix:1|uterus:2|biliary_tract:1|bowel:1 ENST00000358487 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 MST1 G673 G:6 673 S:6 0.000504582989691505 0.000504582989691505 0.252331648748305 6 lung:1|lymph:2|ovary:1|breast:1|head_neck:1 ENST00000449682 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 MAP2K1 T386 T:3 386 T:3 0.000512968367623452 0.0162055721109116 0.000512968367623452 3 bladder:3 ENST00000307102 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 MAP3K1 S1330 S:10 1330 W:2|L:8 0.000515913573968169 0.000515913573968169 1 10 ovary:1|unk:1|uterus:1|bowel:2|stomach:2|brain:1|breast:2 ENST00000399503 3 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 FOXA1 S250 S:6 250 F:5|Y:1 0.000517133957868793 0.674108100437389 0.000517133957868793 6 breast:6 ENST00000250448 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SMAD4 W524 W:9 524 R:1|C:6|S:1|L:1 0.000523513784646524 0.000523513784646524 1 9 lung:1|pancreas:3|bowel:2|stomach:2|breast:1 ENST00000342988 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 TP53 L257 L:17 257 P:4|Q:7|R:4|V:1|L:1 0.000534067822950071 0.000534067822950071 0.00166850995346688 17 ovary:1|uterus:1|unk:1|liver:1|pancreas:1|bladder:2|bowel:6|prostate:3|breast:1 ENST00000269305 4 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 STK11 X97 X:8 97 sp:8 0.000549663500781769 0.000549663500781769 0.00460427868871404 8 lung:6|unk:1|stomach:1 ENST00000326873 7 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 VHL R161 R:10 161 Q:2|*:7|L:1 0.000554684648130705 0.000554684648130705 0.00271531464293943 10 kidney:7|adrenal_gland:1|stomach:1|breast:1 ENST00000256474 2 single residue 3.0 7.0 0.0 0.0 10.0 0.3 0.7 0.0 0.0 KEAP1 R470 R:10 470 C:7|S:1|H:2 0.000575237923548754 0.000575237923548754 0.00262221927300804 10 lung:7|skin:1|head_neck:2 ENST00000171111 5 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 ARAF P216 P:4 216 R:1|L:3 0.000593515828701691 1 0.000593515828701691 4 biliary_tract:3|soft_tissue:1 ENST00000377045 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 GNAQ R183 R:10 183 Q:6|*:4 0.000622969148509286 0.000628209846995182 0.000622969148509286 10 eye:4|pancreas:1|bowel:3|skin:1|penis:1 ENST00000286548 4 single residue 6.0 4.0 0.0 0.0 10.0 0.6 0.4 0.0 0.0 RB1 X702 X:6 702 sp:6 0.000627863387091009 0.000627863387091009 0.57152195865935 6 eye:1|lung:1|bladder:2|soft_tissue:1|head_neck:1 ENST00000267163 4 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 EP300 H1451 H:5 1451 P:1|Q:1|R:1|H:1|L:1 0.000628378364028597 0.000628378364028597 1 5 lung:1|uterus:1|bladder:1|brain:1|breast:1 ENST00000263253 7 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN G165 G:12 165 R:5|E:6|*:1 0.000639515145732353 0.000639515145732353 0.3607853162853 12 lung:2|kidney:1|uterus:3|bowel:1|skin:1|brain:3|blood:1 ENST00000371953 3 single residue 11.0 1.0 0.0 0.0 12.0 0.9166666666666666 0.08333333333333333 0.0 0.0 PTEN X85 X:8 85 sp:8 0.000639515145732353 0.000639515145732353 0.89326717650545 8 cervix:1|unk:1|uterus:1|prostate:2|brain:3 ENST00000371953 3 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 RHOA T37 T:6 37 A:1|S:1|I:4 0.00065068897287312 0.00065068897287312 0.0312929378101637 6 lymph:1|thyroid:1|bowel:3|head_neck:1 ENST00000418115 1 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SMAD4 C363 C:6 363 R:2|S:1|F:2|Y:1 0.00065164187004951 0.00065164187004951 1 6 lung:1|bladder:1|bowel:1|stomach:2|breast:1 ENST00000342988 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RAC1 G12 G:6 12 R:3|V:3 0.000661400410008793 0.00720141225078055 0.000661400410008793 6 unk:2|testis:4 ENST00000356142 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 FOXO1 S205 S:5 205 S:2|Y:1|N:2 0.00070080979931149 0.184054471573764 0.00070080979931149 5 lymph:4|bowel:1 ENST00000379561 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 KRAS A11 A:8 11 A:6|T:2 0.000725138589585693 0.000725138589585693 0.0570219406473822 8 lung:4|pancreas:3|vulva:1 ENST00000311936 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 GSK3B X239 X:3 239 sp:3 0.000748704539069988 1 0.000748704539069988 3 kidney:3 ENST00000316626 5 splice site 0.0 0.0 0.0 3.0 3.0 0.0 0.0 0.0 1.0 RB1 X605 X:7 605 sp:7 0.000771125042778052 0.000771125042778052 1 7 lung:2|bladder:2|prostate:1|brain:1|breast:1 ENST00000267163 4 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 CIC S231 S:4 231 G:1|I:1|N:2 0.000799845943361296 0.596762494793733 0.000799845943361296 4 brain:4 ENST00000575354 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FAT1 R1627 R:12 1627 Q:5|*:7 0.000802593850312719 0.000802593850312719 0.780459781048121 12 uterus:4|pancreas:1|bowel:2|skin:1|stomach:1|head_neck:3 ENST00000441802 2 single residue 5.0 7.0 0.0 0.0 12.0 0.4166666666666667 0.5833333333333334 0.0 0.0 SOCS1 A3 A:6 3 P:1|R:1|T:3|E:1 0.000842046934360504 0.0238039849640606 0.000842046934360504 6 lymph:6 ENST00000332029 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 AKT1 Q79 Q:6 79 K:6 0.000879321560858086 0.000879321560858086 0.154421586287026 6 uterus:2|prostate:2|breast:2 ENST00000349310 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 VHL I151 I:6 151 S:1|T:2|F:1|N:2 0.000898333934521553 0.00376946792753272 0.000898333934521553 6 kidney:6 ENST00000256474 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 U2AF1 I24 I:5 24 T:4|V:1 0.000965907644734733 0.000965907644734733 1 5 unk:1|uterus:1|adrenal_gland:1|pancreas:1|stomach:1 ENST00000291552 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 BCL2 K22 K:10 22 R:1|*:1|K:8 0.0009664695729283 0.0009664695729283 0.000997377797471669 10 lymph:9|head_neck:1 ENST00000333681 4 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 PIK3CA M1004 M:9 1004 V:1|I:8 0.000967541604830105 0.000967541604830105 1 9 lung:1|uterus:2|bladder:1|bowel:1|breast:3|head_neck:1 ENST00000263967 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 ASXL2 M1 M:6 1 T:5|I:1 0.000968286986342165 0.000968286986342165 0.017706356769898 6 bowel:3|skin:1|stomach:2 ENST00000435504 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ALK F1245 F:3 1245 V:1|I:2 0.000975062354863964 1 0.000975062354863964 3 brain:3 ENST00000389048 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PTEN Y155 Y:5 155 C:4|H:1 0.00100344772445177 0.00100344772445177 0.00183132404023244 5 uterus:4|biliary_tract:1 ENST00000371953 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 HNF1A G288 G:3 288 G:3 0.00100775596981065 1 0.00100775596981065 3 lymph:3 ENST00000257555 6 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 FBXW7 R224 R:10 224 Q:5|*:5 0.00102350502188112 0.00102350502188112 1 10 lung:1|cervix:1|uterus:3|thyroid:1|bowel:3|penis:1 ENST00000281708 4 single residue 5.0 5.0 0.0 0.0 10.0 0.5 0.5 0.0 0.0 TP53 N131 N:13 131 S:3|I:8|K:1|N:1 0.00103631572883874 0.00103631572883874 0.0246947491858993 13 lung:6|liver:1|pancreas:2|skin:1|bowel:1|prostate:1|brain:1 ENST00000269305 4 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 TP53 L265 L:19 265 P:8|R:4|L:6|M:1 0.00103631572883874 0.00103631572883874 0.786796638776716 19 lung:1|ovary:1|unk:2|pancreas:2|bladder:1|bowel:2|prostate:2|brain:3|breast:2|head_neck:3 ENST00000269305 4 single residue 19.0 0.0 0.0 0.0 19.0 1.0 0.0 0.0 0.0 CUL3 M299 M:5 299 R:4|V:1 0.00104496519960921 0.0535533570913715 0.00104496519960921 5 prostate:3|stomach:1|brain:1 ENST00000264414 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CHEK2 R346 R:8 346 C:3|S:2|G:2|H:1 0.00106946994093738 0.00106946994093738 0.634048916526404 8 lung:3|ovary:1|bowel:1|soft_tissue:1|breast:1|head_neck:1 ENST00000328354 6 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PIK3CA E39 E:6 39 G:1|K:5 0.00110112193556633 0.0131482982351907 0.00110112193556633 6 uterus:4|brain:1|breast:1 ENST00000263967 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 STK11 H174 H:6 174 R:1|D:1|H:2|Y:1|L:1 0.00114520467593057 0.0051573608933973 0.00114520467593057 6 lung:3|kidney:3 ENST00000326873 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 EGFR A750 A:4 750 P:2|A:2 0.00114853660633903 0.293655448520564 0.00114853660633903 4 lung:4 ENST00000275493 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FBXW7 T532 T:3 532 P:2|I:1 0.00116715416078893 0.0965390630160916 0.00116715416078893 3 bladder:3 ENST00000281708 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 CREBBP D1435 D:9 1435 G:3|H:2|Y:2|N:2 0.00117499563003119 0.00117499563003119 0.139592480261298 9 lung:3|lymph:1|ovary:1|bladder:4 ENST00000262367 5 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SRSF2 P95 P:6 95 R:1|H:2|L:3 0.00121973194958252 0.0504276062532549 0.00121973194958252 6 lymph:1|skin:1|stomach:1|blood:3 ENST00000359995 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 VHL C162 C:8 162 R:2|F:1|W:1|Y:3|*:1 0.00122944432376974 0.00191602439363022 0.00122944432376974 8 kidney:7|pancreas:1 ENST00000256474 2 single residue 7.0 1.0 0.0 0.0 8.0 0.875 0.125 0.0 0.0 CARD11 K215 K:5 215 T:3|M:1|N:1 0.0013161682155681 1 0.0013161682155681 5 lymph:4|uterus:1 ENST00000396946 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 DIS3 R780 R:6 780 S:1|T:2|G:1|K:2 0.00133003215812735 0.0277929652153457 0.00133003215812735 6 kidney:1|thyroid:1|blood:4 ENST00000377767 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PDPK1 P499 P:5 499 S:3|L:2 0.00133636572478297 1 0.00133636572478297 5 skin:5 ENST00000342085 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PIK3CA C604 C:5 604 R:5 0.00134821997922493 0.00134821997922493 0.497825462573124 5 uterus:2|pancreas:1|bowel:1|head_neck:1 ENST00000263967 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 FOXA1 Y259 Y:5 259 C:2|S:2|F:1 0.00135085457803862 0.00135085457803862 0.318442711235488 5 skin:1|prostate:2|breast:2 ENST00000250448 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN X342 X:8 342 sp:8 0.00142850248666773 0.00142850248666773 0.0340548545434857 8 uterus:1|skin:2|brain:5 ENST00000371953 3 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 STK11 N181 N:4 181 S:1|T:1|I:1|Y:1 0.001605169956216 0.00563851894073455 0.001605169956216 4 lung:4 ENST00000326873 7 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PTEN M35 M:8 35 V:3|I:4|L:1 0.00168869830239239 0.00168869830239239 0.716095072074761 8 lung:1|kidney:1|biliary_tract:1|bowel:2|brain:3 ENST00000371953 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 MYC T73 T:6 73 P:2|A:1|I:3 0.00170415109295424 0.00170415109295424 0.378404356996213 6 lung:1|lymph:3|stomach:1|brain:1 ENST00000377970 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CDH1 D288 D:5 288 V:4|N:1 0.0017736054696059 0.793464684608244 0.0017736054696059 5 stomach:4|breast:1 ENST00000261769 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 DNMT3B V229 V:7 229 V:3|L:1|M:3 0.00184129930922227 0.00380273343389245 0.00184129930922227 7 lung:4|uterus:1|breast:2 ENST00000328111 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERCC2 Y14 Y:3 14 C:3 0.00185831947498718 0.0743478510224761 0.00185831947498718 3 bladder:3 ENST00000391945 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 FOXP1 R514 R:9 514 C:3|H:6 0.00189103885682882 0.00189103885682882 0.0595959332573194 9 bladder:3|bowel:4|soft_tissue:1|breast:1 ENST00000318789 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 KRAS Q22 Q:6 22 H:1|K:5 0.0019130164353186 0.0019130164353186 0.0815948272243927 6 lung:1|lymph:1|bowel:3|blood:1 ENST00000311936 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RICTOR S1101 S:10 1101 S:1|L:9 0.00198059525742831 0.00198059525742831 0.195687591223713 10 ovary:1|uterus:2|unk:1|skin:4|penis:1|brain:1 ENST00000357387 3 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 PTPRT L695 L:9 695 R:1|F:6|L:2 0.0020269285120102 1 0.0020269285120102 9 skin:8|bowel:1 ENST00000373198 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 TP53 G262 G:17 262 V:17 0.00203376888510967 0.00203376888510967 0.01238110168909 17 lung:2|ovary:3|lymph:1|uterus:4|bowel:1|skin:1|stomach:1|prostate:1|breast:2|head_neck:1 ENST00000269305 4 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 EIF1AX G6 G:7 6 R:1|C:1|S:1|D:4 0.00204928105723417 0.00204928105723417 1 7 eye:2|lung:2|thymus:1|unk:1|soft_tissue:1 ENST00000379607 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PTEN S170 S:8 170 G:1|I:1|N:6 0.00205793039150722 0.00205793039150722 0.312085923410691 8 lung:1|kidney:1|ovary:1|uterus:1|brain:4 ENST00000371953 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 FOXA1 S242 S:5 242 C:3|F:1|Y:1 0.00206253182693294 0.930381044088368 0.00206253182693294 5 breast:5 ENST00000250448 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 DNAJB1 L190 L:4 190 L:4 0.00208705078434093 0.00208705078434093 1 4 lymph:1|prostate:1|brain:1|head_neck:1 ENST00000254322 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 F113 F:17 113 P:1|C:6|S:2|V:6|F:1|L:1 0.00211656002293528 0.00211656002293528 0.00413023084471847 17 lung:1|lymph:1|liver:1|bowel:2|skin:1|stomach:2|prostate:1|brain:1|breast:7 ENST00000269305 4 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 RAD50 D69 D:6 69 Y:4|N:2 0.00212729720788355 0.180609592917161 0.00212729720788355 6 lung:4|bladder:1|bowel:1 ENST00000265335 6 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 GNAS R160 R:9 160 P:1|C:7|H:1 0.00218412256499689 0.00218412256499689 1 9 lung:1|uterus:1|pancreas:1|bowel:2|stomach:2|prostate:1|breast:1 ENST00000371085 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 FGFR4 N535 N:3 535 K:3 0.00224497777269147 1 0.00224497777269147 3 breast:3 ENST00000292408 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PPP6C S270 S:7 270 L:7 0.00226807160027759 0.344011542793984 0.00226807160027759 7 skin:6|head_neck:1 ENST00000373547 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CA P471 P:7 471 A:2|L:5 0.0022910753942165 0.0022910753942165 1 7 uterus:1|liver:1|bladder:1|bowel:1|skin:1|brain:1|breast:1 ENST00000263967 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CREBBP Y1450 Y:5 1450 C:1|D:2|N:2 0.00236925569277985 0.00236925569277985 0.183860573209734 5 lung:1|lymph:2|head_neck:2 ENST00000262367 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 RB1 X89 X:8 89 sp:8 0.00238216671696255 0.0154782036383753 0.00238216671696255 8 lung:7|brain:1 ENST00000267163 4 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 KMT2D L1375 L:3 1375 I:1|L:2 0.00240632662871761 1 0.00240632662871761 3 kidney:3 ENST00000301067 7 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 ERCC2 P463 P:6 463 Q:1|S:1|L:4 0.00240750708339393 0.00879909905102043 0.00240750708339393 6 kidney:1|liver:1|bladder:4 ENST00000391945 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CYSLTR2 L129 L:3 129 Q:3 0.00248880623374966 1 0.00248880623374966 3 eye:3 ENST00000282018 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 IL7R I241 I:5 241 V:2|F:1|L:1|M:1 0.00254942980031351 0.847778347150674 0.00254942980031351 5 lung:5 ENST00000303115 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 SMARCA4 R1135 R:9 1135 Q:4|W:5 0.00257748951777747 0.00257748951777747 0.142909285072296 9 lymph:1|bladder:3|stomach:2|brain:2|head_neck:1 ENST00000358026 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 KEAP1 G480 G:9 480 V:1|W:7|G:1 0.00262221927300804 0.0629328232981732 0.00262221927300804 9 lung:8|skin:1 ENST00000171111 5 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 VHL G114 G:7 114 A:4|R:2|C:1 0.00271531464293943 0.0146112140240486 0.00271531464293943 7 kidney:7 ENST00000256474 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MAP3K1 L380 L:3 380 S:3 0.00275840785948893 0.152375594504344 0.00275840785948893 3 breast:3 ENST00000399503 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PDGFRA N659 N:6 659 S:1|Y:1|K:4 0.00278269713630747 0.0558778800969575 0.00278269713630747 6 soft_tissue:2|brain:4 ENST00000257290 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ERCC2 D609 D:3 609 E:2|G:1 0.00281270456279724 0.12939243634002 0.00281270456279724 3 bladder:3 ENST00000391945 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 ERCC2 E606 E:6 606 Q:4|G:2 0.00281270456279724 0.0857258415044585 0.00281270456279724 6 bladder:5|prostate:1 ENST00000391945 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PIK3CA D939 D:4 939 G:4 0.00289242577603165 0.00289242577603165 0.202567006817592 4 uterus:2|breast:2 ENST00000263967 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 MAP2K1 Q56 Q:5 56 P:5 0.00292307151816356 0.00292307151816356 1 5 lung:2|uterus:1|bowel:2 ENST00000307102 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CDH1 X722 X:4 722 sp:4 0.00296596686937428 0.179300358586825 0.00296596686937428 4 breast:4 ENST00000261769 5 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 CIC N205 N:3 205 S:3 0.00300209188506545 0.573265958548127 0.00300209188506545 3 brain:3 ENST00000575354 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 KDM6A X1293 X:5 1293 sp:5 0.00305903400488818 0.00305903400488818 1 5 lung:1|bladder:2|skin:1|stomach:1 ENST00000377967 4 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 SOX17 A96 A:4 96 G:4 0.0031058778949461 1 0.0031058778949461 4 cervix:1|uterus:3 ENST00000297316 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SMAD4 L536 L:4 536 P:2|Q:1|R:1 0.00311073967452292 0.00311073967452292 0.418549549927651 4 pancreas:2|bowel:2 ENST00000342988 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PIK3CA T1052 T:5 1052 K:5 0.00312237313750376 0.00312237313750376 0.498470543667972 5 liver:1|bowel:2|stomach:2 ENST00000263967 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN Y178 Y:5 178 C:1|H:1|*:3 0.00335970330625585 0.00335970330625585 0.110182529828604 5 lung:1|skin:2|brain:2 ENST00000371953 3 single residue 2.0 3.0 0.0 0.0 5.0 0.4 0.6 0.0 0.0 KEAP1 M110 M:6 110 V:3|I:3 0.00338070344003822 0.0522547519433849 0.00338070344003822 6 lung:6 ENST00000171111 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 KEAP1 R272 R:8 272 P:2|C:3|H:2|L:1 0.00338070344003822 0.0225766355204872 0.00338070344003822 8 lung:7|head_neck:1 ENST00000171111 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 GATA3 R364 R:5 364 S:2|T:2|G:1 0.00354740691184041 1 0.00354740691184041 5 breast:5 ENST00000346208 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 JUN E112 E:7 112 Q:2|K:5 0.00366249429213643 0.00905791202106515 0.00366249429213643 7 lung:2|bladder:4|breast:1 ENST00000371222 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CTCF S354 S:10 354 F:9|Y:1 0.00367325788101451 0.00367325788101451 1 10 biliary_tract:1|uterus:1|bladder:3|skin:3|blood:1|head_neck:1 ENST00000264010 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 ARID2 R314 R:9 314 C:8|S:1 0.00383083238325229 0.144413286758459 0.00383083238325229 9 unk:1|pancreas:1|skin:6|bowel:1 ENST00000334344 6 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 MED12 V1223 V:3 1223 V:1|L:2 0.00387330885595878 1 0.00387330885595878 3 prostate:3 ENST00000374080 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 KLF4 K409 K:7 409 Q:5|N:2 0.0040215756215764 0.0040215756215764 0.0704030396662525 7 pancreas:2|bladder:1|prostate:1|brain:1|breast:2 ENST00000374672 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 STK11 E165 E:9 165 Q:2|*:6|K:1 0.00404178594646078 0.00404178594646078 0.0458183301736304 9 lung:6|unk:1|breast:2 ENST00000326873 7 single residue 3.0 6.0 0.0 0.0 9.0 0.3333333333333333 0.6666666666666666 0.0 0.0 AKT3 E17 E:10 17 *:1|K:9 0.00407836413892336 0.00407836413892336 0.45507602167766 10 kidney:1|bladder:1|skin:3|soft_tissue:2|penis:1|prostate:1|brain:1 ENST00000263826 5 single residue 9.0 1.0 0.0 0.0 10.0 0.9 0.1 0.0 0.0 CARD11 L251 L:3 251 P:3 0.00409188109411549 1 0.00409188109411549 3 lymph:3 ENST00000396946 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 STK11 P221 P:8 221 P:1|S:1|L:6 0.00419615615814037 0.00419615615814037 1 8 lung:2|kidney:1|unk:1|bladder:1|bowel:1|stomach:1|breast:1 ENST00000326873 7 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 TP53 L111 L:18 111 P:7|Q:4|R:6|M:1 0.00420150034956331 0.00420150034956331 0.601958957595958 18 lung:2|liver:3|adrenal_gland:1|bladder:1|bowel:1|skin:1|stomach:2|prostate:1|brain:2|breast:3|blood:1 ENST00000269305 4 single residue 18.0 0.0 0.0 0.0 18.0 1.0 0.0 0.0 0.0 SESN2 I425 I:2 425 V:2 0.00451586263584824 1 0.00451586263584824 2 bladder:2 ENST00000253063 3 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 MAP2K4 S184 S:9 184 S:1|W:1|L:7 0.00461638383133961 0.00952164443695222 0.00461638383133961 9 stomach:1|brain:1|breast:6|head_neck:1 ENST00000353533 5 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SMARCA4 R973 R:10 973 Q:5|W:5 0.00471444398662183 0.00471444398662183 0.0170960350250536 10 cervix:1|lymph:3|thymus:1|uterus:1|bowel:2|stomach:2 ENST00000358026 2 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 ERBB2 G660 G:5 660 R:1|D:3|G:1 0.00493020193582609 0.00493020193582609 0.0190512524896 5 cervix:1|uterus:1|bladder:3 ENST00000269571 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 NCOA3 R80 R:3 80 C:2|H:1 0.00503087688152371 1 0.00503087688152371 3 bladder:3 ENST00000371998 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 FOXA1 D226 D:9 226 G:4|N:5 0.00504815371636297 0.00555369306953051 0.00504815371636297 9 bladder:1|prostate:3|breast:5 ENST00000250448 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 FOXP1 X511 X:11 511 sp:11 0.00505681355917067 0.0298637297080324 0.00505681355917067 11 lung:2|bladder:4|breast:5 ENST00000318789 4 splice site 0.0 0.0 0.0 11.0 11.0 0.0 0.0 0.0 1.0 PIK3R1 K379 K:4 379 E:2|N:2 0.0051280355068743 0.0299513674616502 0.0051280355068743 4 soft_tissue:1|brain:3 ENST00000274335 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ERBB2 R103 R:6 103 Q:6 0.00522897959822954 0.197151952021602 0.00522897959822954 6 pancreas:1|bladder:5 ENST00000269571 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PIM1 K24 K:7 24 K:3|N:4 0.00528607615357521 0.0793968564424058 0.00528607615357521 7 lymph:7 ENST00000373509 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PTEN D24 D:10 24 E:2|V:2|G:3|H:2|N:1 0.00530937503240004 0.00530937503240004 1 10 kidney:2|uterus:2|thyroid:1|stomach:2|soft_tissue:1|breast:2 ENST00000371953 3 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 KRAS D33 D:4 33 E:4 0.00545510994623059 0.00545510994623059 0.339919563188649 4 lung:1|bowel:2|testis:1 ENST00000311936 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PTEN P38 P:11 38 S:7|F:1|L:3 0.00565128852492496 1 0.00565128852492496 11 kidney:1|uterus:1|skin:9 ENST00000371953 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 AXL A273 A:4 273 P:1|V:3 0.0057559976089476 1 0.0057559976089476 4 bladder:3|bowel:1 ENST00000301178 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KDR R1032 R:12 1032 Q:8|*:4 0.00584924439117527 0.00584924439117527 0.615206240101299 12 unk:1|uterus:1|skin:5|bowel:3|prostate:1|brain:1 ENST00000263923 4 single residue 8.0 4.0 0.0 0.0 12.0 0.6666666666666666 0.3333333333333333 0.0 0.0 KDR S1037 S:11 1037 S:6|T:1|L:4 0.00584924439117527 0.00584924439117527 1 11 lung:1|thyroid:1|pancreas:1|bowel:2|skin:4|stomach:1|brain:1 ENST00000263923 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 TP53 D259 D:31 259 D:1|V:7|H:2|Y:19|N:2 0.00592807649110612 0.00592807649110612 0.681069104037749 31 lung:5|kidney:1|ovary:4|biliary_tract:2|liver:1|pancreas:3|adrenal_gland:1|bladder:5|bowel:5|skin:1|soft_tissue:1|head_neck:2 ENST00000269305 4 single residue 31.0 0.0 0.0 0.0 31.0 1.0 0.0 0.0 0.0 GNA11 R183 R:7 183 R:1|C:5|H:1 0.00595910002721709 0.00595910002721709 1 7 eye:1|lung:1|adrenal_gland:1|skin:2|prostate:1|breast:1 ENST00000078429 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CDKN2A P48 P:12 48 R:2|L:10 0.00610553972408702 0.00610553972408702 0.0222862241725521 12 pancreas:2|skin:6|stomach:1|soft_tissue:1|brain:1|head_neck:1 ENST00000579755 1 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 RB1 X776 X:6 776 sp:6 0.00618941093976789 0.00618941093976789 1 6 lung:2|pancreas:1|bladder:1|bowel:1|prostate:1 ENST00000267163 4 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 DIS3 D479 D:5 479 V:1|G:1|H:1|Y:2 0.00626223765902431 0.582059206526224 0.00626223765902431 5 lung:4|breast:1 ENST00000377767 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PIK3CA H1065 H:5 1065 Y:4|L:1 0.00632321990539015 0.00632321990539015 1 5 lung:1|kidney:1|bladder:1|bowel:1|breast:1 ENST00000263967 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PIK3R1 D560 D:8 560 G:3|H:2|Y:2|N:1 0.00650808905211078 0.00650808905211078 0.0128714877599463 8 lung:1|lymph:1|bowel:1|brain:3|head_neck:1|breast:1 ENST00000274335 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 TP63 E609 E:11 609 K:11 0.00654115661493069 0.21991304469231 0.00654115661493069 11 unk:1|uterus:1|skin:9 ENST00000264731 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 TP53 I251 I:15 251 S:3|F:5|I:1|M:1|N:5 0.00655470239847348 0.00655470239847348 0.285598510519321 15 lung:1|ovary:3|pancreas:2|bowel:1|skin:1|stomach:1|prostate:1|soft_tissue:1|breast:1|head_neck:3 ENST00000269305 4 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 PIK3CA G364 G:6 364 A:1|R:5 0.00666202370596311 0.00666202370596311 1 6 lung:1|uterus:1|bladder:1|bowel:2|breast:1 ENST00000263967 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CDKN2A N42 N:5 42 H:2|I:1|Y:1|K:1 0.00666274404041663 0.00666274404041663 1 5 lung:1|unk:1|pancreas:1|stomach:1|head_neck:1 ENST00000579755 1 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 DIS3 R689 R:9 689 Q:8|G:1 0.00674087265617022 0.00674087265617022 0.0914584776400131 9 uterus:1|bowel:5|prostate:1|blood:1|breast:1 ENST00000377767 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 DIS3 L767 L:4 767 F:4 0.00674087265617022 0.00674087265617022 1 4 lung:1|liver:1|bladder:1|brain:1 ENST00000377767 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 DIS3 R382 R:9 382 Q:8|G:1 0.00674087265617022 0.00674087265617022 1 9 uterus:2|thyroid:1|bladder:1|bowel:3|stomach:1|prostate:1 ENST00000377767 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 H3C2 E51 E:12 51 Q:3|D:2|E:3|K:4 0.00676671353335492 0.00676671353335492 1 12 lung:3|ovary:1|unk:1|bladder:2|skin:2|stomach:1|breast:2 ENST00000244661 2 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 PTEN Y16 Y:5 16 D:1|Y:1|*:3 0.00677821009113384 0.00677821009113384 1 5 lung:1|uterus:2|bowel:1|brain:1 ENST00000371953 3 single residue 2.0 3.0 0.0 0.0 5.0 0.4 0.6 0.0 0.0 GLI1 R380 R:8 380 Q:6|R:1|*:1 0.0067835673540912 0.414070138865 0.0067835673540912 8 lung:2|uterus:1|bowel:5 ENST00000228682 2 single residue 7.0 1.0 0.0 0.0 8.0 0.875 0.125 0.0 0.0 ATM L2890 L:5 2890 P:2|R:1|V:1|I:1 0.0068729555794163 0.0068729555794163 1 5 lung:1|unk:1|bladder:1|skin:1|stomach:1 ENST00000278616 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 JAK1 L910 L:3 910 P:1|S:1|L:1 0.00697986479202836 1 0.00697986479202836 3 liver:3 ENST00000342505 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 EGFR L838 L:3 838 P:1|M:2 0.00715263397573601 1 0.00715263397573601 3 kidney:3 ENST00000275493 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 RAC1 Q61 Q:4 61 R:2|K:2 0.00720141225078055 0.00720141225078055 1 4 unk:2|prostate:1|testis:1 ENST00000356142 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 EIF1AX P2 P:7 2 P:1|S:2|L:4 0.0072542682644841 0.0072542682644841 1 7 eye:1|lung:1|unk:2|uterus:1|skin:1|soft_tissue:1 ENST00000379607 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 VHL H115 H:7 115 Q:1|Y:2|N:4 0.00743191624202421 0.0402654309163561 0.00743191624202421 7 kidney:7 ENST00000256474 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MAP2K4 X297 X:6 297 sp:6 0.00744286485556026 0.00744286485556026 0.0983638794696612 6 lung:1|thyroid:1|stomach:1|breast:3 ENST00000353533 5 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 MAP2K4 R134 R:11 134 Q:1|W:9|L:1 0.00744286485556026 0.00744286485556026 1 11 lung:1|pancreas:2|bowel:4|prostate:1|breast:3 ENST00000353533 5 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 BCL6 R618 R:7 618 C:6|H:1 0.00748624177672911 0.00748624177672911 0.286914925682123 7 lung:1|skin:3|bowel:2|breast:1 ENST00000232014 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERBB2 D277 D:8 277 V:1|G:1|H:2|Y:4 0.00753448990574709 0.112707300097262 0.00753448990574709 8 lung:1|bladder:6|bowel:1 ENST00000269571 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PTEN Y346 Y:6 346 C:1|D:2|H:1|*:2 0.00758644893706279 0.00758644893706279 1 6 lung:1|kidney:1|bowel:1|brain:2|breast:1 ENST00000371953 3 single residue 4.0 2.0 0.0 0.0 6.0 0.6666666666666666 0.3333333333333333 0.0 0.0 PTEN Y177 Y:5 177 C:1|D:1|F:1|*:2 0.00758644893706279 0.00758644893706279 0.110182529828604 5 thyroid:1|bladder:1|skin:2|brain:1 ENST00000371953 3 single residue 3.0 2.0 0.0 0.0 5.0 0.6 0.4 0.0 0.0 B2M L7 L:5 7 S:2|*:3 0.00770415024339667 0.00770415024339667 0.0173916886852703 5 lymph:3|skin:2 ENST00000558401 1 single residue 2.0 3.0 0.0 0.0 5.0 0.4 0.6 0.0 0.0 FBXW7 E287 E:7 287 Q:2|D:2|V:2|K:1 0.00774127307000243 0.00774127307000243 1 7 lung:2|ovary:1|bowel:2|stomach:2 ENST00000281708 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 FOXL2 E118 E:7 118 Q:1|K:6 0.00808298632412623 0.00808298632412623 1 7 lung:2|cervix:1|bladder:2|skin:1|breast:1 ENST00000330315 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 EGFR K754 K:3 754 E:1|I:1|K:1 0.00841607903718246 0.435609997308213 0.00841607903718246 3 lung:3 ENST00000275493 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 TP63 S365 S:12 365 S:3|*:2|L:7 0.00847835763366027 0.00847835763366027 1 12 lung:1|kidney:1|pancreas:1|skin:5|bowel:1|prostate:1|testis:1|brain:1 ENST00000264731 3 single residue 10.0 2.0 0.0 0.0 12.0 0.8333333333333334 0.16666666666666666 0.0 0.0 EPHB1 R743 R:9 743 Q:3|R:2|W:4 0.00851534342722432 0.381490624963661 0.00851534342722432 9 skin:6|prostate:1|stomach:1|brain:1 ENST00000398015 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 PTPN11 N308 N:3 308 S:1|D:2 0.00866741098637617 0.571037613569942 0.00866741098637617 3 brain:3 ENST00000351677 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PTPN11 F285 F:4 285 S:3|V:1 0.00866741098637617 0.0639133064327108 0.00866741098637617 4 brain:3|blood:1 ENST00000351677 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PIK3CA C90 C:4 90 R:1|S:1|G:1|Y:1 0.00868121273346674 0.00868121273346674 0.565210383002144 4 cervix:1|bladder:1|brain:2 ENST00000263967 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SF3B1 D894 D:6 894 A:1|G:2|Y:1|N:2 0.00868422598732493 0.0163295740042995 0.00868422598732493 6 kidney:1|skin:2|blood:3 ENST00000335508 6 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SDHA V644 V:7 644 L:1|M:6 0.00891411211670894 0.00891411211670894 0.059044839317596 7 lung:2|lymph:3|brain:1|head_neck:1 ENST00000264932 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIM1 Q37 Q:5 37 Q:2|H:3 0.00912235538516294 0.0793968564424058 0.00912235538516294 5 lymph:5 ENST00000373509 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 RIT1 M90 M:11 90 I:11 0.00949362579637069 0.00949362579637069 0.549270631832918 11 lung:3|cervix:1|biliary_tract:1|bladder:4|blood:1|breast:1 ENST00000368323 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ERBB2 T862 T:4 862 A:4 0.00960995949933103 0.00960995949933103 0.180429317763848 4 bladder:2|stomach:1|breast:1 ENST00000269571 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SMAD4 D493 D:7 493 A:1|G:2|H:1|N:3 0.00966195161579594 0.00966195161579594 0.877594038794001 7 lung:3|biliary_tract:1|bowel:2|prostate:1 ENST00000342988 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MTOR A1971 A:6 1971 P:1|S:1|T:4 0.00966713792920051 0.00966713792920051 1 6 kidney:1|liver:1|bladder:1|prostate:1|brain:1|blood:1 ENST00000361445 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 HLA-B E69 E:5 69 A:3|K:2 0.00998841609209048 1 0.00998841609209048 5 lymph:4|bowel:1 ENST00000412585 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN W111 W:9 111 R:1|S:1|G:1|*:6 0.0100439635759994 0.0100439635759994 1 9 lung:2|lymph:1|uterus:1|thyroid:1|bowel:1|skin:1|prostate:1|brain:1 ENST00000371953 3 single residue 3.0 6.0 0.0 0.0 9.0 0.3333333333333333 0.6666666666666666 0.0 0.0 PTEN C71 C:7 71 F:1|Y:5|*:1 0.0100439635759994 0.0100439635759994 0.0677873512467778 7 kidney:1|uterus:1|brain:5 ENST00000371953 3 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 TNFRSF14 M1 M:4 1 T:1|I:2|K:1 0.0100655869328098 0.239632291052043 0.0100655869328098 4 lymph:4 ENST00000355716 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 H3C2 E106 E:14 106 Q:5|E:1|K:8 0.0101928202808917 0.0101928202808917 0.0435606763534294 14 lung:6|bladder:1|skin:4|prostate:1|head_neck:1|breast:1 ENST00000244661 2 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 EGFR L833 L:5 833 F:2|V:2|M:1 0.0101972498092972 0.204421107108247 0.0101972498092972 5 lung:4|breast:1 ENST00000275493 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 FOXO1 T24 T:3 24 I:2|M:1 0.0102244267593044 1 0.0102244267593044 3 lymph:3 ENST00000379561 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 CDKN2A S12 S:12 12 *:8|L:4 0.0102315474126578 0.0102315474126578 1 12 lung:3|thymus:1|unk:1|bladder:4|skin:1|breast:2 ENST00000579755 1 single residue 4.0 8.0 0.0 0.0 12.0 0.3333333333333333 0.6666666666666666 0.0 0.0 EP300 X1539 X:5 1539 sp:5 0.0102558590758561 0.0102558590758561 0.943142968502577 5 lung:1|bladder:1|bowel:1|stomach:2 ENST00000263253 7 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 CREBBP W1502 W:6 1502 R:1|C:3|*:1|L:1 0.0102805884281454 0.0271719082117251 0.0102805884281454 6 lung:1|lymph:3|bladder:2 ENST00000262367 5 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 ERBB3 F219 F:5 219 C:1|L:4 0.0103410425708807 0.0103410425708807 1 5 cervix:1|uterus:1|bladder:1|stomach:1|head_neck:1 ENST00000267101 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 HLA-A L180 L:7 180 L:7 0.0104831562927601 1 0.0104831562927601 7 lymph:2|bowel:5 ENST00000376809 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CTNNB1 K292 K:4 292 T:1|E:3 0.0105287083300164 0.0105287083300164 1 4 lung:1|biliary_tract:1|skin:1|bowel:1 ENST00000349496 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FOXP1 S448 S:10 448 S:2|L:8 0.0106173709484405 0.0106173709484405 0.0269545112732624 10 uterus:1|skin:5|bowel:4 ENST00000318789 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 MTOR L1460 L:4 1460 P:4 0.0109744673866623 0.527838660576444 0.0109744673866623 4 kidney:3|thyroid:1 ENST00000361445 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KDM6A G526 G:4 526 E:1|V:1|G:1|*:1 0.0113277605529172 1 0.0113277605529172 4 kidney:3|head_neck:1 ENST00000377967 4 single residue 3.0 1.0 0.0 0.0 4.0 0.75 0.25 0.0 0.0 ATM R1466 R:9 1466 P:2|Q:3|*:4 0.0114010066702172 0.0114010066702172 1 9 lung:1|bladder:3|bowel:3|stomach:1|blood:1 ENST00000278616 4 single residue 5.0 4.0 0.0 0.0 9.0 0.5555555555555556 0.4444444444444444 0.0 0.0 CARD11 D357 D:4 357 V:3|N:1 0.0114332958492849 1 0.0114332958492849 4 lung:1|lymph:3 ENST00000396946 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PRDM14 F204 F:6 204 F:5|V:1 0.011513819119626 1 0.011513819119626 6 skin:5|stomach:1 ENST00000276594 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 IGF1R G129 G:3 129 A:1|R:1|G:1 0.011524838515816 1 0.011524838515816 3 breast:3 ENST00000268035 6 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 ERBB4 K1002 K:6 1002 R:1|T:5 0.0116020936023758 1 0.0116020936023758 6 bowel:1|stomach:5 ENST00000342788 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ERBB4 K1223 K:6 1223 R:2|T:3|M:1 0.0116020936023758 1 0.0116020936023758 6 bowel:1|stomach:5 ENST00000342788 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 SMO W535 W:3 535 L:3 0.0116503765899911 1 0.0116503765899911 3 brain:3 ENST00000249373 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 GPS2 X242 X:2 242 sp:2 0.0118955414082871 1 0.0118955414082871 2 liver:2 ENST00000380728 2 splice site 0.0 0.0 0.0 2.0 2.0 0.0 0.0 0.0 1.0 NSD1 F392 F:7 392 F:7 0.0119254817879873 1 0.0119254817879873 7 uterus:2|bowel:5 ENST00000439151 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 RARA F286 F:4 286 S:2|C:1|I:1 0.0121887973685868 0.0121887973685868 0.324190749441954 4 lung:2|skin:1|breast:1 ENST00000254066 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FBXW7 R14 R:9 14 Q:6|*:3 0.0122075449025547 0.0122075449025547 1 9 uterus:2|bladder:2|bowel:4|stomach:1 ENST00000281708 4 single residue 6.0 3.0 0.0 0.0 9.0 0.6666666666666666 0.3333333333333333 0.0 0.0 FBXW7 G437 G:6 437 E:1|V:3|G:1|*:1 0.0122075449025547 0.0122075449025547 1 6 lung:1|uterus:1|bladder:1|bowel:1|stomach:1|blood:1 ENST00000281708 4 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 TP53 D208 D:12 208 E:1|V:7|G:2|N:2 0.0123251218508829 1 0.0123251218508829 12 lung:3|ovary:1|uterus:1|bladder:1|brain:2|breast:4 ENST00000269305 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 PIK3CA P539 P:6 539 R:6 0.0127676568720805 0.0127676568720805 1 6 lung:2|unk:1|pancreas:1|breast:2 ENST00000263967 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 DICER1 D1709 D:10 1709 N:10 0.0129764974536984 0.0129764974536984 0.495318385837941 10 lung:1|uterus:4|bladder:1|bowel:1|skin:1|soft_tissue:1|brain:1 ENST00000393063 1 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 CRLF2 S128 S:7 128 S:3|L:4 0.0130680865115582 0.0130680865115582 1 7 lung:2|skin:3|bowel:1|breast:1 ENST00000400841 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 RIT1 F82 F:4 82 C:1|L:3 0.0131232804958808 0.0131232804958808 0.22356056940042 4 lung:2|skin:1|bowel:1 ENST00000368323 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 MYD88 M232 M:3 232 T:3 0.0134687878326664 0.857227039138853 0.0134687878326664 3 lymph:1|blood:2 ENST00000396334 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PIK3R1 Y452 Y:4 452 C:2|H:1|N:1 0.0137524642529949 0.0137524642529949 0.180539470918764 4 uterus:2|stomach:1|head_neck:1 ENST00000274335 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KEAP1 G333 G:7 333 C:4|S:2|F:1 0.0137807717512058 0.235049744668877 0.0137807717512058 7 lung:7 ENST00000171111 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 BCL2 G33 G:6 33 R:5|G:1 0.0137911686286346 0.0692871398183635 0.0137911686286346 6 lymph:6 ENST00000333681 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 TP53 N247 N:15 247 I:8|N:7 0.0141746189488235 0.453926969434036 0.0141746189488235 15 lung:3|ovary:1|skin:7|stomach:1|soft_tissue:2|breast:1 ENST00000269305 4 single residue 15.0 0.0 0.0 0.0 15.0 1.0 0.0 0.0 0.0 TP53 R181 R:26 181 P:8|C:9|H:9 0.0141746189488235 0.159706532719194 0.0141746189488235 26 lung:7|ovary:1|uterus:1|pancreas:1|bladder:2|skin:3|bowel:3|stomach:2|prostate:2|soft_tissue:1|brain:3 ENST00000269305 4 single residue 26.0 0.0 0.0 0.0 26.0 1.0 0.0 0.0 0.0 RHOA L22 L:5 22 P:1|R:3|L:1 0.0143875675561847 0.0143875675561847 0.0585313476535654 5 pancreas:1|bladder:1|stomach:3 ENST00000418115 1 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 STK11 P179 P:7 179 Q:2|R:2|L:3 0.0144151536030241 0.0144151536030241 1 7 lung:3|cervix:1|pancreas:1|adrenal_gland:1|skin:1 ENST00000326873 7 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ATRX X199 X:4 199 sp:4 0.0145598381914334 1 0.0145598381914334 4 uterus:1|brain:3 ENST00000373344 5 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 STAT3 F384 F:4 384 V:1|Y:1|L:2 0.014884260303677 0.014884260303677 0.189865452300858 4 uterus:2|prostate:1|breast:1 ENST00000264657 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 Y107 Y:15 107 D:6|Y:1|*:8 0.014979632693567 0.014979632693567 0.0424748348894808 15 lung:2|lymph:1|uterus:1|liver:1|bowel:2|skin:1|stomach:1|prostate:1|breast:5 ENST00000269305 4 single residue 7.0 8.0 0.0 0.0 15.0 0.4666666666666667 0.5333333333333333 0.0 0.0 STAT3 D661 D:5 661 V:3|Y:2 0.0151718798921814 0.0151718798921814 0.0340453848705226 5 lymph:1|stomach:1|head_neck:2|blood:1 ENST00000264657 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 KNSTRN P28 P:5 28 S:2|L:3 0.0151833562317312 1 0.0151833562317312 5 skin:5 ENST00000249776 8 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PIK3R1 X475 X:5 475 sp:5 0.0153614035834394 0.0153614035834394 1 5 skin:1|stomach:2|prostate:1|brain:1 ENST00000274335 5 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 EIF1AX K10 K:4 10 T:1|E:3 0.0159902632702165 0.0159902632702165 1 4 bowel:2|skin:1|brain:1 ENST00000379607 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ERBB3 M60 M:4 60 R:1|K:3 0.0162084155769783 0.0162084155769783 1 4 uterus:1|bladder:1|bowel:1|stomach:1 ENST00000267101 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TGFBR2 E544 E:5 544 K:5 0.016266709218872 1 0.016266709218872 5 head_neck:5 ENST00000295754 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 KMT2D R5432 R:8 5432 Q:3|R:1|W:4 0.0163159021207786 0.0163159021207786 1 8 lung:2|skin:3|bowel:1|brain:1|head_neck:1 ENST00000301067 7 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 KEAP1 G417 G:7 417 R:1|E:1|V:4|W:1 0.0163931870611199 0.26130198427535 0.0163931870611199 7 lung:7 ENST00000171111 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MYC V7 V:4 7 M:4 0.0166440841859353 0.222926306296385 0.0166440841859353 4 lymph:4 ENST00000377970 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CREBBP L1499 L:4 1499 P:2|Q:1|R:1 0.0171122100701789 1 0.0171122100701789 4 lymph:3|bowel:1 ENST00000262367 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TRAF7 N520 N:4 520 S:3|Y:1 0.0171380664656178 0.0243586699299873 0.0171380664656178 4 peritoneum:2|bowel:1|soft_tissue:1 ENST00000326181 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CARD11 D401 D:3 401 N:3 0.017237006488171 1 0.017237006488171 3 lymph:3 ENST00000396946 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 TP53 K120 K:9 120 E:5|*:1|M:1|N:2 0.0176054406780031 0.0226569385948903 0.0176054406780031 9 lung:2|skin:1|stomach:1|brain:4|head_neck:1 ENST00000269305 4 single residue 8.0 1.0 0.0 0.0 9.0 0.8888888888888888 0.1111111111111111 0.0 0.0 MYD88 P166 P:4 166 P:1|L:3 0.0177532694963659 1 0.0177532694963659 4 skin:4 ENST00000396334 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PIK3CD C416 C:2 416 R:2 0.0177652807514415 1 0.0177652807514415 2 testis:2 ENST00000377346 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 GNAQ G48 G:3 48 V:1|*:1|L:1 0.0178075460389295 1 0.0178075460389295 3 eye:3 ENST00000286548 4 single residue 2.0 1.0 0.0 0.0 3.0 0.6666666666666666 0.3333333333333333 0.0 0.0 ATM I2888 I:4 2888 T:3|L:1 0.0178317087176485 0.0178317087176485 1 4 lung:1|bladder:1|skin:1|breast:1 ENST00000278616 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PTEN H61 H:6 61 R:4|Y:1|N:1 0.0179437943852943 0.0179437943852943 1 6 lung:1|uterus:1|pancreas:1|brain:2|breast:1 ENST00000371953 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CARD11 E93 E:4 93 Q:1|D:2|K:1 0.0182330764776687 1 0.0182330764776687 4 lymph:3|skin:1 ENST00000396946 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 I254 I:13 254 S:7|V:2|F:1|L:1|M:1|N:1 0.0184452967314114 0.0184452967314114 0.247434779732685 13 lung:3|liver:2|pancreas:2|bowel:3|stomach:1|brain:1|breast:1 ENST00000269305 4 single residue 13.0 0.0 0.0 0.0 13.0 1.0 0.0 0.0 0.0 ERBB3 R103 R:5 103 R:2|G:1|H:2 0.0184874894301309 0.146062887818286 0.0184874894301309 5 uterus:1|bladder:3|bowel:1 ENST00000267101 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CCNQ X141 X:4 141 sp:4 0.0186113922627832 0.0186113922627832 0.844520280898518 4 lung:1|skin:2|breast:1 ENST00000406277 2 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 CDH1 R63 R:8 63 P:1|G:1|*:6 0.0187372466896063 0.0367706527801527 0.0187372466896063 8 bladder:2|brain:1|breast:5 ENST00000261769 5 single residue 2.0 6.0 0.0 0.0 8.0 0.25 0.75 0.0 0.0 PIK3CA E970 E:9 970 K:9 0.0189638488402124 0.0189638488402124 0.423322431084515 9 bladder:1|bowel:2|stomach:1|breast:4|head_neck:1 ENST00000263967 3 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 EP300 Q1455 Q:6 1455 Q:1|R:1|H:4 0.0189801339276453 1 0.0189801339276453 6 bladder:6 ENST00000263253 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 HNF1A S591 S:3 591 S:2|Y:1 0.0197331659963799 1 0.0197331659963799 3 stomach:3 ENST00000257555 6 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 AKT1 D323 D:5 323 G:2|Y:2|N:1 0.0198991094867804 0.0198991094867804 1 5 lung:1|kidney:1|bladder:1|prostate:1|breast:1 ENST00000349310 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 FBXW7 S546 S:9 546 P:1|*:1|L:7 0.0203093632196684 0.889001684606506 0.0203093632196684 9 kidney:1|bladder:6|prostate:1|head_neck:1 ENST00000281708 4 single residue 8.0 1.0 0.0 0.0 9.0 0.8888888888888888 0.1111111111111111 0.0 0.0 ERBB2 R138 R:3 138 Q:2|W:1 0.0204568143885468 0.909181228496194 0.0204568143885468 3 skin:3 ENST00000269571 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 ANKRD11 K369 K:5 369 R:5 0.0204755008151429 0.0204755008151429 0.0768211843195442 5 skin:2|testis:2|brain:1 ENST00000301030 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 MTOR A1459 A:6 1459 P:1|D:4|V:1 0.0209022099858904 0.0209022099858904 0.863806577219553 6 lung:1|kidney:2|bowel:1|soft_tissue:1|brain:1 ENST00000361445 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 GTF2I F641 F:4 641 C:1|F:3 0.0209524305200254 0.729310324500092 0.0209524305200254 4 pancreas:1|skin:3 ENST00000324896 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TGFBR1 T375 T:3 375 R:1|I:1|K:1 0.0210047882793745 1 0.0210047882793745 3 bowel:3 ENST00000374994 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PIK3CB R321 R:9 321 Q:9 0.0210357822915523 0.0210712936007569 0.0210357822915523 9 uterus:1|bowel:5|skin:1|stomach:1|breast:1 ENST00000289153 2 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 ERRFI1 K409 K:3 409 Q:1|N:2 0.0212231821625514 1 0.0212231821625514 3 bowel:3 ENST00000377482 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 INPPL1 R70 R:4 70 H:4 0.0222950140334926 1 0.0222950140334926 4 stomach:4 ENST00000298229 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ARID1B G966 G:4 966 D:4 0.0223082832237321 1 0.0223082832237321 4 pancreas:3|head_neck:1 ENST00000346085 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ERBB2 T733 T:4 733 I:4 0.0223243040785117 0.0223243040785117 0.572079931776315 4 uterus:1|bladder:2|bowel:1 ENST00000269571 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CBFB M1 M:4 1 T:2|I:1|K:1 0.0223684139186518 0.340963079060791 0.0223684139186518 4 breast:4 ENST00000412916 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ETV6 R369 R:9 369 Q:1|R:1|W:6|L:1 0.0227397135597969 0.0261556756129825 0.0227397135597969 9 lung:1|uterus:1|bladder:1|bowel:5|brain:1 ENST00000396373 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 PTPN11 T468 T:7 468 T:1|M:6 0.0231427297174703 0.0231427297174703 0.204491526340597 7 bowel:3|skin:2|stomach:2 ENST00000351677 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 EIF1AX N4 N:4 4 S:2|I:1|Y:1 0.0232127972275248 0.0232127972275248 1 4 eye:1|ovary:1|thymus:1|bowel:1 ENST00000379607 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 EIF1AX X6 X:5 6 sp:5 0.0232127972275248 0.0232127972275248 1 5 eye:1|ovary:1|bowel:2|prostate:1 ENST00000379607 5 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 CDK12 R890 R:5 890 H:5 0.0234944216172339 1 0.0234944216172339 5 bowel:5 ENST00000447079 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 CTLA4 T17 T:5 17 A:5 0.0243721545716862 0.0243721545716862 0.0438614955102547 5 lymph:1|liver:1|pancreas:2|bowel:1 ENST00000302823 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 BCL10 N173 N:2 173 H:2 0.0244964388236978 1 0.0244964388236978 2 pancreas:2 ENST00000370580 1 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 SMO V414 V:3 414 A:1|V:1|G:1 0.024540518150126 1 0.024540518150126 3 lung:1|cervix:2 ENST00000249373 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 LYN I364 I:2 364 L:1|N:1 0.0246336640316435 1 0.0246336640316435 2 bladder:2 ENST00000519728 1 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 MET H1094 H:4 1094 R:1|Y:3 0.0248978857348268 1 0.0248978857348268 4 lung:1|kidney:3 ENST00000397752 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PBRM1 X856 X:4 856 sp:4 0.0256762205674686 1 0.0256762205674686 4 kidney:4 ENST00000394830 3 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 CTNNB1 R535 R:7 535 Q:2|*:5 0.0258177624043666 0.0258177624043666 0.0479471127652147 7 uterus:1|stomach:4|breast:1|head_neck:1 ENST00000349496 5 single residue 2.0 5.0 0.0 0.0 7.0 0.2857142857142857 0.7142857142857143 0.0 0.0 TP53 I232 I:14 232 S:4|T:3|F:3|I:1|N:3 0.0262978898298508 0.159706532719194 0.0262978898298508 14 lung:1|ovary:1|lymph:1|uterus:1|bowel:4|skin:1|prostate:1|brain:1|breast:2|blood:1 ENST00000269305 4 single residue 14.0 0.0 0.0 0.0 14.0 1.0 0.0 0.0 0.0 SMARCD1 R183 R:7 183 Q:5|*:1|L:1 0.0268785172725617 0.0268785172725617 1 7 biliary_tract:1|uterus:2|thyroid:1|bowel:2|skin:1 ENST00000394963 4 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 PIM1 L2 L:6 2 F:5|V:1 0.0269741273167823 0.260920609235067 0.0269741273167823 6 lymph:6 ENST00000373509 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 FOXA1 R219 R:8 219 R:1|C:3|S:3|G:1 0.0270600943919014 0.0270600943919014 0.0522923679377644 8 bowel:2|skin:1|prostate:4|brain:1 ENST00000250448 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PIM1 E79 E:6 79 D:4|E:2 0.0274181876571439 0.269467551421213 0.0274181876571439 6 lymph:6 ENST00000373509 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RAC1 P34 P:5 34 R:3|S:1|H:1 0.0277542866088587 0.128242198954786 0.0277542866088587 5 skin:1|stomach:1|testis:3 ENST00000356142 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 DICER1 S1344 S:7 1344 I:1|L:6 0.0280566878520535 0.0280566878520535 0.347687229956456 7 uterus:2|biliary_tract:1|skin:4 ENST00000393063 1 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 NOTCH1 R365 R:8 365 C:6|S:2 0.0280924657963512 0.0280924657963512 1 8 lung:1|bladder:1|skin:2|stomach:3|brain:1 ENST00000277541 6 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 CDKN2A D74 D:8 74 V:1|G:1|Y:3|N:3 0.0289475395986871 0.0289475395986871 1 8 lung:3|skin:1|stomach:1|breast:1|head_neck:2 ENST00000579755 1 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 DNMT1 E432 E:7 432 K:7 0.0293011171345867 1 0.0293011171345867 7 bladder:1|bowel:5|stomach:1 ENST00000340748 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 MET Y1003 Y:3 1003 C:1|F:1|*:1 0.0296559961244166 1 0.0296559961244166 3 lung:3 ENST00000397752 3 single residue 2.0 1.0 0.0 0.0 3.0 0.6666666666666666 0.3333333333333333 0.0 0.0 AXIN1 X652 X:3 652 sp:3 0.0296833082515064 1 0.0296833082515064 3 liver:3 ENST00000262320 3 splice site 0.0 0.0 0.0 3.0 3.0 0.0 0.0 0.0 1.0 KEAP1 V155 V:5 155 A:1|F:4 0.0299449285971264 0.26130198427535 0.0299449285971264 5 lung:5 ENST00000171111 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 STK11 W239 W:5 239 C:3|S:1|*:1 0.0302867868500955 0.135448215335122 0.0302867868500955 5 lung:5 ENST00000326873 7 single residue 4.0 1.0 0.0 0.0 5.0 0.8 0.2 0.0 0.0 FGFR3 L8 L:4 8 L:4 0.0302990211029827 1 0.0302990211029827 4 lung:3|skin:1 ENST00000260795 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 EPAS1 Y532 Y:2 532 C:2 0.0308917177568844 1 0.0308917177568844 2 adrenal_gland:2 ENST00000263734 3 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 CD79B X185 X:3 185 sp:3 0.031280397627826 1 0.031280397627826 3 lymph:3 ENST00000392795 3 splice site 0.0 0.0 0.0 3.0 3.0 0.0 0.0 0.0 1.0 POLE E18 E:7 18 K:7 0.0316821444512517 0.0316821444512517 0.298333373057533 7 lung:2|bladder:2|breast:3 ENST00000320574 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CARD11 R337 R:5 337 Q:3|*:2 0.0317184527354723 1 0.0317184527354723 5 lymph:3|bowel:1|soft_tissue:1 ENST00000396946 4 single residue 3.0 2.0 0.0 0.0 5.0 0.6 0.4 0.0 0.0 CARD11 E626 E:6 626 Q:1|*:1|K:4 0.0317184527354723 1 0.0317184527354723 6 lung:2|cervix:1|lymph:3 ENST00000396946 4 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 RBM10 X91 X:5 91 sp:5 0.0317436063416975 0.663863349802184 0.0317436063416975 5 lung:5 ENST00000377604 3 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 PTPN11 T507 T:3 507 K:3 0.0318523642648974 1 0.0318523642648974 3 brain:3 ENST00000351677 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PTPN11 D61 D:4 61 Y:3|N:1 0.0318523642648974 0.93013934142643 0.0318523642648974 4 brain:3|blood:1 ENST00000351677 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 NOTCH1 C440 C:5 440 R:1|S:1|F:2|W:1 0.0322228079201374 0.0322228079201374 0.0354105169074645 5 stomach:1|brain:1|head_neck:3 ENST00000277541 6 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 NOTCH1 G310 G:7 310 R:6|E:1 0.0322228079201374 0.0322228079201374 0.492874484408467 7 skin:3|brain:3|head_neck:1 ENST00000277541 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 ERBB3 R475 R:8 475 W:8 0.0325525423143691 0.0325525423143691 1 8 uterus:1|bladder:1|bowel:3|skin:1|stomach:2 ENST00000267101 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SMAD3 R268 R:11 268 C:7|H:4 0.0327038445077706 0.0327038445077706 0.0539262315599496 11 lung:1|uterus:1|pancreas:1|bowel:7|stomach:1 ENST00000327367 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 SMAD3 R287 R:8 287 Q:2|W:6 0.0327038445077706 0.0327038445077706 1 8 pancreas:1|bladder:1|bowel:3|skin:1|stomach:1|breast:1 ENST00000327367 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 HNF1A I27 I:4 27 L:4 0.0328297064281064 0.296653886009132 0.0328297064281064 4 lymph:2|bladder:1|bowel:1 ENST00000257555 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PRDM14 R505 R:6 505 C:2|H:4 0.0330881832795661 1 0.0330881832795661 6 uterus:1|bowel:4|skin:1 ENST00000276594 2 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CDKN1B X159 X:8 159 sp:8 0.0331705164414828 0.0331705164414828 0.105000533993657 8 kidney:2|liver:1|bladder:1|brain:2|breast:2 ENST00000228872 4 splice site 0.0 0.0 0.0 8.0 8.0 0.0 0.0 0.0 1.0 CDKN1B G72 G:6 72 A:1|D:3|G:2 0.0331705164414828 0.0331705164414828 1 6 lymph:1|thyroid:1|bladder:1|bowel:1|stomach:1|prostate:1 ENST00000228872 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ETV6 S284 S:6 284 S:4|F:2 0.0332331004976096 1 0.0332331004976096 6 skin:5|breast:1 ENST00000396373 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CASP8 X243 X:7 243 sp:7 0.0339327707674888 0.0339327707674888 0.964262041309334 7 lung:1|uterus:1|skin:2|head_neck:3 ENST00000358485 4 splice site 0.0 0.0 0.0 7.0 7.0 0.0 0.0 0.0 1.0 MAP2K4 X347 X:5 347 sp:5 0.0340442289468374 0.0340442289468374 1 5 bladder:1|bowel:1|stomach:1|breast:2 ENST00000353533 5 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 SMARCA4 E821 E:8 821 D:1|K:7 0.0348588465012058 0.0348588465012058 0.142909285072296 8 kidney:1|bladder:4|skin:1|testis:1|brain:1 ENST00000358026 2 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 ALK R395 R:7 395 R:1|H:6 0.035124603778631 0.035124603778631 1 7 lung:1|bowel:2|skin:1|stomach:1|soft_tissue:1|head_neck:1 ENST00000389048 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CIC X151 X:6 151 sp:6 0.0353206266313835 0.0353206266313835 0.207829664281097 6 lung:1|lymph:1|stomach:1|brain:3 ENST00000575354 2 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 NOTCH1 E455 E:7 455 E:1|K:6 0.0354105169074645 0.0467304847952665 0.0354105169074645 7 lung:1|skin:1|stomach:1|head_neck:4 ENST00000277541 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 PIK3CA R357 R:7 357 Q:4|G:1|*:1|L:1 0.036188804599893 0.290834692720819 0.036188804599893 7 kidney:1|uterus:1|bowel:5 ENST00000263967 3 single residue 6.0 1.0 0.0 0.0 7.0 0.8571428571428571 0.14285714285714285 0.0 0.0 STK11 G251 G:6 251 R:1|C:2|V:3 0.0363127834198724 0.0363127834198724 0.0670721453473594 6 lung:5|bowel:1 ENST00000326873 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RPTOR R139 R:8 139 H:8 0.0367985047325461 0.0367985047325461 1 8 cervix:1|uterus:2|pancreas:1|bladder:1|bowel:1|skin:1|prostate:1 ENST00000306801 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 SF3B1 Y623 Y:4 623 C:2|S:1|H:1 0.0377723571915572 0.0377723571915572 1 4 liver:1|bone:1|pleura:1|breast:1 ENST00000335508 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 BRCA2 S2303 S:5 2303 S:3|F:2 0.0384535851439601 1 0.0384535851439601 5 skin:5 ENST00000380152 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 RB1 X463 X:5 463 sp:5 0.038464461387127 0.038464461387127 1 5 lung:2|thyroid:1|liver:1|soft_tissue:1 ENST00000267163 4 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 PTPRT R364 R:12 364 Q:6|R:2|*:4 0.0388462009711605 0.0388462009711605 1 12 lung:1|kidney:1|unk:1|uterus:1|skin:5|bowel:1|brain:2 ENST00000373198 4 single residue 8.0 4.0 0.0 0.0 12.0 0.6666666666666666 0.3333333333333333 0.0 0.0 SETD2 H1603 H:5 1603 R:3|Y:2 0.0393590702541361 0.0393590702541361 0.117747642523402 5 skin:3|brain:1|head_neck:1 ENST00000409792 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 MAX R36 R:2 36 W:2 0.039885672997618 1 0.039885672997618 2 blood:2 ENST00000358664 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 AXL T443 T:2 443 T:2 0.0400800119264523 1 0.0400800119264523 2 bladder:2 ENST00000301178 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 RB1 Y606 Y:4 606 C:2|*:2 0.040781933771183 0.040781933771183 0.986079481538143 4 bladder:1|breast:1|head_neck:2 ENST00000267163 4 single residue 2.0 2.0 0.0 0.0 4.0 0.5 0.5 0.0 0.0 SMARCB1 R374 R:8 374 Q:5|W:3 0.0409234978178552 0.0409234978178552 1 8 unk:1|pancreas:1|bowel:2|stomach:2|brain:1|breast:1 ENST00000263121 7 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 CUL3 A20 A:5 20 A:5 0.0414950238120077 1 0.0414950238120077 5 skin:4|brain:1 ENST00000264414 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 BCL10 E178 E:3 178 D:1|E:2 0.0416290007485654 0.914821520436816 0.0416290007485654 3 pancreas:2|prostate:1 ENST00000370580 1 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 KDM6A X1246 X:4 1246 sp:4 0.0416332513899781 0.0416332513899781 1 4 lung:1|cervix:1|bladder:1|head_neck:1 ENST00000377967 4 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 TGFBR1 R487 R:8 487 Q:5|W:3 0.0420025722530218 0.0420025722530218 1 8 lung:1|uterus:1|pancreas:2|bladder:1|bowel:1|skin:1|stomach:1 ENST00000374994 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 PTPN11 A461 A:5 461 T:4|G:1 0.0426694130573166 0.0457794890156586 0.0426694130573166 5 uterus:1|skin:1|brain:3 ENST00000351677 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN G251 G:6 251 A:1|D:1|V:4 0.043019639792546 0.043019639792546 1 6 uterus:2|skin:2|stomach:1|brain:1 ENST00000371953 3 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PTEN T277 T:6 277 A:1|I:3|*:1|N:1 0.043019639792546 0.043019639792546 1 6 ovary:1|uterus:1|bowel:1|brain:3 ENST00000371953 3 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 FGFR2 F276 F:3 276 C:2|I:1 0.0435896107854571 0.490688086996587 0.0435896107854571 3 biliary_tract:2|bladder:1 ENST00000358487 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 STK11 X125 X:5 125 sp:5 0.0436726212124469 0.0436726212124469 1 5 lung:2|unk:1|bladder:1|stomach:1 ENST00000326873 7 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 NSD1 C1710 C:3 1710 S:1|Y:1|*:1 0.0438691837339285 1 0.0438691837339285 3 head_neck:3 ENST00000439151 2 single residue 2.0 1.0 0.0 0.0 3.0 0.6666666666666666 0.3333333333333333 0.0 0.0 SMAD4 A118 A:11 118 V:11 0.0442845520213532 0.0442845520213532 1 11 ampulla_of_vater:1|pancreas:3|bowel:4|stomach:1|breast:1|head_neck:1 ENST00000342988 3 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 CTCF H288 H:3 288 R:1|D:1|Y:1 0.0444979719260984 1 0.0444979719260984 3 breast:3 ENST00000264010 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PIK3R1 X434 X:5 434 sp:5 0.0447131965725729 0.0447131965725729 1 5 ovary:1|skin:1|prostate:1|brain:1|breast:1 ENST00000274335 5 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 VHL L169 L:5 169 P:5 0.0448753895749222 0.121840846214495 0.0448753895749222 5 kidney:5 ENST00000256474 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 KNSTRN C22 C:4 22 S:1|Y:3 0.0449961288692079 0.0449961288692079 1 4 lung:2|skin:1|stomach:1 ENST00000249776 8 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PPP2R1A R182 R:7 182 R:1|W:6 0.0450904673732307 0.0450904673732307 1 7 lung:1|uterus:2|thyroid:1|bladder:1|stomach:1|breast:1 ENST00000322088 6 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 SMAD4 Y353 Y:4 353 C:1|D:1|N:2 0.0453956226948068 0.0453956226948068 1 4 lung:1|biliary_tract:1|prostate:1|stomach:1 ENST00000342988 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SMAD4 Y95 Y:4 95 C:2|H:1|*:1 0.0453956226948068 0.0453956226948068 1 4 lung:2|biliary_tract:1|pancreas:1 ENST00000342988 3 single residue 3.0 1.0 0.0 0.0 4.0 0.75 0.25 0.0 0.0 TCF3 N551 N:2 551 K:2 0.04594352537914 1 0.04594352537914 2 lymph:2 ENST00000344749 5 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 RPS6KA4 R629 R:7 629 R:1|C:4|H:2 0.0462995364318378 0.0462995364318378 1 7 lung:1|skin:3|bowel:2|prostate:1 ENST00000334205 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 RPS6KA4 S236 S:6 236 S:1|L:5 0.0462995364318378 0.0462995364318378 1 6 lung:2|unk:1|bladder:1|bowel:1|skin:1 ENST00000334205 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PTEN L320 L:4 320 S:1|V:1|*:2 0.0469972383599729 0.0469972383599729 1 4 lung:1|uterus:1|biliary_tract:1|prostate:1 ENST00000371953 3 single residue 2.0 2.0 0.0 0.0 4.0 0.5 0.5 0.0 0.0 CREBBP W1472 W:6 1472 R:2|C:2|S:1|G:1 0.0475077738779973 0.0475077738779973 0.601866708885739 6 lung:1|lymph:2|bladder:1|head_neck:2 ENST00000262367 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 CREBBP Y1482 Y:4 1482 C:1|D:1|H:1|N:1 0.0475077738779973 0.0475077738779973 0.183860573209734 4 lymph:2|bladder:2 ENST00000262367 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FH M336 M:2 336 I:1|L:1 0.0475803468275849 1 0.0475803468275849 2 liver:2 ENST00000366560 3 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 NUP93 A733 A:2 733 A:2 0.0475973579366498 1 0.0475973579366498 2 lymph:2 ENST00000308159 5 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 RECQL4 X766 X:6 766 sp:6 0.0477088999412308 1 0.0477088999412308 6 lymph:2|bowel:4 ENST00000428558 2 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 EIF1AX G8 G:6 8 R:5|E:1 0.0479490680133651 0.0479490680133651 1 6 eye:2|cervix:1|ovary:1|thyroid:1|skin:1 ENST00000379607 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RAD52 R396 R:2 396 R:1|H:1 0.0481336856829914 1 0.0481336856829914 2 skin:2 ENST00000358495 3 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 VHL L135 L:4 135 F:2|*:2 0.0482434197400611 0.117149104216964 0.0482434197400611 4 kidney:4 ENST00000256474 2 single residue 2.0 2.0 0.0 0.0 4.0 0.5 0.5 0.0 0.0 HNF1A R114 R:5 114 C:1|H:3|L:1 0.049626346636423 1 0.049626346636423 5 lung:1|uterus:3|bladder:1 ENST00000257555 6 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 HGF G229 G:3 229 A:2|D:1 0.0500918154904944 1 0.0500918154904944 3 cervix:2|brain:1 ENST00000222390 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 HNF1A G338 G:4 338 A:1|G:3 0.0514682162685184 1 0.0514682162685184 4 prostate:3|stomach:1 ENST00000257555 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 P190 P:17 190 R:1|S:1|T:3|L:12 0.0517990181016758 0.243675359720176 0.0517990181016758 17 lung:1|kidney:1|lymph:1|liver:1|pancreas:1|bowel:6|prostate:3|brain:3 ENST00000269305 4 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 KEAP1 R320 R:8 320 P:1|Q:2|W:1|L:3|M:1 0.0522547519433849 0.0522547519433849 0.062764672710965 8 lung:6|thyroid:1|breast:1 ENST00000171111 5 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 FBXW7 X195 X:5 195 sp:5 0.052851995591814 0.052851995591814 0.925413097423944 5 lung:1|bowel:1|stomach:2|head_neck:1 ENST00000281708 4 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 FBXW7 R441 R:7 441 Q:1|W:3|G:2|L:1 0.052851995591814 0.052851995591814 1 7 lung:2|uterus:2|bowel:1|soft_tissue:1|breast:1 ENST00000281708 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 CDKN1A M1 M:4 1 R:1|V:2|I:1 0.0534198544524845 0.648931278950695 0.0534198544524845 4 liver:3|brain:1 ENST00000244741 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KDR C482 C:3 482 R:2|*:1 0.0557974190648336 1 0.0557974190648336 3 lung:1|lymph:2 ENST00000263923 4 single residue 2.0 1.0 0.0 0.0 3.0 0.6666666666666666 0.3333333333333333 0.0 0.0 ERBB3 N126 N:4 126 I:1|K:3 0.0570727711745951 0.0570727711745951 1 4 bladder:1|bowel:1|prostate:1|stomach:1 ENST00000267101 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 TP53 V197 V:17 197 E:3|V:5|G:1|L:5|M:3 0.057198430388418 0.057198430388418 0.428815569129452 17 lung:5|ovary:1|liver:2|pancreas:1|bladder:1|bowel:1|stomach:3|brain:1|breast:2 ENST00000269305 4 single residue 17.0 0.0 0.0 0.0 17.0 1.0 0.0 0.0 0.0 SMAD4 G510 G:6 510 A:1|R:2|E:1|*:2 0.0574589531183325 0.0574589531183325 0.351346721236098 6 lung:1|pancreas:1|bowel:3|stomach:1 ENST00000342988 3 single residue 4.0 2.0 0.0 0.0 6.0 0.6666666666666666 0.3333333333333333 0.0 0.0 TSC1 X797 X:4 797 sp:4 0.0580126611145658 0.0580126611145658 0.901869432813862 4 uterus:2|bladder:1|skin:1 ENST00000298552 3 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 PLK2 L208 L:3 208 P:2|V:1 0.0580752072255424 1 0.0580752072255424 3 stomach:2|breast:1 ENST00000274289 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PTEN X267 X:5 267 sp:5 0.0584505522716062 0.0584505522716062 1 5 lung:1|uterus:1|thyroid:1|bowel:1|brain:1 ENST00000371953 3 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 STK11 W308 W:6 308 C:2|*:1|L:3 0.0593665276447652 0.0593665276447652 0.0913222881288761 6 lung:5|biliary_tract:1 ENST00000326873 7 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 TP53 M133 M:10 133 R:3|T:1|I:1|K:5 0.0598449339561851 0.0598449339561851 0.0703741415088608 10 lung:1|pancreas:1|skin:1|bowel:1|stomach:1|breast:4|head_neck:1 ENST00000269305 4 single residue 10.0 0.0 0.0 0.0 10.0 1.0 0.0 0.0 0.0 KRAS K5 K:3 5 E:3 0.060055464862559 0.060055464862559 1 3 bowel:1|brain:1|blood:1 ENST00000311936 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 NF1 R1849 R:8 1870 Q:7|W:1 0.0602895567764422 0.0602895567764422 0.449599355746596 8 uterus:1|skin:3|bowel:1|stomach:1|brain:2 ENST00000356175 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 EPHA7 G656 G:11 656 R:1|E:6|G:3|W:1 0.0608812153658397 1 0.0608812153658397 11 skin:9|brain:1|head_neck:1 ENST00000369303 4 single residue 11.0 0.0 0.0 0.0 11.0 1.0 0.0 0.0 0.0 ERBB2 V697 V:4 697 L:4 0.0611219878744376 0.0611219878744376 1 4 unk:1|uterus:1|bowel:1|breast:1 ENST00000269571 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PTPRS Y398 Y:4 398 Y:4 0.0611495944281989 1 0.0611495944281989 4 uterus:1|pancreas:3 ENST00000357368 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 H3C10 K37 K:4 37 E:1|M:3 0.0613363986989126 0.0613363986989126 1 4 lung:1|bladder:1|skin:1|head_neck:1 ENST00000369163 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KEAP1 R601 R:6 601 W:2|L:4 0.0615590624356438 0.674252922493193 0.0615590624356438 6 lung:6 ENST00000171111 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 RAD51C Y224 Y:2 224 H:2 0.0615844369795179 1 0.0615844369795179 2 bladder:2 ENST00000337432 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 RAD51C P21 P:4 21 A:1|S:2|T:1 0.0616334079268701 1 0.0616334079268701 4 bladder:1|breast:3 ENST00000337432 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 BCL2L11 G156 G:6 156 R:3|E:2|*:1 0.061848349524064 0.061848349524064 0.471463300677822 6 lung:1|cervix:1|unk:1|uterus:2|stomach:1 ENST00000393256 3 single residue 5.0 1.0 0.0 0.0 6.0 0.8333333333333334 0.16666666666666666 0.0 0.0 EZH2 K665 K:2 665 R:1|E:1 0.0620628563514022 1 0.0620628563514022 2 lymph:2 ENST00000320356 2 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 MAP2K4 R110 R:8 110 P:1|Q:2|*:4|L:1 0.0625969845163816 0.0625969845163816 1 8 lung:1|ovary:1|uterus:2|thyroid:1|pancreas:1|stomach:1|breast:1 ENST00000353533 5 single residue 4.0 4.0 0.0 0.0 8.0 0.5 0.5 0.0 0.0 TP53 H178 H:12 178 P:3|Q:2|D:5|H:1|N:1 0.0627913608262321 0.282074024405492 0.0627913608262321 12 kidney:1|ovary:2|unk:2|uterus:3|biliary_tract:1|skin:1|brain:2 ENST00000269305 4 single residue 12.0 0.0 0.0 0.0 12.0 1.0 0.0 0.0 0.0 SPRED1 R349 R:2 349 S:1|W:1 0.0638652407183754 1 0.0638652407183754 2 bladder:2 ENST00000299084 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 TP53 V218 V:9 218 E:1|V:1|G:5|L:1|M:1 0.0643906580986468 0.0643906580986468 0.208800626905013 9 lung:1|lymph:1|unk:1|bladder:2|skin:2|head_neck:2 ENST00000269305 4 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 SETD2 X1572 X:6 1572 sp:6 0.0645658226264237 0.0645658226264237 0.216851597848245 6 lung:1|kidney:3|bowel:1|stomach:1 ENST00000409792 3 splice site 0.0 0.0 0.0 6.0 6.0 0.0 0.0 0.0 1.0 CIC P203 P:4 203 A:1|S:2|L:1 0.0647601453800692 0.823587958395122 0.0647601453800692 4 uterus:1|brain:3 ENST00000575354 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KMT2C R56 R:10 56 Q:6|*:4 0.0649389721368166 0.0649389721368166 0.444368348683291 10 lung:1|uterus:4|bowel:3|breast:1|head_neck:1 ENST00000262189 6 single residue 6.0 4.0 0.0 0.0 10.0 0.6 0.4 0.0 0.0 KMT2C R4549 R:9 4549 C:7|S:1|H:1 0.0649389721368166 0.0649389721368166 1 9 unk:1|pancreas:1|bladder:2|skin:2|bowel:1|prostate:1|breast:1 ENST00000262189 6 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 MEF2B K4 K:4 4 E:4 0.065125088740109 1 0.065125088740109 4 lymph:4 ENST00000162023 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 RIT1 A77 A:5 77 P:1|S:1|T:3 0.0651692609390733 0.0651692609390733 1 5 lung:2|biliary_tract:1|uterus:1|bowel:1 ENST00000368323 3 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 PTEN I67 I:4 67 T:2|V:1|K:1 0.0651819173076579 0.0651819173076579 1 4 ovary:1|uterus:1|soft_tissue:1|breast:1 ENST00000371953 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 PPP4R2 *418 *:2 418 Y:1|L:1 0.0652217461803095 1 0.0652217461803095 2 skin:2 ENST00000356692 5 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 PIK3CD R894 R:5 894 Q:1|R:4 0.0656422395683915 0.478019632786576 0.0656422395683915 5 stomach:3|prostate:2 ENST00000377346 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 KDM6A X76 X:3 76 sp:3 0.0657879846054171 0.480854349457074 0.0657879846054171 3 bladder:3 ENST00000377967 4 splice site 0.0 0.0 0.0 3.0 3.0 0.0 0.0 0.0 1.0 ERBB4 F1102 F:5 1102 C:4|F:1 0.0659327405024936 0.61234098738599 0.0659327405024936 5 bladder:1|bowel:1|stomach:3 ENST00000342788 4 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 ATM R2832 R:7 2832 C:6|S:1 0.066057625068094 0.066057625068094 1 7 lung:2|thyroid:1|skin:1|stomach:1|brain:1|breast:1 ENST00000278616 4 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 BCL2 N172 N:6 172 Q:1|S:3|N:2 0.0692871398183635 0.0692871398183635 0.127276313670163 6 lymph:5|bowel:1 ENST00000333681 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 FGFR2 P253 P:6 253 R:4|L:2 0.0694872697601985 0.0694872697601985 1 6 lung:2|ovary:1|uterus:1|bowel:1|breast:1 ENST00000358487 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 PTEN Y174 Y:4 174 D:1|H:1|*:2 0.07120415463729 0.07120415463729 1 4 skin:1|brain:1|breast:2 ENST00000371953 3 single residue 2.0 2.0 0.0 0.0 4.0 0.5 0.5 0.0 0.0 MET T222 T:7 222 T:7 0.0714242435038856 0.989325437262844 0.0714242435038856 7 uterus:2|skin:5 ENST00000397752 3 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 BRAF X327 X:3 327 sp:3 0.0717947351386339 1 0.0717947351386339 3 lung:1|skin:2 ENST00000288602 6 splice site 0.0 0.0 0.0 3.0 3.0 0.0 0.0 0.0 1.0 TGFBR1 I259 I:3 259 I:2|N:1 0.0725830208046979 1 0.0725830208046979 3 cervix:2|skin:1 ENST00000374994 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 ERBB4 S774 S:4 774 R:1|G:2|N:1 0.0732416810636865 1 0.0732416810636865 4 stomach:4 ENST00000342788 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CCND1 C47 C:4 47 S:3|G:1 0.0733365452924601 0.86255713741553 0.0733365452924601 4 lymph:3|blood:1 ENST00000227507 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ARID1A X911 X:5 911 sp:5 0.0734346156772229 0.0734346156772229 1 5 lung:2|biliary_tract:1|bladder:1|skin:1 ENST00000324856 7 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 ERBB2 A293 A:6 293 P:1|T:4|V:1 0.0736415328665745 0.0736415328665745 1 6 lung:1|ovary:1|unk:1|bowel:2|skin:1 ENST00000269571 5 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 ERBB2 I767 I:9 767 M:9 0.074155571453423 0.074155571453423 1 9 bladder:4|bowel:1|breast:3|head_neck:1 ENST00000269571 5 single residue 9.0 0.0 0.0 0.0 9.0 1.0 0.0 0.0 0.0 BRD4 P1065 P:4 1065 P:3|R:1 0.0743406064704526 1 0.0743406064704526 4 skin:3|stomach:1 ENST00000263377 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KDM6A X129 X:5 129 sp:5 0.0772719082059661 0.328629477111002 0.0772719082059661 5 kidney:1|bladder:3|head_neck:1 ENST00000377967 4 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 PGR R836 R:9 836 Q:8|*:1 0.0776186817443919 0.207437133112986 0.0776186817443919 9 uterus:1|skin:5|bowel:2|brain:1 ENST00000325455 5 single residue 8.0 1.0 0.0 0.0 9.0 0.8888888888888888 0.1111111111111111 0.0 0.0 PTPRS R1492 R:8 1492 Q:3|R:1|W:4 0.0779048132747687 0.0779048132747687 1 8 kidney:1|bladder:1|bowel:3|stomach:2|head_neck:1 ENST00000357368 4 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 CBL C384 C:4 384 R:3|W:1 0.0780706952247139 0.0780706952247139 0.361440965972942 4 skin:1|soft_tissue:1|brain:2 ENST00000264033 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 H1-2 E115 E:4 115 K:4 0.079068457929701 1 0.079068457929701 4 breast:4 ENST00000343677 2 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 MAP3K13 X502 X:4 502 sp:4 0.0818345274306637 1 0.0818345274306637 4 stomach:3|prostate:1 ENST00000265026 3 splice site 0.0 0.0 0.0 4.0 4.0 0.0 0.0 0.0 1.0 PDGFRA C235 C:4 235 R:1|S:1|Y:2 0.0823670577038415 1 0.0823670577038415 4 skin:1|brain:3 ENST00000257290 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ERCC3 L713 L:2 713 L:2 0.083015618806217 1 0.083015618806217 2 blood:2 ENST00000285398 2 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 PTEN I101 I:4 101 T:4 0.083264069890969 0.083264069890969 1 4 unk:1|soft_tissue:1|brain:2 ENST00000371953 3 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 NFE2L2 I28 I:3 28 T:3 0.0834734884151312 0.0834734884151312 1 3 lung:1|pancreas:1|head_neck:1 ENST00000397062 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 CDH1 Y190 Y:3 190 C:3 0.0839076552994752 1 0.0839076552994752 3 stomach:3 ENST00000261769 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 IRS2 G1057 G:3 1057 D:3 0.0854265037781273 1 0.0854265037781273 3 lymph:2|bowel:1 ENST00000375856 3 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PIM1 N7 N:4 7 N:4 0.0854284093090971 0.410166241001175 0.0854284093090971 4 lymph:4 ENST00000373509 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SMAD2 R321 R:9 321 Q:5|*:4 0.0862675631729402 0.0876402846229849 0.0862675631729402 9 bowel:6|stomach:3 ENST00000262160 6 single residue 5.0 4.0 0.0 0.0 9.0 0.5555555555555556 0.4444444444444444 0.0 0.0 SPOP K129 K:3 129 E:3 0.086449492395681 1 0.086449492395681 3 prostate:3 ENST00000347630 2 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 CARD11 R423 R:6 423 Q:3|R:1|W:2 0.0866304024478113 1 0.0866304024478113 6 lung:1|bowel:5 ENST00000396946 4 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 TRAF7 R189 R:4 189 P:1|R:1|W:1|L:1 0.086969413826998 0.499608665262582 0.086969413826998 4 lung:3|bladder:1 ENST00000326181 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 KIT R888 R:7 888 Q:3|R:1|W:3 0.0873753872499497 0.0873753872499497 1 7 ovary:1|uterus:1|liver:1|adrenal_gland:1|bowel:2|soft_tissue:1 ENST00000288135 5 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 IKZF1 E304 E:8 304 Q:1|K:7 0.0875564839666501 1 0.0875564839666501 8 unk:1|bladder:1|skin:6 ENST00000331340 3 single residue 8.0 0.0 0.0 0.0 8.0 1.0 0.0 0.0 0.0 RHOA L69 L:5 69 P:2|R:2|M:1 0.0884860446408663 0.0884860446408663 0.749192374965767 5 lymph:2|bowel:1|stomach:2 ENST00000418115 1 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 TNFRSF14 C111 C:3 111 W:2|Y:1 0.0888304463274096 0.757746371414645 0.0888304463274096 3 lymph:1|bladder:2 ENST00000355716 4 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 PMS2 K651 K:4 651 R:4 0.089408084970774 0.493638798137009 0.089408084970774 4 soft_tissue:1|testis:2|brain:1 ENST00000265849 7 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 MAP2K1 N122 N:3 122 D:3 0.089479789390335 0.089479789390335 1 3 lung:1|lymph:1|stomach:1 ENST00000307102 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 SDHAF2 S10 S:5 10 A:1|*:1|L:3 0.090116860936781 0.090116860936781 0.115674115845195 5 lung:3|cervix:1|kidney:1 ENST00000301761 2 single residue 4.0 1.0 0.0 0.0 5.0 0.8 0.2 0.0 0.0 RAC1 K135 K:2 135 R:1|N:1 0.0909173130305242 0.779712825164341 0.0909173130305242 2 head_neck:2 ENST00000356142 4 single residue 2.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 CCND1 E9 E:5 9 D:1|E:3|K:1 0.0910705118800777 0.0910705118800777 1 5 lymph:1|bowel:1|blood:2|breast:1 ENST00000227507 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 EIF4A2 M1 M:4 1 R:1|V:1|I:1|K:1 0.0913429534541545 0.0913429534541545 1 4 lung:1|skin:1|prostate:1|breast:1 ENST00000323963 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CREBBP I1431 I:4 1431 S:1|V:1|I:1|N:1 0.0936694562481603 0.0936694562481603 0.576881687654456 4 lymph:1|bladder:2|head_neck:1 ENST00000262367 5 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 ARID1B T1652 T:5 1652 A:1|T:1|M:3 0.0938231260288271 0.512481927124766 0.0938231260288271 5 bladder:1|bowel:1|skin:2|stomach:1 ENST00000346085 5 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 VHL W117 W:6 117 C:1|*:2|L:3 0.094271768237484 0.094271768237484 0.170983641023658 6 kidney:5|pancreas:1 ENST00000256474 2 single residue 4.0 2.0 0.0 0.0 6.0 0.6666666666666666 0.3333333333333333 0.0 0.0 VHL Y112 Y:5 112 C:1|D:1|Y:1|*:2 0.094271768237484 0.094271768237484 1 5 kidney:3|pancreas:1|brain:1 ENST00000256474 2 single residue 3.0 2.0 0.0 0.0 5.0 0.6 0.4 0.0 0.0 NSD2 T1150 T:3 1150 A:3 0.0946426518532276 1 0.0946426518532276 3 lymph:2|brain:1 ENST00000382891 5 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 SOS1 A90 A:5 90 A:3|T:1|V:1 0.0949773985392201 0.0949773985392201 1 5 lung:1|kidney:1|skin:2|brain:1 ENST00000402219 2 single residue 5.0 0.0 0.0 0.0 5.0 1.0 0.0 0.0 0.0 SMAD2 T303 T:3 303 R:2|I:1 0.0953428440091016 1 0.0953428440091016 3 bowel:3 ENST00000262160 6 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 RB1 X406 X:9 406 sp:9 0.0953651983533237 0.0953651983533237 1 9 lung:1|ovary:1|liver:1|pancreas:1|bladder:1|prostate:1|brain:1|breast:2 ENST00000267163 4 splice site 0.0 0.0 0.0 9.0 9.0 0.0 0.0 0.0 1.0 EP300 L415 L:3 415 P:3 0.0954266946248702 0.960651893932198 0.0954266946248702 3 lymph:2|bladder:1 ENST00000263253 7 single residue 3.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 SMARCA4 R1157 R:7 1157 Q:3|W:4 0.09557979887796 0.09557979887796 1 7 lymph:1|thymus:1|bladder:2|bowel:2|skin:1 ENST00000358026 2 single residue 7.0 0.0 0.0 0.0 7.0 1.0 0.0 0.0 0.0 SMAD2 P305 P:4 305 Q:1|T:1|L:2 0.0969117927764253 0.277746097560079 0.0969117927764253 4 bowel:3|prostate:1 ENST00000262160 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 SF3B1 V701 V:4 701 A:1|F:2|I:1 0.0969151861465262 0.0969151861465262 1 4 lung:1|lymph:1|skin:1|blood:1 ENST00000335508 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 NOTCH1 I471 I:4 471 T:4 0.098353622293025 0.098353622293025 1 4 pancreas:1|stomach:2|head_neck:1 ENST00000277541 6 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 RAC1 C18 C:4 18 S:1|F:1|Y:2 0.0992431503740995 0.0992431503740995 0.393912945814012 4 lung:1|bowel:1|head_neck:2 ENST00000356142 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 CTCF M1 M:4 1 T:1|V:2|I:1 0.0997648063724961 0.0997648063724961 1 4 pancreas:1|stomach:1|soft_tissue:1|breast:1 ENST00000264010 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 STK11 G196 G:6 196 R:1|V:4|G:1 0.0999093296754989 0.0999093296754989 1 6 lung:3|unk:1|skin:1|bowel:1 ENST00000326873 7 single residue 6.0 0.0 0.0 0.0 6.0 1.0 0.0 0.0 0.0 STK11 X200 X:5 200 sp:5 0.0999093296754989 0.0999093296754989 0.231458186323875 5 lung:4|unk:1 ENST00000326873 7 splice site 0.0 0.0 0.0 5.0 5.0 0.0 0.0 0.0 1.0 FBXW7 T385 T:4 385 P:1|I:1|K:2 0.0999935786199138 0.0999935786199138 1 4 uterus:1|bladder:1|stomach:1|blood:1 ENST00000281708 4 single residue 4.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 0.0 FBXW7 R393 R:7 393 Q:3|*:4 0.0999935786199138 0.0999935786199138 1 7 uterus:1|biliary_tract:1|pancreas:1|bowel:2|stomach:1|head_neck:1 ENST00000281708 4 single residue 3.0 4.0 0.0 0.0 7.0 0.42857142857142855 0.5714285714285714 0.0 0.0 SMARCA4 546 QK:5 546 K546del:5 0.000230672905611517 5 lymph:1|brain:4 1 ENST00000358026 2 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 CDKN2A 27-42 EV:1|ALPN:1|GA:1|PNAPN:1|LEAGALP:3|VRALLEA:4|RALLEA:1 27-42 R29_A34del:1|V28_E33del:4|E27del:1|A36_N39delinsD:1|L32_L37del:3|N39_N42del:1|G35_A36del:1 8.77193090544841e-05 12 lung:3|cervix:1|pancreas:1|bladder:1|skin:2|stomach:3|head_neck:1 15 ENST00000579755 1 in-frame indel 0.0 0.0 12.0 0.0 12.0 0.0 0.0 1.0 0.0 SMAD4 357-377 RFCLGQLSNVH:1|PSGGDRFCLG:1|SGGD:1|LGQLSNVHRTEAIE:1|DRFCLG:2|RFCL:1|FC:1 357-377 G358_D360del:1|R361_L364del:1|C363del:1|F362_H371del:1|S357_G365del:1|G365_E377del:1|R361_G365del:2 3.6822392551777e-06 8 pancreas:3|bowel:2|stomach:3 20 ENST00000342988 3 in-frame indel 0.0 0.0 8.0 0.0 8.0 0.0 0.0 1.0 0.0 SMAD4 536-546 EVLHTMPIA:1|L:2|LDE:2 536-546 L536_E538delinsQ:2|D537_E538dup:1|L540del:1|V539_A546del:1 0.0247790280835321 5 biliary_tract:1|bladder:1|bowel:1|stomach:2 10 ENST00000342988 3 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 BAP1 25-34 VKGVQ:1|E:2|Y:1|KGVQVEEIYD:1 25-34 K25_Q28del:1|K25_D34delinsN:1|Y33del:1|E31del:2 0.0475318811088585 5 eye:1|kidney:1|skin:1|pleura:1|brain:1 9 ENST00000460680 1 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 SMARCB1 364 EK:5 364 K364del:5 0.000385365731765089 5 biliary_tract:1|stomach:2|brain:2 1 ENST00000263121 7 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 FOXA1 249-409 NMFENG:1|DSGNMFE:1|FENGCYL:1|G:1|GNMFE:2|GGSGAKGG:1|KRFK:1|APAPG:1|Q:1|NHPF:1|DSGN:1|NMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPISSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSS:1|FENG:1|MFENGCY:1|RQKRFKCEKQPGAGGGGGSG:1|QKRFKC:1|SGNMFENGCYL:2|SGNMF:1|SS:1|CYLR:1|MFEN:1|NMFENGC:1|GNMFENG:2|-:2|RFKCEKQ:1|FEN:6|QKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKD:1|SGN:1|ENG:2|FE:1 249-409 C258_R261del:1|F254_E255del:1|D249_F254del:1|K264_K267del:1|K264dup:1|A323_P326del:1|M253_Y259del:1|S250_N252del:1|F254_N256delinsY:6|D249_N252del:1|F254_L260del:1|S250_Y259del:2|N397_F400del:1|G251_G257del:2|N252_C258del:1|S250_F254del:1|G251_F254del:2|N252_G257del:1|S409del:1|R265_K270del:1|N252_S408del:1|Q263_D296delinsH:1|E255_N256del:2|K267dup:1|Q263_C268del:1|G284_G290del:1|Q263_G281del:1|S282_G283dup:1|F254_G257delinsC:1|Q263del:1|M253_N256del:1 6.25580148545088e-73 40 prostate:34|breast:6 160 ENST00000250448 2 in-frame indel 0.0 0.0 40.0 0.0 40.0 0.0 0.0 1.0 0.0 MED12 41-55 FNNQPAVS:1|QPAVSGDE:1|NVKQGFNNQPAVS:1|GF:1|KQGFN:1 41-55 N46_S52del:1|V41_S52del:1|G44_F45del:1|K42_N46del:1|P49_E55del:1 7.95052431352778e-07 5 bladder:1|bowel:1|breast:3 14 ENST00000374080 3 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 CEBPA 307-311 E:1|NVE:1|-:2 307-311 T310_Q311insKQNP:1|V308dup:1|N307_E309delinsK:1|T310_Q311insW:1 0.00506139021814322 4 blood:4 4 ENST00000498907 2 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 PIK3R1 439-470 QEKSRE:1|KKLHEYNTQFQE:1|QE:1|QFQEK:1|YN:1|LHEYNTQFQEK:1|RLYEE:1|IE:1|VGKKLHE:1|NTQFQ:1|EK:3|DNIEAVGKKLHEYNT:3|-:6|REYDR:1|EDNIEAVGKK:1|RE:2|EDNIEAVGKKLH:1|EY:1|QEK:1|LHEYNTQ:1|RL:1|DRLY:1|EYDRL:4|FQEKS:2|TQFQEK:1|D:1|E:2|H:2|LHE:1|NTQ:1|L:6|DNIEAVGKKLHEY:1|N:1|Q:2|R:4|LYEEY:1|T:1|HEYNT:1|Y:2|KE:1|KL:3|GKKL:1|SREYD:2|TQF:3|YEEY:1|EYNTQFQEKSR:1|HEY:6|EYNTQFQ:2|KLHEYN:3 439-470 E439del:1|Q455_S460dup:1|H450_E451insVH:2|Q457_S460del:2|H450_E451insD:1|L466_Y470delinsF:1|K459del:3|I442_N453del:1|D464_Y467del:4|E451del:1|D440_K448del:1|E458del:2|E468_E469insGEYDRLYE:1|E462_R465del:2|R461_E462delinsQ:2|H450_Q455dup:1|N453_Q455delinsK:1|G446_L449delinsV:1|N453_Q457del:1|N453del:2|E451_Y452del:6|Q455_F456insL:2|D464_Y470dup:1|E462_Y463delinsD:1|H450_E451dup:1|Q455_K459del:1|D440_E451del:1|L466_E469del:1|L449_H450insQ:1|E458_K459del:1|Q457_E462del:1|H450_T454del:1|K448_Y452del:1|F456_K459del:1|H450_K459del:1|F456_Q457del:3|Y463_E468dup:1|D440del:1|D464_E468dup:1|L466del:1|N453_Y463del:1|K448_N453del:2|E462dup:1|E458_Y463dup:1|H450_E451del:1|H450del:1|I442_E443delinsK:1|R465_Y467del:1|N441_T454del:3|E468_E469insGLYE:1|N453_D464dup:1|Y467_Y470del:1|Y452_N453insF:1|Y452_Q457del:2|Y452dup:2|L449_K459del:1|L449del:3|R465dup:1|L449_Q455del:1|S460_D464del:1|E468_Y470dup:1|G446_E451del:1 9.34522866603558e-183 88 lung:4|ovary:2|uterus:31|bowel:4|stomach:3|soft_tissue:1|brain:29|head_neck:3|breast:11 31 ENST00000274335 5 in-frame indel 0.0 0.0 88.0 0.0 88.0 0.0 0.0 1.0 0.0 PIK3R1 558-582 LR:2|KTRDQYL:1|DL:1|DQYLM:1|I:1|L:2|LRKT:2|IQLR:1|MNSIKPDL:1|KPDLIQL:1|R:3|Y:1|QL:1|IKPDL:5|REIDK:2|MN:1|IK:3|TRDQYL:1|QY:1|KT:7|-:1|DLIQLRKTRDQYL:1|PDLIQLRKTR:1|IKP:1|QLRK:1|RD:1|IQLRK:1|NSIKP:1|TR:2|LIQLRKTRDQYL:1 558-582 L570_D578del:1|K575_L581delinsM:1|P568_L573del:1|I571_Q572insR:1|L573del:1|L573_R574del:1|D569_L581delinsE:1|I566_P568delinsT:1|T576del:6|K567del:3|D569_L570delinsV:1|Y580_L581insF:1|K567_L570del:4|R574del:4|K575_R577del:2|D569dup:1|M563_L570delinsI:1|N564_P568delinsT:1|K567_I571del:1|R577_L581del:1|M563_N564delinsI:1|E558_K561del:1|K575_R577dup:1|I571_R574del:1|D578_M582delinsE:1|L570_I571insY:1|E558_R562del:1|K575_T576del:1|I571_L581del:1|R577_D578del:1|R577del:2|I571_K575del:1|L573_K575del:1|Q579_Y580delinsH:1 8.12893453430381e-89 49 lung:2|cervix:2|kidney:1|uterus:22|liver:1|bowel:2|prostate:3|stomach:1|brain:7|head_neck:2|breast:6 24 ENST00000274335 5 in-frame indel 0.0 0.0 49.0 0.0 49.0 0.0 0.0 1.0 0.0 PIK3R1 397-420 VVELINH:1|ELINHYRNESLAQYNPK:1|EL:1|LTFSSV:1|VELINHYRNESL:1|SSVVEL:1|VEL:1|LI:2|SVVELIN:1 397-420 S399_L404del:1|E403_L404del:1|V401_H407del:1|E403_L404delinsV:1|V402_L413del:1|I405del:2|T397_V401del:1|I405_L420del:1|V401_N406del:1 4.95223936988698e-10 10 uterus:4|bowel:1|brain:4|breast:1 23 ENST00000274335 5 in-frame indel 0.0 0.0 10.0 0.0 10.0 0.0 0.0 1.0 0.0 PIK3R1 378-380 KL:3|K:1|NK:1 378-380 L380del:3|N378del:1|K379del:1 0.00935831892553836 5 brain:3|breast:2 2 ENST00000274335 5 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 TP53 229-292 LL:3|LTI:1|RR:1|A:2|C:3|NS:2|CACPGRDR:1|G:1|TIIT:1|I:3|L:4|M:1|N:2|TLEDSS:2|R:2|LTIITL:1|S:2|SFE:2|SF:1|CNSS:1|T:1|YM:1|RVCACPG:1|EEENLRKKG:1|NLLGRNS:1|NLLGRN:1|RNSFEVR:1|Y:1|ACPGRDRRTEE:1|EE:2|SS:1|GMNRRP:1|MGGMNRRPILTIIT:1|IT:10|CN:1|CTTIHY:1|GGM:1|SSCM:1|-:3|NSS:2|YNYMC:1|CT:1|PIL:1|CNSSCM:1|TI:1|PI:1|MCNS:1 229-292 D281_R282insP:1|N263_N268del:1|G244_M246delinsV:1|S240_C242del:1|F270del:1|C277dup:1|L252del:3|I255dup:1|S269_E271del:1|P250_L252del:1|C229_T230del:1|S269_E271delinsK:1|Y234_M237del:1|L264_N268del:1|R282_R283del:1|N235del:2|C238_N239delinsY:1|C238_M243del:1|T231_I232insTDCTT:1|V274dup:1|E285_K292del:1|L252dup:1|M243_I255del:1|N268_R273del:1|S240_S241del:1|I254_T256del:1|S260_L264dup:1|C275_R282delinsW:1|T256_S260del:2|G245_P250delinsA:1|N235_Y236dup:1|M237_N239del:1|T253_L257del:1|T256del:1|C229_H233del:1|N239dup:2|G262del:1|C238_S240del:1|V274_G279del:1|Y236_M237delinsL:1|N239_S240del:2|A276_C277dup:1|L252_I254del:1|T253dup:2|V274_C275dup:2|E286_E287del:2|A276_E285del:1|V272_R273insL:1|S241dup:2|P250_I251delinsL:1|Y234del:1|L265del:3|I255del:9|N239_S241del:2|T231_I232del:1 1.46521691051924e-64 76 bowel:12|skin:1|stomach:11|brain:8|head_neck:5|lung:14|ovary:6|lymph:1|unk:4|uterus:3|thyroid:1|pancreas:3|prostate:1|soft_tissue:3|breast:3 63 ENST00000269305 4 in-frame indel 0.0 0.0 76.0 0.0 76.0 0.0 0.0 1.0 0.0 TP53 128-163 TCP:1|A:2|VQLWVDSTPPPG:1|VRA:2|D:1|PPG:1|G:1|TRVRAMAI:1|L:1|P:1|R:2|QL:1|QLAKTCP:1|SP:1|TPPPGTRVR:1|TRVR:1|CQL:1|DST:1|AI:1|LAKTCP:1|-:4|GT:1|RA:1|IY:1|KTCP:1|AKTCPVQL:1|PAL:1|TP:1|NK:4|TR:1 128-163 D148_T155dup:1|N131del:4|C141_P142del:1|P142dup:1|D148del:1|K139_P142delinsT:1|T150_R158del:1|V157_R158del:2|R158_A159dup:1|A138_P142del:1|A161_I162del:1|A159del:1|D148_T150del:1|V147_D148dup:1|L130del:1|Q136del:1|R158_A159del:1|A138_L145del:1|V143_P153del:1|T155_R158del:1|L130_A138dup:1|P153_G154del:1|T155_R156del:1|R156del:2|Q136_C141del:1|I162dup:1|P128del:1|I162_Y163delinsN:1|C135_L137delinsW:1|V157_R158dup:1|P128_L130del:1|G154_T155del:1|T155_A161del:1|P153del:1 2.55825013475141e-22 39 liver:1|bowel:2|stomach:4|brain:6|head_neck:2|lung:8|ovary:4|uterus:1|ampulla_of_vater:1|pancreas:1|bladder:1|prostate:1|soft_tissue:1|breast:6 35 ENST00000269305 4 in-frame indel 0.0 0.0 39.0 0.0 39.0 0.0 0.0 1.0 0.0 TP53 173-187 HERCSD:1|HH:1|PHH:1|SDSDG:1|ERCSD:1|V:1|VVRR:1|PHHERC:10|PHHERCS:2|RCPHH:1|-:1 173-187 H179del:1|H178_S183del:2|C176dup:1|P177_C182del:10|C176_H179del:1|E180_D184del:1|P177_H178del:1|S183_G187delinsC:1|H179_D184del:1|V173dup:1|V173_R175del:1 8.83278816666912e-07 21 adrenal_gland:1|bowel:2|skin:1|stomach:4|brain:1|head_neck:3|lung:1|ovary:1|thyroid:1|pancreas:1|soft_tissue:1|prostate:1|breast:3 14 ENST00000269305 4 in-frame indel 0.0 0.0 21.0 0.0 21.0 0.0 0.0 1.0 0.0 TP53 191-206 PQ:11|IRVEGN:1|RVEGNLR:1|EGNLRVE:2|PQHLIRVEGNLR:1|QH:1|EYLD:1|VEGN:1|RVEYL:1 191-206 E204_L206del:1|Q192del:1|V197_N200del:1|P191del:11|G199_E204del:3|P191_L201del:1|R202_L206del:1|I195_G199del:1 3.4723699042568e-06 20 lung:2|cervix:1|ovary:2|pancreas:1|bowel:1|stomach:3|soft_tissue:2|prostate:2|testis:1|brain:4|head_neck:1 15 ENST00000269305 4 in-frame indel 0.0 0.0 20.0 0.0 20.0 0.0 0.0 1.0 0.0 PIK3CA 110-114 IL:2|NR:1|E:18|K:4|KI:1 110-114 K111_I112del:1|I112_L113del:1|E110_K111dup:1|E110del:17|L113del:1|N114del:1|K111del:4 2.94617710868453e-59 26 lung:1|uterus:5|bowel:4|soft_tissue:1|prostate:1|brain:7|breast:6|head_neck:1 4 ENST00000263967 3 in-frame indel 0.0 0.0 26.0 0.0 26.0 0.0 0.0 1.0 0.0 PIK3CA 436-466 VPHGLEDLL:1|GSN:1|LLNPIG:1|LEDLLNPIGVTGSNP:1|GLEDLLNP:1|PHGLEDL:1|WPVPHGLEDL:1|EDLLNPIGVT:1|VPHGL:1|HGLED:1|T:1|LE:4|HGLEDLLNPI:1|ED:1 436-466 P449_L456del:1|L455_G460delinsF:1|E453_P466del:1|E453_D454del:1|E453_T462del:1|P447_L455del:1|L452_P458del:1|G463_N465delinsD:1|E453del:4|L452_G460del:1|H450_L455del:1|G451_D454del:1|P449_L452del:1|L436_P449dup:1 4.11312718295531e-35 17 uterus:3|bowel:2|stomach:1|bone:1|brain:7|breast:3 30 ENST00000263967 3 in-frame indel 0.0 0.0 17.0 0.0 17.0 0.0 0.0 1.0 0.0 PIK3CA 102-108 NR:1|I:1|GNR:3|EPV:1|IE:1|VGN:1 102-108 I102del:1|G106_N107del:1|I102_E103delinsK:1|P104_V105del:1|G106_R108del:3|R108del:1 5.94659702796749e-13 8 uterus:2|bowel:3|breast:3 6 ENST00000263967 3 in-frame indel 0.0 0.0 8.0 0.0 8.0 0.0 0.0 1.0 0.0 PIK3CA 419-422 HCPL:1|HC:3 419-422 H419_C420del:3|H419_L422del:1 0.00024116143603727 4 uterus:1|prostate:1|breast:2 3 ENST00000263967 3 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 PIK3CA 10-18 LWGIHLMPP:1|LWGIHLM:1|WGIH:1 10-18 W11_P18del:1|L10_M16del:1|W11_H14delinsY:1 0.0184009618681251 3 uterus:1|bladder:1|brain:1 8 ENST00000263967 3 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 ERBB2 772-775 V:1|-:33 772-775 M774dup:1|Y772_A775dup:33 1.41703102521153e-86 34 lung:25|ovary:1|unk:1|bladder:2|bowel:1|stomach:1|breast:3 3 ENST00000269571 5 in-frame indel 0.0 0.0 34.0 0.0 34.0 0.0 0.0 1.0 0.0 ERBB2 778-780 V:8|-:4 778-780 G778_P780dup:12 7.40770850939387e-24 12 lung:6|breast:6 2 ENST00000269571 5 in-frame indel 0.0 0.0 12.0 0.0 12.0 0.0 0.0 1.0 0.0 EGFR 745-759 KANKEI:1|TSPKANKEI:2|LREATS:2|KELREA:78|ELREA:46|ATSPKANKE:1|I:1|ELR:3|SPKANKEI:1|LREATSP:8|ELREAT:12|EATSPK:1 745-759 E746_A750del:123|K754_I759del:1|E746_T751delinsA:3|L747_P753delinsS:8|L747_S752del:2|K745_E746insVPVAIK:1|T751_A755del:1|L747_T751del:9|L747_E749del:3|T751_E758del:1|S752_I759del:3 0 155 lung:155 14 ENST00000275493 2 in-frame indel 0.0 0.0 155.0 0.0 155.0 0.0 0.0 1.0 0.0 EGFR 764-774 P:6|A:5|D:9|M:5|-:4|N:4 764-774 D770_P772dup:1|P772_H773dup:1|N771_P772insHH:1|N771_P772insV:1|H773_V774dup:1|Y764_D770dup:1|H773dup:5|P772_H773insTPNP:1|D770_N771insGF:1|D770_N771insY:1|N771_H773dup:7|A767_V769dup:5|N771_P772insH:1|D770_N771insG:1|S768_D770dup:4|D770_N771insGL:1 1.49808764272147e-72 33 lung:22|uterus:1|bladder:4|brain:6 10 ENST00000275493 2 in-frame indel 0.0 0.0 33.0 0.0 33.0 0.0 0.0 1.0 0.0 EGFR 709-710 ET:9 709-710 E709_T710delinsD:9 2.4645533400901e-13 9 lung:9 1 ENST00000275493 2 in-frame indel 0.0 0.0 9.0 0.0 9.0 0.0 0.0 1.0 0.0 NOTCH1 356-359 FY:17|SF:2|C:1|YC:1 356-359 C359del:1|Y358del:1|S356del:2|F357del:17 3.46745075162572e-40 21 brain:19|head_neck:2 3 ENST00000277541 6 in-frame indel 0.0 0.0 21.0 0.0 21.0 0.0 0.0 1.0 0.0 NOTCH1 338 DD:4 338 D338del:4 0.0110220456602372 4 brain:4 1 ENST00000277541 6 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 MDC1 1020-1028 IRAAEKVSR:1|K:2 1020-1028 I1020_R1028del:1|K1025del:2 0.0133207140057804 3 liver:1|stomach:2 8 ENST00000376406 3 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 SOX9 152-167 EKRPFVEEAERLRVQHK:1|KR:1|K:3 152-167 K167del:3|R152del:1|R152_K167del:1 0.0645000415402425 5 biliary_tract:1|bowel:3|stomach:1 15 ENST00000245479 2 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 CTNNB1 23-71 DSGIHS:1|SGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGF:1|QQQSYLD:1|PS:6|PSLSGKGNPEEEDVDTS:1|TTTAPSLS:1|YLDSGI:1|TAPSLSGK:1|-:1|TTTAPS:1|DS:1|APSLSGKGN:1|DSGI:1|HWQQQSYLD:1|HWQQQSYLDSGI:1|QSYLD:1|DSGIHSGA:1|SGATTTAP:1|VSHWQQQSYLDS:1|SYLD:2|LDS:1 23-71 S23_S33del:1|T41_S47del:1|S33_A39del:1|S45_P52del:1|W25_H36del:1|Q28_D32delinsH:1|T41_S45del:1|G38_P44del:1|L31_I35del:1|Q26_D32delinsH:1|D32_S33del:1|S45del:6|L31_S33del:1|D32_S37delinsA:1|P44_S60del:1|D32_I35delinsV:1|T42_K49del:1|G34_S71del:1|W25_D32del:1|Y30_S33del:2|A43_P44dup:1 6.5334508895157e-60 27 lung:2|ovary:1|liver:9|adrenal_gland:3|bowel:5|skin:4|prostate:1|stomach:1|breast:1 48 ENST00000349496 5 in-frame indel 0.0 0.0 27.0 0.0 27.0 0.0 0.0 1.0 0.0 MAP2K1 99-107 LEI:4|IK:1|LIHLEIK:1|PAI:1|KPA:1 99-107 I99_K104del:1|E102_I103del:4|P105_A106del:1|I103_K104del:1|P105_I107delinsL:1 3.29106622127611e-12 8 lung:2|bowel:1|skin:4|blood:1 8 ENST00000307102 5 in-frame indel 0.0 0.0 8.0 0.0 8.0 0.0 0.0 1.0 0.0 CREBBP 1680 SL:16 1680 S1680del:16 3.38918085369556e-29 16 lung:1|lymph:7|uterus:1|bladder:2|bowel:2|stomach:1|penis:1|brain:1 1 ENST00000262367 5 in-frame indel 0.0 0.0 16.0 0.0 16.0 0.0 0.0 1.0 0.0 H1-2 23 K:4 23 K23del:4 0.0155813440448199 4 bowel:3|breast:1 1 ENST00000343677 2 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 MTOR 1450-1468 YEKLHEW:1|D:2|WEDAL:1|DALVAYDKKMD:1 1450-1468 W1456_L1460delinsC:1|Y1450_W1456del:1|A1459_D1468del:1|E1455_D1458dup:1|E1455_E1457dup:1 4.14767933010376e-08 5 kidney:2|uterus:1|bowel:2 18 ENST00000361445 4 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 KIT 550-580 GNNYVYIDP:1|WKV:1|KPMYEV:1|VVEEINGN:1|QWKVVEEINGNNYVYID:1|KVV:2|KVVEEING:1|YD:7|L:1|YE:1|PMYEVQW:1|VQWKVVEEINGNNYVYID:1|T:1|V:1|MYE:1|VYIDPTQL:1|VVEEINGNNYVYIDP:1|QWK:10|KP:1|QWKVVE:1|PMYEV:1|PMYEVQWKVVEEINGNNYVY:1|-:2|NNYVYIDPT:1|GNNYVYIDPT:1|KVVE:2|MYEV:1|QWKVV:1|PM:1|PMY:1|TQ:1 550-580 Q575del:1|W557_K558del:10|T574_H580dup:1|V559_G565del:1|V560del:1|M552_W557del:1|Y553_E554del:1|M552_V555delinsI:1|Y578_D579insEQQLPY:1|M552_E554delinsI:1|P551_Y553delinsH:1|P551_M552delinsL:1|Q556_D572del:2|W557_V559delinsF:1|D579del:7|M552_V555del:1|V559_P573del:1|K558_V560delinsN:1|L576del:1|P551_V555del:1|N566_P573del:2|Y570_L576del:1|V559_N566delinsD:1|V559_E561del:2|K550_P551del:1|Q556_V560delinsH:1|K558_V560del:1|L576_H580dup:1|G565_T574delinsA:1|W557_E561del:1|M552_Y570del:1 1.9774818328683e-126 49 lung:1|skin:3|bowel:2|soft_tissue:39|testis:2|vulva:1|breast:1 30 ENST00000288135 5 in-frame indel 0.0 0.0 49.0 0.0 49.0 0.0 0.0 1.0 0.0 KIT 502-503 S:8 502-503 A502_Y503dup:8 1.06961034696328e-12 8 soft_tissue:8 1 ENST00000288135 5 in-frame indel 0.0 0.0 8.0 0.0 8.0 0.0 0.0 1.0 0.0 LATS2 479-480 P:13 479-480 P479_A480dup:12|P479_A480insPP:1 5.22537914260909e-29 13 lung:2|kidney:1|thymus:1|bladder:1|bowel:1|stomach:4|prostate:1|testis:1|breast:1 1 ENST00000382592 4 in-frame indel 0.0 0.0 13.0 0.0 13.0 0.0 0.0 1.0 0.0 NFE2L2 21-42 VF:1|D:1|DI:1|REVF:1|EVFDFSQR:1|WRQDID:1|LGVSR:1|REVFDFSQ:1|DILWRQDID:1|-:1|GV:1|SR:1 21-42 D21_I22delinsE:1|R34_S40del:1|D27del:1|S33_R34del:1|R34_F37delinsL:1|G31del:1|W24_D29delinsY:1|I22_D29del:1|E35_R42del:1|F37del:1|I28dup:1|L30_S33del:1 7.43864692260498e-23 12 lung:8|liver:1|bladder:1|stomach:2 21 ENST00000397062 3 in-frame indel 0.0 0.0 12.0 0.0 12.0 0.0 0.0 1.0 0.0 NFE2L2 73-87 EE:1|AQLQLDEET:1|LDEETGE:1|LQLDEETGEFLPIQ:1 73-87 Q73_T80del:1|E79del:1|L74_Q87del:1|L76_E82del:1 0.00016858469436721 4 lung:1|unk:1|liver:1|breast:1 14 ENST00000397062 3 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 ESR1 422 MV:3 422 V422del:3 0.0451045963756131 3 uterus:1|breast:2 1 ENST00000206249 3 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 BRAF 592-604 A:1|KSRWS:1|T:3|VK:2|VKSR:1 592-604 V600_K601delinsE:2|V600_R603del:1|T599dup:3|K601_W604del:1|I592_A598dup:1 6.86065772143357e-11 8 lung:2|thyroid:2|bowel:2|skin:1|prostate:1 12 ENST00000288602 6 in-frame indel 0.0 0.0 8.0 0.0 8.0 0.0 0.0 1.0 0.0 BRAF 486-494 NVTA:1|TAPTP:1|APTPQQ:1|TAPTPQ:1|NVTAPT:3 486-494 N486_A489delinsK:1|N486_P490del:3|T488_Q493delinsK:1|P490_Q494del:1|T488_P492del:1 3.95006537267761e-09 7 thyroid:2|pancreas:3|prostate:1|blood:1 8 ENST00000288602 6 in-frame indel 0.0 0.0 7.0 0.0 7.0 0.0 0.0 1.0 0.0 MYC 298 PS:3 298 S298del:3 0.0205825305218148 3 bowel:1|prostate:1|head_neck:1 1 ENST00000377970 2 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 AKT2 60-84 Q:1|I:1|-:2 60-84 R76_I84dup:1|R67_L78dup:1|C60_I75dup:1|L78_Q79insHANTFVIRCL:1 2.07162746898975e-05 4 kidney:1|prostate:1|breast:2 24 ENST00000392038 2 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 VHL 70-80 VIFC:1|IF:4|-:1|NRS:1 70-80 R79_S80del:1|F76del:4|I75_C77del:1|E70_R79dup:1 0.0935986091028419 7 kidney:6|pancreas:1 10 ENST00000256474 2 in-frame indel 0.0 0.0 7.0 0.0 7.0 0.0 0.0 1.0 0.0 DAXX 457 EE:4|E:1 457 E457dup:1|E457del:4 8.61079815107147e-06 5 lung:1|biliary_tract:1|pancreas:3 1 ENST00000374542 5 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 U2AF1 222-223 RG:1|GGG:1|G:1 222-223 G222_G223del:1|G223dup:1|G223del:1 0.006574587762757 3 bladder:1|bowel:1|head_neck:1 1 ENST00000291552 4 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 ANKRD11 1461 KR:4 1461 K1461del:4 0.000507033000622495 4 uterus:1|bowel:1|skin:1|soft_tissue:1 1 ENST00000301030 4 in-frame indel 0.0 0.0 4.0 0.0 4.0 0.0 0.0 1.0 0.0 ANKRD11 1008-1015 EKEKKDGPD:1|K:2 1008-1015 K1012del:2|E1008_P1015del:1 0.0372217722530266 3 stomach:1|prostate:1|head_neck:1 7 ENST00000301030 4 in-frame indel 0.0 0.0 3.0 0.0 3.0 0.0 0.0 1.0 0.0 AKT1 65-77 L:1|-:1 65-77 P68_C77dup:1|T65_I75dup:1 0.0899335437451499 2 breast:2 12 ENST00000349310 3 in-frame indel 0.0 0.0 2.0 0.0 2.0 0.0 0.0 1.0 0.0 STAT3 616 EG:6 616 E616del:6 1.28595780031276e-08 6 lung:1|lymph:3|skin:1|stomach:1 1 ENST00000264657 5 in-frame indel 0.0 0.0 6.0 0.0 6.0 0.0 0.0 1.0 0.0 SRSF2 92-117 PPDSHH:1|PPDSHHSRR:1|GRPPDSHHSRRGPPPRRYGGGGYG:1|YGRPPDSH:1|YGRPPDSHH:1 92-117 P95_R102del:1|P95_R117del:1|Y92_H100del:1|Y92_H99del:1|P95_H99del:1 0.000120846881165768 5 eye:2|lymph:2|blood:1 25 ENST00000359995 5 in-frame indel 0.0 0.0 5.0 0.0 5.0 0.0 0.0 1.0 0.0 FLT3 578-613 D:2|E:5|F:2|G:1|W:1|Y:1|K:2|-:13 578-613 D593_F594insSPEDNEYFYVD:1|E598_Y599insVAYVDFREYE:1|N587_D600dup:1|R595_E596insDYVDFR:1|Y597_K602dup:1|R595_L601dup:1|Y597_E598insDEYFYVDFREY:1|S585_F594dup:1|L601_K602insNVDFREYEYDL:1|S584_D600dup:1|Y599_D600insEYEYEYEY:1|M578_E598dup:1|Y599_D600insPAPQIMSTSTLISENMNIA:1|F612_G613insQGFYVDFREYEYDLKWEFPRENLEF:1|Y599_E604dup:1|E598_Y599insSGSSDNEYFYVDFREYE:1|D586_E596dup:1|Y597_E598insAGSSDNEYFYVDFREY:1|S584_F605dup:1|F594_R595insGTGSSDNEYFYVDF:1|F594_D600dup:5|E604_F605insSPRGGNEYFYVDFREYEYDLKWE:1|E598_F612dup:1 9.64508469262637e-58 27 blood:27 35 ENST00000241453 7 in-frame indel 0.0 0.0 27.0 0.0 27.0 0.0 0.0 1.0 0.0 PTEN A34 34 1 1d5r_A(0.0) Hotspot-linked V:1 0 1 1 ucec:1 ENST00000371953 3 3d PTEN M35 35 1 1d5r_A(0.0) Hotspot-linked I:1 0 1 1 luad:1 ENST00000371953 3 3d PTEN L70 70 1 1d5r_A(0.0) Hotspot-linked H:1 0 1 1 gbm:1 ENST00000371953 3 3d PTEN H123 123 1 1d5r_A(0.0) Hotspot-linked D:2|Y:3|L:1 0 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 1 1d5r_A(0.0) Hotspot-linked R:1|S:1|G:1 0 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN G127 127 1 1d5r_A(0.0) Hotspot-linked R:3|E:1|V:1 0 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN K128 128 1 1d5r_A(0.0) Hotspot-linked Q:2|N:3 0 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN G129 129 1 1d5r_A(0.0) Hotspot-linked R:1|E:2|V:2 0 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN R130 130 1 1d5r_A(0.0) Hotspot P:3|Q:35|G:28|L:5 0 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN T131 131 1 1d5r_A(0.0) Hotspot-linked A:1 0 1 1 gbm:1 ENST00000371953 3 3d PTEN G132 132 1 1d5r_A(0.0) Hotspot-linked S:2|D:4|V:1 0 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN M134 134 1 1d5r_A(0.0) Hotspot-linked I:1 0 1 1 ucec:1 ENST00000371953 3 3d PTEN I135 135 1 1d5r_A(0.0) Hotspot-linked K:1 0 1 1 brca:1 ENST00000371953 3 3d PTEN C136 136 1 1d5r_A(0.0) Hotspot R:4|F:2|Y:2 0 8 5 coadread:1|gbm:3|hnsc:1|skcm:1|ucec:2 ENST00000371953 3 3d PTEN Y155 155 1 1d5r_A(0.0) Hotspot-linked C:2 0 2 2 ucs:1|ucec:1 ENST00000371953 3 3d PTEN D24 24 2 1d5r_A(0.0) Cluster-exclusive E:1|V:1|G:1|H:1|N:1 0 5 4 brca:1|stad:2|ucs:1|ucec:1 ENST00000371953 3 3d PTEN L25 25 2 1d5r_A(0.0) Cluster-exclusive V:1|F:2 0 3 2 gbm:2|lgg:1 ENST00000371953 3 3d PTEN I33 33 2 1d5r_A(0.0) Cluster-exclusive S:1 0 1 1 ucec:1 ENST00000371953 3 3d PTEN G36 36 2 1d5r_A(0.0) Hotspot-linked R:2|E:1 0 3 1 gbm:3 ENST00000371953 3 3d PTEN P38 38 2 1d5r_A(0.0) Cluster-exclusive S:3|F:1|L:1 0 5 2 ucs:1|skcm:4 ENST00000371953 3 3d PTEN N48 48 2 1d5r_A(0.0) Cluster-exclusive I:1|K:1 0 2 2 brca:1|prad:1 ENST00000371953 3 3d PTEN A121 121 2 1d5r_A(0.0) Cluster-exclusive T:1 0 1 1 lgg:1 ENST00000371953 3 3d PTEN A126 126 2 1d5r_A(0.0) Hotspot-linked S:1|D:2|V:1|G:1 0 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN R159 159 2 1d5r_A(0.0) Hotspot-linked S:1|K:1 0 2 1 gbm:2 ENST00000371953 3 3d PTPN11 A72 72 3 2shp_A(0.0) Hotspot T:3|D:2|V:2 0 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 3 2shp_A(0.0) Hotspot A:2|G:1|K:4 0 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 F285 285 3 2shp_A(0.0) Hotspot-linked S:1|V:1 0 2 2 all:1|gbm:1 ENST00000351677 2 3d PTPN11 N308 308 3 2shp_A(0.0) Hotspot-linked S:1|D:1 0 2 2 gbm:1|lgg:1 ENST00000351677 2 3d PTPN11 S502 502 3 2shp_A(0.0) Hotspot-linked P:1|L:1 0 2 2 gbm:1|laml:1 ENST00000351677 2 3d PTPN11 M504 504 3 2shp_A(0.0) Hotspot-linked I:1 0 1 1 luad:1 ENST00000351677 2 3d PTPN11 Q506 506 3 2shp_A(0.0) Hotspot-linked P:1 0 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 3 2shp_A(0.0) Hotspot-linked K:2 0 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 3 2shp_A(0.0) Hotspot E:1|H:3|L:3 0 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d PTPN11 F71 71 4 4dgp_A(0.0) Hotspot-linked L:3 0 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 I282 282 4 4dgp_A(0.0) Hotspot-linked M:1 0 1 1 gbm:1 ENST00000351677 2 3d ITGA1 Q303 303 5 1pt6_B(0.0) Cluster-exclusive E:1 0 1 1 prad:1 ENST00000282588 6 3d ITGA1 R304 304 5 1pt6_B(0.0) Cluster-exclusive Q:1 0 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 5 1pt6_B(0.0) Cluster-exclusive F:1 0 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 5 1pt6_B(0.0) Cluster-exclusive S:1 0 1 1 mcl:1 ENST00000282588 6 3d ITGA1 E333 333 5 1pt6_B(0.0) Cluster-exclusive G:1|K:1 0 2 2 skcm:1|lihc:1 ENST00000282588 6 3d ITGA1 E336 336 5 1pt6_B(0.0) Cluster-exclusive K:1 0 1 1 cscc:1 ENST00000282588 6 3d ITGA1 H338 338 5 1pt6_B(0.0) Cluster-exclusive P:1 0 1 1 paad:1 ENST00000282588 6 3d ITGA1 F339 339 5 1pt6_B(0.0) Cluster-exclusive L:1 0 1 1 coadread:1 ENST00000282588 6 3d ITGA1 R358 358 5 1pt6_B(0.0) Cluster-exclusive S:1 0 1 1 hnsc:1 ENST00000282588 6 3d ITGA1 A364 364 5 1pt6_B(0.0) Cluster-exclusive S:1 0 1 1 luad:1 ENST00000282588 6 3d H3C10 A2 2 6 3uee_D(0.0);3uef_B(0.0);3uee_B(0.0);3o37_H(0.069);3o37_G(0.0713);3zvy_D(0.0);3zvy_C(0.0);3o37_F(0.0703);2kft_B(0.0225);3o37_E(0.0677) Cluster-exclusive S:1|V:1|G:1 0 3 3 acc:1|brca:1|mmyl:1 ENST00000369163 2 3d H3C10 T4 4 6 3uee_D(0.0);3uef_B(0.0);3uee_B(0.0);3o37_H(0.069);3o37_G(0.0713);3zvy_D(0.0);3zvy_C(0.0);3o37_F(0.0703);2kft_B(0.0225);3o37_E(0.0677) Cluster-exclusive A:1 0 1 1 lusm:1 ENST00000369163 2 3d H3C10 K5 5 6 3uee_D(0.0);3uef_B(0.0);3uee_B(0.0);3o37_H(0.069);3o37_G(0.0713);3zvy_D(0.0);3zvy_C(0.0);3o37_F(0.0703);2kft_B(0.0225);3o37_E(0.0677) Cluster-exclusive M:1 0 1 1 hnsc:1 ENST00000369163 2 3d H3C10 Q6 6 6 3uee_D(0.0);3uef_B(0.0);3uee_B(0.0);3o37_H(0.069);3o37_G(0.0713);3zvy_D(0.0);3zvy_C(0.0);3o37_F(0.0703);2kft_B(0.0225);3o37_E(0.0677) Cluster-exclusive H:2 0 2 2 hnsc:1|luad:1 ENST00000369163 2 3d H4C12 S2 2 8 4m38_E(0.0) Cluster-exclusive C:1 0 1 1 prad:1 ENST00000357549 2 3d H4C12 G3 3 8 4m38_E(0.0) Cluster-exclusive A:1 0 1 1 esca:1 ENST00000357549 2 3d H4C12 G5 5 8 4m38_E(0.0) Cluster-exclusive S:1 0 1 1 luad:1 ENST00000357549 2 3d H4C11 G3 3 9 4m38_E(0.0) Cluster-exclusive S:1 0 1 1 lihc:1 ENST00000355057 1 3d H4C11 R4 4 9 4m38_E(0.0) Cluster-exclusive G:1 0 1 1 thca:1 ENST00000355057 1 3d H4C11 G5 5 9 4m38_E(0.0) Cluster-exclusive D:1 0 1 1 lihc:1 ENST00000355057 1 3d H4C13 S2 2 10 4m38_E(0.0) Cluster-exclusive C:1 0 1 1 esca:1 ENST00000355981 2 3d H4C13 G3 3 10 4m38_E(0.0) Cluster-exclusive E:1 0 1 1 skcm:1 ENST00000355981 2 3d H4C13 R4 4 10 4m38_E(0.0) Cluster-exclusive C:1 0 1 1 brca:1 ENST00000355981 2 3d SPOP Y87 87 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot S:2|C:1|N:2 0.0001 5 1 prad:5 ENST00000347630 2 3d SPOP F102 102 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot C:2|V:2|L:1 0.0001 5 1 prad:5 ENST00000347630 2 3d SPOP F125 125 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked L:1 0.0001 1 1 prad:1 ENST00000347630 2 3d SPOP K129 129 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked E:1 0.0001 1 1 prad:1 ENST00000347630 2 3d SPOP D130 130 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked H:1|N:1 0.0001 2 2 prad:1|cll:1 ENST00000347630 2 3d SPOP W131 131 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot R:1|S:1|C:1|G:4 0.0001 7 2 prad:6|ucec:1 ENST00000347630 2 3d SPOP F133 133 12 3hqm_B(0.0055);3ivb_A(0.0059);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);2cr2_A(0.0091);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);4o1v_A(0.004);3ivq_B(0.0051);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot S:3|C:4|V:4|I:2|L:9 0.0001 22 1 prad:22 ENST00000347630 2 3d SPOP F104 104 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked S:1|I:1 0.0001 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked V:4 0.0001 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked R:1|N:1 0.0001 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP K134 134 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot-linked N:1 0.0001 1 1 prad:1 ENST00000347630 2 3d PTEN K125 125 16 1d5r_A(1.0E-4) Hotspot-linked T:1|N:1 0.0001 2 2 coadread:1|kirc:1 ENST00000371953 3 3d PPP2R1A P179 179 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot R:12|L:1 0.0003 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked W:1 0.0003 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot Q:4|W:14|G:1 0.0003 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A D215 215 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked H:1 0.0003 1 1 lusc:1 ENST00000322088 6 3d PPP2R1A Q217 217 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked K:1 0.0003 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A S219 219 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked L:3 0.0003 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked M:1 0.0003 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A R221 221 17 2nyl_A(0.0015);3dw8_D(6.0E-4);2nym_A(0.001);3dw8_A(5.0E-4);2nym_D(9.0E-4);4i5l_D(6.0E-4);4i5n_A(9.0E-4);2nyl_D(5.0E-4);4i5n_D(8.0E-4);4i5l_A(7.0E-4);2npp_D(6.0E-4);2iae_A(5.0E-4);2ie4_A(7.0E-4);2pf4_B(5.0E-4);2pf4_A(7.0E-4);2npp_A(0.0013);1b3u_B(6.0E-4);1b3u_A(5.0E-4);2ie3_A(6.0E-4);2pkg_A(4.0E-4);2pkg_B(9.0E-4);3fga_A(9.0E-4);2pf4_C(3.0E-4);3k7v_A(4.0E-4);3k7w_A(6.0E-4) Hotspot-linked W:2 0.0003 2 2 stad:1|ucec:1 ENST00000322088 6 3d CENPE L126 126 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive I:1 0.0003 1 1 ucec:1 ENST00000265148 3 3d CENPE R128 128 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive C:1 0.0003 1 1 stad:1 ENST00000265148 3 3d CENPE V129 129 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive A:1|L:1 0.0003 2 2 lihc:1|luad:1 ENST00000265148 3 3d CENPE S130 130 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive F:1 0.0003 1 1 skcm:1 ENST00000265148 3 3d CENPE E170 170 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive K:2 0.0003 2 2 brca:1|coadread:1 ENST00000265148 3 3d CENPE M209 209 18 1t5c_A(3.0E-4);1t5c_B(8.0E-4) Cluster-exclusive V:1 0.0003 1 1 lihc:1 ENST00000265148 3 3d BRAF G464 464 19 4g9c_B(4.0E-4) Hotspot-linked V:2 0.0004 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 19 4g9c_B(4.0E-4) Hotspot A:1|E:6|V:10 0.0004 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 19 4g9c_B(4.0E-4) Hotspot-linked L:2 0.0004 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 19 4g9c_B(4.0E-4) Hotspot A:9|R:3|S:1|E:2|V:6 0.0004 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 19 4g9c_B(4.0E-4) Hotspot-linked I:1 0.0004 1 1 paad:1 ENST00000288602 6 3d BRAF F595 595 19 4g9c_B(4.0E-4) Hotspot-linked L:1 0.0004 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 19 4g9c_B(4.0E-4) Hotspot R:2|S:1|D:1|V:1 0.0004 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 19 4g9c_B(4.0E-4) Hotspot Q:2|R:1|S:1 0.0004 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 19 4g9c_B(4.0E-4) Hotspot R:4|E:509|K:32 0.0004 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d ZNF98 C492 492 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive F:1 0.0005 1 1 luad:1 ENST00000357774 5 3d ZNF98 E493 493 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive G:1 0.0005 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive Q:1 0.0005 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive A:1|D:1 0.0005 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive I:1 0.0005 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive T:1 0.0005 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive V:1 0.0005 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive T:1 0.0005 1 1 coadread:1 ENST00000357774 5 3d ZNF98 Q501 501 20 3brt_B(5.0E-4);3brt_D(9.0E-4);3brv_D(0.0011) Cluster-exclusive K:1 0.0005 1 1 npc:1 ENST00000357774 5 3d TP53 R273 273 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot P:4|C:119|S:5|H:103|L:22 0.0006 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 C275 275 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot R:1|S:4|F:10|Y:15 0.0006 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d TP53 C277 277 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot-linked F:5|G:1 0.0006 6 5 mmyl:1|blca:1|hnsc:1|ov:1|luad:2 ENST00000269305 4 3d TP53 P278 278 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot A:5|R:5|S:11|T:6|H:3|L:7 0.0006 37 13 brca:4|mmyl:1|paad:1|coadread:5|esca:2|hnsc:7|ov:5|lusc:4|lgg:1|skcm:2|ucec:1|cscc:2|luad:2 ENST00000269305 4 3d TP53 G279 279 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot-linked R:1|E:4 0.0006 5 4 brca:1|blca:1|ov:1|cscc:2 ENST00000269305 4 3d TP53 R280 280 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot S:4|T:10|G:6|I:5|K:15 0.0006 40 17 brca:3|npc:1|esca:1|ucs:1|blca:7|hnsc:7|laml:1|ov:2|lihc:2|lusc:1|lgg:3|lusm:1|stad:1|skcm:2|cesc:1|luad:5|cscc:1 ENST00000269305 4 3d TP53 D281 281 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot P:1|A:1|E:4|V:4|G:1|H:2|Y:8|N:7 0.0006 28 16 brca:3|mmyl:1|paad:1|cll:1|ucs:1|blca:1|hnsc:1|ov:4|lihc:1|lusc:1|stad:1|gbm:3|nbl:1|ucec:1|kirc:1|luad:6 ENST00000269305 4 3d TP53 R282 282 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot P:1|Q:2|W:83|G:4 0.0006 90 19 paad:9|brca:1|coadread:21|esca:7|blca:1|hnsc:14|ov:6|lihc:1|lusc:2|lymbc:1|lgg:4|kich:1|prad:1|stad:9|gbm:5|skcm:2|ucec:1|cscc:1|luad:3 ENST00000269305 4 3d TP53 R283 283 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot-linked P:7|H:1 0.0006 8 4 paad:1|hnsc:4|lusc:1|luad:2 ENST00000269305 4 3d TP53 T284 284 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot-linked P:1 0.0006 1 1 lusc:1 ENST00000269305 4 3d TP53 E285 285 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot-linked V:2|K:20 0.0006 22 9 brca:4|npc:1|lusm:1|prad:1|stad:2|blca:7|hnsc:2|cesc:2|luad:2 ENST00000269305 4 3d TP53 E286 286 22 1hu8_A(0.0013);2ioo_A(9.0E-4);2p52_A(6.0E-4);2iom_A(6.0E-4);2ioi_A(7.0E-4);2geq_A(6.0E-4) Hotspot A:1|Q:3|V:1|G:4|K:17 0.0006 26 12 brca:5|coadread:2|stad:3|esca:1|hnsc:2|laml:1|ov:1|skcm:2|lihc:2|lgg:1|cscc:2|luad:4 ENST00000269305 4 3d ZNF98 L362 362 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive F:1 0.0006 1 1 hnsc:1 ENST00000357774 5 3d ZNF98 S363 363 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive F:1 0.0006 1 1 skcm:1 ENST00000357774 5 3d ZNF98 H364 364 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive Y:1 0.0006 1 1 skcm:1 ENST00000357774 5 3d ZNF98 T366 366 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive A:1|N:1 0.0006 2 2 skcm:1|luad:1 ENST00000357774 5 3d ZNF98 T367 367 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive I:1 0.0006 1 1 ucec:1 ENST00000357774 5 3d ZNF98 K369 369 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive T:1 0.0006 1 1 stad:1 ENST00000357774 5 3d ZNF98 R370 370 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive I:3|K:1 0.0006 4 2 skcm:1|ucec:3 ENST00000357774 5 3d ZNF98 R398 398 23 1y6k_R(6.0E-4);1y6m_R(0.0011) Cluster-exclusive I:1 0.0006 1 1 ucec:1 ENST00000357774 5 3d CDK4 A10 10 24 3g33_C(0.0138);2w99_B(0.0136);2w9z_B(0.0155);2w96_B(0.0141);3g33_A(0.0137);2w9f_B(7.0E-4) Hotspot-linked 0.0007 1 ENST00000257904 6 3d CDK4 K22 22 24 3g33_C(0.0138);2w99_B(0.0136);2w9z_B(0.0155);2w96_B(0.0141);3g33_A(0.0137);2w9f_B(7.0E-4) Hotspot Q:2|M:2 0.0007 4 2 mmyl:1|skcm:3 ENST00000257904 6 3d CDK4 A23 23 24 3g33_C(0.0138);2w99_B(0.0136);2w9z_B(0.0155);2w96_B(0.0141);3g33_A(0.0137);2w9f_B(7.0E-4) Hotspot-linked S:1 0.0007 1 1 luad:1 ENST00000257904 6 3d CDK4 R24 24 24 3g33_C(0.0138);2w99_B(0.0136);2w9z_B(0.0155);2w96_B(0.0141);3g33_A(0.0137);2w9f_B(7.0E-4) Hotspot C:2|S:1|H:2|L:5 0.0007 10 3 mmyl:1|skcm:6|luad:3 ENST00000257904 6 3d CDK4 F31 31 24 3g33_C(0.0138);2w99_B(0.0136);2w9z_B(0.0155);2w96_B(0.0141);3g33_A(0.0137);2w9f_B(7.0E-4) Hotspot-linked C:1 0.0007 1 1 prad:1 ENST00000257904 6 3d FOXA1 I176 176 25 1vtn_C(9.0E-4) Hotspot V:3|M:4 0.0009 7 2 brca:6|luad:1 ENST00000250448 2 3d FOXA1 D226 226 25 1vtn_C(9.0E-4) Hotspot-linked G:1|N:4 0.0009 5 3 brca:3|prad:1|blca:1 ENST00000250448 2 3d FOXA1 C227 227 25 1vtn_C(9.0E-4) Hotspot-linked R:1 0.0009 1 1 prad:1 ENST00000250448 2 3d FOXA1 V229 229 25 1vtn_C(9.0E-4) Hotspot-linked I:1 0.0009 1 1 ucec:1 ENST00000250448 2 3d FOXA1 H247 247 25 1vtn_C(9.0E-4) Hotspot-linked Q:1|Y:2 0.0009 3 2 brca:2|prad:1 ENST00000250448 2 3d FOXA1 S250 250 25 1vtn_C(9.0E-4) Hotspot-linked F:3 0.0009 3 1 brca:3 ENST00000250448 2 3d FOXA1 M253 253 25 1vtn_C(9.0E-4) Hotspot-linked R:1|T:1|K:1 0.0009 3 1 prad:3 ENST00000250448 2 3d SHROOM4 P176 176 26 2xky_I(0.001) Cluster-exclusive H:1 0.001 1 1 ucec:1 ENST00000289292 7 3d SHROOM4 Q253 253 26 2xky_I(0.001) Cluster-exclusive E:1 0.001 1 1 hnsc:1 ENST00000289292 7 3d SHROOM4 M254 254 26 2xky_I(0.001) Cluster-exclusive I:1 0.001 1 1 lgg:1 ENST00000289292 7 3d SHROOM4 G261 261 26 2xky_I(0.001) Cluster-exclusive R:1 0.001 1 1 coadread:1 ENST00000289292 7 3d TP53 A276 276 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked P:3|D:2|G:1 0.0011 6 6 brca:1|esca:1|hnsc:1|ov:1|lihc:1|luad:1 ENST00000269305 4 3d STIM1 H72 72 29 2k60_A(0.0011) Cluster-exclusive R:1 0.0011 1 1 luad:1 ENST00000300737 4 3d STIM1 D78 78 29 2k60_A(0.0011) Cluster-exclusive G:1 0.0011 1 1 skcm:1 ENST00000300737 4 3d STIM1 D82 82 29 2k60_A(0.0011) Cluster-exclusive N:1 0.0011 1 1 cscc:1 ENST00000300737 4 3d STIM1 V83 83 29 2k60_A(0.0011) Cluster-exclusive A:1 0.0011 1 1 skcm:1 ENST00000300737 4 3d STIM1 L92 92 29 2k60_A(0.0011) Cluster-exclusive P:1 0.0011 1 1 stad:1 ENST00000300737 4 3d STIM1 K113 113 29 2k60_A(0.0011) Cluster-exclusive R:1 0.0011 1 1 lihc:1 ENST00000300737 4 3d STIM1 S116 116 29 2k60_A(0.0011) Cluster-exclusive N:1 0.0011 1 1 gbm:1 ENST00000300737 4 3d PTEN C71 71 30 1d5r_A(0.0013) Hotspot-linked Y:3 0.0013 3 2 gbm:2|ucec:1 ENST00000371953 3 3d BRAF D594 594 31 4wo5_A(0.0013) Hotspot G:6|H:1|N:5 0.0013 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF K601 601 31 4wo5_A(0.0013) Hotspot T:1|E:12|N:2 0.0013 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PTPN11 T468 468 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot-linked M:5 0.0013 5 3 coadread:1|stad:2|skcm:2 ENST00000351677 2 3d BRAF N581 581 33 4dbn_B(0.0014) Hotspot S:7|T:2|H:1|I:1 0.0014 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d SMAD4 H92 92 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive Y:1 0.0015 1 1 cesc:1 ENST00000342988 3 3d SMAD4 L109 109 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive Q:1|R:1 0.0015 2 2 brca:1|paad:1 ENST00000342988 3 3d SMAD4 C115 115 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive Y:1 0.0015 1 1 coadread:1 ENST00000342988 3 3d SMAD4 A118 118 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive V:1 0.0015 1 1 hnsc:1 ENST00000342988 3 3d SMAD4 C127 127 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive S:1 0.0015 1 1 paad:1 ENST00000342988 3 3d SMAD4 P130 130 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive L:1 0.0015 1 1 paad:1 ENST00000342988 3 3d SMAD4 Y131 131 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive C:1 0.0015 1 1 paad:1 ENST00000342988 3 3d SMAD4 H132 132 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive Y:2 0.0015 2 1 brca:2 ENST00000342988 3 3d SMAD4 Y133 133 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive N:1 0.0015 1 1 blca:1 ENST00000342988 3 3d SMAD4 E134 134 34 3qsv_C(0.0017);3qsv_D(0.002);3qsv_A(0.0015) Cluster-exclusive K:1 0.0015 1 1 coadread:1 ENST00000342988 3 3d PTPN11 G60 60 35 2shp_A(0.0016) Hotspot-linked V:1 0.0016 1 1 laml:1 ENST00000351677 2 3d PTPN11 D61 61 35 2shp_A(0.0016) Hotspot-linked Y:1|N:1 0.0016 2 2 laml:1|nbl:1 ENST00000351677 2 3d PTPN11 R512 512 35 2shp_A(0.0016) Hotspot-linked Q:1 0.0016 1 1 coadread:1 ENST00000351677 2 3d SMAD4 D351 351 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot A:1|G:3|H:2|Y:2 0.0017 8 6 paad:2|coadread:2|prad:1|stad:1|esca:1|luad:1 ENST00000342988 3 3d SMAD4 G352 352 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked A:1|R:1 0.0017 2 2 coadread:1|stad:1 ENST00000342988 3 3d SMAD4 Y353 353 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked N:1 0.0017 1 1 prad:1 ENST00000342988 3 3d SMAD4 R361 361 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot P:1|C:18|G:2|H:20 0.0017 41 8 brca:1|paad:8|coadread:20|stad:5|esca:3|hnsc:1|cesc:2|luad:1 ENST00000342988 3 3d SMAD4 C363 363 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked Y:1 0.0017 1 1 stad:1 ENST00000342988 3 3d SMAD4 G365 365 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked R:1|D:1 0.0017 2 1 coadread:2 ENST00000342988 3 3d SMAD4 I383 383 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked R:1 0.0017 1 1 stad:1 ENST00000342988 3 3d SMAD4 G384 384 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot-linked D:1 0.0017 1 1 paad:1 ENST00000342988 3 3d SMAD4 G386 386 37 1dd1_C(0.0038);1g88_C(0.0045);1g88_B(0.0022);1dd1_B(0.0017) Hotspot A:1|S:1|C:1|D:5|V:3 0.0017 11 6 paad:1|coadread:3|prad:1|stad:2|esca:3|luad:1 ENST00000342988 3 3d SNAP29 S78 78 38 4wy4_C(0.0017) Cluster-exclusive F:1 0.0017 1 1 skcm:1 ENST00000215730 7 3d SNAP29 E79 79 38 4wy4_C(0.0017) Cluster-exclusive K:1 0.0017 1 1 blca:1 ENST00000215730 7 3d SNAP29 A82 82 38 4wy4_C(0.0017) Cluster-exclusive T:1 0.0017 1 1 paad:1 ENST00000215730 7 3d SNAP29 R83 83 38 4wy4_C(0.0017) Cluster-exclusive C:1 0.0017 1 1 skcm:1 ENST00000215730 7 3d SNAP29 G86 86 38 4wy4_C(0.0017) Cluster-exclusive A:1 0.0017 1 1 blca:1 ENST00000215730 7 3d FLNA V875 875 39 1wim_A(0.0018) Cluster-exclusive M:1 0.0018 1 1 skcm:1 ENST00000369850 3 3d FLNA A877 877 39 1wim_A(0.0018) Cluster-exclusive V:1 0.0018 1 1 ucec:1 ENST00000369850 3 3d FLNA E878 878 39 1wim_A(0.0018) Cluster-exclusive K:2 0.0018 2 2 brca:1|hnsc:1 ENST00000369850 3 3d FLNA P880 880 39 1wim_A(0.0018) Cluster-exclusive T:1 0.0018 1 1 luad:1 ENST00000369850 3 3d FLNA G881 881 39 1wim_A(0.0018) Cluster-exclusive S:1 0.0018 1 1 paad:1 ENST00000369850 3 3d FLNA R884 884 39 1wim_A(0.0018) Cluster-exclusive H:1 0.0018 1 1 coadread:1 ENST00000369850 3 3d FLNA A899 899 39 1wim_A(0.0018) Cluster-exclusive S:1 0.0018 1 1 luad:1 ENST00000369850 3 3d RBBP7 V297 297 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive L:1 0.002 1 1 ov:1 ENST00000380087 2 3d RBBP7 E313 313 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive K:2 0.002 2 1 coadread:2 ENST00000380087 2 3d RBBP7 S314 314 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive Y:1 0.002 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive Y:1 0.002 1 1 skcm:1 ENST00000380087 2 3d RBBP7 D317 317 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive N:1 0.002 1 1 cesc:1 ENST00000380087 2 3d RBBP7 G336 336 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive D:1 0.002 1 1 stad:1 ENST00000380087 2 3d RBBP7 R340 340 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive C:1|H:2 0.002 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 40 3gfc_A(0.0021);2xu7_B(0.002);3cfv_A(0.0039);3cfv_B(0.0028) Cluster-exclusive T:1|H:1 0.002 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d PPP3CA G89 89 41 4f0z_A(0.002) Cluster-exclusive V:1 0.002 1 1 kirp:1 ENST00000394854 3 3d PPP3CA H151 151 41 4f0z_A(0.002) Cluster-exclusive Y:2|N:1 0.002 3 2 coadread:1|skcm:2 ENST00000394854 3 3d PPP3CA W232 232 41 4f0z_A(0.002) Cluster-exclusive C:1 0.002 1 1 mmyl:1 ENST00000394854 3 3d PPP3CA R279 279 41 4f0z_A(0.002) Cluster-exclusive Q:1 0.002 1 1 stad:1 ENST00000394854 3 3d PPP3CA H281 281 41 4f0z_A(0.002) Cluster-exclusive Y:1 0.002 1 1 stad:1 ENST00000394854 3 3d PPP3CA E282 282 41 4f0z_A(0.002) Cluster-exclusive D:1|K:1 0.002 2 2 brca:1|cesc:1 ENST00000394854 3 3d PPP3CA I305 305 41 4f0z_A(0.002) Cluster-exclusive F:1 0.002 1 1 prad:1 ENST00000394854 3 3d C2 S266 266 42 2odq_A(0.002) Cluster-exclusive L:1 0.002 1 1 paad:1 ENST00000299367 5 3d C2 E267 267 42 2odq_A(0.002) Cluster-exclusive K:1 0.002 1 1 skcm:1 ENST00000299367 5 3d C2 L271 271 42 2odq_A(0.002) Cluster-exclusive V:1 0.002 1 1 cesc:1 ENST00000299367 5 3d C2 K274 274 42 2odq_A(0.002) Cluster-exclusive E:1 0.002 1 1 lusc:1 ENST00000299367 5 3d C2 E275 275 42 2odq_A(0.002) Cluster-exclusive K:1 0.002 1 1 skcm:1 ENST00000299367 5 3d PPP2R1A A185 185 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot-linked T:1 0.0023 1 1 coadread:1 ENST00000322088 6 3d HRAS A11 11 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot-linked D:1 0.0024 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0024 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot R:11|C:2|S:1|D:2|V:9 0.0024 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS T58 58 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot-linked I:1 0.0024 1 1 cscc:1 ENST00000451590 1 3d HRAS A59 59 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot-linked T:1 0.0024 1 1 ucec:1 ENST00000451590 1 3d HRAS G60 60 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot-linked S:1 0.0024 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 44 3tgp_A(0.0045);6q21_D(0.0024) Hotspot R:19|H:2|K:10|L:9 0.0024 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d PTPN11 E69 69 45 1ayc_A(0.003);4je4_A(0.0025);3tl0_A(0.0025) Hotspot-linked D:1|K:3 0.0025 4 3 coadread:2|gbm:1|pias:1 ENST00000351677 2 3d PPP2R1A T145 145 47 4i5n_D(0.0027) Hotspot-linked P:1 0.0027 1 1 ov:1 ENST00000322088 6 3d AMY1C H314 314 48 4gqq_A(0.0027) Cluster-exclusive Y:1 0.0027 1 1 coadread:1 ENST00000370079 3 3d AMY1C S326 326 48 4gqq_A(0.0027) Cluster-exclusive Y:1 0.0027 1 1 luad:1 ENST00000370079 3 3d AMY1C I327 327 48 4gqq_A(0.0027) Cluster-exclusive T:1 0.0027 1 1 luad:1 ENST00000370079 3 3d AMY1C D332 332 48 4gqq_A(0.0027) Cluster-exclusive N:1 0.0027 1 1 lusc:1 ENST00000370079 3 3d FBXW7 S426 426 49 2ovr_B(0.0028);2ovq_B(0.0035);2ovp_B(0.0053) Hotspot-linked L:1 0.0028 1 1 blca:1 ENST00000281708 4 3d FBXW7 V464 464 49 2ovr_B(0.0028);2ovq_B(0.0035);2ovp_B(0.0053) Hotspot-linked E:1 0.0028 1 1 luad:1 ENST00000281708 4 3d FBXW7 R465 465 49 2ovr_B(0.0028);2ovq_B(0.0035);2ovp_B(0.0053) Hotspot P:1|C:33|G:1|H:26|L:1 0.0028 62 14 acc:1|brca:2|coadread:23|cll:1|esca:1|ucs:7|hnsc:2|ov:1|lusc:1|stad:10|mbl:1|ucec:7|cesc:4|luad:1 ENST00000281708 4 3d FBXW7 R479 479 49 2ovr_B(0.0028);2ovq_B(0.0035);2ovp_B(0.0053) Hotspot P:2|Q:13|G:2|L:2 0.0028 19 11 brca:1|coadread:1|stad:3|gbm:1|ucs:3|blca:1|hnsc:3|skcm:1|ucec:1|cesc:3|kirp:1 ENST00000281708 4 3d FBXW7 R505 505 49 2ovr_B(0.0028);2ovq_B(0.0035);2ovp_B(0.0053) Hotspot C:16|S:1|G:19|H:2|L:2 0.0028 40 12 coadread:8|cll:1|stad:1|esca:1|ucs:3|blca:4|hnsc:7|ov:1|skcm:2|ucec:6|lusc:3|cesc:3 ENST00000281708 4 3d PTEN I28 28 50 1d5r_A(0.003) Hotspot-linked S:1|F:1|M:1 0.003 3 3 brca:1|coadread:1|stad:1 ENST00000371953 3 3d PTEN L152 152 50 1d5r_A(0.003) Hotspot-linked P:1|R:1 0.003 2 2 lusm:1|ucec:1 ENST00000371953 3 3d PTEN G165 165 50 1d5r_A(0.003) Hotspot-linked R:3|E:4 0.003 7 5 coadread:1|lusm:1|mbl:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN V166 166 50 1d5r_A(0.003) Hotspot-linked I:1 0.003 1 1 lihc:1 ENST00000371953 3 3d SPOP K103 103 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked N:1 0.0031 1 1 ucec:1 ENST00000347630 2 3d KRAS G12 12 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0032 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot A:1|R:1|C:12|D:75|V:2 0.0032 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS P34 34 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot-linked L:1 0.0032 1 1 coadread:1 ENST00000311936 3 3d KRAS A59 59 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot-linked T:1|E:1|G:3 0.0032 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot D:1 0.0032 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0032 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot-linked G:1|K:1 0.0032 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot-linked K:2 0.0032 2 2 mmyl:1|pias:1 ENST00000311936 3 3d KRAS Y64 64 54 3rs4_A(0.0057);3rs2_A(0.0049);3rs3_A(0.0052);3rs7_A(0.0038);3v4f_A(0.0051);3l8y_A(0.0044);4dls_A(0.004);3rrz_A(0.0048);4dlv_A(0.0032);4dlx_A(0.0046);4dly_A(0.0045);4dlz_A(0.0052);4dlr_A(0.0042);3rs0_A(0.0054);3rso_A(0.0041) Hotspot-linked D:1|H:1|N:1 0.0032 3 2 mmyl:2|coadread:1 ENST00000311936 3 3d KDM4B V172 172 55 4lxl_A(0.0033) Cluster-exclusive A:1 0.0033 1 1 hnsc:1 ENST00000159111 4 3d KDM4B E191 191 55 4lxl_A(0.0033) Cluster-exclusive K:1 0.0033 1 1 stad:1 ENST00000159111 4 3d KDM4B L195 195 55 4lxl_A(0.0033) Cluster-exclusive Q:1 0.0033 1 1 cesc:1 ENST00000159111 4 3d KDM4B Y196 196 55 4lxl_A(0.0033) Cluster-exclusive H:1 0.0033 1 1 stad:1 ENST00000159111 4 3d KDM4B S197 197 55 4lxl_A(0.0033) Cluster-exclusive N:1 0.0033 1 1 ucec:1 ENST00000159111 4 3d KDM4B P273 273 55 4lxl_A(0.0033) Cluster-exclusive S:1 0.0033 1 1 skcm:1 ENST00000159111 4 3d KDM4B F292 292 55 4lxl_A(0.0033) Cluster-exclusive V:1 0.0033 1 1 esca:1 ENST00000159111 4 3d KDM4B A293 293 55 4lxl_A(0.0033) Cluster-exclusive T:1 0.0033 1 1 coadread:1 ENST00000159111 4 3d KRAS A11 11 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked T:1 0.0034 1 1 paad:1 ENST00000311936 3 3d KRAS R68 68 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked S:1|M:1 0.0034 2 2 coadread:1|lihc:1 ENST00000311936 3 3d PTEN H93 93 57 1d5r_A(0.0034) Hotspot-linked R:3|Y:2|L:1 0.0034 6 6 brca:1|coadread:1|gbm:1|mbl:1|hnsc:1|ucec:1 ENST00000371953 3 3d PTEN P95 95 57 1d5r_A(0.0034) Hotspot-linked L:1 0.0034 1 1 gbm:1 ENST00000371953 3 3d PTEN T167 167 57 1d5r_A(0.0034) Hotspot-linked S:1 0.0034 1 1 gbm:1 ENST00000371953 3 3d PTEN S170 170 57 1d5r_A(0.0034) Hotspot-linked N:4 0.0034 4 3 gbm:2|ucec:1|kirc:1 ENST00000371953 3 3d PTEN Q171 171 57 1d5r_A(0.0034) Hotspot-linked K:1 0.0034 1 1 lusc:1 ENST00000371953 3 3d PTEN R173 173 57 1d5r_A(0.0034) Hotspot-linked C:5|H:5 0.0034 10 5 coadread:1|prad:1|gbm:5|ucec:2|lgg:1 ENST00000371953 3 3d PTEN Y174 174 57 1d5r_A(0.0034) Hotspot-linked D:1 0.0034 1 1 skcm:1 ENST00000371953 3 3d PTEN V175 175 57 1d5r_A(0.0034) Hotspot-linked A:1|E:1|L:1 0.0034 3 3 ov:1|lihc:1|luad:1 ENST00000371953 3 3d TP53 L330 330 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive P:1|R:1 0.0037 2 2 skcm:1|lihc:1 ENST00000269305 4 3d TP53 Q331 331 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive H:7 0.0037 7 6 paad:1|coadread:1|hnsc:2|ov:1|lusc:1|luad:1 ENST00000269305 4 3d TP53 R333 333 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive P:1 0.0037 1 1 stad:1 ENST00000269305 4 3d TP53 G334 334 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive A:1|V:3|W:1 0.0037 5 2 stad:1|luad:4 ENST00000269305 4 3d TP53 R337 337 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive P:2|C:18|S:2|H:4|L:9 0.0037 35 16 acc:1|brca:2|paad:2|coadread:5|esca:1|hnsc:5|laml:1|ov:1|lihc:1|lusc:2|lgg:1|kich:1|prad:1|stad:2|cesc:1|luad:8 ENST00000269305 4 3d TP53 F338 338 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive I:1|L:1 0.0037 2 2 kich:1|stad:1 ENST00000269305 4 3d TP53 F341 341 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive S:1|L:1 0.0037 2 2 brca:1|hnsc:1 ENST00000269305 4 3d TP53 R342 342 59 1pet_D(0.0049);1pet_C(0.0037);1pet_B(0.0048);1pet_A(0.0043) Cluster-exclusive P:2|L:1 0.0037 3 2 brca:2|kirp:1 ENST00000269305 4 3d NGFR V71 71 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive M:1 0.0037 1 1 stad:1 ENST00000172229 3 3d NGFR T72 72 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive M:2 0.0037 2 2 paad:1|skcm:1 ENST00000172229 3 3d NGFR F73 73 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive L:1 0.0037 1 1 coadread:1 ENST00000172229 3 3d NGFR D75 75 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive N:1 0.0037 1 1 skcm:1 ENST00000172229 3 3d NGFR P85 85 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive L:2 0.0037 2 2 mbl:1|skcm:1 ENST00000172229 3 3d NGFR D104 104 60 1sg1_X(0.0037);3ij2_Y(0.0042);3ij2_X(0.0039);3buk_C(0.0044) Cluster-exclusive N:2 0.0037 2 2 acc:1|luad:1 ENST00000172229 3 3d BRAF L485 485 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot-linked S:1|Y:1 0.004 2 2 skcm:1|luad:1 ENST00000288602 6 3d AKR7L M85 85 62 2clp_I(0.004);2bp1_A(0.0043);2clp_A(0.0042) Cluster-exclusive I:1|L:1 0.004 2 2 brca:1|lgg:1 ENST00000420396 2 3d AKR7L S87 87 62 2clp_I(0.004);2bp1_A(0.0043);2clp_A(0.0042) Cluster-exclusive L:1 0.004 1 1 cscc:1 ENST00000420396 2 3d AKR7L A88 88 62 2clp_I(0.004);2bp1_A(0.0043);2clp_A(0.0042) Cluster-exclusive T:1 0.004 1 1 stad:1 ENST00000420396 2 3d AKR7L A123 123 62 2clp_I(0.004);2bp1_A(0.0043);2clp_A(0.0042) Cluster-exclusive V:2 0.004 2 2 ucec:1|cscc:1 ENST00000420396 2 3d CSF1 F67 67 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive S:1 0.004 1 1 paad:1 ENST00000329608 6 3d CSF1 F69 69 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive L:1 0.004 1 1 coadread:1 ENST00000329608 6 3d CSF1 D71 71 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive H:1 0.004 1 1 brca:1 ENST00000329608 6 3d CSF1 A85 85 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive T:1 0.004 1 1 stad:1 ENST00000329608 6 3d CSF1 L88 88 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive M:1 0.004 1 1 ucec:1 ENST00000329608 6 3d CSF1 V135 135 63 3uez_H(0.0066);4fa8_E(0.0081);3uf2_H(0.0062);3uf2_G(0.0066);3uf2_F(0.0077);3uf2_E(0.0052);3uf2_D(0.0071);3uf2_C(0.0065);3uf2_B(0.0091);4fa8_F(0.0068);3uf2_A(0.0058);4fa8_G(0.004);3uez_G(0.0063);3uez_F(0.0042);3uf2_J(0.0054);3uf2_I(0.0062) Cluster-exclusive I:1 0.004 1 1 ov:1 ENST00000329608 6 3d PAXIP1 T872 872 64 4fxk_A(0.004) Cluster-exclusive S:1 0.004 1 1 luad:1 ENST00000397192 1 3d PAXIP1 F874 874 64 4fxk_A(0.004) Cluster-exclusive L:1 0.004 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 E875 875 64 4fxk_A(0.004) Cluster-exclusive K:1 0.004 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 P876 876 64 4fxk_A(0.004) Cluster-exclusive S:1 0.004 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 K885 885 64 4fxk_A(0.004) Cluster-exclusive E:1 0.004 1 1 hnsc:1 ENST00000397192 1 3d PAXIP1 Y887 887 64 4fxk_A(0.004) Cluster-exclusive C:1 0.004 1 1 mmyl:1 ENST00000397192 1 3d PTK2B M537 537 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive I:1 0.0042 1 1 ucec:1 ENST00000346049 5 3d PTK2B H547 547 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive P:1 0.0042 1 1 luad:1 ENST00000346049 5 3d PTK2B L565 565 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive M:1 0.0042 1 1 ucec:1 ENST00000346049 5 3d PTK2B G566 566 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive R:1 0.0042 1 1 cll:1 ENST00000346049 5 3d PTK2B D567 567 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive G:1 0.0042 1 1 stad:1 ENST00000346049 5 3d PTK2B L570 570 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive F:1 0.0042 1 1 skcm:1 ENST00000346049 5 3d PTK2B S571 571 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive F:1 0.0042 1 1 skcm:1 ENST00000346049 5 3d PTK2B M610 610 69 3fzr_A(0.0044);3et7_A(0.0042) Cluster-exclusive I:1|L:1 0.0042 2 1 luad:2 ENST00000346049 5 3d EP300 G1375 1375 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked R:1 0.0043 1 1 lusm:1 ENST00000263253 7 3d EP300 H1377 1377 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked R:1 0.0043 1 1 coadread:1 ENST00000263253 7 3d EP300 S1396 1396 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked C:1 0.0043 1 1 lihc:1 ENST00000263253 7 3d EP300 Y1397 1397 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked D:1 0.0043 1 1 ucec:1 ENST00000263253 7 3d EP300 L1398 1398 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked P:1 0.0043 1 1 lusc:1 ENST00000263253 7 3d EP300 D1399 1399 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot Y:2|N:16 0.0043 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 Y1446 1446 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked C:1 0.0043 1 1 hnsc:1 ENST00000263253 7 3d EP300 R1627 1627 71 4bhw_B(0.0043);3biy_A(0.0079);4bhw_A(0.0056) Hotspot-linked Q:1|W:4 0.0043 5 5 coadread:1|stad:1|blca:1|skcm:1|luad:1 ENST00000263253 7 3d PLEKHH2 E92 92 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive K:1 0.0047 1 1 skcm:1 ENST00000282406 4 3d PLEKHH2 S93 93 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive L:2 0.0047 2 2 coadread:1|skcm:1 ENST00000282406 4 3d PLEKHH2 D99 99 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive Y:1 0.0047 1 1 coadread:1 ENST00000282406 4 3d PLEKHH2 D100 100 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive N:1 0.0047 1 1 cesc:1 ENST00000282406 4 3d PLEKHH2 V101 101 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive I:1 0.0047 1 1 coadread:1 ENST00000282406 4 3d PLEKHH2 I102 102 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive T:1 0.0047 1 1 lihc:1 ENST00000282406 4 3d PLEKHH2 Q103 103 73 4k30_B(0.0048);4k30_A(0.0053);4k30_Y(0.0047) Cluster-exclusive P:2 0.0047 2 2 coadread:1|skcm:1 ENST00000282406 4 3d IFNLR1 P27 27 74 3og6_B(0.0047);3og4_B(0.0071) Cluster-exclusive L:2 0.0047 2 2 skcm:1|luad:1 ENST00000327535 1 3d IFNLR1 T102 102 74 3og6_B(0.0047);3og4_B(0.0071) Cluster-exclusive M:1 0.0047 1 1 coadread:1 ENST00000327535 1 3d IFNLR1 S104 104 74 3og6_B(0.0047);3og4_B(0.0071) Cluster-exclusive F:1|Y:1 0.0047 2 2 ucec:1|cesc:1 ENST00000327535 1 3d IFNLR1 S107 107 74 3og6_B(0.0047);3og4_B(0.0071) Cluster-exclusive F:1 0.0047 1 1 esca:1 ENST00000327535 1 3d IFNLR1 P110 110 74 3og6_B(0.0047);3og4_B(0.0071) Cluster-exclusive T:1|L:1 0.0047 2 2 esca:1|ucec:1 ENST00000327535 1 3d PLXNB1 C1271 1271 76 1w0s_A(0.0049);1w0r_A(0.0051) Cluster-exclusive R:1 0.0049 1 1 hnsc:1 ENST00000296440 6 3d PLXNB1 V1272 1272 76 1w0s_A(0.0049);1w0r_A(0.0051) Cluster-exclusive I:1 0.0049 1 1 ucec:1 ENST00000296440 6 3d PLXNB1 R1273 1273 76 1w0s_A(0.0049);1w0r_A(0.0051) Cluster-exclusive C:1 0.0049 1 1 ucec:1 ENST00000296440 6 3d THRA R284 284 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive P:1 0.005 1 1 luad:1 ENST00000264637 4 3d THRA E285 285 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive G:1 0.005 1 1 coadread:1 ENST00000264637 4 3d THRA K288 288 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive E:1 0.005 1 1 ucec:1 ENST00000264637 4 3d THRA G291 291 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive S:1 0.005 1 1 coadread:1 ENST00000264637 4 3d THRA V294 294 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive I:2 0.005 2 1 stad:2 ENST00000264637 4 3d THRA S296 296 77 3jzb_A(0.0065);3ilz_A(0.0056);3hzf_A(0.0068);2h77_A(0.0059);1nav_A(0.0067);2h79_A(0.005) Cluster-exclusive F:1 0.005 1 1 skcm:1 ENST00000264637 4 3d TICAM1 S112 112 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive L:1 0.0051 1 1 stad:1 ENST00000248244 5 3d TICAM1 R114 114 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive W:1 0.0051 1 1 stad:1 ENST00000248244 5 3d TICAM1 A117 117 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive T:1 0.0051 1 1 hnsc:1 ENST00000248244 5 3d TICAM1 Q119 119 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive P:1 0.0051 1 1 luad:1 ENST00000248244 5 3d TICAM1 E120 120 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive D:1 0.0051 1 1 lihc:1 ENST00000248244 5 3d TICAM1 A121 121 78 4bsx_C(0.0094);2m63_A(0.021);4bsx_B(0.0101);4bsx_A(0.0099);4c0m_B(0.0051);4bsx_D(0.0096) Cluster-exclusive V:1 0.0051 1 1 stad:1 ENST00000248244 5 3d SYT14 Q317 317 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive H:1 0.0052 1 1 blca:1 ENST00000472886 1 3d SYT14 S410 410 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive Y:1 0.0052 1 1 ucec:1 ENST00000472886 1 3d SYT14 L411 411 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive V:1 0.0052 1 1 brca:1 ENST00000472886 1 3d SYT14 E412 412 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive Q:1|D:1 0.0052 2 2 esca:1|luad:1 ENST00000472886 1 3d SYT14 G414 414 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive D:1 0.0052 1 1 cscc:1 ENST00000472886 1 3d SYT14 S415 415 79 3hhc_B(0.0052);3hhc_A(0.0056) Cluster-exclusive A:1 0.0052 1 1 ov:1 ENST00000472886 1 3d SYT14 P378 378 80 3hhc_B(0.0052) Cluster-exclusive L:1 0.0052 1 1 cscc:1 ENST00000472886 1 3d RHOA L22 22 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked P:1|R:1 0.0054 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA T37 37 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked S:1|I:1 0.0054 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked C:1 0.0054 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot Q:6|K:1 0.0054 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked K:1 0.0054 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot C:7|S:2|F:1|I:1 0.0054 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked V:4 0.0054 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked G:1|Y:1|N:1 0.0054 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d RHOA T60 60 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked K:1 0.0054 1 1 stad:1 ENST00000418115 1 3d RHOA A61 61 81 1z2c_A(0.0054);1kmq_A(0.0084);1tx4_B(0.009);3kz1_E(0.0095);2gcp_A(0.0083);3msx_A(0.009);1ow3_B(0.0076);1cxz_A(0.0074);1a2b_A(0.0065);1s1c_B(0.0086);1s1c_A(0.0077) Hotspot-linked D:1|V:1 0.0054 2 2 coadread:1|stad:1 ENST00000418115 1 3d HRAS V81 81 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot-linked M:1 0.0058 1 1 gbc:1 ENST00000451590 1 3d PROCR R113 113 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive L:1 0.0062 1 1 luad:1 ENST00000216968 4 3d PROCR C114 114 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive S:1 0.0062 1 1 kirc:1 ENST00000216968 4 3d PROCR F130 130 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive L:1 0.0062 1 1 brca:1 ENST00000216968 4 3d PROCR E132 132 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive K:2 0.0062 2 2 coadread:1|stad:1 ENST00000216968 4 3d PROCR A134 134 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive D:1 0.0062 1 1 stad:1 ENST00000216968 4 3d PROCR S142 142 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive T:1 0.0062 1 1 lihc:1 ENST00000216968 4 3d PROCR R144 144 87 1lqv_A(0.0077);3jtc_A(0.0062) Cluster-exclusive Q:1|W:1 0.0062 2 2 coadread:1|cscc:1 ENST00000216968 4 3d ACP1 L14 14 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive V:1 0.0062 1 1 kirc:1 ENST00000272065 5 3d ACP1 R19 19 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive Q:1 0.0062 1 1 coadread:1 ENST00000272065 5 3d ACP1 S20 20 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive L:1 0.0062 1 1 hnsc:1 ENST00000272065 5 3d ACP1 I128 128 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive F:1 0.0062 1 1 stad:1 ENST00000272065 5 3d ACP1 E129 129 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive Q:1 0.0062 1 1 luad:1 ENST00000272065 5 3d ACP1 D130 130 88 1phr_A(0.007);1z13_A(0.007);1z12_A(0.008);1xww_A(0.0062);1dg9_A(0.0082);1pnt_A(0.0089);5pnt_A(0.0435);3n8i_A(0.0513) Cluster-exclusive E:1 0.0062 1 1 ucec:1 ENST00000272065 5 3d TP53 C238 238 89 3q06_A(0.0065) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0065 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 89 3q06_A(0.0065) Hotspot S:8|D:6|T:1 0.0065 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 89 3q06_A(0.0065) Hotspot-linked R:1|G:2 0.0065 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 89 3q06_A(0.0065) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0065 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 89 3q06_A(0.0065) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0065 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 89 3q06_A(0.0065) Hotspot-linked R:2|V:3|I:5 0.0065 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 R248 248 89 3q06_A(0.0065) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0065 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 89 3q06_A(0.0065) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0065 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 P250 250 89 3q06_A(0.0065) Hotspot-linked L:12 0.0065 12 9 paad:1|coadread:1|kich:1|stad:1|ov:2|gbc:1|lusc:1|lgg:2|luad:2 ENST00000269305 4 3d TP53 I251 251 89 3q06_A(0.0065) Hotspot-linked S:2|F:1|N:3 0.0065 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V272 272 89 3q06_A(0.0065) Hotspot E:1|G:4|K:1|L:1|M:17 0.0065 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 V274 274 89 3q06_A(0.0065) Hotspot A:4|D:5|F:7|G:4|L:1 0.0065 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d PTEN P96 96 90 1d5r_A(0.0065) Hotspot-linked A:1|T:1 0.0065 2 1 ucec:2 ENST00000371953 3 3d PTEN I101 101 90 1d5r_A(0.0065) Hotspot-linked T:1 0.0065 1 1 gbm:1 ENST00000371953 3 3d PTEN F104 104 90 1d5r_A(0.0065) Hotspot-linked I:1 0.0065 1 1 brca:1 ENST00000371953 3 3d PTEN C105 105 90 1d5r_A(0.0065) Hotspot-linked R:1|G:1|W:1|Y:2 0.0065 5 3 gbm:2|skcm:2|lgg:1 ENST00000371953 3 3d PTEN Y138 138 90 1d5r_A(0.0065) Hotspot-linked C:1 0.0065 1 1 ucec:1 ENST00000371953 3 3d H4C13 A84 84 94 1hio_D(0.0065) Cluster-exclusive T:1 0.0065 1 1 coadread:1 ENST00000355981 2 3d H4C13 M85 85 94 1hio_D(0.0065) Cluster-exclusive I:1 0.0065 1 1 brca:1 ENST00000355981 2 3d H4C13 D86 86 94 1hio_D(0.0065) Cluster-exclusive N:1 0.0065 1 1 blca:1 ENST00000355981 2 3d H4C13 V88 88 94 1hio_D(0.0065) Cluster-exclusive I:1 0.0065 1 1 mmyl:1 ENST00000355981 2 3d ZNF98 F349 349 95 1g0y_R(0.0065);1itb_B(0.0071) Cluster-exclusive L:1 0.0065 1 1 ucec:1 ENST00000357774 5 3d ZNF98 K351 351 95 1g0y_R(0.0065);1itb_B(0.0071) Cluster-exclusive I:1 0.0065 1 1 stad:1 ENST00000357774 5 3d ZNF98 C352 352 95 1g0y_R(0.0065);1itb_B(0.0071) Cluster-exclusive Y:1 0.0065 1 1 hnsc:1 ENST00000357774 5 3d ZNF98 E353 353 95 1g0y_R(0.0065);1itb_B(0.0071) Cluster-exclusive K:1 0.0065 1 1 skcm:1 ENST00000357774 5 3d TP53 V173 173 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot A:2|E:1|G:2|L:15|M:12 0.0066 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot-linked S:1|W:2|K:1 0.0066 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot C:4|G:7|H:143 0.0066 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0066 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot-linked R:2|T:1|L:3 0.0066 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0066 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot-linked D:1|K:2 0.0066 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 P190 190 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot-linked R:1|L:5 0.0066 6 6 coadread:1|kich:1|gbm:1|lihc:1|lymbc:1|lgg:1 ENST00000269305 4 3d TP53 P191 191 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot-linked L:1 0.0066 1 1 skcm:1 ENST00000269305 4 3d TP53 H193 193 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot P:7|R:32|D:2|Y:13|L:11|N:1 0.0066 66 20 brca:13|paad:2|coadread:1|cll:1|esca:3|ucs:3|blca:1|hnsc:9|laml:1|ov:8|hgg:1|lihc:4|lusc:4|lgg:4|kirp:1|lusm:1|prad:1|stad:1|ucec:2|luad:5 ENST00000269305 4 3d TP53 L194 194 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot P:2|R:15|F:3|H:3 0.0066 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot V:3|I:17|K:4 0.0066 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 G244 244 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot R:1|C:8|S:5|D:9|V:2 0.0066 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0066 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d RORC Y369 369 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive C:1 0.0066 1 1 luad:1 ENST00000318247 6 3d RORC D372 372 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive N:1 0.0066 1 1 ucec:1 ENST00000318247 6 3d RORC R374 374 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive C:2 0.0066 2 2 stad:1|ucec:1 ENST00000318247 6 3d RORC T375 375 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive M:1 0.0066 1 1 kirp:1 ENST00000318247 6 3d RORC G383 383 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive D:1 0.0066 1 1 stad:1 ENST00000318247 6 3d RORC M385 385 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive I:1 0.0066 1 1 skcm:1 ENST00000318247 6 3d RORC F401 401 97 4wlb_A(0.0085);4qm0_C(0.0085);4nie_B(0.012);4s14_A(0.0072);4nie_A(0.0105);4wpf_D(0.0106);4qm0_A(0.0102);3l0j_A(0.0073);4wpf_A(0.0113);4nb6_B(0.0075);4nb6_A(0.0087);3l0l_A(0.0076);4wlb_B(0.0068);3l0l_B(0.0105);4ymq_A(0.0066);3kyt_A(0.0106);4wqp_B(0.0067);4wqp_A(0.0105);3b0w_B(0.0121);3b0w_A(0.0131) Cluster-exclusive L:1 0.0066 1 1 skcm:1 ENST00000318247 6 3d THRA A298 298 99 1nav_A(0.0067) Cluster-exclusive T:1 0.0067 1 1 stad:1 ENST00000264637 4 3d DPYSL3 G68 68 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive A:1|E:1 0.0068 2 2 brca:1|blca:1 ENST00000398514 3 3d DPYSL3 G69 69 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive V:1 0.0068 1 1 kirc:1 ENST00000398514 3 3d DPYSL3 D71 71 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive N:2 0.0068 2 2 coadread:1|luad:1 ENST00000398514 3 3d DPYSL3 T101 101 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive I:1 0.0068 1 1 hnsc:1 ENST00000398514 3 3d DPYSL3 T102 102 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive A:1 0.0068 1 1 coadread:1 ENST00000398514 3 3d DPYSL3 R361 361 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive W:1 0.0068 1 1 brca:1 ENST00000398514 3 3d DPYSL3 M362 362 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive L:1 0.0068 1 1 luad:1 ENST00000398514 3 3d DPYSL3 V410 410 100 4cns_A(0.008);4cns_B(0.0087);4cns_C(0.0081);4cns_D(0.0068) Cluster-exclusive I:1 0.0068 1 1 stad:1 ENST00000398514 3 3d PTBP2 K209 209 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive E:1 0.0073 1 1 ucec:1 ENST00000426398 2 3d PTBP2 I211 211 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive N:1 0.0073 1 1 coadread:1 ENST00000426398 2 3d PTBP2 L223 223 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive V:1 0.0073 1 1 coadread:1 ENST00000426398 2 3d PTBP2 Q224 224 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive L:1 0.0073 1 1 lusm:1 ENST00000426398 2 3d PTBP2 N261 261 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive S:1 0.0073 1 1 lusc:1 ENST00000426398 2 3d PTBP2 V262 262 102 3zzy_B(0.0073);3zzz_A(0.0078) Cluster-exclusive L:1 0.0073 1 1 paad:1 ENST00000426398 2 3d CLTC R892 892 103 3iyv_A(0.0076);1xi5_A(0.0073);1xi4_A(0.0075) Cluster-exclusive I:1|K:1 0.0073 2 2 ucec:1|cscc:1 ENST00000269122 3 3d CLTC L894 894 103 3iyv_A(0.0076);1xi5_A(0.0073);1xi4_A(0.0075) Cluster-exclusive V:1|I:1 0.0073 2 2 coadread:1|blca:1 ENST00000269122 3 3d CLTC R895 895 103 3iyv_A(0.0076);1xi5_A(0.0073);1xi4_A(0.0075) Cluster-exclusive C:1 0.0073 1 1 coadread:1 ENST00000269122 3 3d NOTCH1 E455 455 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive K:5 0.0074 5 3 hnsc:3|cscc:1|luad:1 ENST00000277541 6 3d NOTCH1 C456 456 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive Y:2 0.0074 2 2 hnsc:1|lgg:1 ENST00000277541 6 3d NOTCH1 P460 460 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive S:1|L:3 0.0074 4 3 esca:1|skcm:1|cscc:2 ENST00000277541 6 3d NOTCH1 C461 461 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive Y:1 0.0074 1 1 hnsc:1 ENST00000277541 6 3d NOTCH1 A465 465 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive T:4 0.0074 4 4 coadread:1|esca:1|hnsc:1|lgg:1 ENST00000277541 6 3d NOTCH1 C467 467 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive F:1|Y:1 0.0074 2 2 cesc:1|lgg:1 ENST00000277541 6 3d NOTCH1 L468 468 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive R:1 0.0074 1 1 hnsc:1 ENST00000277541 6 3d NOTCH1 D469 469 106 4d0e_A(0.0078);4cue_A(0.0084);4cud_A(0.0094);4cuf_A(0.0082);4d0f_A(0.0074);2vj3_A(0.0078) Cluster-exclusive Y:2 0.0074 2 2 acc:1|paad:1 ENST00000277541 6 3d TP53 Y163 163 107 2mej_B(0.0075) Hotspot C:27|D:2|H:4|N:4 0.0075 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 M243 243 107 2mej_B(0.0075) Hotspot-linked I:1 0.0075 1 1 ucs:1 ENST00000269305 4 3d TP53 N247 247 107 2mej_B(0.0075) Hotspot-linked I:4 0.0075 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d PPP2R1A L173 173 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked M:1 0.0075 1 1 ucec:1 ENST00000322088 6 3d CD300C P34 34 110 2q87_A(0.0076) Cluster-exclusive T:1 0.0076 1 1 lihc:1 ENST00000330793 1 3d CD300C V35 35 110 2q87_A(0.0076) Cluster-exclusive L:2 0.0076 2 2 lihc:1|luad:1 ENST00000330793 1 3d CD300C L97 97 110 2q87_A(0.0076) Cluster-exclusive Q:1 0.0076 1 1 luad:1 ENST00000330793 1 3d CD300C E98 98 110 2q87_A(0.0076) Cluster-exclusive D:1 0.0076 1 1 ucec:1 ENST00000330793 1 3d CD300C L100 100 110 2q87_A(0.0076) Cluster-exclusive P:1 0.0076 1 1 brca:1 ENST00000330793 1 3d CD300C E102 102 110 2q87_A(0.0076) Cluster-exclusive D:2 0.0076 2 2 ucec:1|luad:1 ENST00000330793 1 3d CD300C D104 104 110 2q87_A(0.0076) Cluster-exclusive E:2 0.0076 2 1 luad:2 ENST00000330793 1 3d CD300C S130 130 110 2q87_A(0.0076) Cluster-exclusive F:1 0.0076 1 1 cscc:1 ENST00000330793 1 3d TMPRSS11E S246 246 111 2oq5_A(0.0076) Cluster-exclusive F:1 0.0076 1 1 cscc:1 ENST00000305363 4 3d TMPRSS11E F247 247 111 2oq5_A(0.0076) Cluster-exclusive Y:1 0.0076 1 1 acc:1 ENST00000305363 4 3d TMPRSS11E T250 250 111 2oq5_A(0.0076) Cluster-exclusive I:1|K:1 0.0076 2 2 lgg:1|luad:1 ENST00000305363 4 3d TMPRSS11E I251 251 111 2oq5_A(0.0076) Cluster-exclusive T:1 0.0076 1 1 lihc:1 ENST00000305363 4 3d TMPRSS11E P253 253 111 2oq5_A(0.0076) Cluster-exclusive H:1 0.0076 1 1 lusc:1 ENST00000305363 4 3d TMPRSS11E S254 254 111 2oq5_A(0.0076) Cluster-exclusive P:1|L:2 0.0076 3 3 acc:1|coadread:1|ucec:1 ENST00000305363 4 3d TMPRSS11E M256 256 111 2oq5_A(0.0076) Cluster-exclusive I:2 0.0076 2 1 skcm:2 ENST00000305363 4 3d TMPRSS11E R258 258 112 2oq5_A(0.0076) Cluster-exclusive L:1 0.0076 1 1 skcm:1 ENST00000305363 4 3d TMPRSS11E V293 293 112 2oq5_A(0.0076) Cluster-exclusive I:1 0.0076 1 1 luad:1 ENST00000305363 4 3d TMPRSS11E H328 328 113 2oq5_A(0.0076) Cluster-exclusive Y:1 0.0076 1 1 skcm:1 ENST00000305363 4 3d TMPRSS11E L329 329 113 2oq5_A(0.0076) Cluster-exclusive F:1 0.0076 1 1 hnsc:1 ENST00000305363 4 3d C3 P1007 1007 114 1w2s_A(0.0076) Cluster-exclusive F:1|L:1 0.0076 2 2 skcm:1|cscc:1 ENST00000245907 6 3d C3 S1008 1008 114 1w2s_A(0.0076) Cluster-exclusive L:2 0.0076 2 2 hnsc:1|ucec:1 ENST00000245907 6 3d C3 G1017 1017 114 1w2s_A(0.0076) Cluster-exclusive D:2 0.0076 2 2 skcm:1|luad:1 ENST00000245907 6 3d HSD17B10 G10 10 115 2o23_A(0.09);1so8_A(0.0861);1u7t_A(0.0772);1u7t_B(0.0756);1u7t_C(0.0741);1u7t_D(0.0765);1e6w_A(0.0094);1e3s_A(0.008);1e3w_D(0.0076);1e3w_C(0.0098);1e6w_D(0.0078);1e6w_C(0.009);1e3w_B(0.0084);1e3w_A(0.0101);1e6w_B(0.0116) Cluster-exclusive D:1 0.0076 1 1 skcm:1 ENST00000168216 6 3d HSD17B10 L11 11 115 2o23_A(0.09);1so8_A(0.0861);1u7t_A(0.0772);1u7t_B(0.0756);1u7t_C(0.0741);1u7t_D(0.0765);1e6w_A(0.0094);1e3s_A(0.008);1e3w_D(0.0076);1e3w_C(0.0098);1e6w_D(0.0078);1e6w_C(0.009);1e3w_B(0.0084);1e3w_A(0.0101);1e6w_B(0.0116) Cluster-exclusive M:1 0.0076 1 1 luad:1 ENST00000168216 6 3d HSD17B10 V12 12 115 2o23_A(0.09);1so8_A(0.0861);1u7t_A(0.0772);1u7t_B(0.0756);1u7t_C(0.0741);1u7t_D(0.0765);1e6w_A(0.0094);1e3s_A(0.008);1e3w_D(0.0076);1e3w_C(0.0098);1e6w_D(0.0078);1e6w_C(0.009);1e3w_B(0.0084);1e3w_A(0.0101);1e6w_B(0.0116) Cluster-exclusive A:1 0.0076 1 1 coadread:1 ENST00000168216 6 3d HSD17B10 A13 13 115 2o23_A(0.09);1so8_A(0.0861);1u7t_A(0.0772);1u7t_B(0.0756);1u7t_C(0.0741);1u7t_D(0.0765);1e6w_A(0.0094);1e3s_A(0.008);1e3w_D(0.0076);1e3w_C(0.0098);1e6w_D(0.0078);1e6w_C(0.009);1e3w_B(0.0084);1e3w_A(0.0101);1e6w_B(0.0116) Cluster-exclusive T:1 0.0076 1 1 ucec:1 ENST00000168216 6 3d HSD17B10 G34 34 115 2o23_A(0.09);1so8_A(0.0861);1u7t_A(0.0772);1u7t_B(0.0756);1u7t_C(0.0741);1u7t_D(0.0765);1e6w_A(0.0094);1e3s_A(0.008);1e3w_D(0.0076);1e3w_C(0.0098);1e6w_D(0.0078);1e6w_C(0.009);1e3w_B(0.0084);1e3w_A(0.0101);1e6w_B(0.0116) Cluster-exclusive E:1 0.0076 1 1 brca:1 ENST00000168216 6 3d TXNL4A D35 35 117 1pqn_A(0.0078) Cluster-exclusive N:1 0.0078 1 1 skcm:1 ENST00000269601 5 3d TXNL4A P36 36 117 1pqn_A(0.0078) Cluster-exclusive H:1 0.0078 1 1 lihc:1 ENST00000269601 5 3d TXNL4A K40 40 117 1pqn_A(0.0078) Cluster-exclusive N:1 0.0078 1 1 lgg:1 ENST00000269601 5 3d TXNL4A E43 43 117 1pqn_A(0.0078) Cluster-exclusive Q:1 0.0078 1 1 cesc:1 ENST00000269601 5 3d TXNL4A V44 44 117 1pqn_A(0.0078) Cluster-exclusive I:1 0.0078 1 1 skcm:1 ENST00000269601 5 3d TXNL4A A105 105 117 1pqn_A(0.0078) Cluster-exclusive V:1 0.0078 1 1 skcm:1 ENST00000269601 5 3d EP300 H1451 1451 119 3biy_A(0.0079) Hotspot P:1|R:1|L:1 0.0079 3 3 brca:1|blca:1|ucec:1 ENST00000263253 7 3d SLC25A5 R31 31 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive W:2 0.0079 2 1 coadread:2 ENST00000317881 8 3d SLC25A5 R72 72 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive H:1 0.0079 1 1 ucec:1 ENST00000317881 8 3d SLC25A5 G73 73 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive S:1 0.0079 1 1 kich:1 ENST00000317881 8 3d SLC25A5 N77 77 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive T:2 0.0079 2 2 lihc:1|cesc:1 ENST00000317881 8 3d SLC25A5 A137 137 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive V:1 0.0079 1 1 stad:1 ENST00000317881 8 3d SLC25A5 R138 138 120 1okc_A(0.0079);2c3e_A(0.008) Cluster-exclusive C:1|H:1 0.0079 2 2 stad:1|lihc:1 ENST00000317881 8 3d WDR75 I520 520 121 2qnk_A(0.0079) Cluster-exclusive T:1 0.0079 1 1 brca:1 ENST00000314761 4 3d WDR75 V521 521 121 2qnk_A(0.0079) Cluster-exclusive I:1 0.0079 1 1 hnsc:1 ENST00000314761 4 3d WDR75 T522 522 121 2qnk_A(0.0079) Cluster-exclusive I:1 0.0079 1 1 ucec:1 ENST00000314761 4 3d WDR75 A539 539 121 2qnk_A(0.0079) Cluster-exclusive V:1 0.0079 1 1 lihc:1 ENST00000314761 4 3d WDR75 L565 565 121 2qnk_A(0.0079) Cluster-exclusive I:1 0.0079 1 1 ucec:1 ENST00000314761 4 3d WDR75 S592 592 121 2qnk_A(0.0079) Cluster-exclusive L:1 0.0079 1 1 skcm:1 ENST00000314761 4 3d PIK3R1 I559 559 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot-linked T:1|V:1 0.0081 2 2 brca:1|cesc:1 ENST00000274335 5 3d PIK3R1 D560 560 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot-linked G:2|H:2|N:1 0.0081 5 4 gbm:2|hnsc:1|lgg:1|luad:1 ENST00000274335 5 3d PIK3R1 N564 564 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot D:6 0.0081 6 4 coadread:2|skcm:1|ucec:1|lgg:2 ENST00000274335 5 3d PIK3R1 S565 565 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot-linked R:1|N:1 0.0081 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot E:5 0.0081 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 122 4ovu_B(0.0094);4l23_B(0.0081);4a55_B(0.0098) Hotspot-linked T:1 0.0081 1 1 ucec:1 ENST00000274335 5 3d PARD3 V48 48 123 2ns5_A(0.0081) Cluster-exclusive A:1|G:1 0.0081 2 2 brca:1|ucec:1 ENST00000374789 3 3d PARD3 R50 50 123 2ns5_A(0.0081) Cluster-exclusive G:1 0.0081 1 1 hnsc:1 ENST00000374789 3 3d PARD3 L51 51 123 2ns5_A(0.0081) Cluster-exclusive W:1 0.0081 1 1 thca:1 ENST00000374789 3 3d PARD3 I58 58 123 2ns5_A(0.0081) Cluster-exclusive M:1 0.0081 1 1 dlbc:1 ENST00000374789 3 3d PARD3 D60 60 123 2ns5_A(0.0081) Cluster-exclusive N:2 0.0081 2 2 paad:1|skcm:1 ENST00000374789 3 3d SERPINB3 N8 8 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive K:1 0.0081 1 1 luad:1 ENST00000283752 5 3d SERPINB3 T9 9 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive N:1 0.0081 1 1 luad:1 ENST00000283752 5 3d SERPINB3 K10 10 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive N:1 0.0081 1 1 luad:1 ENST00000283752 5 3d SERPINB3 F11 11 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive L:1 0.0081 1 1 coadread:1 ENST00000283752 5 3d SERPINB3 D14 14 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive H:1 0.0081 1 1 hnsc:1 ENST00000283752 5 3d SERPINB3 L15 15 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive M:1 0.0081 1 1 prad:1 ENST00000283752 5 3d SERPINB3 P31 31 124 2zv6_C(0.0081);2zv6_A(0.0099) Cluster-exclusive L:1 0.0081 1 1 luad:1 ENST00000283752 5 3d FGF9 G80 80 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive D:1 0.0082 1 1 stad:1 ENST00000382353 5 3d FGF9 T81 81 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive S:1 0.0082 1 1 hnsc:1 ENST00000382353 5 3d FGF9 I82 82 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive V:1 0.0082 1 1 luad:1 ENST00000382353 5 3d FGF9 G117 117 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive W:1 0.0082 1 1 skcm:1 ENST00000382353 5 3d FGF9 L124 124 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive M:1 0.0082 1 1 skcm:1 ENST00000382353 5 3d FGF9 G126 126 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive R:1 0.0082 1 1 cscc:1 ENST00000382353 5 3d FGF9 S127 127 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive T:1 0.0082 1 1 prad:1 ENST00000382353 5 3d FGF9 E128 128 125 1g82_A(0.0082);1g82_D(0.0135);1g82_C(0.0104) Cluster-exclusive K:1 0.0082 1 1 skcm:1 ENST00000382353 5 3d SLIT2 A455 455 126 3ee6_A(0.0083) Cluster-exclusive D:1|V:1 0.0083 2 2 coadread:1|hnsc:1 ENST00000504154 1 3d SLIT2 R456 456 126 3ee6_A(0.0083) Cluster-exclusive C:1|H:1 0.0083 2 2 stad:1|mcl:1 ENST00000504154 1 3d SLIT2 S459 459 126 3ee6_A(0.0083) Cluster-exclusive 0.0083 1 ENST00000504154 1 3d SLIT2 P460 460 126 3ee6_A(0.0083) Cluster-exclusive S:1 0.0083 1 1 skcm:1 ENST00000504154 1 3d SLIT2 R461 461 126 3ee6_A(0.0083) Cluster-exclusive C:2 0.0083 2 2 paad:1|prad:1 ENST00000504154 1 3d SLIT2 R462 462 126 3ee6_A(0.0083) Cluster-exclusive C:3 0.0083 3 3 acc:1|cll:1|lihc:1 ENST00000504154 1 3d SLIT2 N465 465 126 3ee6_A(0.0083) Cluster-exclusive S:1 0.0083 1 1 luad:1 ENST00000504154 1 3d SLIT2 R467 467 126 3ee6_A(0.0083) Cluster-exclusive G:1|I:2|K:1 0.0083 4 4 ucs:1|skcm:1|ucec:1|luad:1 ENST00000504154 1 3d SLIT2 A505 505 126 3ee6_A(0.0083) Cluster-exclusive V:1 0.0083 1 1 skcm:1 ENST00000504154 1 3d SLIT2 A536 536 126 3ee6_A(0.0083) Cluster-exclusive V:1 0.0083 1 1 cscc:1 ENST00000504154 1 3d CLTC N1288 1288 127 1b89_A(0.0084) Cluster-exclusive K:1 0.0084 1 1 lusc:1 ENST00000269122 3 3d CLTC Y1289 1289 127 1b89_A(0.0084) Cluster-exclusive C:1 0.0084 1 1 ov:1 ENST00000269122 3 3d CLTC Y1290 1290 127 1b89_A(0.0084) Cluster-exclusive D:1 0.0084 1 1 hnsc:1 ENST00000269122 3 3d CLTC R1293 1293 127 1b89_A(0.0084) Cluster-exclusive C:1 0.0084 1 1 esca:1 ENST00000269122 3 3d CLTC G1294 1294 127 1b89_A(0.0084) Cluster-exclusive V:1 0.0084 1 1 ucec:1 ENST00000269122 3 3d CLTC L1299 1299 127 1b89_A(0.0084) Cluster-exclusive P:1 0.0084 1 1 ucec:1 ENST00000269122 3 3d RAC1 G15 15 128 1foe_B(0.0714);1he1_C(0.0762);4gzl_A(0.0768);4gzl_B(0.0733);1he1_D(0.0766);3su8_A(0.0687);2ov2_B(0.0637);2ov2_D(0.0664);1foe_H(0.0727);2ov2_E(0.0621);1foe_F(0.0722);1foe_D(0.0731);2ov2_A(0.0629);1i4t_D(0.0655);2p2l_C(0.0681);2ic5_B(0.067);1ds6_A(0.0671);1i4l_D(0.0731);2ic5_A(0.0623);2p2l_A(0.069);2p2l_B(0.0699);2h7v_A(0.0646);1i4d_D(0.0751);1e96_A(0.0708);3ryt_C(0.0686);2w2v_D(0.0581);2w2x_B(0.0637);2w2v_C(0.0087);2w2x_A(0.0678);2w2v_B(0.0567);2w2v_A(0.0577);2wkq_A(0.0661);2h7v_B(0.069);2w2t_A(0.0611);1g4u_R(0.0537);4gzm_A(0.0739);4gzm_B(0.0714);2vrw_A(0.0686);2fju_A(0.0774);2g0n_A(0.0632);1hh4_B(0.0551);1hh4_A(0.0568);3sua_C(0.0762);2g0n_B(0.0637);2qme_A(0.0699);2ov2_H(0.0672);3th5_B(0.074);3th5_A(0.0783);1mh1_A(0.0685);1ryf_A(0.0578);1ryf_B(0.0643);1ryh_A(0.0642);1ryh_B(0.0606);2c2h_A(0.0099);2c2h_B(0.0615);3sua_A(0.0721);2wkp_A(0.0703);3sua_B(0.0816);2wkr_A(0.0689) Hotspot-linked S:1 0.0087 1 1 hnsc:1 ENST00000356142 4 3d RAC1 C18 18 128 1foe_B(0.0714);1he1_C(0.0762);4gzl_A(0.0768);4gzl_B(0.0733);1he1_D(0.0766);3su8_A(0.0687);2ov2_B(0.0637);2ov2_D(0.0664);1foe_H(0.0727);2ov2_E(0.0621);1foe_F(0.0722);1foe_D(0.0731);2ov2_A(0.0629);1i4t_D(0.0655);2p2l_C(0.0681);2ic5_B(0.067);1ds6_A(0.0671);1i4l_D(0.0731);2ic5_A(0.0623);2p2l_A(0.069);2p2l_B(0.0699);2h7v_A(0.0646);1i4d_D(0.0751);1e96_A(0.0708);3ryt_C(0.0686);2w2v_D(0.0581);2w2x_B(0.0637);2w2v_C(0.0087);2w2x_A(0.0678);2w2v_B(0.0567);2w2v_A(0.0577);2wkq_A(0.0661);2h7v_B(0.069);2w2t_A(0.0611);1g4u_R(0.0537);4gzm_A(0.0739);4gzm_B(0.0714);2vrw_A(0.0686);2fju_A(0.0774);2g0n_A(0.0632);1hh4_B(0.0551);1hh4_A(0.0568);3sua_C(0.0762);2g0n_B(0.0637);2qme_A(0.0699);2ov2_H(0.0672);3th5_B(0.074);3th5_A(0.0783);1mh1_A(0.0685);1ryf_A(0.0578);1ryf_B(0.0643);1ryh_A(0.0642);1ryh_B(0.0606);2c2h_A(0.0099);2c2h_B(0.0615);3sua_A(0.0721);2wkp_A(0.0703);3sua_B(0.0816);2wkr_A(0.0689) Hotspot-linked F:1|Y:1 0.0087 2 1 hnsc:2 ENST00000356142 4 3d RAC1 P29 29 128 1foe_B(0.0714);1he1_C(0.0762);4gzl_A(0.0768);4gzl_B(0.0733);1he1_D(0.0766);3su8_A(0.0687);2ov2_B(0.0637);2ov2_D(0.0664);1foe_H(0.0727);2ov2_E(0.0621);1foe_F(0.0722);1foe_D(0.0731);2ov2_A(0.0629);1i4t_D(0.0655);2p2l_C(0.0681);2ic5_B(0.067);1ds6_A(0.0671);1i4l_D(0.0731);2ic5_A(0.0623);2p2l_A(0.069);2p2l_B(0.0699);2h7v_A(0.0646);1i4d_D(0.0751);1e96_A(0.0708);3ryt_C(0.0686);2w2v_D(0.0581);2w2x_B(0.0637);2w2v_C(0.0087);2w2x_A(0.0678);2w2v_B(0.0567);2w2v_A(0.0577);2wkq_A(0.0661);2h7v_B(0.069);2w2t_A(0.0611);1g4u_R(0.0537);4gzm_A(0.0739);4gzm_B(0.0714);2vrw_A(0.0686);2fju_A(0.0774);2g0n_A(0.0632);1hh4_B(0.0551);1hh4_A(0.0568);3sua_C(0.0762);2g0n_B(0.0637);2qme_A(0.0699);2ov2_H(0.0672);3th5_B(0.074);3th5_A(0.0783);1mh1_A(0.0685);1ryf_A(0.0578);1ryf_B(0.0643);1ryh_A(0.0642);1ryh_B(0.0606);2c2h_A(0.0099);2c2h_B(0.0615);3sua_A(0.0721);2wkp_A(0.0703);3sua_B(0.0816);2wkr_A(0.0689) Hotspot S:23|T:1|L:5 0.0087 29 4 hnsc:3|skcm:24|ucec:1|cscc:1 ENST00000356142 4 3d RAC1 A159 159 128 1foe_B(0.0714);1he1_C(0.0762);4gzl_A(0.0768);4gzl_B(0.0733);1he1_D(0.0766);3su8_A(0.0687);2ov2_B(0.0637);2ov2_D(0.0664);1foe_H(0.0727);2ov2_E(0.0621);1foe_F(0.0722);1foe_D(0.0731);2ov2_A(0.0629);1i4t_D(0.0655);2p2l_C(0.0681);2ic5_B(0.067);1ds6_A(0.0671);1i4l_D(0.0731);2ic5_A(0.0623);2p2l_A(0.069);2p2l_B(0.0699);2h7v_A(0.0646);1i4d_D(0.0751);1e96_A(0.0708);3ryt_C(0.0686);2w2v_D(0.0581);2w2x_B(0.0637);2w2v_C(0.0087);2w2x_A(0.0678);2w2v_B(0.0567);2w2v_A(0.0577);2wkq_A(0.0661);2h7v_B(0.069);2w2t_A(0.0611);1g4u_R(0.0537);4gzm_A(0.0739);4gzm_B(0.0714);2vrw_A(0.0686);2fju_A(0.0774);2g0n_A(0.0632);1hh4_B(0.0551);1hh4_A(0.0568);3sua_C(0.0762);2g0n_B(0.0637);2qme_A(0.0699);2ov2_H(0.0672);3th5_B(0.074);3th5_A(0.0783);1mh1_A(0.0685);1ryf_A(0.0578);1ryf_B(0.0643);1ryh_A(0.0642);1ryh_B(0.0606);2c2h_A(0.0099);2c2h_B(0.0615);3sua_A(0.0721);2wkp_A(0.0703);3sua_B(0.0816);2wkr_A(0.0689) Hotspot-linked V:10 0.0087 10 5 coadread:1|hnsc:6|hgg:1|cesc:1|luad:1 ENST00000356142 4 3d KDR A1031 1031 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive T:1 0.0089 1 1 coadread:1 ENST00000263923 4 3d KDR R1032 1032 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive Q:5 0.0089 5 2 coadread:1|skcm:4 ENST00000263923 4 3d KDR V1093 1093 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive I:1 0.0089 1 1 gbm:1 ENST00000263923 4 3d KDR W1096 1096 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive R:1 0.0089 1 1 luad:1 ENST00000263923 4 3d KDR E1097 1097 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive K:1 0.0089 1 1 hnsc:1 ENST00000263923 4 3d KDR F1099 1099 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive V:1 0.0089 1 1 esca:1 ENST00000263923 4 3d KDR S1100 1100 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive F:5 0.0089 5 1 skcm:5 ENST00000263923 4 3d KDR A1103 1103 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive D:1 0.0089 1 1 esca:1 ENST00000263923 4 3d KDR P1105 1105 130 1vr2_A(0.009);1ywn_A(0.0089) Cluster-exclusive L:1 0.0089 1 1 cscc:1 ENST00000263923 4 3d CHN2 R39 39 131 1xa6_A(0.009) Cluster-exclusive C:1|S:1|H:1 0.009 3 2 gbm:1|lihc:2 ENST00000222792 6 3d CHN2 P40 40 131 1xa6_A(0.009) Cluster-exclusive R:1|L:1 0.009 2 2 lihc:1|kirc:1 ENST00000222792 6 3d CHN2 K41 41 131 1xa6_A(0.009) Cluster-exclusive N:1 0.009 1 1 luad:1 ENST00000222792 6 3d CHN2 R42 42 131 1xa6_A(0.009) Cluster-exclusive G:1 0.009 1 1 gbm:1 ENST00000222792 6 3d CHN2 I43 43 131 1xa6_A(0.009) Cluster-exclusive M:2 0.009 2 1 lusc:2 ENST00000222792 6 3d CHN2 V76 76 131 1xa6_A(0.009) Cluster-exclusive M:1 0.009 1 1 esca:1 ENST00000222792 6 3d CHN2 A79 79 131 1xa6_A(0.009) Cluster-exclusive V:1 0.009 1 1 cesc:1 ENST00000222792 6 3d CACNA1E E1108 1108 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive D:1 0.009 1 1 coadread:1 ENST00000367573 2 3d CACNA1E E1109 1109 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive D:1 0.009 1 1 luad:1 ENST00000367573 2 3d CACNA1E E1110 1110 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive D:1 0.009 1 1 luad:1 ENST00000367573 2 3d CACNA1E E1112 1112 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive K:1 0.009 1 1 skcm:1 ENST00000367573 2 3d CACNA1E K1113 1113 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive N:1 0.009 1 1 ucec:1 ENST00000367573 2 3d CACNA1E Q1116 1116 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive K:1 0.009 1 1 lihc:1 ENST00000367573 2 3d CACNA1E K1117 1117 132 3eg9_A(0.0101);3egx_A(0.009);3egd_A(0.0115);2nut_A(0.0099);3efo_A(0.0103);2nup_A(0.0101) Cluster-exclusive N:1 0.009 1 1 coadread:1 ENST00000367573 2 3d H2AC8 A70 70 134 1hio_A(0.0093) Cluster-exclusive T:1 0.0093 1 1 blca:1 ENST00000303910 2 3d H2AC8 R72 72 134 1hio_A(0.0093) Cluster-exclusive S:1 0.0093 1 1 mbl:1 ENST00000303910 2 3d H2AC8 D73 73 134 1hio_A(0.0093) Cluster-exclusive N:1 0.0093 1 1 stad:1 ENST00000303910 2 3d H2AC8 N74 74 134 1hio_A(0.0093) Cluster-exclusive I:1 0.0093 1 1 luad:1 ENST00000303910 2 3d ITGA4 G53 53 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive V:1 0.0095 1 1 stad:1 ENST00000397033 2 3d ITGA4 L427 427 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive V:1 0.0095 1 1 skcm:1 ENST00000397033 2 3d ITGA4 S428 428 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive T:1 0.0095 1 1 luad:1 ENST00000397033 2 3d ITGA4 G431 431 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive E:1|V:1 0.0095 2 2 blca:1|hnsc:1 ENST00000397033 2 3d ITGA4 G451 451 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive R:1 0.0095 1 1 blca:1 ENST00000397033 2 3d ITGA4 A452 452 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive V:1 0.0095 1 1 coadread:1 ENST00000397033 2 3d ITGA4 R454 454 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive W:2|L:1 0.0095 3 2 skcm:2|kirp:1 ENST00000397033 2 3d ITGA4 S455 455 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive Y:1 0.0095 1 1 cesc:1 ENST00000397033 2 3d ITGA4 S457 457 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive P:1|F:1 0.0095 2 2 ucec:1|cesc:1 ENST00000397033 2 3d ITGA4 A458 458 135 3v4v_C(0.0124);3v4v_A(0.0139);3v4p_C(0.0104);3v4p_A(0.0095) Cluster-exclusive P:1 0.0095 1 1 luad:1 ENST00000397033 2 3d CAND1 F371 371 136 1u6g_C(0.0095) Cluster-exclusive I:1 0.0095 1 1 stad:1 ENST00000545606 1 3d CAND1 Y372 372 136 1u6g_C(0.0095) Cluster-exclusive C:1 0.0095 1 1 luad:1 ENST00000545606 1 3d CAND1 S376 376 136 1u6g_C(0.0095) Cluster-exclusive P:1 0.0095 1 1 coadread:1 ENST00000545606 1 3d CAND1 A397 397 136 1u6g_C(0.0095) Cluster-exclusive T:1 0.0095 1 1 gbm:1 ENST00000545606 1 3d CAND1 L399 399 136 1u6g_C(0.0095) Cluster-exclusive R:1 0.0095 1 1 thca:1 ENST00000545606 1 3d CAND1 L401 401 136 1u6g_C(0.0095) Cluster-exclusive I:1 0.0095 1 1 hnsc:1 ENST00000545606 1 3d CAND1 T405 405 136 1u6g_C(0.0095) Cluster-exclusive S:1 0.0095 1 1 luad:1 ENST00000545606 1 3d CAND1 R406 406 136 1u6g_C(0.0095) Cluster-exclusive H:1 0.0095 1 1 stad:1 ENST00000545606 1 3d ZNF98 H504 504 137 3brv_B(0.0098) Cluster-exclusive N:1 0.0098 1 1 lusc:1 ENST00000357774 5 3d MDGA2 P447 447 139 3k71_B(0.0114);3k72_B(0.0101);3k6s_B(0.0098) Cluster-exclusive T:1 0.0098 1 1 lusc:1 ENST00000399232 2 3d MDGA2 E449 449 139 3k71_B(0.0114);3k72_B(0.0101);3k6s_B(0.0098) Cluster-exclusive K:1 0.0098 1 1 cscc:1 ENST00000399232 2 3d MDGA2 S451 451 139 3k71_B(0.0114);3k72_B(0.0101);3k6s_B(0.0098) Cluster-exclusive L:1 0.0098 1 1 skcm:1 ENST00000399232 2 3d MDGA2 G458 458 139 3k71_B(0.0114);3k72_B(0.0101);3k6s_B(0.0098) Cluster-exclusive E:1 0.0098 1 1 skcm:1 ENST00000399232 2 3d MDGA2 T460 460 139 3k71_B(0.0114);3k72_B(0.0101);3k6s_B(0.0098) Cluster-exclusive A:1 0.0098 1 1 lusc:1 ENST00000399232 2 3d TUBA3D V181 181 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive M:2 0.0103 2 2 paad:1|luad:1 ENST00000321253 6 3d TUBA3D V182 182 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive M:1 0.0103 1 1 hnsc:1 ENST00000321253 6 3d TUBA3D H393 393 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive D:1 0.0103 1 1 luad:1 ENST00000321253 6 3d TUBA3D D396 396 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive N:2 0.0103 2 2 coadread:1|skcm:1 ENST00000321253 6 3d TUBA3D M398 398 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive V:1 0.0103 1 1 stad:1 ENST00000321253 6 3d TUBA3D Y399 399 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive S:1 0.0103 1 1 luad:1 ENST00000321253 6 3d TUBA3D R402 402 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive Q:1 0.0103 1 1 luad:1 ENST00000321253 6 3d TUBA3D A403 403 141 3edl_F(0.0117);4i4t_C(0.0383);4i55_C(0.0368);4i50_C(0.0383);3du7_C(0.0138);4i4t_A(0.0302);4i55_A(0.0383);1sa0_C(0.0115);3du7_A(0.012);4iij_A(0.0392);4ihj_A(0.0393);1sa0_A(0.0103);4iij_C(0.0388);4i50_A(0.0422);4ihj_C(0.0388);1z2b_C(0.0151);1z2b_A(0.014);3e22_A(0.0117) Cluster-exclusive S:1 0.0103 1 1 npc:1 ENST00000321253 6 3d IGFBP3 S140 140 142 1rx0_A(0.0111);1rx0_C(0.0103) Cluster-exclusive L:1 0.0103 1 1 coadread:1 ENST00000275521 6 3d IGFBP3 R144 144 142 1rx0_A(0.0111);1rx0_C(0.0103) Cluster-exclusive C:1|H:1 0.0103 2 2 coadread:1|ucec:1 ENST00000275521 6 3d IGFBP3 A146 146 142 1rx0_A(0.0111);1rx0_C(0.0103) Cluster-exclusive T:1 0.0103 1 1 ucec:1 ENST00000275521 6 3d IGFBP3 G147 147 142 1rx0_A(0.0111);1rx0_C(0.0103) Cluster-exclusive S:1 0.0103 1 1 stad:1 ENST00000275521 6 3d SMAD4 L57 57 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive V:1 0.0105 1 1 coadread:1 ENST00000342988 3 3d SMAD4 Y95 95 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive C:1 0.0105 1 1 luad:1 ENST00000342988 3 3d SMAD4 A96 96 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive D:1 0.0105 1 1 paad:1 ENST00000342988 3 3d SMAD4 W99 99 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive C:1 0.0105 1 1 hnsc:1 ENST00000342988 3 3d SMAD4 R100 100 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive W:1 0.0105 1 1 luad:1 ENST00000342988 3 3d CUL5 V185 185 144 4n9f_V(0.0105) Cluster-exclusive I:1 0.0105 1 1 lusc:1 ENST00000393094 2 3d CUL5 N186 186 144 4n9f_V(0.0105) Cluster-exclusive K:1 0.0105 1 1 skcm:1 ENST00000393094 2 3d CUL5 L187 187 144 4n9f_V(0.0105) Cluster-exclusive R:1 0.0105 1 1 nbl:1 ENST00000393094 2 3d CUL5 C188 188 144 4n9f_V(0.0105) Cluster-exclusive F:1 0.0105 1 1 ov:1 ENST00000393094 2 3d CUL5 P191 191 144 4n9f_V(0.0105) Cluster-exclusive S:1 0.0105 1 1 skcm:1 ENST00000393094 2 3d CUL5 E192 192 144 4n9f_V(0.0105) Cluster-exclusive K:1 0.0105 1 1 blca:1 ENST00000393094 2 3d CUL5 K194 194 144 4n9f_V(0.0105) Cluster-exclusive T:1 0.0105 1 1 gbm:1 ENST00000393094 2 3d SIRT3 F192 192 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive L:1 0.0105 1 1 hnsc:1 ENST00000382743 4 3d SIRT3 T255 255 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive A:1 0.0105 1 1 lihc:1 ENST00000382743 4 3d SIRT3 V286 286 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive I:1 0.0105 1 1 ucec:1 ENST00000382743 4 3d SIRT3 V287 287 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive L:1 0.0105 1 1 luad:1 ENST00000382743 4 3d SIRT3 K288 288 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive E:1 0.0105 1 1 luad:1 ENST00000382743 4 3d SIRT3 I291 291 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive S:1 0.0105 1 1 coadread:1 ENST00000382743 4 3d SIRT3 V292 292 145 4v1c_E(0.0118);4fz3_A(0.0133);4bn5_G(0.0105) Cluster-exclusive L:1 0.0105 1 1 brca:1 ENST00000382743 4 3d BRAF L514 514 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot-linked P:1 0.0106 1 1 luad:1 ENST00000288602 6 3d BRAF H574 574 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot-linked Q:1|N:1 0.0106 2 1 luad:2 ENST00000288602 6 3d ANKLE2 W495 495 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive C:1 0.011 1 1 luad:1 ENST00000357997 5 3d ANKLE2 E533 533 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive K:1 0.011 1 1 lusc:1 ENST00000357997 5 3d ANKLE2 D534 534 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive N:1 0.011 1 1 brca:1 ENST00000357997 5 3d ANKLE2 R536 536 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive C:2|H:1 0.011 3 2 coadread:2|ucec:1 ENST00000357997 5 3d ANKLE2 K537 537 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive R:1|T:1|N:1 0.011 3 3 brca:1|stad:1|lihc:1 ENST00000357997 5 3d ANKLE2 Q614 614 148 3bxw_A(0.0126);3bxw_B(0.011) Cluster-exclusive E:1 0.011 1 1 luad:1 ENST00000357997 5 3d IFIT1 S13 13 149 4hou_B(0.0112);4hou_A(0.0169) Cluster-exclusive R:1 0.0112 1 1 kirc:1 ENST00000371804 3 3d IFIT1 V121 121 149 4hou_B(0.0112);4hou_A(0.0169) Cluster-exclusive G:1 0.0112 1 1 brca:1 ENST00000371804 3 3d IFIT1 P131 131 149 4hou_B(0.0112);4hou_A(0.0169) Cluster-exclusive S:1 0.0112 1 1 ucec:1 ENST00000371804 3 3d IFIT1 R133 133 149 4hou_B(0.0112);4hou_A(0.0169) Cluster-exclusive C:1|H:2 0.0112 3 3 mmyl:1|coadread:1|ucs:1 ENST00000371804 3 3d IFIT1 R135 135 149 4hou_B(0.0112);4hou_A(0.0169) Cluster-exclusive I:1|K:1 0.0112 2 2 coadread:1|skcm:1 ENST00000371804 3 3d RBP2 E18 18 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive D:1|G:1 0.0112 2 2 gbm:1|kirp:1 ENST00000232217 2 3d RBP2 M21 21 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive K:1|L:1 0.0112 2 1 stad:2 ENST00000232217 2 3d RBP2 A23 23 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive S:1|T:1 0.0112 2 2 paad:1|lusc:1 ENST00000232217 2 3d RBP2 I26 26 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive T:1 0.0112 1 1 blca:1 ENST00000232217 2 3d RBP2 D27 27 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive N:1 0.0112 1 1 luad:1 ENST00000232217 2 3d RBP2 F28 28 150 1b4m_A(0.0112);1eii_A(0.0154) Cluster-exclusive S:1 0.0112 1 1 ucec:1 ENST00000232217 2 3d GABPA A41 41 152 2juo_A(0.0114) Cluster-exclusive G:1 0.0114 1 1 lusc:1 ENST00000354828 3 3d GABPA I42 42 152 2juo_A(0.0114) Cluster-exclusive M:1 0.0114 1 1 lihc:1 ENST00000354828 3 3d GABPA G49 49 152 2juo_A(0.0114) Cluster-exclusive R:1 0.0114 1 1 lusc:1 ENST00000354828 3 3d GABPA L54 54 152 2juo_A(0.0114) Cluster-exclusive V:1 0.0114 1 1 ucec:1 ENST00000354828 3 3d GABPA L81 81 152 2juo_A(0.0114) Cluster-exclusive S:1 0.0114 1 1 ov:1 ENST00000354828 3 3d GABPA G90 90 152 2juo_A(0.0114) Cluster-exclusive E:1 0.0114 1 1 paad:1 ENST00000354828 3 3d GABPA T91 91 152 2juo_A(0.0114) Cluster-exclusive S:1|N:1 0.0114 2 2 skcm:1|luad:1 ENST00000354828 3 3d H2AJ R89 89 153 3b6g_C(0.0233);3b6g_G(0.0201);3azn_C(0.0453);3azj_G(0.0245);1tzy_E(0.0127);3azj_C(0.0387);3azf_G(0.0355);4j8x_C(0.0265);1p34_G(0.0209);3tu4_C(0.039);1p34_C(0.0416);1p3l_C(0.0287);3o62_G(0.0202);1tzy_A(0.0316);3azn_G(0.0341);3o62_C(0.0218);3kuy_C(0.0261);1p3m_G(0.0306);3w99_G(0.0298);1kx5_C(0.0498);3mnn_C(0.0262);2fj7_C(0.0213);3lz1_C(0.0283);3w99_C(0.0271);3lz1_G(0.0266);2fj7_G(0.023);3aze_C(0.049);3mgp_C(0.0261);3rej_G(0.0286);3a6n_C(0.0311);1m18_C(0.0238);3rej_C(0.0267);3a6n_G(0.0344);3mgp_G(0.0261);3uta_C(0.0257);1m18_G(0.0229);3b6f_G(0.0117);3b6f_C(0.0198);1aoi_C(0.0503);3av2_G(0.0294);4ld9_G(0.0114);4ld9_C(0.0129);1p3a_C(0.0236);3azm_C(0.0263);3azi_G(0.0261);1p3a_G(0.028);4j8w_C(0.0236);3azi_C(0.0504);3aze_G(0.0305);1p3i_C(0.0132);3av2_C(0.0244);1aoi_G(0.0393);1p3i_G(0.0273);1p3m_C(0.0235);3azm_G(0.0325);1zla_G(0.0218);3ayw_G(0.0334);3lz0_C(0.0279);1kx4_C(0.031);1zla_C(0.0186);3w98_G(0.0284);1kx4_G(0.0257);3ayw_C(0.043);3lz0_G(0.0256);3w98_C(0.0239);2pyo_G(0.0136);2aro_E(0.0122);2pyo_C(0.0163);3rek_G(0.0279);1hq3_A(0.0294);2aro_A(0.0315);3lja_G(0.0237);2nzd_C(0.0261);3rek_C(0.0301);1hq3_E(0.0156);3mgs_G(0.0236);3mgs_C(0.0279);3lja_C(0.0299);2nqb_G(0.0208);2cv5_G(0.0319);2nqb_C(0.0177);3av1_G(0.0273);2cv5_C(0.0487);1p3b_C(0.0212);3azl_C(0.0436);3azh_G(0.0299);4j8v_C(0.0217);3kwq_C(0.0237);1p3b_G(0.0253);1p3f_C(0.029);3azh_C(0.0316);3kwq_G(0.0278);3av1_C(0.0315);1p3f_G(0.0216);1eqz_A(0.0695);3azl_G(0.0282);1kx3_C(0.0278);1p3o_G(0.0236);3w97_G(0.0323);1kx3_G(0.0301);3azg_C(0.0481);3w97_C(0.0233);3c9k_A(0.0229);3mvd_C(0.0441);3rel_G(0.0231);3c1c_C(0.0282);3rel_C(0.0283);3c1c_G(0.0271);3mgr_G(0.0242);3reh_C(0.0228);3mgr_C(0.0285);3afa_C(0.0521);1s32_G(0.0239);1m1a_G(0.0233);3ut9_G(0.029);1m1a_C(0.0275);3ut9_C(0.0281);1s32_C(0.047);3azk_G(0.0306);3azk_C(0.0454);3azg_G(0.0333);1p3g_C(0.0139);4j8u_C(0.0244);1p3g_G(0.0399);1p3k_C(0.0244);3afa_G(0.0311);1p3k_G(0.0247);1p3o_C(0.0236);3lel_G(0.0193);1p3p_C(0.0272);1p3l_G(0.0398);2hio_A(0.0209);1p3p_G(0.0418);3kxb_C(0.0252);3lel_M(0.0244);3w96_G(0.034);3azf_C(0.0476);3kxb_G(0.031);3w96_C(0.0425);3lel_C(0.0253);3utb_G(0.0247);3c1b_C(0.0243);1m19_G(0.0253);3rei_C(0.0209);3utb_C(0.0281);3mgq_G(0.0246);3c1b_G(0.0277);2f8n_K(0.0357);1m19_C(0.0241);3mgq_C(0.0302) Cluster-exclusive C:1 0.0114 1 1 cscc:1 ENST00000389078 3 3d H2AJ D91 91 153 3b6g_C(0.0233);3b6g_G(0.0201);3azn_C(0.0453);3azj_G(0.0245);1tzy_E(0.0127);3azj_C(0.0387);3azf_G(0.0355);4j8x_C(0.0265);1p34_G(0.0209);3tu4_C(0.039);1p34_C(0.0416);1p3l_C(0.0287);3o62_G(0.0202);1tzy_A(0.0316);3azn_G(0.0341);3o62_C(0.0218);3kuy_C(0.0261);1p3m_G(0.0306);3w99_G(0.0298);1kx5_C(0.0498);3mnn_C(0.0262);2fj7_C(0.0213);3lz1_C(0.0283);3w99_C(0.0271);3lz1_G(0.0266);2fj7_G(0.023);3aze_C(0.049);3mgp_C(0.0261);3rej_G(0.0286);3a6n_C(0.0311);1m18_C(0.0238);3rej_C(0.0267);3a6n_G(0.0344);3mgp_G(0.0261);3uta_C(0.0257);1m18_G(0.0229);3b6f_G(0.0117);3b6f_C(0.0198);1aoi_C(0.0503);3av2_G(0.0294);4ld9_G(0.0114);4ld9_C(0.0129);1p3a_C(0.0236);3azm_C(0.0263);3azi_G(0.0261);1p3a_G(0.028);4j8w_C(0.0236);3azi_C(0.0504);3aze_G(0.0305);1p3i_C(0.0132);3av2_C(0.0244);1aoi_G(0.0393);1p3i_G(0.0273);1p3m_C(0.0235);3azm_G(0.0325);1zla_G(0.0218);3ayw_G(0.0334);3lz0_C(0.0279);1kx4_C(0.031);1zla_C(0.0186);3w98_G(0.0284);1kx4_G(0.0257);3ayw_C(0.043);3lz0_G(0.0256);3w98_C(0.0239);2pyo_G(0.0136);2aro_E(0.0122);2pyo_C(0.0163);3rek_G(0.0279);1hq3_A(0.0294);2aro_A(0.0315);3lja_G(0.0237);2nzd_C(0.0261);3rek_C(0.0301);1hq3_E(0.0156);3mgs_G(0.0236);3mgs_C(0.0279);3lja_C(0.0299);2nqb_G(0.0208);2cv5_G(0.0319);2nqb_C(0.0177);3av1_G(0.0273);2cv5_C(0.0487);1p3b_C(0.0212);3azl_C(0.0436);3azh_G(0.0299);4j8v_C(0.0217);3kwq_C(0.0237);1p3b_G(0.0253);1p3f_C(0.029);3azh_C(0.0316);3kwq_G(0.0278);3av1_C(0.0315);1p3f_G(0.0216);1eqz_A(0.0695);3azl_G(0.0282);1kx3_C(0.0278);1p3o_G(0.0236);3w97_G(0.0323);1kx3_G(0.0301);3azg_C(0.0481);3w97_C(0.0233);3c9k_A(0.0229);3mvd_C(0.0441);3rel_G(0.0231);3c1c_C(0.0282);3rel_C(0.0283);3c1c_G(0.0271);3mgr_G(0.0242);3reh_C(0.0228);3mgr_C(0.0285);3afa_C(0.0521);1s32_G(0.0239);1m1a_G(0.0233);3ut9_G(0.029);1m1a_C(0.0275);3ut9_C(0.0281);1s32_C(0.047);3azk_G(0.0306);3azk_C(0.0454);3azg_G(0.0333);1p3g_C(0.0139);4j8u_C(0.0244);1p3g_G(0.0399);1p3k_C(0.0244);3afa_G(0.0311);1p3k_G(0.0247);1p3o_C(0.0236);3lel_G(0.0193);1p3p_C(0.0272);1p3l_G(0.0398);2hio_A(0.0209);1p3p_G(0.0418);3kxb_C(0.0252);3lel_M(0.0244);3w96_G(0.034);3azf_C(0.0476);3kxb_G(0.031);3w96_C(0.0425);3lel_C(0.0253);3utb_G(0.0247);3c1b_C(0.0243);1m19_G(0.0253);3rei_C(0.0209);3utb_C(0.0281);3mgq_G(0.0246);3c1b_G(0.0277);2f8n_K(0.0357);1m19_C(0.0241);3mgq_C(0.0302) Cluster-exclusive E:1 0.0114 1 1 mbl:1 ENST00000389078 3 3d H2AJ E93 93 153 3b6g_C(0.0233);3b6g_G(0.0201);3azn_C(0.0453);3azj_G(0.0245);1tzy_E(0.0127);3azj_C(0.0387);3azf_G(0.0355);4j8x_C(0.0265);1p34_G(0.0209);3tu4_C(0.039);1p34_C(0.0416);1p3l_C(0.0287);3o62_G(0.0202);1tzy_A(0.0316);3azn_G(0.0341);3o62_C(0.0218);3kuy_C(0.0261);1p3m_G(0.0306);3w99_G(0.0298);1kx5_C(0.0498);3mnn_C(0.0262);2fj7_C(0.0213);3lz1_C(0.0283);3w99_C(0.0271);3lz1_G(0.0266);2fj7_G(0.023);3aze_C(0.049);3mgp_C(0.0261);3rej_G(0.0286);3a6n_C(0.0311);1m18_C(0.0238);3rej_C(0.0267);3a6n_G(0.0344);3mgp_G(0.0261);3uta_C(0.0257);1m18_G(0.0229);3b6f_G(0.0117);3b6f_C(0.0198);1aoi_C(0.0503);3av2_G(0.0294);4ld9_G(0.0114);4ld9_C(0.0129);1p3a_C(0.0236);3azm_C(0.0263);3azi_G(0.0261);1p3a_G(0.028);4j8w_C(0.0236);3azi_C(0.0504);3aze_G(0.0305);1p3i_C(0.0132);3av2_C(0.0244);1aoi_G(0.0393);1p3i_G(0.0273);1p3m_C(0.0235);3azm_G(0.0325);1zla_G(0.0218);3ayw_G(0.0334);3lz0_C(0.0279);1kx4_C(0.031);1zla_C(0.0186);3w98_G(0.0284);1kx4_G(0.0257);3ayw_C(0.043);3lz0_G(0.0256);3w98_C(0.0239);2pyo_G(0.0136);2aro_E(0.0122);2pyo_C(0.0163);3rek_G(0.0279);1hq3_A(0.0294);2aro_A(0.0315);3lja_G(0.0237);2nzd_C(0.0261);3rek_C(0.0301);1hq3_E(0.0156);3mgs_G(0.0236);3mgs_C(0.0279);3lja_C(0.0299);2nqb_G(0.0208);2cv5_G(0.0319);2nqb_C(0.0177);3av1_G(0.0273);2cv5_C(0.0487);1p3b_C(0.0212);3azl_C(0.0436);3azh_G(0.0299);4j8v_C(0.0217);3kwq_C(0.0237);1p3b_G(0.0253);1p3f_C(0.029);3azh_C(0.0316);3kwq_G(0.0278);3av1_C(0.0315);1p3f_G(0.0216);1eqz_A(0.0695);3azl_G(0.0282);1kx3_C(0.0278);1p3o_G(0.0236);3w97_G(0.0323);1kx3_G(0.0301);3azg_C(0.0481);3w97_C(0.0233);3c9k_A(0.0229);3mvd_C(0.0441);3rel_G(0.0231);3c1c_C(0.0282);3rel_C(0.0283);3c1c_G(0.0271);3mgr_G(0.0242);3reh_C(0.0228);3mgr_C(0.0285);3afa_C(0.0521);1s32_G(0.0239);1m1a_G(0.0233);3ut9_G(0.029);1m1a_C(0.0275);3ut9_C(0.0281);1s32_C(0.047);3azk_G(0.0306);3azk_C(0.0454);3azg_G(0.0333);1p3g_C(0.0139);4j8u_C(0.0244);1p3g_G(0.0399);1p3k_C(0.0244);3afa_G(0.0311);1p3k_G(0.0247);1p3o_C(0.0236);3lel_G(0.0193);1p3p_C(0.0272);1p3l_G(0.0398);2hio_A(0.0209);1p3p_G(0.0418);3kxb_C(0.0252);3lel_M(0.0244);3w96_G(0.034);3azf_C(0.0476);3kxb_G(0.031);3w96_C(0.0425);3lel_C(0.0253);3utb_G(0.0247);3c1b_C(0.0243);1m19_G(0.0253);3rei_C(0.0209);3utb_C(0.0281);3mgq_G(0.0246);3c1b_G(0.0277);2f8n_K(0.0357);1m19_C(0.0241);3mgq_C(0.0302) Cluster-exclusive D:1 0.0114 1 1 ov:1 ENST00000389078 3 3d H2AJ N95 95 153 3b6g_C(0.0233);3b6g_G(0.0201);3azn_C(0.0453);3azj_G(0.0245);1tzy_E(0.0127);3azj_C(0.0387);3azf_G(0.0355);4j8x_C(0.0265);1p34_G(0.0209);3tu4_C(0.039);1p34_C(0.0416);1p3l_C(0.0287);3o62_G(0.0202);1tzy_A(0.0316);3azn_G(0.0341);3o62_C(0.0218);3kuy_C(0.0261);1p3m_G(0.0306);3w99_G(0.0298);1kx5_C(0.0498);3mnn_C(0.0262);2fj7_C(0.0213);3lz1_C(0.0283);3w99_C(0.0271);3lz1_G(0.0266);2fj7_G(0.023);3aze_C(0.049);3mgp_C(0.0261);3rej_G(0.0286);3a6n_C(0.0311);1m18_C(0.0238);3rej_C(0.0267);3a6n_G(0.0344);3mgp_G(0.0261);3uta_C(0.0257);1m18_G(0.0229);3b6f_G(0.0117);3b6f_C(0.0198);1aoi_C(0.0503);3av2_G(0.0294);4ld9_G(0.0114);4ld9_C(0.0129);1p3a_C(0.0236);3azm_C(0.0263);3azi_G(0.0261);1p3a_G(0.028);4j8w_C(0.0236);3azi_C(0.0504);3aze_G(0.0305);1p3i_C(0.0132);3av2_C(0.0244);1aoi_G(0.0393);1p3i_G(0.0273);1p3m_C(0.0235);3azm_G(0.0325);1zla_G(0.0218);3ayw_G(0.0334);3lz0_C(0.0279);1kx4_C(0.031);1zla_C(0.0186);3w98_G(0.0284);1kx4_G(0.0257);3ayw_C(0.043);3lz0_G(0.0256);3w98_C(0.0239);2pyo_G(0.0136);2aro_E(0.0122);2pyo_C(0.0163);3rek_G(0.0279);1hq3_A(0.0294);2aro_A(0.0315);3lja_G(0.0237);2nzd_C(0.0261);3rek_C(0.0301);1hq3_E(0.0156);3mgs_G(0.0236);3mgs_C(0.0279);3lja_C(0.0299);2nqb_G(0.0208);2cv5_G(0.0319);2nqb_C(0.0177);3av1_G(0.0273);2cv5_C(0.0487);1p3b_C(0.0212);3azl_C(0.0436);3azh_G(0.0299);4j8v_C(0.0217);3kwq_C(0.0237);1p3b_G(0.0253);1p3f_C(0.029);3azh_C(0.0316);3kwq_G(0.0278);3av1_C(0.0315);1p3f_G(0.0216);1eqz_A(0.0695);3azl_G(0.0282);1kx3_C(0.0278);1p3o_G(0.0236);3w97_G(0.0323);1kx3_G(0.0301);3azg_C(0.0481);3w97_C(0.0233);3c9k_A(0.0229);3mvd_C(0.0441);3rel_G(0.0231);3c1c_C(0.0282);3rel_C(0.0283);3c1c_G(0.0271);3mgr_G(0.0242);3reh_C(0.0228);3mgr_C(0.0285);3afa_C(0.0521);1s32_G(0.0239);1m1a_G(0.0233);3ut9_G(0.029);1m1a_C(0.0275);3ut9_C(0.0281);1s32_C(0.047);3azk_G(0.0306);3azk_C(0.0454);3azg_G(0.0333);1p3g_C(0.0139);4j8u_C(0.0244);1p3g_G(0.0399);1p3k_C(0.0244);3afa_G(0.0311);1p3k_G(0.0247);1p3o_C(0.0236);3lel_G(0.0193);1p3p_C(0.0272);1p3l_G(0.0398);2hio_A(0.0209);1p3p_G(0.0418);3kxb_C(0.0252);3lel_M(0.0244);3w96_G(0.034);3azf_C(0.0476);3kxb_G(0.031);3w96_C(0.0425);3lel_C(0.0253);3utb_G(0.0247);3c1b_C(0.0243);1m19_G(0.0253);3rei_C(0.0209);3utb_C(0.0281);3mgq_G(0.0246);3c1b_G(0.0277);2f8n_K(0.0357);1m19_C(0.0241);3mgq_C(0.0302) Cluster-exclusive S:1 0.0114 1 1 ucec:1 ENST00000389078 3 3d H2AJ L98 98 153 3b6g_C(0.0233);3b6g_G(0.0201);3azn_C(0.0453);3azj_G(0.0245);1tzy_E(0.0127);3azj_C(0.0387);3azf_G(0.0355);4j8x_C(0.0265);1p34_G(0.0209);3tu4_C(0.039);1p34_C(0.0416);1p3l_C(0.0287);3o62_G(0.0202);1tzy_A(0.0316);3azn_G(0.0341);3o62_C(0.0218);3kuy_C(0.0261);1p3m_G(0.0306);3w99_G(0.0298);1kx5_C(0.0498);3mnn_C(0.0262);2fj7_C(0.0213);3lz1_C(0.0283);3w99_C(0.0271);3lz1_G(0.0266);2fj7_G(0.023);3aze_C(0.049);3mgp_C(0.0261);3rej_G(0.0286);3a6n_C(0.0311);1m18_C(0.0238);3rej_C(0.0267);3a6n_G(0.0344);3mgp_G(0.0261);3uta_C(0.0257);1m18_G(0.0229);3b6f_G(0.0117);3b6f_C(0.0198);1aoi_C(0.0503);3av2_G(0.0294);4ld9_G(0.0114);4ld9_C(0.0129);1p3a_C(0.0236);3azm_C(0.0263);3azi_G(0.0261);1p3a_G(0.028);4j8w_C(0.0236);3azi_C(0.0504);3aze_G(0.0305);1p3i_C(0.0132);3av2_C(0.0244);1aoi_G(0.0393);1p3i_G(0.0273);1p3m_C(0.0235);3azm_G(0.0325);1zla_G(0.0218);3ayw_G(0.0334);3lz0_C(0.0279);1kx4_C(0.031);1zla_C(0.0186);3w98_G(0.0284);1kx4_G(0.0257);3ayw_C(0.043);3lz0_G(0.0256);3w98_C(0.0239);2pyo_G(0.0136);2aro_E(0.0122);2pyo_C(0.0163);3rek_G(0.0279);1hq3_A(0.0294);2aro_A(0.0315);3lja_G(0.0237);2nzd_C(0.0261);3rek_C(0.0301);1hq3_E(0.0156);3mgs_G(0.0236);3mgs_C(0.0279);3lja_C(0.0299);2nqb_G(0.0208);2cv5_G(0.0319);2nqb_C(0.0177);3av1_G(0.0273);2cv5_C(0.0487);1p3b_C(0.0212);3azl_C(0.0436);3azh_G(0.0299);4j8v_C(0.0217);3kwq_C(0.0237);1p3b_G(0.0253);1p3f_C(0.029);3azh_C(0.0316);3kwq_G(0.0278);3av1_C(0.0315);1p3f_G(0.0216);1eqz_A(0.0695);3azl_G(0.0282);1kx3_C(0.0278);1p3o_G(0.0236);3w97_G(0.0323);1kx3_G(0.0301);3azg_C(0.0481);3w97_C(0.0233);3c9k_A(0.0229);3mvd_C(0.0441);3rel_G(0.0231);3c1c_C(0.0282);3rel_C(0.0283);3c1c_G(0.0271);3mgr_G(0.0242);3reh_C(0.0228);3mgr_C(0.0285);3afa_C(0.0521);1s32_G(0.0239);1m1a_G(0.0233);3ut9_G(0.029);1m1a_C(0.0275);3ut9_C(0.0281);1s32_C(0.047);3azk_G(0.0306);3azk_C(0.0454);3azg_G(0.0333);1p3g_C(0.0139);4j8u_C(0.0244);1p3g_G(0.0399);1p3k_C(0.0244);3afa_G(0.0311);1p3k_G(0.0247);1p3o_C(0.0236);3lel_G(0.0193);1p3p_C(0.0272);1p3l_G(0.0398);2hio_A(0.0209);1p3p_G(0.0418);3kxb_C(0.0252);3lel_M(0.0244);3w96_G(0.034);3azf_C(0.0476);3kxb_G(0.031);3w96_C(0.0425);3lel_C(0.0253);3utb_G(0.0247);3c1b_C(0.0243);1m19_G(0.0253);3rei_C(0.0209);3utb_C(0.0281);3mgq_G(0.0246);3c1b_G(0.0277);2f8n_K(0.0357);1m19_C(0.0241);3mgq_C(0.0302) Cluster-exclusive P:1 0.0114 1 1 stad:1 ENST00000389078 3 3d VIM E151 151 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive 0.0117 1 ENST00000224237 5 3d VIM E152 152 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive K:1 0.0117 1 1 skcm:1 ENST00000224237 5 3d VIM E153 153 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive D:1 0.0117 1 1 cesc:1 ENST00000224237 5 3d VIM E156 156 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive K:2 0.0117 2 1 skcm:2 ENST00000224237 5 3d VIM Q160 160 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive K:1 0.0117 1 1 ov:1 ENST00000224237 5 3d VIM V161 161 155 3s4r_B(0.0117);3ssu_B(0.0933) Cluster-exclusive G:1 0.0117 1 1 gbm:1 ENST00000224237 5 3d KIAA0586 H44 44 156 2r7e_B(0.0117) Cluster-exclusive R:1 0.0117 1 1 lihc:1 ENST00000619416 3d KIAA0586 E51 51 156 2r7e_B(0.0117) Cluster-exclusive K:1 0.0117 1 1 lusc:1 ENST00000619416 3d KIAA0586 T69 69 156 2r7e_B(0.0117) Cluster-exclusive K:2 0.0117 2 2 lihc:1|luad:1 ENST00000619416 3d KIAA0586 L73 73 156 2r7e_B(0.0117) Cluster-exclusive F:1 0.0117 1 1 blca:1 ENST00000619416 3d IL13RA2 P35 35 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive L:1 0.0118 1 1 luad:1 ENST00000243213 1 3d IL13RA2 E68 68 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive Q:1 0.0118 1 1 brca:1 ENST00000243213 1 3d IL13RA2 H106 106 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive R:1 0.0118 1 1 coadread:1 ENST00000243213 1 3d IL13RA2 S121 121 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive R:1 0.0118 1 1 stad:1 ENST00000243213 1 3d IL13RA2 S122 122 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive F:1 0.0118 1 1 skcm:1 ENST00000243213 1 3d IL13RA2 W123 123 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive L:1 0.0118 1 1 luad:1 ENST00000243213 1 3d IL13RA2 A124 124 157 3lb6_D(0.0686);3lb6_C(0.0118) Cluster-exclusive T:1 0.0118 1 1 gbm:1 ENST00000243213 1 3d ACOT4 P310 310 158 3k2i_B(0.0141);3k2i_A(0.0119) Cluster-exclusive S:2|L:1 0.0119 3 2 skcm:2|cscc:1 ENST00000326303 4 3d ACOT4 E312 312 158 3k2i_B(0.0141);3k2i_A(0.0119) Cluster-exclusive Q:1|K:2 0.0119 3 3 brca:1|skcm:1|cscc:1 ENST00000326303 4 3d ACOT4 R341 341 158 3k2i_B(0.0141);3k2i_A(0.0119) Cluster-exclusive Q:1|W:1 0.0119 2 2 coadread:1|hnsc:1 ENST00000326303 4 3d ACOT4 Q343 343 158 3k2i_B(0.0141);3k2i_A(0.0119) Cluster-exclusive H:1 0.0119 1 1 luad:1 ENST00000326303 4 3d SOX6 E104 104 159 4jra_D(0.012) Cluster-exclusive D:1 0.012 1 1 luad:1 ENST00000528429 1 3d SOX6 R122 122 159 4jra_D(0.012) Cluster-exclusive C:3|H:1 0.012 4 4 coadread:1|prad:1|ucs:1|lusc:1 ENST00000528429 1 3d SOX6 R123 123 159 4jra_D(0.012) Cluster-exclusive S:1|C:1|H:1 0.012 3 3 paad:1|skcm:1|lihc:1 ENST00000528429 1 3d SOX6 L549 549 159 4jra_D(0.012) Cluster-exclusive F:1 0.012 1 1 all:1 ENST00000528429 1 3d SOX6 Q552 552 159 4jra_D(0.012) Cluster-exclusive L:1 0.012 1 1 lusc:1 ENST00000528429 1 3d SOX6 E140 140 160 4jra_D(0.012) Cluster-exclusive D:1 0.012 1 1 stad:1 ENST00000528429 1 3d SOX6 R144 144 160 4jra_D(0.012) Cluster-exclusive Q:1 0.012 1 1 coadread:1 ENST00000528429 1 3d FGG V293 293 161 1deq_C(0.0121) Cluster-exclusive M:2 0.0121 2 2 coadread:1|gbm:1 ENST00000336098 3 3d FGG L302 302 161 1deq_C(0.0121) Cluster-exclusive I:1 0.0121 1 1 hnsc:1 ENST00000336098 3 3d FGG T303 303 161 1deq_C(0.0121) Cluster-exclusive P:1 0.0121 1 1 esca:1 ENST00000336098 3 3d FGG M336 336 161 1deq_C(0.0121) Cluster-exclusive L:1 0.0121 1 1 cscc:1 ENST00000336098 3 3d MASP1 G298 298 162 4igd_A(0.0123) Cluster-exclusive E:1 0.0123 1 1 cscc:1 ENST00000337774 5 3d MASP1 E300 300 162 4igd_A(0.0123) Cluster-exclusive Q:1|K:2 0.0123 3 3 paad:1|hnsc:1|luad:1 ENST00000337774 5 3d MASP1 K318 318 162 4igd_A(0.0123) Cluster-exclusive T:1 0.0123 1 1 esca:1 ENST00000337774 5 3d MASP1 F321 321 162 4igd_A(0.0123) Cluster-exclusive L:1 0.0123 1 1 luad:1 ENST00000337774 5 3d MASP1 T354 354 162 4igd_A(0.0123) Cluster-exclusive K:1 0.0123 1 1 paad:1 ENST00000337774 5 3d CTPS1 E228 228 163 4eaz_A(0.0123) Cluster-exclusive D:2 0.0123 2 1 ucec:2 ENST00000372616 1 3d CTPS1 E237 237 163 4eaz_A(0.0123) Cluster-exclusive K:1 0.0123 1 1 brca:1 ENST00000372616 1 3d CTPS1 P238 238 163 4eaz_A(0.0123) Cluster-exclusive L:1 0.0123 1 1 cscc:1 ENST00000372616 1 3d CTPS1 E239 239 163 4eaz_A(0.0123) Cluster-exclusive Q:1 0.0123 1 1 luad:1 ENST00000372616 1 3d CTPS1 S300 300 163 4eaz_A(0.0123) Cluster-exclusive C:1 0.0123 1 1 luad:1 ENST00000372616 1 3d CTPS1 L303 303 163 4eaz_A(0.0123) Cluster-exclusive I:1 0.0123 1 1 coadread:1 ENST00000372616 1 3d THADA I519 519 164 4m7r_A(0.0175);4m7r_B(0.0125);2ld4_A(0.0597);2yui_A(0.0371) Cluster-exclusive V:1 0.0125 1 1 lihc:1 ENST00000405006 4 3d THADA D520 520 164 4m7r_A(0.0175);4m7r_B(0.0125);2ld4_A(0.0597);2yui_A(0.0371) Cluster-exclusive H:1 0.0125 1 1 hnsc:1 ENST00000405006 4 3d THADA E524 524 164 4m7r_A(0.0175);4m7r_B(0.0125);2ld4_A(0.0597);2yui_A(0.0371) Cluster-exclusive Q:1|D:1 0.0125 2 2 coadread:1|hnsc:1 ENST00000405006 4 3d THADA V527 527 164 4m7r_A(0.0175);4m7r_B(0.0125);2ld4_A(0.0597);2yui_A(0.0371) Cluster-exclusive G:1 0.0125 1 1 stad:1 ENST00000405006 4 3d THADA Y563 563 164 4m7r_A(0.0175);4m7r_B(0.0125);2ld4_A(0.0597);2yui_A(0.0371) Cluster-exclusive H:1 0.0125 1 1 coadread:1 ENST00000405006 4 3d CDKN2C R39 39 165 1bu9_A(0.0127) Cluster-exclusive T:1 0.0127 1 1 kirc:1 ENST00000262662 1 3d CDKN2C Q43 43 165 1bu9_A(0.0127) Cluster-exclusive H:1 0.0127 1 1 coadread:1 ENST00000262662 1 3d CDKN2C D64 64 165 1bu9_A(0.0127) Cluster-exclusive N:1 0.0127 1 1 ov:1 ENST00000262662 1 3d CDKN2C K66 66 165 1bu9_A(0.0127) Cluster-exclusive E:1 0.0127 1 1 ucec:1 ENST00000262662 1 3d CDKN2C D67 67 165 1bu9_A(0.0127) Cluster-exclusive N:1 0.0127 1 1 thca:1 ENST00000262662 1 3d CDKN2C T69 69 165 1bu9_A(0.0127) Cluster-exclusive A:1 0.0127 1 1 hnsc:1 ENST00000262662 1 3d CDKN2C A72 72 165 1bu9_A(0.0127) Cluster-exclusive T:1 0.0127 1 1 esca:1 ENST00000262662 1 3d CDKN2C E99 99 165 1bu9_A(0.0127) Cluster-exclusive K:1 0.0127 1 1 lusc:1 ENST00000262662 1 3d SRP9 A25 25 166 1e8s_A(0.0127) Cluster-exclusive T:1 0.0127 1 1 kirc:1 ENST00000304786 7 3d SRP9 R26 26 166 1e8s_A(0.0127) Cluster-exclusive H:1 0.0127 1 1 stad:1 ENST00000304786 7 3d SRP9 D44 44 166 1e8s_A(0.0127) Cluster-exclusive V:1 0.0127 1 1 paad:1 ENST00000304786 7 3d HBA2 P115 115 168 2h35_A(0.0135);2h35_C(0.0128) Cluster-exclusive S:1 0.0128 1 1 cscc:1 ENST00000251595 6 3d HBA2 H123 123 168 2h35_A(0.0135);2h35_C(0.0128) Cluster-exclusive Y:1 0.0128 1 1 hnsc:1 ENST00000251595 6 3d HBA2 S125 125 168 2h35_A(0.0135);2h35_C(0.0128) Cluster-exclusive F:1 0.0128 1 1 luad:1 ENST00000251595 6 3d HBA2 L126 126 168 2h35_A(0.0135);2h35_C(0.0128) Cluster-exclusive M:1 0.0128 1 1 hnsc:1 ENST00000251595 6 3d HBA2 D127 127 168 2h35_A(0.0135);2h35_C(0.0128) Cluster-exclusive Y:1 0.0128 1 1 brca:1 ENST00000251595 6 3d RGPD3 N1670 1670 169 3bbp_D(0.0164);3bbp_E(0.0129) Cluster-exclusive K:1 0.0129 1 1 ucec:1 ENST00000409886 3 3d RGPD3 G1671 1671 169 3bbp_D(0.0164);3bbp_E(0.0129) Cluster-exclusive D:1 0.0129 1 1 cscc:1 ENST00000409886 3 3d RGPD3 R1674 1674 169 3bbp_D(0.0164);3bbp_E(0.0129) Cluster-exclusive Q:1 0.0129 1 1 skcm:1 ENST00000409886 3 3d RGPD3 E1675 1675 169 3bbp_D(0.0164);3bbp_E(0.0129) Cluster-exclusive K:2 0.0129 2 1 skcm:2 ENST00000409886 3 3d RGPD3 T1679 1679 169 3bbp_D(0.0164);3bbp_E(0.0129) Cluster-exclusive I:1 0.0129 1 1 ucec:1 ENST00000409886 3 3d RNF111 R957 957 171 2kiz_A(0.013) Cluster-exclusive C:1 0.013 1 1 ov:1 ENST00000557998 1 3d RNF111 L958 958 171 2kiz_A(0.013) Cluster-exclusive I:1 0.013 1 1 coadread:1 ENST00000557998 1 3d RNF111 H962 962 171 2kiz_A(0.013) Cluster-exclusive Y:2 0.013 2 2 coadread:1|esca:1 ENST00000557998 1 3d RNF111 L963 963 171 2kiz_A(0.013) Cluster-exclusive R:1 0.013 1 1 coadread:1 ENST00000557998 1 3d RNF111 V969 969 171 2kiz_A(0.013) Cluster-exclusive G:1 0.013 1 1 stad:1 ENST00000557998 1 3d RNF111 C942 942 172 2kiz_A(0.013) Cluster-exclusive F:1 0.013 1 1 ucec:1 ENST00000557998 1 3d CALM1 I64 64 173 2hf5_A(0.0132) Cluster-exclusive T:1 0.0132 1 1 lihc:1 ENST00000272298 7 3d CALM1 D65 65 173 2hf5_A(0.0132) Cluster-exclusive E:1 0.0132 1 1 lihc:1 ENST00000272298 7 3d CALM1 P67 67 173 2hf5_A(0.0132) Cluster-exclusive L:1 0.0132 1 1 skcm:1 ENST00000272298 7 3d CALM1 L70 70 173 2hf5_A(0.0132) Cluster-exclusive F:2 0.0132 2 2 esca:1|luad:1 ENST00000272298 7 3d CALM1 M73 73 173 2hf5_A(0.0132) Cluster-exclusive I:1 0.0132 1 1 luad:1 ENST00000272298 7 3d CALM1 D81 81 173 2hf5_A(0.0132) Cluster-exclusive N:1 0.0132 1 1 cesc:1 ENST00000272298 7 3d CALM1 E83 83 173 2hf5_A(0.0132) Cluster-exclusive K:1 0.0132 1 1 hnsc:1 ENST00000272298 7 3d HDAC8 M40 40 174 1vkg_B(0.0132) Cluster-exclusive V:1 0.0132 1 1 luad:1 ENST00000373573 3 3d HDAC8 L44 44 174 1vkg_B(0.0132) Cluster-exclusive F:1 0.0132 1 1 luad:1 ENST00000373573 3 3d HDAC8 A49 49 174 1vkg_B(0.0132) Cluster-exclusive V:1 0.0132 1 1 ov:1 ENST00000373573 3 3d HDAC8 R313 313 174 1vkg_B(0.0132) Cluster-exclusive G:1 0.0132 1 1 kirp:1 ENST00000373573 3 3d HDAC8 P332 332 174 1vkg_B(0.0132) Cluster-exclusive Q:1 0.0132 1 1 skcm:1 ENST00000373573 3 3d HDAC8 H334 334 174 1vkg_B(0.0132) Cluster-exclusive Y:1 0.0132 1 1 thca:1 ENST00000373573 3 3d HDAC8 F336 336 174 1vkg_B(0.0132) Cluster-exclusive L:1 0.0132 1 1 coadread:1 ENST00000373573 3 3d KPNB1 R54 54 175 1gcj_A(0.0132);1f59_A(0.0193);1o6p_B(0.0196);1o6o_C(0.0188);1o6o_B(0.0179);1o6p_A(0.0192);1o6o_A(0.0167);1m5n_S(0.0143);1f59_B(0.0165) Cluster-exclusive G:1 0.0132 1 1 lusc:1 ENST00000290158 4 3d KPNB1 L99 99 175 1gcj_A(0.0132);1f59_A(0.0193);1o6p_B(0.0196);1o6o_C(0.0188);1o6o_B(0.0179);1o6p_A(0.0192);1o6o_A(0.0167);1m5n_S(0.0143);1f59_B(0.0165) Cluster-exclusive S:1 0.0132 1 1 stad:1 ENST00000290158 4 3d KPNB1 E102 102 175 1gcj_A(0.0132);1f59_A(0.0193);1o6p_B(0.0196);1o6o_C(0.0188);1o6o_B(0.0179);1o6p_A(0.0192);1o6o_A(0.0167);1m5n_S(0.0143);1f59_B(0.0165) Cluster-exclusive K:2 0.0132 2 2 brca:1|blca:1 ENST00000290158 4 3d KPNB1 Y104 104 175 1gcj_A(0.0132);1f59_A(0.0193);1o6p_B(0.0196);1o6o_C(0.0188);1o6o_B(0.0179);1o6p_A(0.0192);1o6o_A(0.0167);1m5n_S(0.0143);1f59_B(0.0165) Cluster-exclusive C:1 0.0132 1 1 prad:1 ENST00000290158 4 3d KPNB1 A109 109 175 1gcj_A(0.0132);1f59_A(0.0193);1o6p_B(0.0196);1o6o_C(0.0188);1o6o_B(0.0179);1o6p_A(0.0192);1o6o_A(0.0167);1m5n_S(0.0143);1f59_B(0.0165) Cluster-exclusive T:1 0.0132 1 1 luad:1 ENST00000290158 4 3d SUPT5H R813 813 176 2jyw_A(0.0203);2kbo_A(0.0134) Cluster-exclusive H:1 0.0134 1 1 coadread:1 ENST00000432763 2 3d SUPT5H A816 816 176 2jyw_A(0.0203);2kbo_A(0.0134) Cluster-exclusive V:1 0.0134 1 1 skcm:1 ENST00000432763 2 3d SUPT5H Q817 817 176 2jyw_A(0.0203);2kbo_A(0.0134) Cluster-exclusive H:1|K:1 0.0134 2 1 hnsc:2 ENST00000432763 2 3d SUPT5H G819 819 176 2jyw_A(0.0203);2kbo_A(0.0134) Cluster-exclusive W:1 0.0134 1 1 hnsc:1 ENST00000432763 2 3d PIK3CA R38 38 177 2v1y_A(0.0136) Hotspot C:4|S:1|G:1|H:7|L:1 0.0136 14 6 coadread:2|stad:2|gbm:2|ucec:6|lusc:1|cesc:1 ENST00000263967 3 3d PIK3CA E39 39 177 2v1y_A(0.0136) Hotspot-linked G:1|K:4 0.0136 5 2 gbm:1|ucec:4 ENST00000263967 3 3d PIK3CA R88 88 177 2v1y_A(0.0136) Hotspot Q:40 0.0136 40 10 brca:2|coadread:16|prad:1|stad:4|gbm:2|ucs:1|blca:1|hnsc:1|hgg:1|ucec:11 ENST00000263967 3 3d PIK3CA C90 90 177 2v1y_A(0.0136) Hotspot-linked R:1|S:1|G:1|Y:1 0.0136 4 3 gbm:2|blca:1|cesc:1 ENST00000263967 3 3d PIK3CA R93 93 177 2v1y_A(0.0136) Hotspot-linked Q:9|W:6 0.0136 15 6 coadread:1|stad:4|gbm:2|blca:1|ucec:6|cesc:1 ENST00000263967 3 3d KRAS D92 92 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot-linked Y:1 0.0137 1 1 brca:1 ENST00000311936 3 3d PUM1 A1095 1095 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive T:1 0.0138 1 1 paad:1 ENST00000257075 5 3d PUM1 V1096 1096 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive A:1 0.0138 1 1 coadread:1 ENST00000257075 5 3d PUM1 D1099 1099 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive N:1 0.0138 1 1 gbm:1 ENST00000257075 5 3d PUM1 E1100 1100 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive K:1 0.0138 1 1 skcm:1 ENST00000257075 5 3d PUM1 C1102 1102 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive G:1 0.0138 1 1 gbm:1 ENST00000257075 5 3d PUM1 M1104 1104 179 3bsb_B(0.0242);1m8w_A(0.0255);1m8x_A(0.0301);1m8w_B(0.0255);1m8x_B(0.0279);3q0m_B(0.028);3q0o_A(0.026);3q0n_B(0.0272);3q0n_A(0.0254);3q0l_A(0.0267);3q0l_B(0.0259);2yjy_B(0.0227);3bsx_A(0.0258);3bsx_B(0.0277);2yjy_A(0.0259);3q0p_B(0.026);3q0p_A(0.0236);1m8z_A(0.0297);1ib2_A(0.0138) Cluster-exclusive I:1 0.0138 1 1 ucec:1 ENST00000257075 5 3d MAPK1 E81 81 181 3o71_A(0.0183);3erk_A(0.018);4qta_A(0.0189);3qyi_A(0.0201);4iz5_B(0.0193);4iz5_A(0.017);4iz7_C(0.0183);4iz5_D(0.0174);4iz5_C(0.018);4iz7_A(0.0194);4fmq_A(0.0165);3i5z_A(0.0169);3sa0_A(0.0302);4h3q_A(0.0156);4qte_A(0.0204);2ojg_A(0.0171);2gph_A(0.0197);2oji_A(0.018);3tei_A(0.0183);4fv1_A(0.0205);4nif_B(0.0183);3c9w_A(0.0185);4nif_E(0.0179);1tvo_A(0.0181);3w55_A(0.017);4g6o_A(0.0193);2y9q_A(0.017);4fv9_A(0.0191);3r63_A(0.0196);2erk_A(0.0174);4fv7_A(0.0179);4fv5_A(0.014);4fv3_A(0.0191);3zu7_A(0.0175);3zuv_A(0.0161);1wzy_A(0.015);4fux_A(0.0176);1gol_A(0.0174);4h3p_D(0.016);4iza_C(0.0178);4h3p_A(0.0166);4o6e_A(0.0156);2ojj_A(0.0213);4fv0_A(0.0173);4iza_A(0.0176);4gt3_A(0.0179);4erk_A(0.0195);1erk_A(0.016);2fys_A(0.0198);4fv8_A(0.0167);2fys_B(0.0168);3i60_A(0.0168);4fv6_A(0.0146);4fv4_A(0.0152);4gva_A(0.0206);4fv2_A(0.0187) Hotspot-linked K:2 0.014 2 2 brca:1|hnsc:1 ENST00000215832 6 3d MAPK1 R135 135 181 3o71_A(0.0183);3erk_A(0.018);4qta_A(0.0189);3qyi_A(0.0201);4iz5_B(0.0193);4iz5_A(0.017);4iz7_C(0.0183);4iz5_D(0.0174);4iz5_C(0.018);4iz7_A(0.0194);4fmq_A(0.0165);3i5z_A(0.0169);3sa0_A(0.0302);4h3q_A(0.0156);4qte_A(0.0204);2ojg_A(0.0171);2gph_A(0.0197);2oji_A(0.018);3tei_A(0.0183);4fv1_A(0.0205);4nif_B(0.0183);3c9w_A(0.0185);4nif_E(0.0179);1tvo_A(0.0181);3w55_A(0.017);4g6o_A(0.0193);2y9q_A(0.017);4fv9_A(0.0191);3r63_A(0.0196);2erk_A(0.0174);4fv7_A(0.0179);4fv5_A(0.014);4fv3_A(0.0191);3zu7_A(0.0175);3zuv_A(0.0161);1wzy_A(0.015);4fux_A(0.0176);1gol_A(0.0174);4h3p_D(0.016);4iza_C(0.0178);4h3p_A(0.0166);4o6e_A(0.0156);2ojj_A(0.0213);4fv0_A(0.0173);4iza_A(0.0176);4gt3_A(0.0179);4erk_A(0.0195);1erk_A(0.016);2fys_A(0.0198);4fv8_A(0.0167);2fys_B(0.0168);3i60_A(0.0168);4fv6_A(0.0146);4fv4_A(0.0152);4gva_A(0.0206);4fv2_A(0.0187) Hotspot-linked K:1 0.014 1 1 cesc:1 ENST00000215832 6 3d MAPK1 G136 136 181 3o71_A(0.0183);3erk_A(0.018);4qta_A(0.0189);3qyi_A(0.0201);4iz5_B(0.0193);4iz5_A(0.017);4iz7_C(0.0183);4iz5_D(0.0174);4iz5_C(0.018);4iz7_A(0.0194);4fmq_A(0.0165);3i5z_A(0.0169);3sa0_A(0.0302);4h3q_A(0.0156);4qte_A(0.0204);2ojg_A(0.0171);2gph_A(0.0197);2oji_A(0.018);3tei_A(0.0183);4fv1_A(0.0205);4nif_B(0.0183);3c9w_A(0.0185);4nif_E(0.0179);1tvo_A(0.0181);3w55_A(0.017);4g6o_A(0.0193);2y9q_A(0.017);4fv9_A(0.0191);3r63_A(0.0196);2erk_A(0.0174);4fv7_A(0.0179);4fv5_A(0.014);4fv3_A(0.0191);3zu7_A(0.0175);3zuv_A(0.0161);1wzy_A(0.015);4fux_A(0.0176);1gol_A(0.0174);4h3p_D(0.016);4iza_C(0.0178);4h3p_A(0.0166);4o6e_A(0.0156);2ojj_A(0.0213);4fv0_A(0.0173);4iza_A(0.0176);4gt3_A(0.0179);4erk_A(0.0195);1erk_A(0.016);2fys_A(0.0198);4fv8_A(0.0167);2fys_B(0.0168);3i60_A(0.0168);4fv6_A(0.0146);4fv4_A(0.0152);4gva_A(0.0206);4fv2_A(0.0187) Hotspot-linked E:1 0.014 1 1 stad:1 ENST00000215832 6 3d MAPK1 D321 321 181 3o71_A(0.0183);3erk_A(0.018);4qta_A(0.0189);3qyi_A(0.0201);4iz5_B(0.0193);4iz5_A(0.017);4iz7_C(0.0183);4iz5_D(0.0174);4iz5_C(0.018);4iz7_A(0.0194);4fmq_A(0.0165);3i5z_A(0.0169);3sa0_A(0.0302);4h3q_A(0.0156);4qte_A(0.0204);2ojg_A(0.0171);2gph_A(0.0197);2oji_A(0.018);3tei_A(0.0183);4fv1_A(0.0205);4nif_B(0.0183);3c9w_A(0.0185);4nif_E(0.0179);1tvo_A(0.0181);3w55_A(0.017);4g6o_A(0.0193);2y9q_A(0.017);4fv9_A(0.0191);3r63_A(0.0196);2erk_A(0.0174);4fv7_A(0.0179);4fv5_A(0.014);4fv3_A(0.0191);3zu7_A(0.0175);3zuv_A(0.0161);1wzy_A(0.015);4fux_A(0.0176);1gol_A(0.0174);4h3p_D(0.016);4iza_C(0.0178);4h3p_A(0.0166);4o6e_A(0.0156);2ojj_A(0.0213);4fv0_A(0.0173);4iza_A(0.0176);4gt3_A(0.0179);4erk_A(0.0195);1erk_A(0.016);2fys_A(0.0198);4fv8_A(0.0167);2fys_B(0.0168);3i60_A(0.0168);4fv6_A(0.0146);4fv4_A(0.0152);4gva_A(0.0206);4fv2_A(0.0187) Hotspot-linked V:1|N:2 0.014 3 3 hnsc:1|skcm:1|cesc:1 ENST00000215832 6 3d MAPK1 E322 322 181 3o71_A(0.0183);3erk_A(0.018);4qta_A(0.0189);3qyi_A(0.0201);4iz5_B(0.0193);4iz5_A(0.017);4iz7_C(0.0183);4iz5_D(0.0174);4iz5_C(0.018);4iz7_A(0.0194);4fmq_A(0.0165);3i5z_A(0.0169);3sa0_A(0.0302);4h3q_A(0.0156);4qte_A(0.0204);2ojg_A(0.0171);2gph_A(0.0197);2oji_A(0.018);3tei_A(0.0183);4fv1_A(0.0205);4nif_B(0.0183);3c9w_A(0.0185);4nif_E(0.0179);1tvo_A(0.0181);3w55_A(0.017);4g6o_A(0.0193);2y9q_A(0.017);4fv9_A(0.0191);3r63_A(0.0196);2erk_A(0.0174);4fv7_A(0.0179);4fv5_A(0.014);4fv3_A(0.0191);3zu7_A(0.0175);3zuv_A(0.0161);1wzy_A(0.015);4fux_A(0.0176);1gol_A(0.0174);4h3p_D(0.016);4iza_C(0.0178);4h3p_A(0.0166);4o6e_A(0.0156);2ojj_A(0.0213);4fv0_A(0.0173);4iza_A(0.0176);4gt3_A(0.0179);4erk_A(0.0195);1erk_A(0.016);2fys_A(0.0198);4fv8_A(0.0167);2fys_B(0.0168);3i60_A(0.0168);4fv6_A(0.0146);4fv4_A(0.0152);4gva_A(0.0206);4fv2_A(0.0187) Hotspot K:15 0.014 15 3 blca:1|hnsc:7|cesc:7 ENST00000215832 6 3d ATP1A3 R340 340 182 2zxe_A(0.014) Cluster-exclusive C:1 0.014 1 1 gbm:1 ENST00000302102 5 3d ATP1A3 M341 341 182 2zxe_A(0.014) Cluster-exclusive I:1 0.014 1 1 lusc:1 ENST00000302102 5 3d ATP1A3 R343 343 182 2zxe_A(0.014) Cluster-exclusive Q:1 0.014 1 1 ucec:1 ENST00000302102 5 3d ATP1A3 K344 344 182 2zxe_A(0.014) Cluster-exclusive M:1|N:1 0.014 2 2 stad:1|lihc:1 ENST00000302102 5 3d ATP1A3 N345 345 182 2zxe_A(0.014) Cluster-exclusive T:1 0.014 1 1 acc:1 ENST00000302102 5 3d ATP1A3 D742 742 182 2zxe_A(0.014) Cluster-exclusive N:1 0.014 1 1 skcm:1 ENST00000302102 5 3d ATP1A3 N744 744 182 2zxe_A(0.014) Cluster-exclusive T:1 0.014 1 1 stad:1 ENST00000302102 5 3d NRAS G12 12 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot A:3|R:2|C:7|S:3|D:18|V:3 0.0141 36 7 mmyl:3|coadread:15|stad:1|laml:6|skcm:7|ucec:2|mds:2 ENST00000369535 4 3d NRAS G13 13 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot R:10|D:11|V:1 0.0141 22 9 mmyl:5|coadread:3|stad:1|blca:1|dlbc:1|laml:5|mbl:1|skcm:3|mds:2 ENST00000369535 4 3d NRAS P34 34 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot-linked L:1 0.0141 1 1 skcm:1 ENST00000369535 4 3d NRAS G60 60 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot-linked 0.0141 1 ENST00000369535 4 3d NRAS Q61 61 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot P:1|R:113|H:16|K:73|L:27 0.0141 230 17 acc:1|mmyl:27|npc:1|coadread:16|cll:4|thca:34|laml:6|blca:3|ov:2|lihc:1|lgg:1|kich:1|stad:2|gbm:1|skcm:122|ucec:4|luad:4 ENST00000369535 4 3d NRAS Y64 64 183 3rs4_A(0.0143);3rs2_A(0.0167);3rs3_A(0.017);3rs7_A(0.018);3v4f_A(0.0141);3l8y_A(0.0167);4dls_A(0.0175);6q21_A(0.0161);3rrz_A(0.0164);4dlv_A(0.0178);4dlx_A(0.0184);4dly_A(0.0162);4dlz_A(0.0183);1nvw_Q(0.0168);4dlr_A(0.0182);3rs0_A(0.0167);3rso_A(0.0174) Hotspot-linked D:1 0.0141 1 1 mmyl:1 ENST00000369535 4 3d CARM1 D190 190 184 2v74_H(0.0168);2y1x_D(0.0249);3b3f_A(0.0238);3b3g_A(0.023);2y1w_D(0.024);2y1x_C(0.025);2v74_F(0.0181);2y1w_C(0.0278);2y1x_B(0.0277);2y1x_A(0.0245);2y1w_B(0.0269);4ikp_D(0.0141);4ikp_C(0.0171);3b3j_A(0.0155);2v74_D(0.0171);2v74_B(0.0163);2y1w_A(0.0247);2v7e_A(0.0205) Cluster-exclusive H:1 0.0141 1 1 esca:1 ENST00000327064 4 3d CARM1 A202 202 184 2v74_H(0.0168);2y1x_D(0.0249);3b3f_A(0.0238);3b3g_A(0.023);2y1w_D(0.024);2y1x_C(0.025);2v74_F(0.0181);2y1w_C(0.0278);2y1x_B(0.0277);2y1x_A(0.0245);2y1w_B(0.0269);4ikp_D(0.0141);4ikp_C(0.0171);3b3j_A(0.0155);2v74_D(0.0171);2v74_B(0.0163);2y1w_A(0.0247);2v7e_A(0.0205) Cluster-exclusive V:13 0.0141 13 5 paad:5|gbm:2|hnsc:2|skcm:2|luad:2 ENST00000327064 4 3d CARM1 A203 203 184 2v74_H(0.0168);2y1x_D(0.0249);3b3f_A(0.0238);3b3g_A(0.023);2y1w_D(0.024);2y1x_C(0.025);2v74_F(0.0181);2y1w_C(0.0278);2y1x_B(0.0277);2y1x_A(0.0245);2y1w_B(0.0269);4ikp_D(0.0141);4ikp_C(0.0171);3b3j_A(0.0155);2v74_D(0.0171);2v74_B(0.0163);2y1w_A(0.0247);2v7e_A(0.0205) Cluster-exclusive P:1|V:1 0.0141 2 2 brca:1|luad:1 ENST00000327064 4 3d CARM1 R208 208 184 2v74_H(0.0168);2y1x_D(0.0249);3b3f_A(0.0238);3b3g_A(0.023);2y1w_D(0.024);2y1x_C(0.025);2v74_F(0.0181);2y1w_C(0.0278);2y1x_B(0.0277);2y1x_A(0.0245);2y1w_B(0.0269);4ikp_D(0.0141);4ikp_C(0.0171);3b3j_A(0.0155);2v74_D(0.0171);2v74_B(0.0163);2y1w_A(0.0247);2v7e_A(0.0205) Cluster-exclusive Q:1 0.0141 1 1 ucec:1 ENST00000327064 4 3d CARM1 I210 210 184 2v74_H(0.0168);2y1x_D(0.0249);3b3f_A(0.0238);3b3g_A(0.023);2y1w_D(0.024);2y1x_C(0.025);2v74_F(0.0181);2y1w_C(0.0278);2y1x_B(0.0277);2y1x_A(0.0245);2y1w_B(0.0269);4ikp_D(0.0141);4ikp_C(0.0171);3b3j_A(0.0155);2v74_D(0.0171);2v74_B(0.0163);2y1w_A(0.0247);2v7e_A(0.0205) Cluster-exclusive M:1 0.0141 1 1 ov:1 ENST00000327064 4 3d CR1 L49 49 185 2mcz_A(0.0141) Cluster-exclusive F:1 0.0141 1 1 stad:1 ENST00000367051 1 3d CR1 A52 52 185 2mcz_A(0.0141) Cluster-exclusive S:1 0.0141 1 1 stad:1 ENST00000367051 1 3d CR1 C73 73 185 2mcz_A(0.0141) Cluster-exclusive R:1 0.0141 1 1 stad:1 ENST00000367051 1 3d CR1 R74 74 185 2mcz_A(0.0141) Cluster-exclusive C:1|H:1 0.0141 2 2 coadread:1|stad:1 ENST00000367051 1 3d CR1 G79 79 185 2mcz_A(0.0141) Cluster-exclusive V:1 0.0141 1 1 esca:1 ENST00000367051 1 3d CR1 P81 81 185 2mcz_A(0.0141) Cluster-exclusive E:1 0.0141 1 1 blca:1 ENST00000367051 1 3d CR1 C99 99 185 2mcz_A(0.0141) Cluster-exclusive G:1 0.0141 1 1 cscc:1 ENST00000367051 1 3d CR1 R101 101 185 2mcz_A(0.0141) Cluster-exclusive C:2 0.0141 2 2 coadread:1|lgg:1 ENST00000367051 1 3d UQCRFS1 E153 153 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive K:2 0.0141 2 1 coadread:2 ENST00000304863 4 3d UQCRFS1 V176 176 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive A:1 0.0141 1 1 paad:1 ENST00000304863 4 3d UQCRFS1 F265 265 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive L:1 0.0141 1 1 ucec:1 ENST00000304863 4 3d UQCRFS1 M270 270 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive V:1 0.0141 1 1 hnsc:1 ENST00000304863 4 3d UQCRFS1 V271 271 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive A:1 0.0141 1 1 stad:1 ENST00000304863 4 3d UQCRFS1 I272 272 186 2bcc_E(0.0141);1rie_A(0.0216) Cluster-exclusive T:1 0.0141 1 1 coadread:1 ENST00000304863 4 3d PIK3R1 D569 569 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot-linked G:1 0.0142 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Y452 452 189 4l1b_B(0.0142) Cluster-exclusive C:2|H:1|N:1 0.0142 4 3 esca:1|hnsc:1|ucec:2 ENST00000274335 5 3d PIK3R1 K459 459 189 4l1b_B(0.0142) Hotspot-linked E:1 0.0142 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 189 4l1b_B(0.0142) Hotspot-linked P:1 0.0142 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 189 4l1b_B(0.0142) Hotspot-linked R:1 0.0142 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 189 4l1b_B(0.0142) Hotspot-linked P:3 0.0142 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 189 4l1b_B(0.0142) Hotspot-linked T:1|I:2 0.0142 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d PIK3R1 T576 576 189 4l1b_B(0.0142) Cluster-exclusive M:1 0.0142 1 1 esca:1 ENST00000274335 5 3d PIK3R1 R577 577 189 4l1b_B(0.0142) Cluster-exclusive G:1 0.0142 1 1 lihc:1 ENST00000274335 5 3d FHL5 K53 53 190 2dlu_A(0.0142) Cluster-exclusive M:1 0.0142 1 1 blca:1 ENST00000326771 2 3d FHL5 H63 63 190 2dlu_A(0.0142) Cluster-exclusive Y:1 0.0142 1 1 luad:1 ENST00000326771 2 3d FHL5 A83 83 190 2dlu_A(0.0142) Cluster-exclusive S:1|D:1|G:1 0.0142 3 3 hnsc:1|nbl:1|luad:1 ENST00000326771 2 3d FHL5 K84 84 190 2dlu_A(0.0142) Cluster-exclusive N:1 0.0142 1 1 coadread:1 ENST00000326771 2 3d FHL5 R87 87 190 2dlu_A(0.0142) Cluster-exclusive C:1|H:1|L:1 0.0142 3 3 coadread:1|stad:1|luad:1 ENST00000326771 2 3d FHL5 C93 93 190 2dlu_A(0.0142) Cluster-exclusive R:1 0.0142 1 1 stad:1 ENST00000326771 2 3d FHL5 R114 114 190 2dlu_A(0.0142) Cluster-exclusive G:1|L:2 0.0142 3 2 lihc:1|lusc:2 ENST00000326771 2 3d FHL5 M116 116 190 2dlu_A(0.0142) Cluster-exclusive I:1 0.0142 1 1 cscc:1 ENST00000326771 2 3d TP53I3 G141 141 191 2oby_C(0.0164);2oby_D(0.0144);2oby_E(0.0169);2oby_A(0.0177);2oby_B(0.0172);2j8z_A(0.0196) Cluster-exclusive E:1 0.0144 1 1 skcm:1 ENST00000238721 4 3d TP53I3 D142 142 191 2oby_C(0.0164);2oby_D(0.0144);2oby_E(0.0169);2oby_A(0.0177);2oby_B(0.0172);2j8z_A(0.0196) Cluster-exclusive H:1 0.0144 1 1 brca:1 ENST00000238721 4 3d TP53I3 R162 162 191 2oby_C(0.0164);2oby_D(0.0144);2oby_E(0.0169);2oby_A(0.0177);2oby_B(0.0172);2j8z_A(0.0196) Cluster-exclusive Q:2 0.0144 2 2 blca:1|cscc:1 ENST00000238721 4 3d TP53I3 G165 165 191 2oby_C(0.0164);2oby_D(0.0144);2oby_E(0.0169);2oby_A(0.0177);2oby_B(0.0172);2j8z_A(0.0196) Cluster-exclusive E:1 0.0144 1 1 brca:1 ENST00000238721 4 3d TP53I3 A166 166 191 2oby_C(0.0164);2oby_D(0.0144);2oby_E(0.0169);2oby_A(0.0177);2oby_B(0.0172);2j8z_A(0.0196) Cluster-exclusive T:1 0.0144 1 1 gbm:1 ENST00000238721 4 3d ITPR2 G12 12 192 3jrr_B(0.0144);3jrr_A(0.0167) Cluster-exclusive V:1 0.0144 1 1 kirp:1 ENST00000381340 3 3d ITPR2 D13 13 192 3jrr_B(0.0144);3jrr_A(0.0167) Cluster-exclusive G:1 0.0144 1 1 lgg:1 ENST00000381340 3 3d ITPR2 I14 14 192 3jrr_B(0.0144);3jrr_A(0.0167) Cluster-exclusive M:1 0.0144 1 1 ov:1 ENST00000381340 3 3d ITPR2 S16 16 192 3jrr_B(0.0144);3jrr_A(0.0167) Cluster-exclusive F:1 0.0144 1 1 lgg:1 ENST00000381340 3 3d SETBP1 K939 939 193 2x4r_A(0.0175);3ffc_F(0.0608);3ffc_A(0.0616);3qdj_A(0.0173);1agb_A(0.0518);3ln5_A(0.0629);1s9y_A(0.0186);1i7r_A(0.0179);1agd_A(0.0624);3ft3_A(0.0663);2gt9_A(0.0203);1s9w_A(0.021);3gsn_H(0.0192);3gsv_A(0.0661);3o3d_A(0.0217);3gsx_A(0.0205);1t1y_A(0.019);1agf_A(0.0837);3mr9_A(0.0193);4jqv_A(0.0623);2f54_A(0.0203);1ao7_A(0.0187);3gsr_A(0.019);1hhh_A(0.0159);3mrr_A(0.0159);3sjv_A(0.0444);3v5k_A(0.0166);3mrn_A(0.0223);3hpj_A(0.0211);3mrp_A(0.0649);3mrj_A(0.0657);3mrl_A(0.0184);3bvn_A(0.0561);3bgm_A(0.0184);3mrf_A(0.0161);2av7_A(0.0174);3mrh_A(0.0169);1duz_A(0.0187);3mrb_A(0.0637);2c7u_A(0.0154);3mrd_A(0.0176);2av1_A(0.0204);3bh8_A(0.0207);1qsf_A(0.018);1mi5_A(0.0529);1i7u_A(0.0171);3sko_A(0.0634);3ft2_A(0.0606);3skm_A(0.0585);3d25_A(0.0203);3utt_A(0.023);3ln4_A(0.064);1agc_A(0.0615);1s9x_A(0.0187);3ft4_A(0.0702);3gsu_A(0.0694);1bd2_A(0.0192);3gsw_A(0.0201);1i1f_A(0.0183);1age_A(0.0558);1qrn_A(0.0182);1m05_A(0.0564);3bhb_A(0.0147);3gso_A(0.0188);3to2_A(0.0172);3gsq_A(0.0211);1hhg_A(0.0235);3bxn_A(0.0611);3mro_A(0.059);3mrq_A(0.0189);3mrk_A(0.0217);3mrm_A(0.0582);3h9s_A(0.0183);3mrg_A(0.019);3mri_A(0.0156);3mrc_A(0.0211);4k7f_A(0.0658);3mre_A(0.016);1t20_A(0.0198);2j8u_A(0.0178);3spv_A(0.062);3hla_A(0.0622);1i1y_A(0.0189);1qse_A(0.022) Cluster-exclusive M:1|N:1 0.0147 2 2 coadread:1|kirp:1 ENST00000282030 5 3d SETBP1 R942 942 193 2x4r_A(0.0175);3ffc_F(0.0608);3ffc_A(0.0616);3qdj_A(0.0173);1agb_A(0.0518);3ln5_A(0.0629);1s9y_A(0.0186);1i7r_A(0.0179);1agd_A(0.0624);3ft3_A(0.0663);2gt9_A(0.0203);1s9w_A(0.021);3gsn_H(0.0192);3gsv_A(0.0661);3o3d_A(0.0217);3gsx_A(0.0205);1t1y_A(0.019);1agf_A(0.0837);3mr9_A(0.0193);4jqv_A(0.0623);2f54_A(0.0203);1ao7_A(0.0187);3gsr_A(0.019);1hhh_A(0.0159);3mrr_A(0.0159);3sjv_A(0.0444);3v5k_A(0.0166);3mrn_A(0.0223);3hpj_A(0.0211);3mrp_A(0.0649);3mrj_A(0.0657);3mrl_A(0.0184);3bvn_A(0.0561);3bgm_A(0.0184);3mrf_A(0.0161);2av7_A(0.0174);3mrh_A(0.0169);1duz_A(0.0187);3mrb_A(0.0637);2c7u_A(0.0154);3mrd_A(0.0176);2av1_A(0.0204);3bh8_A(0.0207);1qsf_A(0.018);1mi5_A(0.0529);1i7u_A(0.0171);3sko_A(0.0634);3ft2_A(0.0606);3skm_A(0.0585);3d25_A(0.0203);3utt_A(0.023);3ln4_A(0.064);1agc_A(0.0615);1s9x_A(0.0187);3ft4_A(0.0702);3gsu_A(0.0694);1bd2_A(0.0192);3gsw_A(0.0201);1i1f_A(0.0183);1age_A(0.0558);1qrn_A(0.0182);1m05_A(0.0564);3bhb_A(0.0147);3gso_A(0.0188);3to2_A(0.0172);3gsq_A(0.0211);1hhg_A(0.0235);3bxn_A(0.0611);3mro_A(0.059);3mrq_A(0.0189);3mrk_A(0.0217);3mrm_A(0.0582);3h9s_A(0.0183);3mrg_A(0.019);3mri_A(0.0156);3mrc_A(0.0211);4k7f_A(0.0658);3mre_A(0.016);1t20_A(0.0198);2j8u_A(0.0178);3spv_A(0.062);3hla_A(0.0622);1i1y_A(0.0189);1qse_A(0.022) Cluster-exclusive Q:1|W:1 0.0147 2 2 coadread:1|skcm:1 ENST00000282030 5 3d SETBP1 S944 944 193 2x4r_A(0.0175);3ffc_F(0.0608);3ffc_A(0.0616);3qdj_A(0.0173);1agb_A(0.0518);3ln5_A(0.0629);1s9y_A(0.0186);1i7r_A(0.0179);1agd_A(0.0624);3ft3_A(0.0663);2gt9_A(0.0203);1s9w_A(0.021);3gsn_H(0.0192);3gsv_A(0.0661);3o3d_A(0.0217);3gsx_A(0.0205);1t1y_A(0.019);1agf_A(0.0837);3mr9_A(0.0193);4jqv_A(0.0623);2f54_A(0.0203);1ao7_A(0.0187);3gsr_A(0.019);1hhh_A(0.0159);3mrr_A(0.0159);3sjv_A(0.0444);3v5k_A(0.0166);3mrn_A(0.0223);3hpj_A(0.0211);3mrp_A(0.0649);3mrj_A(0.0657);3mrl_A(0.0184);3bvn_A(0.0561);3bgm_A(0.0184);3mrf_A(0.0161);2av7_A(0.0174);3mrh_A(0.0169);1duz_A(0.0187);3mrb_A(0.0637);2c7u_A(0.0154);3mrd_A(0.0176);2av1_A(0.0204);3bh8_A(0.0207);1qsf_A(0.018);1mi5_A(0.0529);1i7u_A(0.0171);3sko_A(0.0634);3ft2_A(0.0606);3skm_A(0.0585);3d25_A(0.0203);3utt_A(0.023);3ln4_A(0.064);1agc_A(0.0615);1s9x_A(0.0187);3ft4_A(0.0702);3gsu_A(0.0694);1bd2_A(0.0192);3gsw_A(0.0201);1i1f_A(0.0183);1age_A(0.0558);1qrn_A(0.0182);1m05_A(0.0564);3bhb_A(0.0147);3gso_A(0.0188);3to2_A(0.0172);3gsq_A(0.0211);1hhg_A(0.0235);3bxn_A(0.0611);3mro_A(0.059);3mrq_A(0.0189);3mrk_A(0.0217);3mrm_A(0.0582);3h9s_A(0.0183);3mrg_A(0.019);3mri_A(0.0156);3mrc_A(0.0211);4k7f_A(0.0658);3mre_A(0.016);1t20_A(0.0198);2j8u_A(0.0178);3spv_A(0.062);3hla_A(0.0622);1i1y_A(0.0189);1qse_A(0.022) Cluster-exclusive R:1|N:1 0.0147 2 2 stad:1|skcm:1 ENST00000282030 5 3d SETBP1 R948 948 193 2x4r_A(0.0175);3ffc_F(0.0608);3ffc_A(0.0616);3qdj_A(0.0173);1agb_A(0.0518);3ln5_A(0.0629);1s9y_A(0.0186);1i7r_A(0.0179);1agd_A(0.0624);3ft3_A(0.0663);2gt9_A(0.0203);1s9w_A(0.021);3gsn_H(0.0192);3gsv_A(0.0661);3o3d_A(0.0217);3gsx_A(0.0205);1t1y_A(0.019);1agf_A(0.0837);3mr9_A(0.0193);4jqv_A(0.0623);2f54_A(0.0203);1ao7_A(0.0187);3gsr_A(0.019);1hhh_A(0.0159);3mrr_A(0.0159);3sjv_A(0.0444);3v5k_A(0.0166);3mrn_A(0.0223);3hpj_A(0.0211);3mrp_A(0.0649);3mrj_A(0.0657);3mrl_A(0.0184);3bvn_A(0.0561);3bgm_A(0.0184);3mrf_A(0.0161);2av7_A(0.0174);3mrh_A(0.0169);1duz_A(0.0187);3mrb_A(0.0637);2c7u_A(0.0154);3mrd_A(0.0176);2av1_A(0.0204);3bh8_A(0.0207);1qsf_A(0.018);1mi5_A(0.0529);1i7u_A(0.0171);3sko_A(0.0634);3ft2_A(0.0606);3skm_A(0.0585);3d25_A(0.0203);3utt_A(0.023);3ln4_A(0.064);1agc_A(0.0615);1s9x_A(0.0187);3ft4_A(0.0702);3gsu_A(0.0694);1bd2_A(0.0192);3gsw_A(0.0201);1i1f_A(0.0183);1age_A(0.0558);1qrn_A(0.0182);1m05_A(0.0564);3bhb_A(0.0147);3gso_A(0.0188);3to2_A(0.0172);3gsq_A(0.0211);1hhg_A(0.0235);3bxn_A(0.0611);3mro_A(0.059);3mrq_A(0.0189);3mrk_A(0.0217);3mrm_A(0.0582);3h9s_A(0.0183);3mrg_A(0.019);3mri_A(0.0156);3mrc_A(0.0211);4k7f_A(0.0658);3mre_A(0.016);1t20_A(0.0198);2j8u_A(0.0178);3spv_A(0.062);3hla_A(0.0622);1i1y_A(0.0189);1qse_A(0.022) Cluster-exclusive S:1|C:1|H:1 0.0147 3 3 stad:1|hnsc:1|luad:1 ENST00000282030 5 3d ERBIN E463 463 194 3iyg_E(0.0147) Cluster-exclusive Q:1|K:1 0.0147 2 2 skcm:1|cesc:1 ENST00000284037 5 3d ERBIN D465 465 194 3iyg_E(0.0147) Cluster-exclusive G:1|Y:1 0.0147 2 2 blca:1|lihc:1 ENST00000284037 5 3d ERBIN E466 466 194 3iyg_E(0.0147) Cluster-exclusive K:2 0.0147 2 2 brca:1|blca:1 ENST00000284037 5 3d HIC2 H551 551 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive R:1 0.0148 1 1 kirc:1 ENST00000407464 2 3d HIC2 F561 561 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive L:1 0.0148 1 1 lihc:1 ENST00000407464 2 3d HIC2 A562 562 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive T:1 0.0148 1 1 paad:1 ENST00000407464 2 3d HIC2 D564 564 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive N:1 0.0148 1 1 skcm:1 ENST00000407464 2 3d HIC2 G567 567 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive D:1 0.0148 1 1 ucec:1 ENST00000407464 2 3d HIC2 R569 569 195 2vcv_A(0.0406);3ik9_B(0.0187);2vct_A(0.0242);3zfb_B(0.0172);1pkz_A(0.0189);3zfb_A(0.0186);3ik9_F(0.0199);1pkz_B(0.0181);3i6a_A(0.0211);1k3l_B(0.0153);1k3l_A(0.0148);1usb_B(0.0162);1gsf_A(0.0195);1usb_A(0.0203);1pkw_A(0.0179);3u6v_B(0.0177);1gsd_A(0.0185);1k3y_A(0.0186);4hj2_A(0.0165);4hj2_B(0.019);4acs_A(0.0225);1pl1_A(0.0184) Cluster-exclusive H:1 0.0148 1 1 brca:1 ENST00000407464 2 3d KRAS D33 33 196 1aa9_A(0.0154) Hotspot-linked E:1 0.0154 1 1 luad:1 ENST00000311936 3 3d KRAS I36 36 196 1aa9_A(0.0154) Hotspot-linked L:1|M:2 0.0154 3 3 mmyl:1|esca:1|laml:1 ENST00000311936 3 3d TUBB2B A9 9 197 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4i55_B(0.0524);4f61_H(0.0322);1tub_B(0.0308);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3j1t_C(0.0154);4drx_B(0.0295);3ut5_B(0.0389);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);1ia0_B(0.0314);2hxf_B(0.0261);2xrp_A(0.0292);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);3ryc_B(0.0392);2hxh_B(0.029);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryf_D(0.0302);3ryh_B(0.0352);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive V:1 0.0154 1 1 paad:1 ENST00000259818 7 3d TUBB2B C12 12 197 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4i55_B(0.0524);4f61_H(0.0322);1tub_B(0.0308);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3j1t_C(0.0154);4drx_B(0.0295);3ut5_B(0.0389);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);1ia0_B(0.0314);2hxf_B(0.0261);2xrp_A(0.0292);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);3ryc_B(0.0392);2hxh_B(0.029);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryf_D(0.0302);3ryh_B(0.0352);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive G:1 0.0154 1 1 brca:1 ENST00000259818 7 3d TUBB2B G13 13 197 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4i55_B(0.0524);4f61_H(0.0322);1tub_B(0.0308);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3j1t_C(0.0154);4drx_B(0.0295);3ut5_B(0.0389);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);1ia0_B(0.0314);2hxf_B(0.0261);2xrp_A(0.0292);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);3ryc_B(0.0392);2hxh_B(0.029);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryf_D(0.0302);3ryh_B(0.0352);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive C:1 0.0154 1 1 lihc:1 ENST00000259818 7 3d TUBB2B N14 14 197 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4i55_B(0.0524);4f61_H(0.0322);1tub_B(0.0308);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3j1t_C(0.0154);4drx_B(0.0295);3ut5_B(0.0389);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);1ia0_B(0.0314);2hxf_B(0.0261);2xrp_A(0.0292);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);3ryc_B(0.0392);2hxh_B(0.029);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryf_D(0.0302);3ryh_B(0.0352);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive S:1 0.0154 1 1 kirc:1 ENST00000259818 7 3d TUBB2B V169 169 197 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4i55_B(0.0524);4f61_H(0.0322);1tub_B(0.0308);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3j1t_C(0.0154);4drx_B(0.0295);3ut5_B(0.0389);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);1ia0_B(0.0314);2hxf_B(0.0261);2xrp_A(0.0292);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);3ryc_B(0.0392);2hxh_B(0.029);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryf_D(0.0302);3ryh_B(0.0352);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive I:1 0.0154 1 1 kirc:1 ENST00000259818 7 3d EP300 P1452 1452 199 3biy_A(0.0159) Hotspot-linked F:1|L:2 0.0159 3 2 hnsc:1|cscc:2 ENST00000263253 7 3d EP300 Q1455 1455 199 3biy_A(0.0159) Hotspot-linked R:1|H:1 0.0159 2 1 blca:2 ENST00000263253 7 3d EP300 S1642 1642 199 3biy_A(0.0159) Hotspot-linked F:1 0.0159 1 1 skcm:1 ENST00000263253 7 3d ITGA4 V459 459 201 4irz_A(0.0159) Cluster-exclusive D:1 0.0159 1 1 brca:1 ENST00000397033 2 3d MGAT1 A186 186 202 1foa_A(0.016) Cluster-exclusive E:1|V:1 0.016 2 2 stad:1|lusc:1 ENST00000307826 4 3d MGAT1 R187 187 202 1foa_A(0.016) Cluster-exclusive C:1|L:1 0.016 2 2 ov:1|lihc:1 ENST00000307826 4 3d MGAT1 R190 190 202 1foa_A(0.016) Cluster-exclusive S:1 0.016 1 1 kirp:1 ENST00000307826 4 3d MGAT1 A192 192 202 1foa_A(0.016) Cluster-exclusive V:1 0.016 1 1 ucec:1 ENST00000307826 4 3d MGAT1 W276 276 202 1foa_A(0.016) Cluster-exclusive C:1 0.016 1 1 luad:1 ENST00000307826 4 3d MGAT1 P281 281 202 1foa_A(0.016) Cluster-exclusive L:1 0.016 1 1 cscc:1 ENST00000307826 4 3d MGAT1 W283 283 202 1foa_A(0.016) Cluster-exclusive R:1 0.016 1 1 cscc:1 ENST00000307826 4 3d EGFR R252 252 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked P:3|C:3|H:2 0.0161 8 3 stad:2|gbm:3|lgg:3 ENST00000275493 2 3d EGFR F254 254 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked I:1 0.0161 1 1 gbm:1 ENST00000275493 2 3d EGFR D256 256 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked G:1|Y:1 0.0161 2 2 gbm:1|lgg:1 ENST00000275493 2 3d EGFR K261 261 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked N:1 0.0161 1 1 ov:1 ENST00000275493 2 3d EGFR T263 263 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked P:2 0.0161 2 2 gbm:1|lgg:1 ENST00000275493 2 3d EGFR C264 264 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot-linked Y:1 0.0161 1 1 skcm:1 ENST00000275493 2 3d EGFR A289 289 203 3njp_B(0.0682);4kro_A(0.0767);3njp_A(0.0768);1yy9_A(0.072);1mox_A(0.019);1ivo_B(0.0161);1mox_B(0.0186);1nql_A(0.0726);3qwq_A(0.0769);1ivo_A(0.017) Hotspot D:3|T:6|V:17|I:1|N:1 0.0161 28 3 gbm:24|hnsc:1|lgg:3 ENST00000275493 2 3d CNOT9 L82 82 204 4ct6_B(0.0166);4ct7_B(0.0162);4cru_B(0.0272);2fv2_C(0.0167);4crv_B(0.0184);2fv2_D(0.0184);2fv2_A(0.0182);2fv2_B(0.0161) Hotspot-linked F:1 0.0161 1 1 ucec:1 ENST00000273064 6 3d CNOT9 S87 87 204 4ct6_B(0.0166);4ct7_B(0.0162);4cru_B(0.0272);2fv2_C(0.0167);4crv_B(0.0184);2fv2_D(0.0184);2fv2_A(0.0182);2fv2_B(0.0161) Hotspot P:3|C:3 0.0161 6 5 prad:1|stad:1|blca:1|skcm:2|lihc:1 ENST00000273064 6 3d CNOT9 N88 88 204 4ct6_B(0.0166);4ct7_B(0.0162);4cru_B(0.0272);2fv2_C(0.0167);4crv_B(0.0184);2fv2_D(0.0184);2fv2_A(0.0182);2fv2_B(0.0161) Hotspot-linked Y:1|K:1 0.0161 2 2 ov:1|skcm:1 ENST00000273064 6 3d CNOT9 P131 131 204 4ct6_B(0.0166);4ct7_B(0.0162);4cru_B(0.0272);2fv2_C(0.0167);4crv_B(0.0184);2fv2_D(0.0184);2fv2_A(0.0182);2fv2_B(0.0161) Hotspot S:1|L:13 0.0161 14 1 skcm:14 ENST00000273064 6 3d ACLY I6 6 205 3mwe_A(0.0174);3mwd_A(0.0162);3pff_A(0.0228) Cluster-exclusive V:1 0.0162 1 1 luad:1 ENST00000352035 2 3d ACLY S7 7 205 3mwe_A(0.0174);3mwd_A(0.0162);3pff_A(0.0228) Cluster-exclusive L:1 0.0162 1 1 skcm:1 ENST00000352035 2 3d ACLY E8 8 205 3mwe_A(0.0174);3mwd_A(0.0162);3pff_A(0.0228) Cluster-exclusive Q:1|K:1 0.0162 2 2 blca:1|cesc:1 ENST00000352035 2 3d ACLY T10 10 205 3mwe_A(0.0174);3mwd_A(0.0162);3pff_A(0.0228) Cluster-exclusive M:2 0.0162 2 2 coadread:1|esca:1 ENST00000352035 2 3d ACLY P239 239 205 3mwe_A(0.0174);3mwd_A(0.0162);3pff_A(0.0228) Cluster-exclusive L:1 0.0162 1 1 skcm:1 ENST00000352035 2 3d EEF1A1 T24 24 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive A:1 0.0162 1 1 lihc:1 ENST00000309268 6 3d EEF1A1 G25 25 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive C:1 0.0162 1 1 luad:1 ENST00000309268 6 3d EEF1A1 L27 27 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive V:1 0.0162 1 1 cesc:1 ENST00000309268 6 3d EEF1A1 I28 28 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive V:1 0.0162 1 1 lgg:1 ENST00000309268 6 3d EEF1A1 Y29 29 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive C:1 0.0162 1 1 hnsc:1 ENST00000309268 6 3d EEF1A1 I34 34 206 1ijf_A(0.0162);1ije_A(0.0173);1f60_A(0.0184);1g7c_A(0.0174);2b7b_A(0.0195);2b7c_A(0.0176) Cluster-exclusive M:1 0.0162 1 1 luad:1 ENST00000309268 6 3d PTPN11 L262 262 207 4h34_A(0.0163) Hotspot-linked F:1 0.0163 1 1 skcm:1 ENST00000351677 2 3d NOTCH1 A2019 2019 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive P:1 0.0164 1 1 luad:1 ENST00000277541 6 3d NOTCH1 D2020 2020 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive H:1 0.0164 1 1 lusc:1 ENST00000277541 6 3d NOTCH1 V2021 2021 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive I:1 0.0164 1 1 lymbc:1 ENST00000277541 6 3d NOTCH1 A2023 2023 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive T:1 0.0164 1 1 hnsc:1 ENST00000277541 6 3d NOTCH1 S2030 2030 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive P:1 0.0164 1 1 skcm:1 ENST00000277541 6 3d NOTCH1 L2047 2047 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive F:1 0.0164 1 1 hnsc:1 ENST00000277541 6 3d NOTCH1 G2051 2051 210 2qc9_B(0.0615);2f8y_B(0.0823);1ymp_A(0.0164);1yyh_B(0.0517);3nbn_B(0.0381);2he0_A(0.0568);2f8x_K(0.0648);2f8y_A(0.0734);3v79_K(0.0627);3nbn_E(0.0433);2qc9_A(0.0455) Cluster-exclusive W:1 0.0164 1 1 stad:1 ENST00000277541 6 3d SPOP R121 121 212 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked Q:3 0.0166 3 2 ucec:2|luad:1 ENST00000347630 2 3d C10ORF71 Q88 88 213 3bg9_A(0.0168) Cluster-exclusive R:1|K:1 0.0168 2 1 stad:2 ENST00000374144 3 3d C10ORF71 S93 93 213 3bg9_A(0.0168) Cluster-exclusive L:1 0.0168 1 1 stad:1 ENST00000374144 3 3d C10ORF71 W95 95 213 3bg9_A(0.0168) Cluster-exclusive L:1 0.0168 1 1 luad:1 ENST00000374144 3 3d C10ORF71 A96 96 213 3bg9_A(0.0168) Cluster-exclusive V:3 0.0168 3 3 stad:1|ucec:1|luad:1 ENST00000374144 3 3d C10ORF71 A97 97 213 3bg9_A(0.0168) Cluster-exclusive D:1 0.0168 1 1 luad:1 ENST00000374144 3 3d C10ORF71 Q123 123 213 3bg9_A(0.0168) Cluster-exclusive H:1 0.0168 1 1 luad:1 ENST00000374144 3 3d H2BC4 F71 71 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive L:1 0.0169 1 1 luad:1 ENST00000314332 5 3d H2BC4 E72 72 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive Q:2 0.0169 2 2 brca:1|blca:1 ENST00000314332 5 3d H2BC4 I74 74 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive M:1 0.0169 1 1 cesc:1 ENST00000314332 5 3d H2BC4 E77 77 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive K:2 0.0169 2 2 brca:1|cesc:1 ENST00000314332 5 3d H2BC4 A78 78 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive V:1 0.0169 1 1 coadread:1 ENST00000314332 5 3d H2BC4 S79 79 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive F:2 0.0169 2 2 brca:1|skcm:1 ENST00000314332 5 3d H2BC4 A98 98 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive V:1 0.0169 1 1 lymbc:1 ENST00000314332 5 3d H2BC4 L103 103 214 3wa9_D(0.0196);3c9k_B(0.0193);3lel_H(0.0169);2hio_B(0.023);4kha_A(0.0373);3w99_H(0.0228);2xql_B(0.0217);1tzy_B(0.0251);2aro_F(0.0239) Cluster-exclusive P:1 0.0169 1 1 brca:1 ENST00000314332 5 3d NFE2L2 D77 77 216 2flu_P(0.0229);4ifl_P(0.017) Hotspot-linked G:1|H:1 0.017 2 2 lusc:1|cesc:1 ENST00000397062 3 3d NFE2L2 E79 79 216 2flu_P(0.0229);4ifl_P(0.017) Hotspot Q:9|D:1|V:2|K:6 0.017 18 6 blca:3|hnsc:7|lihc:1|lusc:4|cesc:2|luad:1 ENST00000397062 3 3d NFE2L2 T80 80 216 2flu_P(0.0229);4ifl_P(0.017) Hotspot P:2|A:2|R:2|K:3 0.017 9 7 esca:1|hnsc:1|ucec:3|lihc:1|lusc:1|kirp:1|luad:1 ENST00000397062 3 3d NFE2L2 G81 81 216 2flu_P(0.0229);4ifl_P(0.017) Hotspot C:2|S:3|D:2|V:3 0.017 10 7 brca:1|hnsc:1|lihc:2|ucec:1|lusc:3|kirc:1|kirp:1 ENST00000397062 3 3d NFE2L2 E82 82 216 2flu_P(0.0229);4ifl_P(0.017) Hotspot A:2|Q:1|D:7|G:1 0.017 11 7 blca:1|lihc:3|ucec:2|cesc:1|kirc:1|luad:2|kirp:1 ENST00000397062 3 3d RHOA I23 23 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked R:1 0.0171 1 1 lymbc:1 ENST00000418115 1 3d FMNL3 R280 280 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive Q:1|L:1 0.0173 2 2 blca:1|cscc:1 ENST00000335154 5 3d FMNL3 G281 281 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive R:1 0.0173 1 1 kirc:1 ENST00000335154 5 3d FMNL3 G282 282 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive C:1 0.0173 1 1 ucec:1 ENST00000335154 5 3d FMNL3 E284 284 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive K:1 0.0173 1 1 coadread:1 ENST00000335154 5 3d FMNL3 L287 287 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive F:2 0.0173 2 1 skcm:2 ENST00000335154 5 3d FMNL3 A288 288 218 3ghg_A(0.0197);3ghg_J(0.0173) Cluster-exclusive T:1 0.0173 1 1 hnsc:1 ENST00000335154 5 3d CD300C S38 38 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive F:1 0.0177 1 1 skcm:1 ENST00000330793 1 3d TTK D566 566 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive G:1 0.0178 1 1 lusc:1 ENST00000369798 2 3d TTK E571 571 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive K:4 0.0178 4 4 coadread:1|hnsc:1|skcm:1|ucec:1 ENST00000369798 2 3d TTK A573 573 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive V:1 0.0178 1 1 coadread:1 ENST00000369798 2 3d TTK L575 575 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive F:1|W:1 0.0178 2 1 luad:2 ENST00000369798 2 3d TTK G666 666 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive R:1|E:1 0.0178 2 2 brca:1|gbm:1 ENST00000369798 2 3d TTK A668 668 223 3dbq_A(0.0224);4bi0_A(0.0203);4bi2_A(0.0187);3wyx_A(0.0209);4c4e_A(0.0251);4c4f_A(0.024);2x9e_A(0.0178);2zmd_A(0.0184) Cluster-exclusive E:1 0.0178 1 1 lgg:1 ENST00000369798 2 3d NEBL E417 417 224 2bb5_A(0.0178) Cluster-exclusive K:3 0.0178 3 1 skcm:3 ENST00000377122 4 3d NEBL I420 420 224 2bb5_A(0.0178) Cluster-exclusive T:1 0.0178 1 1 luad:1 ENST00000377122 4 3d NEBL K421 421 224 2bb5_A(0.0178) Cluster-exclusive Q:1 0.0178 1 1 ucec:1 ENST00000377122 4 3d NEBL G422 422 224 2bb5_A(0.0178) Cluster-exclusive E:1 0.0178 1 1 cscc:1 ENST00000377122 4 3d NEBL K423 423 224 2bb5_A(0.0178) Cluster-exclusive N:1 0.0178 1 1 luad:1 ENST00000377122 4 3d NEBL G424 424 224 2bb5_A(0.0178) Cluster-exclusive E:1 0.0178 1 1 skcm:1 ENST00000377122 4 3d NEBL L427 427 224 2bb5_A(0.0178) Cluster-exclusive R:1 0.0178 1 1 stad:1 ENST00000377122 4 3d GCSH R51 51 227 2edg_A(0.0337);3klr_A(0.0181) Cluster-exclusive C:1|H:1 0.0181 2 2 cll:1|stad:1 ENST00000315467 3 3d GCSH K52 52 227 2edg_A(0.0337);3klr_A(0.0181) Cluster-exclusive N:1 0.0181 1 1 stad:1 ENST00000315467 3 3d GCSH H57 57 227 2edg_A(0.0337);3klr_A(0.0181) Cluster-exclusive Q:1 0.0181 1 1 hnsc:1 ENST00000315467 3 3d GCSH E58 58 227 2edg_A(0.0337);3klr_A(0.0181) Cluster-exclusive K:2 0.0181 2 1 ucec:2 ENST00000315467 3 3d GCSH W59 59 227 2edg_A(0.0337);3klr_A(0.0181) Cluster-exclusive L:1 0.0181 1 1 lusc:1 ENST00000315467 3 3d H2BC13 I74 74 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive M:1 0.0182 1 1 cesc:1 ENST00000377401 2 3d H2BC13 A78 78 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive D:1 0.0182 1 1 ucec:1 ENST00000377401 2 3d H2BC13 I90 90 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive T:1 0.0182 1 1 hnsc:1 ENST00000377401 2 3d H2BC13 T91 91 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive I:1 0.0182 1 1 stad:1 ENST00000377401 2 3d H2BC13 R93 93 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive T:1 0.0182 1 1 coadread:1 ENST00000377401 2 3d H2BC13 I95 95 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive M:1 0.0182 1 1 stad:1 ENST00000377401 2 3d H2BC13 R100 100 228 3lel_H(0.0271);3o62_D(0.0272);4kha_A(0.064);2cv5_H(0.0285);3b6f_D(0.0182);3b6g_D(0.0229);1kx5_D(0.0271);1aoi_D(0.0223);3w97_D(0.0315);1zbb_D(0.0272);3b6f_H(0.0203);3b6g_H(0.0212);3rek_H(0.0261);1p3b_D(0.0274);1p3i_D(0.0226);3tu4_D(0.03);1m19_D(0.0245) Cluster-exclusive C:1 0.0182 1 1 coadread:1 ENST00000377401 2 3d FLNA T938 938 229 1wdy_A(0.0227);4g8l_B(0.0184);4g8l_C(0.0363);4g8k_A(0.0207);4g8l_A(0.0205);4g8k_B(0.019);4g8l_D(0.0206) Cluster-exclusive M:1 0.0184 1 1 hnsc:1 ENST00000369850 3 3d FLNA G946 946 229 1wdy_A(0.0227);4g8l_B(0.0184);4g8l_C(0.0363);4g8k_A(0.0207);4g8l_A(0.0205);4g8k_B(0.019);4g8l_D(0.0206) Cluster-exclusive C:1 0.0184 1 1 luad:1 ENST00000369850 3 3d FLNA V947 947 229 1wdy_A(0.0227);4g8l_B(0.0184);4g8l_C(0.0363);4g8k_A(0.0207);4g8l_A(0.0205);4g8k_B(0.019);4g8l_D(0.0206) Cluster-exclusive I:1 0.0184 1 1 coadread:1 ENST00000369850 3 3d FLNA T950 950 229 1wdy_A(0.0227);4g8l_B(0.0184);4g8l_C(0.0363);4g8k_A(0.0207);4g8l_A(0.0205);4g8k_B(0.019);4g8l_D(0.0206) Cluster-exclusive P:1 0.0184 1 1 luad:1 ENST00000369850 3 3d FLNA D954 954 229 1wdy_A(0.0227);4g8l_B(0.0184);4g8l_C(0.0363);4g8k_A(0.0207);4g8l_A(0.0205);4g8k_B(0.019);4g8l_D(0.0206) Cluster-exclusive Y:1 0.0184 1 1 luad:1 ENST00000369850 3 3d MNDA K6 6 233 2dbg_A(0.019) Cluster-exclusive N:1 0.019 1 1 brca:1 ENST00000368141 4 3d MNDA K7 7 233 2dbg_A(0.019) Cluster-exclusive T:1|N:1 0.019 2 1 coadread:2 ENST00000368141 4 3d MNDA L9 9 233 2dbg_A(0.019) Cluster-exclusive F:2|I:1 0.019 3 3 coadread:1|skcm:1|cscc:1 ENST00000368141 4 3d MNDA K12 12 233 2dbg_A(0.019) Cluster-exclusive E:1 0.019 1 1 coadread:1 ENST00000368141 4 3d MNDA G13 13 233 2dbg_A(0.019) Cluster-exclusive E:1 0.019 1 1 skcm:1 ENST00000368141 4 3d MNDA F14 14 233 2dbg_A(0.019) Cluster-exclusive L:1 0.019 1 1 coadread:1 ENST00000368141 4 3d MNDA E15 15 233 2dbg_A(0.019) Cluster-exclusive D:1 0.019 1 1 lihc:1 ENST00000368141 4 3d MNDA D50 50 233 2dbg_A(0.019) Cluster-exclusive A:1|Y:1 0.019 2 2 paad:1|hnsc:1 ENST00000368141 4 3d MNDA M52 52 233 2dbg_A(0.019) Cluster-exclusive L:1 0.019 1 1 luad:1 ENST00000368141 4 3d MNDA E53 53 233 2dbg_A(0.019) Cluster-exclusive K:1 0.019 1 1 skcm:1 ENST00000368141 4 3d MNDA L62 62 233 2dbg_A(0.019) Cluster-exclusive P:1 0.019 1 1 prad:1 ENST00000368141 4 3d MNDA L65 65 233 2dbg_A(0.019) Cluster-exclusive Q:1|R:1 0.019 2 2 ov:1|cscc:1 ENST00000368141 4 3d CREBBP S1778 1778 234 2ka6_A(0.0518);1f81_A(0.0584);2k8f_A(0.019) Cluster-exclusive L:1 0.019 1 1 skcm:1 ENST00000262367 5 3d CREBBP A1782 1782 234 2ka6_A(0.0518);1f81_A(0.0584);2k8f_A(0.019) Cluster-exclusive T:2 0.019 2 2 coadread:1|ucec:1 ENST00000262367 5 3d CREBBP R1786 1786 234 2ka6_A(0.0518);1f81_A(0.0584);2k8f_A(0.019) Cluster-exclusive C:1 0.019 1 1 coadread:1 ENST00000262367 5 3d CREBBP C1795 1795 234 2ka6_A(0.0518);1f81_A(0.0584);2k8f_A(0.019) Cluster-exclusive R:1 0.019 1 1 pias:1 ENST00000262367 5 3d CREBBP V1802 1802 234 2ka6_A(0.0518);1f81_A(0.0584);2k8f_A(0.019) Cluster-exclusive M:1 0.019 1 1 stad:1 ENST00000262367 5 3d PRPF31 R288 288 235 3siu_E(0.0191) Cluster-exclusive Q:1|L:1 0.0191 2 2 cll:1|cesc:1 ENST00000321030 4 3d PRPF31 R289 289 235 3siu_E(0.0191) Cluster-exclusive Q:1|W:1 0.0191 2 2 stad:1|lgg:1 ENST00000321030 4 3d PRPF31 R293 293 235 3siu_E(0.0191) Cluster-exclusive W:1 0.0191 1 1 esca:1 ENST00000321030 4 3d PRPF31 V295 295 235 3siu_E(0.0191) Cluster-exclusive M:1 0.0191 1 1 coadread:1 ENST00000321030 4 3d PRPF31 A297 297 235 3siu_E(0.0191) Cluster-exclusive T:1 0.0191 1 1 coadread:1 ENST00000321030 4 3d PRPF31 K298 298 235 3siu_E(0.0191) Cluster-exclusive R:1 0.0191 1 1 cscc:1 ENST00000321030 4 3d NRAS A83 83 238 2cl6_X(0.0193) Hotspot-linked V:1 0.0193 1 1 skcm:1 ENST00000369535 4 3d IQUB V133 133 240 2daf_A(0.0194) Cluster-exclusive I:1 0.0194 1 1 skcm:1 ENST00000324698 6 3d IQUB V135 135 240 2daf_A(0.0194) Cluster-exclusive F:1|L:1 0.0194 2 2 brca:1|lusc:1 ENST00000324698 6 3d IQUB V136 136 240 2daf_A(0.0194) Cluster-exclusive L:2 0.0194 2 2 skcm:1|luad:1 ENST00000324698 6 3d IQUB E143 143 240 2daf_A(0.0194) Cluster-exclusive K:2 0.0194 2 2 skcm:1|cscc:1 ENST00000324698 6 3d IQUB V145 145 240 2daf_A(0.0194) Cluster-exclusive L:1 0.0194 1 1 lusm:1 ENST00000324698 6 3d IQUB E201 201 240 2daf_A(0.0194) Cluster-exclusive K:1 0.0194 1 1 cscc:1 ENST00000324698 6 3d IQUB G141 141 241 2daf_A(0.0194) Cluster-exclusive A:1 0.0194 1 1 hnsc:1 ENST00000324698 6 3d IQUB D220 220 241 2daf_A(0.0194) Cluster-exclusive H:1 0.0194 1 1 hnsc:1 ENST00000324698 6 3d ZNF777 R541 541 243 1xwd_C(0.0195);4ay9_X(0.0246) Cluster-exclusive C:1 0.0195 1 1 paad:1 ENST00000247930 4 3d ZNF777 G542 542 243 1xwd_C(0.0195);4ay9_X(0.0246) Cluster-exclusive S:1 0.0195 1 1 brca:1 ENST00000247930 4 3d ZNF777 R566 566 243 1xwd_C(0.0195);4ay9_X(0.0246) Cluster-exclusive H:2 0.0195 2 1 coadread:2 ENST00000247930 4 3d ZNF777 H568 568 243 1xwd_C(0.0195);4ay9_X(0.0246) Cluster-exclusive Y:1 0.0195 1 1 stad:1 ENST00000247930 4 3d ZNF777 R584 584 243 1xwd_C(0.0195);4ay9_X(0.0246) Cluster-exclusive W:2 0.0195 2 2 blca:1|skcm:1 ENST00000247930 4 3d CNTN2 G391 391 245 1cs6_A(0.0196) Cluster-exclusive S:1 0.0196 1 1 ucec:1 ENST00000331830 4 3d CNTN2 A406 406 245 1cs6_A(0.0196) Cluster-exclusive V:1 0.0196 1 1 ucs:1 ENST00000331830 4 3d CNTN2 A408 408 245 1cs6_A(0.0196) Cluster-exclusive T:1 0.0196 1 1 stad:1 ENST00000331830 4 3d CNTN2 E409 409 245 1cs6_A(0.0196) Cluster-exclusive K:1 0.0196 1 1 skcm:1 ENST00000331830 4 3d THBS2 A685 685 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive E:1|V:1 0.0205 2 2 blca:1|luad:1 ENST00000366787 3 3d THBS2 E693 693 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive K:1 0.0205 1 1 lusm:1 ENST00000366787 3 3d THBS2 D696 696 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive N:2 0.0205 2 1 skcm:2 ENST00000366787 3 3d THBS2 D698 698 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive E:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 G699 699 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive A:1|C:1|V:1 0.0205 3 1 luad:3 ENST00000366787 3 3d THBS2 W700 700 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive R:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 D718 718 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive N:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 S726 726 246 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive Y:1 0.0205 1 1 coadread:1 ENST00000366787 3 3d THBS2 C680 680 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive Y:1 0.0205 1 1 nbl:1 ENST00000366787 3 3d THBS2 G683 683 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive R:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 D687 687 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive N:1 0.0205 1 1 coadread:1 ENST00000366787 3 3d THBS2 G692 692 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive W:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 L723 723 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive V:2 0.0205 2 2 blca:1|luad:1 ENST00000366787 3 3d THBS2 D1164 1164 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive Y:1 0.0205 1 1 gbm:1 ENST00000366787 3 3d NUF2 R19 19 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive C:1|H:1 0.021 2 2 coadread:1|ucec:1 ENST00000271452 3 3d NUF2 L23 23 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive F:1 0.021 1 1 luad:1 ENST00000271452 3 3d NUF2 D27 27 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive N:1 0.021 1 1 lusc:1 ENST00000271452 3 3d NUF2 G28 28 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive S:1|C:1 0.021 2 2 lusc:1|luad:1 ENST00000271452 3 3d NUF2 M47 47 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive I:1 0.021 1 1 kirc:1 ENST00000271452 3 3d NUF2 R51 51 254 2ve7_D(0.0257);3iz0_F(0.021);2ve7_C(0.0249);3iz0_D(0.0219) Cluster-exclusive S:1 0.021 1 1 ucec:1 ENST00000271452 3 3d TDRD7 V237 237 255 2ly2_A(0.0211);2ly1_A(0.0224) Cluster-exclusive I:1 0.0211 1 1 lusc:1 ENST00000355295 4 3d TDRD7 Q238 238 255 2ly2_A(0.0211);2ly1_A(0.0224) Cluster-exclusive R:1 0.0211 1 1 coadread:1 ENST00000355295 4 3d TDRD7 N239 239 255 2ly2_A(0.0211);2ly1_A(0.0224) Cluster-exclusive H:1 0.0211 1 1 ucec:1 ENST00000355295 4 3d TDRD7 R240 240 255 2ly2_A(0.0211);2ly1_A(0.0224) Cluster-exclusive H:1 0.0211 1 1 coadread:1 ENST00000355295 4 3d TDRD7 W280 280 255 2ly2_A(0.0211);2ly1_A(0.0224) Cluster-exclusive C:1 0.0211 1 1 luad:1 ENST00000355295 4 3d CFH E23 23 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive K:1 0.0214 1 1 skcm:1 ENST00000367429 4 3d CFH L24 24 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive R:1 0.0214 1 1 esca:1 ENST00000367429 4 3d CFH P25 25 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive H:1 0.0214 1 1 paad:1 ENST00000367429 4 3d CFH P26 26 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive S:1 0.0214 1 1 skcm:1 ENST00000367429 4 3d CFH Q47 47 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive H:2 0.0214 2 2 coadread:1|stad:1 ENST00000367429 4 3d CFH A48 48 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive T:1 0.0214 1 1 skcm:1 ENST00000367429 4 3d CFH V65 65 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive I:1 0.0214 1 1 kirc:1 ENST00000367429 4 3d CFH G69 69 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive E:1|V:1 0.0214 2 2 hnsc:1|cscc:1 ENST00000367429 4 3d CFH E70 70 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive D:1 0.0214 1 1 stad:1 ENST00000367429 4 3d CFH W71 71 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive C:1 0.0214 1 1 luad:1 ENST00000367429 4 3d CFH V72 72 256 2wii_C(0.0214);2rlp_A(0.0591) Cluster-exclusive I:1 0.0214 1 1 cll:1 ENST00000367429 4 3d PCDHB13 H512 512 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive N:1 0.0216 1 1 brca:1 ENST00000341948 4 3d PCDHB13 A515 515 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive G:1 0.0216 1 1 lihc:1 ENST00000341948 4 3d PCDHB13 L519 519 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive Q:1 0.0216 1 1 luad:1 ENST00000341948 4 3d PCDHB13 R530 530 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive C:1|H:3|L:1 0.0216 5 5 acc:1|coadread:1|esca:1|ov:1|luad:1 ENST00000341948 4 3d PCDHB13 S534 534 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive T:1 0.0216 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 D535 535 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive E:1 0.0216 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 G537 537 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive V:1 0.0216 1 1 paad:1 ENST00000341948 4 3d PCDHB13 S538 538 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive F:1 0.0216 1 1 skcm:1 ENST00000341948 4 3d PCDHB13 P539 539 257 4ly9_B(0.0216);4ly9_A(0.0229) Cluster-exclusive L:1 0.0216 1 1 luad:1 ENST00000341948 4 3d ZNF443 C314 314 258 2hod_B(0.0236);1fzc_B(0.0216);2hpc_K(0.0293);2hod_K(0.0276);1n86_B(0.0241);2hpc_B(0.0256);2hod_E(0.0281);2hpc_E(0.0272) Cluster-exclusive Y:1 0.0216 1 1 brca:1 ENST00000301547 5 3d ZNF443 G315 315 258 2hod_B(0.0236);1fzc_B(0.0216);2hpc_K(0.0293);2hod_K(0.0276);1n86_B(0.0241);2hpc_B(0.0256);2hod_E(0.0281);2hpc_E(0.0272) Cluster-exclusive W:1 0.0216 1 1 luad:1 ENST00000301547 5 3d ZNF443 S319 319 258 2hod_B(0.0236);1fzc_B(0.0216);2hpc_K(0.0293);2hod_K(0.0276);1n86_B(0.0241);2hpc_B(0.0256);2hod_E(0.0281);2hpc_E(0.0272) Cluster-exclusive R:1 0.0216 1 1 ucs:1 ENST00000301547 5 3d ZNF443 S321 321 258 2hod_B(0.0236);1fzc_B(0.0216);2hpc_K(0.0293);2hod_K(0.0276);1n86_B(0.0241);2hpc_B(0.0256);2hod_E(0.0281);2hpc_E(0.0272) Cluster-exclusive F:1 0.0216 1 1 cesc:1 ENST00000301547 5 3d ZNF443 S323 323 258 2hod_B(0.0236);1fzc_B(0.0216);2hpc_K(0.0293);2hod_K(0.0276);1n86_B(0.0241);2hpc_B(0.0256);2hod_E(0.0281);2hpc_E(0.0272) Cluster-exclusive F:2 0.0216 2 1 skcm:2 ENST00000301547 5 3d CLTCL1 V478 478 259 3iyv_A(0.0216);1xi5_A(0.0245);1xi4_A(0.0243) Cluster-exclusive A:1 0.0216 1 1 lihc:1 ENST00000427926 1 3d CLTCL1 L480 480 259 3iyv_A(0.0216);1xi5_A(0.0245);1xi4_A(0.0243) Cluster-exclusive F:1 0.0216 1 1 prad:1 ENST00000427926 1 3d CLTCL1 R481 481 259 3iyv_A(0.0216);1xi5_A(0.0245);1xi4_A(0.0243) Cluster-exclusive P:1|W:2 0.0216 3 3 paad:1|coadread:1|lihc:1 ENST00000427926 1 3d PTPN1 L83 83 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive V:1 0.0217 1 1 blca:1 ENST00000371621 3 3d PTPN1 A217 217 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive T:1 0.0217 1 1 coadread:1 ENST00000371621 3 3d PTPN1 I219 219 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive T:1 0.0217 1 1 ucec:1 ENST00000371621 3 3d PTPN1 G220 220 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive D:1 0.0217 1 1 luad:1 ENST00000371621 3 3d PTPN1 R257 257 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive W:1 0.0217 1 1 skcm:1 ENST00000371621 3 3d PTPN1 M258 258 261 1onz_A(0.0299);1t4j_A(0.0288);2hnq_A(0.0297);4qah_A(0.0236);2hnp_A(0.0277);1ony_A(0.0309);1wax_A(0.0306);1oeo_X(0.0313);1jf7_A(0.0299);3eax_A(0.0308);1q1m_A(0.025);1nwl_A(0.0256);1no6_A(0.0318);1ptu_A(0.0276);1ptv_A(0.0246);1ph0_A(0.0298);3eb1_A(0.031);4qbe_A(0.0217);3eu0_A(0.0264);1oet_A(0.0297);2bgd_A(0.024);1kak_A(0.0283);2cm7_A(0.0295);1aax_A(0.0234);2cm3_B(0.0265);1nl9_A(0.0324);1t49_A(0.0276);3qkp_A(0.0279);1nny_A(0.0311);1pyn_A(0.0264);3qkq_A(0.0256);1oeu_A(0.0326);1bzh_A(0.0302);3d9c_A(0.0307);2cma_A(0.0259);1nz7_A(0.0312) Cluster-exclusive I:1 0.0217 1 1 skcm:1 ENST00000371621 3 3d VHL S80 80 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked R:2|I:1 0.0219 3 2 paad:1|kirc:2 ENST00000256474 2 3d VHL R82 82 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Cluster-exclusive P:1 0.0219 1 1 kirc:1 ENST00000256474 2 3d VHL R120 120 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Cluster-exclusive G:1 0.0219 1 1 kirc:1 ENST00000256474 2 3d VHL D121 121 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Cluster-exclusive Y:3 0.0219 3 1 kirc:3 ENST00000256474 2 3d VHL G127 127 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Cluster-exclusive V:2 0.0219 2 2 coadread:1|stad:1 ENST00000256474 2 3d VHL L128 128 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked H:3 0.0219 3 2 kirc:2|luad:1 ENST00000256474 2 3d VHL L129 129 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked P:1 0.0219 1 1 kirc:1 ENST00000256474 2 3d VHL V130 130 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked D:1|F:1 0.0219 2 1 kirc:2 ENST00000256474 2 3d VHL T133 133 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Cluster-exclusive P:1 0.0219 1 1 kirc:1 ENST00000256474 2 3d VHL I151 151 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked T:2|F:1|N:1 0.0219 4 1 kirc:4 ENST00000256474 2 3d VHL L153 153 263 4awj_I(0.0335);1vcb_F(0.0274);1vcb_C(0.0333);1vcb_I(0.029);4bkt_C(0.0345);4bks_C(0.0323);4bkt_F(0.0305);4awj_F(0.0273);4bks_F(0.0294);4awj_C(0.028);3ztd_L(0.0327);3zrc_I(0.0333);3zrf_F(0.0302);3ztc_I(0.029);3ztd_I(0.0314);3zrf_I(0.0308);3zrc_L(0.0301);3ztc_L(0.0287);4ajy_V(0.0343);1vcb_L(0.0323);1lm8_V(0.0236);4wqo_A(0.0287);3ztc_F(0.0232);4b95_F(0.0268);3ztd_F(0.0255);3zrc_F(0.0345);3zrf_C(0.0289);4b95_L(0.0417);3ztc_C(0.0229);3zrc_C(0.0219);4b95_I(0.0328);3ztd_C(0.0285);4b9k_L(0.0305);3zun_C(0.0233);4bkt_I(0.0361);3zun_F(0.0313);4bks_I(0.0363);1lqb_C(0.0267);4b95_C(0.0292);4b9k_I(0.0311);3zun_L(0.0343);4b9k_C(0.0295);4b9k_F(0.031);3zun_I(0.0374) Hotspot-linked P:2 0.0219 2 1 kirc:2 ENST00000256474 2 3d GOLGA2 L29 29 264 1qub_A(0.022) Cluster-exclusive F:1 0.022 1 1 luad:1 ENST00000421699 2 3d GOLGA2 A44 44 264 1qub_A(0.022) Cluster-exclusive V:1 0.022 1 1 gbm:1 ENST00000421699 2 3d GOLGA2 K46 46 264 1qub_A(0.022) Cluster-exclusive R:1 0.022 1 1 stad:1 ENST00000421699 2 3d GOLGA2 K47 47 264 1qub_A(0.022) Cluster-exclusive R:1 0.022 1 1 coadread:1 ENST00000421699 2 3d GOLGA2 K48 48 264 1qub_A(0.022) Cluster-exclusive N:2 0.022 2 1 luad:2 ENST00000421699 2 3d PTEN V45 45 266 1d5r_A(0.0223) Cluster-exclusive E:1 0.0223 1 1 gbm:1 ENST00000371953 3 3d CYP2A6 R148 148 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive H:1 0.0223 1 1 luad:1 ENST00000301141 5 3d CYP2A6 I149 149 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive T:1 0.0223 1 1 stad:1 ENST00000301141 5 3d CYP2A6 E152 152 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive K:2 0.0223 2 2 hnsc:1|cscc:1 ENST00000301141 5 3d CYP2A6 A153 153 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive V:1 0.0223 1 1 lusc:1 ENST00000301141 5 3d CYP2A6 F155 155 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive L:1 0.0223 1 1 stad:1 ENST00000301141 5 3d CYP2A6 R176 176 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive H:2 0.0223 2 2 lusc:1|luad:1 ENST00000301141 5 3d CYP2A6 F452 452 267 3t3q_B(0.0492);3t3q_C(0.0463);3t3s_A(0.0301);2pg6_A(0.0451);3t3q_A(0.0469);3t3q_D(0.0479);4ejg_H(0.0223);4ejg_G(0.0235);4ejg_A(0.0334);4ejg_D(0.0283);4eji_A(0.0329);2fdy_D(0.0507);2fdy_B(0.0504);2fdw_D(0.0494);2fdy_C(0.0504);2fdw_B(0.0476);2fdu_D(0.0486);2fdw_C(0.048);2fdy_A(0.0426);2fdu_B(0.0564);2fdu_C(0.0493);2fdw_A(0.0522);2fdu_A(0.0467);2pg6_B(0.0476);2pg6_C(0.0436);1z11_A(0.053);4rui_F(0.0473);4rui_E(0.0456);3ebs_A(0.0451);3ebs_B(0.042);3ebs_C(0.0434);1z11_D(0.0536);1z11_C(0.0565);1z11_B(0.0517);3ebs_D(0.0448);4rui_A(0.0483);4rui_D(0.0491);4rui_C(0.0468);3t3r_A(0.0473);3t3r_B(0.0439);2pg5_A(0.0509);2pg5_B(0.0509);4ejh_H(0.0296);3t3r_C(0.0476);3t3r_D(0.0478);4ejj_C(0.0455);4ejj_B(0.044);4ejh_G(0.0304);4ejh_A(0.0366);4ejj_A(0.0449);2fdv_C(0.0498);2fdv_D(0.0453);2fdv_A(0.0461);2fdv_B(0.0489);2pg5_C(0.0512);2pg7_A(0.0455);2pg7_B(0.0422);1z10_B(0.0532);1z10_A(0.0491);1z10_D(0.0529);1z10_C(0.0523);2p85_A(0.0411) Cluster-exclusive L:1 0.0223 1 1 ucec:1 ENST00000301141 5 3d NMT1 F400 400 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive L:1 0.0228 1 1 lihc:1 ENST00000258960 2 3d NMT1 S421 421 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive F:1 0.0228 1 1 skcm:1 ENST00000258960 2 3d NMT1 F422 422 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive L:1 0.0228 1 1 luad:1 ENST00000258960 2 3d NMT1 A438 438 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive T:1 0.0228 1 1 stad:1 ENST00000258960 2 3d NMT1 L441 441 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive F:1 0.0228 1 1 skcm:1 ENST00000258960 2 3d NMT1 F450 450 269 3iu1_A(0.0345);3iwe_A(0.0293);3iwe_B(0.0284);3jtk_A(0.0346);1rxt_A(0.0228);1rxt_B(0.0233);1rxt_C(0.0237);1rxt_D(0.0232);4c2y_A(0.0345) Cluster-exclusive L:1 0.0228 1 1 skcm:1 ENST00000258960 2 3d LRRC3B K36 36 270 2e8n_A(0.0229) Cluster-exclusive M:1 0.0229 1 1 luad:1 ENST00000396641 2 3d LRRC3B G37 37 270 2e8n_A(0.0229) Cluster-exclusive V:1 0.0229 1 1 luad:1 ENST00000396641 2 3d LRRC3B L39 39 270 2e8n_A(0.0229) Cluster-exclusive F:2 0.0229 2 2 skcm:1|cscc:1 ENST00000396641 2 3d LRRC3B C40 40 270 2e8n_A(0.0229) Cluster-exclusive W:1 0.0229 1 1 stad:1 ENST00000396641 2 3d LRRC3B S43 43 270 2e8n_A(0.0229) Cluster-exclusive A:1 0.0229 1 1 lihc:1 ENST00000396641 2 3d LRRC3B P63 63 270 2e8n_A(0.0229) Cluster-exclusive S:2 0.0229 2 1 skcm:2 ENST00000396641 2 3d LRRC3B P64 64 270 2e8n_A(0.0229) Cluster-exclusive H:1 0.0229 1 1 lusc:1 ENST00000396641 2 3d LRRC3B E65 65 270 2e8n_A(0.0229) Cluster-exclusive K:1 0.0229 1 1 skcm:1 ENST00000396641 2 3d LRRC3B L68 68 270 2e8n_A(0.0229) Cluster-exclusive V:2 0.0229 2 2 stad:1|esca:1 ENST00000396641 2 3d LRRC3B S96 96 270 2e8n_A(0.0229) Cluster-exclusive Y:1 0.0229 1 1 luad:1 ENST00000396641 2 3d GRB2 F95 95 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive V:1 0.023 1 1 brca:1 ENST00000316804 5 3d GRB2 R112 112 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive Q:1 0.023 1 1 skcm:1 ENST00000316804 5 3d GRB2 D113 113 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive H:1 0.023 1 1 all:1 ENST00000316804 5 3d GRB2 G116 116 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive R:1|W:1 0.023 2 2 coadread:1|lihc:1 ENST00000316804 5 3d GRB2 K117 117 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive R:1 0.023 1 1 ucec:1 ENST00000316804 5 3d GRB2 Y118 118 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive S:1 0.023 1 1 mmyl:1 ENST00000316804 5 3d GRB2 S127 127 271 1gri_A(0.023);1x0n_A(0.0595);1ghu_A(0.0584);1gri_B(0.0243) Cluster-exclusive Y:1 0.023 1 1 coadread:1 ENST00000316804 5 3d USH1C E461 461 272 1v6b_A(0.023) Cluster-exclusive Q:2 0.023 2 2 brca:1|luad:1 ENST00000318024 4 3d USH1C A525 525 272 1v6b_A(0.023) Cluster-exclusive V:1 0.023 1 1 coadread:1 ENST00000318024 4 3d USH1C W526 526 272 1v6b_A(0.023) Cluster-exclusive R:1 0.023 1 1 prad:1 ENST00000318024 4 3d USH1C Q528 528 272 1v6b_A(0.023) Cluster-exclusive R:1 0.023 1 1 gbm:1 ENST00000318024 4 3d USH1C G530 530 272 1v6b_A(0.023) Cluster-exclusive W:1 0.023 1 1 luad:1 ENST00000318024 4 3d USH1C I533 533 272 1v6b_A(0.023) Cluster-exclusive S:1 0.023 1 1 brca:1 ENST00000318024 4 3d BTNL3 P24 24 273 1sn6_A(0.0511);2qyp_B(0.0232);2qyp_A(0.023);1m12_A(0.0919);2gtg_A(0.0693) Cluster-exclusive Q:1 0.023 1 1 lusc:1 ENST00000342868 6 3d BTNL3 Q29 29 273 1sn6_A(0.0511);2qyp_B(0.0232);2qyp_A(0.023);1m12_A(0.0919);2gtg_A(0.0693) Cluster-exclusive K:1 0.023 1 1 luad:1 ENST00000342868 6 3d BTNL3 L31 31 273 1sn6_A(0.0511);2qyp_B(0.0232);2qyp_A(0.023);1m12_A(0.0919);2gtg_A(0.0693) Cluster-exclusive F:2 0.023 2 2 lusc:1|luad:1 ENST00000342868 6 3d BTNL3 G33 33 273 1sn6_A(0.0511);2qyp_B(0.0232);2qyp_A(0.023);1m12_A(0.0919);2gtg_A(0.0693) Cluster-exclusive R:1 0.023 1 1 luad:1 ENST00000342868 6 3d TUBB2B G148 148 274 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4f61_H(0.0322);4i55_B(0.0524);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3ut5_B(0.0389);4drx_B(0.0295);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);2xrp_A(0.0292);2hxf_B(0.0261);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);2hxh_B(0.029);3ryc_B(0.0392);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryh_B(0.0352);3ryf_D(0.0302);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive S:1 0.0231 1 1 ucec:1 ENST00000259818 7 3d PCDHB13 E544 544 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive Q:1|K:1 0.0232 2 2 blca:1|skcm:1 ENST00000341948 4 3d PCDHB13 R548 548 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive H:1 0.0232 1 1 gbm:1 ENST00000341948 4 3d UNC5C G354 354 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive R:1|S:1 0.0233 2 2 skcm:1|ucec:1 ENST00000453304 1 3d UNC5C L355 355 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive I:1 0.0233 1 1 luad:1 ENST00000453304 1 3d UNC5C V356 356 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive I:1 0.0233 1 1 ov:1 ENST00000453304 1 3d UNC5C L357 357 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive F:1|W:1 0.0233 2 2 ucec:1|luad:1 ENST00000453304 1 3d UNC5C D364 364 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive V:1|Y:1 0.0233 2 2 coadread:1|luad:1 ENST00000453304 1 3d UNC5C L435 435 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive M:1 0.0233 1 1 esca:1 ENST00000453304 1 3d UNC5C N467 467 276 1z3u_A(0.0238);1z3s_A(0.0238);4jzc_A(0.0233) Cluster-exclusive T:1|K:1 0.0233 2 2 esca:1|hnsc:1 ENST00000453304 1 3d SRM K134 134 280 2o06_A(0.0238);3rw9_B(0.0251);2o05_B(0.0245);2o05_A(0.0258);2o07_B(0.0343);2o07_A(0.0286);2o06_B(0.0264);3rw9_A(0.0296);2o0l_B(0.0275);2o0l_A(0.0245) Cluster-exclusive N:1 0.0238 1 1 blca:1 ENST00000376957 2 3d SRM P138 138 280 2o06_A(0.0238);3rw9_B(0.0251);2o05_B(0.0245);2o05_A(0.0258);2o07_B(0.0343);2o07_A(0.0286);2o06_B(0.0264);3rw9_A(0.0296);2o0l_B(0.0275);2o0l_A(0.0245) Cluster-exclusive S:1 0.0238 1 1 stad:1 ENST00000376957 2 3d SRM A141 141 280 2o06_A(0.0238);3rw9_B(0.0251);2o05_B(0.0245);2o05_A(0.0258);2o07_B(0.0343);2o07_A(0.0286);2o06_B(0.0264);3rw9_A(0.0296);2o0l_B(0.0275);2o0l_A(0.0245) Cluster-exclusive V:2 0.0238 2 2 brca:1|cscc:1 ENST00000376957 2 3d SRM G143 143 280 2o06_A(0.0238);3rw9_B(0.0251);2o05_B(0.0245);2o05_A(0.0258);2o07_B(0.0343);2o07_A(0.0286);2o06_B(0.0264);3rw9_A(0.0296);2o0l_B(0.0275);2o0l_A(0.0245) Cluster-exclusive S:1 0.0238 1 1 lihc:1 ENST00000376957 2 3d SRM S145 145 280 2o06_A(0.0238);3rw9_B(0.0251);2o05_B(0.0245);2o05_A(0.0258);2o07_B(0.0343);2o07_A(0.0286);2o06_B(0.0264);3rw9_A(0.0296);2o0l_B(0.0275);2o0l_A(0.0245) Cluster-exclusive F:1 0.0238 1 1 cesc:1 ENST00000376957 2 3d STIM1 A79 79 282 2k60_A(0.0241) Cluster-exclusive T:1 0.0241 1 1 luad:1 ENST00000300737 4 3d PARP1 D72 72 283 2dmj_A(0.0242) Cluster-exclusive H:1 0.0242 1 1 blca:1 ENST00000366794 5 3d PARP1 L77 77 283 2dmj_A(0.0242) Cluster-exclusive I:1 0.0242 1 1 brca:1 ENST00000366794 5 3d PARP1 R78 78 283 2dmj_A(0.0242) Cluster-exclusive W:1 0.0242 1 1 paad:1 ENST00000366794 5 3d PARP1 W79 79 283 2dmj_A(0.0242) Cluster-exclusive L:1 0.0242 1 1 ucec:1 ENST00000366794 5 3d PARP1 D81 81 283 2dmj_A(0.0242) Cluster-exclusive G:1 0.0242 1 1 coadread:1 ENST00000366794 5 3d EGFR V769 769 285 2jiu_B(0.0245) Hotspot-linked L:1 0.0245 1 1 luad:1 ENST00000275493 2 3d EGFR R831 831 285 2jiu_B(0.0245) Hotspot-linked H:2 0.0245 2 2 coadread:1|luad:1 ENST00000275493 2 3d EGFR R832 832 285 2jiu_B(0.0245) Hotspot-linked C:1|H:1 0.0245 2 2 ucec:1|kirc:1 ENST00000275493 2 3d EGFR L833 833 285 2jiu_B(0.0245) Hotspot-linked F:1|V:1 0.0245 2 1 luad:2 ENST00000275493 2 3d EGFR L858 858 285 2jiu_B(0.0245) Hotspot R:30 0.0245 30 1 luad:30 ENST00000275493 2 3d EGFR L861 861 285 2jiu_B(0.0245) Hotspot Q:7 0.0245 7 2 lusc:2|luad:5 ENST00000275493 2 3d EGFR H893 893 285 2jiu_B(0.0245) Hotspot-linked Y:1 0.0245 1 1 coadread:1 ENST00000275493 2 3d KPNB1 L739 739 286 1ukl_A(0.0248) Cluster-exclusive V:1 0.0248 1 1 luad:1 ENST00000290158 4 3d KPNB1 Y769 769 286 1ukl_A(0.0248) Cluster-exclusive H:1 0.0248 1 1 ov:1 ENST00000290158 4 3d KPNB1 G771 771 286 1ukl_A(0.0248) Cluster-exclusive R:1|V:1 0.0248 2 2 paad:1|luad:1 ENST00000290158 4 3d KPNB1 V773 773 286 1ukl_A(0.0248) Cluster-exclusive A:1 0.0248 1 1 ucec:1 ENST00000290158 4 3d KPNB1 Q774 774 286 1ukl_A(0.0248) Cluster-exclusive P:1 0.0248 1 1 prad:1 ENST00000290158 4 3d KPNB1 R793 793 286 1ukl_A(0.0248) Cluster-exclusive K:1 0.0248 1 1 skcm:1 ENST00000290158 4 3d ANK1 A921 921 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive T:1 0.0256 1 1 skcm:1 ENST00000347528 4 3d ANK1 R922 922 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive W:1 0.0256 1 1 hgg:1 ENST00000347528 4 3d ANK1 G923 923 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive R:1|S:1 0.0256 2 2 skcm:1|lihc:1 ENST00000347528 4 3d ANK1 P940 940 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive Q:1 0.0256 1 1 luad:1 ENST00000347528 4 3d ANK1 R941 941 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive Q:1 0.0256 1 1 thca:1 ENST00000347528 4 3d ANK1 T942 942 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive M:1 0.0256 1 1 brca:1 ENST00000347528 4 3d ANK1 L1033 1033 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive I:1 0.0256 1 1 ucec:1 ENST00000347528 4 3d ANK1 G1035 1035 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive R:1 0.0256 1 1 brca:1 ENST00000347528 4 3d ANK1 M1036 1036 289 3f59_D(0.049);3ud2_C(0.0256);3ud2_A(0.0286);3ud2_B(0.0278);3f59_C(0.0482) Cluster-exclusive I:2 0.0256 2 1 skcm:2 ENST00000347528 4 3d ADAM19 G415 415 290 3n5n_Y(0.0283);3n5n_X(0.0257) Cluster-exclusive V:1 0.0257 1 1 ucec:1 ENST00000517905 1 3d ADAM19 R417 417 290 3n5n_Y(0.0283);3n5n_X(0.0257) Cluster-exclusive W:1 0.0257 1 1 stad:1 ENST00000517905 1 3d ADAM19 G420 420 290 3n5n_Y(0.0283);3n5n_X(0.0257) Cluster-exclusive W:1 0.0257 1 1 hnsc:1 ENST00000517905 1 3d ADAM19 N421 421 290 3n5n_Y(0.0283);3n5n_X(0.0257) Cluster-exclusive K:1 0.0257 1 1 luad:1 ENST00000517905 1 3d ADAM19 G422 422 290 3n5n_Y(0.0283);3n5n_X(0.0257) Cluster-exclusive R:2 0.0257 2 2 lusm:1|cscc:1 ENST00000517905 1 3d F11R S295 295 291 3tsz_B(0.0257) Cluster-exclusive L:1 0.0257 1 1 cscc:1 ENST00000368026 6 3d F11R S296 296 291 3tsz_B(0.0257) Cluster-exclusive L:1 0.0257 1 1 hnsc:1 ENST00000368026 6 3d F11R L298 298 291 3tsz_B(0.0257) Cluster-exclusive R:1 0.0257 1 1 luad:1 ENST00000368026 6 3d F11R V299 299 291 3tsz_B(0.0257) Cluster-exclusive G:1 0.0257 1 1 stad:1 ENST00000368026 6 3d GPT2 L122 122 292 3ihj_A(0.0258) Cluster-exclusive R:1 0.0258 1 1 stad:1 ENST00000340124 4 3d GPT2 A131 131 292 3ihj_A(0.0258) Cluster-exclusive S:1|D:1 0.0258 2 1 lihc:2 ENST00000340124 4 3d GPT2 K132 132 292 3ihj_A(0.0258) Cluster-exclusive N:1 0.0258 1 1 ucec:1 ENST00000340124 4 3d GPT2 K133 133 292 3ihj_A(0.0258) Cluster-exclusive Q:1 0.0258 1 1 coadread:1 ENST00000340124 4 3d GPT2 R134 134 292 3ihj_A(0.0258) Cluster-exclusive H:1 0.0258 1 1 ucec:1 ENST00000340124 4 3d GPT2 R136 136 292 3ihj_A(0.0258) Cluster-exclusive Q:1|L:1 0.0258 2 2 esca:1|hnsc:1 ENST00000340124 4 3d GPT2 P391 391 293 3ihj_A(0.0258) Cluster-exclusive S:1 0.0258 1 1 skcm:1 ENST00000340124 4 3d MAP2K1 R49 49 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot-linked H:1 0.0261 1 1 coadread:1 ENST00000307102 5 3d MAP2K1 A52 52 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot-linked V:1 0.0261 1 1 skcm:1 ENST00000307102 5 3d MAP2K1 F53 53 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot V:1|I:1|L:4 0.0261 6 4 coadread:3|stad:1|skcm:1|luad:1 ENST00000307102 5 3d MAP2K1 Q56 56 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot-linked P:1 0.0261 1 1 luad:1 ENST00000307102 5 3d MAP2K1 K57 57 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot T:3|N:7 0.0261 10 6 prad:1|stad:1|dlbc:1|hnsc:1|skcm:2|luad:4 ENST00000307102 5 3d MAP2K1 G128 128 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot-linked D:2|V:1 0.0261 3 2 coadread:2|luad:1 ENST00000307102 5 3d MAP2K1 Y130 130 294 3zm4_A(0.0261);3eqh_A(0.0297);3eqg_A(0.0299);3zls_A(0.0281);3eqf_A(0.0293);3sls_B(0.0261);3zlx_A(0.0277);3zlw_A(0.0291);3eqi_A(0.029);3zly_A(0.0267);3eqd_A(0.0319);3eqc_A(0.0279);3w8q_A(0.0286) Hotspot-linked C:2 0.0261 2 2 dlbc:1|lihc:1 ENST00000307102 5 3d DPP6 I262 262 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive M:1 0.0264 1 1 hnsc:1 ENST00000377770 3 3d DPP6 A303 303 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:2 0.0264 2 2 stad:1|esca:1 ENST00000377770 3 3d DPP6 W305 305 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive L:1 0.0264 1 1 lusc:1 ENST00000377770 3 3d DPP6 L313 313 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive I:1 0.0264 1 1 hnsc:1 ENST00000377770 3 3d DPP6 A314 314 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:1 0.0264 1 1 stad:1 ENST00000377770 3 3d DPP6 Y315 315 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive C:1 0.0264 1 1 gbm:1 ENST00000377770 3 3d DPP6 A316 316 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:1 0.0264 1 1 hnsc:1 ENST00000377770 3 3d DPP6 A317 317 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:2 0.0264 2 2 cll:1|cesc:1 ENST00000377770 3 3d DPP6 S355 355 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive F:1 0.0264 1 1 skcm:1 ENST00000377770 3 3d DPP6 L356 356 295 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive Q:1 0.0264 1 1 lusc:1 ENST00000377770 3 3d DPP6 L288 288 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive F:1 0.0264 1 1 hnsc:1 ENST00000377770 3 3d DPP6 I318 318 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:1 0.0264 1 1 luad:1 ENST00000377770 3 3d UNC79 G2457 2457 297 2cqg_A(0.0264) Cluster-exclusive E:1 0.0264 1 1 skcm:1 ENST00000393151 2 3d UNC79 P2459 2459 297 2cqg_A(0.0264) Cluster-exclusive S:3 0.0264 3 2 skcm:2|ucec:1 ENST00000393151 2 3d UNC79 L2472 2472 297 2cqg_A(0.0264) Cluster-exclusive V:1 0.0264 1 1 luad:1 ENST00000393151 2 3d UNC79 H2474 2474 297 2cqg_A(0.0264) Cluster-exclusive Y:1 0.0264 1 1 skcm:1 ENST00000393151 2 3d UNC79 A2475 2475 297 2cqg_A(0.0264) Cluster-exclusive T:1 0.0264 1 1 thca:1 ENST00000393151 2 3d UNC79 V2491 2491 297 2cqg_A(0.0264) Cluster-exclusive I:1 0.0264 1 1 stad:1 ENST00000393151 2 3d UNC79 A2492 2492 297 2cqg_A(0.0264) Cluster-exclusive T:1 0.0264 1 1 coadread:1 ENST00000393151 2 3d TP53 L137 137 298 2fej_A(0.0265) Hotspot-linked Q:1 0.0265 1 1 hnsc:1 ENST00000269305 4 3d TP53 A138 138 298 2fej_A(0.0265) Hotspot-linked P:1|T:1|V:4 0.0265 6 5 coadread:2|gbm:1|hnsc:1|ov:1|cscc:1 ENST00000269305 4 3d TP53 Y236 236 298 2fej_A(0.0265) Hotspot C:16|D:2|N:2 0.0265 20 11 brca:1|paad:1|coadread:1|prad:1|stad:1|hnsc:6|ov:2|lusc:1|lgg:3|luad:2|cscc:1 ENST00000269305 4 3d COPE V54 54 299 3mkr_A(0.0266) Cluster-exclusive I:1 0.0266 1 1 esca:1 ENST00000262812 4 3d COPE S77 77 299 3mkr_A(0.0266) Cluster-exclusive L:1 0.0266 1 1 brca:1 ENST00000262812 4 3d COPE A78 78 299 3mkr_A(0.0266) Cluster-exclusive T:1 0.0266 1 1 blca:1 ENST00000262812 4 3d COPE P79 79 299 3mkr_A(0.0266) Cluster-exclusive S:1 0.0266 1 1 skcm:1 ENST00000262812 4 3d COPE L81 81 299 3mkr_A(0.0266) Cluster-exclusive F:1 0.0266 1 1 skcm:1 ENST00000262812 4 3d NCF1 E211 211 300 1ng2_A(0.0316);1uec_A(0.0267);1ov3_A(0.0591) Cluster-exclusive Q:1|K:1 0.0267 2 2 ucs:1|skcm:1 ENST00000289473 4 3d NCF1 P212 212 300 1ng2_A(0.0316);1uec_A(0.0267);1ov3_A(0.0591) Cluster-exclusive T:1 0.0267 1 1 stad:1 ENST00000289473 4 3d NCF1 P216 216 300 1ng2_A(0.0316);1uec_A(0.0267);1ov3_A(0.0591) Cluster-exclusive S:1 0.0267 1 1 cll:1 ENST00000289473 4 3d NCF1 E218 218 300 1ng2_A(0.0316);1uec_A(0.0267);1ov3_A(0.0591) Cluster-exclusive K:2 0.0267 2 2 gbm:1|nbl:1 ENST00000289473 4 3d ABCB1 R467 467 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive W:5|L:1 0.0269 6 4 prad:2|mbl:1|lihc:1|ucec:2 ENST00000265724 3 3d ABCB1 E468 468 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive K:3 0.0269 3 1 skcm:3 ENST00000265724 3 3d ABCB1 G471 471 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive D:1 0.0269 1 1 cscc:1 ENST00000265724 3 3d ABCB1 R492 492 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive L:1 0.0269 1 1 luad:1 ENST00000265724 3 3d ABCB1 R543 543 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive H:1 0.0269 1 1 ucec:1 ENST00000265724 3 3d ABCB1 L545 545 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive Q:1 0.0269 1 1 acc:1 ENST00000265724 3 3d ABCB1 R547 547 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive C:2 0.0269 2 2 hnsc:1|skcm:1 ENST00000265724 3 3d ABCB1 N548 548 302 4m2s_B(0.0395);4m2t_B(0.047);4ksc_A(0.04);4ksb_A(0.0358);4lsg_A(0.0269);4ksd_A(0.036) Cluster-exclusive K:1 0.0269 1 1 luad:1 ENST00000265724 3 3d DCN M199 199 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive I:1 0.027 1 1 kirc:1 ENST00000052754 5 3d DCN K201 201 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive Q:1 0.027 1 1 lihc:1 ENST00000052754 5 3d DCN P220 220 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive H:1 0.027 1 1 luad:1 ENST00000052754 5 3d DCN P221 221 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive S:2|H:1 0.027 3 2 skcm:2|ucec:1 ENST00000052754 5 3d DCN S222 222 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive F:2 0.027 2 2 hnsc:1|skcm:1 ENST00000052754 5 3d DCN T224 224 303 1xec_A(0.027);1xku_A(0.03);1xcd_A(0.0272) Cluster-exclusive M:3 0.027 3 3 coadread:1|stad:1|lgg:1 ENST00000052754 5 3d H3C10 R9 9 304 2kwk_B(0.027) Cluster-exclusive G:1 0.027 1 1 ov:1 ENST00000369163 2 3d MAPK1 P319 319 306 4gsb_A(0.0271) Hotspot-linked S:1 0.0271 1 1 skcm:1 ENST00000215832 6 3d ECT2L K203 203 307 4l7e_A(0.0287);4l7e_B(0.0335);4l1j_B(0.0338);4l7w_A(0.0271);3hlt_C(0.0599);4l1j_A(0.0317);4dmb_A(0.0287);4dmb_B(0.0314);3hlt_A(0.0719) Cluster-exclusive N:1 0.0271 1 1 coadread:1 ENST00000367682 2 3d ECT2L V204 204 307 4l7e_A(0.0287);4l7e_B(0.0335);4l1j_B(0.0338);4l7w_A(0.0271);3hlt_C(0.0599);4l1j_A(0.0317);4dmb_A(0.0287);4dmb_B(0.0314);3hlt_A(0.0719) Cluster-exclusive A:1 0.0271 1 1 skcm:1 ENST00000367682 2 3d ECT2L R205 205 307 4l7e_A(0.0287);4l7e_B(0.0335);4l1j_B(0.0338);4l7w_A(0.0271);3hlt_C(0.0599);4l1j_A(0.0317);4dmb_A(0.0287);4dmb_B(0.0314);3hlt_A(0.0719) Cluster-exclusive Q:1 0.0271 1 1 luad:1 ENST00000367682 2 3d ECT2L P207 207 307 4l7e_A(0.0287);4l7e_B(0.0335);4l1j_B(0.0338);4l7w_A(0.0271);3hlt_C(0.0599);4l1j_A(0.0317);4dmb_A(0.0287);4dmb_B(0.0314);3hlt_A(0.0719) Cluster-exclusive A:1 0.0271 1 1 luad:1 ENST00000367682 2 3d ECT2L A239 239 307 4l7e_A(0.0287);4l7e_B(0.0335);4l1j_B(0.0338);4l7w_A(0.0271);3hlt_C(0.0599);4l1j_A(0.0317);4dmb_A(0.0287);4dmb_B(0.0314);3hlt_A(0.0719) Cluster-exclusive G:1 0.0271 1 1 stad:1 ENST00000367682 2 3d RBP2 V35 35 309 4efg_B(0.0371);4ede_A(0.0357);4ede_B(0.0339);4efg_A(0.0389);4qzu_D(0.0648);4qzt_D(0.0572);4qzu_C(0.0553);4gkc_A(0.0303);4qzt_A(0.0628);4qzt_C(0.0589);4qzu_B(0.0607);4qzt_B(0.0608);4qzu_A(0.062);4gkc_B(0.0321);4ruu_B(0.0478);4ruu_A(0.0438);4eej_A(0.03);4eej_B(0.0273);4qyp_D(0.0558);2rct_A(0.0582);4qyp_C(0.0571);4exz_A(0.0412);2rcq_A(0.0601);4qyn_B(0.0531);4qyn_A(0.0595);4qyp_B(0.0615);4qyp_A(0.0616);1opb_A(0.0337);1opa_A(0.0357) Cluster-exclusive E:1 0.0273 1 1 luad:1 ENST00000232217 2 3d KCNH5 D520 520 310 2x2m_A(0.0277);2ivu_A(0.0273) Cluster-exclusive N:1 0.0273 1 1 skcm:1 ENST00000322893 7 3d KCNH5 E522 522 310 2x2m_A(0.0277);2ivu_A(0.0273) Cluster-exclusive K:1 0.0273 1 1 ucec:1 ENST00000322893 7 3d KCNH5 K523 523 310 2x2m_A(0.0277);2ivu_A(0.0273) Cluster-exclusive N:1 0.0273 1 1 ucec:1 ENST00000322893 7 3d KCNH5 L525 525 310 2x2m_A(0.0277);2ivu_A(0.0273) Cluster-exclusive F:1 0.0273 1 1 skcm:1 ENST00000322893 7 3d LRRC55 E223 223 313 2uzq_A(0.0276);2a2k_A(0.0995) Cluster-exclusive D:1 0.0276 1 1 blca:1 ENST00000497933 1 3d LRRC55 E226 226 313 2uzq_A(0.0276);2a2k_A(0.0995) Cluster-exclusive D:1 0.0276 1 1 stad:1 ENST00000497933 1 3d LRRC55 G227 227 313 2uzq_A(0.0276);2a2k_A(0.0995) Cluster-exclusive S:1 0.0276 1 1 paad:1 ENST00000497933 1 3d LRRC55 G230 230 313 2uzq_A(0.0276);2a2k_A(0.0995) Cluster-exclusive W:1 0.0276 1 1 luad:1 ENST00000497933 1 3d LRRC55 L231 231 313 2uzq_A(0.0276);2a2k_A(0.0995) Cluster-exclusive V:1 0.0276 1 1 thca:1 ENST00000497933 1 3d ITGB1 M149 149 314 4wk0_B(0.0281);4wjk_B(0.0316) Cluster-exclusive V:1|I:1|L:1 0.0281 3 3 brca:1|skcm:1|lusc:1 ENST00000302278 3 3d ITGB1 D158 158 314 4wk0_B(0.0281);4wjk_B(0.0316) Cluster-exclusive N:3 0.0281 3 2 coadread:1|hnsc:2 ENST00000302278 3 3d ITGB1 V162 162 314 4wk0_B(0.0281);4wjk_B(0.0316) Cluster-exclusive G:1 0.0281 1 1 hnsc:1 ENST00000302278 3 3d ITGB1 V275 275 314 4wk0_B(0.0281);4wjk_B(0.0316) Cluster-exclusive G:2 0.0281 2 2 brca:1|mmyl:1 ENST00000302278 3 3d ITGB1 F276 276 314 4wk0_B(0.0281);4wjk_B(0.0316) Cluster-exclusive L:1 0.0281 1 1 brca:1 ENST00000302278 3 3d GRIA2 A473 473 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive D:1 0.0282 1 1 skcm:1 ENST00000264426 9 3d GRIA2 R474 474 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive M:2 0.0282 2 2 skcm:1|luad:1 ENST00000264426 9 3d GRIA2 D475 475 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive N:2 0.0282 2 2 skcm:1|cscc:1 ENST00000264426 9 3d GRIA2 I480 480 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive F:1 0.0282 1 1 mmyl:1 ENST00000264426 9 3d GRIA2 W481 481 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive C:1|G:1 0.0282 2 2 hnsc:1|ov:1 ENST00000264426 9 3d GRIA2 G483 483 315 1gr2_A(0.0298);1ftk_A(0.0282) Cluster-exclusive V:1 0.0282 1 1 luad:1 ENST00000264426 9 3d HDAC6 H500 500 316 1z0q_A(0.0282);1amb_A(0.0559);2llm_A(0.0765);1amc_A(0.0532) Cluster-exclusive R:1 0.0282 1 1 stad:1 ENST00000334136 5 3d HDAC6 Q505 505 316 1z0q_A(0.0282);1amb_A(0.0559);2llm_A(0.0765);1amc_A(0.0532) Cluster-exclusive P:1 0.0282 1 1 coadread:1 ENST00000334136 5 3d HDAC6 I507 507 316 1z0q_A(0.0282);1amb_A(0.0559);2llm_A(0.0765);1amc_A(0.0532) Cluster-exclusive V:1|M:1 0.0282 2 2 cesc:1|kirc:1 ENST00000334136 5 3d HDAC6 I510 510 316 1z0q_A(0.0282);1amb_A(0.0559);2llm_A(0.0765);1amc_A(0.0532) Cluster-exclusive T:1 0.0282 1 1 kirc:1 ENST00000334136 5 3d HDAC6 M511 511 316 1z0q_A(0.0282);1amb_A(0.0559);2llm_A(0.0765);1amc_A(0.0532) Cluster-exclusive V:1 0.0282 1 1 stad:1 ENST00000334136 5 3d TUBB4A R251 251 317 4aqv_B(0.0282);4aqw_B(0.0284) Cluster-exclusive C:1|H:1 0.0282 2 2 lgg:1|luad:1 ENST00000264071 2 3d TUBB4A A254 254 317 4aqv_B(0.0282);4aqw_B(0.0284) Cluster-exclusive D:1|G:1 0.0282 2 2 blca:1|ucec:1 ENST00000264071 2 3d TUBB4A V255 255 317 4aqv_B(0.0282);4aqw_B(0.0284) Cluster-exclusive I:2 0.0282 2 2 stad:1|ucec:1 ENST00000264071 2 3d PDE11A D236 236 319 2nms_A(0.0284) Cluster-exclusive H:1 0.0284 1 1 gbm:1 ENST00000286063 6 3d PDE11A G291 291 319 2nms_A(0.0284) Cluster-exclusive R:1|V:1 0.0284 2 2 stad:1|lusc:1 ENST00000286063 6 3d PDE11A Q304 304 319 2nms_A(0.0284) Cluster-exclusive H:1 0.0284 1 1 ucec:1 ENST00000286063 6 3d PDE11A D305 305 319 2nms_A(0.0284) Cluster-exclusive Y:1|N:1 0.0284 2 2 coadread:1|cscc:1 ENST00000286063 6 3d PDE11A R306 306 319 2nms_A(0.0284) Cluster-exclusive Q:1 0.0284 1 1 cscc:1 ENST00000286063 6 3d PDE11A F308 308 319 2nms_A(0.0284) Cluster-exclusive L:1 0.0284 1 1 skcm:1 ENST00000286063 6 3d PDE11A G317 317 319 2nms_A(0.0284) Cluster-exclusive A:1 0.0284 1 1 lusc:1 ENST00000286063 6 3d PDE11A K319 319 319 2nms_A(0.0284) Cluster-exclusive N:1 0.0284 1 1 luad:1 ENST00000286063 6 3d EPHB1 Y740 740 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive H:1 0.0286 1 1 stad:1 ENST00000398015 3 3d EPHB1 H742 742 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive N:1 0.0286 1 1 skcm:1 ENST00000398015 3 3d EPHB1 R743 743 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive Q:1 0.0286 1 1 stad:1 ENST00000398015 3 3d EPHB1 D744 744 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive Y:1|N:1 0.0286 2 2 cscc:1|luad:1 ENST00000398015 3 3d EPHB1 V760 760 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive A:1 0.0286 1 1 cll:1 ENST00000398015 3 3d EPHB1 D762 762 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive E:1|N:4 0.0286 5 4 stad:1|gbm:1|skcm:2|ucec:1 ENST00000398015 3 3d EPHB1 R767 767 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive C:1 0.0286 1 1 esca:1 ENST00000398015 3 3d EPHB1 D806 806 320 3zfx_D(0.0296);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286);3zfx_I(0.0308);3zfx_F(0.0315) Cluster-exclusive N:2 0.0286 2 2 coadread:1|stad:1 ENST00000398015 3 3d EPHB1 R748 748 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive S:1|K:1 0.0286 2 1 luad:2 ENST00000398015 3 3d EPHB1 N749 749 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive K:1 0.0286 1 1 coadread:1 ENST00000398015 3 3d SUMO3 I33 33 322 3uio_B(0.0565);3uin_B(0.0549);2ckh_B(0.0493);2io1_F(0.0471);2rpq_A(0.0484);2awt_A(0.0286);1wm2_A(0.0632);2io1_B(0.0399);1wm3_A(0.0698);2io1_D(0.0455);2io3_B(0.0384);1u4a_A(0.0628);2d07_B(0.0611);2io0_B(0.056);2iyd_B(0.0529);1wz0_A(0.042);4bkg_A(0.0626) Cluster-exclusive M:1 0.0286 1 1 esca:1 ENST00000332859 6 3d SUMO3 K34 34 322 3uio_B(0.0565);3uin_B(0.0549);2ckh_B(0.0493);2io1_F(0.0471);2rpq_A(0.0484);2awt_A(0.0286);1wm2_A(0.0632);2io1_B(0.0399);1wm3_A(0.0698);2io1_D(0.0455);2io3_B(0.0384);1u4a_A(0.0628);2d07_B(0.0611);2io0_B(0.056);2iyd_B(0.0529);1wz0_A(0.042);4bkg_A(0.0626) Cluster-exclusive N:1 0.0286 1 1 prad:1 ENST00000332859 6 3d SUMO3 T37 37 322 3uio_B(0.0565);3uin_B(0.0549);2ckh_B(0.0493);2io1_F(0.0471);2rpq_A(0.0484);2awt_A(0.0286);1wm2_A(0.0632);2io1_B(0.0399);1wm3_A(0.0698);2io1_D(0.0455);2io3_B(0.0384);1u4a_A(0.0628);2d07_B(0.0611);2io0_B(0.056);2iyd_B(0.0529);1wz0_A(0.042);4bkg_A(0.0626) Cluster-exclusive M:1 0.0286 1 1 stad:1 ENST00000332859 6 3d SUMO3 P38 38 322 3uio_B(0.0565);3uin_B(0.0549);2ckh_B(0.0493);2io1_F(0.0471);2rpq_A(0.0484);2awt_A(0.0286);1wm2_A(0.0632);2io1_B(0.0399);1wm3_A(0.0698);2io1_D(0.0455);2io3_B(0.0384);1u4a_A(0.0628);2d07_B(0.0611);2io0_B(0.056);2iyd_B(0.0529);1wz0_A(0.042);4bkg_A(0.0626) Cluster-exclusive L:1 0.0286 1 1 coadread:1 ENST00000332859 6 3d PLEKHA6 R80 80 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive C:1 0.0287 1 1 stad:1 ENST00000272203 3 3d PLEKHA6 W81 81 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive C:1 0.0287 1 1 kirc:1 ENST00000272203 3 3d PLEKHA6 F82 82 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive L:3 0.0287 3 3 prad:1|ov:1|skcm:1 ENST00000272203 3 3d PLEKHA6 V83 83 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive I:1 0.0287 1 1 hnsc:1 ENST00000272203 3 3d PLEKHA6 F90 90 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive L:1 0.0287 1 1 esca:1 ENST00000272203 3 3d PLEKHA6 Y92 92 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive C:1 0.0287 1 1 luad:1 ENST00000272203 3 3d PLEKHA6 D94 94 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive N:1 0.0287 1 1 skcm:1 ENST00000272203 3 3d PLEKHA6 E95 95 323 2yry_A(0.0474);2d9y_A(0.0287) Cluster-exclusive D:1 0.0287 1 1 ucec:1 ENST00000272203 3 3d TGFBI T504 504 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive N:1 0.029 1 1 ucec:1 ENST00000442011 2 3d TGFBI V505 505 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive F:1 0.029 1 1 esca:1 ENST00000442011 2 3d TGFBI D507 507 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive V:1 0.029 1 1 ucec:1 ENST00000442011 2 3d TGFBI V508 508 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive I:1 0.029 1 1 luad:1 ENST00000442011 2 3d TGFBI L509 509 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive P:2 0.029 2 2 coadread:1|lihc:1 ENST00000442011 2 3d TGFBI L531 531 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive V:1 0.029 1 1 hnsc:1 ENST00000442011 2 3d TGFBI T621 621 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive P:1 0.029 1 1 skcm:1 ENST00000442011 2 3d TGFBI V625 625 324 2ltb_A(0.029);2ltc_A(0.0382);1x3b_A(0.0373) Cluster-exclusive A:1 0.029 1 1 acc:1 ENST00000442011 2 3d TGFBI R533 533 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive L:1 0.029 1 1 mbl:1 ENST00000442011 2 3d RYR2 A266 266 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive P:1|S:1|T:1 0.0292 3 2 coadread:1|lusc:2 ENST00000366574 2 3d RYR2 S268 268 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive F:1 0.0292 1 1 coadread:1 ENST00000366574 2 3d RYR2 H270 270 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive Q:1 0.0292 1 1 cscc:1 ENST00000366574 2 3d RYR2 R272 272 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive H:1|L:1 0.0292 2 2 stad:1|luad:1 ENST00000366574 2 3d RYR2 S273 273 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive C:1|F:2 0.0292 3 2 cscc:2|luad:1 ENST00000366574 2 3d RYR2 N487 487 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive T:1 0.0292 1 1 ucec:1 ENST00000366574 2 3d RYR2 L488 488 326 4l4i_A(0.0293);4l4h_A(0.0292) Cluster-exclusive I:2 0.0292 2 2 coadread:1|luad:1 ENST00000366574 2 3d SLC12A2 V283 283 327 3i7h_A(0.0835);2hye_A(0.0797);4a0l_A(0.0856);3i7l_A(0.0795);3i7k_A(0.0777);4a0k_C(0.0814);3i7n_A(0.0878);4a0b_C(0.0795);4a0a_A(0.0293);4a0b_A(0.0756);4a09_A(0.0786);3i7p_A(0.091);2b5l_A(0.08);3i7o_A(0.0877);2b5m_A(0.0856);4a08_A(0.0831);4a11_A(0.0863);3e0c_A(0.0783);3i8c_A(0.0803);3i8e_A(0.0769);3i89_A(0.0863);4e54_A(0.0858);3ei3_A(0.0943);3ei4_A(0.0887);3ei1_A(0.0849);3ei2_A(0.0872);4e5z_A(0.0675) Cluster-exclusive A:1 0.0293 1 1 coadread:1 ENST00000262461 2 3d SLC12A2 K284 284 327 3i7h_A(0.0835);2hye_A(0.0797);4a0l_A(0.0856);3i7l_A(0.0795);3i7k_A(0.0777);4a0k_C(0.0814);3i7n_A(0.0878);4a0b_C(0.0795);4a0a_A(0.0293);4a0b_A(0.0756);4a09_A(0.0786);3i7p_A(0.091);2b5l_A(0.08);3i7o_A(0.0877);2b5m_A(0.0856);4a08_A(0.0831);4a11_A(0.0863);3e0c_A(0.0783);3i8c_A(0.0803);3i8e_A(0.0769);3i89_A(0.0863);4e54_A(0.0858);3ei3_A(0.0943);3ei4_A(0.0887);3ei1_A(0.0849);3ei2_A(0.0872);4e5z_A(0.0675) Cluster-exclusive T:1 0.0293 1 1 coadread:1 ENST00000262461 2 3d SLC12A2 I306 306 327 3i7h_A(0.0835);2hye_A(0.0797);4a0l_A(0.0856);3i7l_A(0.0795);3i7k_A(0.0777);4a0k_C(0.0814);3i7n_A(0.0878);4a0b_C(0.0795);4a0a_A(0.0293);4a0b_A(0.0756);4a09_A(0.0786);3i7p_A(0.091);2b5l_A(0.08);3i7o_A(0.0877);2b5m_A(0.0856);4a08_A(0.0831);4a11_A(0.0863);3e0c_A(0.0783);3i8c_A(0.0803);3i8e_A(0.0769);3i89_A(0.0863);4e54_A(0.0858);3ei3_A(0.0943);3ei4_A(0.0887);3ei1_A(0.0849);3ei2_A(0.0872);4e5z_A(0.0675) Cluster-exclusive V:1 0.0293 1 1 luad:1 ENST00000262461 2 3d SLC12A2 W310 310 327 3i7h_A(0.0835);2hye_A(0.0797);4a0l_A(0.0856);3i7l_A(0.0795);3i7k_A(0.0777);4a0k_C(0.0814);3i7n_A(0.0878);4a0b_C(0.0795);4a0a_A(0.0293);4a0b_A(0.0756);4a09_A(0.0786);3i7p_A(0.091);2b5l_A(0.08);3i7o_A(0.0877);2b5m_A(0.0856);4a08_A(0.0831);4a11_A(0.0863);3e0c_A(0.0783);3i8c_A(0.0803);3i8e_A(0.0769);3i89_A(0.0863);4e54_A(0.0858);3ei3_A(0.0943);3ei4_A(0.0887);3ei1_A(0.0849);3ei2_A(0.0872);4e5z_A(0.0675) Cluster-exclusive C:1 0.0293 1 1 luad:1 ENST00000262461 2 3d SLC12A2 V312 312 327 3i7h_A(0.0835);2hye_A(0.0797);4a0l_A(0.0856);3i7l_A(0.0795);3i7k_A(0.0777);4a0k_C(0.0814);3i7n_A(0.0878);4a0b_C(0.0795);4a0a_A(0.0293);4a0b_A(0.0756);4a09_A(0.0786);3i7p_A(0.091);2b5l_A(0.08);3i7o_A(0.0877);2b5m_A(0.0856);4a08_A(0.0831);4a11_A(0.0863);3e0c_A(0.0783);3i8c_A(0.0803);3i8e_A(0.0769);3i89_A(0.0863);4e54_A(0.0858);3ei3_A(0.0943);3ei4_A(0.0887);3ei1_A(0.0849);3ei2_A(0.0872);4e5z_A(0.0675) Cluster-exclusive L:1 0.0293 1 1 coadread:1 ENST00000262461 2 3d HDAC8 D333 333 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive N:1 0.0294 1 1 esca:1 ENST00000373573 3 3d UVSSA S459 459 329 1xwd_B(0.0299);1fl7_D(0.0301);4ay9_B(0.0313);1fl7_B(0.0298) Cluster-exclusive F:1 0.0298 1 1 skcm:1 ENST00000389851 4 3d UVSSA A460 460 329 1xwd_B(0.0299);1fl7_D(0.0301);4ay9_B(0.0313);1fl7_B(0.0298) Cluster-exclusive P:1 0.0298 1 1 luad:1 ENST00000389851 4 3d UVSSA R552 552 329 1xwd_B(0.0299);1fl7_D(0.0301);4ay9_B(0.0313);1fl7_B(0.0298) Cluster-exclusive H:1 0.0298 1 1 ucec:1 ENST00000389851 4 3d RBBP7 R339 339 331 2xu7_A(0.03) Cluster-exclusive S:1 0.03 1 1 coadread:1 ENST00000380087 2 3d RBBP7 H369 369 331 2xu7_A(0.03) Cluster-exclusive L:1 0.03 1 1 blca:1 ENST00000380087 2 3d H2BC5 E3 3 334 2m0o_A(0.0308) Cluster-exclusive Q:2|K:1 0.0308 3 3 blca:1|hnsc:1|ov:1 ENST00000289316 2 3d H2BC5 S7 7 334 2m0o_A(0.0308) Cluster-exclusive Y:1 0.0308 1 1 ucec:1 ENST00000289316 2 3d H2BC5 P9 9 334 2m0o_A(0.0308) Cluster-exclusive L:1 0.0308 1 1 brca:1 ENST00000289316 2 3d H2BC5 A10 10 334 2m0o_A(0.0308) Cluster-exclusive D:1|V:1|G:1 0.0308 3 3 brca:1|ucec:1|luad:1 ENST00000289316 2 3d H2BC5 A22 22 334 2m0o_A(0.0308) Cluster-exclusive G:1 0.0308 1 1 ov:1 ENST00000289316 2 3d H2BC5 Q23 23 334 2m0o_A(0.0308) Cluster-exclusive L:1 0.0308 1 1 hnsc:1 ENST00000289316 2 3d H2BC5 K35 35 334 2m0o_A(0.0308) Cluster-exclusive R:1 0.0308 1 1 ucec:1 ENST00000289316 2 3d H2BC5 S37 37 334 2m0o_A(0.0308) Cluster-exclusive R:1|C:1 0.0308 2 2 stad:1|hnsc:1 ENST00000289316 2 3d H2BC5 V45 45 334 2m0o_A(0.0308) Cluster-exclusive L:1 0.0308 1 1 esca:1 ENST00000289316 2 3d H2BC5 D52 52 334 2m0o_A(0.0308) Cluster-exclusive Y:1|N:1 0.0308 2 2 lusm:1|stad:1 ENST00000289316 2 3d PLEKHH2 E106 106 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive K:1 0.0308 1 1 skcm:1 ENST00000282406 4 3d MZF1 P40 40 336 2fi2_A(0.031) Cluster-exclusive H:1 0.031 1 1 lihc:1 ENST00000215057 2 3d MZF1 E41 41 336 2fi2_A(0.031) Cluster-exclusive K:1 0.031 1 1 blca:1 ENST00000215057 2 3d MZF1 R44 44 336 2fi2_A(0.031) Cluster-exclusive C:1 0.031 1 1 acc:1 ENST00000215057 2 3d MZF1 R46 46 336 2fi2_A(0.031) Cluster-exclusive H:1 0.031 1 1 coadread:1 ENST00000215057 2 3d MZF1 F47 47 336 2fi2_A(0.031) Cluster-exclusive S:1 0.031 1 1 kirp:1 ENST00000215057 2 3d MZF1 R48 48 336 2fi2_A(0.031) Cluster-exclusive Q:1 0.031 1 1 hnsc:1 ENST00000215057 2 3d MZF1 R108 108 336 2fi2_A(0.031) Cluster-exclusive L:1 0.031 1 1 stad:1 ENST00000215057 2 3d PCBD2 Q72 72 337 4c45_A(0.031) Cluster-exclusive H:1 0.031 1 1 luad:1 ENST00000254908 6 3d PCBD2 M77 77 337 4c45_A(0.031) Cluster-exclusive I:1 0.031 1 1 kirc:1 ENST00000254908 6 3d PCBD2 S78 78 337 4c45_A(0.031) Cluster-exclusive Y:1 0.031 1 1 kirp:1 ENST00000254908 6 3d PCBD2 R79 79 337 4c45_A(0.031) Cluster-exclusive Q:1 0.031 1 1 skcm:1 ENST00000254908 6 3d ASMT D35 35 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive H:1 0.0311 1 1 ucec:1 ENST00000381229 4 3d ASMT L37 37 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive V:1 0.0311 1 1 luad:1 ENST00000381229 4 3d ASMT A38 38 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive S:1 0.0311 1 1 luad:1 ENST00000381229 4 3d ASMT G42 42 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive R:1 0.0311 1 1 skcm:1 ENST00000381229 4 3d ASMT V49 49 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive M:1 0.0311 1 1 skcm:1 ENST00000381229 4 3d ASMT Y84 84 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive C:1 0.0311 1 1 thca:1 ENST00000381229 4 3d ASMT R85 85 338 4a6d_A(0.0315);4a6e_A(0.0311) Cluster-exclusive Q:1|L:1 0.0311 2 2 skcm:1|ucec:1 ENST00000381229 4 3d SYK F17 17 339 1a81_E(0.0311);1a81_C(0.0428);1a81_I(0.0369) Cluster-exclusive H:1 0.0311 1 1 skcm:1 ENST00000375746 1 3d SYK R42 42 339 1a81_E(0.0311);1a81_C(0.0428);1a81_I(0.0369) Cluster-exclusive H:1 0.0311 1 1 prad:1 ENST00000375746 1 3d SYK S44 44 339 1a81_E(0.0311);1a81_C(0.0428);1a81_I(0.0369) Cluster-exclusive I:1|N:1 0.0311 2 2 skcm:1|lihc:1 ENST00000375746 1 3d SYK R45 45 339 1a81_E(0.0311);1a81_C(0.0428);1a81_I(0.0369) Cluster-exclusive H:1 0.0311 1 1 stad:1 ENST00000375746 1 3d SYK A52 52 339 1a81_E(0.0311);1a81_C(0.0428);1a81_I(0.0369) Cluster-exclusive T:2 0.0311 2 2 coadread:1|luad:1 ENST00000375746 1 3d ACAT1 Q211 211 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive R:1 0.0311 1 1 lihc:1 ENST00000265838 4 3d ACAT1 N282 282 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive S:1 0.0311 1 1 paad:1 ENST00000265838 4 3d ACAT1 A355 355 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive V:1 0.0311 1 1 paad:1 ENST00000265838 4 3d ACAT1 S357 357 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive C:1 0.0311 1 1 cesc:1 ENST00000265838 4 3d ACAT1 A362 362 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive T:1 0.0311 1 1 stad:1 ENST00000265838 4 3d ACAT1 V381 381 340 2f2s_D(0.0344);2ibu_C(0.0311) Cluster-exclusive A:1 0.0311 1 1 coadread:1 ENST00000265838 4 3d CUL5 R253 253 341 Cluster-exclusive Q:1 0.0313 1 1 ucec:1 ENST00000393094 2 3d CDH1 R222 222 342 2o72_A(0.0314) Cluster-exclusive G:1 0.0314 1 1 stad:1 ENST00000261769 5 3d CDH1 D254 254 342 2o72_A(0.0314) Cluster-exclusive Y:4|N:2 0.0314 6 2 stad:5|esca:1 ENST00000261769 5 3d CDH1 N256 256 342 2o72_A(0.0314) Cluster-exclusive I:1 0.0314 1 1 prad:1 ENST00000261769 5 3d CDH1 D257 257 342 2o72_A(0.0314) Cluster-exclusive G:1|N:1 0.0314 2 1 stad:2 ENST00000261769 5 3d CDH1 D288 288 342 2o72_A(0.0314) Cluster-exclusive V:1|N:1 0.0314 2 2 brca:1|stad:1 ENST00000261769 5 3d CDH1 A289 289 342 2o72_A(0.0314) Cluster-exclusive V:1 0.0314 1 1 coadread:1 ENST00000261769 5 3d CDH1 D290 290 342 2o72_A(0.0314) Cluster-exclusive G:1 0.0314 1 1 stad:1 ENST00000261769 5 3d CDH1 D291 291 342 2o72_A(0.0314) Cluster-exclusive N:1 0.0314 1 1 coadread:1 ENST00000261769 5 3d VCL F212 212 343 2gww_A(0.0387);1zvz_A(0.0381);4ehp_A(0.0399);1rke_A(0.0404);3s90_B(0.0409);1zw3_A(0.0373);1xwj_A(0.0368);1zw2_A(0.0401);1rkc_A(0.0336);3s90_A(0.0422);4dj9_A(0.0376);1u6h_A(0.0377);1t01_A(0.0404);3rf3_A(0.0669);3rf3_B(0.0649);3tj5_A(0.0372);2ibf_A(0.0407);3tj6_A(0.0352);1syq_A(0.038);2hsq_A(0.0382);4e18_A(0.0317);1ydi_A(0.036);2gdc_A(0.0365);3zdl_A(0.0364) Cluster-exclusive C:1 0.0317 1 1 lgg:1 ENST00000211998 4 3d VCL A226 226 343 2gww_A(0.0387);1zvz_A(0.0381);4ehp_A(0.0399);1rke_A(0.0404);3s90_B(0.0409);1zw3_A(0.0373);1xwj_A(0.0368);1zw2_A(0.0401);1rkc_A(0.0336);3s90_A(0.0422);4dj9_A(0.0376);1u6h_A(0.0377);1t01_A(0.0404);3rf3_A(0.0669);3rf3_B(0.0649);3tj5_A(0.0372);2ibf_A(0.0407);3tj6_A(0.0352);1syq_A(0.038);2hsq_A(0.0382);4e18_A(0.0317);1ydi_A(0.036);2gdc_A(0.0365);3zdl_A(0.0364) Cluster-exclusive T:1 0.0317 1 1 coadread:1 ENST00000211998 4 3d VCL R230 230 343 2gww_A(0.0387);1zvz_A(0.0381);4ehp_A(0.0399);1rke_A(0.0404);3s90_B(0.0409);1zw3_A(0.0373);1xwj_A(0.0368);1zw2_A(0.0401);1rkc_A(0.0336);3s90_A(0.0422);4dj9_A(0.0376);1u6h_A(0.0377);1t01_A(0.0404);3rf3_A(0.0669);3rf3_B(0.0649);3tj5_A(0.0372);2ibf_A(0.0407);3tj6_A(0.0352);1syq_A(0.038);2hsq_A(0.0382);4e18_A(0.0317);1ydi_A(0.036);2gdc_A(0.0365);3zdl_A(0.0364) Cluster-exclusive C:1|H:1 0.0317 2 2 coadread:1|skcm:1 ENST00000211998 4 3d VCL N231 231 343 2gww_A(0.0387);1zvz_A(0.0381);4ehp_A(0.0399);1rke_A(0.0404);3s90_B(0.0409);1zw3_A(0.0373);1xwj_A(0.0368);1zw2_A(0.0401);1rkc_A(0.0336);3s90_A(0.0422);4dj9_A(0.0376);1u6h_A(0.0377);1t01_A(0.0404);3rf3_A(0.0669);3rf3_B(0.0649);3tj5_A(0.0372);2ibf_A(0.0407);3tj6_A(0.0352);1syq_A(0.038);2hsq_A(0.0382);4e18_A(0.0317);1ydi_A(0.036);2gdc_A(0.0365);3zdl_A(0.0364) Cluster-exclusive S:1 0.0317 1 1 brca:1 ENST00000211998 4 3d HLA-DQA1 E51 51 344 2nna_A(0.0523);1uvq_A(0.036);1s9v_D(0.083);3pl6_A(0.0335);1jk8_A(0.0542);1s9v_A(0.0822);4gg6_C(0.0546);4d8p_A(0.0342);4gg6_A(0.052);4grl_A(0.0319);4d8p_C(0.0374);4ozf_A(0.0801);4may_A(0.0348);4ozh_A(0.0708);4ozg_A(0.0726);4ozh_C(0.0675);4ozg_C(0.0688);4ozi_A(0.0694);4ozi_C(0.0809) Cluster-exclusive Q:1|K:2 0.0319 3 2 skcm:2|cesc:1 ENST00000343139 5 3d HLA-DQA1 F52 52 344 2nna_A(0.0523);1uvq_A(0.036);1s9v_D(0.083);3pl6_A(0.0335);1jk8_A(0.0542);1s9v_A(0.0822);4gg6_C(0.0546);4d8p_A(0.0342);4gg6_A(0.052);4grl_A(0.0319);4d8p_C(0.0374);4ozf_A(0.0801);4may_A(0.0348);4ozh_A(0.0708);4ozg_A(0.0726);4ozh_C(0.0675);4ozg_C(0.0688);4ozi_A(0.0694);4ozi_C(0.0809) Cluster-exclusive C:1 0.0319 1 1 ucec:1 ENST00000343139 5 3d HLA-DQA1 D53 53 344 2nna_A(0.0523);1uvq_A(0.036);1s9v_D(0.083);3pl6_A(0.0335);1jk8_A(0.0542);1s9v_A(0.0822);4gg6_C(0.0546);4d8p_A(0.0342);4gg6_A(0.052);4grl_A(0.0319);4d8p_C(0.0374);4ozf_A(0.0801);4may_A(0.0348);4ozh_A(0.0708);4ozg_A(0.0726);4ozh_C(0.0675);4ozg_C(0.0688);4ozi_A(0.0694);4ozi_C(0.0809) Cluster-exclusive H:1 0.0319 1 1 cesc:1 ENST00000343139 5 3d HLA-DQA1 G54 54 344 2nna_A(0.0523);1uvq_A(0.036);1s9v_D(0.083);3pl6_A(0.0335);1jk8_A(0.0542);1s9v_A(0.0822);4gg6_C(0.0546);4d8p_A(0.0342);4gg6_A(0.052);4grl_A(0.0319);4d8p_C(0.0374);4ozf_A(0.0801);4may_A(0.0348);4ozh_A(0.0708);4ozg_A(0.0726);4ozh_C(0.0675);4ozg_C(0.0688);4ozi_A(0.0694);4ozi_C(0.0809) Cluster-exclusive R:2 0.0319 2 1 skcm:2 ENST00000343139 5 3d HLA-DQA1 D55 55 344 2nna_A(0.0523);1uvq_A(0.036);1s9v_D(0.083);3pl6_A(0.0335);1jk8_A(0.0542);1s9v_A(0.0822);4gg6_C(0.0546);4d8p_A(0.0342);4gg6_A(0.052);4grl_A(0.0319);4d8p_C(0.0374);4ozf_A(0.0801);4may_A(0.0348);4ozh_A(0.0708);4ozg_A(0.0726);4ozh_C(0.0675);4ozg_C(0.0688);4ozi_A(0.0694);4ozi_C(0.0809) Cluster-exclusive Y:1 0.0319 1 1 nbl:1 ENST00000343139 5 3d KDM5C D87 87 345 2yqe_A(0.0319) Cluster-exclusive N:1 0.0319 1 1 coadread:1 ENST00000375401 3 3d KDM5C K91 91 345 2yqe_A(0.0319) Cluster-exclusive I:1 0.0319 1 1 luad:1 ENST00000375401 3 3d KDM5C F92 92 345 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 ucec:1 ENST00000375401 3 3d KDM5C W93 93 345 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 kirp:1 ENST00000375401 3 3d KDM5C P163 163 345 2yqe_A(0.0319) Cluster-exclusive S:1 0.0319 1 1 stad:1 ENST00000375401 3 3d KDM5C Q168 168 345 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 lusc:1 ENST00000375401 3 3d KDM5C E158 158 346 2yqe_A(0.0319) Cluster-exclusive K:1 0.0319 1 1 coadread:1 ENST00000375401 3 3d KDM5C R159 159 346 2yqe_A(0.0319) Cluster-exclusive H:1 0.0319 1 1 stad:1 ENST00000375401 3 3d C3 R841 841 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive Q:2 0.0321 2 2 coadread:1|skcm:1 ENST00000245907 6 3d C3 E843 843 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive K:3 0.0321 3 2 stad:1|skcm:2 ENST00000245907 6 3d C3 V932 932 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive M:1 0.0321 1 1 ucec:1 ENST00000245907 6 3d C3 P933 933 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive L:1 0.0321 1 1 skcm:1 ENST00000245907 6 3d C3 E934 934 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive K:1 0.0321 1 1 hnsc:1 ENST00000245907 6 3d C3 G935 935 347 2xwb_B(0.0895);2a74_E(0.0343);2xwb_D(0.0896);2xwj_F(0.0813);3l5n_B(0.0738);2xwj_H(0.0849);2xwj_B(0.0838);2xwj_D(0.0822);2qki_E(0.0321) Cluster-exclusive R:2|E:1 0.0321 3 2 skcm:2|cscc:1 ENST00000245907 6 3d CDK8 S60 60 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive P:1|C:1 0.0321 2 2 kirc:1|luad:1 ENST00000381527 3 3d CDK8 S62 62 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive L:1 0.0321 1 1 gbm:1 ENST00000381527 3 3d CDK8 A63 63 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive T:1 0.0321 1 1 blca:1 ENST00000381527 3 3d CDK8 R65 65 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive K:1 0.0321 1 1 hnsc:1 ENST00000381527 3 3d CDK8 E66 66 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive Q:1 0.0321 1 1 hnsc:1 ENST00000381527 3 3d CDK8 V93 93 348 4f6w_A(0.0379);4f7l_A(0.0351);4f7n_A(0.0321) Cluster-exclusive L:2|M:1 0.0321 3 2 all:1|skcm:2 ENST00000381527 3 3d SSBP1 G37 37 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive W:1 0.0321 1 1 luad:1 ENST00000265304 6 3d SSBP1 R38 38 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive Q:1 0.0321 1 1 stad:1 ENST00000265304 6 3d SSBP1 V39 39 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive L:1 0.0321 1 1 skcm:1 ENST00000265304 6 3d SSBP1 S58 58 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive A:1 0.0321 1 1 coadread:1 ENST00000265304 6 3d SSBP1 W84 84 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive R:1 0.0321 1 1 coadread:1 ENST00000265304 6 3d SSBP1 R107 107 349 1s3o_A(0.0321);3ull_A(0.0332) Cluster-exclusive Q:3 0.0321 3 3 brca:1|coadread:1|ucec:1 ENST00000265304 6 3d SNRNP200 R840 840 350 3lu8_A(0.0323) Cluster-exclusive C:1 0.0323 1 1 ucec:1 ENST00000323853 5 3d SNRNP200 G845 845 350 3lu8_A(0.0323) Cluster-exclusive R:1 0.0323 1 1 skcm:1 ENST00000323853 5 3d SNRNP200 A846 846 350 3lu8_A(0.0323) Cluster-exclusive S:1 0.0323 1 1 ucec:1 ENST00000323853 5 3d SNRNP200 D848 848 350 3lu8_A(0.0323) Cluster-exclusive G:1 0.0323 1 1 skcm:1 ENST00000323853 5 3d SNRNP200 H873 873 350 3lu8_A(0.0323) Cluster-exclusive Y:1 0.0323 1 1 blca:1 ENST00000323853 5 3d SNRNP200 G874 874 350 3lu8_A(0.0323) Cluster-exclusive W:1 0.0323 1 1 skcm:1 ENST00000323853 5 3d H4C13 D69 69 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive H:1|N:1 0.0328 2 2 blca:1|luad:1 ENST00000355981 2 3d H4C13 T72 72 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive A:1 0.0328 1 1 stad:1 ENST00000355981 2 3d NRAS D33 33 354 1aa9_A(0.033) Hotspot-linked H:1 0.033 1 1 ucec:1 ENST00000369535 4 3d SDC3 S82 82 356 3mv7_A(0.0331) Cluster-exclusive L:1 0.0331 1 1 skcm:1 ENST00000339394 6 3d SDC3 S84 84 356 3mv7_A(0.0331) Cluster-exclusive L:1 0.0331 1 1 coadread:1 ENST00000339394 6 3d SDC3 S131 131 356 3mv7_A(0.0331) Cluster-exclusive C:1 0.0331 1 1 luad:1 ENST00000339394 6 3d SDC3 R133 133 356 3mv7_A(0.0331) Cluster-exclusive H:1 0.0331 1 1 ucec:1 ENST00000339394 6 3d SDC3 A139 139 356 3mv7_A(0.0331) Cluster-exclusive V:1 0.0331 1 1 stad:1 ENST00000339394 6 3d NCS1 D73 73 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive H:1 0.0333 1 1 hnsc:1 ENST00000372398 3 3d NCS1 R79 79 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive Q:1 0.0333 1 1 coadread:1 ENST00000372398 3 3d NCS1 F82 82 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive L:1 0.0333 1 1 coadread:1 ENST00000372398 3 3d NCS1 E84 84 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive K:1 0.0333 1 1 coadread:1 ENST00000372398 3 3d NCS1 Q87 87 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive H:1 0.0333 1 1 luad:1 ENST00000372398 3 3d NCS1 A88 88 359 4guk_D(0.0333);4guk_B(0.0351);4guk_C(0.0385);4guk_A(0.0341);1g8i_B(0.0345);1g8i_A(0.034);2lcp_A(0.0469) Cluster-exclusive V:2 0.0333 2 2 coadread:1|stad:1 ENST00000372398 3 3d PBRM1 R522 522 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive L:1 0.0334 1 1 luad:1 ENST00000394830 3 3d PBRM1 E583 583 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive K:1 0.0334 1 1 blca:1 ENST00000394830 3 3d PBRM1 L618 618 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive H:1 0.0334 1 1 kirc:1 ENST00000394830 3 3d PBRM1 E620 620 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive Q:1 0.0334 1 1 luad:1 ENST00000394830 3 3d PBRM1 R622 622 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive G:1 0.0334 1 1 esca:1 ENST00000394830 3 3d PBRM1 K623 623 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive R:1 0.0334 1 1 luad:1 ENST00000394830 3 3d PBRM1 G626 626 360 3tlp_B(0.0402);3tlp_A(0.0334) Cluster-exclusive V:1 0.0334 1 1 kirc:1 ENST00000394830 3 3d SMAD4 P91 91 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive S:1 0.0335 1 1 skcm:1 ENST00000342988 3 3d SMAD4 R97 97 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive C:1|H:2 0.0335 3 3 coadread:1|hnsc:1|ucec:1 ENST00000342988 3 3d DPYSL3 G330 330 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive W:1 0.0336 1 1 kirp:1 ENST00000398514 3 3d DPYSL3 E359 359 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive V:1 0.0336 1 1 luad:1 ENST00000398514 3 3d DPYSL3 E360 360 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive D:1 0.0336 1 1 kirc:1 ENST00000398514 3 3d MCF2 E313 313 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive D:1 0.0338 1 1 hnsc:1 ENST00000370576 4 3d MCF2 K315 315 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive E:1 0.0338 1 1 mmyl:1 ENST00000370576 4 3d MCF2 E367 367 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive K:1 0.0338 1 1 skcm:1 ENST00000370576 4 3d MCF2 N368 368 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive H:1 0.0338 1 1 ucec:1 ENST00000370576 4 3d MCF2 L370 370 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive I:1 0.0338 1 1 ucec:1 ENST00000370576 4 3d MCF2 E371 371 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive K:1 0.0338 1 1 stad:1 ENST00000370576 4 3d MCF2 A373 373 364 2nmp_C(0.0614);2nmp_B(0.0526);3elp_A(0.0338);2nmp_A(0.0622);3cog_C(0.0601);3cog_D(0.0613);3cog_A(0.0541);3cog_B(0.0553);2nmp_D(0.0579) Cluster-exclusive S:1 0.0338 1 1 luad:1 ENST00000370576 4 3d EEF1G R353 353 365 1pbu_A(0.034) Cluster-exclusive M:1 0.034 1 1 paad:1 ENST00000329251 4 3d EEF1G K354 354 365 1pbu_A(0.034) Cluster-exclusive N:1 0.034 1 1 blca:1 ENST00000329251 4 3d EEF1G F436 436 365 1pbu_A(0.034) Cluster-exclusive S:1 0.034 1 1 stad:1 ENST00000329251 4 3d EEF1G K437 437 365 1pbu_A(0.034) Cluster-exclusive E:1 0.034 1 1 skcm:1 ENST00000329251 4 3d DDC L122 122 366 3rbl_A(0.0347);3rch_A(0.036);3rbf_B(0.0344);3rbf_A(0.0341) Cluster-exclusive R:1|F:1 0.0341 2 2 cscc:1|luad:1 ENST00000357936 5 3d DDC G123 123 366 3rbl_A(0.0347);3rch_A(0.036);3rbf_B(0.0344);3rbf_A(0.0341) Cluster-exclusive R:1|W:1 0.0341 2 2 cscc:1|kirp:1 ENST00000357936 5 3d DDC M125 125 366 3rbl_A(0.0347);3rch_A(0.036);3rbf_B(0.0344);3rbf_A(0.0341) Cluster-exclusive L:1 0.0341 1 1 ov:1 ENST00000357936 5 3d DDC E127 127 366 3rbl_A(0.0347);3rch_A(0.036);3rbf_B(0.0344);3rbf_A(0.0341) Cluster-exclusive A:1|K:1 0.0341 2 2 hnsc:1|lusc:1 ENST00000357936 5 3d DDC L133 133 366 3rbl_A(0.0347);3rch_A(0.036);3rbf_B(0.0344);3rbf_A(0.0341) Cluster-exclusive S:1|F:1 0.0341 2 2 hnsc:1|cscc:1 ENST00000357936 5 3d ZNF484 E696 696 367 2ytp_A(0.0341) Cluster-exclusive K:1 0.0341 1 1 cesc:1 ENST00000375495 3 3d ZNF484 Q711 711 367 2ytp_A(0.0341) Cluster-exclusive E:1 0.0341 1 1 brca:1 ENST00000375495 3 3d ZNF484 R712 712 367 2ytp_A(0.0341) Cluster-exclusive I:2 0.0341 2 1 ucec:2 ENST00000375495 3 3d ZNF484 H714 714 367 2ytp_A(0.0341) Cluster-exclusive N:1 0.0341 1 1 ucec:1 ENST00000375495 3 3d ZNF484 T715 715 367 2ytp_A(0.0341) Cluster-exclusive A:1 0.0341 1 1 brca:1 ENST00000375495 3 3d CABP1 R328 328 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive Q:1 0.0344 1 1 luad:1 ENST00000316803 3 3d CABP1 E329 329 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive Q:1 0.0344 1 1 gbm:1 ENST00000316803 3 3d CABP1 A330 330 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive D:1 0.0344 1 1 lihc:1 ENST00000316803 3 3d CABP1 M331 331 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive I:1 0.0344 1 1 luad:1 ENST00000316803 3 3d CABP1 G340 340 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive R:1 0.0344 1 1 skcm:1 ENST00000316803 3 3d CABP1 H341 341 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive Q:1 0.0344 1 1 skcm:1 ENST00000316803 3 3d CABP1 I344 344 369 3ox5_A(0.0378);3ox6_D(0.0344);3ox5_B(0.0357);3ox5_C(0.0394);3ox6_B(0.0381) Cluster-exclusive M:1 0.0344 1 1 luad:1 ENST00000316803 3 3d TOPBP1 L168 168 371 2xnk_A(0.0348);2xnk_C(0.0423);2xnk_D(0.0404) Cluster-exclusive I:1 0.0348 1 1 paad:1 ENST00000260810 5 3d TOPBP1 C197 197 371 2xnk_A(0.0348);2xnk_C(0.0423);2xnk_D(0.0404) Cluster-exclusive Y:1 0.0348 1 1 skcm:1 ENST00000260810 5 3d TOPBP1 L201 201 371 2xnk_A(0.0348);2xnk_C(0.0423);2xnk_D(0.0404) Cluster-exclusive F:1|V:1 0.0348 2 2 stad:1|gbm:1 ENST00000260810 5 3d TOPBP1 G202 202 371 2xnk_A(0.0348);2xnk_C(0.0423);2xnk_D(0.0404) Cluster-exclusive R:1 0.0348 1 1 cll:1 ENST00000260810 5 3d TOPBP1 H225 225 371 2xnk_A(0.0348);2xnk_C(0.0423);2xnk_D(0.0404) Cluster-exclusive R:1 0.0348 1 1 brca:1 ENST00000260810 5 3d DOT1L L111 111 373 4wvl_A(0.035) Cluster-exclusive M:1 0.035 1 1 stad:1 ENST00000398665 3 3d DOT1L Y115 115 373 4wvl_A(0.035) Cluster-exclusive N:1 0.035 1 1 blca:1 ENST00000398665 3 3d DOT1L S118 118 373 4wvl_A(0.035) Cluster-exclusive L:1 0.035 1 1 stad:1 ENST00000398665 3 3d DOT1L V119 119 373 4wvl_A(0.035) Cluster-exclusive L:1 0.035 1 1 mbl:1 ENST00000398665 3 3d DOT1L P122 122 373 4wvl_A(0.035) Cluster-exclusive R:1 0.035 1 1 kirp:1 ENST00000398665 3 3d DOT1L G137 137 373 4wvl_A(0.035) Cluster-exclusive R:1 0.035 1 1 coadread:1 ENST00000398665 3 3d VCL N217 217 375 3rf3_A(0.0669);3rf3_B(0.0649);3tj6_A(0.0352);2ibf_A(0.0407);2hsq_A(0.0382);1ydi_A(0.036);2gdc_A(0.0365);1rke_A(0.0404);3zdl_A(0.0364);1xwj_A(0.0368);1zw3_A(0.0373);3s90_A(0.0422) Cluster-exclusive S:1 0.0352 1 1 ucec:1 ENST00000211998 4 3d MTOR A1459 1459 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked P:1 0.0353 1 1 kirc:1 ENST00000361445 4 3d MTOR L1460 1460 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked P:2 0.0353 2 1 kirc:2 ENST00000361445 4 3d MTOR V1461 1461 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked L:1 0.0353 1 1 ov:1 ENST00000361445 4 3d MTOR Y1463 1463 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked S:1 0.0353 1 1 kirc:1 ENST00000361445 4 3d MTOR K1465 1465 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked N:1 0.0353 1 1 luad:1 ENST00000361445 4 3d MTOR M1467 1467 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked I:1 0.0353 1 1 cesc:1 ENST00000361445 4 3d MTOR R1480 1480 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot-linked H:2 0.0353 2 2 paad:1|coadread:1 ENST00000361445 4 3d MTOR C1483 1483 376 4jsp_B(0.0358);4jsp_A(0.0357);4jsn_B(0.0402);4jsn_A(0.0378);4jsx_B(0.0366);4jsx_A(0.036);4jsv_B(0.04);4jsv_A(0.0402);4jt6_B(0.0383);4jt5_B(0.0353);4jt6_A(0.0381);4jt5_A(0.0359) Hotspot R:1|F:2|W:1|Y:1 0.0353 5 3 brca:1|gbm:1|kirc:3 ENST00000361445 4 3d AOC1 R141 141 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive G:1 0.0353 1 1 stad:1 ENST00000360937 4 3d AOC1 R190 190 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive Q:2 0.0353 2 1 esca:2 ENST00000360937 4 3d AOC1 R197 197 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive C:1|H:1 0.0353 2 2 coadread:1|gbm:1 ENST00000360937 4 3d AOC1 H639 639 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive Y:1 0.0353 1 1 stad:1 ENST00000360937 4 3d AOC1 N641 641 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive S:1 0.0353 1 1 coadread:1 ENST00000360937 4 3d AOC1 D642 642 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive N:3 0.0353 3 2 brca:1|skcm:2 ENST00000360937 4 3d AOC1 W644 644 377 3hig_A(0.0381);3hi7_A(0.0401);3hii_A(0.0385);3hi7_B(0.0353);3hig_B(0.038);3hii_B(0.0423);3k5t_A(0.045);3mph_B(0.0391);3mph_A(0.0388) Cluster-exclusive L:1 0.0353 1 1 luad:1 ENST00000360937 4 3d ITGA1 S329 329 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive L:1 0.0358 1 1 skcm:1 ENST00000282588 6 3d PTPRR M402 402 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive I:2 0.0359 2 2 skcm:1|cscc:1 ENST00000283228 2 3d PTPRR P426 426 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive L:1 0.0359 1 1 skcm:1 ENST00000283228 2 3d PTPRR N427 427 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive H:1 0.0359 1 1 stad:1 ENST00000283228 2 3d PTPRR I452 452 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive S:1 0.0359 1 1 lihc:1 ENST00000283228 2 3d PTPRR T465 465 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive M:1 0.0359 1 1 gbm:1 ENST00000283228 2 3d PTPRR L623 623 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive I:1 0.0359 1 1 lusc:1 ENST00000283228 2 3d PTPRR R624 624 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive C:2|S:1 0.0359 3 3 coadread:1|skcm:1|luad:1 ENST00000283228 2 3d PTPRR D626 626 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive N:1 0.0359 1 1 skcm:1 ENST00000283228 2 3d PTPRR R627 627 379 1jln_A(0.0359);2a8b_A(0.0518) Cluster-exclusive K:1 0.0359 1 1 ucec:1 ENST00000283228 2 3d PRKCB V18 18 380 4gab_A(0.0478);4jih_A(0.0359);1zua_X(0.0504);4i5x_A(0.0387);4gqg_A(0.0427);4ga8_A(0.0475);4jii_X(0.0408);4gq0_A(0.0494) Cluster-exclusive M:1 0.0359 1 1 skcm:1 ENST00000321728 7 3d PRKCB R19 19 380 4gab_A(0.0478);4jih_A(0.0359);1zua_X(0.0504);4i5x_A(0.0387);4gqg_A(0.0427);4ga8_A(0.0475);4jii_X(0.0408);4gq0_A(0.0494) Cluster-exclusive C:1|L:1 0.0359 2 2 paad:1|luad:1 ENST00000321728 7 3d PRKCB F20 20 380 4gab_A(0.0478);4jih_A(0.0359);1zua_X(0.0504);4i5x_A(0.0387);4gqg_A(0.0427);4ga8_A(0.0475);4jii_X(0.0408);4gq0_A(0.0494) Cluster-exclusive S:1 0.0359 1 1 hnsc:1 ENST00000321728 7 3d PRKCB A21 21 380 4gab_A(0.0478);4jih_A(0.0359);1zua_X(0.0504);4i5x_A(0.0387);4gqg_A(0.0427);4ga8_A(0.0475);4jii_X(0.0408);4gq0_A(0.0494) Cluster-exclusive S:1|T:1 0.0359 2 2 acc:1|stad:1 ENST00000321728 7 3d PRKCB R22 22 380 4gab_A(0.0478);4jih_A(0.0359);1zua_X(0.0504);4i5x_A(0.0387);4gqg_A(0.0427);4ga8_A(0.0475);4jii_X(0.0408);4gq0_A(0.0494) Cluster-exclusive H:1 0.0359 1 1 paad:1 ENST00000321728 7 3d LHX6 E116 116 381 1crr_A(0.0362);1crp_A(0.0378);2lwi_A(0.0509);2lcf_A(0.0426) Cluster-exclusive D:1 0.0362 1 1 ucec:1 ENST00000373755 2 3d LHX6 S141 141 381 1crr_A(0.0362);1crp_A(0.0378);2lwi_A(0.0509);2lcf_A(0.0426) Cluster-exclusive N:1 0.0362 1 1 coadread:1 ENST00000373755 2 3d LHX6 D142 142 381 1crr_A(0.0362);1crp_A(0.0378);2lwi_A(0.0509);2lcf_A(0.0426) Cluster-exclusive Y:1|N:1 0.0362 2 2 acc:1|skcm:1 ENST00000373755 2 3d LHX6 R145 145 381 1crr_A(0.0362);1crp_A(0.0378);2lwi_A(0.0509);2lcf_A(0.0426) Cluster-exclusive W:2 0.0362 2 2 coadread:1|gbm:1 ENST00000373755 2 3d LHX6 R146 146 381 1crr_A(0.0362);1crp_A(0.0378);2lwi_A(0.0509);2lcf_A(0.0426) Cluster-exclusive K:1 0.0362 1 1 cscc:1 ENST00000373755 2 3d KCNA3 E127 127 383 4bgc_A(0.0363) Cluster-exclusive K:2 0.0363 2 2 stad:1|hnsc:1 ENST00000369769 2 3d KCNA3 T128 128 383 4bgc_A(0.0363) Cluster-exclusive M:3 0.0363 3 2 coadread:1|stad:2 ENST00000369769 2 3d KCNA3 R135 135 383 4bgc_A(0.0363) Cluster-exclusive W:1 0.0363 1 1 cesc:1 ENST00000369769 2 3d KCNA3 R136 136 383 4bgc_A(0.0363) Cluster-exclusive C:2|H:1 0.0363 3 3 coadread:1|stad:1|ucec:1 ENST00000369769 2 3d KCNA3 Y139 139 383 4bgc_A(0.0363) Cluster-exclusive C:1 0.0363 1 1 ucs:1 ENST00000369769 2 3d PLK2 K95 95 385 4i5m_A(0.0364);4i6h_A(0.0443);4i6f_A(0.0487);4i6b_A(0.0491);4i5p_A(0.0431) Cluster-exclusive T:1 0.0364 1 1 ucec:1 ENST00000274289 3 3d PLK2 E98 98 385 4i5m_A(0.0364);4i6h_A(0.0443);4i6f_A(0.0487);4i6b_A(0.0491);4i5p_A(0.0431) Cluster-exclusive Q:1 0.0364 1 1 cscc:1 ENST00000274289 3 3d PLK2 M99 99 385 4i5m_A(0.0364);4i6h_A(0.0443);4i6f_A(0.0487);4i6b_A(0.0491);4i5p_A(0.0431) Cluster-exclusive T:1|I:1 0.0364 2 2 stad:1|hnsc:1 ENST00000274289 3 3d PLK2 A110 110 385 4i5m_A(0.0364);4i6h_A(0.0443);4i6f_A(0.0487);4i6b_A(0.0491);4i5p_A(0.0431) Cluster-exclusive T:2 0.0364 2 2 prad:1|gbm:1 ENST00000274289 3 3d PLK2 I157 157 385 4i5m_A(0.0364);4i6h_A(0.0443);4i6f_A(0.0487);4i6b_A(0.0491);4i5p_A(0.0431) Cluster-exclusive V:1 0.0364 1 1 ov:1 ENST00000274289 3 3d SH3GLB2 R45 45 386 4mpf_A(0.0431);4mpg_A(0.0413);2ljr_A(0.0492);4mpg_B(0.0364);1ljr_A(0.048);3ljr_A(0.0476) Cluster-exclusive Q:2 0.0364 2 2 stad:1|ucec:1 ENST00000372559 1 3d SH3GLB2 K50 50 386 4mpf_A(0.0431);4mpg_A(0.0413);2ljr_A(0.0492);4mpg_B(0.0364);1ljr_A(0.048);3ljr_A(0.0476) Cluster-exclusive N:1 0.0364 1 1 brca:1 ENST00000372559 1 3d SH3GLB2 E54 54 386 4mpf_A(0.0431);4mpg_A(0.0413);2ljr_A(0.0492);4mpg_B(0.0364);1ljr_A(0.048);3ljr_A(0.0476) Cluster-exclusive G:1 0.0364 1 1 lihc:1 ENST00000372559 1 3d SH3GLB2 K55 55 386 4mpf_A(0.0431);4mpg_A(0.0413);2ljr_A(0.0492);4mpg_B(0.0364);1ljr_A(0.048);3ljr_A(0.0476) Cluster-exclusive N:1 0.0364 1 1 coadread:1 ENST00000372559 1 3d CAMK1 T114 114 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive M:2 0.0365 2 1 coadread:2 ENST00000256460 3 3d CAMK1 E115 115 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive K:1 0.0365 1 1 skcm:1 ENST00000256460 3 3d CAMK1 R120 120 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive H:1 0.0365 1 1 paad:1 ENST00000256460 3 3d CAMK1 L212 212 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive P:1 0.0365 1 1 stad:1 ENST00000256460 3 3d CAMK1 S246 246 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive C:1 0.0365 1 1 cesc:1 ENST00000256460 3 3d CAMK1 I286 286 387 4fgb_A(0.0576);4fg9_B(0.0365);4fg8_B(0.0422);4fg9_A(0.0365) Cluster-exclusive V:1 0.0365 1 1 kirp:1 ENST00000256460 3 3d SMG7 L361 361 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive F:1 0.0367 1 1 cscc:1 ENST00000347615 2 3d SMG7 K365 365 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive N:1 0.0367 1 1 luad:1 ENST00000347615 2 3d SMG7 L415 415 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive P:1 0.0367 1 1 lihc:1 ENST00000347615 2 3d SMG7 E417 417 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive Q:1 0.0367 1 1 hnsc:1 ENST00000347615 2 3d SMG7 I454 454 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive K:1 0.0367 1 1 hnsc:1 ENST00000347615 2 3d SMG7 R455 455 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive Q:1 0.0367 1 1 coadread:1 ENST00000347615 2 3d SMG7 R458 458 389 1ya0_B(0.0399);1ya0_A(0.0367) Cluster-exclusive H:2 0.0367 2 2 coadread:1|stad:1 ENST00000347615 2 3d PIWIL2 R425 425 390 3o7x_A(0.0409);3qir_A(0.0367);3qir_D(0.0578);3o7x_D(0.0388);3o7x_C(0.042) Cluster-exclusive C:1|H:1 0.0367 2 1 coadread:2 ENST00000356766 6 3d PIWIL2 T426 426 390 3o7x_A(0.0409);3qir_A(0.0367);3qir_D(0.0578);3o7x_D(0.0388);3o7x_C(0.042) Cluster-exclusive P:1 0.0367 1 1 luad:1 ENST00000356766 6 3d PIWIL2 Y427 427 390 3o7x_A(0.0409);3qir_A(0.0367);3qir_D(0.0578);3o7x_D(0.0388);3o7x_C(0.042) Cluster-exclusive D:1 0.0367 1 1 cscc:1 ENST00000356766 6 3d PIWIL2 R428 428 390 3o7x_A(0.0409);3qir_A(0.0367);3qir_D(0.0578);3o7x_D(0.0388);3o7x_C(0.042) Cluster-exclusive C:2|H:1 0.0367 3 2 skcm:2|ucec:1 ENST00000356766 6 3d SMAD4 A39 39 391 3qsv_A(0.0368) Cluster-exclusive G:1 0.0368 1 1 paad:1 ENST00000342988 3 3d TRPV1 A209 209 393 3j5q_B(0.0397);3j5r_A(0.037);3j5p_A(0.0415);2wa0_A(0.0506) Cluster-exclusive T:2 0.037 2 2 coadread:1|ucec:1 ENST00000399756 4 3d TRPV1 R212 212 393 3j5q_B(0.0397);3j5r_A(0.037);3j5p_A(0.0415);2wa0_A(0.0506) Cluster-exclusive K:1 0.037 1 1 brca:1 ENST00000399756 4 3d TRPV1 R213 213 393 3j5q_B(0.0397);3j5r_A(0.037);3j5p_A(0.0415);2wa0_A(0.0506) Cluster-exclusive H:2 0.037 2 2 coadread:1|stad:1 ENST00000399756 4 3d TRPV1 M215 215 393 3j5q_B(0.0397);3j5r_A(0.037);3j5p_A(0.0415);2wa0_A(0.0506) Cluster-exclusive I:1 0.037 1 1 luad:1 ENST00000399756 4 3d ATXN1 T614 614 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive I:1 0.0371 1 1 paad:1 ENST00000244769 4 3d ATXN1 V633 633 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive I:1 0.0371 1 1 brca:1 ENST00000244769 4 3d ATXN1 G634 634 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive W:1 0.0371 1 1 kirp:1 ENST00000244769 4 3d ATXN1 E635 635 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive G:1 0.0371 1 1 skcm:1 ENST00000244769 4 3d ATXN1 Q639 639 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive H:1 0.0371 1 1 lihc:1 ENST00000244769 4 3d ATXN1 V640 640 394 1oa8_A(0.0499);4j2l_B(0.0628);1oa8_D(0.0371) Cluster-exclusive G:1 0.0371 1 1 gbm:1 ENST00000244769 4 3d LILRB2 P35 35 395 1p7q_D(0.0372) Cluster-exclusive S:1 0.0372 1 1 skcm:1 ENST00000618705 3d LILRB2 G42 42 395 1p7q_D(0.0372) Cluster-exclusive V:1 0.0372 1 1 luad:1 ENST00000618705 3d LILRB2 S43 43 395 1p7q_D(0.0372) Cluster-exclusive C:1 0.0372 1 1 lusc:1 ENST00000618705 3d LILRB2 P44 44 395 1p7q_D(0.0372) Cluster-exclusive T:1 0.0372 1 1 luad:1 ENST00000618705 3d LILRB2 V45 45 395 1p7q_D(0.0372) Cluster-exclusive I:1 0.0372 1 1 coadread:1 ENST00000618705 3d ACVR1B A401 401 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive T:1 0.0374 1 1 paad:1 ENST00000257963 4 3d ACVR1B D402 402 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive E:1 0.0374 1 1 paad:1 ENST00000257963 4 3d ACVR1B Y404 404 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive C:1 0.0374 1 1 stad:1 ENST00000257963 4 3d ACVR1B A405 405 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive V:2 0.0374 2 2 ucec:1|lusc:1 ENST00000257963 4 3d ACVR1B G407 407 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive R:1 0.0374 1 1 coadread:1 ENST00000257963 4 3d ACVR1B C476 476 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive F:1|Y:1 0.0374 2 2 brca:1|ucs:1 ENST00000257963 4 3d ACVR1B R484 484 396 1py5_A(0.0449);3tzm_A(0.0431);3faa_C(0.0375);3kcf_C(0.0391);2x7o_A(0.0374);1b6c_B(0.0457);1ias_A(0.0412);1rw8_A(0.0477);2wou_A(0.0479);2wot_A(0.0462) Cluster-exclusive H:2|L:1 0.0374 3 2 stad:2|ucec:1 ENST00000257963 4 3d GNAI3 Y74 74 397 4g5o_C(0.0381);4g5o_B(0.0475);4g5o_D(0.0468);4g5r_A(0.0415);4g5r_D(0.0375);2v4z_A(0.0554);4g5s_D(0.0397);2ihb_A(0.052);2ode_A(0.0594);4g5o_A(0.0478);2ode_C(0.0529) Cluster-exclusive C:1 0.0375 1 1 stad:1 ENST00000369851 4 3d GNAI3 M119 119 397 4g5o_C(0.0381);4g5o_B(0.0475);4g5o_D(0.0468);4g5r_A(0.0415);4g5r_D(0.0375);2v4z_A(0.0554);4g5s_D(0.0397);2ihb_A(0.052);2ode_A(0.0594);4g5o_A(0.0478);2ode_C(0.0529) Cluster-exclusive T:1 0.0375 1 1 brca:1 ENST00000369851 4 3d GNAI3 R161 161 397 4g5o_C(0.0381);4g5o_B(0.0475);4g5o_D(0.0468);4g5r_A(0.0415);4g5r_D(0.0375);2v4z_A(0.0554);4g5s_D(0.0397);2ihb_A(0.052);2ode_A(0.0594);4g5o_A(0.0478);2ode_C(0.0529) Cluster-exclusive K:1 0.0375 1 1 cesc:1 ENST00000369851 4 3d GNAI3 S163 163 397 4g5o_C(0.0381);4g5o_B(0.0475);4g5o_D(0.0468);4g5r_A(0.0415);4g5r_D(0.0375);2v4z_A(0.0554);4g5s_D(0.0397);2ihb_A(0.052);2ode_A(0.0594);4g5o_A(0.0478);2ode_C(0.0529) Cluster-exclusive A:1|F:1 0.0375 2 2 skcm:1|kirp:1 ENST00000369851 4 3d GNAI3 Q164 164 397 4g5o_C(0.0381);4g5o_B(0.0475);4g5o_D(0.0468);4g5r_A(0.0415);4g5r_D(0.0375);2v4z_A(0.0554);4g5s_D(0.0397);2ihb_A(0.052);2ode_A(0.0594);4g5o_A(0.0478);2ode_C(0.0529) Cluster-exclusive P:1|H:1 0.0375 2 2 ov:1|ucec:1 ENST00000369851 4 3d GNAI3 V118 118 398 4g5r_D(0.0375) Cluster-exclusive I:1 0.0375 1 1 ucs:1 ENST00000369851 4 3d RB1 Q702 702 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive K:1 0.0378 1 1 ov:1 ENST00000267163 4 3d RB1 I703 703 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive F:1 0.0378 1 1 coadread:1 ENST00000267163 4 3d RB1 S751 751 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive Y:1 0.0378 1 1 ucec:1 ENST00000267163 4 3d RB1 F755 755 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive I:1 0.0378 1 1 ucec:1 ENST00000267163 4 3d RB1 Y756 756 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive C:1 0.0378 1 1 luad:1 ENST00000267163 4 3d RB1 S758 758 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive L:1 0.0378 1 1 ucec:1 ENST00000267163 4 3d RB1 M761 761 400 2r7g_A(0.0399);2r7g_C(0.0434);3pom_A(0.0465);4ell_B(0.0488);3pom_B(0.0397);1n4m_A(0.0526);4elj_A(0.0503);1n4m_B(0.0487);4ell_A(0.0432);1gh6_B(0.0378) Cluster-exclusive L:1 0.0378 1 1 blca:1 ENST00000267163 4 3d FBXW7 A503 503 402 2ovr_B(0.0388);2ovq_B(0.038);2ovp_B(0.0495) Hotspot-linked V:1 0.038 1 1 stad:1 ENST00000281708 4 3d FBXW7 G517 517 402 2ovr_B(0.0388);2ovq_B(0.038);2ovp_B(0.0495) Hotspot-linked E:1 0.038 1 1 lusc:1 ENST00000281708 4 3d FBXW7 Y545 545 402 2ovr_B(0.0388);2ovq_B(0.038);2ovp_B(0.0495) Hotspot-linked C:3 0.038 3 3 brca:1|hnsc:1|ucec:1 ENST00000281708 4 3d ITGA4 S426 426 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive L:5 0.0381 5 2 coadread:1|skcm:4 ENST00000397033 2 3d MASP2 A305 305 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive P:1 0.0381 1 1 ov:1 ENST00000400897 3 3d MASP2 P306 306 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive S:1 0.0381 1 1 skcm:1 ENST00000400897 3 3d MASP2 N308 308 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive T:2 0.0381 2 2 brca:1|blca:1 ENST00000400897 3 3d MASP2 H310 310 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive Q:1 0.0381 1 1 cscc:1 ENST00000400897 3 3d MASP2 S312 312 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive L:1 0.0381 1 1 skcm:1 ENST00000400897 3 3d MASP2 P313 313 404 1ppj_B(0.0487);1sqq_B(0.0451);1sqp_B(0.047);2ybb_B(0.0503);1ntz_B(0.052);2a06_B(0.0516);1sqx_B(0.0536);1sqv_B(0.0484);1pp9_B(0.0502);1sqb_B(0.0561);1be3_B(0.0381);1bgy_B(0.0424);1ntk_B(0.05);1ntm_B(0.0488);1l0n_B(0.0482);2fyu_B(0.0541);1l0l_B(0.0493);1nu1_B(0.0449) Cluster-exclusive H:1 0.0381 1 1 coadread:1 ENST00000400897 3 3d KEAP1 R415 415 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive C:1|H:1 0.0383 2 1 luad:2 ENST00000171111 5 3d KEAP1 G429 429 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive S:1|V:1 0.0383 2 2 hnsc:1|luad:1 ENST00000171111 5 3d KEAP1 G430 430 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive V:1 0.0383 1 1 luad:1 ENST00000171111 5 3d KEAP1 R459 459 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive Q:1 0.0383 1 1 skcm:1 ENST00000171111 5 3d KEAP1 R460 460 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive G:1 0.0383 1 1 luad:1 ENST00000171111 5 3d KEAP1 I461 461 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive V:1 0.0383 1 1 luad:1 ENST00000171111 5 3d KEAP1 V475 475 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive L:1 0.0383 1 1 skcm:1 ENST00000171111 5 3d KEAP1 G476 476 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive V:1 0.0383 1 1 luad:1 ENST00000171111 5 3d KEAP1 G477 477 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive S:1 0.0383 1 1 thca:1 ENST00000171111 5 3d KEAP1 D479 479 405 1u6d_X(0.0601);4ifn_X(0.0561);3vnh_A(0.0624);3vng_A(0.0566);3zgd_A(0.0709);4ifj_A(0.0593);2z32_A(0.0555);3wn7_A(0.0559);4in4_C(0.0596);3zgd_B(0.0665);1zgk_A(0.0565);4in4_A(0.065);4n1b_A(0.0454);4n1b_B(0.0383);4l7d_A(0.0584);2flu_X(0.0615);1x2r_A(0.0554);3wdz_A(0.0468) Cluster-exclusive G:1 0.0383 1 1 luad:1 ENST00000171111 5 3d TBL1XR1 D370 370 406 1rg6_A(0.0384) Cluster-exclusive N:1 0.0384 1 1 coadread:1 ENST00000430069 1 3d TBL1XR1 K374 374 406 1rg6_A(0.0384) Cluster-exclusive N:2 0.0384 2 2 stad:1|luad:1 ENST00000430069 1 3d TBL1XR1 I375 375 406 1rg6_A(0.0384) Cluster-exclusive K:1 0.0384 1 1 hnsc:1 ENST00000430069 1 3d TBL1XR1 W376 376 406 1rg6_A(0.0384) Cluster-exclusive L:1 0.0384 1 1 blca:1 ENST00000430069 1 3d TBL1XR1 N382 382 406 1rg6_A(0.0384) Cluster-exclusive S:1 0.0384 1 1 brca:1 ENST00000430069 1 3d TBL1XR1 Y395 395 406 1rg6_A(0.0384) Cluster-exclusive H:1 0.0384 1 1 coadread:1 ENST00000430069 1 3d TBL1XR1 T396 396 406 1rg6_A(0.0384) Cluster-exclusive A:1 0.0384 1 1 coadread:1 ENST00000430069 1 3d APLP1 R605 605 409 2v5p_A(0.0387) Cluster-exclusive S:1 0.0387 1 1 blca:1 ENST00000221891 4 3d APLP1 R606 606 409 2v5p_A(0.0387) Cluster-exclusive K:1 0.0387 1 1 cscc:1 ENST00000221891 4 3d APLP1 K607 607 409 2v5p_A(0.0387) Cluster-exclusive T:1 0.0387 1 1 skcm:1 ENST00000221891 4 3d APLP1 R632 632 409 2v5p_A(0.0387) Cluster-exclusive H:2 0.0387 2 2 stad:1|ucec:1 ENST00000221891 4 3d APLP1 E633 633 409 2v5p_A(0.0387) Cluster-exclusive K:2 0.0387 2 2 skcm:1|cscc:1 ENST00000221891 4 3d APLP1 Q635 635 409 2v5p_A(0.0387) Cluster-exclusive R:1 0.0387 1 1 stad:1 ENST00000221891 4 3d APLP1 K608 608 410 2v5p_A(0.0387) Cluster-exclusive N:1 0.0387 1 1 hnsc:1 ENST00000221891 4 3d TIGD1 F57 57 412 3oxu_A(0.0534);3oxu_C(0.0503);3g6j_B(0.0433);3oxu_B(0.0486);2noj_E(0.0388);2noj_G(0.0422);2xqw_A(0.0563);1c3d_A(0.0513);2a73_B(0.047);2noj_A(0.0471);2noj_C(0.046);4m76_A(0.0498);3d5r_A(0.0548);2gox_A(0.0568);3d5s_A(0.0483);3rj3_A(0.0518);2icf_B(0.0491);3rj3_B(0.0506);1ghq_A(0.0515);2win_F(0.0455);3l5n_B(0.0426);3oed_A(0.0504);2xwb_B(0.0472);2wy8_A(0.0546);2i07_B(0.052);2wy7_A(0.052);2hr0_B(0.0489);2wii_B(0.0489);2xwj_B(0.0513);2win_B(0.0442);2win_D(0.0428) Cluster-exclusive L:1 0.0388 1 1 acc:1 ENST00000408957 3 3d TIGD1 V61 61 412 3oxu_A(0.0534);3oxu_C(0.0503);3g6j_B(0.0433);3oxu_B(0.0486);2noj_E(0.0388);2noj_G(0.0422);2xqw_A(0.0563);1c3d_A(0.0513);2a73_B(0.047);2noj_A(0.0471);2noj_C(0.046);4m76_A(0.0498);3d5r_A(0.0548);2gox_A(0.0568);3d5s_A(0.0483);3rj3_A(0.0518);2icf_B(0.0491);3rj3_B(0.0506);1ghq_A(0.0515);2win_F(0.0455);3l5n_B(0.0426);3oed_A(0.0504);2xwb_B(0.0472);2wy8_A(0.0546);2i07_B(0.052);2wy7_A(0.052);2hr0_B(0.0489);2wii_B(0.0489);2xwj_B(0.0513);2win_B(0.0442);2win_D(0.0428) Cluster-exclusive I:1 0.0388 1 1 luad:1 ENST00000408957 3 3d TIGD1 M71 71 412 3oxu_A(0.0534);3oxu_C(0.0503);3g6j_B(0.0433);3oxu_B(0.0486);2noj_E(0.0388);2noj_G(0.0422);2xqw_A(0.0563);1c3d_A(0.0513);2a73_B(0.047);2noj_A(0.0471);2noj_C(0.046);4m76_A(0.0498);3d5r_A(0.0548);2gox_A(0.0568);3d5s_A(0.0483);3rj3_A(0.0518);2icf_B(0.0491);3rj3_B(0.0506);1ghq_A(0.0515);2win_F(0.0455);3l5n_B(0.0426);3oed_A(0.0504);2xwb_B(0.0472);2wy8_A(0.0546);2i07_B(0.052);2wy7_A(0.052);2hr0_B(0.0489);2wii_B(0.0489);2xwj_B(0.0513);2win_B(0.0442);2win_D(0.0428) Cluster-exclusive I:1 0.0388 1 1 ucec:1 ENST00000408957 3 3d ZNF443 P59 59 413 2fdb_M(0.0428);2fdb_N(0.0392) Cluster-exclusive S:2 0.0392 2 1 skcm:2 ENST00000301547 5 3d ZNF443 I91 91 413 2fdb_M(0.0428);2fdb_N(0.0392) Cluster-exclusive S:1 0.0392 1 1 gbm:1 ENST00000301547 5 3d ZNF443 G99 99 413 2fdb_M(0.0428);2fdb_N(0.0392) Cluster-exclusive V:1 0.0392 1 1 hnsc:1 ENST00000301547 5 3d ZNF443 G114 114 413 2fdb_M(0.0428);2fdb_N(0.0392) Cluster-exclusive R:1 0.0392 1 1 coadread:1 ENST00000301547 5 3d ZNF443 S116 116 413 2fdb_M(0.0428);2fdb_N(0.0392) Cluster-exclusive L:1 0.0392 1 1 luad:1 ENST00000301547 5 3d KEAP1 N485 485 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive S:1 0.0393 1 1 esca:1 ENST00000171111 5 3d KEAP1 E488 488 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive D:1 0.0393 1 1 ucec:1 ENST00000171111 5 3d KEAP1 G523 523 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive E:1 0.0393 1 1 luad:1 ENST00000171111 5 3d KEAP1 Y525 525 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive C:2 0.0393 2 2 hnsc:1|lihc:1 ENST00000171111 5 3d KEAP1 G527 527 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive C:1|V:1 0.0393 2 1 luad:2 ENST00000171111 5 3d KEAP1 M550 550 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive I:1 0.0393 1 1 paad:1 ENST00000171111 5 3d AHSA1 E311 311 416 1x53_A(0.0395) Cluster-exclusive Q:1 0.0395 1 1 luad:1 ENST00000216479 3 3d AHSA1 R314 314 416 1x53_A(0.0395) Cluster-exclusive Q:1|W:1 0.0395 2 2 esca:1|ucec:1 ENST00000216479 3 3d AHSA1 T315 315 416 1x53_A(0.0395) Cluster-exclusive M:1 0.0395 1 1 stad:1 ENST00000216479 3 3d AHSA1 R316 316 416 1x53_A(0.0395) Cluster-exclusive Q:2 0.0395 2 2 gbm:1|ucs:1 ENST00000216479 3 3d AHSA1 Q317 317 416 1x53_A(0.0395) Cluster-exclusive L:1 0.0395 1 1 lihc:1 ENST00000216479 3 3d ZEB2 L675 675 417 2da7_A(0.0395) Cluster-exclusive Q:1 0.0395 1 1 luad:1 ENST00000409487 3 3d ZEB2 S678 678 417 2da7_A(0.0395) Cluster-exclusive F:1 0.0395 1 1 stad:1 ENST00000409487 3 3d ZEB2 Q685 685 417 2da7_A(0.0395) Cluster-exclusive R:1 0.0395 1 1 lihc:1 ENST00000409487 3 3d ZEB2 E690 690 417 2da7_A(0.0395) Cluster-exclusive G:1 0.0395 1 1 stad:1 ENST00000409487 3 3d TSG101 Y32 32 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive N:1 0.0397 1 1 skcm:1 ENST00000251968 3 3d TSG101 L35 35 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive V:1 0.0397 1 1 luad:1 ENST00000251968 3 3d TSG101 I59 59 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive 0.0397 1 ENST00000251968 3 3d TSG101 P60 60 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive S:1 0.0397 1 1 skcm:1 ENST00000251968 3 3d TSG101 P71 71 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive S:1 0.0397 1 1 stad:1 ENST00000251968 3 3d TSG101 M131 131 418 1kpp_A(0.0397);1m4q_A(0.0659) Cluster-exclusive V:1 0.0397 1 1 brca:1 ENST00000251968 3 3d ITGA1 M276 276 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive I:1 0.0399 1 1 skcm:1 ENST00000282588 6 3d DDX39B N288 288 420 1xtk_A(0.0399) Cluster-exclusive I:1 0.0399 1 1 luad:1 ENST00000383508 2 3d DDX39B A314 314 420 1xtk_A(0.0399) Cluster-exclusive V:1 0.0399 1 1 paad:1 ENST00000383508 2 3d DDX39B R338 338 420 1xtk_A(0.0399) Cluster-exclusive Q:1 0.0399 1 1 coadread:1 ENST00000383508 2 3d DDX39B R339 339 420 1xtk_A(0.0399) Cluster-exclusive Q:1 0.0399 1 1 gbm:1 ENST00000383508 2 3d DDX39B L341 341 420 1xtk_A(0.0399) Cluster-exclusive I:2 0.0399 2 2 ucec:1|lusc:1 ENST00000383508 2 3d DDX39B R355 355 420 1xtk_A(0.0399) Cluster-exclusive L:1 0.0399 1 1 kirp:1 ENST00000383508 2 3d BMAL1 R83 83 421 4h10_A(0.0399) Cluster-exclusive Q:1 0.0399 1 1 paad:1 ENST00000403290 1 3d BMAL1 R84 84 421 4h10_A(0.0399) Cluster-exclusive C:1|H:3 0.0399 4 3 coadread:1|stad:2|luad:1 ENST00000403290 1 3d BMAL1 R85 85 421 4h10_A(0.0399) Cluster-exclusive W:1 0.0399 1 1 luad:1 ENST00000403290 1 3d BMAL1 M88 88 421 4h10_A(0.0399) Cluster-exclusive I:1 0.0399 1 1 coadread:1 ENST00000403290 1 3d ELOB R68 68 422 2ma9_B(0.0399) Cluster-exclusive W:1 0.0399 1 1 gbm:1 ENST00000409906 4 3d ELOB S110 110 422 2ma9_B(0.0399) Cluster-exclusive I:1 0.0399 1 1 ucec:1 ENST00000409906 4 3d ELOB A112 112 422 2ma9_B(0.0399) Cluster-exclusive V:1 0.0399 1 1 ucec:1 ENST00000409906 4 3d NONO Q72 72 423 3sde_B(0.0401) Cluster-exclusive K:1 0.0401 1 1 kirp:1 ENST00000276079 8 3d NONO R73 73 423 3sde_B(0.0401) Cluster-exclusive Q:1 0.0401 1 1 ucec:1 ENST00000276079 8 3d NONO R75 75 423 3sde_B(0.0401) Cluster-exclusive S:1|C:1 0.0401 2 2 laml:1|skcm:1 ENST00000276079 8 3d NONO E102 102 423 3sde_B(0.0401) Cluster-exclusive K:2 0.0401 2 1 ucec:2 ENST00000276079 8 3d NONO I114 114 423 3sde_B(0.0401) Cluster-exclusive L:1 0.0401 1 1 lusc:1 ENST00000276079 8 3d NONO R115 115 423 3sde_B(0.0401) Cluster-exclusive H:1 0.0401 1 1 ucec:1 ENST00000276079 8 3d NONO A122 122 423 3sde_B(0.0401) Cluster-exclusive V:1 0.0401 1 1 coadread:1 ENST00000276079 8 3d NONO A144 144 423 3sde_B(0.0401) Cluster-exclusive V:1 0.0401 1 1 skcm:1 ENST00000276079 8 3d ADSS1 L180 180 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive P:1 0.0402 1 1 cscc:1 ENST00000330877 2 3d ADSS1 R181 181 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive H:2 0.0402 2 2 coadread:1|stad:1 ENST00000330877 2 3d ADSS1 E191 191 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive K:1 0.0402 1 1 blca:1 ENST00000330877 2 3d ADSS1 F192 192 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive L:1 0.0402 1 1 stad:1 ENST00000330877 2 3d ADSS1 S193 193 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive F:3 0.0402 3 2 skcm:2|cscc:1 ENST00000330877 2 3d ADSS1 F196 196 424 1mf0_A(0.0498);1iwe_A(0.046);2dgn_A(0.0437);1lny_B(0.0456);1lny_A(0.0484);1mez_A(0.048);1loo_A(0.0402);1lon_A(0.0473) Cluster-exclusive L:1 0.0402 1 1 ucec:1 ENST00000330877 2 3d SLIT2 R493 493 425 2zmv_A(0.0404) Cluster-exclusive Q:3 0.0404 3 3 skcm:1|ucec:1|cscc:1 ENST00000504154 1 3d SLIT2 K495 495 425 2zmv_A(0.0404) Cluster-exclusive N:1 0.0404 1 1 paad:1 ENST00000504154 1 3d SLIT2 L496 496 425 2zmv_A(0.0404) Cluster-exclusive F:1 0.0404 1 1 cll:1 ENST00000504154 1 3d SLIT2 S497 497 425 2zmv_A(0.0404) Cluster-exclusive I:1 0.0404 1 1 acc:1 ENST00000504154 1 3d SLIT2 C500 500 425 2zmv_A(0.0404) Cluster-exclusive S:1 0.0404 1 1 luad:1 ENST00000504154 1 3d SLIT2 A502 502 425 2zmv_A(0.0404) Cluster-exclusive V:1 0.0404 1 1 luad:1 ENST00000504154 1 3d SLIT2 E529 529 425 2zmv_A(0.0404) Cluster-exclusive Q:1 0.0404 1 1 luad:1 ENST00000504154 1 3d SLIT2 H530 530 425 2zmv_A(0.0404) Cluster-exclusive L:1 0.0404 1 1 luad:1 ENST00000504154 1 3d EIF2AK2 S530 530 426 3uiu_A(0.0673);2a19_C(0.0407) Cluster-exclusive Y:1 0.0407 1 1 luad:1 ENST00000233057 4 3d EIF2AK2 E531 531 426 3uiu_A(0.0673);2a19_C(0.0407) Cluster-exclusive K:1 0.0407 1 1 thca:1 ENST00000233057 4 3d EIF2AK2 R534 534 426 3uiu_A(0.0673);2a19_C(0.0407) Cluster-exclusive M:1 0.0407 1 1 lihc:1 ENST00000233057 4 3d EIF2AK2 L536 536 426 3uiu_A(0.0673);2a19_C(0.0407) Cluster-exclusive F:1 0.0407 1 1 brca:1 ENST00000233057 4 3d POLI R372 372 428 3q8q_B(0.0536);3osn_A(0.0545);4eyh_B(0.0527);3q8r_B(0.0515);3q8p_B(0.0548);3q8s_B(0.0475);4ebd_A(0.048);4ebc_A(0.0409);4ebe_A(0.0522);3gv8_B(0.0524);3gv5_D(0.0526);3gv7_B(0.056);4fs1_A(0.0496);4fs2_A(0.0515);3gv5_B(0.0548) Cluster-exclusive H:1 0.0409 1 1 ucec:1 ENST00000579534 1 3d POLI R373 373 428 3q8q_B(0.0536);3osn_A(0.0545);4eyh_B(0.0527);3q8r_B(0.0515);3q8p_B(0.0548);3q8s_B(0.0475);4ebd_A(0.048);4ebc_A(0.0409);4ebe_A(0.0522);3gv8_B(0.0524);3gv5_D(0.0526);3gv7_B(0.056);4fs1_A(0.0496);4fs2_A(0.0515);3gv5_B(0.0548) Cluster-exclusive Q:1|L:1 0.0409 2 2 coadread:1|luad:1 ENST00000579534 1 3d POLI R382 382 428 3q8q_B(0.0536);3osn_A(0.0545);4eyh_B(0.0527);3q8r_B(0.0515);3q8p_B(0.0548);3q8s_B(0.0475);4ebd_A(0.048);4ebc_A(0.0409);4ebe_A(0.0522);3gv8_B(0.0524);3gv5_D(0.0526);3gv7_B(0.056);4fs1_A(0.0496);4fs2_A(0.0515);3gv5_B(0.0548) Cluster-exclusive C:1|L:1 0.0409 2 2 skcm:1|lusc:1 ENST00000579534 1 3d POLI H427 427 428 3q8q_B(0.0536);3osn_A(0.0545);4eyh_B(0.0527);3q8r_B(0.0515);3q8p_B(0.0548);3q8s_B(0.0475);4ebd_A(0.048);4ebc_A(0.0409);4ebe_A(0.0522);3gv8_B(0.0524);3gv5_D(0.0526);3gv7_B(0.056);4fs1_A(0.0496);4fs2_A(0.0515);3gv5_B(0.0548) Cluster-exclusive Y:2 0.0409 2 2 skcm:1|cscc:1 ENST00000579534 1 3d POLI T429 429 428 3q8q_B(0.0536);3osn_A(0.0545);4eyh_B(0.0527);3q8r_B(0.0515);3q8p_B(0.0548);3q8s_B(0.0475);4ebd_A(0.048);4ebc_A(0.0409);4ebe_A(0.0522);3gv8_B(0.0524);3gv5_D(0.0526);3gv7_B(0.056);4fs1_A(0.0496);4fs2_A(0.0515);3gv5_B(0.0548) Cluster-exclusive A:1 0.0409 1 1 brca:1 ENST00000579534 1 3d SMAD4 D355 355 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked V:2|G:2 0.0411 4 3 paad:1|coadread:2|prad:1 ENST00000342988 3 3d SMAD4 Q366 366 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked K:1 0.0411 1 1 hnsc:1 ENST00000342988 3 3d SNRPN C43 43 431 3pgw_B(0.0413) Cluster-exclusive R:1 0.0413 1 1 stad:1 ENST00000346403 6 3d SNRPN D44 44 431 3pgw_B(0.0413) Cluster-exclusive V:1 0.0413 1 1 skcm:1 ENST00000346403 6 3d SNRPN C45 45 431 3pgw_B(0.0413) Cluster-exclusive F:1 0.0413 1 1 luad:1 ENST00000346403 6 3d SNRPN G68 68 431 3pgw_B(0.0413) Cluster-exclusive C:1 0.0413 1 1 luad:1 ENST00000346403 6 3d SNRPN L42 42 432 3pgw_B(0.0413) Cluster-exclusive V:1 0.0413 1 1 stad:1 ENST00000346403 6 3d RBP4 T41 41 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive I:1 0.0414 1 1 lihc:1 ENST00000371464 3 3d RBP4 A44 44 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive D:1 0.0414 1 1 lusm:1 ENST00000371464 3 3d RBP4 T131 131 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive M:2 0.0414 2 2 paad:1|luad:1 ENST00000371464 3 3d RBP4 A133 133 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive V:1 0.0414 1 1 cscc:1 ENST00000371464 3 3d RBP4 S156 156 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive F:2 0.0414 2 2 brca:1|skcm:1 ENST00000371464 3 3d RBP4 L162 162 433 4psq_A(0.0434);4psq_B(0.0433);1rbp_A(0.0428);4o9s_A(0.0471);3fmz_B(0.0469);3fmz_A(0.0476);4o9s_B(0.0414);2wq9_A(0.0479) Cluster-exclusive V:1 0.0414 1 1 luad:1 ENST00000371464 3 3d MRPL3 K131 131 434 3j7y_E(0.0415) Cluster-exclusive T:1|I:1 0.0415 2 1 coadread:2 ENST00000264995 3 3d MRPL3 I161 161 434 3j7y_E(0.0415) Cluster-exclusive M:1 0.0415 1 1 lusm:1 ENST00000264995 3 3d MRPL3 F164 164 434 3j7y_E(0.0415) Cluster-exclusive L:1 0.0415 1 1 ucec:1 ENST00000264995 3 3d MRPL3 R166 166 434 3j7y_E(0.0415) Cluster-exclusive Q:2|L:1 0.0415 3 3 prad:1|lihc:1|luad:1 ENST00000264995 3 3d MRPL3 I187 187 434 3j7y_E(0.0415) Cluster-exclusive N:1 0.0415 1 1 stad:1 ENST00000264995 3 3d MRPL3 P189 189 434 3j7y_E(0.0415) Cluster-exclusive Q:1 0.0415 1 1 blca:1 ENST00000264995 3 3d DLC1 A350 350 436 2wl1_A(0.0418) Cluster-exclusive V:4 0.0418 4 3 coadread:2|stad:1|lihc:1 ENST00000276297 4 3d DLC1 R351 351 436 2wl1_A(0.0418) Cluster-exclusive W:3 0.0418 3 3 prad:1|hnsc:1|lihc:1 ENST00000276297 4 3d DLC1 D353 353 436 2wl1_A(0.0418) Cluster-exclusive N:1 0.0418 1 1 cscc:1 ENST00000276297 4 3d DLC1 M355 355 436 2wl1_A(0.0418) Cluster-exclusive I:2 0.0418 2 2 coadread:1|skcm:1 ENST00000276297 4 3d DLC1 S414 414 436 2wl1_A(0.0418) Cluster-exclusive Y:1 0.0418 1 1 ucec:1 ENST00000276297 4 3d GRB2 E130 130 437 1qg1_E(0.0419) Cluster-exclusive D:1 0.0419 1 1 ov:1 ENST00000316804 5 3d MAP2K1 A132 132 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot-linked V:1 0.0422 1 1 coadread:1 ENST00000307102 5 3d ITGB2 K174 174 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive N:1 0.0422 1 1 ucec:1 ENST00000302347 5 3d ITGB2 A270 270 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive T:1 0.0422 1 1 stad:1 ENST00000302347 5 3d ITGB2 G271 271 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive S:1|C:1 0.0422 2 2 prad:1|cscc:1 ENST00000302347 5 3d ITGB2 G273 273 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive R:1|E:1 0.0422 2 2 skcm:1|cscc:1 ENST00000302347 5 3d ITGB2 A277 277 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive S:1|T:1 0.0422 2 2 stad:1|lusc:1 ENST00000302347 5 3d ITGB2 D300 300 439 3k71_B(0.0482);3k72_B(0.043);3k71_D(0.0445);3k6s_F(0.0454);3k6s_H(0.0443);3k72_D(0.0441);3k71_F(0.0424);3k6s_B(0.0487);3k6s_D(0.0449);3k71_H(0.0422) Cluster-exclusive H:1 0.0422 1 1 ov:1 ENST00000302347 5 3d MAGIX R143 143 440 2djt_A(0.0422) Cluster-exclusive W:1 0.0422 1 1 cll:1 ENST00000595224 1 3d MAGIX T149 149 440 2djt_A(0.0422) Cluster-exclusive S:1 0.0422 1 1 luad:1 ENST00000595224 1 3d MAGIX P150 150 440 2djt_A(0.0422) Cluster-exclusive S:1 0.0422 1 1 skcm:1 ENST00000595224 1 3d MAGIX L151 151 440 2djt_A(0.0422) Cluster-exclusive V:1 0.0422 1 1 coadread:1 ENST00000595224 1 3d MAGIX V153 153 440 2djt_A(0.0422) Cluster-exclusive L:1 0.0422 1 1 hnsc:1 ENST00000595224 1 3d MAGIX H187 187 440 2djt_A(0.0422) Cluster-exclusive Y:1 0.0422 1 1 lihc:1 ENST00000595224 1 3d DNAJC6 P242 242 441 3n0a_A(0.0428) Cluster-exclusive S:1 0.0428 1 1 cscc:1 ENST00000395325 3 3d DNAJC6 F243 243 441 3n0a_A(0.0428) Cluster-exclusive L:1 0.0428 1 1 hnsc:1 ENST00000395325 3 3d DNAJC6 G250 250 441 3n0a_A(0.0428) Cluster-exclusive E:1 0.0428 1 1 ucec:1 ENST00000395325 3 3d DNAJC6 C251 251 441 3n0a_A(0.0428) Cluster-exclusive F:1 0.0428 1 1 luad:1 ENST00000395325 3 3d DNAJC6 R252 252 441 3n0a_A(0.0428) Cluster-exclusive C:2|S:1|H:2 0.0428 5 4 coadread:1|stad:2|lusc:1|cscc:1 ENST00000395325 3 3d DNAJC6 R278 278 441 3n0a_A(0.0428) Cluster-exclusive H:1 0.0428 1 1 gbm:1 ENST00000395325 3 3d DNAJC6 H302 302 441 3n0a_A(0.0428) Cluster-exclusive Y:1 0.0428 1 1 skcm:1 ENST00000395325 3 3d DNAJC6 I284 284 442 3n0a_A(0.0428) Cluster-exclusive M:1 0.0428 1 1 lusc:1 ENST00000395325 3 3d ZNF548 A238 238 443 2jm6_B(0.0431) Cluster-exclusive T:1|V:1 0.0431 2 2 paad:1|coadread:1 ENST00000366197 5 3d ZNF548 N239 239 443 2jm6_B(0.0431) Cluster-exclusive K:1 0.0431 1 1 coadread:1 ENST00000366197 5 3d ZNF548 C286 286 443 2jm6_B(0.0431) Cluster-exclusive R:1 0.0431 1 1 blca:1 ENST00000366197 5 3d ZNF548 K288 288 443 2jm6_B(0.0431) Cluster-exclusive E:1 0.0431 1 1 luad:1 ENST00000366197 5 3d ZNF548 F289 289 443 2jm6_B(0.0431) Cluster-exclusive L:1 0.0431 1 1 coadread:1 ENST00000366197 5 3d ZNF548 R291 291 443 2jm6_B(0.0431) Cluster-exclusive W:1|L:1 0.0431 2 2 lihc:1|cscc:1 ENST00000366197 5 3d JPH2 D274 274 445 2dmb_A(0.0432) Cluster-exclusive A:1 0.0432 1 1 coadread:1 ENST00000372980 3 3d JPH2 A277 277 445 2dmb_A(0.0432) Cluster-exclusive T:2 0.0432 2 2 coadread:1|stad:1 ENST00000372980 3 3d JPH2 D298 298 445 2dmb_A(0.0432) Cluster-exclusive N:1 0.0432 1 1 skcm:1 ENST00000372980 3 3d JPH2 E307 307 445 2dmb_A(0.0432) Cluster-exclusive K:3 0.0432 3 3 brca:1|skcm:1|cscc:1 ENST00000372980 3 3d JPH2 R308 308 445 2dmb_A(0.0432) Cluster-exclusive C:1|H:3 0.0432 4 3 mmyl:1|stad:2|gbm:1 ENST00000372980 3 3d JPH2 K348 348 445 2dmb_A(0.0432) Cluster-exclusive T:1 0.0432 1 1 skcm:1 ENST00000372980 3 3d JPH2 T350 350 445 2dmb_A(0.0432) Cluster-exclusive N:1 0.0432 1 1 lusc:1 ENST00000372980 3 3d JPH2 R352 352 445 2dmb_A(0.0432) Cluster-exclusive L:1 0.0432 1 1 luad:1 ENST00000372980 3 3d JPH2 R353 353 445 2dmb_A(0.0432) Cluster-exclusive H:1 0.0432 1 1 prad:1 ENST00000372980 3 3d ZNF548 F233 233 446 2roc_A(0.0432) Cluster-exclusive L:1 0.0432 1 1 coadread:1 ENST00000366197 5 3d AMY2A P59 59 447 3bai_A(0.0479);1u33_A(0.0482);3ole_A(0.0517);2qmk_A(0.0539);1kb3_A(0.0458);3baj_A(0.0477);1u30_A(0.0459);1jxj_A(0.0439);3olg_A(0.0477);4x9y_A(0.0846);3ij9_A(0.0466);1q4n_X(0.046);1smd_A(0.0432) Cluster-exclusive Q:1|S:1 0.0432 2 2 blca:1|luad:1 ENST00000414303 2 3d AMY2A P72 72 447 3bai_A(0.0479);1u33_A(0.0482);3ole_A(0.0517);2qmk_A(0.0539);1kb3_A(0.0458);3baj_A(0.0477);1u30_A(0.0459);1jxj_A(0.0439);3olg_A(0.0477);4x9y_A(0.0846);3ij9_A(0.0466);1q4n_X(0.046);1smd_A(0.0432) Cluster-exclusive H:1 0.0432 1 1 luad:1 ENST00000414303 2 3d AMY2A R76 76 447 3bai_A(0.0479);1u33_A(0.0482);3ole_A(0.0517);2qmk_A(0.0539);1kb3_A(0.0458);3baj_A(0.0477);1u30_A(0.0459);1jxj_A(0.0439);3olg_A(0.0477);4x9y_A(0.0846);3ij9_A(0.0466);1q4n_X(0.046);1smd_A(0.0432) Cluster-exclusive I:2 0.0432 2 2 lihc:1|cesc:1 ENST00000414303 2 3d AMY2A P79 79 447 3bai_A(0.0479);1u33_A(0.0482);3ole_A(0.0517);2qmk_A(0.0539);1kb3_A(0.0458);3baj_A(0.0477);1u30_A(0.0459);1jxj_A(0.0439);3olg_A(0.0477);4x9y_A(0.0846);3ij9_A(0.0466);1q4n_X(0.046);1smd_A(0.0432) Cluster-exclusive A:1|Q:1 0.0432 2 2 ucs:1|luad:1 ENST00000414303 2 3d AMY1A A322 322 448 1b2y_A(0.0528);3ole_A(0.0517);2cpu_A(0.0529);3old_A(0.0529);1kb3_A(0.0526);4gqr_A(0.0596);1kbk_A(0.0546);1u2y_A(0.0537);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);3bay_A(0.0507);1xd0_A(0.0557);3ij9_A(0.0561);3ij8_A(0.0606);1xh0_A(0.0538);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);3bai_A(0.0567);1u33_A(0.0566);2qmk_A(0.0538);3bak_A(0.0537);3baj_A(0.0537);1u30_A(0.0553);1hny_A(0.0568);1kbb_A(0.0505);1xgz_A(0.0535);1xcx_A(0.0541);3cpu_A(0.0545);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive T:1 0.0432 1 1 stad:1 ENST00000330330 5 3d AMY1A I327 327 448 1b2y_A(0.0528);3ole_A(0.0517);2cpu_A(0.0529);3old_A(0.0529);1kb3_A(0.0526);4gqr_A(0.0596);1kbk_A(0.0546);1u2y_A(0.0537);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);3bay_A(0.0507);1xd0_A(0.0557);3ij9_A(0.0561);3ij8_A(0.0606);1xh0_A(0.0538);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);3bai_A(0.0567);1u33_A(0.0566);2qmk_A(0.0538);3bak_A(0.0537);3baj_A(0.0537);1u30_A(0.0553);1hny_A(0.0568);1kbb_A(0.0505);1xgz_A(0.0535);1xcx_A(0.0541);3cpu_A(0.0545);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive V:1 0.0432 1 1 luad:1 ENST00000330330 5 3d AMY1A D332 332 448 1b2y_A(0.0528);3ole_A(0.0517);2cpu_A(0.0529);3old_A(0.0529);1kb3_A(0.0526);4gqr_A(0.0596);1kbk_A(0.0546);1u2y_A(0.0537);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);3bay_A(0.0507);1xd0_A(0.0557);3ij9_A(0.0561);3ij8_A(0.0606);1xh0_A(0.0538);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);3bai_A(0.0567);1u33_A(0.0566);2qmk_A(0.0538);3bak_A(0.0537);3baj_A(0.0537);1u30_A(0.0553);1hny_A(0.0568);1kbb_A(0.0505);1xgz_A(0.0535);1xcx_A(0.0541);3cpu_A(0.0545);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive E:1 0.0432 1 1 luad:1 ENST00000330330 5 3d AMY1A W331 331 449 1b2y_A(0.0528);2cpu_A(0.0529);3ole_A(0.0517);1kb3_A(0.0526);3old_A(0.0529);1xv8_A(0.0593);4gqq_A(0.0549);1kbk_A(0.0546);4gqr_A(0.0596);1u2y_A(0.0537);3olg_A(0.0573);3oli_A(0.0574);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);1xd0_A(0.0557);3bay_A(0.0507);3ij9_A(0.0561);1xh0_A(0.0538);3ij8_A(0.0606);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);1u33_A(0.0566);1mfu_A(0.061);3bai_A(0.0567);3bak_A(0.0537);2qmk_A(0.0538);3baj_A(0.0537);1u30_A(0.0553);1jxk_A(0.0584);1c8q_A(0.0576);1jxj_A(0.0606);1hny_A(0.0568);3blp_X(0.0596);1kbb_A(0.0505);1xgz_A(0.0535);3cpu_A(0.0545);1xcx_A(0.0541);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive C:1 0.0432 1 1 luad:1 ENST00000330330 5 3d TCF21 E141 141 451 3pq1_B(0.0433) Cluster-exclusive K:1 0.0433 1 1 luad:1 ENST00000237316 3 3d TCF21 G143 143 451 3pq1_B(0.0433) Cluster-exclusive R:1|W:1 0.0433 2 2 coadread:1|luad:1 ENST00000237316 3 3d TCF21 Y144 144 451 3pq1_B(0.0433) Cluster-exclusive H:1 0.0433 1 1 stad:1 ENST00000237316 3 3d TCF21 P147 147 451 3pq1_B(0.0433) Cluster-exclusive A:1 0.0433 1 1 hnsc:1 ENST00000237316 3 3d TCF21 E161 161 451 3pq1_B(0.0433) Cluster-exclusive K:1 0.0433 1 1 hnsc:1 ENST00000237316 3 3d ATP4A R330 330 452 3ixz_A(0.0436) Cluster-exclusive Q:2|W:2 0.0436 4 4 paad:1|stad:1|blca:1|ucec:1 ENST00000262623 3 3d ATP4A A331 331 452 3ixz_A(0.0436) Cluster-exclusive D:1 0.0436 1 1 paad:1 ENST00000262623 3 3d ATP4A M332 332 452 3ixz_A(0.0436) Cluster-exclusive I:1 0.0436 1 1 skcm:1 ENST00000262623 3 3d NONO E162 162 453 3rbs_A(0.0439) Cluster-exclusive K:1 0.0439 1 1 coadread:1 ENST00000276079 8 3d NONO I180 180 453 3rbs_A(0.0439) Cluster-exclusive T:1 0.0439 1 1 lihc:1 ENST00000276079 8 3d NONO R184 184 453 3rbs_A(0.0439) Cluster-exclusive L:1 0.0439 1 1 skcm:1 ENST00000276079 8 3d NONO C208 208 453 3rbs_A(0.0439) Cluster-exclusive Y:1 0.0439 1 1 hnsc:1 ENST00000276079 8 3d NONO S212 212 453 3rbs_A(0.0439) Cluster-exclusive F:1 0.0439 1 1 hnsc:1 ENST00000276079 8 3d NONO F213 213 453 3rbs_A(0.0439) Cluster-exclusive L:1 0.0439 1 1 ov:1 ENST00000276079 8 3d NONO P226 226 453 3rbs_A(0.0439) Cluster-exclusive L:1 0.0439 1 1 skcm:1 ENST00000276079 8 3d NONO Q229 229 453 3rbs_A(0.0439) Cluster-exclusive K:1 0.0439 1 1 gbm:1 ENST00000276079 8 3d CRY1 K329 329 454 4k0r_A(0.044) Cluster-exclusive N:1 0.044 1 1 lihc:1 ENST00000008527 5 3d CRY1 A331 331 454 4k0r_A(0.044) Cluster-exclusive V:1 0.044 1 1 esca:1 ENST00000008527 5 3d CRY1 E332 332 454 4k0r_A(0.044) Cluster-exclusive Q:1 0.044 1 1 luad:1 ENST00000008527 5 3d CRY1 G333 333 454 4k0r_A(0.044) Cluster-exclusive D:1 0.044 1 1 hnsc:1 ENST00000008527 5 3d CRY1 R334 334 454 4k0r_A(0.044) Cluster-exclusive L:1 0.044 1 1 lusc:1 ENST00000008527 5 3d CRY1 D341 341 454 4k0r_A(0.044) Cluster-exclusive H:1 0.044 1 1 hnsc:1 ENST00000008527 5 3d CRY1 M470 470 454 4k0r_A(0.044) Cluster-exclusive L:1 0.044 1 1 skcm:1 ENST00000008527 5 3d RPS6KB1 L94 94 455 4l45_A(0.048);4l43_A(0.044) Cluster-exclusive R:1 0.044 1 1 ucec:1 ENST00000225577 4 3d RPS6KB1 R95 95 455 4l45_A(0.048);4l43_A(0.044) Cluster-exclusive W:2 0.044 2 2 brca:1|coadread:1 ENST00000225577 4 3d RPS6KB1 V105 105 455 4l45_A(0.048);4l43_A(0.044) Cluster-exclusive A:1 0.044 1 1 lihc:1 ENST00000225577 4 3d RPS6KB1 Q107 107 455 4l45_A(0.048);4l43_A(0.044) Cluster-exclusive E:1 0.044 1 1 luad:1 ENST00000225577 4 3d RPS6KB1 Q389 389 455 4l45_A(0.048);4l43_A(0.044) Cluster-exclusive E:1 0.044 1 1 luad:1 ENST00000225577 4 3d CASP1 A329 329 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive T:1 0.0442 1 1 ov:1 ENST00000436863 3 3d CASP1 C331 331 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive W:1 0.0442 1 1 prad:1 ENST00000436863 3 3d CASP1 S332 332 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive Y:1 0.0442 1 1 lihc:1 ENST00000436863 3 3d CASP1 P335 335 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive L:1 0.0442 1 1 luad:1 ENST00000436863 3 3d CASP1 M386 386 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive I:1 0.0442 1 1 coadread:1 ENST00000436863 3 3d CASP1 T388 388 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive N:1 0.0442 1 1 luad:1 ENST00000436863 3 3d CASP1 E390 390 456 1rwn_B(0.0507);1rwm_B(0.0453);1rwk_B(0.049);3d6h_B(0.0526);1rwp_B(0.0493);1rwo_B(0.0507);3ns7_B(0.0569);1sc3_B(0.0511);1ice_B(0.0511);1ibc_B(0.0586);2hbq_B(0.0543);2hbr_B(0.0494);1rwv_B(0.06);2h48_B(0.0554);1rwx_B(0.0555);1rww_B(0.0442) Cluster-exclusive K:1 0.0442 1 1 luad:1 ENST00000436863 3 3d ZNF320 R237 237 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive S:1 0.0447 1 1 hnsc:1 ENST00000391781 2 3d ZNF320 S238 238 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive I:1 0.0447 1 1 lihc:1 ENST00000391781 2 3d ZNF320 G241 241 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive E:1 0.0447 1 1 coadread:1 ENST00000391781 2 3d ZNF320 E242 242 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive D:1|K:1 0.0447 2 2 coadread:1|cscc:1 ENST00000391781 2 3d ZNF320 H295 295 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive Y:1 0.0447 1 1 skcm:1 ENST00000391781 2 3d ZNF320 T296 296 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive I:1 0.0447 1 1 ucec:1 ENST00000391781 2 3d ZNF320 K299 299 457 2jll_A(0.0447);2xy1_A(0.0454);2xyc_A(0.0474) Cluster-exclusive I:1 0.0447 1 1 stad:1 ENST00000391781 2 3d HDAC3 Q52 52 458 4a69_A(0.0448);4a69_B(0.0476) Cluster-exclusive R:1 0.0448 1 1 ucec:1 ENST00000305264 3 3d HDAC3 F101 101 458 4a69_A(0.0448);4a69_B(0.0476) Cluster-exclusive S:1 0.0448 1 1 skcm:1 ENST00000305264 3 3d HDAC3 S105 105 458 4a69_A(0.0448);4a69_B(0.0476) Cluster-exclusive P:1|L:1 0.0448 2 2 lusm:1|skcm:1 ENST00000305264 3 3d HDAC3 R106 106 458 4a69_A(0.0448);4a69_B(0.0476) Cluster-exclusive C:1|H:1 0.0448 2 2 coadread:1|stad:1 ENST00000305264 3 3d HDAC3 A110 110 458 4a69_A(0.0448);4a69_B(0.0476) Cluster-exclusive T:2 0.0448 2 1 ucec:2 ENST00000305264 3 3d TRIM24 E999 999 459 2yyn_C(0.0484);2yyn_D(0.0526);2yyn_A(0.0513);2yyn_B(0.0448) Cluster-exclusive K:1 0.0448 1 1 stad:1 ENST00000343526 4 3d TRIM24 L1001 1001 459 2yyn_C(0.0484);2yyn_D(0.0526);2yyn_A(0.0513);2yyn_B(0.0448) Cluster-exclusive V:1 0.0448 1 1 brca:1 ENST00000343526 4 3d TRIM24 K1002 1002 459 2yyn_C(0.0484);2yyn_D(0.0526);2yyn_A(0.0513);2yyn_B(0.0448) Cluster-exclusive N:1 0.0448 1 1 ov:1 ENST00000343526 4 3d TRIM24 F1010 1010 459 2yyn_C(0.0484);2yyn_D(0.0526);2yyn_A(0.0513);2yyn_B(0.0448) Cluster-exclusive C:1 0.0448 1 1 hnsc:1 ENST00000343526 4 3d PPP2R1A S256 256 460 2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);3dw8_D(0.055);4i5l_D(0.054);4i5n_A(0.0465);1b3u_B(0.045);4i5n_D(0.0483);1b3u_A(0.0496);2ie3_A(0.0524);4i5l_A(0.053);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive F:4|Y:2 0.045 6 2 ucs:2|ucec:4 ENST00000322088 6 3d PPP2R1A W257 257 460 2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);3dw8_D(0.055);4i5l_D(0.054);4i5n_A(0.0465);1b3u_B(0.045);4i5n_D(0.0483);1b3u_A(0.0496);2ie3_A(0.0524);4i5l_A(0.053);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive C:1 0.045 1 1 ov:1 ENST00000322088 6 3d PPP2R1A R258 258 460 2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);3dw8_D(0.055);4i5l_D(0.054);4i5n_A(0.0465);1b3u_B(0.045);4i5n_D(0.0483);1b3u_A(0.0496);2ie3_A(0.0524);4i5l_A(0.053);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Hotspot-linked C:1|H:3 0.045 4 3 coadread:1|ucec:2|luad:1 ENST00000322088 6 3d PPP2R1A R260 260 460 2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);3dw8_D(0.055);4i5l_D(0.054);4i5n_A(0.0465);1b3u_B(0.045);4i5n_D(0.0483);1b3u_A(0.0496);2ie3_A(0.0524);4i5l_A(0.053);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive C:1|G:1 0.045 2 2 ov:1|lihc:1 ENST00000322088 6 3d PPP2R1A E297 297 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive D:1|K:1 0.045 2 2 prad:1|luad:1 ENST00000322088 6 3d PPP2R1A V298 298 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive L:1 0.045 1 1 ucec:1 ENST00000322088 6 3d PPFIA3 V858 858 462 3tad_B(0.0499);3tac_B(0.0477);3tad_A(0.045) Cluster-exclusive M:1 0.045 1 1 stad:1 ENST00000334186 4 3d PPFIA3 A860 860 462 3tad_B(0.0499);3tac_B(0.0477);3tad_A(0.045) Cluster-exclusive T:1 0.045 1 1 prad:1 ENST00000334186 4 3d PPFIA3 C861 861 462 3tad_B(0.0499);3tac_B(0.0477);3tad_A(0.045) Cluster-exclusive Y:1 0.045 1 1 hnsc:1 ENST00000334186 4 3d PPFIA3 R862 862 462 3tad_B(0.0499);3tac_B(0.0477);3tad_A(0.045) Cluster-exclusive W:1 0.045 1 1 stad:1 ENST00000334186 4 3d POTEE A930 930 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive V:1 0.0451 1 1 prad:1 ENST00000356920 5 3d POTEE S933 933 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive C:1|I:1 0.0451 2 2 skcm:1|luad:1 ENST00000356920 5 3d POTEE S935 935 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive F:1 0.0451 1 1 skcm:1 ENST00000356920 5 3d POTEE E937 937 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive K:2 0.0451 2 2 skcm:1|lusc:1 ENST00000356920 5 3d POTEE K938 938 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive R:1|M:1 0.0451 2 2 stad:1|skcm:1 ENST00000356920 5 3d POTEE S939 939 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive R:1|N:1 0.0451 2 2 stad:1|skcm:1 ENST00000356920 5 3d POTEE T949 949 463 1hlu_A(0.0451);3b63_L(0.0495) Cluster-exclusive I:1 0.0451 1 1 skcm:1 ENST00000356920 5 3d ITGAM L154 154 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive F:1 0.0453 1 1 luad:1 ENST00000287497 8 3d ITGAM D156 156 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive H:1 0.0453 1 1 luad:1 ENST00000287497 8 3d ITGAM S158 158 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive C:1|Y:1 0.0453 2 2 ucec:1|cesc:1 ENST00000287497 8 3d ITGAM F166 166 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive V:1|L:1 0.0453 2 2 esca:1|lihc:1 ENST00000287497 8 3d ITGAM R224 224 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive Q:2 0.0453 2 2 coadread:1|thca:1 ENST00000287497 8 3d ITGAM T225 225 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive A:1 0.0453 1 1 kich:1 ENST00000287497 8 3d ITGAM D258 258 464 1mf7_A(0.0514);1jlm_A(0.0453);1na5_A(0.0595) Cluster-exclusive N:1 0.0453 1 1 skcm:1 ENST00000287497 8 3d ANKLE2 E318 318 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive K:1 0.0453 1 1 skcm:1 ENST00000357997 5 3d ANKLE2 A612 612 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive D:1 0.0453 1 1 stad:1 ENST00000357997 5 3d ANKLE2 L550 550 466 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive F:1 0.0453 1 1 skcm:1 ENST00000357997 5 3d TTC14 A689 689 467 3ikm_A(0.0453) Cluster-exclusive T:1 0.0453 1 1 coadread:1 ENST00000296015 4 3d TTC14 H690 690 467 3ikm_A(0.0453) Cluster-exclusive Y:1 0.0453 1 1 paad:1 ENST00000296015 4 3d TTC14 S693 693 467 3ikm_A(0.0453) Cluster-exclusive L:1 0.0453 1 1 skcm:1 ENST00000296015 4 3d TTC14 R694 694 467 3ikm_A(0.0453) Cluster-exclusive H:1 0.0453 1 1 luad:1 ENST00000296015 4 3d TTC14 D695 695 467 3ikm_A(0.0453) Cluster-exclusive N:1 0.0453 1 1 paad:1 ENST00000296015 4 3d TTC14 F696 696 467 3ikm_A(0.0453) Cluster-exclusive L:1 0.0453 1 1 coadread:1 ENST00000296015 4 3d TTC14 P727 727 467 3ikm_A(0.0453) Cluster-exclusive S:1 0.0453 1 1 skcm:1 ENST00000296015 4 3d S100A14 E39 39 468 2m0r_A(0.0456);2m0r_B(0.0466) Cluster-exclusive K:1 0.0456 1 1 skcm:1 ENST00000344616 2 3d S100A14 K78 78 468 2m0r_A(0.0456);2m0r_B(0.0466) Cluster-exclusive N:1 0.0456 1 1 lihc:1 ENST00000344616 2 3d S100A14 E80 80 468 2m0r_A(0.0456);2m0r_B(0.0466) Cluster-exclusive D:1 0.0456 1 1 kirc:1 ENST00000344616 2 3d S100A14 R82 82 468 2m0r_A(0.0456);2m0r_B(0.0466) Cluster-exclusive M:1 0.0456 1 1 nbl:1 ENST00000344616 2 3d S100A14 S83 83 468 2m0r_A(0.0456);2m0r_B(0.0466) Cluster-exclusive T:1 0.0456 1 1 gbm:1 ENST00000344616 2 3d ADGRB2 P1425 1425 469 1yxm_A(0.0459) Cluster-exclusive L:2 0.0459 2 2 coadread:1|gbm:1 ENST00000373658 3 3d ADGRB2 P1427 1427 469 1yxm_A(0.0459) Cluster-exclusive L:1 0.0459 1 1 coadread:1 ENST00000373658 3 3d ADGRB2 P1428 1428 469 1yxm_A(0.0459) Cluster-exclusive L:1 0.0459 1 1 lihc:1 ENST00000373658 3 3d ADGRB2 A1432 1432 469 1yxm_A(0.0459) Cluster-exclusive S:1 0.0459 1 1 esca:1 ENST00000373658 3 3d ADGRB2 R1433 1433 469 1yxm_A(0.0459) Cluster-exclusive H:1 0.0459 1 1 stad:1 ENST00000373658 3 3d PTPRD A420 420 470 2dlh_A(0.046) Cluster-exclusive T:1 0.046 1 1 stad:1 ENST00000356435 5 3d PTPRD P421 421 470 2dlh_A(0.046) Cluster-exclusive Q:1|S:1|L:1 0.046 3 2 acc:1|skcm:2 ENST00000356435 5 3d PTPRD E440 440 470 2dlh_A(0.046) Cluster-exclusive D:1 0.046 1 1 stad:1 ENST00000356435 5 3d PTPRD P441 441 470 2dlh_A(0.046) Cluster-exclusive H:1 0.046 1 1 luad:1 ENST00000356435 5 3d PTPRD G450 450 470 2dlh_A(0.046) Cluster-exclusive A:1 0.046 1 1 luad:1 ENST00000356435 5 3d PTPRD R452 452 470 2dlh_A(0.046) Cluster-exclusive I:1 0.046 1 1 coadread:1 ENST00000356435 5 3d PTPRD A494 494 470 2dlh_A(0.046) Cluster-exclusive S:2 0.046 2 1 luad:2 ENST00000356435 5 3d PTPRD D500 500 470 2dlh_A(0.046) Cluster-exclusive Y:1|N:1 0.046 2 2 skcm:1|luad:1 ENST00000356435 5 3d PTPRD P502 502 470 2dlh_A(0.046) Cluster-exclusive L:1 0.046 1 1 skcm:1 ENST00000356435 5 3d PTPRD L503 503 470 2dlh_A(0.046) Cluster-exclusive I:1 0.046 1 1 hnsc:1 ENST00000356435 5 3d EP300 F1373 1373 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot-linked L:1 0.0464 1 1 brca:1 ENST00000263253 7 3d ITGB1 K163 163 475 4wk0_B(0.0955);3vi3_D(0.0502);3vi3_B(0.0464);4wk2_B(0.0897);4wjk_B(0.0993) Cluster-exclusive T:1 0.0464 1 1 coadread:1 ENST00000302278 3 3d ITGB1 V236 236 475 4wk0_B(0.0955);3vi3_D(0.0502);3vi3_B(0.0464);4wk2_B(0.0897);4wjk_B(0.0993) Cluster-exclusive A:1 0.0464 1 1 luad:1 ENST00000302278 3 3d COL3A1 P182 182 476 1jmo_A(0.0465) Cluster-exclusive L:2 0.0465 2 2 skcm:1|lusc:1 ENST00000304636 3 3d COL3A1 G183 183 476 1jmo_A(0.0465) Cluster-exclusive C:1 0.0465 1 1 stad:1 ENST00000304636 3 3d COL3A1 P184 184 476 1jmo_A(0.0465) Cluster-exclusive S:1 0.0465 1 1 skcm:1 ENST00000304636 3 3d COL3A1 P185 185 476 1jmo_A(0.0465) Cluster-exclusive T:1 0.0465 1 1 luad:1 ENST00000304636 3 3d COL3A1 G186 186 476 1jmo_A(0.0465) Cluster-exclusive D:1 0.0465 1 1 skcm:1 ENST00000304636 3 3d TP53 K132 132 477 4lof_A(0.0467) Hotspot Q:1|R:7|T:3|E:6|M:1|N:16 0.0467 34 16 acc:1|brca:6|mmyl:1|paad:3|coadread:2|esca:1|ucs:1|blca:4|hnsc:1|ov:6|lusc:1|lgg:1|stad:1|gbm:1|cesc:1|luad:3 ENST00000269305 4 3d TP53 M133 133 477 4lof_A(0.0467) Hotspot-linked R:1|K:2 0.0467 3 3 brca:1|paad:1|hnsc:1 ENST00000269305 4 3d TP53 F134 134 477 4lof_A(0.0467) Hotspot-linked S:1|C:1|V:2|L:2 0.0467 6 5 stad:1|esca:1|hnsc:1|ov:1|skcm:2 ENST00000269305 4 3d TP53 C135 135 477 4lof_A(0.0467) Hotspot R:3|S:2|F:9|W:2|G:1|Y:9 0.0467 26 12 acc:1|brca:5|paad:1|coadread:3|prad:2|stad:2|esca:5|blca:1|ov:2|lusc:1|lgg:1|luad:2 ENST00000269305 4 3d TP53 E271 271 477 4lof_A(0.0467) Hotspot-linked Q:1|V:1|K:14 0.0467 16 10 brca:1|stad:1|esca:1|gbm:1|blca:4|hnsc:3|lihc:1|lusc:2|cesc:1|luad:1 ENST00000269305 4 3d MTOR A1971 1971 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive S:1|T:2 0.0468 3 3 cll:1|gbm:1|lihc:1 ENST00000361445 4 3d MTOR I1973 1973 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive F:2 0.0468 2 2 brca:1|kirc:1 ENST00000361445 4 3d MTOR Y1974 1974 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive C:1 0.0468 1 1 ucec:1 ENST00000361445 4 3d MTOR T1977 1977 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive R:1|S:1|K:1 0.0468 3 3 prad:1|cll:1|kirc:1 ENST00000361445 4 3d MTOR M1998 1998 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive I:1 0.0468 1 1 kirc:1 ENST00000361445 4 3d MTOR V2006 2006 479 4jsp_B(0.0472);4jsp_A(0.0485);4jsn_B(0.0514);4jsn_A(0.0468);4jsx_B(0.0487);4jsx_A(0.0519);4jsv_B(0.0508);4jt6_B(0.0481);4jsv_A(0.0505);4jt6_A(0.051);4jt5_B(0.0513);4jt5_A(0.0487) Cluster-exclusive I:1|L:1 0.0468 2 2 ucec:1|kirc:1 ENST00000361445 4 3d ACTA2 E109 109 481 2yjf_D(0.0497);2yjf_A(0.053);2yjf_C(0.049);2yje_C(0.0529);2v51_D(0.0575);1ijj_A(0.0489);1ijj_B(0.0547);1lcu_B(0.0469);4m63_D(0.0892);4m63_C(0.0903);3m1f_A(0.0518);1h1v_A(0.0601);3b63_D(0.0663);3b63_E(0.0577);1y64_A(0.0478);3m3n_A(0.0484);3m3n_B(0.0503) Cluster-exclusive D:2 0.0469 2 1 coadread:2 ENST00000224784 6 3d ACTA2 K115 115 481 2yjf_D(0.0497);2yjf_A(0.053);2yjf_C(0.049);2yje_C(0.0529);2v51_D(0.0575);1ijj_A(0.0489);1ijj_B(0.0547);1lcu_B(0.0469);4m63_D(0.0892);4m63_C(0.0903);3m1f_A(0.0518);1h1v_A(0.0601);3b63_D(0.0663);3b63_E(0.0577);1y64_A(0.0478);3m3n_A(0.0484);3m3n_B(0.0503) Cluster-exclusive N:1 0.0469 1 1 ucec:1 ENST00000224784 6 3d ACTA2 N117 117 481 2yjf_D(0.0497);2yjf_A(0.053);2yjf_C(0.049);2yje_C(0.0529);2v51_D(0.0575);1ijj_A(0.0489);1ijj_B(0.0547);1lcu_B(0.0469);4m63_D(0.0892);4m63_C(0.0903);3m1f_A(0.0518);1h1v_A(0.0601);3b63_D(0.0663);3b63_E(0.0577);1y64_A(0.0478);3m3n_A(0.0484);3m3n_B(0.0503) Cluster-exclusive D:1 0.0469 1 1 skcm:1 ENST00000224784 6 3d ACTA2 R118 118 481 2yjf_D(0.0497);2yjf_A(0.053);2yjf_C(0.049);2yje_C(0.0529);2v51_D(0.0575);1ijj_A(0.0489);1ijj_B(0.0547);1lcu_B(0.0469);4m63_D(0.0892);4m63_C(0.0903);3m1f_A(0.0518);1h1v_A(0.0601);3b63_D(0.0663);3b63_E(0.0577);1y64_A(0.0478);3m3n_A(0.0484);3m3n_B(0.0503) Cluster-exclusive Q:2 0.0469 2 2 gbm:1|hnsc:1 ENST00000224784 6 3d ACTA2 Q123 123 481 2yjf_D(0.0497);2yjf_A(0.053);2yjf_C(0.049);2yje_C(0.0529);2v51_D(0.0575);1ijj_A(0.0489);1ijj_B(0.0547);1lcu_B(0.0469);4m63_D(0.0892);4m63_C(0.0903);3m1f_A(0.0518);1h1v_A(0.0601);3b63_D(0.0663);3b63_E(0.0577);1y64_A(0.0478);3m3n_A(0.0484);3m3n_B(0.0503) Cluster-exclusive E:1|H:1 0.0469 2 2 brca:1|stad:1 ENST00000224784 6 3d ADCY5 I470 470 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive T:1 0.0472 1 1 lihc:1 ENST00000462833 1 3d ADCY5 A487 487 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive T:1 0.0472 1 1 stad:1 ENST00000462833 1 3d ADCY5 Q488 488 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive E:1 0.0472 1 1 prad:1 ENST00000462833 1 3d ADCY5 E496 496 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive K:1 0.0472 1 1 cscc:1 ENST00000462833 1 3d ADCY5 A499 499 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive T:2 0.0472 2 2 coadread:1|cesc:1 ENST00000462833 1 3d ADCY5 D502 502 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive G:1 0.0472 1 1 cscc:1 ENST00000462833 1 3d ADCY5 G598 598 483 1ssp_E(0.0638);2oxm_A(0.0553);2ssp_E(0.0629);3fci_A(0.0498);2hxm_A(0.0518);4skn_E(0.0472);1q3f_A(0.0546);3fcf_A(0.0489);1emj_A(0.0546);2oyt_A(0.0536);3fcl_A(0.0515);1emh_A(0.0543) Cluster-exclusive C:2|D:1 0.0472 3 3 coadread:1|hnsc:1|luad:1 ENST00000462833 1 3d RBM46 R271 271 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive K:1 0.0473 1 1 skcm:1 ENST00000281722 3 3d RBM46 D272 272 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive N:1 0.0473 1 1 skcm:1 ENST00000281722 3 3d RBM46 A274 274 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive V:1 0.0473 1 1 skcm:1 ENST00000281722 3 3d RBM46 F275 275 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive S:1 0.0473 1 1 gbm:1 ENST00000281722 3 3d RBM46 E282 282 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive K:1 0.0473 1 1 lusc:1 ENST00000281722 3 3d RBM46 R316 316 484 3coi_A(0.0493);4eym_A(0.0493);4eyj_A(0.0473) Cluster-exclusive K:1 0.0473 1 1 skcm:1 ENST00000281722 3 3d SLC25A11 S201 201 485 1ksj_A(0.0613);3doe_A(0.0915);3dof_A(0.084);1ksh_A(0.0734);1ksg_A(0.0757);4gok_B(0.0473);4gok_A(0.0482) Cluster-exclusive F:1 0.0473 1 1 lihc:1 ENST00000225665 7 3d SLC25A11 Y259 259 485 1ksj_A(0.0613);3doe_A(0.0915);3dof_A(0.084);1ksh_A(0.0734);1ksg_A(0.0757);4gok_B(0.0473);4gok_A(0.0482) Cluster-exclusive C:1 0.0473 1 1 brca:1 ENST00000225665 7 3d SLC25A11 K260 260 485 1ksj_A(0.0613);3doe_A(0.0915);3dof_A(0.084);1ksh_A(0.0734);1ksg_A(0.0757);4gok_B(0.0473);4gok_A(0.0482) Cluster-exclusive N:1 0.0473 1 1 gbm:1 ENST00000225665 7 3d SLC25A11 N261 261 485 1ksj_A(0.0613);3doe_A(0.0915);3dof_A(0.084);1ksh_A(0.0734);1ksg_A(0.0757);4gok_B(0.0473);4gok_A(0.0482) Cluster-exclusive T:1 0.0473 1 1 luad:1 ENST00000225665 7 3d SLC25A11 V265 265 485 1ksj_A(0.0613);3doe_A(0.0915);3dof_A(0.084);1ksh_A(0.0734);1ksg_A(0.0757);4gok_B(0.0473);4gok_A(0.0482) Cluster-exclusive M:1 0.0473 1 1 blca:1 ENST00000225665 7 3d GUCY1B1 R40 40 486 4lot_A(0.0473) Cluster-exclusive T:1 0.0473 1 1 luad:1 ENST00000264424 8 3d GUCY1B1 I41 41 486 4lot_A(0.0473) Cluster-exclusive L:1 0.0473 1 1 ucec:1 ENST00000264424 8 3d GUCY1B1 A55 55 486 4lot_A(0.0473) Cluster-exclusive T:1 0.0473 1 1 lihc:1 ENST00000264424 8 3d GUCY1B1 S56 56 486 4lot_A(0.0473) Cluster-exclusive C:1 0.0473 1 1 luad:1 ENST00000264424 8 3d GUCY1B1 K57 57 486 4lot_A(0.0473) Cluster-exclusive N:1 0.0473 1 1 stad:1 ENST00000264424 8 3d PLEKHA6 D86 86 487 2yry_A(0.0474) Cluster-exclusive V:1|N:1 0.0474 2 2 skcm:1|kirp:1 ENST00000272203 3 3d PLEKHA6 G102 102 487 2yry_A(0.0474) Cluster-exclusive D:1 0.0474 1 1 stad:1 ENST00000272203 3 3d CCL7 F38 38 488 1bo0_A(0.0475) Cluster-exclusive I:1 0.0475 1 1 ov:1 ENST00000378569 2 3d CCL7 R53 53 488 1bo0_A(0.0475) Cluster-exclusive K:2 0.0475 2 2 skcm:1|cscc:1 ENST00000378569 2 3d CCL7 R61 61 488 1bo0_A(0.0475) Cluster-exclusive W:3 0.0475 3 2 coadread:2|skcm:1 ENST00000378569 2 3d CCL7 A63 63 488 1bo0_A(0.0475) Cluster-exclusive D:1 0.0475 1 1 gbm:1 ENST00000378569 2 3d CCL7 I65 65 488 1bo0_A(0.0475) Cluster-exclusive L:1 0.0475 1 1 skcm:1 ENST00000378569 2 3d CCL7 A76 76 488 1bo0_A(0.0475) Cluster-exclusive T:1 0.0475 1 1 lusc:1 ENST00000378569 2 3d CCL7 D77 77 488 1bo0_A(0.0475) Cluster-exclusive Y:1 0.0475 1 1 ucec:1 ENST00000378569 2 3d ECHDC3 A86 86 489 2vx2_C(0.052);2vx2_E(0.0478);2vx2_F(0.0544) Cluster-exclusive T:1 0.0478 1 1 stad:1 ENST00000379215 4 3d ECHDC3 H138 138 489 2vx2_C(0.052);2vx2_E(0.0478);2vx2_F(0.0544) Cluster-exclusive D:1 0.0478 1 1 kirc:1 ENST00000379215 4 3d ECHDC3 V140 140 489 2vx2_C(0.052);2vx2_E(0.0478);2vx2_F(0.0544) Cluster-exclusive I:1 0.0478 1 1 cll:1 ENST00000379215 4 3d ECHDC3 D162 162 489 2vx2_C(0.052);2vx2_E(0.0478);2vx2_F(0.0544) Cluster-exclusive G:1 0.0478 1 1 mmyl:1 ENST00000379215 4 3d ECHDC3 S249 249 489 2vx2_C(0.052);2vx2_E(0.0478);2vx2_F(0.0544) Cluster-exclusive F:1 0.0478 1 1 skcm:1 ENST00000379215 4 3d C3 M479 479 490 3l5n_A(0.0479) Cluster-exclusive T:1 0.0479 1 1 lihc:1 ENST00000245907 6 3d C3 R481 481 490 3l5n_A(0.0479) Cluster-exclusive H:1 0.0479 1 1 gbm:1 ENST00000245907 6 3d C3 A482 482 490 3l5n_A(0.0479) Cluster-exclusive T:3 0.0479 3 1 stad:3 ENST00000245907 6 3d C3 E484 484 490 3l5n_A(0.0479) Cluster-exclusive D:1|K:1 0.0479 2 2 brca:1|skcm:1 ENST00000245907 6 3d C3 R508 508 490 3l5n_A(0.0479) Cluster-exclusive Q:1|L:1 0.0479 2 2 hnsc:1|skcm:1 ENST00000245907 6 3d C3 D513 513 490 3l5n_A(0.0479) Cluster-exclusive N:1 0.0479 1 1 skcm:1 ENST00000245907 6 3d H4C5 K92 92 491 1hio_D(0.0481) Cluster-exclusive N:1 0.0481 1 1 coadread:1 ENST00000360441 4 3d H4C5 R93 93 491 1hio_D(0.0481) Cluster-exclusive T:3 0.0481 3 3 hnsc:1|lusc:1|cesc:1 ENST00000360441 4 3d H4C5 G95 95 491 1hio_D(0.0481) Cluster-exclusive R:1|E:1 0.0481 2 2 hnsc:1|skcm:1 ENST00000360441 4 3d H3C13 K123 123 492 1hio_C(0.0481) Cluster-exclusive N:1 0.0481 1 1 brca:1 ENST00000331491 1 3d H3C13 D124 124 492 1hio_C(0.0481) Cluster-exclusive Y:1 0.0481 1 1 brca:1 ENST00000331491 1 3d H3C13 I125 125 492 1hio_C(0.0481) Cluster-exclusive V:1 0.0481 1 1 hnsc:1 ENST00000331491 1 3d H3C13 L127 127 492 1hio_C(0.0481) Cluster-exclusive F:1 0.0481 1 1 coadread:1 ENST00000331491 1 3d H3C13 R130 130 493 1hio_C(0.0481) Cluster-exclusive C:1 0.0481 1 1 brca:1 ENST00000331491 1 3d PRELID1 Q24 24 494 2hgs_A(0.0483) Cluster-exclusive K:1 0.0483 1 1 kirc:1 ENST00000303204 4 3d PRELID1 S52 52 494 2hgs_A(0.0483) Cluster-exclusive F:1 0.0483 1 1 skcm:1 ENST00000303204 4 3d PRELID1 R53 53 494 2hgs_A(0.0483) Cluster-exclusive Q:1 0.0483 1 1 prad:1 ENST00000303204 4 3d CR1L S349 349 496 2q7z_A(0.0484) Cluster-exclusive Y:1 0.0484 1 1 lusc:1 ENST00000508064 2 3d CR1L C350 350 496 2q7z_A(0.0484) Cluster-exclusive S:1 0.0484 1 1 esca:1 ENST00000508064 2 3d CR1L Q369 369 496 2q7z_A(0.0484) Cluster-exclusive R:1 0.0484 1 1 stad:1 ENST00000508064 2 3d CR1L L370 370 496 2q7z_A(0.0484) Cluster-exclusive H:1 0.0484 1 1 luad:1 ENST00000508064 2 3d PYGM S461 461 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive F:1 0.0485 1 1 skcm:1 ENST00000164139 3 3d PYGM Q481 481 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive H:1 0.0485 1 1 ucec:1 ENST00000164139 3 3d PYGM K483 483 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive N:1 0.0485 1 1 lusm:1 ENST00000164139 3 3d PYGM T484 484 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive I:1 0.0485 1 1 skcm:1 ENST00000164139 3 3d PYGM R816 816 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive G:1 0.0485 1 1 ov:1 ENST00000164139 3 3d PYGM T817 817 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive A:1 0.0485 1 1 hnsc:1 ENST00000164139 3 3d PYGM Y821 821 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive H:1 0.0485 1 1 kirc:1 ENST00000164139 3 3d PYGM E824 824 498 3e3l_C(0.0485);3ms4_A(0.0578);3e3l_B(0.0539);3e3l_A(0.0543);3cuv_A(0.0618);3g2j_A(0.0705);2skd_A(0.058);2pri_A(0.0591);2gpn_A(0.0628);1fu7_A(0.0593);1h5u_A(0.0546);2g9u_A(0.0577);1z62_A(0.0588);1a8i_A(0.0627);3mqf_A(0.0561);2gm9_A(0.0676);2iei_A(0.061);2g9q_A(0.0578);1fs4_A(0.0615);2iei_B(0.059);3g2n_A(0.0596);3bcr_A(0.0574);1hlf_A(0.0622);2gpb_A(0.0559);2ff5_A(0.0627);2ffr_A(0.0594);3mrx_A(0.057);3e3l_D(0.0543);3mrt_A(0.0626);1noi_A(0.0586);3amv_A(0.0645);1ftw_A(0.0622);1pyg_A(0.0528);3gpb_A(0.0601);3l79_A(0.0556);3np9_A(0.0626);1pyg_B(0.0572);2qn9_A(0.0542);3l7b_A(0.0551);1k06_A(0.0603);1p2g_A(0.0578);3zcu_A(0.0575);1p4j_A(0.0563);2qn1_A(0.0618);3bd6_A(0.0596);2fet_A(0.0628);1e1y_A(0.0625);3zcq_A(0.0564);2pyd_A(0.0644);1wv0_A(0.0607);3cuu_A(0.063);2ske_A(0.0587);3g2k_A(0.0603);1ggn_A(0.0617);1fu4_A(0.0599);1fu8_A(0.0589);4el0_A(0.0558);1z6p_A(0.0691);1p2d_A(0.0579);2f3u_A(0.0635);5gpb_A(0.0592);1b4d_A(0.0667);3bcu_A(0.0557);2gpa_A(0.0576);3e3o_D(0.0521);2f3q_A(0.0557);3mt9_A(0.0585);3e3o_C(0.0553);3e3o_B(0.0536);3e3o_A(0.055);1ww2_A(0.0536);1c8l_A(0.0639);1noj_A(0.0634);1wut_A(0.0573);3s0j_A(0.0588);2gj4_A(0.053);1abb_A(0.0575);3zcv_A(0.0575);1lwn_A(0.0552);1p4g_A(0.0617);3zcr_A(0.0545);2qrg_A(0.0549);2qn8_A(0.0549);3l7a_A(0.0572);3mtb_A(0.0582);3t3e_A(0.0574);3t3i_A(0.056);2qln_A(0.0556);2qrq_A(0.0664);3cut_A(0.0575);3e3n_A(0.0553);4el5_A(0.0559);1wv1_A(0.0558);3g2h_A(0.0686);4ej2_A(0.0586);3ms2_A(0.0688);1xl0_A(0.0592);1z6q_A(0.0619);8gpb_A(0.059);3nc4_A(0.0583);3msc_A(0.058);2ieg_A(0.0646);3bda_A(0.0539);1gfz_A(0.0612);2ieg_B(0.0642);3e3n_H(0.0539);3g2l_A(0.0619);2f3p_A(0.0639);3e3n_F(0.0575);1gpy_A(0.0638);3e3n_E(0.0547);3mt8_A(0.0606);3mrv_A(0.058);4eky_A(0.0602);3e3n_D(0.055);3e3n_C(0.0572);3e3n_B(0.056);1axr_A(0.0673);6gpb_A(0.064);1nok_A(0.0544);1ftq_A(0.0592);3ebo_A(0.0558);1ww3_A(0.0586);1c8k_A(0.054);1fty_A(0.0649);1wuy_A(0.0541);3np7_A(0.0595);3syr_A(0.056);4eke_A(0.0572);1lwo_A(0.057);1k08_A(0.0576);1gpa_A(0.0545);3zcs_A(0.0559);3mta_A(0.0587);1p4h_A(0.0606);3t3d_A(0.06);2qrh_A(0.0652);2qn7_A(0.0582);1bx3_A(0.0636);1z8d_A(0.0708);3t3h_A(0.059);2qn3_A(0.0549);3l7d_A(0.0528);1xc7_A(0.0502);1xkx_A(0.0607);3ms7_A(0.0565);2qrp_A(0.0684);3bd8_A(0.058);2qlm_A(0.0565);2skc_A(0.0585);1xl1_A(0.0645);3cuw_A(0.0602);1c50_A(0.0602);2amv_A(0.0732);3g2i_A(0.0658);3npa_A(0.0571);2g9r_A(0.0606);2prj_A(0.0561);2qnb_A(0.0543);2g9v_A(0.0609);1p2b_A(0.0544);3bcs_A(0.0605);2f3s_A(0.0624);2off_A(0.0543);3sym_A(0.0601);3mt7_A(0.0647);2pyi_A(0.0659);1kti_A(0.0572);1uzu_A(0.0605);3ebp_A(0.0567);3mtd_A(0.0575);1gg8_A(0.0562);3l7c_A(0.0572);3t3g_A(0.0589);1p29_A(0.0561);1gpb_A(0.0637);3zct_A(0.0581);2qn2_A(0.0567);3zcp_A(0.0588);4gpb_A(0.0604);2qrm_A(0.0549);7gpb_A(0.0606);3bd7_A(0.0581) Cluster-exclusive D:1|K:1 0.0485 2 2 skcm:1|luad:1 ENST00000164139 3 3d MAPK1 Y316 316 499 4erk_A(0.0578);4iza_C(0.052);4h3p_A(0.0486) Hotspot-linked F:1 0.0486 1 1 cll:1 ENST00000215832 6 3d EPHA1 S452 452 500 1x5a_A(0.0486) Cluster-exclusive C:1 0.0486 1 1 luad:1 ENST00000275815 3 3d EPHA1 L453 453 500 1x5a_A(0.0486) Cluster-exclusive Q:1 0.0486 1 1 coadread:1 ENST00000275815 3 3d EPHA1 V514 514 500 1x5a_A(0.0486) Cluster-exclusive I:2 0.0486 2 2 mmyl:1|lusm:1 ENST00000275815 3 3d EPHA1 R517 517 500 1x5a_A(0.0486) Cluster-exclusive Q:2 0.0486 2 2 blca:1|skcm:1 ENST00000275815 3 3d EPHA1 F527 527 500 1x5a_A(0.0486) Cluster-exclusive L:1 0.0486 1 1 brca:1 ENST00000275815 3 3d EPHA1 S528 528 500 1x5a_A(0.0486) Cluster-exclusive F:1 0.0486 1 1 skcm:1 ENST00000275815 3 3d EPHA1 P529 529 500 1x5a_A(0.0486) Cluster-exclusive L:1 0.0486 1 1 skcm:1 ENST00000275815 3 3d OXSM A347 347 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive T:1 0.0486 1 1 coadread:1 ENST00000280701 3 3d OXSM A389 389 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive V:1 0.0486 1 1 stad:1 ENST00000280701 3 3d OXSM G391 391 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive W:1 0.0486 1 1 luad:1 ENST00000280701 3 3d OXSM V393 393 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive F:1 0.0486 1 1 lihc:1 ENST00000280701 3 3d OXSM E394 394 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive K:1 0.0486 1 1 blca:1 ENST00000280701 3 3d OXSM T442 442 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive A:1 0.0486 1 1 lihc:1 ENST00000280701 3 3d OXSM N443 443 501 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwy_B(0.0486);2iwz_A(0.0509) Cluster-exclusive S:1 0.0486 1 1 hnsc:1 ENST00000280701 3 3d OXSM G212 212 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive R:1 0.0486 1 1 coadread:1 ENST00000280701 3 3d OXSM A213 213 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive T:1 0.0486 1 1 lihc:1 ENST00000280701 3 3d WDR75 F506 506 503 1bhg_A(0.0527);3hn3_E(0.0486);3hn3_D(0.0542);3hn3_B(0.051);3hn3_A(0.0536) Cluster-exclusive L:1 0.0486 1 1 gbm:1 ENST00000314761 4 3d WDR75 S507 507 503 1bhg_A(0.0527);3hn3_E(0.0486);3hn3_D(0.0542);3hn3_B(0.051);3hn3_A(0.0536) Cluster-exclusive F:1 0.0486 1 1 skcm:1 ENST00000314761 4 3d WDR75 E508 508 503 1bhg_A(0.0527);3hn3_E(0.0486);3hn3_D(0.0542);3hn3_B(0.051);3hn3_A(0.0536) Cluster-exclusive K:1 0.0486 1 1 gbm:1 ENST00000314761 4 3d WDR75 S511 511 503 1bhg_A(0.0527);3hn3_E(0.0486);3hn3_D(0.0542);3hn3_B(0.051);3hn3_A(0.0536) Cluster-exclusive F:1|Y:1 0.0486 2 1 coadread:2 ENST00000314761 4 3d ACVR1B H333 333 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive R:1 0.0487 1 1 coadread:1 ENST00000257963 4 3d ACVR1B D335 335 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive G:1|N:1 0.0487 2 2 coadread:1|cesc:1 ENST00000257963 4 3d ACVR1B F398 398 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive C:1 0.0487 1 1 hnsc:1 ENST00000257963 4 3d TICAM1 E105 105 505 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive Q:1 0.0488 1 1 brca:1 ENST00000248244 5 3d EHMT1 L777 777 506 3b95_B(0.0489) Cluster-exclusive R:1 0.0489 1 1 brca:1 ENST00000460843 1 3d EHMT1 A780 780 506 3b95_B(0.0489) Cluster-exclusive T:1 0.0489 1 1 stad:1 ENST00000460843 1 3d EHMT1 A797 797 506 3b95_B(0.0489) Cluster-exclusive T:1|V:1 0.0489 2 2 ucec:1|luad:1 ENST00000460843 1 3d EHMT1 N798 798 506 3b95_B(0.0489) Cluster-exclusive D:1 0.0489 1 1 esca:1 ENST00000460843 1 3d EHMT1 T801 801 506 3b95_B(0.0489) Cluster-exclusive I:1 0.0489 1 1 stad:1 ENST00000460843 1 3d EHMT1 P809 809 506 3b95_B(0.0489) Cluster-exclusive L:1 0.0489 1 1 lusc:1 ENST00000460843 1 3d RNF41 A209 209 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive V:1 0.049 1 1 ucec:1 ENST00000345093 4 3d RNF41 A277 277 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive T:1 0.049 1 1 gbm:1 ENST00000345093 4 3d RNF41 R279 279 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive H:1 0.049 1 1 stad:1 ENST00000345093 4 3d RNF41 P281 281 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive S:2 0.049 2 2 skcm:1|cscc:1 ENST00000345093 4 3d RNF41 E315 315 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive Q:1 0.049 1 1 luad:1 ENST00000345093 4 3d RNF41 E316 316 508 2gwf_B(0.049);2fzp_A(0.0548);2gwf_D(0.0504);2gwf_F(0.0655) Cluster-exclusive D:1 0.049 1 1 ucec:1 ENST00000345093 4 3d EIF1AX G8 8 509 1d7q_A(0.0494) Cluster-exclusive R:1|E:1 0.0494 2 2 thca:1|cesc:1 ENST00000379607 5 3d EIF1AX G9 9 509 1d7q_A(0.0494) Cluster-exclusive R:1|D:3 0.0494 4 2 thca:3|hnsc:1 ENST00000379607 5 3d EIF1AX K10 10 509 1d7q_A(0.0494) Cluster-exclusive E:2 0.0494 2 2 skcm:1|lgg:1 ENST00000379607 5 3d EIF1AX R12 12 509 1d7q_A(0.0494) Cluster-exclusive G:1 0.0494 1 1 skcm:1 ENST00000379607 5 3d EIF1AX R13 13 509 1d7q_A(0.0494) Cluster-exclusive H:3 0.0494 3 2 ucec:2|lgg:1 ENST00000379607 5 3d TUBA3D H406 406 510 4ffb_A(0.0494) Cluster-exclusive Q:1 0.0494 1 1 luad:1 ENST00000321253 6 3d TUBA3D E415 415 510 4ffb_A(0.0494) Cluster-exclusive K:1 0.0494 1 1 stad:1 ENST00000321253 6 3d HGFAC P453 453 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive S:1 0.0495 1 1 skcm:1 ENST00000382774 3 3d HGFAC P454 454 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive S:1|L:1 0.0495 2 2 skcm:1|cscc:1 ENST00000382774 3 3d HGFAC R455 455 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive T:1 0.0495 1 1 luad:1 ENST00000382774 3 3d HGFAC V458 458 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive I:1 0.0495 1 1 gbm:1 ENST00000382774 3 3d HGFAC S459 459 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive F:1 0.0495 1 1 skcm:1 ENST00000382774 3 3d HGFAC V460 460 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive M:1 0.0495 1 1 stad:1 ENST00000382774 3 3d HGFAC G478 478 511 1yc0_A(0.0918);1ybw_B(0.0546);1ybw_A(0.0495) Cluster-exclusive D:1 0.0495 1 1 stad:1 ENST00000382774 3 3d PIK3R1 Y580 580 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Cluster-exclusive C:1|D:1 0.0497 2 2 gbm:1|ucec:1 ENST00000274335 5 3d ZNF664 L186 186 513 3ei4_B(0.0499) Cluster-exclusive I:1 0.0499 1 1 cesc:1 ENST00000337815 4 3d ZNF664 R191 191 513 3ei4_B(0.0499) Cluster-exclusive T:1 0.0499 1 1 luad:1 ENST00000337815 4 3d ZNF664 E196 196 513 3ei4_B(0.0499) Cluster-exclusive K:1 0.0499 1 1 lusc:1 ENST00000337815 4 3d ZNF664 P198 198 513 3ei4_B(0.0499) Cluster-exclusive F:1 0.0499 1 1 skcm:1 ENST00000337815 4 3d ZNF664 A207 207 513 3ei4_B(0.0499) Cluster-exclusive S:1 0.0499 1 1 coadread:1 ENST00000337815 4 3d ZNF664 R219 219 513 3ei4_B(0.0499) Cluster-exclusive I:1|K:1 0.0499 2 1 coadread:2 ENST00000337815 4 3d MMEL1 R126 126 514 2aow_A(0.0499);2aov_A(0.0534);2aou_B(0.0643);1jqd_A(0.0573);1jqd_B(0.0593);1jqe_A(0.0667);2aot_B(0.0594);2aou_A(0.0649);2aot_A(0.07) Cluster-exclusive H:1 0.0499 1 1 coadread:1 ENST00000378412 3 3d MMEL1 V128 128 514 2aow_A(0.0499);2aov_A(0.0534);2aou_B(0.0643);1jqd_A(0.0573);1jqd_B(0.0593);1jqe_A(0.0667);2aot_B(0.0594);2aou_A(0.0649);2aot_A(0.07) Cluster-exclusive M:1 0.0499 1 1 coadread:1 ENST00000378412 3 3d MMEL1 E131 131 514 2aow_A(0.0499);2aov_A(0.0534);2aou_B(0.0643);1jqd_A(0.0573);1jqd_B(0.0593);1jqe_A(0.0667);2aot_B(0.0594);2aou_A(0.0649);2aot_A(0.07) Cluster-exclusive Q:2|K:1 0.0499 3 3 brca:1|ucs:1|hnsc:1 ENST00000378412 3 3d MMEL1 D140 140 514 2aow_A(0.0499);2aov_A(0.0534);2aou_B(0.0643);1jqd_A(0.0573);1jqd_B(0.0593);1jqe_A(0.0667);2aot_B(0.0594);2aou_A(0.0649);2aot_A(0.07) Cluster-exclusive N:1 0.0499 1 1 skcm:1 ENST00000378412 3 3d MMEL1 G185 185 514 2aow_A(0.0499);2aov_A(0.0534);2aou_B(0.0643);1jqd_A(0.0573);1jqd_B(0.0593);1jqe_A(0.0667);2aot_B(0.0594);2aou_A(0.0649);2aot_A(0.07) Cluster-exclusive V:1 0.0499 1 1 luad:1 ENST00000378412 3 3d GATA1 R270 270 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive W:1 0.0499 1 1 stad:1 ENST00000376670 3 3d GATA1 P277 277 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive S:1 0.0499 1 1 luad:1 ENST00000376670 3 3d GATA1 V278 278 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive M:1 0.0499 1 1 coadread:1 ENST00000376670 3 3d GATA1 C279 279 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive F:1 0.0499 1 1 ucec:1 ENST00000376670 3 3d GATA1 G283 283 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive 0.0499 1 ENST00000376670 3 3d GATA1 L284 284 515 3vek_C(0.0499);3vd6_C(0.0541) Cluster-exclusive I:1 0.0499 1 1 lusm:1 ENST00000376670 3 3d RORC F377 377 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive Y:1 0.05 1 1 skcm:1 ENST00000318247 6 3d RORC S398 398 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive N:1 0.05 1 1 stad:1 ENST00000318247 6 3d RORC F388 388 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive L:1 0.05 1 1 skcm:1 ENST00000318247 6 3d CFL1 V14 14 519 1q8g_A(0.0501) Cluster-exclusive G:1 0.0501 1 1 brca:1 ENST00000308162 5 3d CFL1 F15 15 519 1q8g_A(0.0501) Cluster-exclusive L:1 0.0501 1 1 stad:1 ENST00000308162 5 3d CFL1 M18 18 519 1q8g_A(0.0501) Cluster-exclusive L:2 0.0501 2 2 hnsc:1|lihc:1 ENST00000308162 5 3d CFL1 R21 21 519 1q8g_A(0.0501) Cluster-exclusive H:1 0.0501 1 1 coadread:1 ENST00000308162 5 3d CFL1 K34 34 519 1q8g_A(0.0501) Cluster-exclusive R:1 0.0501 1 1 stad:1 ENST00000308162 5 3d CFL1 V36 36 519 1q8g_A(0.0501) Cluster-exclusive M:1 0.0501 1 1 stad:1 ENST00000308162 5 3d CFL1 D86 86 519 1q8g_A(0.0501) Cluster-exclusive G:1 0.0501 1 1 cll:1 ENST00000308162 5 3d DNM2 R256 256 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive G:1 0.0501 1 1 lihc:1 ENST00000355667 6 3d DNM2 L260 260 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive F:1 0.0501 1 1 skcm:1 ENST00000355667 6 3d DNM2 A269 269 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive V:1 0.0501 1 1 coadread:1 ENST00000355667 6 3d DNM2 D270 270 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive N:1 0.0501 1 1 esca:1 ENST00000355667 6 3d DNM2 R271 271 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive L:1 0.0501 1 1 hnsc:1 ENST00000355667 6 3d DNM2 G273 273 520 3l43_B(0.0501);3l43_A(0.0547) Cluster-exclusive S:1 0.0501 1 1 cscc:1 ENST00000355667 6 3d CAPNS1 R145 145 521 1qxp_A(0.0568);1qxp_B(0.0501) Cluster-exclusive C:1|H:1 0.0501 2 2 stad:1|skcm:1 ENST00000246533 3 3d CAPNS1 S146 146 521 1qxp_A(0.0568);1qxp_B(0.0501) Cluster-exclusive N:1 0.0501 1 1 skcm:1 ENST00000246533 3 3d CAPNS1 M147 147 521 1qxp_A(0.0568);1qxp_B(0.0501) Cluster-exclusive I:1 0.0501 1 1 luad:1 ENST00000246533 3 3d CAPNS1 S268 268 521 1qxp_A(0.0568);1qxp_B(0.0501) Cluster-exclusive F:1 0.0501 1 1 cesc:1 ENST00000246533 3 3d FGFR3 R248 248 522 3grw_A(0.0796);1ry7_B(0.0502) Hotspot C:9 0.0502 9 4 mmyl:1|blca:6|hnsc:1|lusc:1 ENST00000260795 2 3d FGFR3 S249 249 522 3grw_A(0.0796);1ry7_B(0.0502) Hotspot C:18 0.0502 18 4 blca:11|hnsc:4|lusc:2|kirp:1 ENST00000260795 2 3d FGFR3 P250 250 522 3grw_A(0.0796);1ry7_B(0.0502) Hotspot-linked S:1 0.0502 1 1 hnsc:1 ENST00000260795 2 3d FGFR3 D280 280 522 3grw_A(0.0796);1ry7_B(0.0502) Hotspot-linked G:1|N:1 0.0502 2 2 lymbc:1|luad:1 ENST00000260795 2 3d TRPV1 G225 225 527 2wa0_A(0.0506) Cluster-exclusive R:1 0.0506 1 1 paad:1 ENST00000399756 4 3d TRPV1 Q229 229 527 2wa0_A(0.0506) Cluster-exclusive H:1 0.0506 1 1 paad:1 ENST00000399756 4 3d TRPV1 V222 222 528 2wa0_A(0.0506) Cluster-exclusive M:1 0.0506 1 1 ov:1 ENST00000399756 4 3d TRPV1 D227 227 528 2wa0_A(0.0506) Cluster-exclusive N:1 0.0506 1 1 lusc:1 ENST00000399756 4 3d TRPV1 A231 231 528 2wa0_A(0.0506) Cluster-exclusive V:1 0.0506 1 1 gbm:1 ENST00000399756 4 3d PLG V692 692 529 3uir_A(0.0698);1l4d_A(0.0534);1bml_B(0.0555);1bml_A(0.0527);3uir_B(0.0675);1rjx_B(0.0528);1l4z_A(0.0543);1ddj_C(0.0566);1ddj_B(0.0535);1bui_B(0.0528);1ddj_D(0.0506);1ddj_A(0.0578);1bui_A(0.0546) Cluster-exclusive A:1 0.0506 1 1 stad:1 ENST00000308192 9 3d PLG S741 741 529 3uir_A(0.0698);1l4d_A(0.0534);1bml_B(0.0555);1bml_A(0.0527);3uir_B(0.0675);1rjx_B(0.0528);1l4z_A(0.0543);1ddj_C(0.0566);1ddj_B(0.0535);1bui_B(0.0528);1ddj_D(0.0506);1ddj_A(0.0578);1bui_A(0.0546) Cluster-exclusive P:1 0.0506 1 1 lihc:1 ENST00000308192 9 3d PLG E743 743 529 3uir_A(0.0698);1l4d_A(0.0534);1bml_B(0.0555);1bml_A(0.0527);3uir_B(0.0675);1rjx_B(0.0528);1l4z_A(0.0543);1ddj_C(0.0566);1ddj_B(0.0535);1bui_B(0.0528);1ddj_D(0.0506);1ddj_A(0.0578);1bui_A(0.0546) Cluster-exclusive K:1 0.0506 1 1 cscc:1 ENST00000308192 9 3d PLG Q775 775 529 3uir_A(0.0698);1l4d_A(0.0534);1bml_B(0.0555);1bml_A(0.0527);3uir_B(0.0675);1rjx_B(0.0528);1l4z_A(0.0543);1ddj_C(0.0566);1ddj_B(0.0535);1bui_B(0.0528);1ddj_D(0.0506);1ddj_A(0.0578);1bui_A(0.0546) Cluster-exclusive R:1 0.0506 1 1 lihc:1 ENST00000308192 9 3d PLG R795 795 529 3uir_A(0.0698);1l4d_A(0.0534);1bml_B(0.0555);1bml_A(0.0527);3uir_B(0.0675);1rjx_B(0.0528);1l4z_A(0.0543);1ddj_C(0.0566);1ddj_B(0.0535);1bui_B(0.0528);1ddj_D(0.0506);1ddj_A(0.0578);1bui_A(0.0546) Cluster-exclusive H:1 0.0506 1 1 ucec:1 ENST00000308192 9 3d OXSR1 T178 178 531 2vwi_C(0.0509) Cluster-exclusive A:1 0.0509 1 1 luad:1 ENST00000311806 3 3d OXSR1 R179 179 531 2vwi_C(0.0509) Cluster-exclusive Q:1 0.0509 1 1 coadread:1 ENST00000311806 3 3d OXSR1 M198 198 531 2vwi_C(0.0509) Cluster-exclusive T:1|V:1 0.0509 2 2 lihc:1|ucec:1 ENST00000311806 3 3d OXSR1 V201 201 531 2vwi_C(0.0509) Cluster-exclusive F:1 0.0509 1 1 ov:1 ENST00000311806 3 3d OXSR1 R202 202 531 2vwi_C(0.0509) Cluster-exclusive H:1 0.0509 1 1 cesc:1 ENST00000311806 3 3d MDGA2 K229 229 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive T:1 0.051 1 1 stad:1 ENST00000399232 2 3d MDGA2 M230 230 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive I:1 0.051 1 1 kirc:1 ENST00000399232 2 3d MDGA2 T266 266 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive I:1 0.051 1 1 lusc:1 ENST00000399232 2 3d MDGA2 G268 268 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive E:1 0.051 1 1 cscc:1 ENST00000399232 2 3d MDGA2 G269 269 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive E:1 0.051 1 1 cscc:1 ENST00000399232 2 3d MDGA2 S280 280 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive C:1 0.051 1 1 lusc:1 ENST00000399232 2 3d MDGA2 D303 303 534 3ze0_C(0.051);3zdz_C(0.0511) Cluster-exclusive N:1 0.051 1 1 skcm:1 ENST00000399232 2 3d KRT5 E385 385 535 3tnu_B(0.0511) Cluster-exclusive K:2 0.0511 2 2 brca:1|cscc:1 ENST00000252242 4 3d KRT5 S387 387 535 3tnu_B(0.0511) Cluster-exclusive P:1 0.0511 1 1 lihc:1 ENST00000252242 4 3d KRT5 E388 388 535 3tnu_B(0.0511) Cluster-exclusive D:1 0.0511 1 1 hnsc:1 ENST00000252242 4 3d KRT5 M389 389 535 3tnu_B(0.0511) Cluster-exclusive I:1 0.0511 1 1 hnsc:1 ENST00000252242 4 3d KRT5 M392 392 535 3tnu_B(0.0511) Cluster-exclusive I:3 0.0511 3 2 skcm:2|cscc:1 ENST00000252242 4 3d ETS2 K144 144 536 4mhv_A(0.0512);4mhv_B(0.055) Cluster-exclusive T:1|N:1 0.0512 2 2 coadread:1|skcm:1 ENST00000360214 3 3d ETS2 F147 147 536 4mhv_A(0.0512);4mhv_B(0.055) Cluster-exclusive L:1 0.0512 1 1 stad:1 ENST00000360214 3 3d ETS2 L148 148 536 4mhv_A(0.0512);4mhv_B(0.055) Cluster-exclusive P:1 0.0512 1 1 brca:1 ENST00000360214 3 3d ETS2 E149 149 536 4mhv_A(0.0512);4mhv_B(0.055) Cluster-exclusive D:1 0.0512 1 1 paad:1 ENST00000360214 3 3d ETS2 A151 151 536 4mhv_A(0.0512);4mhv_B(0.055) Cluster-exclusive T:1 0.0512 1 1 paad:1 ENST00000360214 3 3d KEAP1 G364 364 538 3wn7_A(0.0513) Cluster-exclusive C:1 0.0513 1 1 luad:1 ENST00000171111 5 3d KEAP1 G379 379 538 3wn7_A(0.0513) Cluster-exclusive V:1 0.0513 1 1 lihc:1 ENST00000171111 5 3d KEAP1 G509 509 538 3wn7_A(0.0513) Cluster-exclusive V:1|W:1 0.0513 2 1 luad:2 ENST00000171111 5 3d ZIC1 A314 314 539 2dmo_A(0.0513) Cluster-exclusive V:1|G:1 0.0513 2 2 lusc:1|luad:1 ENST00000282928 4 3d ZIC1 R315 315 539 2dmo_A(0.0513) Cluster-exclusive P:1|C:1 0.0513 2 2 stad:1|luad:1 ENST00000282928 4 3d ZIC1 S316 316 539 2dmo_A(0.0513) Cluster-exclusive C:2 0.0513 2 2 hnsc:1|luad:1 ENST00000282928 4 3d ZIC1 H326 326 539 2dmo_A(0.0513) Cluster-exclusive Q:1 0.0513 1 1 lusm:1 ENST00000282928 4 3d ZIC1 T327 327 539 2dmo_A(0.0513) Cluster-exclusive K:1 0.0513 1 1 luad:1 ENST00000282928 4 3d ZIC1 K330 330 539 2dmo_A(0.0513) Cluster-exclusive T:1 0.0513 1 1 stad:1 ENST00000282928 4 3d ZIC1 F332 332 539 2dmo_A(0.0513) Cluster-exclusive C:1 0.0513 1 1 lusc:1 ENST00000282928 4 3d ZIC1 K333 333 539 2dmo_A(0.0513) Cluster-exclusive N:1 0.0513 1 1 lihc:1 ENST00000282928 4 3d ZIC1 E317 317 540 2dmo_A(0.0513) Cluster-exclusive D:1 0.0513 1 1 mbl:1 ENST00000282928 4 3d CTCFL R301 301 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive Q:1|W:2 0.0515 3 3 brca:1|mmyl:1|stad:1 ENST00000243914 3 3d CTCFL T337 337 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive A:1 0.0515 1 1 ucs:1 ENST00000243914 3 3d CTCFL E339 339 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive K:1 0.0515 1 1 skcm:1 ENST00000243914 3 3d CTCFL G366 366 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive E:1 0.0515 1 1 kirc:1 ENST00000243914 3 3d CTCFL R368 368 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive H:2 0.0515 2 2 acc:1|coadread:1 ENST00000243914 3 3d CTCFL R380 380 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive T:1 0.0515 1 1 kirp:1 ENST00000243914 3 3d CTCFL D381 381 541 3l5j_A(0.0561);3l5h_A(0.0515) Cluster-exclusive H:1 0.0515 1 1 blca:1 ENST00000243914 3 3d CPB2 R183 183 542 3d67_B(0.0515);3d67_A(0.0605);3d68_C(0.0582);3d67_C(0.0616) Cluster-exclusive T:1 0.0515 1 1 brca:1 ENST00000181383 4 3d CPB2 R236 236 542 3d67_B(0.0515);3d67_A(0.0605);3d68_C(0.0582);3d67_C(0.0616) Cluster-exclusive Q:2 0.0515 2 2 stad:1|cscc:1 ENST00000181383 4 3d CPB2 W238 238 542 3d67_B(0.0515);3d67_A(0.0605);3d68_C(0.0582);3d67_C(0.0616) Cluster-exclusive R:1 0.0515 1 1 ucec:1 ENST00000181383 4 3d CPB2 G252 252 542 3d67_B(0.0515);3d67_A(0.0605);3d68_C(0.0582);3d67_C(0.0616) Cluster-exclusive E:2 0.0515 2 2 skcm:1|cscc:1 ENST00000181383 4 3d CPB2 E276 276 542 3d67_B(0.0515);3d67_A(0.0605);3d68_C(0.0582);3d67_C(0.0616) Cluster-exclusive K:1 0.0515 1 1 lusc:1 ENST00000181383 4 3d LDB2 N332 332 543 2jtn_A(0.0516) Cluster-exclusive K:2 0.0516 2 2 lusc:1|luad:1 ENST00000304523 5 3d LDB2 G333 333 543 2jtn_A(0.0516) Cluster-exclusive S:1 0.0516 1 1 lihc:1 ENST00000304523 5 3d LDB2 D336 336 543 2jtn_A(0.0516) Cluster-exclusive N:1 0.0516 1 1 skcm:1 ENST00000304523 5 3d LDB2 E337 337 543 2jtn_A(0.0516) Cluster-exclusive K:2 0.0516 2 2 skcm:1|cscc:1 ENST00000304523 5 3d FKBP14 R40 40 545 4msp_B(0.0523);4msp_A(0.0539) Cluster-exclusive C:1|H:1 0.0523 2 2 blca:1|hnsc:1 ENST00000222803 5 3d FKBP14 L47 47 545 4msp_B(0.0523);4msp_A(0.0539) Cluster-exclusive F:1 0.0523 1 1 hnsc:1 ENST00000222803 5 3d FKBP14 I134 134 545 4msp_B(0.0523);4msp_A(0.0539) Cluster-exclusive S:1 0.0523 1 1 stad:1 ENST00000222803 5 3d FKBP14 R135 135 545 4msp_B(0.0523);4msp_A(0.0539) Cluster-exclusive Q:2 0.0523 2 2 coadread:1|ucec:1 ENST00000222803 5 3d MAP2K5 R20 20 546 2npt_C(0.0649);2o2v_A(0.0523);2npt_A(0.0593) Cluster-exclusive H:1 0.0523 1 1 coadread:1 ENST00000178640 5 3d MAP2K5 I21 21 546 2npt_C(0.0649);2o2v_A(0.0523);2npt_A(0.0593) Cluster-exclusive M:1 0.0523 1 1 blca:1 ENST00000178640 5 3d MAP2K5 A28 28 546 2npt_C(0.0649);2o2v_A(0.0523);2npt_A(0.0593) Cluster-exclusive T:1 0.0523 1 1 coadread:1 ENST00000178640 5 3d MAP2K5 D30 30 546 2npt_C(0.0649);2o2v_A(0.0523);2npt_A(0.0593) Cluster-exclusive G:1 0.0523 1 1 lihc:1 ENST00000178640 5 3d MAP2K5 P101 101 546 2npt_C(0.0649);2o2v_A(0.0523);2npt_A(0.0593) Cluster-exclusive S:1 0.0523 1 1 ucec:1 ENST00000178640 5 3d PTPN11 P33 33 548 4fr4_D(0.0556);4fr4_C(0.0526);4fr4_E(0.0539);4fr4_B(0.0572);4fr4_A(0.0539) Hotspot-linked S:1|L:1 0.0526 2 2 skcm:1|cscc:1 ENST00000351677 2 3d PTPN11 M82 82 548 4fr4_D(0.0556);4fr4_C(0.0526);4fr4_E(0.0539);4fr4_B(0.0572);4fr4_A(0.0539) Hotspot-linked V:1 0.0526 1 1 luad:1 ENST00000351677 2 3d CCL7 Q24 24 549 1ncv_A(0.0529) Cluster-exclusive H:1 0.0529 1 1 nbl:1 ENST00000378569 2 3d IL18R1 K134 134 550 3wo3_J(0.053);3wo3_H(0.0656);3wo3_F(0.0642);3wo3_D(0.0638);3wo4_B(0.0599);3wo3_B(0.0625) Cluster-exclusive Q:1|T:1 0.053 2 2 lihc:1|ucec:1 ENST00000233957 1 3d IL18R1 F135 135 550 3wo3_J(0.053);3wo3_H(0.0656);3wo3_F(0.0642);3wo3_D(0.0638);3wo4_B(0.0599);3wo3_B(0.0625) Cluster-exclusive I:3 0.053 3 1 coadread:3 ENST00000233957 1 3d IL18R1 F136 136 550 3wo3_J(0.053);3wo3_H(0.0656);3wo3_F(0.0642);3wo3_D(0.0638);3wo4_B(0.0599);3wo3_B(0.0625) Cluster-exclusive V:1 0.053 1 1 coadread:1 ENST00000233957 1 3d IL18R1 A175 175 550 3wo3_J(0.053);3wo3_H(0.0656);3wo3_F(0.0642);3wo3_D(0.0638);3wo4_B(0.0599);3wo3_B(0.0625) Cluster-exclusive T:1|V:1 0.053 2 2 coadread:1|cscc:1 ENST00000233957 1 3d IL18R1 E176 176 550 3wo3_J(0.053);3wo3_H(0.0656);3wo3_F(0.0642);3wo3_D(0.0638);3wo4_B(0.0599);3wo3_B(0.0625) Cluster-exclusive A:1|K:2 0.053 3 3 coadread:1|esca:1|ucec:1 ENST00000233957 1 3d GPAM Y494 494 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive C:1 0.0534 1 1 hnsc:1 ENST00000348367 4 3d GPAM G541 541 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive R:1|E:1 0.0534 2 2 coadread:1|skcm:1 ENST00000348367 4 3d GPAM D553 553 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive Y:1|N:1 0.0534 2 2 acc:1|prad:1 ENST00000348367 4 3d GPAM P602 602 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive S:1 0.0534 1 1 skcm:1 ENST00000348367 4 3d GPAM S604 604 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive T:1 0.0534 1 1 luad:1 ENST00000348367 4 3d GPAM P669 669 554 2j4e_G(0.0577);2j4e_H(0.0639);2car_B(0.0534);2car_A(0.0561);2j4e_A(0.058);2i5d_A(0.0655);2j4e_B(0.0623);2j4e_E(0.0583);2j4e_D(0.0619) Cluster-exclusive S:1 0.0534 1 1 skcm:1 ENST00000348367 4 3d PSAP F342 342 555 2z9a_A(0.0556);2z9a_B(0.055);1sn6_A(0.0685);2qyp_B(0.0534);2gtg_A(0.0989) Cluster-exclusive L:1 0.0534 1 1 lihc:1 ENST00000394936 3 3d PSAP T363 363 555 2z9a_A(0.0556);2z9a_B(0.055);1sn6_A(0.0685);2qyp_B(0.0534);2gtg_A(0.0989) Cluster-exclusive M:1 0.0534 1 1 paad:1 ENST00000394936 3 3d PSAP G365 365 555 2z9a_A(0.0556);2z9a_B(0.055);1sn6_A(0.0685);2qyp_B(0.0534);2gtg_A(0.0989) Cluster-exclusive S:1 0.0534 1 1 coadread:1 ENST00000394936 3 3d PARP1 S274 274 557 4oqa_A(0.0592);4oqb_A(0.0581);4opx_D(0.0635);4opx_A(0.0578);4oqb_D(0.0583);4oqa_D(0.0536) Cluster-exclusive F:1 0.0536 1 1 hnsc:1 ENST00000366794 5 3d PARP1 G275 275 557 4oqa_A(0.0592);4oqb_A(0.0581);4opx_D(0.0635);4opx_A(0.0578);4oqb_D(0.0583);4oqa_D(0.0536) Cluster-exclusive V:1 0.0536 1 1 kirp:1 ENST00000366794 5 3d PARP1 S277 277 557 4oqa_A(0.0592);4oqb_A(0.0581);4opx_D(0.0635);4opx_A(0.0578);4oqb_D(0.0583);4oqa_D(0.0536) Cluster-exclusive W:1 0.0536 1 1 mmyl:1 ENST00000366794 5 3d PARP1 A278 278 557 4oqa_A(0.0592);4oqb_A(0.0581);4opx_D(0.0635);4opx_A(0.0578);4oqb_D(0.0583);4oqa_D(0.0536) Cluster-exclusive V:1 0.0536 1 1 ucec:1 ENST00000366794 5 3d PARP1 I279 279 557 4oqa_A(0.0592);4oqb_A(0.0581);4opx_D(0.0635);4opx_A(0.0578);4oqb_D(0.0583);4oqa_D(0.0536) Cluster-exclusive L:1 0.0536 1 1 cscc:1 ENST00000366794 5 3d SLIT2 D503 503 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive Y:2|N:1 0.0538 3 3 brca:1|hnsc:1|luad:1 ENST00000504154 1 3d SLIT2 L504 504 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive Q:1 0.0538 1 1 stad:1 ENST00000504154 1 3d SLIT2 R539 539 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive H:1 0.0538 1 1 kich:1 ENST00000504154 1 3d HES1 R35 35 560 2mh3_B(0.0538) Cluster-exclusive K:1 0.0538 1 1 cesc:1 ENST00000232424 3 3d HES1 E43 43 560 2mh3_B(0.0538) Cluster-exclusive V:1 0.0538 1 1 lihc:1 ENST00000232424 3 3d HES1 K44 44 560 2mh3_B(0.0538) Cluster-exclusive N:1 0.0538 1 1 gbm:1 ENST00000232424 3 3d HES1 R46 46 560 2mh3_B(0.0538) Cluster-exclusive Q:2 0.0538 2 2 brca:1|blca:1 ENST00000232424 3 3d STARD5 L50 50 563 2r55_A(0.054) Cluster-exclusive M:1 0.054 1 1 gbm:1 ENST00000302824 6 3d STARD5 G53 53 563 2r55_A(0.054) Cluster-exclusive R:1 0.054 1 1 skcm:1 ENST00000302824 6 3d STARD5 F175 175 563 2r55_A(0.054) Cluster-exclusive L:1 0.054 1 1 cesc:1 ENST00000302824 6 3d STARD5 F176 176 563 2r55_A(0.054) Cluster-exclusive L:1 0.054 1 1 blca:1 ENST00000302824 6 3d STARD5 H177 177 563 2r55_A(0.054) Cluster-exclusive R:1 0.054 1 1 blca:1 ENST00000302824 6 3d STARD5 G48 48 564 2r55_B(0.058);2r55_A(0.054) Cluster-exclusive V:1 0.054 1 1 lihc:1 ENST00000302824 6 3d CCND1 S41 41 565 2w9z_A(0.0542);2w96_A(0.062);2w99_A(0.0626);2w9f_A(0.0657) Hotspot-linked T:1|L:1 0.0542 2 2 blca:1|mcl:1 ENST00000227507 2 3d CCND1 V42 42 565 2w9z_A(0.0542);2w96_A(0.062);2w99_A(0.0626);2w9f_A(0.0657) Hotspot-linked E:1 0.0542 1 1 mcl:1 ENST00000227507 2 3d CCND1 Y44 44 565 2w9z_A(0.0542);2w96_A(0.062);2w99_A(0.0626);2w9f_A(0.0657) Hotspot S:1|C:1|D:2|F:1|H:1 0.0542 6 2 mmyl:1|mcl:5 ENST00000227507 2 3d CCND1 K46 46 565 2w9z_A(0.0542);2w96_A(0.062);2w99_A(0.0626);2w9f_A(0.0657) Hotspot-linked E:1|N:1 0.0542 2 2 mmyl:1|mcl:1 ENST00000227507 2 3d CCND1 C47 47 565 2w9z_A(0.0542);2w96_A(0.062);2w99_A(0.0626);2w9f_A(0.0657) Hotspot-linked S:3 0.0542 3 2 mmyl:1|mcl:2 ENST00000227507 2 3d NEDD8 V23 23 566 2ko3_A(0.0542) Cluster-exclusive M:1 0.0542 1 1 luad:1 ENST00000250495 5 3d NEDD8 R25 25 566 2ko3_A(0.0542) Cluster-exclusive Q:2 0.0542 2 2 coadread:1|luad:1 ENST00000250495 5 3d NEDD8 I26 26 566 2ko3_A(0.0542) Cluster-exclusive M:1 0.0542 1 1 brca:1 ENST00000250495 5 3d NEDD8 R29 29 566 2ko3_A(0.0542) Cluster-exclusive C:2 0.0542 2 1 mbl:2 ENST00000250495 5 3d NEDD8 T55 55 566 2ko3_A(0.0542) Cluster-exclusive R:1 0.0542 1 1 hnsc:1 ENST00000250495 5 3d HDAC1 R34 34 567 3max_C(0.0598);3max_B(0.0543);4ly1_C(0.0639);3max_A(0.059);4ly1_B(0.0596);4ly1_A(0.0557);4lxz_C(0.0542);4lxz_A(0.0618);4lxz_B(0.0592);4bkx_B(0.0874) Cluster-exclusive Q:1 0.0542 1 1 ucec:1 ENST00000373548 3 3d HDAC1 L266 266 567 3max_C(0.0598);3max_B(0.0543);4ly1_C(0.0639);3max_A(0.059);4ly1_B(0.0596);4ly1_A(0.0557);4lxz_C(0.0542);4lxz_A(0.0618);4lxz_B(0.0592);4bkx_B(0.0874) Cluster-exclusive I:1 0.0542 1 1 lihc:1 ENST00000373548 3 3d HDAC1 R306 306 567 3max_C(0.0598);3max_B(0.0543);4ly1_C(0.0639);3max_A(0.059);4ly1_B(0.0596);4ly1_A(0.0557);4lxz_C(0.0542);4lxz_A(0.0618);4lxz_B(0.0592);4bkx_B(0.0874) Cluster-exclusive L:1 0.0542 1 1 lusc:1 ENST00000373548 3 3d HDAC1 V308 308 567 3max_C(0.0598);3max_B(0.0543);4ly1_C(0.0639);3max_A(0.059);4ly1_B(0.0596);4ly1_A(0.0557);4lxz_C(0.0542);4lxz_A(0.0618);4lxz_B(0.0592);4bkx_B(0.0874) Cluster-exclusive I:1 0.0542 1 1 stad:1 ENST00000373548 3 3d HDAC1 C311 311 567 3max_C(0.0598);3max_B(0.0543);4ly1_C(0.0639);3max_A(0.059);4ly1_B(0.0596);4ly1_A(0.0557);4lxz_C(0.0542);4lxz_A(0.0618);4lxz_B(0.0592);4bkx_B(0.0874) Cluster-exclusive Y:1 0.0542 1 1 ucec:1 ENST00000373548 3 3d DLG4 G81 81 568 1rgr_A(0.0544);1iu2_A(0.0996);1iu0_A(0.086) Cluster-exclusive C:1|V:1 0.0544 2 1 luad:2 ENST00000399506 2 3d DLG4 G89 89 568 1rgr_A(0.0544);1iu2_A(0.0996);1iu0_A(0.086) Cluster-exclusive S:2|V:1 0.0544 3 3 mmyl:1|coadread:1|luad:1 ENST00000399506 2 3d DLG4 D91 91 568 1rgr_A(0.0544);1iu2_A(0.0996);1iu0_A(0.086) Cluster-exclusive N:1 0.0544 1 1 ucec:1 ENST00000399506 2 3d DLG4 P92 92 568 1rgr_A(0.0544);1iu2_A(0.0996);1iu0_A(0.086) Cluster-exclusive S:1 0.0544 1 1 skcm:1 ENST00000399506 2 3d DLG4 S93 93 568 1rgr_A(0.0544);1iu2_A(0.0996);1iu0_A(0.086) Cluster-exclusive F:1 0.0544 1 1 skcm:1 ENST00000399506 2 3d C2ORF16 D1105 1105 569 1rh2_A(0.0544) Cluster-exclusive N:1 0.0544 1 1 skcm:1 ENST00000408964 2 3d C2ORF16 V1106 1106 569 1rh2_A(0.0544) Cluster-exclusive A:1 0.0544 1 1 ucec:1 ENST00000408964 2 3d C2ORF16 P1109 1109 569 1rh2_A(0.0544) Cluster-exclusive H:1 0.0544 1 1 ucec:1 ENST00000408964 2 3d C2ORF16 P1104 1104 570 1rh2_A(0.0544) Cluster-exclusive T:1 0.0544 1 1 luad:1 ENST00000408964 2 3d C2ORF16 Q1053 1053 571 1rh2_A(0.0544) Cluster-exclusive H:1 0.0544 1 1 lusc:1 ENST00000408964 2 3d C2ORF16 S1054 1054 571 1rh2_A(0.0544) Cluster-exclusive R:1 0.0544 1 1 lusc:1 ENST00000408964 2 3d C2ORF16 D1055 1055 571 1rh2_A(0.0544) Cluster-exclusive N:1 0.0544 1 1 skcm:1 ENST00000408964 2 3d H4C16 A34 34 572 1hio_D(0.0544) Cluster-exclusive V:1 0.0544 1 1 hnsc:1 ENST00000539745 1 3d H4C16 R37 37 572 1hio_D(0.0544) Cluster-exclusive C:1 0.0544 1 1 ov:1 ENST00000539745 1 3d H4C16 R40 40 572 1hio_D(0.0544) Cluster-exclusive Q:1 0.0544 1 1 ov:1 ENST00000539745 1 3d RXRA R426 426 573 3a9e_A(0.0545);3r2a_C(0.0591) Hotspot-linked H:1 0.0545 1 1 hnsc:1 ENST00000481739 1 3d RXRA S427 427 573 3a9e_A(0.0545);3r2a_C(0.0591) Hotspot F:11|Y:3 0.0545 14 3 paad:1|blca:12|lihc:1 ENST00000481739 1 3d RXRA G429 429 573 3a9e_A(0.0545);3r2a_C(0.0591) Hotspot-linked V:1 0.0545 1 1 luad:1 ENST00000481739 1 3d RXRA L430 430 573 3a9e_A(0.0545);3r2a_C(0.0591) Hotspot-linked H:1 0.0545 1 1 lihc:1 ENST00000481739 1 3d ZNF98 P489 489 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive H:1 0.0547 1 1 lusc:1 ENST00000357774 5 3d TUBB2A E69 69 579 3du7_B(0.075);1sa1_D(0.0721);3j1t_C(0.0547);3j1u_C(0.0581) Cluster-exclusive K:1 0.0547 1 1 lusc:1 ENST00000333628 3 3d TUBB2A T72 72 579 3du7_B(0.075);1sa1_D(0.0721);3j1t_C(0.0547);3j1u_C(0.0581) Cluster-exclusive I:1 0.0547 1 1 ucec:1 ENST00000333628 3 3d TUBB2A Q94 94 579 3du7_B(0.075);1sa1_D(0.0721);3j1t_C(0.0547);3j1u_C(0.0581) Cluster-exclusive H:1 0.0547 1 1 luad:1 ENST00000333628 3 3d TUBB2A S95 95 579 3du7_B(0.075);1sa1_D(0.0721);3j1t_C(0.0547);3j1u_C(0.0581) Cluster-exclusive N:2 0.0547 2 2 skcm:1|cscc:1 ENST00000333628 3 3d CFH P695 695 580 2kms_A(0.0549) Cluster-exclusive H:1 0.0549 1 1 prad:1 ENST00000367429 4 3d CFH E696 696 580 2kms_A(0.0549) Cluster-exclusive D:1 0.0549 1 1 coadread:1 ENST00000367429 4 3d CFH W701 701 580 2kms_A(0.0549) Cluster-exclusive L:1 0.0549 1 1 skcm:1 ENST00000367429 4 3d CFH A702 702 580 2kms_A(0.0549) Cluster-exclusive T:1|V:1 0.0549 2 2 kirc:1|cscc:1 ENST00000367429 4 3d CFH S705 705 580 2kms_A(0.0549) Cluster-exclusive F:1 0.0549 1 1 brca:1 ENST00000367429 4 3d CFH E716 716 580 2kms_A(0.0549) Cluster-exclusive K:1 0.0549 1 1 skcm:1 ENST00000367429 4 3d CFH F717 717 580 2kms_A(0.0549) Cluster-exclusive I:1 0.0549 1 1 lusc:1 ENST00000367429 4 3d CFH R729 729 580 2kms_A(0.0549) Cluster-exclusive I:1 0.0549 1 1 luad:1 ENST00000367429 4 3d CFH S730 730 580 2kms_A(0.0549) Cluster-exclusive L:1 0.0549 1 1 skcm:1 ENST00000367429 4 3d CFH P742 742 580 2kms_A(0.0549) Cluster-exclusive S:1 0.0549 1 1 skcm:1 ENST00000367429 4 3d GUCA1A R93 93 583 2r2i_A(0.0554) Cluster-exclusive H:2 0.0554 2 1 stad:2 ENST00000053469 4 3d GUCA1A F96 96 583 2r2i_A(0.0554) Cluster-exclusive L:1 0.0554 1 1 luad:1 ENST00000053469 4 3d GUCA1A L98 98 583 2r2i_A(0.0554) Cluster-exclusive F:1 0.0554 1 1 mds:1 ENST00000053469 4 3d GUCA1A D100 100 583 2r2i_A(0.0554) Cluster-exclusive G:1 0.0554 1 1 stad:1 ENST00000053469 4 3d GUCA1A G105 105 583 2r2i_A(0.0554) Cluster-exclusive S:1|D:1 0.0554 2 2 cscc:1|luad:1 ENST00000053469 4 3d BRAF W604 604 584 4wo5_A(0.0555) Hotspot-linked L:1 0.0555 1 1 luad:1 ENST00000288602 6 3d HGFAC T476 476 585 3k2u_A(0.0558) Cluster-exclusive P:1 0.0558 1 1 ucs:1 ENST00000382774 3 3d HGFAC E480 480 585 3k2u_A(0.0558) Cluster-exclusive K:2 0.0558 2 2 stad:1|skcm:1 ENST00000382774 3 3d HGFAC R502 502 585 3k2u_A(0.0558) Cluster-exclusive Q:1 0.0558 1 1 cscc:1 ENST00000382774 3 3d RORC R367 367 586 4s14_A(0.0562) Cluster-exclusive W:1 0.0562 1 1 stad:1 ENST00000318247 6 3d PBRM1 K702 702 588 4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);4q0n_G(0.0652);4q0n_F(0.0673);3g0j_A(0.0565);4q0n_E(0.06);3mb4_A(0.0987);3mb4_B(0.0883);4q0n_D(0.0565);4q0n_H(0.0677) Cluster-exclusive T:1 0.0565 1 1 skcm:1 ENST00000394830 3 3d PBRM1 M731 731 588 4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);4q0n_G(0.0652);4q0n_F(0.0673);3g0j_A(0.0565);4q0n_E(0.06);3mb4_A(0.0987);3mb4_B(0.0883);4q0n_D(0.0565);4q0n_H(0.0677) Cluster-exclusive K:1 0.0565 1 1 luad:1 ENST00000394830 3 3d PBRM1 N734 734 588 4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);4q0n_G(0.0652);4q0n_F(0.0673);3g0j_A(0.0565);4q0n_E(0.06);3mb4_A(0.0987);3mb4_B(0.0883);4q0n_D(0.0565);4q0n_H(0.0677) Cluster-exclusive D:1 0.0565 1 1 skcm:1 ENST00000394830 3 3d PBRM1 A735 735 588 4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);4q0n_G(0.0652);4q0n_F(0.0673);3g0j_A(0.0565);4q0n_E(0.06);3mb4_A(0.0987);3mb4_B(0.0883);4q0n_D(0.0565);4q0n_H(0.0677) Cluster-exclusive V:1 0.0565 1 1 skcm:1 ENST00000394830 3 3d PBRM1 N739 739 588 4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);4q0n_G(0.0652);4q0n_F(0.0673);3g0j_A(0.0565);4q0n_E(0.06);3mb4_A(0.0987);3mb4_B(0.0883);4q0n_D(0.0565);4q0n_H(0.0677) Cluster-exclusive S:1 0.0565 1 1 luad:1 ENST00000394830 3 3d PBRM1 A749 749 589 4q0n_G(0.0652);4q0n_F(0.0673);4q0n_E(0.06);4q0n_D(0.0565);4q0n_H(0.0677);4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);3mb4_A(0.0987);3g0j_A(0.0565);3g0j_B(0.0687);3mb4_B(0.0883) Cluster-exclusive S:1 0.0565 1 1 acc:1 ENST00000394830 3 3d RAB33B T117 117 590 1z06_A(0.0566) Cluster-exclusive A:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d RAB33B K149 149 590 1z06_A(0.0566) Cluster-exclusive N:1 0.0566 1 1 skcm:1 ENST00000305626 5 3d RAB33B L152 152 590 1z06_A(0.0566) Cluster-exclusive F:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d RAB33B S154 154 590 1z06_A(0.0566) Cluster-exclusive N:1 0.0566 1 1 esca:1 ENST00000305626 5 3d RAB33B I156 156 590 1z06_A(0.0566) Cluster-exclusive M:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d RAB33B D115 115 591 1z06_A(0.0566) Cluster-exclusive N:1 0.0566 1 1 cesc:1 ENST00000305626 5 3d EGR3 C335 335 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive S:1 0.0569 1 1 acc:1 ENST00000317216 2 3d EGR3 R340 340 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive S:2 0.0569 2 2 kich:1|lihc:1 ENST00000317216 2 3d EGR3 D346 346 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive E:1|H:1 0.0569 2 2 blca:1|luad:1 ENST00000317216 2 3d EGR3 K349 349 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive E:1 0.0569 1 1 lihc:1 ENST00000317216 2 3d EGR3 H351 351 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive R:1 0.0569 1 1 lihc:1 ENST00000317216 2 3d EGR3 K353 353 593 1a1g_A(0.0641);1p47_B(0.0569);1a1f_A(0.0684) Cluster-exclusive E:1 0.0569 1 1 coadread:1 ENST00000317216 2 3d H3C6 A2 2 595 4hsu_C(0.057);4gu0_E(0.0604) Cluster-exclusive V:1 0.057 1 1 ucec:1 ENST00000360408 1 3d H3C6 T4 4 595 4hsu_C(0.057);4gu0_E(0.0604) Cluster-exclusive S:1 0.057 1 1 luad:1 ENST00000360408 1 3d H3C6 Q6 6 595 4hsu_C(0.057);4gu0_E(0.0604) Cluster-exclusive H:1 0.057 1 1 acc:1 ENST00000360408 1 3d H3C6 T7 7 595 4hsu_C(0.057);4gu0_E(0.0604) Cluster-exclusive A:1 0.057 1 1 stad:1 ENST00000360408 1 3d CDK2 Q113 113 597 3s0o_A(0.0572);1pf8_A(0.066) Cluster-exclusive H:1 0.0572 1 1 coadread:1 ENST00000266970 4 3d CDK2 C118 118 597 3s0o_A(0.0572);1pf8_A(0.066) Cluster-exclusive F:1 0.0572 1 1 luad:1 ENST00000266970 4 3d CDK2 H121 121 597 3s0o_A(0.0572);1pf8_A(0.066) Cluster-exclusive Y:1 0.0572 1 1 cscc:1 ENST00000266970 4 3d CDK2 R122 122 597 3s0o_A(0.0572);1pf8_A(0.066) Cluster-exclusive G:1|L:1 0.0572 2 2 coadread:1|luad:1 ENST00000266970 4 3d CDK2 L124 124 597 3s0o_A(0.0572);1pf8_A(0.066) Cluster-exclusive P:1 0.0572 1 1 stad:1 ENST00000266970 4 3d MKI67 P1372 1372 598 2vig_D(0.0997);2vig_B(0.0573);2vig_H(0.0659);2vig_F(0.0972);1jqi_A(0.0822) Cluster-exclusive S:1 0.0573 1 1 stad:1 ENST00000368654 3 3d MKI67 E1374 1374 598 2vig_D(0.0997);2vig_B(0.0573);2vig_H(0.0659);2vig_F(0.0972);1jqi_A(0.0822) Cluster-exclusive K:4 0.0573 4 2 coadread:2|ucec:2 ENST00000368654 3 3d MKI67 S1376 1376 598 2vig_D(0.0997);2vig_B(0.0573);2vig_H(0.0659);2vig_F(0.0972);1jqi_A(0.0822) Cluster-exclusive Y:1 0.0573 1 1 coadread:1 ENST00000368654 3 3d MKI67 E1379 1379 598 2vig_D(0.0997);2vig_B(0.0573);2vig_H(0.0659);2vig_F(0.0972);1jqi_A(0.0822) Cluster-exclusive D:1|K:1 0.0573 2 2 coadread:1|skcm:1 ENST00000368654 3 3d CAMK1 G214 214 601 4fgb_A(0.0576) Cluster-exclusive S:2 0.0576 2 2 ucec:1|kirp:1 ENST00000256460 3 3d COLEC11 A190 190 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive S:1 0.0579 1 1 luad:1 ENST00000349077 4 3d COLEC11 A191 191 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive T:4 0.0579 4 4 brca:1|paad:1|ucec:1|kirc:1 ENST00000349077 4 3d COLEC11 L193 193 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive Q:1 0.0579 1 1 stad:1 ENST00000349077 4 3d COLEC11 A194 194 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive V:1 0.0579 1 1 hnsc:1 ENST00000349077 4 3d COLEC11 Q195 195 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive K:1 0.0579 1 1 all:1 ENST00000349077 4 3d COLEC11 A199 199 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive T:1 0.0579 1 1 coadread:1 ENST00000349077 4 3d COLEC11 R200 200 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive C:1 0.0579 1 1 skcm:1 ENST00000349077 4 3d COLEC11 V201 201 602 4yli_D(0.0782);4yli_B(0.092);4ymd_A(0.0762);4ymd_D(0.0817);4ymd_E(0.0579);4yli_E(0.0585) Cluster-exclusive A:1 0.0579 1 1 lihc:1 ENST00000349077 4 3d PCDHA4 A618 618 604 2bo9_B(0.0581) Cluster-exclusive T:1 0.0581 1 1 coadread:1 ENST00000530339 1 3d PCDHA4 R619 619 604 2bo9_B(0.0581) Cluster-exclusive H:4 0.0581 4 3 coadread:1|hnsc:1|ucec:2 ENST00000530339 1 3d PCDHA4 P621 621 604 2bo9_B(0.0581) Cluster-exclusive S:2|L:3 0.0581 5 2 skcm:4|lusc:1 ENST00000530339 1 3d PCDHA4 A642 642 604 2bo9_B(0.0581) Cluster-exclusive T:1 0.0581 1 1 ucec:1 ENST00000530339 1 3d PCDHA4 P643 643 604 2bo9_B(0.0581) Cluster-exclusive A:1|L:1 0.0581 2 1 brca:2 ENST00000530339 1 3d PCDHA4 R644 644 604 2bo9_B(0.0581) Cluster-exclusive H:3 0.0581 3 2 stad:1|ucec:2 ENST00000530339 1 3d PCDHA4 H645 645 604 2bo9_B(0.0581) Cluster-exclusive R:1 0.0581 1 1 esca:1 ENST00000530339 1 3d PCDHA4 R646 646 604 2bo9_B(0.0581) Cluster-exclusive H:1 0.0581 1 1 coadread:1 ENST00000530339 1 3d PCDHA4 D653 653 604 2bo9_B(0.0581) Cluster-exclusive N:1 0.0581 1 1 cscc:1 ENST00000530339 1 3d PCDHA4 E656 656 604 2bo9_B(0.0581) Cluster-exclusive K:1 0.0581 1 1 mcl:1 ENST00000530339 1 3d AMT R331 331 605 1wsr_A(0.0581);1wsr_B(0.0663);1wsv_A(0.0618);1wsv_B(0.0634) Cluster-exclusive Q:2 0.0581 2 1 stad:2 ENST00000273588 3 3d AMT S349 349 605 1wsr_A(0.0581);1wsr_B(0.0663);1wsv_A(0.0618);1wsv_B(0.0634) Cluster-exclusive N:1 0.0581 1 1 blca:1 ENST00000273588 3 3d AMT C351 351 605 1wsr_A(0.0581);1wsr_B(0.0663);1wsv_A(0.0618);1wsv_B(0.0634) Cluster-exclusive F:1 0.0581 1 1 hnsc:1 ENST00000273588 3 3d AMT S353 353 605 1wsr_A(0.0581);1wsr_B(0.0663);1wsv_A(0.0618);1wsv_B(0.0634) Cluster-exclusive F:1 0.0581 1 1 blca:1 ENST00000273588 3 3d AMT K358 358 605 1wsr_A(0.0581);1wsr_B(0.0663);1wsv_A(0.0618);1wsv_B(0.0634) Cluster-exclusive R:1 0.0581 1 1 lihc:1 ENST00000273588 3 3d PRUNE2 E914 914 606 1xv9_B(0.0585);1xvp_B(0.0681) Cluster-exclusive K:2 0.0585 2 1 skcm:2 ENST00000376718 3 3d PRUNE2 D917 917 606 1xv9_B(0.0585);1xvp_B(0.0681) Cluster-exclusive E:1 0.0585 1 1 brca:1 ENST00000376718 3 3d PRUNE2 S918 918 606 1xv9_B(0.0585);1xvp_B(0.0681) Cluster-exclusive F:1 0.0585 1 1 skcm:1 ENST00000376718 3 3d PRUNE2 L921 921 606 1xv9_B(0.0585);1xvp_B(0.0681) Cluster-exclusive F:1 0.0585 1 1 lusc:1 ENST00000376718 3 3d PRUNE2 F922 922 606 1xv9_B(0.0585);1xvp_B(0.0681) Cluster-exclusive S:1 0.0585 1 1 lihc:1 ENST00000376718 3 3d STK24 A119 119 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive T:1 0.0586 1 1 coadread:1 ENST00000376547 3 3d STK24 A134 134 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive T:4 0.0586 4 3 ucs:1|ucec:2|luad:1 ENST00000376547 3 3d STK24 I136 136 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive M:1 0.0586 1 1 ucec:1 ENST00000376547 3 3d STK24 E139 139 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive K:1 0.0586 1 1 ucec:1 ENST00000376547 3 3d STK24 I140 140 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive M:1 0.0586 1 1 gbm:1 ENST00000376547 3 3d STK24 V170 170 607 3ckw_A(0.0586);3ckx_A(0.0807);3a7f_A(0.0728);3a7g_A(0.0707);3a7g_B(0.0726);3a7h_A(0.0669);3a7i_A(0.076);3a7h_B(0.0718);3zhp_D(0.0617);3a7j_A(0.0698);3zhp_C(0.0687) Cluster-exclusive M:1 0.0586 1 1 cscc:1 ENST00000376547 3 3d KLHL3 L153 153 608 4i1e_A(0.0606);4i8m_A(0.0586);4i2s_A(0.0626);4i7i_A(0.0618);4i0y_A(0.0595);4i3n_A(0.0621) Cluster-exclusive M:1 0.0586 1 1 coadread:1 ENST00000309755 4 3d KLHL3 G154 154 608 4i1e_A(0.0606);4i8m_A(0.0586);4i2s_A(0.0626);4i7i_A(0.0618);4i0y_A(0.0595);4i3n_A(0.0621) Cluster-exclusive V:1 0.0586 1 1 luad:1 ENST00000309755 4 3d KLHL3 R156 156 608 4i1e_A(0.0606);4i8m_A(0.0586);4i2s_A(0.0626);4i7i_A(0.0618);4i0y_A(0.0595);4i3n_A(0.0621) Cluster-exclusive C:1 0.0586 1 1 skcm:1 ENST00000309755 4 3d KLHL3 S208 208 608 4i1e_A(0.0606);4i8m_A(0.0586);4i2s_A(0.0626);4i7i_A(0.0618);4i0y_A(0.0595);4i3n_A(0.0621) Cluster-exclusive Y:1 0.0586 1 1 coadread:1 ENST00000309755 4 3d DOCK6 V1754 1754 610 3vhl_A(0.0587) Cluster-exclusive M:1 0.0587 1 1 coadread:1 ENST00000294618 7 3d DOCK6 F1756 1756 610 3vhl_A(0.0587) Cluster-exclusive L:1 0.0587 1 1 stad:1 ENST00000294618 7 3d DOCK6 G1758 1758 610 3vhl_A(0.0587) Cluster-exclusive C:1 0.0587 1 1 kirp:1 ENST00000294618 7 3d DOCK6 E1766 1766 610 3vhl_A(0.0587) Cluster-exclusive K:1 0.0587 1 1 blca:1 ENST00000294618 7 3d ATP1A3 E754 754 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive K:1 0.0588 1 1 cesc:1 ENST00000302102 5 3d PTEN I67 67 614 1d5r_A(0.059) Cluster-exclusive T:1 0.059 1 1 ucec:1 ENST00000371953 3 3d PTEN Y68 68 614 1d5r_A(0.059) Cluster-exclusive C:1|H:1|N:1 0.059 3 3 coadread:1|ucec:1|lgg:1 ENST00000371953 3 3d NEIL1 D154 154 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive H:1 0.0593 1 1 brca:1 ENST00000355059 4 3d NEIL1 F157 157 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive S:1 0.0593 1 1 luad:1 ENST00000355059 4 3d NEIL1 D158 158 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive E:1 0.0593 1 1 cscc:1 ENST00000355059 4 3d NEIL1 R159 159 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive Q:1|W:1 0.0593 2 1 coadread:2 ENST00000355059 4 3d NEIL1 F170 170 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive L:1 0.0593 1 1 stad:1 ENST00000355059 4 3d NEIL1 R195 195 617 1tdh_A(0.0593);4nrv_A(0.0749) Cluster-exclusive C:1 0.0593 1 1 lusc:1 ENST00000355059 4 3d SERPINB3 E198 198 618 2zv6_B(0.0595) Cluster-exclusive K:2 0.0595 2 1 skcm:2 ENST00000283752 5 3d SERPINB3 F200 200 618 2zv6_B(0.0595) Cluster-exclusive S:1|L:1 0.0595 2 2 brca:1|skcm:1 ENST00000283752 5 3d SERPINB3 S209 209 618 2zv6_B(0.0595) Cluster-exclusive Y:1 0.0595 1 1 luad:1 ENST00000283752 5 3d SERPINB3 M212 212 618 2zv6_B(0.0595) Cluster-exclusive I:1 0.0595 1 1 skcm:1 ENST00000283752 5 3d SERPINB3 C365 365 618 2zv6_B(0.0595) Cluster-exclusive Y:1 0.0595 1 1 skcm:1 ENST00000283752 5 3d SERPINB3 H367 367 618 2zv6_B(0.0595) Cluster-exclusive Q:1|D:1 0.0595 2 2 brca:1|luad:1 ENST00000283752 5 3d SERPINB3 P368 368 618 2zv6_B(0.0595) Cluster-exclusive A:1 0.0595 1 1 lihc:1 ENST00000283752 5 3d SERPINB3 S389 389 618 2zv6_B(0.0595) Cluster-exclusive Y:1 0.0595 1 1 luad:1 ENST00000283752 5 3d SERPINB3 P390 390 618 2zv6_B(0.0595) Cluster-exclusive S:1|K:1 0.0595 2 1 skcm:2 ENST00000283752 5 3d PTPRD R1674 1674 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive C:1 0.0595 1 1 cesc:1 ENST00000356435 5 3d PTPRD L1675 1675 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive I:1 0.0595 1 1 luad:1 ENST00000356435 5 3d PTPRD A1716 1716 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive S:1|T:1 0.0595 2 2 paad:1|luad:1 ENST00000356435 5 3d PTPRD Q1718 1718 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive H:1 0.0595 1 1 luad:1 ENST00000356435 5 3d PTPRD G1719 1719 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive W:1 0.0595 1 1 coadread:1 ENST00000356435 5 3d PTPRD P1720 1720 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive S:1 0.0595 1 1 skcm:1 ENST00000356435 5 3d PTPRD T1724 1724 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive I:1 0.0595 1 1 skcm:1 ENST00000356435 5 3d PTPRD H1843 1843 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive Y:1 0.0595 1 1 skcm:1 ENST00000356435 5 3d PTPRD S1845 1845 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive C:1 0.0595 1 1 lusm:1 ENST00000356435 5 3d PTPRD A1846 1846 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive E:1 0.0595 1 1 luad:1 ENST00000356435 5 3d PTPRD G1847 1847 619 4bpc_A(0.0993);3sr9_A(0.0595) Cluster-exclusive V:1 0.0595 1 1 luad:1 ENST00000356435 5 3d RECQL P284 284 620 4u7d_C(0.0598) Cluster-exclusive S:1 0.0598 1 1 hnsc:1 ENST00000421138 2 3d RECQL L286 286 620 4u7d_C(0.0598) Cluster-exclusive Q:1 0.0598 1 1 brca:1 ENST00000421138 2 3d RECQL S402 402 620 4u7d_C(0.0598) Cluster-exclusive N:1 0.0598 1 1 luad:1 ENST00000421138 2 3d RECQL G403 403 620 4u7d_C(0.0598) Cluster-exclusive E:1 0.0598 1 1 ucec:1 ENST00000421138 2 3d RECQL A405 405 620 4u7d_C(0.0598) Cluster-exclusive T:1 0.0598 1 1 coadread:1 ENST00000421138 2 3d RECQL R455 455 620 4u7d_C(0.0598) Cluster-exclusive L:1 0.0598 1 1 stad:1 ENST00000421138 2 3d NME3 P117 117 621 1zs6_B(0.0606);1zs6_A(0.063);1zs6_D(0.06) Cluster-exclusive S:1 0.06 1 1 skcm:1 ENST00000219302 3 3d NME3 R122 122 621 1zs6_B(0.0606);1zs6_A(0.063);1zs6_D(0.06) Cluster-exclusive H:1 0.06 1 1 lusc:1 ENST00000219302 3 3d NME3 G123 123 621 1zs6_B(0.0606);1zs6_A(0.063);1zs6_D(0.06) Cluster-exclusive W:1 0.06 1 1 lihc:1 ENST00000219302 3 3d NME3 D124 124 621 1zs6_B(0.0606);1zs6_A(0.063);1zs6_D(0.06) Cluster-exclusive Y:1 0.06 1 1 coadread:1 ENST00000219302 3 3d GGA2 A63 63 622 1mhq_B(0.0601) Cluster-exclusive V:4 0.0601 4 2 coadread:1|ucec:3 ENST00000309859 4 3d GGA2 W65 65 622 1mhq_B(0.0601) Cluster-exclusive C:1 0.0601 1 1 skcm:1 ENST00000309859 4 3d GGA2 R105 105 622 1mhq_B(0.0601) Cluster-exclusive C:5 0.0601 5 2 skcm:4|ucec:1 ENST00000309859 4 3d GGA2 E109 109 622 1mhq_B(0.0601) Cluster-exclusive K:1 0.0601 1 1 coadread:1 ENST00000309859 4 3d POLM E165 165 623 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive G:1|K:1 0.0604 2 2 brca:1|esca:1 ENST00000242248 5 3d POLM R229 229 623 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive P:1|W:2 0.0604 3 1 ucec:3 ENST00000242248 5 3d POLM R233 233 623 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive M:1 0.0604 1 1 kirc:1 ENST00000242248 5 3d POLM Y234 234 623 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive C:1 0.0604 1 1 coadread:1 ENST00000242248 5 3d POLM Q235 235 623 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive H:1 0.0604 1 1 paad:1 ENST00000242248 5 3d POLM R230 230 624 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive H:1|L:1 0.0604 2 2 coadread:1|luad:1 ENST00000242248 5 3d KMT2C C347 347 626 2ysm_A(0.061) Cluster-exclusive W:1 0.061 1 1 luad:1 ENST00000262189 6 3d KMT2C P350 350 626 2ysm_A(0.061) Cluster-exclusive R:1 0.061 1 1 kirc:1 ENST00000262189 6 3d KMT2C G351 351 626 2ysm_A(0.061) Cluster-exclusive E:2 0.061 2 2 hnsc:1|skcm:1 ENST00000262189 6 3d KMT2C D352 352 626 2ysm_A(0.061) Cluster-exclusive Y:1 0.061 1 1 paad:1 ENST00000262189 6 3d KMT2C L353 353 626 2ysm_A(0.061) Cluster-exclusive F:1|H:1 0.061 2 2 lusc:1|luad:1 ENST00000262189 6 3d KMT2C Q356 356 626 2ysm_A(0.061) Cluster-exclusive E:1|K:2|L:1 0.061 4 2 blca:1|luad:3 ENST00000262189 6 3d KMT2C F357 357 626 2ysm_A(0.061) Cluster-exclusive L:1 0.061 1 1 luad:1 ENST00000262189 6 3d KMT2C Y366 366 626 2ysm_A(0.061) Cluster-exclusive S:1 0.061 1 1 ov:1 ENST00000262189 6 3d KMT2C H367 367 626 2ysm_A(0.061) Cluster-exclusive D:2|Y:3 0.061 5 3 brca:2|skcm:2|lihc:1 ENST00000262189 6 3d KMT2C G368 368 626 2ysm_A(0.061) Cluster-exclusive R:1|V:1 0.061 2 2 blca:1|lusc:1 ENST00000262189 6 3d KMT2C D372 372 626 2ysm_A(0.061) Cluster-exclusive N:1 0.061 1 1 skcm:1 ENST00000262189 6 3d KMT2C F358 358 627 2ysm_A(0.061) Cluster-exclusive C:1|V:1 0.061 2 2 esca:1|kirc:1 ENST00000262189 6 3d ARHGAP32 P2051 2051 629 1f5y_A(0.0614) Cluster-exclusive L:1 0.0614 1 1 luad:1 ENST00000310343 9 3d ARHGAP32 P2056 2056 629 1f5y_A(0.0614) Cluster-exclusive S:1 0.0614 1 1 cscc:1 ENST00000310343 9 3d ARHGAP32 Q2057 2057 629 1f5y_A(0.0614) Cluster-exclusive H:1 0.0614 1 1 hnsc:1 ENST00000310343 9 3d ARHGAP32 A2062 2062 629 1f5y_A(0.0614) Cluster-exclusive V:1 0.0614 1 1 hnsc:1 ENST00000310343 9 3d ARHGAP32 P2072 2072 629 1f5y_A(0.0614) Cluster-exclusive L:1 0.0614 1 1 skcm:1 ENST00000310343 9 3d BACH2 V43 43 631 3ohu_D(0.0621) Cluster-exclusive M:1 0.0621 1 1 luad:1 ENST00000257749 4 3d BACH2 L78 78 631 3ohu_D(0.0621) Cluster-exclusive V:1 0.0621 1 1 ucec:1 ENST00000257749 4 3d BACH2 E80 80 631 3ohu_D(0.0621) Cluster-exclusive K:1 0.0621 1 1 blca:1 ENST00000257749 4 3d BACH2 V82 82 631 3ohu_D(0.0621) Cluster-exclusive F:1 0.0621 1 1 brca:1 ENST00000257749 4 3d BACH2 R111 111 631 3ohu_D(0.0621) Cluster-exclusive C:1 0.0621 1 1 stad:1 ENST00000257749 4 3d BACH2 C112 112 631 3ohu_D(0.0621) Cluster-exclusive F:1 0.0621 1 1 luad:1 ENST00000257749 4 3d BACH2 F115 115 631 3ohu_D(0.0621) Cluster-exclusive L:1 0.0621 1 1 ucec:1 ENST00000257749 4 3d EGFR P753 753 632 2gs7_A(0.0778);4hjo_A(0.079);2gs7_B(0.0622) Hotspot-linked S:1|L:1 0.0622 2 2 coadread:1|skcm:1 ENST00000275493 2 3d EGFR K754 754 632 2gs7_A(0.0778);4hjo_A(0.079);2gs7_B(0.0622) Hotspot-linked E:1|I:1 0.0622 2 1 luad:2 ENST00000275493 2 3d EGFR G857 857 632 2gs7_A(0.0778);4hjo_A(0.079);2gs7_B(0.0622) Hotspot-linked V:1 0.0622 1 1 luad:1 ENST00000275493 2 3d RPS6KA3 V256 256 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive L:1 0.0622 1 1 lgg:1 ENST00000379565 3 3d RPS6KA3 L285 285 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive P:1 0.0622 1 1 luad:1 ENST00000379565 3 3d RPS6KA3 L298 298 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive F:1 0.0622 1 1 lusc:1 ENST00000379565 3 3d RPS6KA3 R300 300 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive Q:1 0.0622 1 1 stad:1 ENST00000379565 3 3d RPS6KA3 F303 303 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive L:1 0.0622 1 1 brca:1 ENST00000379565 3 3d RPS6KA3 K304 304 633 3ubd_A(0.0633);3g51_A(0.068);4nw6_A(0.083);4nus_A(0.0732);4nw5_A(0.0912);4gue_A(0.0622);4el9_A(0.0653) Cluster-exclusive E:2 0.0622 2 2 stad:1|kirp:1 ENST00000379565 3 3d PGR E723 723 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive K:2 0.0623 2 2 brca:1|hnsc:1 ENST00000325455 5 3d PGR F895 895 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive C:1 0.0623 1 1 cesc:1 ENST00000325455 5 3d PGR P906 906 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive S:2 0.0623 2 2 skcm:1|cscc:1 ENST00000325455 5 3d PGR E907 907 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive K:1 0.0623 1 1 skcm:1 ENST00000325455 5 3d PGR S910 910 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive F:1 0.0623 1 1 lusc:1 ENST00000325455 5 3d PGR E911 911 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive D:2 0.0623 2 2 stad:1|skcm:1 ENST00000325455 5 3d PGR A914 914 634 3g8o_A(0.0749);3kba_A(0.0668);1zuc_A(0.0697);1a28_A(0.0669);2w8y_B(0.072);1sqn_B(0.077);1sqn_A(0.0727);3hq5_B(0.0728);3d90_A(0.0623);3hq5_A(0.0732) Cluster-exclusive V:1 0.0623 1 1 brca:1 ENST00000325455 5 3d SORL1 S440 440 638 3wsz_A(0.0628) Cluster-exclusive L:1 0.0628 1 1 skcm:1 ENST00000260197 7 3d SORL1 L453 453 638 3wsz_A(0.0628) Cluster-exclusive F:1 0.0628 1 1 cscc:1 ENST00000260197 7 3d SORL1 Q454 454 638 3wsz_A(0.0628) Cluster-exclusive L:1 0.0628 1 1 luad:1 ENST00000260197 7 3d SORL1 S474 474 638 3wsz_A(0.0628) Cluster-exclusive F:1 0.0628 1 1 skcm:1 ENST00000260197 7 3d SORL1 H476 476 638 3wsz_A(0.0628) Cluster-exclusive Y:2 0.0628 2 2 brca:1|cscc:1 ENST00000260197 7 3d SORL1 G511 511 638 3wsz_A(0.0628) Cluster-exclusive E:2 0.0628 2 1 skcm:2 ENST00000260197 7 3d SORL1 K512 512 638 3wsz_A(0.0628) Cluster-exclusive N:1 0.0628 1 1 ucec:1 ENST00000260197 7 3d SYT7 S142 142 639 2d8k_A(0.0628) Cluster-exclusive I:1 0.0628 1 1 hnsc:1 ENST00000263846 4 3d SYT7 G144 144 639 2d8k_A(0.0628) Cluster-exclusive S:1 0.0628 1 1 ucec:1 ENST00000263846 4 3d SYT7 G151 151 639 2d8k_A(0.0628) Cluster-exclusive E:1 0.0628 1 1 skcm:1 ENST00000263846 4 3d SYT7 T153 153 639 2d8k_A(0.0628) Cluster-exclusive A:1 0.0628 1 1 paad:1 ENST00000263846 4 3d SYT7 V154 154 639 2d8k_A(0.0628) Cluster-exclusive M:1 0.0628 1 1 lgg:1 ENST00000263846 4 3d SYT7 D246 246 639 2d8k_A(0.0628) Cluster-exclusive N:1 0.0628 1 1 skcm:1 ENST00000263846 4 3d SYT7 L247 247 639 2d8k_A(0.0628) Cluster-exclusive M:1 0.0628 1 1 coadread:1 ENST00000263846 4 3d SNX17 R87 87 640 3lui_A(0.0713);3fog_A(0.0638);3lui_C(0.0696);3lui_B(0.0628) Cluster-exclusive W:1 0.0628 1 1 ucec:1 ENST00000233575 2 3d SNX17 Q88 88 640 3lui_A(0.0713);3fog_A(0.0638);3lui_C(0.0696);3lui_B(0.0628) Cluster-exclusive E:1 0.0628 1 1 ov:1 ENST00000233575 2 3d SNX17 D89 89 640 3lui_A(0.0713);3fog_A(0.0638);3lui_C(0.0696);3lui_B(0.0628) Cluster-exclusive G:1 0.0628 1 1 lihc:1 ENST00000233575 2 3d SNX17 L92 92 640 3lui_A(0.0713);3fog_A(0.0638);3lui_C(0.0696);3lui_B(0.0628) Cluster-exclusive I:1 0.0628 1 1 hnsc:1 ENST00000233575 2 3d SNX17 S94 94 640 3lui_A(0.0713);3fog_A(0.0638);3lui_C(0.0696);3lui_B(0.0628) Cluster-exclusive G:1 0.0628 1 1 lihc:1 ENST00000233575 2 3d H2BC3 F71 71 641 3an2_D(0.0629) Cluster-exclusive L:1 0.0629 1 1 lihc:1 ENST00000615966 3d H2BC3 E72 72 641 3an2_D(0.0629) Cluster-exclusive Q:1|K:1 0.0629 2 2 brca:1|luad:1 ENST00000615966 3d H2BC3 R73 73 641 3an2_D(0.0629) Cluster-exclusive C:1 0.0629 1 1 brca:1 ENST00000615966 3d H2BC3 A75 75 641 3an2_D(0.0629) Cluster-exclusive V:1 0.0629 1 1 hnsc:1 ENST00000615966 3d H2BC3 E94 94 641 3an2_D(0.0629) Cluster-exclusive D:1 0.0629 1 1 brca:1 ENST00000615966 3d H2BC3 T97 97 641 3an2_D(0.0629) Cluster-exclusive M:2 0.0629 2 2 coadread:1|lihc:1 ENST00000615966 3d PTEN Y27 27 642 1d5r_A(0.063) Cluster-exclusive D:4 0.063 4 4 brca:1|stad:1|ucec:1|lgg:1 ENST00000371953 3 3d PTEN I32 32 642 1d5r_A(0.063) Cluster-exclusive S:1 0.063 1 1 brca:1 ENST00000371953 3 3d TRIM9 P439 439 643 2db8_A(0.063) Cluster-exclusive S:2 0.063 2 2 brca:1|skcm:1 ENST00000298355 3 3d TRIM9 L467 467 643 2db8_A(0.063) Cluster-exclusive V:1 0.063 1 1 cesc:1 ENST00000298355 3 3d TRIM9 T469 469 643 2db8_A(0.063) Cluster-exclusive M:3 0.063 3 3 stad:1|ucec:1|luad:1 ENST00000298355 3 3d TRIM9 V470 470 643 2db8_A(0.063) Cluster-exclusive M:1 0.063 1 1 skcm:1 ENST00000298355 3 3d TRIM9 P471 471 643 2db8_A(0.063) Cluster-exclusive A:1 0.063 1 1 lusm:1 ENST00000298355 3 3d TRIM9 A472 472 643 2db8_A(0.063) Cluster-exclusive S:1|T:2 0.063 3 2 ucec:1|luad:2 ENST00000298355 3 3d CTSL V126 126 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive L:1|M:1 0.0632 2 2 coadread:1|lusc:1 ENST00000340342 6 3d CTSL G145 145 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive C:1 0.0632 1 1 stad:1 ENST00000340342 6 3d CTSL A146 146 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive S:1 0.0632 1 1 ov:1 ENST00000340342 6 3d CTSL Q150 150 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive H:1 0.0632 1 1 coadread:1 ENST00000340342 6 3d CTSL V242 242 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive M:2 0.0632 2 2 brca:1|stad:1 ENST00000340342 6 3d CTSL P244 244 644 1mhw_A(0.0663);1icf_C(0.0632);1icf_A(0.0677) Cluster-exclusive S:1 0.0632 1 1 kirp:1 ENST00000340342 6 3d TH S487 487 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive F:1 0.0637 1 1 skcm:1 ENST00000381178 1 3d TH V488 488 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive M:1 0.0637 1 1 ucec:1 ENST00000381178 1 3d TH I497 497 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive M:1 0.0637 1 1 cesc:1 ENST00000381178 1 3d TH D498 498 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive N:1 0.0637 1 1 coadread:1 ENST00000381178 1 3d TH R508 508 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive S:1 0.0637 1 1 luad:1 ENST00000381178 1 3d TH S509 509 645 2xsn_D(0.082);2toh_A(0.0637);2xsn_C(0.0871) Cluster-exclusive F:1 0.0637 1 1 skcm:1 ENST00000381178 1 3d ACACA G118 118 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive S:1 0.0637 1 1 luad:1 ENST00000613687 3d ACACA T138 138 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive I:1 0.0637 1 1 nbl:1 ENST00000613687 3d ACACA A140 140 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive V:1 0.0637 1 1 coadread:1 ENST00000613687 3d ACACA G150 150 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive E:1 0.0637 1 1 brca:1 ENST00000613687 3d ACACA G151 151 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive E:1 0.0637 1 1 stad:1 ENST00000613687 3d ACACA S173 173 646 3glk_A(0.0676);3gid_B(0.0717);4hq6_A(0.0655);3gid_A(0.0637) Cluster-exclusive C:1 0.0637 1 1 ucs:1 ENST00000613687 3d S100A3 E49 49 647 3nsi_A(0.0698);3nsi_B(0.0639) Hotspot-linked K:1 0.0639 1 1 brca:1 ENST00000368712 1 3d S100A3 R51 51 647 3nsi_A(0.0698);3nsi_B(0.0639) Hotspot-linked Q:1|W:1|L:1 0.0639 3 3 stad:1|ucec:1|kirp:1 ENST00000368712 1 3d S100A3 D92 92 647 3nsi_A(0.0698);3nsi_B(0.0639) Hotspot-linked N:1 0.0639 1 1 brca:1 ENST00000368712 1 3d S100A3 P97 97 647 3nsi_A(0.0698);3nsi_B(0.0639) Hotspot S:3 0.0639 3 2 stad:1|skcm:2 ENST00000368712 1 3d NCKAP1L T16 16 648 1wxu_A(0.0639) Cluster-exclusive N:1 0.0639 1 1 luad:1 ENST00000293373 6 3d NCKAP1L R21 21 648 1wxu_A(0.0639) Cluster-exclusive H:1 0.0639 1 1 brca:1 ENST00000293373 6 3d NCKAP1L G22 22 648 1wxu_A(0.0639) Cluster-exclusive V:1 0.0639 1 1 hnsc:1 ENST00000293373 6 3d NCKAP1L D38 38 648 1wxu_A(0.0639) Cluster-exclusive G:1|N:1 0.0639 2 2 coadread:1|lihc:1 ENST00000293373 6 3d NCKAP1L K40 40 648 1wxu_A(0.0639) Cluster-exclusive I:1 0.0639 1 1 stad:1 ENST00000293373 6 3d NCKAP1L E48 48 648 1wxu_A(0.0639) Cluster-exclusive K:1 0.0639 1 1 skcm:1 ENST00000293373 6 3d ACACA I131 131 650 2hjw_A(0.064) Cluster-exclusive M:1 0.064 1 1 ucec:1 ENST00000613687 3d ACACA D132 132 650 2hjw_A(0.064) Cluster-exclusive Y:1 0.064 1 1 gbm:1 ENST00000613687 3d ACACA Q134 134 650 2hjw_A(0.064) Cluster-exclusive E:1 0.064 1 1 blca:1 ENST00000613687 3d ACACA R135 135 650 2hjw_A(0.064) Cluster-exclusive Q:1 0.064 1 1 skcm:1 ENST00000613687 3d POLH T526 526 651 2lsk_B(0.0641) Cluster-exclusive A:1 0.0641 1 1 stad:1 ENST00000372236 4 3d POLH T528 528 651 2lsk_B(0.0641) Cluster-exclusive I:1 0.0641 1 1 mmyl:1 ENST00000372236 4 3d POLH P530 530 651 2lsk_B(0.0641) Cluster-exclusive L:1 0.0641 1 1 esca:1 ENST00000372236 4 3d POLH F531 531 651 2lsk_B(0.0641) Cluster-exclusive L:1 0.0641 1 1 coadread:1 ENST00000372236 4 3d POLH K533 533 651 2lsk_B(0.0641) Cluster-exclusive E:1 0.0641 1 1 lihc:1 ENST00000372236 4 3d PTPRF A1787 1787 652 3sr9_A(0.0642) Cluster-exclusive S:2|V:1 0.0642 3 3 stad:1|blca:1|cscc:1 ENST00000359947 4 3d PTPRF R1788 1788 652 3sr9_A(0.0642) Cluster-exclusive Q:2|L:1 0.0642 3 2 hnsc:1|ucec:2 ENST00000359947 4 3d PTPRF D1789 1789 652 3sr9_A(0.0642) Cluster-exclusive N:1 0.0642 1 1 skcm:1 ENST00000359947 4 3d PTPRF G1790 1790 652 3sr9_A(0.0642) Cluster-exclusive R:2|E:1 0.0642 3 2 brca:2|blca:1 ENST00000359947 4 3d PPIP5K2 L130 130 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive F:1 0.0649 1 1 hnsc:1 ENST00000358359 3 3d PPIP5K2 Y138 138 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive H:1 0.0649 1 1 skcm:1 ENST00000358359 3 3d PPIP5K2 I140 140 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive F:1 0.0649 1 1 mmyl:1 ENST00000358359 3 3d PPIP5K2 L141 141 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive P:1 0.0649 1 1 lihc:1 ENST00000358359 3 3d PPIP5K2 E144 144 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive K:1 0.0649 1 1 hnsc:1 ENST00000358359 3 3d PPIP5K2 F301 301 654 3t54_A(0.0776);4q4d_A(0.0878);4q4c_A(0.0736);3t99_A(0.0725);3t9c_A(0.0699);3t9b_A(0.0988);3t7a_A(0.0779);3t9e_A(0.08);3t9d_A(0.0686);4nzm_A(0.0703);3t9a_A(0.0812);4nzo_A(0.0719);4hn2_A(0.0649);4nzn_A(0.0764);3t9f_A(0.0757) Cluster-exclusive L:1 0.0649 1 1 brca:1 ENST00000358359 3 3d FKBP5 E45 45 655 4drp_A(0.0735);4drq_A(0.0746);4w9p_E(0.0736);3o5p_A(0.071);3o5o_A(0.0808);3o5r_A(0.0699);3o5q_A(0.0688);3o5l_A(0.0805);3o5k_B(0.0817);3o5k_A(0.0791);3o5k_D(0.0722);3o5m_B(0.0826);3o5k_C(0.0809);3o5m_A(0.0831);3o5g_A(0.0816);3o5i_B(0.0804);3o5j_A(0.0893);3o5i_A(0.0788);3o5d_A(0.0907);3o5d_B(0.0954);3o5e_A(0.0866);4drk_A(0.0761);4dri_A(0.0855);4drn_A(0.0773);4dro_A(0.0709);4drk_B(0.0783);4drm_A(0.0657);4tx0_A(0.075);4tw6_A(0.0756);4tw7_A(0.0698);4w9p_A(0.0814);4w9q_A(0.0669);4jfi_A(0.0754);4w9o_E(0.0737);4jfk_A(0.0707);4jfj_A(0.065);4jfm_A(0.0669);4w9o_A(0.0754);4jfl_A(0.0697) Cluster-exclusive K:1 0.065 1 1 skcm:1 ENST00000357266 4 3d FKBP5 P47 47 655 4drp_A(0.0735);4drq_A(0.0746);4w9p_E(0.0736);3o5p_A(0.071);3o5o_A(0.0808);3o5r_A(0.0699);3o5q_A(0.0688);3o5l_A(0.0805);3o5k_B(0.0817);3o5k_A(0.0791);3o5k_D(0.0722);3o5m_B(0.0826);3o5k_C(0.0809);3o5m_A(0.0831);3o5g_A(0.0816);3o5i_B(0.0804);3o5j_A(0.0893);3o5i_A(0.0788);3o5d_A(0.0907);3o5d_B(0.0954);3o5e_A(0.0866);4drk_A(0.0761);4dri_A(0.0855);4drn_A(0.0773);4dro_A(0.0709);4drk_B(0.0783);4drm_A(0.0657);4tx0_A(0.075);4tw6_A(0.0756);4tw7_A(0.0698);4w9p_A(0.0814);4w9q_A(0.0669);4jfi_A(0.0754);4w9o_E(0.0737);4jfk_A(0.0707);4jfj_A(0.065);4jfm_A(0.0669);4w9o_A(0.0754);4jfl_A(0.0697) Cluster-exclusive Q:1|T:1 0.065 2 2 lihc:1|ucec:1 ENST00000357266 4 3d FKBP5 A95 95 655 4drp_A(0.0735);4drq_A(0.0746);4w9p_E(0.0736);3o5p_A(0.071);3o5o_A(0.0808);3o5r_A(0.0699);3o5q_A(0.0688);3o5l_A(0.0805);3o5k_B(0.0817);3o5k_A(0.0791);3o5k_D(0.0722);3o5m_B(0.0826);3o5k_C(0.0809);3o5m_A(0.0831);3o5g_A(0.0816);3o5i_B(0.0804);3o5j_A(0.0893);3o5i_A(0.0788);3o5d_A(0.0907);3o5d_B(0.0954);3o5e_A(0.0866);4drk_A(0.0761);4dri_A(0.0855);4drn_A(0.0773);4dro_A(0.0709);4drk_B(0.0783);4drm_A(0.0657);4tx0_A(0.075);4tw6_A(0.0756);4tw7_A(0.0698);4w9p_A(0.0814);4w9q_A(0.0669);4jfi_A(0.0754);4w9o_E(0.0737);4jfk_A(0.0707);4jfj_A(0.065);4jfm_A(0.0669);4w9o_A(0.0754);4jfl_A(0.0697) Cluster-exclusive V:1 0.065 1 1 prad:1 ENST00000357266 4 3d FKBP5 M97 97 655 4drp_A(0.0735);4drq_A(0.0746);4w9p_E(0.0736);3o5p_A(0.071);3o5o_A(0.0808);3o5r_A(0.0699);3o5q_A(0.0688);3o5l_A(0.0805);3o5k_B(0.0817);3o5k_A(0.0791);3o5k_D(0.0722);3o5m_B(0.0826);3o5k_C(0.0809);3o5m_A(0.0831);3o5g_A(0.0816);3o5i_B(0.0804);3o5j_A(0.0893);3o5i_A(0.0788);3o5d_A(0.0907);3o5d_B(0.0954);3o5e_A(0.0866);4drk_A(0.0761);4dri_A(0.0855);4drn_A(0.0773);4dro_A(0.0709);4drk_B(0.0783);4drm_A(0.0657);4tx0_A(0.075);4tw6_A(0.0756);4tw7_A(0.0698);4w9p_A(0.0814);4w9q_A(0.0669);4jfi_A(0.0754);4w9o_E(0.0737);4jfk_A(0.0707);4jfj_A(0.065);4jfm_A(0.0669);4w9o_A(0.0754);4jfl_A(0.0697) Cluster-exclusive I:2 0.065 2 1 brca:2 ENST00000357266 4 3d FKBP5 K98 98 655 4drp_A(0.0735);4drq_A(0.0746);4w9p_E(0.0736);3o5p_A(0.071);3o5o_A(0.0808);3o5r_A(0.0699);3o5q_A(0.0688);3o5l_A(0.0805);3o5k_B(0.0817);3o5k_A(0.0791);3o5k_D(0.0722);3o5m_B(0.0826);3o5k_C(0.0809);3o5m_A(0.0831);3o5g_A(0.0816);3o5i_B(0.0804);3o5j_A(0.0893);3o5i_A(0.0788);3o5d_A(0.0907);3o5d_B(0.0954);3o5e_A(0.0866);4drk_A(0.0761);4dri_A(0.0855);4drn_A(0.0773);4dro_A(0.0709);4drk_B(0.0783);4drm_A(0.0657);4tx0_A(0.075);4tw6_A(0.0756);4tw7_A(0.0698);4w9p_A(0.0814);4w9q_A(0.0669);4jfi_A(0.0754);4w9o_E(0.0737);4jfk_A(0.0707);4jfj_A(0.065);4jfm_A(0.0669);4w9o_A(0.0754);4jfl_A(0.0697) Cluster-exclusive R:1 0.065 1 1 luad:1 ENST00000357266 4 3d CEP164 Q229 229 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive R:1 0.065 1 1 lihc:1 ENST00000278935 3 3d CEP164 C324 324 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive F:1 0.065 1 1 prad:1 ENST00000278935 3 3d CEP164 R325 325 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive W:1 0.065 1 1 lihc:1 ENST00000278935 3 3d CEP164 N326 326 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive Y:1 0.065 1 1 luad:1 ENST00000278935 3 3d CEP164 V328 328 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive G:1 0.065 1 1 skcm:1 ENST00000278935 3 3d CEP164 P334 334 656 2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive S:1 0.065 1 1 skcm:1 ENST00000278935 3 3d CEP164 H232 232 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive R:1 0.065 1 1 esca:1 ENST00000278935 3 3d H4C12 A90 90 658 3r45_B(0.0653) Cluster-exclusive T:1 0.0653 1 1 ov:1 ENST00000357549 2 3d H4C12 G95 95 658 3r45_B(0.0653) Cluster-exclusive S:1 0.0653 1 1 skcm:1 ENST00000357549 2 3d H4C12 R96 96 658 3r45_B(0.0653) Cluster-exclusive C:1 0.0653 1 1 lusc:1 ENST00000357549 2 3d PDXP P169 169 659 2p27_A(0.0724);2cft_A(0.0712);2cfs_A(0.0681);2p69_A(0.0709);2cfr_A(0.0709);2oyc_A(0.0653) Cluster-exclusive L:1 0.0653 1 1 lusc:1 ENST00000215904 6 3d PDXP E170 170 659 2p27_A(0.0724);2cft_A(0.0712);2cfs_A(0.0681);2p69_A(0.0709);2cfr_A(0.0709);2oyc_A(0.0653) Cluster-exclusive A:1 0.0653 1 1 stad:1 ENST00000215904 6 3d PDXP L172 172 659 2p27_A(0.0724);2cft_A(0.0712);2cfs_A(0.0681);2p69_A(0.0709);2cfr_A(0.0709);2oyc_A(0.0653) Cluster-exclusive Q:1 0.0653 1 1 luad:1 ENST00000215904 6 3d E2F5 D93 93 660 1cf7_A(0.0654) Cluster-exclusive N:1 0.0654 1 1 hnsc:1 ENST00000416274 2 3d E2F5 V97 97 660 1cf7_A(0.0654) Cluster-exclusive F:1 0.0654 1 1 luad:1 ENST00000416274 2 3d E2F5 E99 99 660 1cf7_A(0.0654) Cluster-exclusive G:1 0.0654 1 1 lihc:1 ENST00000416274 2 3d E2F5 G100 100 660 1cf7_A(0.0654) Cluster-exclusive R:1 0.0654 1 1 hnsc:1 ENST00000416274 2 3d RBP7 H53 53 661 1lpj_A(0.0656) Cluster-exclusive Y:1 0.0656 1 1 skcm:1 ENST00000294435 7 3d RBP7 T54 54 661 1lpj_A(0.0656) Cluster-exclusive K:1 0.0656 1 1 cscc:1 ENST00000294435 7 3d RBP7 N55 55 661 1lpj_A(0.0656) Cluster-exclusive S:1 0.0656 1 1 luad:1 ENST00000294435 7 3d RBP7 S57 57 661 1lpj_A(0.0656) Cluster-exclusive N:1 0.0656 1 1 stad:1 ENST00000294435 7 3d ETV6 R339 339 662 2dao_A(0.0657) Cluster-exclusive I:1 0.0657 1 1 mds:1 ENST00000396373 4 3d ETV6 G375 375 662 2dao_A(0.0657) Cluster-exclusive R:1 0.0657 1 1 ov:1 ENST00000396373 4 3d ETV6 A377 377 662 2dao_A(0.0657) Cluster-exclusive T:1 0.0657 1 1 paad:1 ENST00000396373 4 3d ETV6 R378 378 662 2dao_A(0.0657) Cluster-exclusive P:1 0.0657 1 1 brca:1 ENST00000396373 4 3d ETV6 W380 380 662 2dao_A(0.0657) Cluster-exclusive C:1 0.0657 1 1 coadread:1 ENST00000396373 4 3d ETV6 G381 381 662 2dao_A(0.0657) Cluster-exclusive E:1 0.0657 1 1 coadread:1 ENST00000396373 4 3d ETV6 N382 382 662 2dao_A(0.0657) Cluster-exclusive D:1 0.0657 1 1 brca:1 ENST00000396373 4 3d ETV6 R386 386 662 2dao_A(0.0657) Cluster-exclusive I:1 0.0657 1 1 coadread:1 ENST00000396373 4 3d EGFR E84 84 663 1yy9_A(0.0659);1nql_A(0.0672);3qwq_A(0.0694) Hotspot-linked V:1 0.0659 1 1 lgg:1 ENST00000275493 2 3d EGFR V85 85 663 1yy9_A(0.0659);1nql_A(0.0672);3qwq_A(0.0694) Hotspot-linked M:1 0.0659 1 1 stad:1 ENST00000275493 2 3d EGFR R108 108 663 1yy9_A(0.0659);1nql_A(0.0672);3qwq_A(0.0694) Hotspot G:1|K:7 0.0659 8 3 gbm:5|hgg:1|lgg:2 ENST00000275493 2 3d SETD2 C1516 1516 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive F:1|Y:1 0.0664 2 2 gbm:1|luad:1 ENST00000409792 3 3d SETD2 G1517 1517 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive V:1 0.0664 1 1 luad:1 ENST00000409792 3 3d SETD2 R1523 1523 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive C:1|H:1 0.0664 2 1 coadread:2 ENST00000409792 3 3d SETD2 S1540 1540 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive P:1 0.0664 1 1 skcm:1 ENST00000409792 3 3d SETD2 N1541 1541 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive S:2 0.0664 2 2 stad:1|luad:1 ENST00000409792 3 3d SETD2 W1640 1640 667 4fmu_A(0.0685);4h12_A(0.0664) Cluster-exclusive R:1|C:1 0.0664 2 1 kirc:2 ENST00000409792 3 3d TOX V265 265 668 2co9_A(0.0665) Cluster-exclusive L:1 0.0665 1 1 luad:1 ENST00000361421 1 3d TOX F272 272 668 2co9_A(0.0665) Cluster-exclusive L:1 0.0665 1 1 acc:1 ENST00000361421 1 3d TOX R273 273 668 2co9_A(0.0665) Cluster-exclusive C:4|H:1 0.0665 5 4 stad:1|skcm:1|ucec:2|cscc:1 ENST00000361421 1 3d TOX D274 274 668 2co9_A(0.0665) Cluster-exclusive Y:1|N:1 0.0665 2 2 brca:1|lusc:1 ENST00000361421 1 3d TOX T275 275 668 2co9_A(0.0665) Cluster-exclusive N:1 0.0665 1 1 coadread:1 ENST00000361421 1 3d TOX A277 277 668 2co9_A(0.0665) Cluster-exclusive V:1 0.0665 1 1 skcm:1 ENST00000361421 1 3d DDX19A I375 375 669 3g0h_A(0.0665);3fht_A(0.0753);3fht_B(0.0676) Cluster-exclusive L:1 0.0665 1 1 coadread:1 ENST00000302243 7 3d DDX19A R377 377 669 3g0h_A(0.0665);3fht_A(0.0753);3fht_B(0.0676) Cluster-exclusive C:1 0.0665 1 1 lusc:1 ENST00000302243 7 3d DDX19A R379 379 669 3g0h_A(0.0665);3fht_A(0.0753);3fht_B(0.0676) Cluster-exclusive Q:1 0.0665 1 1 ucec:1 ENST00000302243 7 3d DDX19A G381 381 669 3g0h_A(0.0665);3fht_A(0.0753);3fht_B(0.0676) Cluster-exclusive C:1 0.0665 1 1 stad:1 ENST00000302243 7 3d DDX19A D397 397 669 3g0h_A(0.0665);3fht_A(0.0753);3fht_B(0.0676) Cluster-exclusive H:1 0.0665 1 1 cesc:1 ENST00000302243 7 3d CAPN1 F341 341 670 1kxr_A(0.0668) Cluster-exclusive L:1 0.0668 1 1 kirp:1 ENST00000279247 6 3d CAPN1 R343 343 670 1kxr_A(0.0668) Cluster-exclusive L:1 0.0668 1 1 cll:1 ENST00000279247 6 3d CAPN1 E344 344 670 1kxr_A(0.0668) Cluster-exclusive G:1 0.0668 1 1 hnsc:1 ENST00000279247 6 3d F7 G156 156 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive D:1 0.0669 1 1 stad:1 ENST00000375581 3 3d F7 E159 159 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive Q:1 0.0669 1 1 cesc:1 ENST00000375581 3 3d F7 R170 170 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive C:1 0.0669 1 1 lgg:1 ENST00000375581 3 3d F7 C172 172 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive F:1 0.0669 1 1 cscc:1 ENST00000375581 3 3d F7 R173 173 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive W:1 0.0669 1 1 gbm:1 ENST00000375581 3 3d F7 G184 184 671 1wss_L(0.0835);2zp0_L(0.0957);1w8b_L(0.0669) Cluster-exclusive R:2 0.0669 2 2 skcm:1|luad:1 ENST00000375581 3 3d TBL1XR1 L363 363 672 2y9t_A(0.067) Cluster-exclusive V:1 0.067 1 1 blca:1 ENST00000430069 1 3d CRABP2 N15 15 673 2frs_A(0.067) Cluster-exclusive K:1 0.067 1 1 mmyl:1 ENST00000368221 1 3d CRABP2 E17 17 673 2frs_A(0.067) Cluster-exclusive D:1 0.067 1 1 ucec:1 ENST00000368221 1 3d CRABP2 E18 18 673 2frs_A(0.067) Cluster-exclusive D:1 0.067 1 1 stad:1 ENST00000368221 1 3d CRABP2 L20 20 673 2frs_A(0.067) Cluster-exclusive F:1 0.067 1 1 stad:1 ENST00000368221 1 3d ATP1A2 R938 938 674 3n23_A(0.0672) Cluster-exclusive H:1|L:1 0.0672 2 2 coadread:1|luad:1 ENST00000361216 3 3d ATP1A2 R1007 1007 674 3n23_A(0.0672) Cluster-exclusive P:1|Q:2|W:2 0.0672 5 5 paad:1|stad:1|hnsc:1|skcm:1|ov:1 ENST00000361216 3 3d ATP1A2 R1008 1008 674 3n23_A(0.0672) Cluster-exclusive Q:2|W:1 0.0672 3 3 stad:1|esca:1|lusc:1 ENST00000361216 3 3d ATP1A2 P1010 1010 674 3n23_A(0.0672) Cluster-exclusive S:1 0.0672 1 1 skcm:1 ENST00000361216 3 3d ATP1A2 E1015 1015 674 3n23_A(0.0672) Cluster-exclusive K:1 0.0672 1 1 cscc:1 ENST00000361216 3 3d PPP2R1A A136 136 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Cluster-exclusive T:1 0.0673 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A W140 140 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Cluster-exclusive C:1 0.0673 1 1 luad:1 ENST00000322088 6 3d PPP2R1A S143 143 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked F:1 0.0673 1 1 skcm:1 ENST00000322088 6 3d PPP2R1A R144 144 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked C:1|H:1 0.0673 2 2 ucec:1|lusc:1 ENST00000322088 6 3d PPP2R1A S146 146 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked L:3 0.0673 3 3 ucs:1|skcm:1|luad:1 ENST00000322088 6 3d PPP2R1A C148 148 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked F:1 0.0673 1 1 luad:1 ENST00000322088 6 3d LCAT G239 239 676 4x96_A(0.0712);4x96_C(0.0714);4x96_B(0.0729);4x96_D(0.0675) Cluster-exclusive V:2 0.0675 2 2 lihc:1|kirp:1 ENST00000264005 5 3d LCAT P278 278 676 4x96_A(0.0712);4x96_C(0.0714);4x96_B(0.0729);4x96_D(0.0675) Cluster-exclusive S:1 0.0675 1 1 cesc:1 ENST00000264005 5 3d LCAT S279 279 676 4x96_A(0.0712);4x96_C(0.0714);4x96_B(0.0729);4x96_D(0.0675) Cluster-exclusive C:1 0.0675 1 1 hnsc:1 ENST00000264005 5 3d LCAT R280 280 676 4x96_A(0.0712);4x96_C(0.0714);4x96_B(0.0729);4x96_D(0.0675) Cluster-exclusive H:1 0.0675 1 1 ucec:1 ENST00000264005 5 3d LCAT A282 282 676 4x96_A(0.0712);4x96_C(0.0714);4x96_B(0.0729);4x96_D(0.0675) Cluster-exclusive V:1 0.0675 1 1 ucec:1 ENST00000264005 5 3d DUSP8 Y189 189 677 4jmk_A(0.0678);4jmk_B(0.0786) Cluster-exclusive C:1 0.0678 1 1 esca:1 ENST00000331588 4 3d DUSP8 F231 231 677 4jmk_A(0.0678);4jmk_B(0.0786) Cluster-exclusive S:1 0.0678 1 1 stad:1 ENST00000331588 4 3d DUSP8 D233 233 677 4jmk_A(0.0678);4jmk_B(0.0786) Cluster-exclusive G:1 0.0678 1 1 ucec:1 ENST00000331588 4 3d DUSP8 K234 234 677 4jmk_A(0.0678);4jmk_B(0.0786) Cluster-exclusive T:1 0.0678 1 1 skcm:1 ENST00000331588 4 3d BRAF L505 505 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot-linked H:2 0.0679 2 2 prad:1|skcm:1 ENST00000288602 6 3d DCC Y343 343 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive F:1 0.0685 1 1 luad:1 ENST00000442544 2 3d DCC E344 344 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive K:1 0.0685 1 1 skcm:1 ENST00000442544 2 3d DCC S345 345 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive R:1 0.0685 1 1 luad:1 ENST00000442544 2 3d DCC E349 349 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive K:1 0.0685 1 1 skcm:1 ENST00000442544 2 3d DCC V380 380 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive L:1 0.0685 1 1 lusc:1 ENST00000442544 2 3d DCC G381 381 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive R:1 0.0685 1 1 skcm:1 ENST00000442544 2 3d DCC G382 382 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive E:1 0.0685 1 1 skcm:1 ENST00000442544 2 3d DCC L385 385 680 4b94_A(0.0685);4b94_B(0.0806) Cluster-exclusive V:1 0.0685 1 1 esca:1 ENST00000442544 2 3d AIFM3 G124 124 681 3fjl_A(0.0846);2b0m_A(0.0825);2prh_A(0.0787);2prl_A(0.0857);2prm_A(0.0853);3f1q_A(0.0772);2fqi_A(0.079);4igh_A(0.0917);3kvj_A(0.0762);3kvk_A(0.0806);3g0u_A(0.0763);3u2o_A(0.069);3kvl_A(0.0902);3kvm_A(0.0806);3fj6_A(0.0791);3g0x_A(0.0841);2fpv_A(0.089);2fpy_A(0.0808);2wv8_A(0.0838);1d3h_A(0.0801);1d3g_A(0.0757);2fpt_A(0.081);2bxv_A(0.086) Cluster-exclusive S:1 0.069 1 1 skcm:1 ENST00000399167 2 3d AIFM3 V126 126 681 3fjl_A(0.0846);2b0m_A(0.0825);2prh_A(0.0787);2prl_A(0.0857);2prm_A(0.0853);3f1q_A(0.0772);2fqi_A(0.079);4igh_A(0.0917);3kvj_A(0.0762);3kvk_A(0.0806);3g0u_A(0.0763);3u2o_A(0.069);3kvl_A(0.0902);3kvm_A(0.0806);3fj6_A(0.0791);3g0x_A(0.0841);2fpv_A(0.089);2fpy_A(0.0808);2wv8_A(0.0838);1d3h_A(0.0801);1d3g_A(0.0757);2fpt_A(0.081);2bxv_A(0.086) Cluster-exclusive M:1 0.069 1 1 cscc:1 ENST00000399167 2 3d AIFM3 P129 129 681 3fjl_A(0.0846);2b0m_A(0.0825);2prh_A(0.0787);2prl_A(0.0857);2prm_A(0.0853);3f1q_A(0.0772);2fqi_A(0.079);4igh_A(0.0917);3kvj_A(0.0762);3kvk_A(0.0806);3g0u_A(0.0763);3u2o_A(0.069);3kvl_A(0.0902);3kvm_A(0.0806);3fj6_A(0.0791);3g0x_A(0.0841);2fpv_A(0.089);2fpy_A(0.0808);2wv8_A(0.0838);1d3h_A(0.0801);1d3g_A(0.0757);2fpt_A(0.081);2bxv_A(0.086) Cluster-exclusive L:1 0.069 1 1 skcm:1 ENST00000399167 2 3d VHL N78 78 682 1lqb_C(0.0691) Hotspot S:3|D:2|Y:1 0.0691 6 2 paad:1|kirc:5 ENST00000256474 2 3d VHL R79 79 682 1lqb_C(0.0691) Hotspot-linked P:1|G:1 0.0691 2 2 lusc:1|kirc:1 ENST00000256474 2 3d VHL L101 101 682 1lqb_C(0.0691) Hotspot-linked P:1 0.0691 1 1 kirc:1 ENST00000256474 2 3d VHL N131 131 682 1lqb_C(0.0691) Hotspot-linked Y:1 0.0691 1 1 kirc:1 ENST00000256474 2 3d PTP4A1 W84 84 683 1xm2_D(0.0691) Cluster-exclusive L:1 0.0691 1 1 lihc:1 ENST00000370651 3 3d PTP4A1 V88 88 683 1xm2_D(0.0691) Cluster-exclusive M:1 0.0691 1 1 brca:1 ENST00000370651 3 3d PTP4A1 V113 113 683 1xm2_D(0.0691) Cluster-exclusive L:1 0.0691 1 1 paad:1 ENST00000370651 3 3d PTP4A1 V115 115 683 1xm2_D(0.0691) Cluster-exclusive D:1 0.0691 1 1 coadread:1 ENST00000370651 3 3d PTP4A1 A118 118 683 1xm2_D(0.0691) Cluster-exclusive E:1 0.0691 1 1 gbm:1 ENST00000370651 3 3d ITFG1 E376 376 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive Q:1|K:1 0.0693 2 2 lusm:1|hnsc:1 ENST00000320640 6 3d ITFG1 A377 377 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive V:1 0.0693 1 1 stad:1 ENST00000320640 6 3d ITFG1 A396 396 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive V:1 0.0693 1 1 stad:1 ENST00000320640 6 3d ITFG1 M397 397 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive I:1 0.0693 1 1 luad:1 ENST00000320640 6 3d ITFG1 V398 398 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive F:1 0.0693 1 1 luad:1 ENST00000320640 6 3d ITFG1 F401 401 684 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive L:1 0.0693 1 1 ucec:1 ENST00000320640 6 3d ITFG1 C374 374 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive R:1 0.0693 1 1 ucec:1 ENST00000320640 6 3d SALL3 A368 368 686 3lqm_B(0.0693);3lqm_A(0.0715) Cluster-exclusive T:1 0.0693 1 1 hnsc:1 ENST00000537592 2 3d SALL3 S369 369 686 3lqm_B(0.0693);3lqm_A(0.0715) Cluster-exclusive R:1 0.0693 1 1 nbl:1 ENST00000537592 2 3d SALL3 V371 371 686 3lqm_B(0.0693);3lqm_A(0.0715) Cluster-exclusive I:1 0.0693 1 1 stad:1 ENST00000537592 2 3d PCDHB8 R537 537 687 2kr6_A(0.0694) Cluster-exclusive H:1 0.0694 1 1 stad:1 ENST00000239444 2 3d PCDHB8 G538 538 687 2kr6_A(0.0694) Cluster-exclusive S:1 0.0694 1 1 stad:1 ENST00000239444 2 3d PCDHB8 S539 539 687 2kr6_A(0.0694) Cluster-exclusive N:1 0.0694 1 1 skcm:1 ENST00000239444 2 3d PCDHB8 P540 540 687 2kr6_A(0.0694) Cluster-exclusive L:2 0.0694 2 2 coadread:1|stad:1 ENST00000239444 2 3d PCDHB8 A541 541 687 2kr6_A(0.0694) Cluster-exclusive D:1 0.0694 1 1 ucec:1 ENST00000239444 2 3d PCDHB8 S543 543 687 2kr6_A(0.0694) Cluster-exclusive C:1 0.0694 1 1 luad:1 ENST00000239444 2 3d PCDHB8 S544 544 687 2kr6_A(0.0694) Cluster-exclusive N:1 0.0694 1 1 ucec:1 ENST00000239444 2 3d PCDHB8 E545 545 687 2kr6_A(0.0694) Cluster-exclusive D:1|K:1 0.0694 2 2 stad:1|cscc:1 ENST00000239444 2 3d PCDHB8 A546 546 687 2kr6_A(0.0694) Cluster-exclusive V:2 0.0694 2 2 stad:1|gbm:1 ENST00000239444 2 3d PCDHB8 A555 555 687 2kr6_A(0.0694) Cluster-exclusive T:1 0.0694 1 1 ucec:1 ENST00000239444 2 3d PCDHB8 D557 557 687 2kr6_A(0.0694) Cluster-exclusive N:1 0.0694 1 1 skcm:1 ENST00000239444 2 3d SOS1 I87 87 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive K:1 0.0694 1 1 kirc:1 ENST00000402219 2 3d SOS1 D89 89 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive N:1 0.0694 1 1 luad:1 ENST00000402219 2 3d SOS1 A90 90 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive T:1|V:1 0.0694 2 2 skcm:1|lusc:1 ENST00000402219 2 3d SOS1 S92 92 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive L:1 0.0694 1 1 skcm:1 ENST00000402219 2 3d SOS1 A93 93 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive D:1 0.0694 1 1 coadread:1 ENST00000402219 2 3d SOS1 V133 133 688 1q9c_F(0.0715);1q9c_E(0.0694);1q9c_H(0.0711);1q9c_G(0.0804);1q9c_I(0.0744);1q9c_B(0.0707);1q9c_A(0.0701);1q9c_D(0.0706);1q9c_C(0.071) Cluster-exclusive A:1 0.0694 1 1 luad:1 ENST00000402219 2 3d CBL E276 276 689 3vgo_A(0.0694);3pfv_A(0.0988) Cluster-exclusive K:3 0.0694 3 2 coadread:2|ucec:1 ENST00000264033 4 3d CBL A279 279 689 3vgo_A(0.0694);3pfv_A(0.0988) Cluster-exclusive T:1 0.0694 1 1 cscc:1 ENST00000264033 4 3d CBL R280 280 689 3vgo_A(0.0694);3pfv_A(0.0988) Cluster-exclusive W:1 0.0694 1 1 luad:1 ENST00000264033 4 3d CBL I292 292 689 3vgo_A(0.0694);3pfv_A(0.0988) Cluster-exclusive V:1 0.0694 1 1 lihc:1 ENST00000264033 4 3d PPARG E488 488 690 3et0_B(0.0696) Cluster-exclusive K:1 0.0696 1 1 luad:1 ENST00000287820 6 3d PPARG L493 493 690 3et0_B(0.0696) Cluster-exclusive F:1 0.0696 1 1 coadread:1 ENST00000287820 6 3d PPARG H494 494 690 3et0_B(0.0696) Cluster-exclusive Y:1 0.0696 1 1 blca:1 ENST00000287820 6 3d PPARG P495 495 690 3et0_B(0.0696) Cluster-exclusive R:1 0.0696 1 1 cscc:1 ENST00000287820 6 3d TEAD2 A84 84 691 2hzd_A(0.0697) Cluster-exclusive V:1 0.0697 1 1 stad:1 ENST00000311227 2 3d TEAD2 R85 85 691 2hzd_A(0.0697) Cluster-exclusive C:1|H:1 0.0697 2 2 mmyl:1|ucec:1 ENST00000311227 2 3d TEAD2 I87 87 691 2hzd_A(0.0697) Cluster-exclusive M:1 0.0697 1 1 luad:1 ENST00000311227 2 3d TEAD2 R95 95 691 2hzd_A(0.0697) Cluster-exclusive Q:1 0.0697 1 1 ov:1 ENST00000311227 2 3d TEAD2 R97 97 691 2hzd_A(0.0697) Cluster-exclusive Q:2 0.0697 2 2 stad:1|ucec:1 ENST00000311227 2 3d FLT1 A1007 1007 694 3hng_A(0.0699) Cluster-exclusive T:1 0.0699 1 1 ucec:1 ENST00000282397 4 3d FLT1 E1011 1011 694 3hng_A(0.0699) Cluster-exclusive K:1 0.0699 1 1 skcm:1 ENST00000282397 4 3d FLT1 S1014 1014 694 3hng_A(0.0699) Cluster-exclusive P:1|F:1 0.0699 2 2 brca:1|luad:1 ENST00000282397 4 3d FLT1 V1082 1082 694 3hng_A(0.0699) Cluster-exclusive M:1 0.0699 1 1 coadread:1 ENST00000282397 4 3d FLT1 Y1085 1085 694 3hng_A(0.0699) Cluster-exclusive C:1 0.0699 1 1 cscc:1 ENST00000282397 4 3d FLT1 R1146 1146 694 3hng_A(0.0699) Cluster-exclusive I:1 0.0699 1 1 ucec:1 ENST00000282397 4 3d FLT1 F1147 1147 694 3hng_A(0.0699) Cluster-exclusive C:1 0.0699 1 1 coadread:1 ENST00000282397 4 3d IL21R P122 122 695 4nzd_A(0.0703) Cluster-exclusive L:1 0.0703 1 1 cscc:1 ENST00000337929 3 3d IL21R P123 123 695 4nzd_A(0.0703) Cluster-exclusive T:1|L:1 0.0703 2 2 ov:1|skcm:1 ENST00000337929 3 3d IL21R S137 137 695 4nzd_A(0.0703) Cluster-exclusive F:1 0.0703 1 1 skcm:1 ENST00000337929 3 3d IL21R R139 139 695 4nzd_A(0.0703) Cluster-exclusive S:1|H:1 0.0703 2 2 acc:1|stad:1 ENST00000337929 3 3d IL21R E143 143 695 4nzd_A(0.0703) Cluster-exclusive K:3 0.0703 3 3 coadread:1|skcm:1|cscc:1 ENST00000337929 3 3d IL21R R181 181 695 4nzd_A(0.0703) Cluster-exclusive I:1 0.0703 1 1 ucec:1 ENST00000337929 3 3d ANOS1 K203 203 697 1zlg_A(0.0706) Cluster-exclusive T:2 0.0706 2 1 stad:2 ENST00000262648 3 3d ANOS1 E246 246 697 1zlg_A(0.0706) Cluster-exclusive K:1 0.0706 1 1 stad:1 ENST00000262648 3 3d ANOS1 R247 247 697 1zlg_A(0.0706) Cluster-exclusive Q:1 0.0706 1 1 acc:1 ENST00000262648 3 3d ANOS1 V248 248 697 1zlg_A(0.0706) Cluster-exclusive G:1 0.0706 1 1 mmyl:1 ENST00000262648 3 3d AXIN1 A804 804 698 1wsp_A(0.0707);1wsp_B(0.0721);2d5g_E(0.0834);2d5g_B(0.0778);2d5g_A(0.0775) Cluster-exclusive T:1 0.0707 1 1 stad:1 ENST00000262320 3 3d AXIN1 T806 806 698 1wsp_A(0.0707);1wsp_B(0.0721);2d5g_E(0.0834);2d5g_B(0.0778);2d5g_A(0.0775) Cluster-exclusive I:2 0.0707 2 1 lihc:2 ENST00000262320 3 3d AXIN1 F810 810 698 1wsp_A(0.0707);1wsp_B(0.0721);2d5g_E(0.0834);2d5g_B(0.0778);2d5g_A(0.0775) Cluster-exclusive L:1 0.0707 1 1 blca:1 ENST00000262320 3 3d AXIN1 D843 843 698 1wsp_A(0.0707);1wsp_B(0.0721);2d5g_E(0.0834);2d5g_B(0.0778);2d5g_A(0.0775) Cluster-exclusive A:1 0.0707 1 1 lihc:1 ENST00000262320 3 3d AXIN1 A845 845 698 1wsp_A(0.0707);1wsp_B(0.0721);2d5g_E(0.0834);2d5g_B(0.0778);2d5g_A(0.0775) Cluster-exclusive V:1 0.0707 1 1 coadread:1 ENST00000262320 3 3d MAP1B P2204 2204 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive S:1 0.0709 1 1 stad:1 ENST00000296755 7 3d MAP1B V2205 2205 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive M:1 0.0709 1 1 coadread:1 ENST00000296755 7 3d MAP1B S2209 2209 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive R:1|N:1 0.0709 2 2 ucec:1|luad:1 ENST00000296755 7 3d MAP1B P2210 2210 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive T:1 0.0709 1 1 luad:1 ENST00000296755 7 3d MAP1B R2213 2213 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive C:1|H:3 0.0709 4 3 paad:1|prad:1|stad:2 ENST00000296755 7 3d MAP1B T2243 2243 701 2pmv_B(0.0879);2pmv_A(0.0709) Cluster-exclusive I:1|N:1 0.0709 2 2 skcm:1|ucec:1 ENST00000296755 7 3d AP5B1 R578 578 702 2win_F(0.0768);3l5n_B(0.0792);2win_B(0.0741);2win_D(0.0709) Cluster-exclusive Q:1 0.0709 1 1 stad:1 ENST00000532090 2 3d AP5B1 R585 585 702 2win_F(0.0768);3l5n_B(0.0792);2win_B(0.0741);2win_D(0.0709) Cluster-exclusive L:1 0.0709 1 1 brca:1 ENST00000532090 2 3d AP5B1 A586 586 702 2win_F(0.0768);3l5n_B(0.0792);2win_B(0.0741);2win_D(0.0709) Cluster-exclusive E:1 0.0709 1 1 skcm:1 ENST00000532090 2 3d AP5B1 A612 612 702 2win_F(0.0768);3l5n_B(0.0792);2win_B(0.0741);2win_D(0.0709) Cluster-exclusive V:1 0.0709 1 1 brca:1 ENST00000532090 2 3d DPP4 A306 306 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive T:1 0.0711 1 1 ov:1 ENST00000360534 3 3d DPP4 E309 309 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive G:1 0.0711 1 1 ucec:1 ENST00000360534 3 3d DPP4 R310 310 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive G:1|I:1 0.0711 2 2 ov:1|ucec:1 ENST00000360534 3 3d DPP4 S312 312 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive Y:3 0.0711 3 2 coadread:1|ucec:2 ENST00000360534 3 3d DPP4 I327 327 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive T:1 0.0711 1 1 ucec:1 ENST00000360534 3 3d DPP4 W337 337 703 3c45_A(0.0814);3g0g_A(0.0851);1r9m_D(0.0885);3g0g_C(0.084);3c45_B(0.0843);1r9m_C(0.0863);2qt9_A(0.079);2qt9_B(0.0816);1r9m_B(0.0879);3g0g_B(0.0771);1r9m_A(0.0852);3vjl_A(0.0833);2oph_A(0.083);3g0g_D(0.0728);2oph_B(0.0805);3ccc_A(0.0896);3oc0_A(0.0783);3oc0_B(0.0749);3vjl_B(0.0823);1nu6_B(0.0799);2g63_D(0.0819);1nu6_A(0.0871);2g63_C(0.0807);2g63_B(0.0831);2g63_A(0.0844);3d4l_A(0.0834);2p8s_B(0.0824);2p8s_A(0.0795);3d4l_B(0.0881);1u8e_A(0.0855);3eio_B(0.0855);1u8e_B(0.0848);3eio_A(0.0787);4lko_A(0.0723);4lko_B(0.0718);1r9n_D(0.0863);1r9n_C(0.0858);1r9n_B(0.0833);1wcy_B(0.0814);1r9n_A(0.0775);1wcy_A(0.0831);3kwf_B(0.0834);3opm_D(0.0881);3opm_C(0.0864);3kwf_A(0.0772);3opm_B(0.0902);3opm_A(0.0878);3vjk_B(0.0828);4pnz_A(0.0807);4pnz_B(0.0858);3vjk_A(0.0817);4l72_A(0.0787);3ccb_A(0.0849);3ccb_B(0.0851);2rip_A(0.0745);2i78_B(0.0806);2i78_A(0.0801);2ogz_B(0.0821);2ogz_A(0.0845);2i78_D(0.0746);2iit_B(0.0807);2iit_A(0.0861);2i78_C(0.0817);2qtb_A(0.0844);2qtb_B(0.0811);4g1f_D(0.0855);4g1f_C(0.083);2oqi_A(0.0845);4g1f_B(0.092);4g1f_A(0.0871);2rgu_B(0.0807);2rgu_A(0.0743);2oqi_D(0.0817);2oqi_C(0.0804);2oqi_B(0.0881);1tkr_A(0.0838);1tkr_B(0.0803);4jh0_B(0.0805);4jh0_A(0.0752);1nu8_B(0.0861);1nu8_A(0.0744);2qoe_B(0.0877);2qoe_A(0.0832);2bgr_B(0.0759);2bgr_A(0.08);3g0b_B(0.0967);3g0b_A(0.0964);3g0b_D(0.0894);3g0b_C(0.0902);1j2e_B(0.0865);3qbj_B(0.0797);2g5p_B(0.0838);3qbj_A(0.0816);2g5p_A(0.0813);1j2e_A(0.0849);2i03_A(0.0762);2i03_B(0.0843);2hha_A(0.0848);2i03_C(0.0809);2hha_B(0.0821);2i03_D(0.0855);3sww_B(0.0763);3sww_A(0.0801);2fjp_B(0.0812);2fjp_A(0.0828);3vjm_B(0.0836);3vjm_A(0.0803);4j3j_A(0.0775);4j3j_B(0.082);3g0c_A(0.0804);3g0c_C(0.0842);3g0c_B(0.0812);3g0c_D(0.0779);2oqv_B(0.0754);2oqv_A(0.0829);4qzv_C(0.0824);1x70_A(0.0833);1x70_B(0.0833);2qky_A(0.0845);4qzv_A(0.0824);4dsa_A(0.0802);4dsa_B(0.0843);1n1m_A(0.085);1n1m_B(0.0821);3o9v_D(0.0814);3o95_C(0.0885);3g0d_B(0.0805);3o9v_C(0.0768);3g0d_A(0.0846);3o95_D(0.0906);3o9v_B(0.0828);3g0d_D(0.0746);3o95_A(0.0854);3o9v_A(0.0756);3o95_B(0.0926);3g0d_C(0.0776);4n8d_B(0.0891);3kwj_B(0.0799);4n8d_A(0.0827);3kwj_A(0.0771);4dtc_B(0.0753);4dtc_A(0.0781);3hab_A(0.0845);3hab_B(0.0874);2ole_B(0.0826);2ole_A(0.0858);1pfq_B(0.0762);1pfq_A(0.0727);4a5s_A(0.0766);4a5s_B(0.0879);4dsz_B(0.078);4dsz_A(0.0772);2bub_B(0.0761);3c43_B(0.0823);3c43_A(0.0807);3q8w_A(0.0737);3sx4_B(0.0732);4n8e_A(0.0798);3sx4_A(0.0748);4n8e_B(0.08);2bub_A(0.0802);3h0c_A(0.078);3h0c_B(0.0719);2onc_C(0.08);3hac_B(0.0869);2onc_D(0.0803);3hac_A(0.0809);2onc_B(0.0848);2ajl_I(0.0807);4pv7_A(0.082);4kr0_A(0.0815);2ajl_J(0.0793);2qjr_A(0.0816);2qjr_B(0.0774);3q8w_B(0.0765);2bgn_D(0.0723);2bgn_C(0.0724);2bgn_B(0.0785);2bgn_A(0.0745);1w1i_C(0.0711);2g5t_B(0.0773);1w1i_D(0.0785);2g5t_A(0.0769);1w1i_A(0.0785);1w1i_B(0.079);3w2t_A(0.0777);3w2t_B(0.0845);3bjm_B(0.0817);3bjm_A(0.0809);2jid_A(0.0861);3nox_B(0.077);2jid_B(0.0744);3nox_A(0.0752);4pv7_B(0.0813);1rwq_B(0.0807);1rwq_A(0.076);2iiv_B(0.0859);2iiv_A(0.0848);3f8s_B(0.0812);3f8s_A(0.0808);3q0t_B(0.0778);3q0t_A(0.0796);2oag_D(0.0855);2oag_A(0.0801);2oag_B(0.082);2oag_C(0.086);1tk3_A(0.0751);1tk3_B(0.077) Cluster-exclusive C:1 0.0711 1 1 luad:1 ENST00000360534 3 3d PECR L287 287 705 1yxm_C(0.0713) Cluster-exclusive P:1 0.0713 1 1 brca:1 ENST00000265322 7 3d PECR V290 290 705 1yxm_C(0.0713) Cluster-exclusive I:1 0.0713 1 1 lgg:1 ENST00000265322 7 3d PECR K291 291 705 1yxm_C(0.0713) Cluster-exclusive E:1 0.0713 1 1 lihc:1 ENST00000265322 7 3d PECR E295 295 705 1yxm_C(0.0713) Cluster-exclusive K:1 0.0713 1 1 cscc:1 ENST00000265322 7 3d SOCS5 R429 429 706 2izv_A(0.0714) Cluster-exclusive Q:4|L:1 0.0714 5 5 paad:1|ov:1|lihc:1|ucec:1|lusc:1 ENST00000306503 5 3d SOCS5 E431 431 706 2izv_A(0.0714) Cluster-exclusive Q:1 0.0714 1 1 hnsc:1 ENST00000306503 5 3d SOCS5 N436 436 706 2izv_A(0.0714) Cluster-exclusive K:1 0.0714 1 1 stad:1 ENST00000306503 5 3d SOCS5 A441 441 706 2izv_A(0.0714) Cluster-exclusive V:1 0.0714 1 1 ucec:1 ENST00000306503 5 3d SOCS5 H442 442 706 2izv_A(0.0714) Cluster-exclusive Y:1 0.0714 1 1 skcm:1 ENST00000306503 5 3d H2BC9 V67 67 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive D:1 0.0715 1 1 acc:1 ENST00000619466 3d H2BC9 N68 68 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive S:1 0.0715 1 1 stad:1 ENST00000619466 3d H2BC9 D69 69 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive H:1|N:1 0.0715 2 2 ucec:1|luad:1 ENST00000619466 3d H2BC9 E72 72 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive Q:1|K:1 0.0715 2 2 hnsc:1|skcm:1 ENST00000619466 3d H2BC9 I74 74 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive M:1 0.0715 1 1 blca:1 ENST00000619466 3d H2BC9 E77 77 707 1f66_D(0.0837);3b6g_H(0.0797);1p3b_D(0.0896);4j8v_D(0.0868);1p34_H(0.0852);1p3b_H(0.087);4j8x_D(0.0887);3tu4_D(0.0968);1p3f_H(0.0936);1p3l_D(0.0733);1p3o_D(0.0878);3kuy_D(0.0803);1p3k_H(0.0793);1p3m_H(0.0746);3mnn_D(0.0872);3w97_H(0.0951);1u35_H(0.0759);1u35_D(0.0861);3rej_H(0.0799);3rel_H(0.0791);3mvd_D(0.0896);3rel_D(0.0865);3c1c_H(0.0909);3uta_D(0.0788);3reh_D(0.0881);3mgp_H(0.0769);1m18_D(0.0924);3mgr_D(0.0877);3mgp_D(0.0825);3ut9_D(0.0944);3b6f_D(0.0715);1s32_H(0.0817);3waa_D(0.0958);4ld9_H(0.097);3b6f_H(0.0741);1s32_D(0.0905);1p3a_D(0.0846);4j8u_D(0.0827);4j8w_D(0.0859);1p3a_H(0.0749);1p3i_D(0.0829);1p3g_H(0.0783);1p3k_D(0.0822);3ut9_H(0.0837);1p3m_D(0.0879);1p3i_H(0.075);1p3l_H(0.0859);1p3p_D(0.0945);1kx4_D(0.086);3kxb_D(0.0888);1zla_D(0.0967);2f8n_D(0.0775);3lz0_D(0.0812);1p3p_H(0.0784);3w98_D(0.0998);1kx4_H(0.0933);1zbb_D(0.09);3lel_D(0.0904);1zbb_H(0.0882);2aro_B(0.097);3rek_H(0.0883);3c1b_D(0.0943);3rek_D(0.0843);3utb_H(0.0814);3c1b_H(0.0933);2f8n_H(0.0848);3mgq_H(0.0824);3mgs_D(0.0824);1m19_D(0.0855) Cluster-exclusive K:3 0.0715 3 3 brca:1|lusc:1|luad:1 ENST00000619466 3d IL6ST L255 255 708 1p9m_A(0.0717);1i1r_A(0.0807) Cluster-exclusive I:1 0.0717 1 1 gbc:1 ENST00000336909 5 3d IL6ST K256 256 708 1p9m_A(0.0717);1i1r_A(0.0807) Cluster-exclusive Q:1 0.0717 1 1 ucec:1 ENST00000336909 5 3d IL6ST N258 258 708 1p9m_A(0.0717);1i1r_A(0.0807) Cluster-exclusive S:2 0.0717 2 1 lihc:2 ENST00000336909 5 3d IL6ST S279 279 708 1p9m_A(0.0717);1i1r_A(0.0807) Cluster-exclusive C:1|F:1 0.0717 2 2 brca:1|skcm:1 ENST00000336909 5 3d IL6ST C301 301 708 1p9m_A(0.0717);1i1r_A(0.0807) Cluster-exclusive G:1 0.0717 1 1 skcm:1 ENST00000336909 5 3d IL6ST N223 223 709 1p9m_A(0.0717) Cluster-exclusive S:1|Y:1 0.0717 2 2 kirc:1|luad:1 ENST00000336909 5 3d AMY1C F330 330 713 1b2y_A(0.0916);2cpu_A(0.0931);3ole_A(0.0951);3old_A(0.0981);1kb3_A(0.0944);4gqq_A(0.097);1kbk_A(0.0902);4gqr_A(0.0952);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);3bay_A(0.0913);1xd0_A(0.0851);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);3ij7_A(0.0896);1xh1_A(0.0885);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);3bai_A(0.0903);1u33_A(0.0923);1mfu_A(0.0986);3bak_A(0.0943);2qmk_A(0.0959);3baj_A(0.0824);1u30_A(0.0939);1c8q_A(0.0988);1jxj_A(0.0972);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);1xcx_A(0.0892);3cpu_A(0.092);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive V:1 0.0723 1 1 skcm:1 ENST00000370079 3 3d CUL1 P419 419 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive L:1 0.0724 1 1 skcm:1 ENST00000325222 4 3d CUL1 E420 420 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive K:1 0.0724 1 1 blca:1 ENST00000325222 4 3d CUL1 V461 461 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive G:1 0.0724 1 1 luad:1 ENST00000325222 4 3d CUL1 Q463 463 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive H:1 0.0724 1 1 luad:1 ENST00000325222 4 3d CUL1 K464 464 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive T:1 0.0724 1 1 stad:1 ENST00000325222 4 3d CUL1 Y466 466 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive S:1 0.0724 1 1 coadread:1 ENST00000325222 4 3d CUL1 R707 707 714 3rtr_G(0.0724);1ldj_A(0.0898) Cluster-exclusive H:1 0.0724 1 1 stad:1 ENST00000325222 4 3d MATN3 G355 355 715 4kzz_A(0.0724);4kzy_A(0.0793);4kzx_A(0.0774) Cluster-exclusive C:1 0.0724 1 1 lusc:1 ENST00000407540 3 3d MATN3 G358 358 715 4kzz_A(0.0724);4kzy_A(0.0793);4kzx_A(0.0774) Cluster-exclusive V:1 0.0724 1 1 all:1 ENST00000407540 3 3d MATN3 C359 359 715 4kzz_A(0.0724);4kzy_A(0.0793);4kzx_A(0.0774) Cluster-exclusive Y:1 0.0724 1 1 luad:1 ENST00000407540 3 3d MATN3 R367 367 715 4kzz_A(0.0724);4kzy_A(0.0793);4kzx_A(0.0774) Cluster-exclusive I:1 0.0724 1 1 ucs:1 ENST00000407540 3 3d MOB1B A111 111 716 1pi1_A(0.0726);1r3b_A(0.0834) Cluster-exclusive T:1 0.0726 1 1 coadread:1 ENST00000309395 2 3d MOB1B Y114 114 716 1pi1_A(0.0726);1r3b_A(0.0834) Cluster-exclusive C:1 0.0726 1 1 brca:1 ENST00000309395 2 3d MOB1B I115 115 716 1pi1_A(0.0726);1r3b_A(0.0834) Cluster-exclusive T:1 0.0726 1 1 skcm:1 ENST00000309395 2 3d MOB1B M119 119 716 1pi1_A(0.0726);1r3b_A(0.0834) Cluster-exclusive T:1 0.0726 1 1 ov:1 ENST00000309395 2 3d MOB1B H161 161 716 1pi1_A(0.0726);1r3b_A(0.0834) Cluster-exclusive D:1 0.0726 1 1 hnsc:1 ENST00000309395 2 3d PLEKHH1 Y717 717 717 4hna_A(0.0915);3hkd_C(0.0869);3hke_C(0.0883);3hkd_A(0.0851);3hkb_C(0.0936);3hke_A(0.0895);3hkc_C(0.0873);4f61_C(0.0889);4f6r_A(0.092);1sa1_C(0.0838);4drx_C(0.0942);3ut5_A(0.0826);3du7_C(0.0818);3j1t_B(0.0793);1sa1_A(0.0887);4drx_A(0.0969);3ut5_C(0.0931);3j1u_B(0.0726);3du7_A(0.0791);1sa0_C(0.0887);1sa0_A(0.078);3hkb_A(0.0923);4f61_A(0.0941);3hkc_A(0.0898);3edl_F(0.0844);2xrp_B(0.0874);3ryf_A(0.0911);3ryc_C(0.0898);3ryc_A(0.0915);4eb6_C(0.0767);1z2b_C(0.0876);3ryh_C(0.0889);3ryi_C(0.0921);3n2k_C(0.0902);3ryf_C(0.0988);3ryh_A(0.091);3ryi_A(0.0899);1z2b_A(0.0844);4atu_B(0.0907);3e22_A(0.0853);3n2g_C(0.0864);3e22_C(0.0845);3n2k_A(0.0896);4abo_B(0.0849);4atx_B(0.0873);4eb6_A(0.0901);3n2g_A(0.0864) Cluster-exclusive S:1 0.0726 1 1 brca:1 ENST00000329153 5 3d PLEKHH1 H761 761 717 4hna_A(0.0915);3hkd_C(0.0869);3hke_C(0.0883);3hkd_A(0.0851);3hkb_C(0.0936);3hke_A(0.0895);3hkc_C(0.0873);4f61_C(0.0889);4f6r_A(0.092);1sa1_C(0.0838);4drx_C(0.0942);3ut5_A(0.0826);3du7_C(0.0818);3j1t_B(0.0793);1sa1_A(0.0887);4drx_A(0.0969);3ut5_C(0.0931);3j1u_B(0.0726);3du7_A(0.0791);1sa0_C(0.0887);1sa0_A(0.078);3hkb_A(0.0923);4f61_A(0.0941);3hkc_A(0.0898);3edl_F(0.0844);2xrp_B(0.0874);3ryf_A(0.0911);3ryc_C(0.0898);3ryc_A(0.0915);4eb6_C(0.0767);1z2b_C(0.0876);3ryh_C(0.0889);3ryi_C(0.0921);3n2k_C(0.0902);3ryf_C(0.0988);3ryh_A(0.091);3ryi_A(0.0899);1z2b_A(0.0844);4atu_B(0.0907);3e22_A(0.0853);3n2g_C(0.0864);3e22_C(0.0845);3n2k_A(0.0896);4abo_B(0.0849);4atx_B(0.0873);4eb6_A(0.0901);3n2g_A(0.0864) Cluster-exclusive Y:1 0.0726 1 1 luad:1 ENST00000329153 5 3d PLEKHH1 T763 763 717 4hna_A(0.0915);3hkd_C(0.0869);3hke_C(0.0883);3hkd_A(0.0851);3hkb_C(0.0936);3hke_A(0.0895);3hkc_C(0.0873);4f61_C(0.0889);4f6r_A(0.092);1sa1_C(0.0838);4drx_C(0.0942);3ut5_A(0.0826);3du7_C(0.0818);3j1t_B(0.0793);1sa1_A(0.0887);4drx_A(0.0969);3ut5_C(0.0931);3j1u_B(0.0726);3du7_A(0.0791);1sa0_C(0.0887);1sa0_A(0.078);3hkb_A(0.0923);4f61_A(0.0941);3hkc_A(0.0898);3edl_F(0.0844);2xrp_B(0.0874);3ryf_A(0.0911);3ryc_C(0.0898);3ryc_A(0.0915);4eb6_C(0.0767);1z2b_C(0.0876);3ryh_C(0.0889);3ryi_C(0.0921);3n2k_C(0.0902);3ryf_C(0.0988);3ryh_A(0.091);3ryi_A(0.0899);1z2b_A(0.0844);4atu_B(0.0907);3e22_A(0.0853);3n2g_C(0.0864);3e22_C(0.0845);3n2k_A(0.0896);4abo_B(0.0849);4atx_B(0.0873);4eb6_A(0.0901);3n2g_A(0.0864) Cluster-exclusive P:1 0.0726 1 1 brca:1 ENST00000329153 5 3d PLEKHH1 I766 766 717 4hna_A(0.0915);3hkd_C(0.0869);3hke_C(0.0883);3hkd_A(0.0851);3hkb_C(0.0936);3hke_A(0.0895);3hkc_C(0.0873);4f61_C(0.0889);4f6r_A(0.092);1sa1_C(0.0838);4drx_C(0.0942);3ut5_A(0.0826);3du7_C(0.0818);3j1t_B(0.0793);1sa1_A(0.0887);4drx_A(0.0969);3ut5_C(0.0931);3j1u_B(0.0726);3du7_A(0.0791);1sa0_C(0.0887);1sa0_A(0.078);3hkb_A(0.0923);4f61_A(0.0941);3hkc_A(0.0898);3edl_F(0.0844);2xrp_B(0.0874);3ryf_A(0.0911);3ryc_C(0.0898);3ryc_A(0.0915);4eb6_C(0.0767);1z2b_C(0.0876);3ryh_C(0.0889);3ryi_C(0.0921);3n2k_C(0.0902);3ryf_C(0.0988);3ryh_A(0.091);3ryi_A(0.0899);1z2b_A(0.0844);4atu_B(0.0907);3e22_A(0.0853);3n2g_C(0.0864);3e22_C(0.0845);3n2k_A(0.0896);4abo_B(0.0849);4atx_B(0.0873);4eb6_A(0.0901);3n2g_A(0.0864) Cluster-exclusive V:1|M:1 0.0726 2 2 ucec:1|cesc:1 ENST00000329153 5 3d C10ORF71 P119 119 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive S:1 0.0728 1 1 luad:1 ENST00000374144 3 3d PTPRF K204 204 719 2yd3_A(0.0731) Cluster-exclusive R:1 0.0731 1 1 lihc:1 ENST00000359947 4 3d PTPRF E206 206 719 2yd3_A(0.0731) Cluster-exclusive K:1 0.0731 1 1 skcm:1 ENST00000359947 4 3d PTPRF P220 220 719 2yd3_A(0.0731) Cluster-exclusive S:1 0.0731 1 1 luad:1 ENST00000359947 4 3d PTPRF A221 221 719 2yd3_A(0.0731) Cluster-exclusive V:1 0.0731 1 1 stad:1 ENST00000359947 4 3d UBE2E2 P79 79 720 1y6l_A(0.0732);1y6l_B(0.078);1y6l_C(0.0762);3bzh_A(0.0764) Cluster-exclusive T:1 0.0732 1 1 coadread:1 ENST00000396703 1 3d UBE2E2 R88 88 720 1y6l_A(0.0732);1y6l_B(0.078);1y6l_C(0.0762);3bzh_A(0.0764) Cluster-exclusive K:1 0.0732 1 1 coadread:1 ENST00000396703 1 3d UBE2E2 T90 90 720 1y6l_A(0.0732);1y6l_B(0.078);1y6l_C(0.0762);3bzh_A(0.0764) Cluster-exclusive S:1 0.0732 1 1 lusc:1 ENST00000396703 1 3d UBE2E2 F105 105 720 1y6l_A(0.0732);1y6l_B(0.078);1y6l_C(0.0762);3bzh_A(0.0764) Cluster-exclusive S:1 0.0732 1 1 kirc:1 ENST00000396703 1 3d UBE2E2 R124 124 720 1y6l_A(0.0732);1y6l_B(0.078);1y6l_C(0.0762);3bzh_A(0.0764) Cluster-exclusive L:1 0.0732 1 1 luad:1 ENST00000396703 1 3d H3C13 D107 107 721 4ld9_A(0.0732) Cluster-exclusive H:1 0.0732 1 1 luad:1 ENST00000331491 1 3d H3C13 T119 119 721 4ld9_A(0.0732) Cluster-exclusive A:1 0.0732 1 1 lihc:1 ENST00000331491 1 3d SMURF2 K38 38 722 3pyc_A(0.0732) Cluster-exclusive E:1 0.0732 1 1 lihc:1 ENST00000262435 9 3d SMURF2 D42 42 722 3pyc_A(0.0732) Cluster-exclusive H:1 0.0732 1 1 cesc:1 ENST00000262435 9 3d SMURF2 T76 76 722 3pyc_A(0.0732) Cluster-exclusive M:1 0.0732 1 1 hnsc:1 ENST00000262435 9 3d SMURF2 R98 98 722 3pyc_A(0.0732) Cluster-exclusive H:1 0.0732 1 1 stad:1 ENST00000262435 9 3d MKX V132 132 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive A:1 0.0733 1 1 skcm:1 ENST00000375790 5 3d MKX R133 133 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive Q:1 0.0733 1 1 esca:1 ENST00000375790 5 3d MKX D168 168 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive N:1 0.0733 1 1 skcm:1 ENST00000375790 5 3d MKX E170 170 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive K:1 0.0733 1 1 skcm:1 ENST00000375790 5 3d MKX R174 174 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive T:1 0.0733 1 1 blca:1 ENST00000375790 5 3d MKX S196 196 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive L:5 0.0733 5 3 brca:1|skcm:3|cscc:1 ENST00000375790 5 3d MKX R225 225 723 4b3f_X(0.0867);4b3g_A(0.0733) Cluster-exclusive H:2 0.0733 2 2 stad:1|esca:1 ENST00000375790 5 3d CENPA A129 129 725 3r45_A(0.0734) Cluster-exclusive T:1 0.0734 1 1 stad:1 ENST00000335756 4 3d CENPA R130 130 725 3r45_A(0.0734) Cluster-exclusive Q:1|W:1|L:1 0.0734 3 2 lgg:1|luad:2 ENST00000335756 4 3d CENPA R133 133 725 3r45_A(0.0734) Cluster-exclusive W:1|L:1 0.0734 2 2 skcm:1|luad:1 ENST00000335756 4 3d CENPA G138 138 725 3r45_A(0.0734) Cluster-exclusive R:1 0.0734 1 1 cscc:1 ENST00000335756 4 3d PTPN11 I463 463 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot-linked L:1 0.0735 1 1 ucec:1 ENST00000351677 2 3d ING2 G227 227 727 1wes_A(0.0737) Cluster-exclusive R:1 0.0737 1 1 coadread:1 ENST00000302327 3 3d ING2 P249 249 727 1wes_A(0.0737) Cluster-exclusive S:1 0.0737 1 1 skcm:1 ENST00000302327 3 3d ING2 W253 253 727 1wes_A(0.0737) Cluster-exclusive C:2 0.0737 2 2 hnsc:1|ov:1 ENST00000302327 3 3d ING2 Y254 254 727 1wes_A(0.0737) Cluster-exclusive H:1 0.0737 1 1 ucec:1 ENST00000302327 3 3d KIF1A R153 153 728 4uxs_C(0.0922);4uxo_C(0.0738);4uxp_C(0.0849);4uxr_C(0.0834) Cluster-exclusive H:2 0.0738 2 2 ucec:1|kirc:1 ENST00000320389 7 3d KIF1A V154 154 728 4uxs_C(0.0922);4uxo_C(0.0738);4uxp_C(0.0849);4uxr_C(0.0834) Cluster-exclusive F:1|I:1 0.0738 2 2 kirp:1|luad:1 ENST00000320389 7 3d KIF1A R155 155 728 4uxs_C(0.0922);4uxo_C(0.0738);4uxp_C(0.0849);4uxr_C(0.0834) Cluster-exclusive C:1 0.0738 1 1 skcm:1 ENST00000320389 7 3d PACSIN3 A58 58 729 3syv_F(0.0763);3m3w_A(0.0869);3syv_G(0.0758);3m3w_B(0.093);3syv_H(0.0738);3syv_B(0.0817);3syv_C(0.075);3syv_D(0.0837);3syv_E(0.0788);3syv_A(0.0752);3qe6_B(0.0944);3qe6_A(0.0926) Cluster-exclusive D:1|V:1 0.0738 2 2 stad:1|skcm:1 ENST00000298838 6 3d PACSIN3 A61 61 729 3syv_F(0.0763);3m3w_A(0.0869);3syv_G(0.0758);3m3w_B(0.093);3syv_H(0.0738);3syv_B(0.0817);3syv_C(0.075);3syv_D(0.0837);3syv_E(0.0788);3syv_A(0.0752);3qe6_B(0.0944);3qe6_A(0.0926) Cluster-exclusive T:1 0.0738 1 1 paad:1 ENST00000298838 6 3d PACSIN3 K63 63 729 3syv_F(0.0763);3m3w_A(0.0869);3syv_G(0.0758);3m3w_B(0.093);3syv_H(0.0738);3syv_B(0.0817);3syv_C(0.075);3syv_D(0.0837);3syv_E(0.0788);3syv_A(0.0752);3qe6_B(0.0944);3qe6_A(0.0926) Cluster-exclusive N:1 0.0738 1 1 luad:1 ENST00000298838 6 3d PACSIN3 A88 88 729 3syv_F(0.0763);3m3w_A(0.0869);3syv_G(0.0758);3m3w_B(0.093);3syv_H(0.0738);3syv_B(0.0817);3syv_C(0.075);3syv_D(0.0837);3syv_E(0.0788);3syv_A(0.0752);3qe6_B(0.0944);3qe6_A(0.0926) Cluster-exclusive T:1 0.0738 1 1 blca:1 ENST00000298838 6 3d DCLRE1B H163 163 730 5aho_A(0.0739) Cluster-exclusive R:1|Y:1 0.0739 2 2 ucs:1|skcm:1 ENST00000369563 3 3d DCLRE1B L168 168 730 5aho_A(0.0739) Cluster-exclusive P:1 0.0739 1 1 lihc:1 ENST00000369563 3 3d DCLRE1B R170 170 730 5aho_A(0.0739) Cluster-exclusive Q:2 0.0739 2 2 coadread:1|lihc:1 ENST00000369563 3 3d DCLRE1B H172 172 730 5aho_A(0.0739) Cluster-exclusive P:1 0.0739 1 1 luad:1 ENST00000369563 3 3d DCLRE1B H269 269 730 5aho_A(0.0739) Cluster-exclusive N:1 0.0739 1 1 stad:1 ENST00000369563 3 3d NDST3 S627 627 734 3vn4_A(0.0805);3ghm_A(0.0742);3ghn_A(0.079) Cluster-exclusive R:1 0.0742 1 1 lihc:1 ENST00000296499 5 3d NDST3 K629 629 734 3vn4_A(0.0805);3ghm_A(0.0742);3ghn_A(0.079) Cluster-exclusive Q:1|N:1 0.0742 2 2 coadread:1|stad:1 ENST00000296499 5 3d NDST3 E632 632 734 3vn4_A(0.0805);3ghm_A(0.0742);3ghn_A(0.079) Cluster-exclusive Q:1 0.0742 1 1 brca:1 ENST00000296499 5 3d NDST3 R644 644 734 3vn4_A(0.0805);3ghm_A(0.0742);3ghn_A(0.079) Cluster-exclusive M:2 0.0742 2 2 stad:1|ucec:1 ENST00000296499 5 3d NDST3 D651 651 734 3vn4_A(0.0805);3ghm_A(0.0742);3ghn_A(0.079) Cluster-exclusive N:1 0.0742 1 1 lusc:1 ENST00000296499 5 3d CDH1 E165 165 735 2o72_A(0.0744) Cluster-exclusive Q:1 0.0744 1 1 brca:1 ENST00000261769 5 3d CDH1 D221 221 735 2o72_A(0.0744) Cluster-exclusive V:1 0.0744 1 1 ov:1 ENST00000261769 5 3d CDH1 R224 224 735 2o72_A(0.0744) Cluster-exclusive H:2 0.0744 2 2 hnsc:1|ucec:1 ENST00000261769 5 3d SMAD4 R380 380 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked K:1 0.0749 1 1 coadread:1 ENST00000342988 3 3d SMAD4 H382 382 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked D:1|L:2 0.0749 3 2 paad:2|stad:1 ENST00000342988 3 3d SMAD4 F505 505 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked Y:1 0.0749 1 1 coadread:1 ENST00000342988 3 3d SMAD4 C523 523 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked 0.0749 1 ENST00000342988 3 3d KLHL3 T429 429 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive M:2 0.0749 2 2 acc:1|stad:1 ENST00000309755 4 3d KLHL3 R430 430 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive W:1 0.0749 1 1 cll:1 ENST00000309755 4 3d KLHL3 R431 431 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive W:1 0.0749 1 1 coadread:1 ENST00000309755 4 3d KLHL3 G490 490 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive R:1 0.0749 1 1 stad:1 ENST00000309755 4 3d KLHL3 Y493 493 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive H:1 0.0749 1 1 coadread:1 ENST00000309755 4 3d KLHL3 A494 494 738 3ubd_A(0.0749);4gue_A(0.0808);4el9_A(0.0839) Cluster-exclusive T:1 0.0749 1 1 coadread:1 ENST00000309755 4 3d KDR L161 161 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive R:1 0.0752 1 1 stad:1 ENST00000263923 4 3d KDR A163 163 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive E:2 0.0752 2 1 luad:2 ENST00000263923 4 3d KDR R164 164 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive I:1 0.0752 1 1 ucec:1 ENST00000263923 4 3d KDR K168 168 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive N:1 0.0752 1 1 ucs:1 ENST00000263923 4 3d KDR F170 170 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive I:1 0.0752 1 1 luad:1 ENST00000263923 4 3d KDR A195 195 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive S:1 0.0752 1 1 brca:1 ENST00000263923 4 3d KDR M197 197 739 3v6b_R(0.0757);3v2a_R(0.0752) Cluster-exclusive I:1|K:1 0.0752 2 1 luad:2 ENST00000263923 4 3d SELE C143 143 740 1g1t_A(0.0752) Cluster-exclusive F:1 0.0752 1 1 skcm:1 ENST00000333360 7 3d SELE T144 144 740 1g1t_A(0.0752) Cluster-exclusive I:1 0.0752 1 1 hnsc:1 ENST00000333360 7 3d SELE S147 147 740 1g1t_A(0.0752) Cluster-exclusive F:2 0.0752 2 2 skcm:1|kirc:1 ENST00000333360 7 3d SELE G152 152 740 1g1t_A(0.0752) Cluster-exclusive C:1|S:1 0.0752 2 2 stad:1|hnsc:1 ENST00000333360 7 3d SELE C163 163 740 1g1t_A(0.0752) Cluster-exclusive S:1 0.0752 1 1 luad:1 ENST00000333360 7 3d FDX1 E133 133 741 3p1m_A(0.0772);3p1m_C(0.0803);3p1m_B(0.0834);3p1m_E(0.0804);3p1m_D(0.0823);3p1m_G(0.0752);3p1m_F(0.0752);3p1m_H(0.0817) Cluster-exclusive D:1 0.0752 1 1 luad:1 ENST00000260270 2 3d FDX1 M137 137 741 3p1m_A(0.0772);3p1m_C(0.0803);3p1m_B(0.0834);3p1m_E(0.0804);3p1m_D(0.0823);3p1m_G(0.0752);3p1m_F(0.0752);3p1m_H(0.0817) Cluster-exclusive I:1 0.0752 1 1 coadread:1 ENST00000260270 2 3d FDX1 D139 139 741 3p1m_A(0.0772);3p1m_C(0.0803);3p1m_B(0.0834);3p1m_E(0.0804);3p1m_D(0.0823);3p1m_G(0.0752);3p1m_F(0.0752);3p1m_H(0.0817) Cluster-exclusive N:1 0.0752 1 1 ucs:1 ENST00000260270 2 3d FDX1 L140 140 741 3p1m_A(0.0772);3p1m_C(0.0803);3p1m_B(0.0834);3p1m_E(0.0804);3p1m_D(0.0823);3p1m_G(0.0752);3p1m_F(0.0752);3p1m_H(0.0817) Cluster-exclusive V:1 0.0752 1 1 luad:1 ENST00000260270 2 3d FDX1 A141 141 741 3p1m_A(0.0772);3p1m_C(0.0803);3p1m_B(0.0834);3p1m_E(0.0804);3p1m_D(0.0823);3p1m_G(0.0752);3p1m_F(0.0752);3p1m_H(0.0817) Cluster-exclusive T:1 0.0752 1 1 luad:1 ENST00000260270 2 3d ACE P485 485 742 4bzs_B(0.0857);2xyd_B(0.0791);2c6n_B(0.0771);4bzs_A(0.0776);2c6n_A(0.0782);2xyd_A(0.0834);4bxk_A(0.0754);3nxq_B(0.0789);4ca6_A(0.084);3nxq_A(0.0831);2c6f_B(0.0794);4ca6_B(0.0845);2c6f_A(0.0818);4bxk_B(0.0764) Cluster-exclusive S:1 0.0754 1 1 skcm:1 ENST00000290866 4 3d ACE R487 487 742 4bzs_B(0.0857);2xyd_B(0.0791);2c6n_B(0.0771);4bzs_A(0.0776);2c6n_A(0.0782);2xyd_A(0.0834);4bxk_A(0.0754);3nxq_B(0.0789);4ca6_A(0.084);3nxq_A(0.0831);2c6f_B(0.0794);4ca6_B(0.0845);2c6f_A(0.0818);4bxk_B(0.0764) Cluster-exclusive H:2 0.0754 2 2 esca:1|gbm:1 ENST00000290866 4 3d ACE R508 508 742 4bzs_B(0.0857);2xyd_B(0.0791);2c6n_B(0.0771);4bzs_A(0.0776);2c6n_A(0.0782);2xyd_A(0.0834);4bxk_A(0.0754);3nxq_B(0.0789);4ca6_A(0.084);3nxq_A(0.0831);2c6f_B(0.0794);4ca6_B(0.0845);2c6f_A(0.0818);4bxk_B(0.0764) Cluster-exclusive Q:3 0.0754 3 2 ov:1|ucec:2 ENST00000290866 4 3d ACE E510 510 742 4bzs_B(0.0857);2xyd_B(0.0791);2c6n_B(0.0771);4bzs_A(0.0776);2c6n_A(0.0782);2xyd_A(0.0834);4bxk_A(0.0754);3nxq_B(0.0789);4ca6_A(0.084);3nxq_A(0.0831);2c6f_B(0.0794);4ca6_B(0.0845);2c6f_A(0.0818);4bxk_B(0.0764) Cluster-exclusive K:3 0.0754 3 3 skcm:1|ucec:1|cscc:1 ENST00000290866 4 3d PIK3CA E545 545 744 3zim_A(0.0803);4tuu_A(0.0808);4tv3_A(0.0759) Hotspot Q:6|A:9|D:3|G:8|K:251 0.0759 277 24 brca:78|npc:1|paad:1|coadread:37|esca:5|ucs:5|blca:23|hnsc:31|ov:1|gbc:2|hgg:2|lihc:1|lusc:10|lgg:3|kirp:1|lusm:1|prad:3|stad:12|gbm:5|skcm:3|ucec:14|cesc:26|kirc:3|luad:9 ENST00000263967 3 3d PIK3CA Q546 546 744 3zim_A(0.0803);4tuu_A(0.0808);4tv3_A(0.0759) Hotspot P:7|R:19|E:2|H:1|K:15|L:1 0.0759 45 12 brca:13|coadread:6|prad:2|stad:2|gbm:1|ucs:1|blca:2|hnsc:2|mbl:1|ucec:11|cesc:1|lgg:3 ENST00000263967 3 3d PIK3CA E547 547 744 3zim_A(0.0803);4tuu_A(0.0808);4tv3_A(0.0759) Hotspot-linked D:1|K:1 0.0759 2 2 stad:1|lusc:1 ENST00000263967 3 3d POTEF V839 839 745 3j0s_A(0.0759) Cluster-exclusive L:1 0.0759 1 1 luad:1 ENST00000357462 5 3d POTEF S841 841 745 3j0s_A(0.0759) Cluster-exclusive Y:1 0.0759 1 1 luad:1 ENST00000357462 5 3d POTEF L842 842 745 3j0s_A(0.0759) Cluster-exclusive Q:1 0.0759 1 1 luad:1 ENST00000357462 5 3d POTEF G846 846 745 3j0s_A(0.0759) Cluster-exclusive C:1 0.0759 1 1 luad:1 ENST00000357462 5 3d POTEF R847 847 745 3j0s_A(0.0759) Cluster-exclusive S:1 0.0759 1 1 luad:1 ENST00000357462 5 3d POTEF T849 849 745 3j0s_A(0.0759) Cluster-exclusive A:1 0.0759 1 1 prad:1 ENST00000357462 5 3d POTEF V852 852 745 3j0s_A(0.0759) Cluster-exclusive M:1 0.0759 1 1 esca:1 ENST00000357462 5 3d APCS Y71 71 746 3d5o_B(0.0759);3d5o_C(0.0912);3d5o_A(0.0838);3d5o_D(0.0772);3d5o_E(0.0851);2a3w_F(0.0944);2a3y_E(0.0981);2a3y_C(0.0988);2a3w_E(0.0948);2a3w_I(0.0965);2a3w_N(0.0982);4avs_C(0.0898);2w08_C(0.0993);2w08_B(0.0984);4avs_D(0.093);2w08_E(0.0977);4avs_A(0.099);2a3w_Q(0.098);1gyk_B(0.0939);1gyk_A(0.0911);1gyk_D(0.0916);1gyk_C(0.099);1gyk_E(0.0882);2w08_A(0.0996);4avs_E(0.0937);4ayu_A(0.0989);4ayu_E(0.0927);4ayu_D(0.0896);4ayu_C(0.0939);4ayu_B(0.0885);2a3x_A(0.0883);2a3x_B(0.0904);1sac_E(0.0912);1sac_D(0.0903);1sac_C(0.0974);2a3x_E(0.096);1sac_A(0.0917);2a3x_F(0.0931);2a3x_C(0.099);2a3x_D(0.0979);2a3x_I(0.0957);2a3x_J(0.0945);2a3x_G(0.0897);2a3x_H(0.0946);4avt_B(0.0965);4avv_A(0.0958);4avt_C(0.0996);4avt_A(0.0924);1lgn_E(0.0894);1lgn_D(0.096);4avv_D(0.0965);4avt_F(0.0996);4avv_E(0.0974);4avt_G(0.0956);1lgn_C(0.0904);4avv_B(0.0924);4avt_D(0.0866);1lgn_B(0.0908);1lgn_A(0.0902);4avv_C(0.0979);4avt_E(0.0917);4avt_J(0.1);4avt_H(0.098);4avt_I(0.0977) Cluster-exclusive C:1 0.0759 1 1 ucec:1 ENST00000255040 2 3d APCS E79 79 746 3d5o_B(0.0759);3d5o_C(0.0912);3d5o_A(0.0838);3d5o_D(0.0772);3d5o_E(0.0851);2a3w_F(0.0944);2a3y_E(0.0981);2a3y_C(0.0988);2a3w_E(0.0948);2a3w_I(0.0965);2a3w_N(0.0982);4avs_C(0.0898);2w08_C(0.0993);2w08_B(0.0984);4avs_D(0.093);2w08_E(0.0977);4avs_A(0.099);2a3w_Q(0.098);1gyk_B(0.0939);1gyk_A(0.0911);1gyk_D(0.0916);1gyk_C(0.099);1gyk_E(0.0882);2w08_A(0.0996);4avs_E(0.0937);4ayu_A(0.0989);4ayu_E(0.0927);4ayu_D(0.0896);4ayu_C(0.0939);4ayu_B(0.0885);2a3x_A(0.0883);2a3x_B(0.0904);1sac_E(0.0912);1sac_D(0.0903);1sac_C(0.0974);2a3x_E(0.096);1sac_A(0.0917);2a3x_F(0.0931);2a3x_C(0.099);2a3x_D(0.0979);2a3x_I(0.0957);2a3x_J(0.0945);2a3x_G(0.0897);2a3x_H(0.0946);4avt_B(0.0965);4avv_A(0.0958);4avt_C(0.0996);4avt_A(0.0924);1lgn_E(0.0894);1lgn_D(0.096);4avv_D(0.0965);4avt_F(0.0996);4avv_E(0.0974);4avt_G(0.0956);1lgn_C(0.0904);4avv_B(0.0924);4avt_D(0.0866);1lgn_B(0.0908);1lgn_A(0.0902);4avv_C(0.0979);4avt_E(0.0917);4avt_J(0.1);4avt_H(0.098);4avt_I(0.0977) Cluster-exclusive K:1 0.0759 1 1 cscc:1 ENST00000255040 2 3d APCS Y93 93 746 3d5o_B(0.0759);3d5o_C(0.0912);3d5o_A(0.0838);3d5o_D(0.0772);3d5o_E(0.0851);2a3w_F(0.0944);2a3y_E(0.0981);2a3y_C(0.0988);2a3w_E(0.0948);2a3w_I(0.0965);2a3w_N(0.0982);4avs_C(0.0898);2w08_C(0.0993);2w08_B(0.0984);4avs_D(0.093);2w08_E(0.0977);4avs_A(0.099);2a3w_Q(0.098);1gyk_B(0.0939);1gyk_A(0.0911);1gyk_D(0.0916);1gyk_C(0.099);1gyk_E(0.0882);2w08_A(0.0996);4avs_E(0.0937);4ayu_A(0.0989);4ayu_E(0.0927);4ayu_D(0.0896);4ayu_C(0.0939);4ayu_B(0.0885);2a3x_A(0.0883);2a3x_B(0.0904);1sac_E(0.0912);1sac_D(0.0903);1sac_C(0.0974);2a3x_E(0.096);1sac_A(0.0917);2a3x_F(0.0931);2a3x_C(0.099);2a3x_D(0.0979);2a3x_I(0.0957);2a3x_J(0.0945);2a3x_G(0.0897);2a3x_H(0.0946);4avt_B(0.0965);4avv_A(0.0958);4avt_C(0.0996);4avt_A(0.0924);1lgn_E(0.0894);1lgn_D(0.096);4avv_D(0.0965);4avt_F(0.0996);4avv_E(0.0974);4avt_G(0.0956);1lgn_C(0.0904);4avv_B(0.0924);4avt_D(0.0866);1lgn_B(0.0908);1lgn_A(0.0902);4avv_C(0.0979);4avt_E(0.0917);4avt_J(0.1);4avt_H(0.098);4avt_I(0.0977) Cluster-exclusive H:1 0.0759 1 1 lihc:1 ENST00000255040 2 3d APCS G95 95 746 3d5o_B(0.0759);3d5o_C(0.0912);3d5o_A(0.0838);3d5o_D(0.0772);3d5o_E(0.0851);2a3w_F(0.0944);2a3y_E(0.0981);2a3y_C(0.0988);2a3w_E(0.0948);2a3w_I(0.0965);2a3w_N(0.0982);4avs_C(0.0898);2w08_C(0.0993);2w08_B(0.0984);4avs_D(0.093);2w08_E(0.0977);4avs_A(0.099);2a3w_Q(0.098);1gyk_B(0.0939);1gyk_A(0.0911);1gyk_D(0.0916);1gyk_C(0.099);1gyk_E(0.0882);2w08_A(0.0996);4avs_E(0.0937);4ayu_A(0.0989);4ayu_E(0.0927);4ayu_D(0.0896);4ayu_C(0.0939);4ayu_B(0.0885);2a3x_A(0.0883);2a3x_B(0.0904);1sac_E(0.0912);1sac_D(0.0903);1sac_C(0.0974);2a3x_E(0.096);1sac_A(0.0917);2a3x_F(0.0931);2a3x_C(0.099);2a3x_D(0.0979);2a3x_I(0.0957);2a3x_J(0.0945);2a3x_G(0.0897);2a3x_H(0.0946);4avt_B(0.0965);4avv_A(0.0958);4avt_C(0.0996);4avt_A(0.0924);1lgn_E(0.0894);1lgn_D(0.096);4avv_D(0.0965);4avt_F(0.0996);4avv_E(0.0974);4avt_G(0.0956);1lgn_C(0.0904);4avv_B(0.0924);4avt_D(0.0866);1lgn_B(0.0908);1lgn_A(0.0902);4avv_C(0.0979);4avt_E(0.0917);4avt_J(0.1);4avt_H(0.098);4avt_I(0.0977) Cluster-exclusive R:1 0.0759 1 1 cscc:1 ENST00000255040 2 3d APCS E145 145 746 3d5o_B(0.0759);3d5o_C(0.0912);3d5o_A(0.0838);3d5o_D(0.0772);3d5o_E(0.0851);2a3w_F(0.0944);2a3y_E(0.0981);2a3y_C(0.0988);2a3w_E(0.0948);2a3w_I(0.0965);2a3w_N(0.0982);4avs_C(0.0898);2w08_C(0.0993);2w08_B(0.0984);4avs_D(0.093);2w08_E(0.0977);4avs_A(0.099);2a3w_Q(0.098);1gyk_B(0.0939);1gyk_A(0.0911);1gyk_D(0.0916);1gyk_C(0.099);1gyk_E(0.0882);2w08_A(0.0996);4avs_E(0.0937);4ayu_A(0.0989);4ayu_E(0.0927);4ayu_D(0.0896);4ayu_C(0.0939);4ayu_B(0.0885);2a3x_A(0.0883);2a3x_B(0.0904);1sac_E(0.0912);1sac_D(0.0903);1sac_C(0.0974);2a3x_E(0.096);1sac_A(0.0917);2a3x_F(0.0931);2a3x_C(0.099);2a3x_D(0.0979);2a3x_I(0.0957);2a3x_J(0.0945);2a3x_G(0.0897);2a3x_H(0.0946);4avt_B(0.0965);4avv_A(0.0958);4avt_C(0.0996);4avt_A(0.0924);1lgn_E(0.0894);1lgn_D(0.096);4avv_D(0.0965);4avt_F(0.0996);4avv_E(0.0974);4avt_G(0.0956);1lgn_C(0.0904);4avv_B(0.0924);4avt_D(0.0866);1lgn_B(0.0908);1lgn_A(0.0902);4avv_C(0.0979);4avt_E(0.0917);4avt_J(0.1);4avt_H(0.098);4avt_I(0.0977) Cluster-exclusive G:1 0.0759 1 1 lihc:1 ENST00000255040 2 3d COL22A1 G1171 1171 747 3fby_A(0.076) Cluster-exclusive R:1|E:1 0.076 2 2 stad:1|skcm:1 ENST00000303045 6 3d COL22A1 R1173 1173 747 3fby_A(0.076) Cluster-exclusive C:1 0.076 1 1 ucec:1 ENST00000303045 6 3d COL22A1 G1174 1174 747 3fby_A(0.076) Cluster-exclusive C:1 0.076 1 1 gbm:1 ENST00000303045 6 3d COL22A1 A1175 1175 747 3fby_A(0.076) Cluster-exclusive T:1 0.076 1 1 hnsc:1 ENST00000303045 6 3d COL22A1 D1176 1176 747 3fby_A(0.076) Cluster-exclusive H:1 0.076 1 1 luad:1 ENST00000303045 6 3d COL22A1 V1179 1179 747 3fby_A(0.076) Cluster-exclusive I:2 0.076 2 2 cll:1|esca:1 ENST00000303045 6 3d COL22A1 D1184 1184 747 3fby_A(0.076) Cluster-exclusive G:1 0.076 1 1 blca:1 ENST00000303045 6 3d MRPL11 A121 121 748 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive S:1 0.0764 1 1 skcm:1 ENST00000310999 7 3d MRPL11 R122 122 748 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive H:1 0.0764 1 1 luad:1 ENST00000310999 7 3d MRPL11 V141 141 748 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive L:1 0.0764 1 1 lihc:1 ENST00000310999 7 3d MRPL11 V140 140 749 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive A:1 0.0764 1 1 gbm:1 ENST00000310999 7 3d CST6 P7 7 751 1g0y_R(0.0766);4dep_E(0.085) Cluster-exclusive Q:1 0.0766 1 1 kirp:1 ENST00000312134 2 3d CST6 T72 72 751 1g0y_R(0.0766);4dep_E(0.085) Cluster-exclusive M:1 0.0766 1 1 lihc:1 ENST00000312134 2 3d CST6 T90 90 751 1g0y_R(0.0766);4dep_E(0.085) Cluster-exclusive K:1|M:1 0.0766 2 2 coadread:1|lihc:1 ENST00000312134 2 3d CST6 M91 91 751 1g0y_R(0.0766);4dep_E(0.085) Cluster-exclusive I:1 0.0766 1 1 skcm:1 ENST00000312134 2 3d CST6 S4 4 752 1g0y_R(0.0766);4dep_B(0.0816);1ira_Y(0.0779);4dep_E(0.085);4gaf_B(0.0846) Cluster-exclusive W:1 0.0766 1 1 lusc:1 ENST00000312134 2 3d MYOM1 R711 711 753 1eqf_A(0.0766) Cluster-exclusive H:1 0.0766 1 1 stad:1 ENST00000356443 4 3d MYOM1 R713 713 753 1eqf_A(0.0766) Cluster-exclusive C:1|L:1 0.0766 2 2 coadread:1|hnsc:1 ENST00000356443 4 3d MYOM1 S715 715 753 1eqf_A(0.0766) Cluster-exclusive A:1 0.0766 1 1 nbl:1 ENST00000356443 4 3d DOCK8 E1973 1973 754 3vhl_A(0.0767) Cluster-exclusive D:1|K:1 0.0767 2 2 skcm:1|nbl:1 ENST00000432829 2 3d DOCK8 E1977 1977 754 3vhl_A(0.0767) Cluster-exclusive K:1 0.0767 1 1 skcm:1 ENST00000432829 2 3d DOCK8 L1978 1978 754 3vhl_A(0.0767) Cluster-exclusive H:1 0.0767 1 1 ov:1 ENST00000432829 2 3d DOCK8 K1980 1980 754 3vhl_A(0.0767) Cluster-exclusive N:1 0.0767 1 1 ucec:1 ENST00000432829 2 3d DOCK8 N1981 1981 754 3vhl_A(0.0767) Cluster-exclusive S:1 0.0767 1 1 ucec:1 ENST00000432829 2 3d CDKN2C A77 77 755 1bu9_A(0.0769) Cluster-exclusive V:1 0.0769 1 1 coadread:1 ENST00000262662 1 3d ABCB6 R634 634 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive C:2|H:1 0.077 3 3 lusm:1|ucs:1|ucec:1 ENST00000265316 3 3d ABCB6 L636 636 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive V:1 0.077 1 1 luad:1 ENST00000265316 3 3d ABCB6 R638 638 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive C:1 0.077 1 1 gbm:1 ENST00000265316 3 3d ABCB6 I654 654 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive V:1 0.077 1 1 luad:1 ENST00000265316 3 3d ABCB6 L662 662 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive P:1 0.077 1 1 kirp:1 ENST00000265316 3 3d ABCB6 R663 663 756 3nhb_A(0.0817);3nha_A(0.0812);3nh9_A(0.0861);3nh6_A(0.077) Cluster-exclusive W:1 0.077 1 1 skcm:1 ENST00000265316 3 3d RABGAP1L R584 584 757 3hzj_C(0.0774);3hzj_B(0.0804);3hzj_A(0.0786) Cluster-exclusive C:3 0.0774 3 1 skcm:3 ENST00000251507 4 3d RABGAP1L P587 587 757 3hzj_C(0.0774);3hzj_B(0.0804);3hzj_A(0.0786) Cluster-exclusive S:1 0.0774 1 1 skcm:1 ENST00000251507 4 3d RABGAP1L A588 588 757 3hzj_C(0.0774);3hzj_B(0.0804);3hzj_A(0.0786) Cluster-exclusive T:3 0.0774 3 3 paad:1|coadread:1|prad:1 ENST00000251507 4 3d RABGAP1L H589 589 757 3hzj_C(0.0774);3hzj_B(0.0804);3hzj_A(0.0786) Cluster-exclusive Y:1 0.0774 1 1 coadread:1 ENST00000251507 4 3d KIFC1 R655 655 758 2rep_A(0.0775) Cluster-exclusive H:1|L:1 0.0775 2 2 brca:1|luad:1 ENST00000374523 4 3d KIFC1 A657 657 758 2rep_A(0.0775) Cluster-exclusive T:1 0.0775 1 1 ucec:1 ENST00000374523 4 3d KIFC1 S658 658 758 2rep_A(0.0775) Cluster-exclusive F:1 0.0775 1 1 brca:1 ENST00000374523 4 3d KIFC1 K659 659 758 2rep_A(0.0775) Cluster-exclusive R:1 0.0775 1 1 lihc:1 ENST00000374523 4 3d THRB E217 217 759 3gws_X(0.0857);3imy_A(0.0904);3jzc_A(0.078) Cluster-exclusive K:2 0.078 2 1 skcm:2 ENST00000356447 4 3d THRB E218 218 759 3gws_X(0.0857);3imy_A(0.0904);3jzc_A(0.078) Cluster-exclusive G:1 0.078 1 1 stad:1 ENST00000356447 4 3d THRB E220 220 759 3gws_X(0.0857);3imy_A(0.0904);3jzc_A(0.078) Cluster-exclusive K:1 0.078 1 1 skcm:1 ENST00000356447 4 3d THRB I222 222 759 3gws_X(0.0857);3imy_A(0.0904);3jzc_A(0.078) Cluster-exclusive V:1|M:1 0.078 2 2 coadread:1|cscc:1 ENST00000356447 4 3d CSF3 E126 126 760 2d9q_A(0.078);1pgr_A(0.0941);1cd9_C(0.093);1cd9_A(0.0992) Cluster-exclusive K:1 0.078 1 1 cscc:1 ENST00000225474 2 3d CSF3 S175 175 760 2d9q_A(0.078);1pgr_A(0.0941);1cd9_C(0.093);1cd9_A(0.0992) Cluster-exclusive F:1 0.078 1 1 skcm:1 ENST00000225474 2 3d CSF3 R179 179 760 2d9q_A(0.078);1pgr_A(0.0941);1cd9_C(0.093);1cd9_A(0.0992) Cluster-exclusive H:1 0.078 1 1 stad:1 ENST00000225474 2 3d CSF3 A181 181 760 2d9q_A(0.078);1pgr_A(0.0941);1cd9_C(0.093);1cd9_A(0.0992) Cluster-exclusive E:1 0.078 1 1 stad:1 ENST00000225474 2 3d CSF3 G182 182 760 2d9q_A(0.078);1pgr_A(0.0941);1cd9_C(0.093);1cd9_A(0.0992) Cluster-exclusive Q:1 0.078 1 1 cscc:1 ENST00000225474 2 3d EEF1A1 R427 427 762 1ijf_A(0.0825);1ije_A(0.0796);1f60_A(0.0846);1g7c_A(0.0786);2b7b_A(0.0837);2b7c_A(0.08) Cluster-exclusive C:1 0.0786 1 1 skcm:1 ENST00000309268 6 3d EEF1A1 T432 432 762 1ijf_A(0.0825);1ije_A(0.0796);1f60_A(0.0846);1g7c_A(0.0786);2b7b_A(0.0837);2b7c_A(0.08) Cluster-exclusive A:1|S:3|I:4|L:3 0.0786 11 3 gbm:1|hnsc:2|lihc:8 ENST00000309268 6 3d EEF1A1 V433 433 762 1ijf_A(0.0825);1ije_A(0.0796);1f60_A(0.0846);1g7c_A(0.0786);2b7b_A(0.0837);2b7c_A(0.08) Cluster-exclusive L:1 0.0786 1 1 luad:1 ENST00000309268 6 3d TRAP1 T333 333 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive M:1 0.0786 1 1 ucec:1 ENST00000246957 5 3d TRAP1 D334 334 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive N:1 0.0786 1 1 skcm:1 ENST00000246957 5 3d TRAP1 I339 339 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive N:1 0.0786 1 1 stad:1 ENST00000246957 5 3d TRAP1 R340 340 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive C:1 0.0786 1 1 stad:1 ENST00000246957 5 3d TRAP1 S341 341 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive C:1 0.0786 1 1 lusm:1 ENST00000246957 5 3d TRAP1 I342 342 763 4z1i_D(0.0786);4z1i_B(0.0909);4z1i_A(0.0832) Cluster-exclusive M:1 0.0786 1 1 luad:1 ENST00000246957 5 3d CLASP1 D404 404 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive N:1 0.0786 1 1 lihc:1 ENST00000263710 4 3d CLASP1 A407 407 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive T:1 0.0786 1 1 coadread:1 ENST00000263710 4 3d CLASP1 E408 408 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive K:1 0.0786 1 1 ov:1 ENST00000263710 4 3d CLASP1 L445 445 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive S:1 0.0786 1 1 skcm:1 ENST00000263710 4 3d CLASP1 P447 447 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive H:1 0.0786 1 1 ucec:1 ENST00000263710 4 3d CLASP1 I449 449 764 4k92_A(0.0805);4k92_B(0.0786) Cluster-exclusive V:1 0.0786 1 1 stad:1 ENST00000263710 4 3d RXRA R421 421 765 3nsp_B(0.098);1uhl_A(0.0787);1xdk_A(0.0969) Hotspot-linked C:1|H:1 0.0787 2 2 esca:1|hnsc:1 ENST00000481739 1 3d DLX5 E166 166 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive Q:1 0.0787 1 1 kirp:1 ENST00000222598 4 3d DLX5 R167 167 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive C:1 0.0787 1 1 brca:1 ENST00000222598 4 3d DLX5 E169 169 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive K:1 0.0787 1 1 stad:1 ENST00000222598 4 3d DLX5 A171 171 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive T:1 0.0787 1 1 hnsc:1 ENST00000222598 4 3d DLX5 A172 172 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive T:1 0.0787 1 1 stad:1 ENST00000222598 4 3d DLX5 S173 173 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive L:1 0.0787 1 1 skcm:1 ENST00000222598 4 3d DLX5 G175 175 766 4rdu_A(0.0811);4rdu_D(0.0787) Cluster-exclusive E:1 0.0787 1 1 skcm:1 ENST00000222598 4 3d CTSL R153 153 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive W:2 0.0789 2 2 coadread:1|stad:1 ENST00000340342 6 3d CTSL T332 332 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive S:1 0.0789 1 1 acc:1 ENST00000340342 6 3d CBL I393 393 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive T:1 0.0789 1 1 paad:1 ENST00000264033 4 3d CBL W408 408 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive L:1 0.0789 1 1 mds:1 ENST00000264033 4 3d CBL G415 415 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive S:1 0.0789 1 1 luad:1 ENST00000264033 4 3d CBL C416 416 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive S:1 0.0789 1 1 skcm:1 ENST00000264033 4 3d CBL P417 417 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive H:1|L:1 0.0789 2 1 skcm:2 ENST00000264033 4 3d CBL F418 418 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive I:1 0.0789 1 1 skcm:1 ENST00000264033 4 3d CBL R420 420 768 1fbv_A(0.0796);4a4b_A(0.0809);4a4c_A(0.0791);2y1m_C(0.0804);2y1m_B(0.079);2y1n_A(0.0918);3zni_A(0.0867);2y1m_A(0.0807);2y1m_F(0.0834);2y1m_E(0.0789);2y1m_D(0.0814);2y1n_C(0.0939);3zni_I(0.087) Cluster-exclusive G:1 0.0789 1 1 skcm:1 ENST00000264033 4 3d SLC25A4 G115 115 770 1okc_A(0.0877);2c3e_A(0.0795) Cluster-exclusive D:1 0.0795 1 1 coadread:1 ENST00000281456 6 3d SLC25A4 G120 120 770 1okc_A(0.0877);2c3e_A(0.0795) Cluster-exclusive S:1 0.0795 1 1 ucec:1 ENST00000281456 6 3d SLC25A4 A122 122 770 1okc_A(0.0877);2c3e_A(0.0795) Cluster-exclusive V:1 0.0795 1 1 luad:1 ENST00000281456 6 3d SLC25A4 A123 123 770 1okc_A(0.0877);2c3e_A(0.0795) Cluster-exclusive T:1 0.0795 1 1 brca:1 ENST00000281456 6 3d SLC25A4 R188 188 770 1okc_A(0.0877);2c3e_A(0.0795) Cluster-exclusive K:1 0.0795 1 1 ov:1 ENST00000281456 6 3d STK24 P92 92 771 3ckx_A(0.0796) Cluster-exclusive S:1 0.0796 1 1 skcm:1 ENST00000376547 3 3d STK24 S165 165 771 3ckx_A(0.0796) Cluster-exclusive P:1 0.0796 1 1 coadread:1 ENST00000376547 3 3d STK24 G168 168 771 3ckx_A(0.0796) Cluster-exclusive D:1 0.0796 1 1 luad:1 ENST00000376547 3 3d STK24 E169 169 771 3ckx_A(0.0796) Cluster-exclusive 0.0796 1 ENST00000376547 3 3d SDR39U1 D53 53 772 4b4o_A(0.089);4b4o_D(0.0913);4b4o_E(0.091);4b4o_B(0.0897);4b4o_C(0.0796);4b4o_H(0.0864);4b4o_F(0.0824);4b4o_G(0.0894) Cluster-exclusive G:1 0.0796 1 1 mbl:1 ENST00000399390 1 3d SDR39U1 S54 54 772 4b4o_A(0.089);4b4o_D(0.0913);4b4o_E(0.091);4b4o_B(0.0897);4b4o_C(0.0796);4b4o_H(0.0864);4b4o_F(0.0824);4b4o_G(0.0894) Cluster-exclusive F:1 0.0796 1 1 gbm:1 ENST00000399390 1 3d SDR39U1 T55 55 772 4b4o_A(0.089);4b4o_D(0.0913);4b4o_E(0.091);4b4o_B(0.0897);4b4o_C(0.0796);4b4o_H(0.0864);4b4o_F(0.0824);4b4o_G(0.0894) Cluster-exclusive A:1 0.0796 1 1 stad:1 ENST00000399390 1 3d SDR39U1 G63 63 772 4b4o_A(0.089);4b4o_D(0.0913);4b4o_E(0.091);4b4o_B(0.0897);4b4o_C(0.0796);4b4o_H(0.0864);4b4o_F(0.0824);4b4o_G(0.0894) Cluster-exclusive W:1 0.0796 1 1 stad:1 ENST00000399390 1 3d LGALS1 E87 87 773 3oyw_A(0.081);3w59_C(0.0964);1w6n_A(0.0942);2zkn_B(0.0812);1w6o_A(0.0977);3oy8_A(0.0946);2zkn_A(0.0798);1w6p_A(0.0974);1gzw_A(0.0998) Cluster-exclusive Q:1 0.0798 1 1 brca:1 ENST00000215909 5 3d LGALS1 V99 99 773 3oyw_A(0.081);3w59_C(0.0964);1w6n_A(0.0942);2zkn_B(0.0812);1w6o_A(0.0977);3oy8_A(0.0946);2zkn_A(0.0798);1w6p_A(0.0974);1gzw_A(0.0998) Cluster-exclusive I:1 0.0798 1 1 paad:1 ENST00000215909 5 3d LGALS1 K100 100 773 3oyw_A(0.081);3w59_C(0.0964);1w6n_A(0.0942);2zkn_B(0.0812);1w6o_A(0.0977);3oy8_A(0.0946);2zkn_A(0.0798);1w6p_A(0.0974);1gzw_A(0.0998) Cluster-exclusive R:1 0.0798 1 1 lusc:1 ENST00000215909 5 3d LGALS1 G104 104 773 3oyw_A(0.081);3w59_C(0.0964);1w6n_A(0.0942);2zkn_B(0.0812);1w6o_A(0.0977);3oy8_A(0.0946);2zkn_A(0.0798);1w6p_A(0.0974);1gzw_A(0.0998) Cluster-exclusive V:1 0.0798 1 1 hnsc:1 ENST00000215909 5 3d LGALS1 E106 106 773 3oyw_A(0.081);3w59_C(0.0964);1w6n_A(0.0942);2zkn_B(0.0812);1w6o_A(0.0977);3oy8_A(0.0946);2zkn_A(0.0798);1w6p_A(0.0974);1gzw_A(0.0998) Cluster-exclusive K:2 0.0798 2 2 coadread:1|gbm:1 ENST00000215909 5 3d BCOR P1648 1648 774 4hpl_A(0.0801) Cluster-exclusive Q:1|L:1 0.0801 2 2 skcm:1|lihc:1 ENST00000378444 4 3d BCOR C1649 1649 774 4hpl_A(0.0801) Cluster-exclusive S:1 0.0801 1 1 coadread:1 ENST00000378444 4 3d BCOR W1663 1663 774 4hpl_A(0.0801) Cluster-exclusive L:1 0.0801 1 1 skcm:1 ENST00000378444 4 3d BCOR L1665 1665 774 4hpl_A(0.0801) Cluster-exclusive M:1 0.0801 1 1 gbm:1 ENST00000378444 4 3d INPP4A V821 821 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive F:1 0.0803 1 1 luad:1 ENST00000074304 5 3d INPP4A E825 825 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive A:1 0.0803 1 1 lusm:1 ENST00000074304 5 3d INPP4A R829 829 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive Q:1|W:1 0.0803 2 2 coadread:1|ucec:1 ENST00000074304 5 3d INPP4A N831 831 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive H:1 0.0803 1 1 coadread:1 ENST00000074304 5 3d INPP4A S832 832 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive F:1 0.0803 1 1 cscc:1 ENST00000074304 5 3d INPP4A Q864 864 775 2iwi_A(0.0843);2iwi_B(0.0803) Cluster-exclusive H:1 0.0803 1 1 brca:1 ENST00000074304 5 3d RHCG A163 163 777 3hd6_A(0.0805) Cluster-exclusive T:1 0.0805 1 1 esca:1 ENST00000268122 4 3d RHCG V164 164 777 3hd6_A(0.0805) Cluster-exclusive M:1 0.0805 1 1 ucs:1 ENST00000268122 4 3d RHCG N165 165 777 3hd6_A(0.0805) Cluster-exclusive D:1 0.0805 1 1 kirp:1 ENST00000268122 4 3d RHCG F167 167 777 3hd6_A(0.0805) Cluster-exclusive S:1 0.0805 1 1 stad:1 ENST00000268122 4 3d RHCG M182 182 777 3hd6_A(0.0805) Cluster-exclusive I:1 0.0805 1 1 skcm:1 ENST00000268122 4 3d RHCG V400 400 777 3hd6_A(0.0805) Cluster-exclusive M:1 0.0805 1 1 lihc:1 ENST00000268122 4 3d RHCG T401 401 777 3hd6_A(0.0805) Cluster-exclusive A:1 0.0805 1 1 coadread:1 ENST00000268122 4 3d KCNH5 H54 54 780 3gqc_D(0.0807);3gqc_B(0.0941) Cluster-exclusive Q:1 0.0807 1 1 esca:1 ENST00000322893 7 3d KCNH5 R55 55 780 3gqc_D(0.0807);3gqc_B(0.0941) Cluster-exclusive Q:1 0.0807 1 1 cscc:1 ENST00000322893 7 3d KCNH5 A56 56 780 3gqc_D(0.0807);3gqc_B(0.0941) Cluster-exclusive S:1|T:1 0.0807 2 2 stad:1|lusc:1 ENST00000322893 7 3d KCNH5 V58 58 780 3gqc_D(0.0807);3gqc_B(0.0941) Cluster-exclusive I:1 0.0807 1 1 stad:1 ENST00000322893 7 3d KCNH5 T64 64 780 3gqc_D(0.0807);3gqc_B(0.0941) Cluster-exclusive S:1 0.0807 1 1 lusc:1 ENST00000322893 7 3d PCDH15 D47 47 782 4aqe_B(0.0858);4axw_B(0.0819);4aqa_B(0.0898);4aq8_D(0.0871);4aq8_C(0.0949);4apx_B(0.081) Cluster-exclusive Y:1|N:1 0.081 2 2 ucec:1|luad:1 ENST00000320301 6 3d PCDH15 W84 84 782 4aqe_B(0.0858);4axw_B(0.0819);4aqa_B(0.0898);4aq8_D(0.0871);4aq8_C(0.0949);4apx_B(0.081) Cluster-exclusive R:1 0.081 1 1 luad:1 ENST00000320301 6 3d PCDH15 L103 103 782 4aqe_B(0.0858);4axw_B(0.0819);4aqa_B(0.0898);4aq8_D(0.0871);4aq8_C(0.0949);4apx_B(0.081) Cluster-exclusive P:1 0.081 1 1 luad:1 ENST00000320301 6 3d PCDH15 D104 104 782 4aqe_B(0.0858);4axw_B(0.0819);4aqa_B(0.0898);4aq8_D(0.0871);4aq8_C(0.0949);4apx_B(0.081) Cluster-exclusive H:1|N:1 0.081 2 2 cscc:1|luad:1 ENST00000320301 6 3d PCDH15 R105 105 782 4aqe_B(0.0858);4axw_B(0.0819);4aqa_B(0.0898);4aq8_D(0.0871);4aq8_C(0.0949);4apx_B(0.081) Cluster-exclusive I:1 0.081 1 1 stad:1 ENST00000320301 6 3d LCMT1 L97 97 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive H:1 0.0813 1 1 coadread:1 ENST00000399069 3 3d LCMT1 G98 98 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive V:1 0.0813 1 1 luad:1 ENST00000399069 3 3d LCMT1 A99 99 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive T:1 0.0813 1 1 paad:1 ENST00000399069 3 3d LCMT1 G100 100 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive S:1 0.0813 1 1 luad:1 ENST00000399069 3 3d LCMT1 L172 172 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive F:1 0.0813 1 1 cesc:1 ENST00000399069 3 3d LCMT1 E198 198 783 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3p71_T(0.0922);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965);3iei_F(0.0937) Cluster-exclusive Q:1 0.0813 1 1 luad:1 ENST00000399069 3 3d LCMT1 L212 212 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive I:1 0.0813 1 1 skcm:1 ENST00000399069 3 3d HNRNPH2 E125 125 785 2kg0_A(0.0975);2hgm_A(0.0813) Cluster-exclusive K:1 0.0813 1 1 hnsc:1 ENST00000316594 5 3d HNRNPH2 F130 130 785 2kg0_A(0.0975);2hgm_A(0.0813) Cluster-exclusive L:2 0.0813 2 1 luad:2 ENST00000316594 5 3d HNRNPH2 S132 132 785 2kg0_A(0.0975);2hgm_A(0.0813) Cluster-exclusive L:1 0.0813 1 1 skcm:1 ENST00000316594 5 3d HNRNPH2 G133 133 785 2kg0_A(0.0975);2hgm_A(0.0813) Cluster-exclusive R:1 0.0813 1 1 ucec:1 ENST00000316594 5 3d TP53 Q136 136 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot-linked P:1|E:7|H:1 0.0814 9 6 brca:1|stad:1|gbm:1|hnsc:3|lihc:1|lgg:2 ENST00000269305 4 3d TP53 K139 139 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot-linked E:2|N:3 0.0814 5 3 blca:1|lihc:3|lymbc:1 ENST00000269305 4 3d TP53 C141 141 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot R:2|S:1|F:1|W:6|G:2|Y:10 0.0814 22 12 brca:5|mmyl:1|paad:1|coadread:3|prad:3|kich:1|hnsc:2|laml:1|ucec:1|lusc:1|lgg:2|luad:1 ENST00000269305 4 3d TP53 I195 195 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot S:2|T:25|F:11|M:2|N:5 0.0814 45 16 brca:7|paad:1|mmyl:2|coadread:4|cll:1|esca:2|ucs:1|hnsc:4|laml:1|ov:11|lihc:3|lusc:1|lgg:3|stad:1|gbm:2|luad:1 ENST00000269305 4 3d TP53 R196 196 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot P:6 0.0814 6 4 paad:1|lusm:1|esca:1|hnsc:3 ENST00000269305 4 3d TP53 Y234 234 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot C:23|S:2|D:1|H:2|N:1 0.0814 29 14 acc:1|brca:4|paad:1|coadread:1|esca:2|blca:1|hnsc:3|ov:4|lihc:2|lusc:3|lusm:1|prad:1|stad:2|gbm:3 ENST00000269305 4 3d RB1 Q444 444 789 3pom_A(0.0819);3pom_B(0.0821);1n4m_A(0.0904);1gh6_B(0.0815);4ell_A(0.0847) Cluster-exclusive H:1|L:1 0.0815 2 2 lusm:1|stad:1 ENST00000267163 4 3d RB1 G449 449 789 3pom_A(0.0819);3pom_B(0.0821);1n4m_A(0.0904);1gh6_B(0.0815);4ell_A(0.0847) Cluster-exclusive R:1|E:1|V:1 0.0815 3 3 lusm:1|skcm:1|cesc:1 ENST00000267163 4 3d RB1 R451 451 789 3pom_A(0.0819);3pom_B(0.0821);1n4m_A(0.0904);1gh6_B(0.0815);4ell_A(0.0847) Cluster-exclusive C:3|H:1 0.0815 4 3 coadread:2|ucec:1|lusc:1 ENST00000267163 4 3d RB1 L491 491 789 3pom_A(0.0819);3pom_B(0.0821);1n4m_A(0.0904);1gh6_B(0.0815);4ell_A(0.0847) Cluster-exclusive P:2 0.0815 2 2 mmyl:1|lihc:1 ENST00000267163 4 3d HASPIN A509 509 790 2wb8_A(0.0937);3e7v_A(0.0942);4qtc_A(0.0866);4ouc_A(0.0922);3dlz_A(0.0831);3fmd_A(0.0943);3iq7_A(0.0921);3f2n_A(0.0818) Cluster-exclusive V:1 0.0818 1 1 skcm:1 ENST00000325418 4 3d HASPIN G558 558 790 2wb8_A(0.0937);3e7v_A(0.0942);4qtc_A(0.0866);4ouc_A(0.0922);3dlz_A(0.0831);3fmd_A(0.0943);3iq7_A(0.0921);3f2n_A(0.0818) Cluster-exclusive R:2 0.0818 2 2 skcm:1|lihc:1 ENST00000325418 4 3d HASPIN L603 603 790 2wb8_A(0.0937);3e7v_A(0.0942);4qtc_A(0.0866);4ouc_A(0.0922);3dlz_A(0.0831);3fmd_A(0.0943);3iq7_A(0.0921);3f2n_A(0.0818) Cluster-exclusive V:1 0.0818 1 1 kirp:1 ENST00000325418 4 3d HASPIN E604 604 790 2wb8_A(0.0937);3e7v_A(0.0942);4qtc_A(0.0866);4ouc_A(0.0922);3dlz_A(0.0831);3fmd_A(0.0943);3iq7_A(0.0921);3f2n_A(0.0818) Cluster-exclusive Q:1|G:1 0.0818 2 2 hnsc:1|cesc:1 ENST00000325418 4 3d BAX A124 124 791 2k7w_A(0.0819) Cluster-exclusive V:1 0.0819 1 1 skcm:1 ENST00000345358 7 3d BAX L125 125 791 2k7w_A(0.0819) Cluster-exclusive M:2 0.0819 2 2 coadread:1|cscc:1 ENST00000345358 7 3d BAX E131 131 791 2k7w_A(0.0819) Cluster-exclusive K:1 0.0819 1 1 brca:1 ENST00000345358 7 3d BAX I133 133 791 2k7w_A(0.0819) Cluster-exclusive M:2 0.0819 2 2 coadread:1|luad:1 ENST00000345358 7 3d FGF1 L29 29 792 1z4s_A(0.0984);3fjd_B(0.0922);1jt7_C(0.0941);3fgm_B(0.0872);1jt7_D(0.0916);3fgm_A(0.0878);1m16_B(0.089);3ojm_A(0.0986);1nzk_A(0.0838);1nzk_B(0.0872);1nzk_C(0.082);1jt7_A(0.0952);1jt7_B(0.0945);1nzk_D(0.0848);1m16_A(0.0988);1ry7_A(0.0999);2uus_A(0.0971);2uus_B(0.0983) Cluster-exclusive I:1 0.082 1 1 stad:1 ENST00000337706 2 3d FGF1 N110 110 792 1z4s_A(0.0984);3fjd_B(0.0922);1jt7_C(0.0941);3fgm_B(0.0872);1jt7_D(0.0916);3fgm_A(0.0878);1m16_B(0.089);3ojm_A(0.0986);1nzk_A(0.0838);1nzk_B(0.0872);1nzk_C(0.082);1jt7_A(0.0952);1jt7_B(0.0945);1nzk_D(0.0848);1m16_A(0.0988);1ry7_A(0.0999);2uus_A(0.0971);2uus_B(0.0983) Cluster-exclusive T:1 0.082 1 1 coadread:1 ENST00000337706 2 3d FGF1 L148 148 792 1z4s_A(0.0984);3fjd_B(0.0922);1jt7_C(0.0941);3fgm_B(0.0872);1jt7_D(0.0916);3fgm_A(0.0878);1m16_B(0.089);3ojm_A(0.0986);1nzk_A(0.0838);1nzk_B(0.0872);1nzk_C(0.082);1jt7_A(0.0952);1jt7_B(0.0945);1nzk_D(0.0848);1m16_A(0.0988);1ry7_A(0.0999);2uus_A(0.0971);2uus_B(0.0983) Cluster-exclusive P:1|F:1 0.082 2 2 blca:1|kirp:1 ENST00000337706 2 3d FGF1 P149 149 792 1z4s_A(0.0984);3fjd_B(0.0922);1jt7_C(0.0941);3fgm_B(0.0872);1jt7_D(0.0916);3fgm_A(0.0878);1m16_B(0.089);3ojm_A(0.0986);1nzk_A(0.0838);1nzk_B(0.0872);1nzk_C(0.082);1jt7_A(0.0952);1jt7_B(0.0945);1nzk_D(0.0848);1m16_A(0.0988);1ry7_A(0.0999);2uus_A(0.0971);2uus_B(0.0983) Cluster-exclusive S:1 0.082 1 1 skcm:1 ENST00000337706 2 3d FGF1 P151 151 792 1z4s_A(0.0984);3fjd_B(0.0922);1jt7_C(0.0941);3fgm_B(0.0872);1jt7_D(0.0916);3fgm_A(0.0878);1m16_B(0.089);3ojm_A(0.0986);1nzk_A(0.0838);1nzk_B(0.0872);1nzk_C(0.082);1jt7_A(0.0952);1jt7_B(0.0945);1nzk_D(0.0848);1m16_A(0.0988);1ry7_A(0.0999);2uus_A(0.0971);2uus_B(0.0983) Cluster-exclusive L:1 0.082 1 1 cscc:1 ENST00000337706 2 3d BRAF Q609 609 793 4pp7_B(0.0821) Hotspot-linked E:1|H:1 0.0821 2 2 hnsc:1|lusc:1 ENST00000288602 6 3d CLTCL1 G464 464 794 1agq_B(0.0876);1agq_C(0.0821);1agq_D(0.0941);3fub_D(0.0982) Cluster-exclusive R:1 0.0821 1 1 kirc:1 ENST00000427926 1 3d CLTCL1 D465 465 794 1agq_B(0.0876);1agq_C(0.0821);1agq_D(0.0941);3fub_D(0.0982) Cluster-exclusive E:1 0.0821 1 1 skcm:1 ENST00000427926 1 3d TF E394 394 795 3s9n_D(0.0822) Cluster-exclusive K:6 0.0822 6 3 coadread:1|skcm:4|ucec:1 ENST00000402696 3 3d TF D395 395 795 3s9n_D(0.0822) Cluster-exclusive E:1 0.0822 1 1 coadread:1 ENST00000402696 3 3d TF A398 398 795 3s9n_D(0.0822) Cluster-exclusive S:1|T:1 0.0822 2 2 coadread:1|lusc:1 ENST00000402696 3 3d TF S687 687 795 3s9n_D(0.0822) Cluster-exclusive L:1 0.0822 1 1 lusc:1 ENST00000402696 3 3d CASP6 S211 211 796 3qnw_H(0.0919);3qnw_B(0.0905);3p4u_B(0.0893);3qnw_F(0.0823);3qnw_D(0.0887) Cluster-exclusive P:1|C:1 0.0823 2 2 skcm:1|lihc:1 ENST00000265164 2 3d CASP6 V212 212 796 3qnw_H(0.0919);3qnw_B(0.0905);3p4u_B(0.0893);3qnw_F(0.0823);3qnw_D(0.0887) Cluster-exclusive L:1 0.0823 1 1 gbm:1 ENST00000265164 2 3d CASP6 A213 213 796 3qnw_H(0.0919);3qnw_B(0.0905);3p4u_B(0.0893);3qnw_F(0.0823);3qnw_D(0.0887) Cluster-exclusive T:1 0.0823 1 1 luad:1 ENST00000265164 2 3d CASP6 G215 215 796 3qnw_H(0.0919);3qnw_B(0.0905);3p4u_B(0.0893);3qnw_F(0.0823);3qnw_D(0.0887) Cluster-exclusive R:1 0.0823 1 1 mmyl:1 ENST00000265164 2 3d CASP6 P276 276 796 3qnw_H(0.0919);3qnw_B(0.0905);3p4u_B(0.0893);3qnw_F(0.0823);3qnw_D(0.0887) Cluster-exclusive S:1 0.0823 1 1 brca:1 ENST00000265164 2 3d LDB1 G351 351 797 2xjy_B(0.0853);2xjz_M(0.0824) Cluster-exclusive R:2|E:1 0.0824 3 2 paad:1|cesc:2 ENST00000425280 1 3d LDB1 E353 353 797 2xjy_B(0.0853);2xjz_M(0.0824) Cluster-exclusive K:1 0.0824 1 1 coadread:1 ENST00000425280 1 3d LDB1 E355 355 797 2xjy_B(0.0853);2xjz_M(0.0824) Cluster-exclusive K:1 0.0824 1 1 blca:1 ENST00000425280 1 3d TAF4B T474 474 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive A:1 0.0825 1 1 esca:1 ENST00000269142 5 3d TAF4B P486 486 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive H:1 0.0825 1 1 paad:1 ENST00000269142 5 3d TAF4B V487 487 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive D:1 0.0825 1 1 esca:1 ENST00000269142 5 3d TAF4B V488 488 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive D:1 0.0825 1 1 skcm:1 ENST00000269142 5 3d TAF4B G512 512 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive S:1 0.0825 1 1 luad:1 ENST00000269142 5 3d TAF4B R611 611 798 3f5n_A(0.0849);3fgq_A(0.0849);3f5n_D(0.0825) Cluster-exclusive L:1 0.0825 1 1 coadread:1 ENST00000269142 5 3d SMARCC2 R599 599 800 2yus_A(0.0827) Cluster-exclusive H:1 0.0827 1 1 stad:1 ENST00000267064 4 3d SMARCC2 G628 628 800 2yus_A(0.0827) Cluster-exclusive E:1 0.0827 1 1 blca:1 ENST00000267064 4 3d SMARCC2 R630 630 800 2yus_A(0.0827) Cluster-exclusive P:1|H:1 0.0827 2 2 stad:1|lusc:1 ENST00000267064 4 3d SMARCC2 E634 634 800 2yus_A(0.0827) Cluster-exclusive K:3 0.0827 3 2 stad:2|hnsc:1 ENST00000267064 4 3d SMARCC2 H638 638 800 2yus_A(0.0827) Cluster-exclusive D:1 0.0827 1 1 lihc:1 ENST00000267064 4 3d NSD1 E1970 1970 801 3ooi_A(0.083) Cluster-exclusive A:1|D:1 0.083 2 2 hnsc:1|mbl:1 ENST00000439151 2 3d NSD1 L1999 1999 801 3ooi_A(0.083) Cluster-exclusive R:1 0.083 1 1 coadread:1 ENST00000439151 2 3d NSD1 I2007 2007 801 3ooi_A(0.083) Cluster-exclusive T:1 0.083 1 1 luad:1 ENST00000439151 2 3d NSD1 T2029 2029 801 3ooi_A(0.083) Cluster-exclusive A:2 0.083 2 1 cll:2 ENST00000439151 2 3d NSD1 R2039 2039 801 3ooi_A(0.083) Cluster-exclusive S:2|H:1 0.083 3 2 stad:1|kirp:2 ENST00000439151 2 3d NSD1 V2040 2040 801 3ooi_A(0.083) Cluster-exclusive I:1 0.083 1 1 esca:1 ENST00000439151 2 3d CRPPA K278 278 802 4cvh_A(0.0831) Cluster-exclusive N:1 0.0831 1 1 luad:1 ENST00000407010 2 3d CRPPA E279 279 802 4cvh_A(0.0831) Cluster-exclusive D:1 0.0831 1 1 hnsc:1 ENST00000407010 2 3d CRPPA S282 282 802 4cvh_A(0.0831) Cluster-exclusive F:1 0.0831 1 1 skcm:1 ENST00000407010 2 3d CRPPA E284 284 802 4cvh_A(0.0831) Cluster-exclusive K:1 0.0831 1 1 skcm:1 ENST00000407010 2 3d CRPPA I285 285 802 4cvh_A(0.0831) Cluster-exclusive M:1 0.0831 1 1 stad:1 ENST00000407010 2 3d CRPPA K438 438 802 4cvh_A(0.0831) Cluster-exclusive N:1 0.0831 1 1 coadread:1 ENST00000407010 2 3d TNR P255 255 803 3ho5_A(0.0832) Cluster-exclusive A:1|S:1 0.0832 2 2 stad:1|luad:1 ENST00000263525 2 3d TNR T257 257 803 3ho5_A(0.0832) Cluster-exclusive I:1 0.0832 1 1 luad:1 ENST00000263525 2 3d TNR E259 259 803 3ho5_A(0.0832) Cluster-exclusive K:2 0.0832 2 2 brca:1|skcm:1 ENST00000263525 2 3d TNR E263 263 803 3ho5_A(0.0832) Cluster-exclusive K:6 0.0832 6 2 skcm:5|luad:1 ENST00000263525 2 3d TNR G289 289 803 3ho5_A(0.0832) Cluster-exclusive C:1 0.0832 1 1 acc:1 ENST00000263525 2 3d TNR D291 291 803 3ho5_A(0.0832) Cluster-exclusive H:1 0.0832 1 1 skcm:1 ENST00000263525 2 3d TNR P329 329 803 3ho5_A(0.0832) Cluster-exclusive R:1|T:1 0.0832 2 2 paad:1|luad:1 ENST00000263525 2 3d SETD2 S1624 1624 804 4h12_A(0.0834) Cluster-exclusive C:1 0.0834 1 1 luad:1 ENST00000409792 3 3d SETD2 R1625 1625 804 4h12_A(0.0834) Cluster-exclusive C:1|S:1|H:2|L:1 0.0834 5 5 brca:1|skcm:1|lusc:1|kirc:1|luad:1 ENST00000409792 3 3d SETD2 M1627 1627 804 4h12_A(0.0834) Cluster-exclusive R:1 0.0834 1 1 kirc:1 ENST00000409792 3 3d SETD2 H1629 1629 804 4h12_A(0.0834) Cluster-exclusive Y:3 0.0834 3 3 blca:1|skcm:1|kirc:1 ENST00000409792 3 3d SETD2 F1650 1650 804 4h12_A(0.0834) Cluster-exclusive S:1|V:1 0.0834 2 2 coadread:1|kirc:1 ENST00000409792 3 3d SETD2 Y1666 1666 804 4h12_A(0.0834) Cluster-exclusive H:1 0.0834 1 1 kirc:1 ENST00000409792 3 3d MOB1B Q165 165 805 1r3b_A(0.0834) Cluster-exclusive K:1 0.0834 1 1 lihc:1 ENST00000309395 2 3d CSNK1G1 L131 131 806 2c47_D(0.0837);2c47_C(0.0926);2c47_B(0.0944);2c47_A(0.0986) Cluster-exclusive P:1 0.0837 1 1 lihc:1 ENST00000303052 7 3d CSNK1G1 R134 134 806 2c47_D(0.0837);2c47_C(0.0926);2c47_B(0.0944);2c47_A(0.0986) Cluster-exclusive Q:1 0.0837 1 1 stad:1 ENST00000303052 7 3d CSNK1G1 T135 135 806 2c47_D(0.0837);2c47_C(0.0926);2c47_B(0.0944);2c47_A(0.0986) Cluster-exclusive I:1 0.0837 1 1 blca:1 ENST00000303052 7 3d CSNK1G1 R231 231 806 2c47_D(0.0837);2c47_C(0.0926);2c47_B(0.0944);2c47_A(0.0986) Cluster-exclusive T:1 0.0837 1 1 skcm:1 ENST00000303052 7 3d CSNK1G1 D232 232 806 2c47_D(0.0837);2c47_C(0.0926);2c47_B(0.0944);2c47_A(0.0986) Cluster-exclusive N:1 0.0837 1 1 acc:1 ENST00000303052 7 3d CACNA1B S1237 1237 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive L:1 0.0839 1 1 coadread:1 ENST00000371372 1 3d CACNA1B R1254 1254 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive H:1 0.0839 1 1 ucec:1 ENST00000371372 1 3d CACNA1B V1255 1255 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive I:1 0.0839 1 1 dlbc:1 ENST00000371372 1 3d CACNA1B R1257 1257 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive Q:1 0.0839 1 1 coadread:1 ENST00000371372 1 3d CACNA1B K1260 1260 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive N:1 0.0839 1 1 ucec:1 ENST00000371372 1 3d CACNA1B L1268 1268 807 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive V:1 0.0839 1 1 nbl:1 ENST00000371372 1 3d CACNA1B T1261 1261 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive I:1 0.0839 1 1 skcm:1 ENST00000371372 1 3d CACNA1B K1269 1269 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive T:1 0.0839 1 1 skcm:1 ENST00000371372 1 3d SMC1A A616 616 809 2wd5_A(0.0842) Cluster-exclusive V:1 0.0842 1 1 gbm:1 ENST00000322213 4 3d SMC1A R635 635 809 2wd5_A(0.0842) Cluster-exclusive H:1 0.0842 1 1 ucec:1 ENST00000322213 4 3d SMC1A K637 637 809 2wd5_A(0.0842) Cluster-exclusive R:1 0.0842 1 1 ucec:1 ENST00000322213 4 3d SMC1A T638 638 809 2wd5_A(0.0842) Cluster-exclusive K:1 0.0842 1 1 gbm:1 ENST00000322213 4 3d SMC1A F646 646 809 2wd5_A(0.0842) Cluster-exclusive L:1 0.0842 1 1 lihc:1 ENST00000322213 4 3d SMC1A Q647 647 809 2wd5_A(0.0842) Cluster-exclusive H:1 0.0842 1 1 coadread:1 ENST00000322213 4 3d SMC1A S649 649 810 2wd5_A(0.0842) Cluster-exclusive L:1 0.0842 1 1 ucs:1 ENST00000322213 4 3d NCF1 F117 117 812 1gd5_A(0.0845) Cluster-exclusive V:1 0.0845 1 1 stad:1 ENST00000289473 4 3d NCF1 F118 118 812 1gd5_A(0.0845) Cluster-exclusive L:1 0.0845 1 1 brca:1 ENST00000289473 4 3d NCF1 V120 120 812 1gd5_A(0.0845) Cluster-exclusive M:1 0.0845 1 1 cscc:1 ENST00000289473 4 3d NCF1 R121 121 812 1gd5_A(0.0845) Cluster-exclusive C:3 0.0845 3 3 coadread:1|stad:1|hnsc:1 ENST00000289473 4 3d NCF1 D123 123 812 1gd5_A(0.0845) Cluster-exclusive N:1 0.0845 1 1 luad:1 ENST00000289473 4 3d NCF1 H51 51 813 1gd5_A(0.0845) Cluster-exclusive Q:1 0.0845 1 1 luad:1 ENST00000289473 4 3d CREBBP T396 396 815 1l8c_A(0.0847) Cluster-exclusive R:2|M:1 0.0847 3 3 acc:1|stad:1|luad:1 ENST00000262367 5 3d CREBBP G401 401 815 1l8c_A(0.0847) Cluster-exclusive W:1 0.0847 1 1 skcm:1 ENST00000262367 5 3d CREBBP A410 410 815 1l8c_A(0.0847) Cluster-exclusive V:1 0.0847 1 1 coadread:1 ENST00000262367 5 3d CREBBP R413 413 815 1l8c_A(0.0847) Cluster-exclusive Q:1 0.0847 1 1 coadread:1 ENST00000262367 5 3d CREBBP I416 416 815 1l8c_A(0.0847) Cluster-exclusive V:1 0.0847 1 1 skcm:1 ENST00000262367 5 3d CCT3 R237 237 816 3iyg_G(0.0847) Cluster-exclusive C:1|H:2 0.0847 3 3 brca:1|prad:1|esca:1 ENST00000295688 3 3d CCT3 P287 287 816 3iyg_G(0.0847) Cluster-exclusive S:1 0.0847 1 1 lihc:1 ENST00000295688 3 3d CCT3 D288 288 816 3iyg_G(0.0847) Cluster-exclusive N:1 0.0847 1 1 luad:1 ENST00000295688 3 3d H3C8 R43 43 818 4h9s_B(0.0852);4h9n_A(0.0998) Cluster-exclusive C:1|H:1|L:1 0.0852 3 3 brca:1|paad:1|prad:1 ENST00000305910 3 3d H3C8 P44 44 818 4h9s_B(0.0852);4h9n_A(0.0998) Cluster-exclusive T:1|L:1 0.0852 2 2 brca:1|luad:1 ENST00000305910 3 3d H3C8 G45 45 818 4h9s_B(0.0852);4h9n_A(0.0998) Cluster-exclusive V:1 0.0852 1 1 hnsc:1 ENST00000305910 3 3d H3C8 T46 46 818 4h9s_B(0.0852);4h9n_A(0.0998) Cluster-exclusive N:1 0.0852 1 1 luad:1 ENST00000305910 3 3d ATP7A M497 497 819 1gxd_A(0.0853);1gxd_B(0.0903);1eak_A(0.0899) Cluster-exclusive I:1 0.0853 1 1 brca:1 ENST00000341514 6 3d ATP7A R508 508 819 1gxd_A(0.0853);1gxd_B(0.0903);1eak_A(0.0899) Cluster-exclusive W:1 0.0853 1 1 blca:1 ENST00000341514 6 3d ATP7A R512 512 819 1gxd_A(0.0853);1gxd_B(0.0903);1eak_A(0.0899) Cluster-exclusive W:2|L:1 0.0853 3 3 mbl:1|skcm:1|luad:1 ENST00000341514 6 3d ATP7A Y532 532 819 1gxd_A(0.0853);1gxd_B(0.0903);1eak_A(0.0899) Cluster-exclusive H:1 0.0853 1 1 stad:1 ENST00000341514 6 3d ATP7A I537 537 819 1gxd_A(0.0853);1gxd_B(0.0903);1eak_A(0.0899) Cluster-exclusive T:1|M:1 0.0853 2 1 coadread:2 ENST00000341514 6 3d ALOX15B S310 310 820 4nre_A(0.0853) Cluster-exclusive Y:1 0.0853 1 1 coadread:1 ENST00000380183 4 3d ALOX15B R361 361 820 4nre_A(0.0853) Cluster-exclusive C:1 0.0853 1 1 ucec:1 ENST00000380183 4 3d ALOX15B A363 363 820 4nre_A(0.0853) Cluster-exclusive V:1 0.0853 1 1 ov:1 ENST00000380183 4 3d ALOX15B E364 364 820 4nre_A(0.0853) Cluster-exclusive K:1 0.0853 1 1 luad:1 ENST00000380183 4 3d ALOX15B S366 366 820 4nre_A(0.0853) Cluster-exclusive F:1 0.0853 1 1 skcm:1 ENST00000380183 4 3d ALOX15B F438 438 820 4nre_A(0.0853) Cluster-exclusive L:1 0.0853 1 1 ucec:1 ENST00000380183 4 3d ALOX15B P572 572 820 4nre_A(0.0853) Cluster-exclusive L:1 0.0853 1 1 luad:1 ENST00000380183 4 3d IL13RA2 A103 103 821 3lb6_C(0.0853) Cluster-exclusive V:1 0.0853 1 1 coadread:1 ENST00000243213 1 3d KIT W557 557 823 4hvs_A(0.0854) Cluster-exclusive R:1 0.0854 1 1 skcm:1 ENST00000288135 5 3d KIT V559 559 823 4hvs_A(0.0854) Cluster-exclusive A:3 0.0854 3 1 skcm:3 ENST00000288135 5 3d KIT V560 560 823 4hvs_A(0.0854) Cluster-exclusive A:1 0.0854 1 1 stad:1 ENST00000288135 5 3d KIT L576 576 823 4hvs_A(0.0854) Cluster-exclusive P:2 0.0854 2 1 skcm:2 ENST00000288135 5 3d KIT P573 573 824 4hvs_A(0.0854) Cluster-exclusive Q:1|L:1 0.0854 2 2 lihc:1|luad:1 ENST00000288135 5 3d RTL5 R533 533 825 2bb5_A(0.0855) Cluster-exclusive C:1 0.0855 1 1 coadread:1 ENST00000479991 1 3d RTL5 R534 534 825 2bb5_A(0.0855) Cluster-exclusive H:1 0.0855 1 1 prad:1 ENST00000479991 1 3d RTL5 R541 541 825 2bb5_A(0.0855) Cluster-exclusive C:1 0.0855 1 1 stad:1 ENST00000479991 1 3d RTL5 R544 544 825 2bb5_A(0.0855) Cluster-exclusive Q:1 0.0855 1 1 coadread:1 ENST00000479991 1 3d RTL5 R546 546 825 2bb5_A(0.0855) Cluster-exclusive C:1 0.0855 1 1 gbm:1 ENST00000479991 1 3d RTL5 P548 548 825 2bb5_A(0.0855) Cluster-exclusive S:1|T:1 0.0855 2 2 skcm:1|kirp:1 ENST00000479991 1 3d CAMK2D E18 18 826 3soa_A(0.0858) Cluster-exclusive Q:1 0.0858 1 1 luad:1 ENST00000342666 5 3d CAMK2D L20 20 826 3soa_A(0.0858) Cluster-exclusive V:1 0.0858 1 1 mmyl:1 ENST00000342666 5 3d CAMK2D K22 22 826 3soa_A(0.0858) Cluster-exclusive E:1 0.0858 1 1 mmyl:1 ENST00000342666 5 3d CAMK2D S26 26 826 3soa_A(0.0858) Cluster-exclusive L:1 0.0858 1 1 lusc:1 ENST00000342666 5 3d CAMK2D V28 28 826 3soa_A(0.0858) Cluster-exclusive L:1 0.0858 1 1 luad:1 ENST00000342666 5 3d CAMK2D R29 29 826 3soa_A(0.0858) Cluster-exclusive K:1 0.0858 1 1 ucs:1 ENST00000342666 5 3d S100A2 H17 17 827 2rgi_A(0.0859) Cluster-exclusive Y:1 0.0859 1 1 skcm:1 ENST00000368708 3 3d S100A2 C21 21 827 2rgi_A(0.0859) Cluster-exclusive Y:1 0.0859 1 1 lusm:1 ENST00000368708 3 3d S100A2 S30 30 827 2rgi_A(0.0859) Cluster-exclusive I:1 0.0859 1 1 ucec:1 ENST00000368708 3 3d S100A2 L38 38 827 2rgi_A(0.0859) Cluster-exclusive V:1 0.0859 1 1 hnsc:1 ENST00000368708 3 3d S100A2 V70 70 827 2rgi_A(0.0859) Cluster-exclusive G:1 0.0859 1 1 brca:1 ENST00000368708 3 3d S100A2 D71 71 827 2rgi_A(0.0859) Cluster-exclusive N:1 0.0859 1 1 coadread:1 ENST00000368708 3 3d GLRX2 T54 54 828 2cq9_A(0.086) Cluster-exclusive K:1 0.086 1 1 ucs:1 ENST00000367439 3 3d GLRX2 P56 56 828 2cq9_A(0.086) Cluster-exclusive S:1|H:1 0.086 2 2 lusc:1|cesc:1 ENST00000367439 3 3d GLRX2 N58 58 828 2cq9_A(0.086) Cluster-exclusive D:1 0.086 1 1 lihc:1 ENST00000367439 3 3d GLRX2 D110 110 828 2cq9_A(0.086) Cluster-exclusive G:1 0.086 1 1 lihc:1 ENST00000367439 3 3d UGP2 D253 253 830 3r2w_C(0.0905);3r3i_C(0.0862) Cluster-exclusive H:2 0.0862 2 1 blca:2 ENST00000337130 5 3d UGP2 L255 255 830 3r2w_C(0.0905);3r3i_C(0.0862) Cluster-exclusive M:2 0.0862 2 2 coadread:1|gbm:1 ENST00000337130 5 3d UGP2 A257 257 830 3r2w_C(0.0905);3r3i_C(0.0862) Cluster-exclusive V:1 0.0862 1 1 coadread:1 ENST00000337130 5 3d UGP2 L416 416 830 3r2w_C(0.0905);3r3i_C(0.0862) Cluster-exclusive V:2 0.0862 2 2 cscc:1|luad:1 ENST00000337130 5 3d FBXO44 F18 18 831 3wso_A(0.0862) Cluster-exclusive L:1 0.0862 1 1 ucec:1 ENST00000251547 5 3d FBXO44 L36 36 831 3wso_A(0.0862) Cluster-exclusive F:1 0.0862 1 1 blca:1 ENST00000251547 5 3d FBXO44 R38 38 831 3wso_A(0.0862) Cluster-exclusive Q:1 0.0862 1 1 stad:1 ENST00000251547 5 3d FBXO44 L40 40 831 3wso_A(0.0862) Cluster-exclusive P:1 0.0862 1 1 gbm:1 ENST00000251547 5 3d FBXO44 I41 41 831 3wso_A(0.0862) Cluster-exclusive V:1 0.0862 1 1 stad:1 ENST00000251547 5 3d POR F86 86 832 1b1c_A(0.0865) Cluster-exclusive L:1 0.0865 1 1 stad:1 ENST00000394893 1 3d POR S89 89 832 1b1c_A(0.0865) Cluster-exclusive C:1 0.0865 1 1 lusc:1 ENST00000394893 1 3d POR T91 91 832 1b1c_A(0.0865) Cluster-exclusive M:1 0.0865 1 1 kich:1 ENST00000394893 1 3d POR G92 92 832 1b1c_A(0.0865) Cluster-exclusive R:2 0.0865 2 1 cscc:2 ENST00000394893 1 3d MDFIC G108 108 834 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive R:1|E:1 0.0866 2 2 coadread:1|luad:1 ENST00000393486 1 3d MDFIC G112 112 834 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive R:2 0.0866 2 2 blca:1|ov:1 ENST00000393486 1 3d MDFIC A113 113 834 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive T:1 0.0866 1 1 coadread:1 ENST00000393486 1 3d MDFIC S128 128 834 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive F:1 0.0866 1 1 skcm:1 ENST00000393486 1 3d MDFIC K130 130 835 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive N:1 0.0866 1 1 kirc:1 ENST00000393486 1 3d RGS6 K331 331 836 2es0_A(0.0869) Cluster-exclusive T:1 0.0869 1 1 luad:1 ENST00000553530 1 3d RGS6 R332 332 836 2es0_A(0.0869) Cluster-exclusive I:1 0.0869 1 1 kirc:1 ENST00000553530 1 3d RGS6 W333 333 836 2es0_A(0.0869) Cluster-exclusive L:1 0.0869 1 1 brca:1 ENST00000553530 1 3d RGS6 S336 336 836 2es0_A(0.0869) Cluster-exclusive Y:1 0.0869 1 1 ucec:1 ENST00000553530 1 3d RGS6 E339 339 836 2es0_A(0.0869) Cluster-exclusive K:1 0.0869 1 1 skcm:1 ENST00000553530 1 3d RGS6 D343 343 836 2es0_A(0.0869) Cluster-exclusive N:1 0.0869 1 1 skcm:1 ENST00000553530 1 3d RGS6 V345 345 836 2es0_A(0.0869) Cluster-exclusive M:1 0.0869 1 1 lusc:1 ENST00000553530 1 3d SERPINB3 L4 4 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive V:1 0.0869 1 1 luad:1 ENST00000283752 5 3d PCBP1 R17 17 838 2jzx_A(0.087) Hotspot-linked W:1 0.087 1 1 cesc:1 ENST00000303577 5 3d PCBP1 L100 100 838 2jzx_A(0.087) Hotspot-linked P:1|Q:10 0.087 11 2 coadread:10|lihc:1 ENST00000303577 5 3d PCBP1 L102 102 838 2jzx_A(0.087) Hotspot P:1|Q:2|R:1 0.087 4 1 coadread:4 ENST00000303577 5 3d PCBP1 R144 144 838 2jzx_A(0.087) Hotspot-linked W:1 0.087 1 1 paad:1 ENST00000303577 5 3d H2AC12 R30 30 839 3an2_G(0.0873) Cluster-exclusive Q:1 0.0873 1 1 hnsc:1 ENST00000377459 1 3d H2AC12 L34 34 839 3an2_G(0.0873) Cluster-exclusive P:1|R:1 0.0873 2 2 prad:1|lusc:1 ENST00000377459 1 3d H2AC12 G45 45 839 3an2_G(0.0873) Cluster-exclusive E:1 0.0873 1 1 brca:1 ENST00000377459 1 3d H2AC12 A48 48 839 3an2_G(0.0873) Cluster-exclusive V:1 0.0873 1 1 hnsc:1 ENST00000377459 1 3d H2AC12 P49 49 839 3an2_G(0.0873) Cluster-exclusive T:1 0.0873 1 1 skcm:1 ENST00000377459 1 3d H2AC12 V50 50 839 3an2_G(0.0873) Cluster-exclusive M:1 0.0873 1 1 kirc:1 ENST00000377459 1 3d EPHB2 M927 927 840 1b4f_E(0.0874) Cluster-exclusive V:1 0.0874 1 1 luad:1 ENST00000400191 3 3d EPHB2 L954 954 840 1b4f_E(0.0874) Cluster-exclusive I:1 0.0874 1 1 ucec:1 ENST00000400191 3 3d EPHB2 A961 961 840 1b4f_E(0.0874) Cluster-exclusive T:1 0.0874 1 1 skcm:1 ENST00000400191 3 3d EPHB2 G962 962 840 1b4f_E(0.0874) Cluster-exclusive D:1 0.0874 1 1 gbm:1 ENST00000400191 3 3d EPHB2 Q964 964 840 1b4f_E(0.0874) Cluster-exclusive R:1 0.0874 1 1 luad:1 ENST00000400191 3 3d EPHB2 N969 969 840 1b4f_E(0.0874) Cluster-exclusive Y:1 0.0874 1 1 lusc:1 ENST00000400191 3 3d EIF4A2 R335 335 841 1lq8_G(0.0875) Cluster-exclusive C:1 0.0875 1 1 cscc:1 ENST00000323963 5 3d EIF4A2 G336 336 841 1lq8_G(0.0875) Cluster-exclusive E:1|W:1 0.0875 2 2 skcm:1|ucec:1 ENST00000323963 5 3d EIF4A2 R369 369 841 1lq8_G(0.0875) Cluster-exclusive S:1 0.0875 1 1 brca:1 ENST00000323963 5 3d EIF4A2 R386 386 841 1lq8_G(0.0875) Cluster-exclusive S:1|G:1|H:1 0.0875 3 2 coadread:2|ucec:1 ENST00000323963 5 3d EIF4A2 E389 389 841 1lq8_G(0.0875) Cluster-exclusive Q:1|K:1 0.0875 2 2 brca:1|mmyl:1 ENST00000323963 5 3d MLST8 R221 221 842 4lla_A(0.0876) Cluster-exclusive H:1 0.0876 1 1 gbm:1 ENST00000397124 1 3d MLST8 A223 223 842 4lla_A(0.0876) Cluster-exclusive T:2 0.0876 2 2 coadread:1|stad:1 ENST00000397124 1 3d MLST8 R248 248 842 4lla_A(0.0876) Cluster-exclusive M:1 0.0876 1 1 ucec:1 ENST00000397124 1 3d PTPN11 K55 55 843 4fr4_D(0.0945);4fr4_C(0.0894);4fr4_E(0.0879);4fr4_B(0.0956);4fr4_A(0.0928) Hotspot-linked N:1 0.0879 1 1 ucec:1 ENST00000351677 2 3d ANXA6 A605 605 846 1avc_A(0.0881) Cluster-exclusive T:1 0.0881 1 1 ucec:1 ENST00000354546 5 3d ANXA6 D606 606 846 1avc_A(0.0881) Cluster-exclusive E:1|G:1 0.0881 2 2 stad:1|lusc:1 ENST00000354546 5 3d ANXA6 K607 607 846 1avc_A(0.0881) Cluster-exclusive T:1 0.0881 1 1 coadread:1 ENST00000354546 5 3d ANXA6 Y609 609 846 1avc_A(0.0881) Cluster-exclusive D:1 0.0881 1 1 dlbc:1 ENST00000354546 5 3d ANXA6 S611 611 846 1avc_A(0.0881) Cluster-exclusive F:1 0.0881 1 1 skcm:1 ENST00000354546 5 3d ANXA6 M612 612 846 1avc_A(0.0881) Cluster-exclusive T:1 0.0881 1 1 ucec:1 ENST00000354546 5 3d PPP2R1A R105 105 847 2ie4_A(0.0883) Hotspot-linked Q:1 0.0883 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A R134 134 847 2ie4_A(0.0883) Cluster-exclusive W:1 0.0883 1 1 coadread:1 ENST00000322088 6 3d DUSP9 V300 300 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive I:1 0.0883 1 1 kich:1 ENST00000342782 3 3d DUSP9 A303 303 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive S:1 0.0883 1 1 nbl:1 ENST00000342782 3 3d DUSP9 S343 343 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive T:1 0.0883 1 1 luad:1 ENST00000342782 3 3d DUSP9 R345 345 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive W:1 0.0883 1 1 paad:1 ENST00000342782 3 3d DUSP9 S351 351 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive L:1 0.0883 1 1 skcm:1 ENST00000342782 3 3d DUSP9 Q352 352 848 4j2x_A(0.0883);3iag_C(0.0909) Cluster-exclusive P:1 0.0883 1 1 hnsc:1 ENST00000342782 3 3d CTSD P204 204 849 4od9_D(0.0884);4od9_B(0.0895) Cluster-exclusive L:1 0.0884 1 1 lusm:1 ENST00000236671 2 3d CTSD R205 205 849 4od9_D(0.0884);4od9_B(0.0895) Cluster-exclusive H:1 0.0884 1 1 lihc:1 ENST00000236671 2 3d CTSD S207 207 849 4od9_D(0.0884);4od9_B(0.0895) Cluster-exclusive F:1 0.0884 1 1 acc:1 ENST00000236671 2 3d CTSD R266 266 849 4od9_D(0.0884);4od9_B(0.0895) Cluster-exclusive C:2 0.0884 2 2 cscc:1|kirp:1 ENST00000236671 2 3d CTSD A268 268 849 4od9_D(0.0884);4od9_B(0.0895) Cluster-exclusive T:1|V:1 0.0884 2 2 gbm:1|luad:1 ENST00000236671 2 3d CASP7 S231 231 851 1gqf_A(0.0973);1gqf_B(0.0885);1k88_B(0.0935) Cluster-exclusive L:2 0.0885 2 2 ucs:1|skcm:1 ENST00000345633 4 3d CASP7 R233 233 851 1gqf_A(0.0973);1gqf_B(0.0885);1k88_B(0.0935) Cluster-exclusive W:1 0.0885 1 1 kirc:1 ENST00000345633 4 3d CASP7 S234 234 851 1gqf_A(0.0973);1gqf_B(0.0885);1k88_B(0.0935) Cluster-exclusive N:1 0.0885 1 1 coadread:1 ENST00000345633 4 3d CASP7 P235 235 851 1gqf_A(0.0973);1gqf_B(0.0885);1k88_B(0.0935) Cluster-exclusive S:1 0.0885 1 1 skcm:1 ENST00000345633 4 3d CASP7 G236 236 851 1gqf_A(0.0973);1gqf_B(0.0885);1k88_B(0.0935) Cluster-exclusive E:1 0.0885 1 1 hnsc:1 ENST00000345633 4 3d SH3GL1 G23 23 854 2d4c_D(0.0889) Cluster-exclusive V:1 0.0889 1 1 stad:1 ENST00000269886 3 3d SH3GL1 A24 24 854 2d4c_D(0.0889) Cluster-exclusive S:1 0.0889 1 1 blca:1 ENST00000269886 3 3d SH3GL1 E25 25 854 2d4c_D(0.0889) Cluster-exclusive K:1 0.0889 1 1 coadread:1 ENST00000269886 3 3d SH3GL1 G26 26 854 2d4c_D(0.0889) Cluster-exclusive W:1 0.0889 1 1 kirp:1 ENST00000269886 3 3d LGALS9 P270 270 855 3nv3_A(0.0955);3nv2_A(0.089);3nv1_A(0.0951) Cluster-exclusive S:1 0.089 1 1 skcm:1 ENST00000395473 2 3d LGALS9 R271 271 855 3nv3_A(0.0955);3nv2_A(0.089);3nv1_A(0.0951) Cluster-exclusive H:1 0.089 1 1 coadread:1 ENST00000395473 2 3d LGALS9 A276 276 855 3nv3_A(0.0955);3nv2_A(0.089);3nv1_A(0.0951) Cluster-exclusive S:1 0.089 1 1 luad:1 ENST00000395473 2 3d LGALS9 R292 292 855 3nv3_A(0.0955);3nv2_A(0.089);3nv1_A(0.0951) Cluster-exclusive Q:1 0.089 1 1 skcm:1 ENST00000395473 2 3d LGALS9 M298 298 855 3nv3_A(0.0955);3nv2_A(0.089);3nv1_A(0.0951) Cluster-exclusive V:1 0.089 1 1 brca:1 ENST00000395473 2 3d SETBP1 K934 934 858 3mrr_A(0.0916);2x4r_A(0.0992);3nfn_A(0.0985);3vxp_A(0.0953);3vxn_A(0.1);3mrf_A(0.0958);3mri_A(0.0908);2c7u_A(0.0924);3mrd_A(0.099);3mre_A(0.0982);4f7p_A(0.0985);3vxu_A(0.0894);1qsf_A(0.0946);1hhh_A(0.0921) Cluster-exclusive N:1 0.0894 1 1 coadread:1 ENST00000282030 5 3d RALYL G101 101 861 4b18_A(0.0901) Cluster-exclusive E:1 0.0901 1 1 skcm:1 ENST00000521268 1 3d RALYL K103 103 861 4b18_A(0.0901) Cluster-exclusive E:1 0.0901 1 1 prad:1 ENST00000521268 1 3d RALYL R104 104 861 4b18_A(0.0901) Cluster-exclusive G:1 0.0901 1 1 lihc:1 ENST00000521268 1 3d RALYL L106 106 861 4b18_A(0.0901) Cluster-exclusive P:1 0.0901 1 1 lusc:1 ENST00000521268 1 3d RALYL S107 107 861 4b18_A(0.0901) Cluster-exclusive P:1 0.0901 1 1 ov:1 ENST00000521268 1 3d ENPP6 S46 46 862 1kn0_A(0.0909);1h2i_A(0.0906) Cluster-exclusive L:1 0.0906 1 1 cscc:1 ENST00000296741 2 3d ENPP6 G49 49 862 1kn0_A(0.0909);1h2i_A(0.0906) Cluster-exclusive V:1 0.0906 1 1 ucec:1 ENST00000296741 2 3d ENPP6 F50 50 862 1kn0_A(0.0909);1h2i_A(0.0906) Cluster-exclusive L:1 0.0906 1 1 ucec:1 ENST00000296741 2 3d ENPP6 E52 52 862 1kn0_A(0.0909);1h2i_A(0.0906) Cluster-exclusive D:3 0.0906 3 2 coadread:2|ucec:1 ENST00000296741 2 3d ENPP6 R82 82 862 1kn0_A(0.0909);1h2i_A(0.0906) Cluster-exclusive C:1|H:2 0.0906 3 3 coadread:1|cll:1|gbm:1 ENST00000296741 2 3d USP5 R191 191 863 2g43_B(0.0906) Cluster-exclusive Q:2 0.0906 2 2 brca:1|coadread:1 ENST00000229268 8 3d USP5 P193 193 863 2g43_B(0.0906) Cluster-exclusive S:1 0.0906 1 1 skcm:1 ENST00000229268 8 3d USP5 P194 194 863 2g43_B(0.0906) Cluster-exclusive L:2 0.0906 2 2 hnsc:1|skcm:1 ENST00000229268 8 3d USP5 W197 197 863 2g43_B(0.0906) Cluster-exclusive C:1 0.0906 1 1 luad:1 ENST00000229268 8 3d GAS2L3 E186 186 865 2i6q_A(0.0907) Cluster-exclusive Q:1 0.0907 1 1 hnsc:1 ENST00000266754 5 3d GAS2L3 E189 189 865 2i6q_A(0.0907) Cluster-exclusive D:1 0.0907 1 1 cscc:1 ENST00000266754 5 3d GAS2L3 S200 200 865 2i6q_A(0.0907) Cluster-exclusive F:1 0.0907 1 1 skcm:1 ENST00000266754 5 3d GAS2L3 I201 201 865 2i6q_A(0.0907) Cluster-exclusive V:1 0.0907 1 1 hnsc:1 ENST00000266754 5 3d GAS2L3 S202 202 865 2i6q_A(0.0907) Cluster-exclusive I:1 0.0907 1 1 ucec:1 ENST00000266754 5 3d GAS2L3 S387 387 865 2i6q_A(0.0907) Cluster-exclusive C:1 0.0907 1 1 luad:1 ENST00000266754 5 3d GAS2L3 S388 388 865 2i6q_A(0.0907) Cluster-exclusive L:1 0.0907 1 1 stad:1 ENST00000266754 5 3d CTLA4 A66 66 866 2x44_D(0.0907) Cluster-exclusive D:1 0.0907 1 1 coadread:1 ENST00000302823 3 3d CTLA4 V69 69 866 2x44_D(0.0907) Cluster-exclusive F:1 0.0907 1 1 luad:1 ENST00000302823 3 3d CTLA4 M91 91 866 2x44_D(0.0907) Cluster-exclusive T:1|I:1 0.0907 2 2 stad:1|skcm:1 ENST00000302823 3 3d CTLA4 S107 107 866 2x44_D(0.0907) Cluster-exclusive Y:1 0.0907 1 1 luad:1 ENST00000302823 3 3d CTLA4 G109 109 866 2x44_D(0.0907) Cluster-exclusive R:2 0.0907 2 1 cscc:2 ENST00000302823 3 3d H3C13 R135 135 867 1hq3_C(0.0907) Cluster-exclusive Q:1 0.0907 1 1 stad:1 ENST00000331491 1 3d ZSCAN16 R37 37 868 1e07_A(0.0907) Cluster-exclusive M:1 0.0907 1 1 hnsc:1 ENST00000340487 4 3d ZSCAN16 P53 53 868 1e07_A(0.0907) Cluster-exclusive H:1 0.0907 1 1 ucec:1 ENST00000340487 4 3d ZSCAN16 G54 54 868 1e07_A(0.0907) Cluster-exclusive E:1 0.0907 1 1 ucec:1 ENST00000340487 4 3d ZSCAN16 H105 105 869 1e07_A(0.0907) Cluster-exclusive Y:1 0.0907 1 1 cscc:1 ENST00000340487 4 3d PRLR P129 129 871 4i18_C(0.0908) Cluster-exclusive T:1 0.0908 1 1 lusm:1 ENST00000618457 3d PRLR E169 169 871 4i18_C(0.0908) Cluster-exclusive K:1 0.0908 1 1 skcm:1 ENST00000618457 3d PRLR I170 170 871 4i18_C(0.0908) Cluster-exclusive T:1 0.0908 1 1 skcm:1 ENST00000618457 3d PRLR R171 171 871 4i18_C(0.0908) Cluster-exclusive Q:1|L:1 0.0908 2 2 prad:1|skcm:1 ENST00000618457 3d PRLR R207 207 871 4i18_C(0.0908) Cluster-exclusive C:2 0.0908 2 1 skcm:2 ENST00000618457 3d PRLR W218 218 871 4i18_C(0.0908) Cluster-exclusive G:1 0.0908 1 1 hnsc:1 ENST00000618457 3d PRLR S219 219 871 4i18_C(0.0908) Cluster-exclusive R:1 0.0908 1 1 skcm:1 ENST00000618457 3d TRAF2 A375 375 872 1czz_A(0.0909);1czz_C(0.0934) Cluster-exclusive T:2 0.0909 2 2 gbm:1|mbl:1 ENST00000247668 2 3d TRAF2 S378 378 872 1czz_A(0.0909);1czz_C(0.0934) Cluster-exclusive F:1 0.0909 1 1 skcm:1 ENST00000247668 2 3d TRAF2 R393 393 872 1czz_A(0.0909);1czz_C(0.0934) Cluster-exclusive H:1 0.0909 1 1 cesc:1 ENST00000247668 2 3d TRAF2 S408 408 872 1czz_A(0.0909);1czz_C(0.0934) Cluster-exclusive F:1 0.0909 1 1 skcm:1 ENST00000247668 2 3d TRAF2 A466 466 872 1czz_A(0.0909);1czz_C(0.0934) Cluster-exclusive T:1 0.0909 1 1 ucec:1 ENST00000247668 2 3d APOC1 R49 49 873 1opp_A(0.0909) Cluster-exclusive W:1 0.0909 1 1 skcm:1 ENST00000588750 1 3d APOC1 I52 52 873 1opp_A(0.0909) Cluster-exclusive M:1|N:1 0.0909 2 2 hnsc:1|lihc:1 ENST00000588750 1 3d APOC1 R54 54 873 1opp_A(0.0909) Cluster-exclusive H:1 0.0909 1 1 ucec:1 ENST00000588750 1 3d APOC1 I55 55 873 1opp_A(0.0909) Cluster-exclusive M:1 0.0909 1 1 lusm:1 ENST00000588750 1 3d EGFR R836 836 874 3w32_A(0.091) Cluster-exclusive H:1 0.091 1 1 blca:1 ENST00000275493 2 3d EGFR F856 856 874 3w32_A(0.091) Cluster-exclusive L:1 0.091 1 1 luad:1 ENST00000275493 2 3d ANKRD30B E300 300 875 1ey2_A(0.091) Cluster-exclusive K:1 0.091 1 1 cscc:1 ENST00000358984 4 3d ANKRD30B C374 374 875 1ey2_A(0.091) Cluster-exclusive W:1 0.091 1 1 gbm:1 ENST00000358984 4 3d ANKRD30B R483 483 875 1ey2_A(0.091) Cluster-exclusive Q:3 0.091 3 3 kich:1|skcm:1|lgg:1 ENST00000358984 4 3d ANKRD30B E572 572 875 1ey2_A(0.091) Cluster-exclusive D:1 0.091 1 1 brca:1 ENST00000358984 4 3d ANKRD30B W575 575 875 1ey2_A(0.091) Cluster-exclusive C:1 0.091 1 1 acc:1 ENST00000358984 4 3d TBK1 M263 263 876 4eut_A(0.0911) Cluster-exclusive V:1 0.0911 1 1 coadread:1 ENST00000331710 5 3d TBK1 V265 265 876 4eut_A(0.0911) Cluster-exclusive A:1 0.0911 1 1 kich:1 ENST00000331710 5 3d TBK1 R271 271 876 4eut_A(0.0911) Cluster-exclusive P:1 0.0911 1 1 esca:1 ENST00000331710 5 3d TBK1 T278 278 876 4eut_A(0.0911) Cluster-exclusive I:1 0.0911 1 1 skcm:1 ENST00000331710 5 3d TBK1 L281 281 876 4eut_A(0.0911) Cluster-exclusive I:2 0.0911 2 2 gbm:1|ucec:1 ENST00000331710 5 3d MYO10 G1140 1140 878 4ah6_A(0.0914) Cluster-exclusive W:1 0.0914 1 1 lihc:1 ENST00000513610 1 3d MYO10 A1141 1141 878 4ah6_A(0.0914) Cluster-exclusive V:2 0.0914 2 1 coadread:2 ENST00000513610 1 3d MYO10 R1155 1155 878 4ah6_A(0.0914) Cluster-exclusive K:1 0.0914 1 1 coadread:1 ENST00000513610 1 3d CDK9 R303 303 880 4ec9_A(0.0959);3tn8_A(0.0987);4ec8_A(0.0926);3lq5_A(0.0985);3tni_A(0.0917);3blq_A(0.0959);4bcj_A(0.0995);3blr_A(0.0991);4bci_A(0.0965) Cluster-exclusive C:2 0.0917 2 2 paad:1|ucec:1 ENST00000373264 4 3d CDK9 D305 305 880 4ec9_A(0.0959);3tn8_A(0.0987);4ec8_A(0.0926);3lq5_A(0.0985);3tni_A(0.0917);3blq_A(0.0959);4bcj_A(0.0995);3blr_A(0.0991);4bci_A(0.0965) Cluster-exclusive A:1 0.0917 1 1 luad:1 ENST00000373264 4 3d CDK9 D307 307 880 4ec9_A(0.0959);3tn8_A(0.0987);4ec8_A(0.0926);3lq5_A(0.0985);3tni_A(0.0917);3blq_A(0.0959);4bcj_A(0.0995);3blr_A(0.0991);4bci_A(0.0965) Cluster-exclusive V:1 0.0917 1 1 lihc:1 ENST00000373264 4 3d CDK9 D308 308 880 4ec9_A(0.0959);3tn8_A(0.0987);4ec8_A(0.0926);3lq5_A(0.0985);3tni_A(0.0917);3blq_A(0.0959);4bcj_A(0.0995);3blr_A(0.0991);4bci_A(0.0965) Cluster-exclusive E:1 0.0917 1 1 cscc:1 ENST00000373264 4 3d CDK9 A309 309 880 4ec9_A(0.0959);3tn8_A(0.0987);4ec8_A(0.0926);3lq5_A(0.0985);3tni_A(0.0917);3blq_A(0.0959);4bcj_A(0.0995);3blr_A(0.0991);4bci_A(0.0965) Cluster-exclusive V:1 0.0917 1 1 cscc:1 ENST00000373264 4 3d PECR K298 298 881 1yxm_C(0.0917) Cluster-exclusive E:1|N:2 0.0917 3 3 ucec:1|lihc:1|kirp:1 ENST00000265322 7 3d PLEK K108 108 882 2ch6_B(0.0919) Cluster-exclusive T:1 0.0919 1 1 ucec:1 ENST00000234313 7 3d PLEK A110 110 882 2ch6_B(0.0919) Cluster-exclusive D:1 0.0919 1 1 luad:1 ENST00000234313 7 3d PLEK S113 113 882 2ch6_B(0.0919) Cluster-exclusive Y:1 0.0919 1 1 nbl:1 ENST00000234313 7 3d PLEK T114 114 882 2ch6_B(0.0919) Cluster-exclusive S:1 0.0919 1 1 hnsc:1 ENST00000234313 7 3d PLEK R115 115 882 2ch6_B(0.0919) Cluster-exclusive W:1 0.0919 1 1 luad:1 ENST00000234313 7 3d PLEK L131 131 882 2ch6_B(0.0919) Cluster-exclusive S:1 0.0919 1 1 coadread:1 ENST00000234313 7 3d PLEK S132 132 882 2ch6_B(0.0919) Cluster-exclusive A:1 0.0919 1 1 luad:1 ENST00000234313 7 3d PLEK K265 265 882 2ch6_B(0.0919) Cluster-exclusive T:1 0.0919 1 1 coadread:1 ENST00000234313 7 3d ZNF658 T839 839 883 3q25_A(0.0922) Cluster-exclusive I:1 0.0922 1 1 gbm:1 ENST00000612867 3d ZNF658 L841 841 883 3q25_A(0.0922) Cluster-exclusive P:1 0.0922 1 1 lihc:1 ENST00000612867 3d ZNF658 C842 842 883 3q25_A(0.0922) Cluster-exclusive Y:1 0.0922 1 1 kirc:1 ENST00000612867 3d ZNF658 R846 846 883 3q25_A(0.0922) Cluster-exclusive K:1 0.0922 1 1 gbm:1 ENST00000612867 3d RELA E39 39 884 2acm_A(0.0923) Cluster-exclusive K:2 0.0923 2 2 coadread:1|cesc:1 ENST00000406246 3 3d RELA G44 44 884 2acm_A(0.0923) Cluster-exclusive V:1 0.0923 1 1 luad:1 ENST00000406246 3 3d RELA K79 79 884 2acm_A(0.0923) Cluster-exclusive N:1 0.0923 1 1 kirp:1 ENST00000406246 3 3d SPEG V712 712 886 2ypt_E(0.0994);4aw6_A(0.0929);2ypt_A(0.0924) Cluster-exclusive M:1 0.0924 1 1 stad:1 ENST00000312358 7 3d SPEG S713 713 886 2ypt_E(0.0994);4aw6_A(0.0929);2ypt_A(0.0924) Cluster-exclusive P:1 0.0924 1 1 coadread:1 ENST00000312358 7 3d SPEG A714 714 886 2ypt_E(0.0994);4aw6_A(0.0929);2ypt_A(0.0924) Cluster-exclusive P:1 0.0924 1 1 luad:1 ENST00000312358 7 3d SPEG G715 715 886 2ypt_E(0.0994);4aw6_A(0.0929);2ypt_A(0.0924) Cluster-exclusive V:1 0.0924 1 1 lusc:1 ENST00000312358 7 3d F7 D147 147 888 1kli_L(0.0926) Cluster-exclusive N:1 0.0926 1 1 cscc:1 ENST00000375581 3 3d F7 T168 168 888 1kli_L(0.0926) Cluster-exclusive N:1 0.0926 1 1 luad:1 ENST00000375581 3 3d SPON2 S71 71 889 3d34_A(0.0926) Cluster-exclusive L:1 0.0926 1 1 ucec:1 ENST00000290902 5 3d SPON2 F97 97 889 3d34_A(0.0926) Cluster-exclusive I:1 0.0926 1 1 kirp:1 ENST00000290902 5 3d SPON2 E99 99 889 3d34_A(0.0926) Cluster-exclusive K:1 0.0926 1 1 thca:1 ENST00000290902 5 3d SPON2 R100 100 889 3d34_A(0.0926) Cluster-exclusive S:1 0.0926 1 1 luad:1 ENST00000290902 5 3d SPON2 E102 102 889 3d34_A(0.0926) Cluster-exclusive Q:1|K:1 0.0926 2 2 thca:1|ucs:1 ENST00000290902 5 3d IRF3 V229 229 891 3a77_C(0.0927);3a77_B(0.099) Cluster-exclusive G:1 0.0927 1 1 brca:1 ENST00000309877 7 3d IRF3 S231 231 891 3a77_C(0.0927);3a77_B(0.099) Cluster-exclusive F:1 0.0927 1 1 skcm:1 ENST00000309877 7 3d IRF3 T244 244 891 3a77_C(0.0927);3a77_B(0.099) Cluster-exclusive R:1 0.0927 1 1 lusc:1 ENST00000309877 7 3d IRF3 L268 268 891 3a77_C(0.0927);3a77_B(0.099) Cluster-exclusive M:1 0.0927 1 1 ucec:1 ENST00000309877 7 3d IRF3 G270 270 891 3a77_C(0.0927);3a77_B(0.099) Cluster-exclusive W:1 0.0927 1 1 prad:1 ENST00000309877 7 3d CASP7 R87 87 894 1k86_B(0.0932);3r5k_A(0.0965);4jr1_A(0.0956);4hqr_B(0.0933);1kmc_A(0.0975);1kmc_B(0.0977);1i4o_A(0.0987);4jr1_B(0.0941);3r5k_B(0.0928) Cluster-exclusive Q:1 0.0928 1 1 coadread:1 ENST00000345633 4 3d SRP9 Y18 18 895 4uyk_A(0.0928) Cluster-exclusive 0.0928 1 ENST00000304786 7 3d ESYT2 D825 825 896 2dmg_A(0.0934) Cluster-exclusive Y:1 0.0934 1 1 luad:1 ENST00000251527 5 3d ESYT2 T841 841 896 2dmg_A(0.0934) Cluster-exclusive M:1 0.0934 1 1 coadread:1 ENST00000251527 5 3d ESYT2 V844 844 896 2dmg_A(0.0934) Cluster-exclusive I:1 0.0934 1 1 ucec:1 ENST00000251527 5 3d ESYT2 N848 848 896 2dmg_A(0.0934) Cluster-exclusive S:1 0.0934 1 1 coadread:1 ENST00000251527 5 3d ESYT2 G850 850 896 2dmg_A(0.0934) Cluster-exclusive R:1 0.0934 1 1 hnsc:1 ENST00000251527 5 3d RAB30 T23 23 897 2ew1_A(0.0935) Cluster-exclusive S:1|M:1 0.0935 2 2 skcm:1|lusc:1 ENST00000260056 2 3d RAB30 R27 27 897 2ew1_A(0.0935) Cluster-exclusive G:1 0.0935 1 1 brca:1 ENST00000260056 2 3d RAB30 F34 34 897 2ew1_A(0.0935) Cluster-exclusive S:1 0.0935 1 1 prad:1 ENST00000260056 2 3d RAB30 P35 35 897 2ew1_A(0.0935) Cluster-exclusive S:1 0.0935 1 1 cscc:1 ENST00000260056 2 3d RAB30 P36 36 897 2ew1_A(0.0935) Cluster-exclusive L:1 0.0935 1 1 luad:1 ENST00000260056 2 3d RAB30 Q38 38 897 2ew1_A(0.0935) Cluster-exclusive E:1 0.0935 1 1 luad:1 ENST00000260056 2 3d KCNH5 L50 50 900 3gqc_B(0.0941) Cluster-exclusive P:1 0.0941 1 1 ov:1 ENST00000322893 7 3d KEAP1 F139 139 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive L:1 0.0942 1 1 luad:1 ENST00000171111 5 3d KEAP1 I145 145 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive F:2 0.0942 2 2 hnsc:1|luad:1 ENST00000171111 5 3d KEAP1 V155 155 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive A:1|F:2 0.0942 3 2 lusc:2|luad:1 ENST00000171111 5 3d KEAP1 A159 159 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive P:1|S:1 0.0942 2 1 luad:2 ENST00000171111 5 3d KEAP1 D165 165 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive N:2 0.0942 2 2 brca:1|coadread:1 ENST00000171111 5 3d KEAP1 V167 167 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive F:1 0.0942 1 1 lusc:1 ENST00000171111 5 3d KEAP1 R169 169 901 4cxi_A(0.0974);4cxt_A(0.0942) Cluster-exclusive C:2 0.0942 2 2 hnsc:1|ucec:1 ENST00000171111 5 3d RBMS3 L147 147 902 1x5o_A(0.0942) Cluster-exclusive I:1 0.0942 1 1 stad:1 ENST00000383767 2 3d RBMS3 S150 150 902 1x5o_A(0.0942) Cluster-exclusive Y:3 0.0942 3 3 coadread:1|ucec:1|cesc:1 ENST00000383767 2 3d RBMS3 M151 151 902 1x5o_A(0.0942) Cluster-exclusive R:1|V:1 0.0942 2 2 paad:1|hnsc:1 ENST00000383767 2 3d RBMS3 E155 155 902 1x5o_A(0.0942) Cluster-exclusive Q:1|K:1 0.0942 2 2 stad:1|skcm:1 ENST00000383767 2 3d CDK6 C207 207 903 1jow_B(0.0942) Cluster-exclusive F:1 0.0942 1 1 luad:1 ENST00000265734 4 3d CDK6 L218 218 903 1jow_B(0.0942) Cluster-exclusive I:1 0.0942 1 1 ucec:1 ENST00000265734 4 3d CDK6 R220 220 903 1jow_B(0.0942) Cluster-exclusive C:2 0.0942 2 2 coadread:1|kich:1 ENST00000265734 4 3d CDK6 V234 234 903 1jow_B(0.0942) Cluster-exclusive M:1 0.0942 1 1 stad:1 ENST00000265734 4 3d CDK6 F265 265 903 1jow_B(0.0942) Cluster-exclusive I:1 0.0942 1 1 ucec:1 ENST00000265734 4 3d MECOM P258 258 904 4fxy_P(0.0942) Cluster-exclusive S:2 0.0942 2 1 skcm:2 ENST00000468789 1 3d MECOM G259 259 904 4fxy_P(0.0942) Cluster-exclusive A:1 0.0942 1 1 brca:1 ENST00000468789 1 3d MECOM T260 260 904 4fxy_P(0.0942) Cluster-exclusive I:1 0.0942 1 1 lihc:1 ENST00000468789 1 3d MECOM M263 263 904 4fxy_P(0.0942) Cluster-exclusive I:1 0.0942 1 1 luad:1 ENST00000468789 1 3d MECOM D264 264 904 4fxy_P(0.0942) Cluster-exclusive Y:1 0.0942 1 1 blca:1 ENST00000468789 1 3d ITGAM G223 223 906 4m76_B(0.0943) Cluster-exclusive W:1 0.0943 1 1 luad:1 ENST00000287497 8 3d ITGAM D264 264 906 4m76_B(0.0943) Cluster-exclusive N:1 0.0943 1 1 skcm:1 ENST00000287497 8 3d SLFNL1 V371 371 908 2j0a_A(0.0944) Cluster-exclusive G:1 0.0944 1 1 brca:1 ENST00000302946 8 3d SLFNL1 G374 374 908 2j0a_A(0.0944) Cluster-exclusive D:1 0.0944 1 1 cesc:1 ENST00000302946 8 3d SLFNL1 K379 379 908 2j0a_A(0.0944) Cluster-exclusive M:1 0.0944 1 1 lihc:1 ENST00000302946 8 3d SLFNL1 E386 386 908 2j0a_A(0.0944) Cluster-exclusive K:1 0.0944 1 1 cscc:1 ENST00000302946 8 3d H3C2 V102 102 910 1hio_C(0.0945) Cluster-exclusive E:1 0.0945 1 1 mmyl:1 ENST00000244661 2 3d H3C2 L104 104 910 1hio_C(0.0945) Cluster-exclusive F:1 0.0945 1 1 brca:1 ENST00000244661 2 3d H3C2 F105 105 910 1hio_C(0.0945) Cluster-exclusive L:2 0.0945 2 1 coadread:2 ENST00000244661 2 3d H3C2 E106 106 910 1hio_C(0.0945) Cluster-exclusive K:3 0.0945 3 3 hnsc:1|cscc:1|luad:1 ENST00000244661 2 3d TNFSF18 L118 118 911 2r32_A(0.0947) Cluster-exclusive V:1 0.0947 1 1 ov:1 ENST00000404377 3 3d TNFSF18 I119 119 911 2r32_A(0.0947) Cluster-exclusive F:1 0.0947 1 1 skcm:1 ENST00000404377 3 3d TNFSF18 G159 159 911 2r32_A(0.0947) Cluster-exclusive E:2 0.0947 2 1 skcm:2 ENST00000404377 3 3d TNFSF18 G160 160 911 2r32_A(0.0947) Cluster-exclusive E:1 0.0947 1 1 skcm:1 ENST00000404377 3 3d TNFSF18 I170 170 911 2r32_A(0.0947) Cluster-exclusive T:1 0.0947 1 1 luad:1 ENST00000404377 3 3d TNFSF18 W187 187 911 2r32_A(0.0947) Cluster-exclusive C:1 0.0947 1 1 luad:1 ENST00000404377 3 3d RNF7 A60 60 912 2ecl_A(0.0948) Cluster-exclusive V:1 0.0948 1 1 blca:1 ENST00000273480 3 3d RNF7 C61 61 912 2ecl_A(0.0948) Cluster-exclusive S:1 0.0948 1 1 paad:1 ENST00000273480 3 3d RNF7 L62 62 912 2ecl_A(0.0948) Cluster-exclusive R:2 0.0948 2 2 thca:1|skcm:1 ENST00000273480 3 3d RNF7 A66 66 912 2ecl_A(0.0948) Cluster-exclusive T:1|V:1 0.0948 2 1 coadread:2 ENST00000273480 3 3d RNF7 Q70 70 912 2ecl_A(0.0948) Cluster-exclusive R:1 0.0948 1 1 coadread:1 ENST00000273480 3 3d GRM1 R661 661 913 4or2_A(0.0948) Cluster-exclusive H:1 0.0948 1 1 stad:1 ENST00000282753 1 3d GRM1 T719 719 913 4or2_A(0.0948) Cluster-exclusive A:1 0.0948 1 1 skcm:1 ENST00000282753 1 3d GRM1 L720 720 913 4or2_A(0.0948) Cluster-exclusive R:1 0.0948 1 1 lusm:1 ENST00000282753 1 3d GRM1 V721 721 913 4or2_A(0.0948) Cluster-exclusive L:1 0.0948 1 1 kirc:1 ENST00000282753 1 3d GRM1 T723 723 913 4or2_A(0.0948) Cluster-exclusive A:1 0.0948 1 1 esca:1 ENST00000282753 1 3d GRM1 P756 756 913 4or2_A(0.0948) Cluster-exclusive F:1 0.0948 1 1 cscc:1 ENST00000282753 1 3d PSMB3 Q61 61 914 3unb_K(0.0965);3une_K(0.0951) Cluster-exclusive H:1 0.0951 1 1 coadread:1 ENST00000619426 3d PSMB3 A64 64 914 3unb_K(0.0965);3une_K(0.0951) Cluster-exclusive V:1 0.0951 1 1 acc:1 ENST00000619426 3d PSMB3 R66 66 914 3unb_K(0.0965);3une_K(0.0951) Cluster-exclusive C:1|H:1 0.0951 2 2 stad:1|ucec:1 ENST00000619426 3d PSMB3 E75 75 914 3unb_K(0.0965);3une_K(0.0951) Cluster-exclusive V:1 0.0951 1 1 hnsc:1 ENST00000619426 3d ITGB1 L145 145 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive F:1 0.0955 1 1 cscc:1 ENST00000302278 3 3d ITGB1 L370 370 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive F:1 0.0955 1 1 hnsc:1 ENST00000302278 3 3d ITGB1 I371 371 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive M:1 0.0955 1 1 hnsc:1 ENST00000302278 3 3d LDLRAP1 S67 67 916 1eqf_A(0.0955) Cluster-exclusive L:1 0.0955 1 1 brca:1 ENST00000374338 4 3d LDLRAP1 A69 69 916 1eqf_A(0.0955) Cluster-exclusive T:1 0.0955 1 1 gbm:1 ENST00000374338 4 3d LDLRAP1 A70 70 916 1eqf_A(0.0955) Cluster-exclusive T:1 0.0955 1 1 stad:1 ENST00000374338 4 3d SMAD3 Y237 237 917 1dev_A(0.0959) Cluster-exclusive C:1 0.0959 1 1 coadread:1 ENST00000327367 4 3d SMAD3 E239 239 917 1dev_A(0.0959) Cluster-exclusive K:1 0.0959 1 1 coadread:1 ENST00000327367 4 3d SMAD3 R243 243 917 1dev_A(0.0959) Cluster-exclusive C:1 0.0959 1 1 luad:1 ENST00000327367 4 3d SMAD3 V244 244 917 1dev_A(0.0959) Cluster-exclusive I:1 0.0959 1 1 blca:1 ENST00000327367 4 3d SMAD3 N276 276 917 1dev_A(0.0959) Cluster-exclusive I:1 0.0959 1 1 coadread:1 ENST00000327367 4 3d SMAD3 R287 287 917 1dev_A(0.0959) Cluster-exclusive W:2 0.0959 2 2 paad:1|coadread:1 ENST00000327367 4 3d SMAD3 P393 393 917 1dev_A(0.0959) Cluster-exclusive T:1|L:1 0.0959 2 2 coadread:1|skcm:1 ENST00000327367 4 3d SMAD3 C394 394 917 1dev_A(0.0959) Cluster-exclusive F:1 0.0959 1 1 coadread:1 ENST00000327367 4 3d EPS15L1 P723 723 918 1qx7_A(0.0991);1qx7_B(0.0963) Cluster-exclusive L:2 0.0963 2 1 skcm:2 ENST00000248070 6 3d EPS15L1 L727 727 918 1qx7_A(0.0991);1qx7_B(0.0963) Cluster-exclusive I:1 0.0963 1 1 ucec:1 ENST00000248070 6 3d EPS15L1 P729 729 918 1qx7_A(0.0991);1qx7_B(0.0963) Cluster-exclusive S:1 0.0963 1 1 ucec:1 ENST00000248070 6 3d EPS15L1 G731 731 918 1qx7_A(0.0991);1qx7_B(0.0963) Cluster-exclusive A:1 0.0963 1 1 ov:1 ENST00000248070 6 3d VHL P86 86 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive L:1 0.0964 1 1 kirc:1 ENST00000256474 2 3d VHL W88 88 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive R:1|L:1 0.0964 2 1 kirc:2 ENST00000256474 2 3d VHL L89 89 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive P:1|H:3 0.0964 4 1 kirc:4 ENST00000256474 2 3d VHL S111 111 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive N:4 0.0964 4 1 kirc:4 ENST00000256474 2 3d VHL H115 115 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive Y:1|N:2 0.0964 3 1 kirc:3 ENST00000256474 2 3d VHL W117 117 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive C:1|L:1 0.0964 2 2 paad:1|kirc:1 ENST00000256474 2 3d VHL L135 135 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive F:2 0.0964 2 1 kirc:2 ENST00000256474 2 3d VHL F136 136 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Cluster-exclusive V:1|Y:1 0.0964 2 2 skcm:1|kirc:1 ENST00000256474 2 3d CIAO1 S169 169 920 3fm0_A(0.0967) Cluster-exclusive C:1 0.0967 1 1 stad:1 ENST00000488633 1 3d CIAO1 D171 171 920 3fm0_A(0.0967) Cluster-exclusive H:1 0.0967 1 1 brca:1 ENST00000488633 1 3d CIAO1 T173 173 920 3fm0_A(0.0967) Cluster-exclusive S:1 0.0967 1 1 cscc:1 ENST00000488633 1 3d CIAO1 T189 189 920 3fm0_A(0.0967) Cluster-exclusive I:1 0.0967 1 1 dlbc:1 ENST00000488633 1 3d CIAO1 L190 190 920 3fm0_A(0.0967) Cluster-exclusive I:1 0.0967 1 1 lihc:1 ENST00000488633 1 3d CIAO1 V197 197 920 3fm0_A(0.0967) Cluster-exclusive L:1 0.0967 1 1 skcm:1 ENST00000488633 1 3d ZNF572 C165 165 921 2ija_A(0.0968) Cluster-exclusive Y:1 0.0968 1 1 stad:1 ENST00000319286 5 3d ZNF572 C193 193 921 2ija_A(0.0968) Cluster-exclusive Y:1 0.0968 1 1 ucec:1 ENST00000319286 5 3d ZNF572 I204 204 921 2ija_A(0.0968) Cluster-exclusive M:1 0.0968 1 1 ucs:1 ENST00000319286 5 3d ZNF572 E207 207 921 2ija_A(0.0968) Cluster-exclusive Q:1 0.0968 1 1 cesc:1 ENST00000319286 5 3d ZNF572 R208 208 921 2ija_A(0.0968) Cluster-exclusive I:2 0.0968 2 1 ucec:2 ENST00000319286 5 3d ZNF572 T209 209 921 2ija_A(0.0968) Cluster-exclusive P:1 0.0968 1 1 esca:1 ENST00000319286 5 3d PACSIN1 R389 389 923 2x3w_D(0.097) Cluster-exclusive C:1|H:1 0.097 2 2 brca:1|skcm:1 ENST00000244458 2 3d PACSIN1 V390 390 923 2x3w_D(0.097) Cluster-exclusive M:1 0.097 1 1 stad:1 ENST00000244458 2 3d PACSIN1 G409 409 923 2x3w_D(0.097) Cluster-exclusive R:1 0.097 1 1 luad:1 ENST00000244458 2 3d PACSIN1 E411 411 923 2x3w_D(0.097) Cluster-exclusive K:1 0.097 1 1 ucec:1 ENST00000244458 2 3d FLNB D130 130 925 3fer_A(0.0979);3fer_B(0.0971) Cluster-exclusive H:1 0.0971 1 1 ov:1 ENST00000295956 4 3d FLNB G132 132 925 3fer_A(0.0979);3fer_B(0.0971) Cluster-exclusive V:1 0.0971 1 1 cesc:1 ENST00000295956 4 3d FLNB R144 144 925 3fer_A(0.0979);3fer_B(0.0971) Cluster-exclusive K:1 0.0971 1 1 skcm:1 ENST00000295956 4 3d FLNB W148 148 925 3fer_A(0.0979);3fer_B(0.0971) Cluster-exclusive G:1 0.0971 1 1 brca:1 ENST00000295956 4 3d FLNB P238 238 925 3fer_A(0.0979);3fer_B(0.0971) Cluster-exclusive S:1 0.0971 1 1 skcm:1 ENST00000295956 4 3d DDX3X Y525 525 926 2i4i_A(0.0972) Cluster-exclusive C:1 0.0972 1 1 lihc:1 ENST00000399959 2 3d DDX3X H527 527 926 2i4i_A(0.0972) Cluster-exclusive Y:1 0.0972 1 1 mbl:1 ENST00000399959 2 3d DDX3X R528 528 926 2i4i_A(0.0972) Cluster-exclusive C:3|H:2 0.0972 5 4 hnsc:1|mbl:1|skcm:1|ucec:2 ENST00000399959 2 3d DDX3X I529 529 926 2i4i_A(0.0972) Cluster-exclusive L:1 0.0972 1 1 skcm:1 ENST00000399959 2 3d DDX3X G530 530 926 2i4i_A(0.0972) Cluster-exclusive A:1 0.0972 1 1 mbl:1 ENST00000399959 2 3d DDX3X T532 532 926 2i4i_A(0.0972) Cluster-exclusive A:1|M:1 0.0972 2 2 skcm:1|cesc:1 ENST00000399959 2 3d DDX3X R534 534 926 2i4i_A(0.0972) Cluster-exclusive S:2|C:1|H:1 0.0972 4 2 stad:1|mbl:3 ENST00000399959 2 3d RBBP7 F367 367 928 2xu7_A(0.0972) Cluster-exclusive C:1 0.0972 1 1 coadread:1 ENST00000380087 2 3d H3C3 A30 30 929 1eqz_C(0.0973) Hotspot-linked P:1 0.0973 1 1 brca:1 ENST00000540144 1 3d H3C3 P31 31 929 1eqz_C(0.0973) Hotspot-linked S:1|L:2 0.0973 3 2 skcm:1|luad:2 ENST00000540144 1 3d H3C3 K37 37 929 1eqz_C(0.0973) Hotspot M:5 0.0973 5 2 hnsc:4|skcm:1 ENST00000540144 1 3d H3C3 P39 39 929 1eqz_C(0.0973) Hotspot-linked H:1 0.0973 1 1 ucs:1 ENST00000540144 1 3d H3C3 R41 41 929 1eqz_C(0.0973) Hotspot-linked C:2 0.0973 2 2 brca:1|luad:1 ENST00000540144 1 3d H2BC10 E77 77 930 3an2_D(0.0975) Cluster-exclusive Q:1|K:4 0.0975 5 4 blca:1|ucec:1|cesc:1|luad:2 ENST00000377733 2 3d H2BC10 R80 80 930 3an2_D(0.0975) Cluster-exclusive C:1|S:2 0.0975 3 2 ov:1|skcm:2 ENST00000377733 2 3d H2BC10 T89 89 930 3an2_D(0.0975) Cluster-exclusive N:1 0.0975 1 1 blca:1 ENST00000377733 2 3d H2BC10 E94 94 930 3an2_D(0.0975) Cluster-exclusive Q:1|D:1 0.0975 2 2 lusc:1|luad:1 ENST00000377733 2 3d CFHR3 M38 38 931 2ic4_A(0.0976) Cluster-exclusive I:1 0.0976 1 1 blca:1 ENST00000367425 4 3d CFHR3 R39 39 931 2ic4_A(0.0976) Cluster-exclusive C:1 0.0976 1 1 stad:1 ENST00000367425 4 3d CFHR3 R40 40 931 2ic4_A(0.0976) Cluster-exclusive T:1|K:1 0.0976 2 2 stad:1|luad:1 ENST00000367425 4 3d SNRPD3 V5 5 932 3pgw_Z(0.0976) Cluster-exclusive M:1 0.0976 1 1 stad:1 ENST00000215829 3 3d SNRPD3 P6 6 932 3pgw_Z(0.0976) Cluster-exclusive S:2 0.0976 2 2 prad:1|lusc:1 ENST00000215829 3 3d SOX9 H165 165 933 4euw_A(0.0977) Cluster-exclusive R:1 0.0977 1 1 stad:1 ENST00000245479 2 3d SOX9 K166 166 933 4euw_A(0.0977) Cluster-exclusive N:1 0.0977 1 1 hnsc:1 ENST00000245479 2 3d SOX9 K167 167 933 4euw_A(0.0977) Cluster-exclusive T:1 0.0977 1 1 luad:1 ENST00000245479 2 3d SOX9 D168 168 933 4euw_A(0.0977) Cluster-exclusive G:1 0.0977 1 1 coadread:1 ENST00000245479 2 3d SOX9 Y172 172 933 4euw_A(0.0977) Cluster-exclusive H:1 0.0977 1 1 coadread:1 ENST00000245479 2 3d ESYT2 N531 531 934 4gl7_A(0.0978) Cluster-exclusive T:1|H:1 0.0978 2 2 coadread:1|lymbc:1 ENST00000251527 5 3d ESYT2 P532 532 934 4gl7_A(0.0978) Cluster-exclusive S:1 0.0978 1 1 cscc:1 ENST00000251527 5 3d ESYT2 S584 584 934 4gl7_A(0.0978) Cluster-exclusive F:1 0.0978 1 1 skcm:1 ENST00000251527 5 3d ESYT2 L588 588 934 4gl7_A(0.0978) Cluster-exclusive P:1 0.0978 1 1 coadread:1 ENST00000251527 5 3d ESYT2 L592 592 934 4gl7_A(0.0978) Cluster-exclusive I:1 0.0978 1 1 coadread:1 ENST00000251527 5 3d ESYT2 R606 606 934 4gl7_A(0.0978) Cluster-exclusive H:1 0.0978 1 1 coadread:1 ENST00000251527 5 3d H2BC6 R73 73 935 3ayw_D(0.0981) Cluster-exclusive H:2 0.0981 2 2 paad:1|hnsc:1 ENST00000356530 3 3d H2BC6 E77 77 935 3ayw_D(0.0981) Cluster-exclusive K:1 0.0981 1 1 stad:1 ENST00000356530 3 3d H2BC6 A78 78 935 3ayw_D(0.0981) Cluster-exclusive T:1 0.0981 1 1 blca:1 ENST00000356530 3 3d H2BC6 S79 79 935 3ayw_D(0.0981) Cluster-exclusive F:1 0.0981 1 1 skcm:1 ENST00000356530 3 3d H2BC6 G105 105 935 3ayw_D(0.0981) Cluster-exclusive R:1 0.0981 1 1 blca:1 ENST00000356530 3 3d WRN D971 971 936 1d3l_A(0.0987) Cluster-exclusive V:1 0.0987 1 1 skcm:1 ENST00000298139 5 3d WRN I972 972 936 1d3l_A(0.0987) Cluster-exclusive M:1 0.0987 1 1 ucs:1 ENST00000298139 5 3d WRN L973 973 936 1d3l_A(0.0987) Cluster-exclusive F:1 0.0987 1 1 luad:1 ENST00000298139 5 3d TP53 H178 178 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked Q:2|D:1|N:1 0.099 4 4 kich:1|gbm:1|ov:1|ucec:1 ENST00000269305 4 3d TP53 R181 181 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked P:2|C:2|H:4 0.099 8 8 paad:1|coadread:1|lusm:1|ucs:1|skcm:1|ov:1|lgg:1|luad:1 ENST00000269305 4 3d CD81 E152 152 939 3kqg_B(0.099) Cluster-exclusive K:1 0.099 1 1 prad:1 ENST00000263645 5 3d CD81 C157 157 939 3kqg_B(0.099) Cluster-exclusive F:1 0.099 1 1 kirp:1 ENST00000263645 5 3d CD81 S160 160 939 3kqg_B(0.099) Cluster-exclusive I:1 0.099 1 1 stad:1 ENST00000263645 5 3d RANBP6 D437 437 940 1ocr_A(0.0991) Cluster-exclusive Y:2|N:1 0.0991 3 3 paad:1|coadread:1|ucec:1 ENST00000259569 5 3d RANBP6 L454 454 940 1ocr_A(0.0991) Cluster-exclusive M:1 0.0991 1 1 gbm:1 ENST00000259569 5 3d RANBP6 L455 455 940 1ocr_A(0.0991) Cluster-exclusive S:1 0.0991 1 1 coadread:1 ENST00000259569 5 3d RANBP6 R456 456 940 1ocr_A(0.0991) Cluster-exclusive C:1 0.0991 1 1 hnsc:1 ENST00000259569 5 3d RANBP6 T457 457 940 1ocr_A(0.0991) Cluster-exclusive I:1 0.0991 1 1 coadread:1 ENST00000259569 5 3d RPRD1B R198 198 941 4nad_B(0.0992) Cluster-exclusive P:1 0.0992 1 1 lihc:1 ENST00000373433 4 3d RPRD1B L236 236 941 4nad_B(0.0992) Cluster-exclusive F:1 0.0992 1 1 mmyl:1 ENST00000373433 4 3d RPRD1B L237 237 941 4nad_B(0.0992) Cluster-exclusive V:1 0.0992 1 1 dlbc:1 ENST00000373433 4 3d RPRD1B Y240 240 941 4nad_B(0.0992) Cluster-exclusive C:1 0.0992 1 1 mmyl:1 ENST00000373433 4 3d RPRD1B R243 243 941 4nad_B(0.0992) Cluster-exclusive L:1 0.0992 1 1 luad:1 ENST00000373433 4 3d RHOA G62 62 942 1ow3_B(0.0995) Cluster-exclusive R:1|E:2 0.0995 3 2 stad:2|hnsc:1 ENST00000418115 1 3d RHOA Q63 63 942 1ow3_B(0.0995) Cluster-exclusive K:1 0.0995 1 1 blca:1 ENST00000418115 1 3d RHOA Y66 66 942 1ow3_B(0.0995) Cluster-exclusive N:1 0.0995 1 1 paad:1 ENST00000418115 1 3d RHOA R70 70 942 1ow3_B(0.0995) Cluster-exclusive S:1 0.0995 1 1 luad:1 ENST00000418115 1 3d INHBA N374 374 943 2arp_A(0.0998) Cluster-exclusive T:1 0.0998 1 1 stad:1 ENST00000242208 4 3d INHBA R377 377 943 2arp_A(0.0998) Cluster-exclusive C:2|H:4 0.0998 6 5 coadread:2|gbm:1|ucs:1|skcm:1|ucec:1 ENST00000242208 4 3d INHBA R379 379 943 2arp_A(0.0998) Cluster-exclusive Q:1|W:2 0.0998 3 3 brca:1|coadread:1|stad:1 ENST00000242208 4 3d INHBA H381 381 943 2arp_A(0.0998) Cluster-exclusive Y:1 0.0998 1 1 lusm:1 ENST00000242208 4 3d INHBA A385 385 943 2arp_A(0.0998) Cluster-exclusive S:1 0.0998 1 1 coadread:1 ENST00000242208 4 3d INHBA L387 387 943 2arp_A(0.0998) Cluster-exclusive F:1 0.0998 1 1 skcm:1 ENST00000242208 4 3d PTEN A34 34 2 1d5r_A(0.0) Hotspot-linked V:1 0 1 1 ucec:1 ENST00000371953 3 3d PTEN M35 35 2 1d5r_A(0.0) Hotspot-linked I:1 0 1 1 luad:1 ENST00000371953 3 3d PTEN H123 123 2 1d5r_A(0.0) Hotspot-linked D:2|Y:3|L:1 0 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 2 1d5r_A(0.0) Hotspot-linked R:1|S:1|G:1 0 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN G127 127 2 1d5r_A(0.0) Hotspot-linked R:3|E:1|V:1 0 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN T131 131 2 1d5r_A(0.0) Hotspot-linked A:1 0 1 1 gbm:1 ENST00000371953 3 3d PTPN11 A72 72 4 4dgp_A(0.0) Hotspot T:3|D:2|V:2 0 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 4 4dgp_A(0.0) Hotspot A:2|G:1|K:4 0 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 Q506 506 4 4dgp_A(0.0) Hotspot-linked P:1 0 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 4 4dgp_A(0.0) Hotspot-linked K:2 0 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 4 4dgp_A(0.0) Hotspot E:1|H:3|L:3 0 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d H3C10 A2 2 7 3uii_P(0.0);3uik_P(0.0);3uii_Q(0.0);3uik_Q(0.0);3uef_D(0.0) Cluster-exclusive S:1|V:1|G:1 0 3 3 acc:1|brca:1|mmyl:1 ENST00000369163 2 3d H3C10 T4 4 7 3uii_P(0.0);3uik_P(0.0);3uii_Q(0.0);3uik_Q(0.0);3uef_D(0.0) Cluster-exclusive A:1 0 1 1 lusm:1 ENST00000369163 2 3d H3C10 K5 5 7 3uii_P(0.0);3uik_P(0.0);3uii_Q(0.0);3uik_Q(0.0);3uef_D(0.0) Cluster-exclusive M:1 0 1 1 hnsc:1 ENST00000369163 2 3d H4C11 R4 4 11 4m38_F(0.0) Cluster-exclusive G:1 0 1 1 thca:1 ENST00000355057 1 3d H4C11 G5 5 11 4m38_F(0.0) Cluster-exclusive D:1 0 1 1 lihc:1 ENST00000355057 1 3d SPOP Y87 87 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot S:2|C:1|N:2 0.0001 5 1 prad:5 ENST00000347630 2 3d SPOP W131 131 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot R:1|S:1|C:1|G:4 0.0001 7 2 prad:6|ucec:1 ENST00000347630 2 3d SPOP F133 133 13 3ivb_A(0.0059);3hqm_B(0.0055);3hqi_B(1.0E-4);3hqm_A(0.0035);3hql_B(0.0058);3hql_A(0.0048);3hsv_A(0.0041);3hsv_B(0.0065);3hu6_A(4.0E-4);3hu6_B(1.0E-4);3ivq_B(0.0051);4o1v_A(0.004);3ivq_A(0.0043);3hqi_A(2.0E-4);3hqh_A(0.0059);3ivv_A(0.0052) Hotspot S:3|C:4|V:4|I:2|L:9 0.0001 22 1 prad:22 ENST00000347630 2 3d PTPN11 F71 71 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot-linked L:3 0.0001 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot T:3|D:2|V:2 0.0001 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot A:2|G:1|K:4 0.0001 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 I282 282 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot-linked M:1 0.0001 1 1 gbm:1 ENST00000351677 2 3d PTPN11 Q506 506 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot-linked P:1 0.0001 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot-linked K:2 0.0001 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 14 4dgp_A(1.0E-4);4h1o_A(3.0E-4);4gwf_B(2.0E-4);4gwf_A(1.0E-4);2shp_A(5.0E-4);4dgx_A(3.0E-4) Hotspot E:1|H:3|L:3 0.0001 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d PTEN D24 24 15 1d5r_A(1.0E-4) Cluster-exclusive E:1|V:1|G:1|H:1|N:1 0.0001 5 4 brca:1|stad:2|ucs:1|ucec:1 ENST00000371953 3 3d PTEN L25 25 15 1d5r_A(1.0E-4) Cluster-exclusive V:1|F:2 0.0001 3 2 gbm:2|lgg:1 ENST00000371953 3 3d PTEN I33 33 15 1d5r_A(1.0E-4) Cluster-exclusive S:1 0.0001 1 1 ucec:1 ENST00000371953 3 3d PTEN A34 34 15 1d5r_A(1.0E-4) Hotspot-linked V:1 0.0001 1 1 ucec:1 ENST00000371953 3 3d PTEN M35 35 15 1d5r_A(1.0E-4) Hotspot-linked I:1 0.0001 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 15 1d5r_A(1.0E-4) Hotspot-linked R:2|E:1 0.0001 3 1 gbm:3 ENST00000371953 3 3d PTEN P38 38 15 1d5r_A(1.0E-4) Cluster-exclusive S:3|F:1|L:1 0.0001 5 2 ucs:1|skcm:4 ENST00000371953 3 3d PTEN N48 48 15 1d5r_A(1.0E-4) Cluster-exclusive I:1|K:1 0.0001 2 2 brca:1|prad:1 ENST00000371953 3 3d PTEN A121 121 15 1d5r_A(1.0E-4) Cluster-exclusive T:1 0.0001 1 1 lgg:1 ENST00000371953 3 3d PTEN H123 123 15 1d5r_A(1.0E-4) Hotspot-linked D:2|Y:3|L:1 0.0001 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 15 1d5r_A(1.0E-4) Hotspot-linked R:1|S:1|G:1 0.0001 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN A126 126 15 1d5r_A(1.0E-4) Hotspot-linked S:1|D:2|V:1|G:1 0.0001 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G127 127 15 1d5r_A(1.0E-4) Hotspot-linked R:3|E:1|V:1 0.0001 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN T131 131 15 1d5r_A(1.0E-4) Hotspot-linked A:1 0.0001 1 1 gbm:1 ENST00000371953 3 3d PTEN R159 159 15 1d5r_A(1.0E-4) Hotspot-linked S:1|K:1 0.0001 2 1 gbm:2 ENST00000371953 3 3d PTEN D24 24 16 1d5r_A(1.0E-4) Cluster-exclusive E:1|V:1|G:1|H:1|N:1 0.0001 5 4 brca:1|stad:2|ucs:1|ucec:1 ENST00000371953 3 3d PTEN L25 25 16 1d5r_A(1.0E-4) Cluster-exclusive V:1|F:2 0.0001 3 2 gbm:2|lgg:1 ENST00000371953 3 3d PTEN A34 34 16 1d5r_A(1.0E-4) Hotspot-linked V:1 0.0001 1 1 ucec:1 ENST00000371953 3 3d PTEN M35 35 16 1d5r_A(1.0E-4) Hotspot-linked I:1 0.0001 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 16 1d5r_A(1.0E-4) Hotspot-linked R:2|E:1 0.0001 3 1 gbm:3 ENST00000371953 3 3d PTEN P38 38 16 1d5r_A(1.0E-4) Cluster-exclusive S:3|F:1|L:1 0.0001 5 2 ucs:1|skcm:4 ENST00000371953 3 3d PTEN N48 48 16 1d5r_A(1.0E-4) Cluster-exclusive I:1|K:1 0.0001 2 2 brca:1|prad:1 ENST00000371953 3 3d PTEN H123 123 16 1d5r_A(1.0E-4) Hotspot-linked D:2|Y:3|L:1 0.0001 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 16 1d5r_A(1.0E-4) Hotspot-linked R:1|S:1|G:1 0.0001 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN A126 126 16 1d5r_A(1.0E-4) Hotspot-linked S:1|D:2|V:1|G:1 0.0001 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G127 127 16 1d5r_A(1.0E-4) Hotspot-linked R:3|E:1|V:1 0.0001 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d ITGA1 Q303 303 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive E:1 0.0005 1 1 prad:1 ENST00000282588 6 3d ITGA1 R304 304 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive Q:1 0.0005 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive F:1 0.0005 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive S:1 0.0005 1 1 mcl:1 ENST00000282588 6 3d ITGA1 E333 333 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive G:1|K:1 0.0005 2 2 skcm:1|lihc:1 ENST00000282588 6 3d ITGA1 E336 336 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive K:1 0.0005 1 1 cscc:1 ENST00000282588 6 3d ITGA1 H338 338 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive P:1 0.0005 1 1 paad:1 ENST00000282588 6 3d ITGA1 F339 339 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive L:1 0.0005 1 1 coadread:1 ENST00000282588 6 3d ITGA1 R358 358 21 1qc5_B(7.0E-4);2b2x_A(6.0E-4);1qc5_A(7.0E-4);1mhp_A(6.0E-4);1mhp_B(0.0013);4a0q_A(5.0E-4);4a0q_B(7.0E-4);1ck4_A(0.0013);1qcy_A(5.0E-4);1pt6_A(0.0012);1ck4_B(8.0E-4) Cluster-exclusive S:1 0.0005 1 1 hnsc:1 ENST00000282588 6 3d TP53 R273 273 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot P:4|C:119|S:5|H:103|L:22 0.0011 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 C275 275 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot R:1|S:4|F:10|Y:15 0.0011 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d TP53 C277 277 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked F:5|G:1 0.0011 6 5 mmyl:1|blca:1|hnsc:1|ov:1|luad:2 ENST00000269305 4 3d TP53 P278 278 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot A:5|R:5|S:11|T:6|H:3|L:7 0.0011 37 13 brca:4|mmyl:1|paad:1|coadread:5|esca:2|hnsc:7|ov:5|lusc:4|lgg:1|skcm:2|ucec:1|cscc:2|luad:2 ENST00000269305 4 3d TP53 G279 279 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked R:1|E:4 0.0011 5 4 brca:1|blca:1|ov:1|cscc:2 ENST00000269305 4 3d TP53 R280 280 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot S:4|T:10|G:6|I:5|K:15 0.0011 40 17 brca:3|npc:1|esca:1|ucs:1|blca:7|hnsc:7|laml:1|ov:2|lihc:2|lusc:1|lgg:3|lusm:1|stad:1|skcm:2|cesc:1|luad:5|cscc:1 ENST00000269305 4 3d TP53 D281 281 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot P:1|A:1|E:4|V:4|G:1|H:2|Y:8|N:7 0.0011 28 16 brca:3|mmyl:1|paad:1|cll:1|ucs:1|blca:1|hnsc:1|ov:4|lihc:1|lusc:1|stad:1|gbm:3|nbl:1|ucec:1|kirc:1|luad:6 ENST00000269305 4 3d TP53 R282 282 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot P:1|Q:2|W:83|G:4 0.0011 90 19 paad:9|brca:1|coadread:21|esca:7|blca:1|hnsc:14|ov:6|lihc:1|lusc:2|lymbc:1|lgg:4|kich:1|prad:1|stad:9|gbm:5|skcm:2|ucec:1|cscc:1|luad:3 ENST00000269305 4 3d TP53 R283 283 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked P:7|H:1 0.0011 8 4 paad:1|hnsc:4|lusc:1|luad:2 ENST00000269305 4 3d TP53 T284 284 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked P:1 0.0011 1 1 lusc:1 ENST00000269305 4 3d TP53 E285 285 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot-linked V:2|K:20 0.0011 22 9 brca:4|npc:1|lusm:1|prad:1|stad:2|blca:7|hnsc:2|cesc:2|luad:2 ENST00000269305 4 3d TP53 E286 286 27 3exj_A(0.0011);2geq_B(0.0014) Hotspot A:1|Q:3|V:1|G:4|K:17 0.0011 26 12 brca:5|coadread:2|stad:3|esca:1|hnsc:2|laml:1|ov:1|skcm:2|lihc:2|lgg:1|cscc:2|luad:4 ENST00000269305 4 3d ZNF98 C492 492 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive F:1 0.0011 1 1 luad:1 ENST00000357774 5 3d ZNF98 E493 493 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive G:1 0.0011 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive Q:1 0.0011 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive A:1|D:1 0.0011 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive I:1 0.0011 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive T:1 0.0011 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive V:1 0.0011 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive T:1 0.0011 1 1 coadread:1 ENST00000357774 5 3d ZNF98 Q501 501 28 3brt_B(0.0011);3brt_D(0.0012);3brv_D(0.0017) Cluster-exclusive K:1 0.0011 1 1 npc:1 ENST00000357774 5 3d PTEN M35 35 30 1d5r_A(0.0013) Hotspot-linked I:1 0.0013 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 30 1d5r_A(0.0013) Hotspot-linked R:2|E:1 0.0013 3 1 gbm:3 ENST00000371953 3 3d PTEN L70 70 30 1d5r_A(0.0013) Hotspot-linked H:1 0.0013 1 1 gbm:1 ENST00000371953 3 3d PTEN H123 123 30 1d5r_A(0.0013) Hotspot-linked D:2|Y:3|L:1 0.0013 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 30 1d5r_A(0.0013) Hotspot-linked R:1|S:1|G:1 0.0013 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN K125 125 30 1d5r_A(0.0013) Hotspot-linked T:1|N:1 0.0013 2 2 coadread:1|kirc:1 ENST00000371953 3 3d PTEN A126 126 30 1d5r_A(0.0013) Hotspot-linked S:1|D:2|V:1|G:1 0.0013 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G127 127 30 1d5r_A(0.0013) Hotspot-linked R:3|E:1|V:1 0.0013 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN K128 128 30 1d5r_A(0.0013) Hotspot-linked Q:2|N:3 0.0013 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN R130 130 30 1d5r_A(0.0013) Hotspot P:3|Q:35|G:28|L:5 0.0013 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN T131 131 30 1d5r_A(0.0013) Hotspot-linked A:1 0.0013 1 1 gbm:1 ENST00000371953 3 3d BRAF G466 466 31 4wo5_A(0.0013) Hotspot A:1|E:6|V:10 0.0013 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 31 4wo5_A(0.0013) Hotspot-linked L:2 0.0013 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 31 4wo5_A(0.0013) Hotspot A:9|R:3|S:1|E:2|V:6 0.0013 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF G596 596 31 4wo5_A(0.0013) Hotspot R:2|S:1|D:1|V:1 0.0013 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d PTPN11 A72 72 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot T:3|D:2|V:2 0.0013 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 S502 502 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot-linked P:1|L:1 0.0013 2 2 gbm:1|laml:1 ENST00000351677 2 3d PTPN11 Q506 506 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot-linked P:1 0.0013 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot-linked K:2 0.0013 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 32 4dgp_A(0.0027);4h1o_A(0.0027);4gwf_B(0.0028);4gwf_A(0.0013);2shp_A(0.0044);4dgx_A(0.0028) Hotspot E:1|H:3|L:3 0.0013 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d BRAF G466 466 33 4dbn_B(0.0014) Hotspot A:1|E:6|V:10 0.0014 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF D594 594 33 4dbn_B(0.0014) Hotspot G:6|H:1|N:5 0.0014 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 33 4dbn_B(0.0014) Hotspot-linked L:1 0.0014 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 33 4dbn_B(0.0014) Hotspot R:2|S:1|D:1|V:1 0.0014 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 33 4dbn_B(0.0014) Hotspot Q:2|R:1|S:1 0.0014 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF K601 601 33 4dbn_B(0.0014) Hotspot T:1|E:12|N:2 0.0014 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PTPN11 A72 72 35 2shp_A(0.0016) Hotspot T:3|D:2|V:2 0.0016 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 T468 468 35 2shp_A(0.0016) Hotspot-linked M:5 0.0016 5 3 coadread:1|stad:2|skcm:2 ENST00000351677 2 3d PTPN11 Q506 506 35 2shp_A(0.0016) Hotspot-linked P:1 0.0016 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 35 2shp_A(0.0016) Hotspot-linked K:2 0.0016 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 35 2shp_A(0.0016) Hotspot E:1|H:3|L:3 0.0016 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d BRAF G464 464 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot-linked V:2 0.0017 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot A:1|E:6|V:10 0.0017 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot-linked L:2 0.0017 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot A:9|R:3|S:1|E:2|V:6 0.0017 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot-linked I:1 0.0017 1 1 paad:1 ENST00000288602 6 3d BRAF F595 595 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot-linked L:1 0.0017 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot R:2|S:1|D:1|V:1 0.0017 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot Q:2|R:1|S:1 0.0017 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF K601 601 36 4g9r_B(0.0017);1uwj_A(0.0021);4g9r_A(0.0026) Hotspot T:1|E:12|N:2 0.0017 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PPP2R1A P179 179 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot R:12|L:1 0.0023 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot-linked W:1 0.0023 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot Q:4|W:14|G:1 0.0023 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A Q217 217 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot-linked K:1 0.0023 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A S219 219 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot-linked L:3 0.0023 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 43 2pf4_B(0.0033);2pf4_A(0.0028);2nyl_A(0.0033);3dw8_D(0.0025);2npp_A(0.0023);3dw8_A(0.0025);2nym_A(0.0033);2nym_D(0.0031);2nyl_D(0.0037);2pkg_B(0.003);2npp_D(0.0038);2iae_A(0.0032);2pf4_C(0.003) Hotspot-linked M:1 0.0023 1 1 ucec:1 ENST00000322088 6 3d PTPN11 D61 61 45 1ayc_A(0.003);4je4_A(0.0025);3tl0_A(0.0025) Hotspot-linked Y:1|N:1 0.0025 2 2 laml:1|nbl:1 ENST00000351677 2 3d PTPN11 F71 71 45 1ayc_A(0.003);4je4_A(0.0025);3tl0_A(0.0025) Hotspot-linked L:3 0.0025 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 45 1ayc_A(0.003);4je4_A(0.0025);3tl0_A(0.0025) Hotspot T:3|D:2|V:2 0.0025 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 45 1ayc_A(0.003);4je4_A(0.0025);3tl0_A(0.0025) Hotspot A:2|G:1|K:4 0.0025 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d TP53 R273 273 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot P:4|C:119|S:5|H:103|L:22 0.0027 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 C275 275 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot R:1|S:4|F:10|Y:15 0.0027 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d TP53 A276 276 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked P:3|D:2|G:1 0.0027 6 6 brca:1|esca:1|hnsc:1|ov:1|lihc:1|luad:1 ENST00000269305 4 3d TP53 C277 277 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked F:5|G:1 0.0027 6 5 mmyl:1|blca:1|hnsc:1|ov:1|luad:2 ENST00000269305 4 3d TP53 P278 278 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot A:5|R:5|S:11|T:6|H:3|L:7 0.0027 37 13 brca:4|mmyl:1|paad:1|coadread:5|esca:2|hnsc:7|ov:5|lusc:4|lgg:1|skcm:2|ucec:1|cscc:2|luad:2 ENST00000269305 4 3d TP53 G279 279 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked R:1|E:4 0.0027 5 4 brca:1|blca:1|ov:1|cscc:2 ENST00000269305 4 3d TP53 R280 280 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot S:4|T:10|G:6|I:5|K:15 0.0027 40 17 brca:3|npc:1|esca:1|ucs:1|blca:7|hnsc:7|laml:1|ov:2|lihc:2|lusc:1|lgg:3|lusm:1|stad:1|skcm:2|cesc:1|luad:5|cscc:1 ENST00000269305 4 3d TP53 D281 281 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot P:1|A:1|E:4|V:4|G:1|H:2|Y:8|N:7 0.0027 28 16 brca:3|mmyl:1|paad:1|cll:1|ucs:1|blca:1|hnsc:1|ov:4|lihc:1|lusc:1|stad:1|gbm:3|nbl:1|ucec:1|kirc:1|luad:6 ENST00000269305 4 3d TP53 R282 282 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot P:1|Q:2|W:83|G:4 0.0027 90 19 paad:9|brca:1|coadread:21|esca:7|blca:1|hnsc:14|ov:6|lihc:1|lusc:2|lymbc:1|lgg:4|kich:1|prad:1|stad:9|gbm:5|skcm:2|ucec:1|cscc:1|luad:3 ENST00000269305 4 3d TP53 R283 283 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked P:7|H:1 0.0027 8 4 paad:1|hnsc:4|lusc:1|luad:2 ENST00000269305 4 3d TP53 T284 284 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked P:1 0.0027 1 1 lusc:1 ENST00000269305 4 3d TP53 E285 285 46 3exl_A(0.0027);3exj_B(0.0036) Hotspot-linked V:2|K:20 0.0027 22 9 brca:4|npc:1|lusm:1|prad:1|stad:2|blca:7|hnsc:2|cesc:2|luad:2 ENST00000269305 4 3d PPP2R1A P179 179 47 4i5n_D(0.0027) Hotspot R:12|L:1 0.0027 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 47 4i5n_D(0.0027) Hotspot-linked W:1 0.0027 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 47 4i5n_D(0.0027) Hotspot Q:4|W:14|G:1 0.0027 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A A185 185 47 4i5n_D(0.0027) Hotspot-linked T:1 0.0027 1 1 coadread:1 ENST00000322088 6 3d PPP2R1A S219 219 47 4i5n_D(0.0027) Hotspot-linked L:3 0.0027 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 47 4i5n_D(0.0027) Hotspot-linked M:1 0.0027 1 1 ucec:1 ENST00000322088 6 3d PTEN A34 34 50 1d5r_A(0.003) Hotspot-linked V:1 0.003 1 1 ucec:1 ENST00000371953 3 3d PTEN K128 128 50 1d5r_A(0.003) Hotspot-linked Q:2|N:3 0.003 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN T131 131 50 1d5r_A(0.003) Hotspot-linked A:1 0.003 1 1 gbm:1 ENST00000371953 3 3d PTEN G132 132 50 1d5r_A(0.003) Hotspot-linked S:2|D:4|V:1 0.003 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN I135 135 50 1d5r_A(0.003) Hotspot-linked K:1 0.003 1 1 brca:1 ENST00000371953 3 3d PTEN C136 136 50 1d5r_A(0.003) Hotspot R:4|F:2|Y:2 0.003 8 5 coadread:1|gbm:3|hnsc:1|skcm:1|ucec:2 ENST00000371953 3 3d PTEN Y155 155 50 1d5r_A(0.003) Hotspot-linked C:2 0.003 2 2 ucs:1|ucec:1 ENST00000371953 3 3d PTEN R159 159 50 1d5r_A(0.003) Hotspot-linked S:1|K:1 0.003 2 1 gbm:2 ENST00000371953 3 3d SPOP Y87 87 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot S:2|C:1|N:2 0.0031 5 1 prad:5 ENST00000347630 2 3d SPOP F102 102 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot C:2|V:2|L:1 0.0031 5 1 prad:5 ENST00000347630 2 3d SPOP F104 104 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked S:1|I:1 0.0031 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked V:4 0.0031 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP F133 133 51 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hql_B(0.0385);3hqm_A(0.0372);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot S:3|C:4|V:4|I:2|L:9 0.0031 22 1 prad:22 ENST00000347630 2 3d SPOP Y87 87 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot S:2|C:1|N:2 0.0031 5 1 prad:5 ENST00000347630 2 3d SPOP F104 104 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked S:1|I:1 0.0031 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP D130 130 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked H:1|N:1 0.0031 2 2 prad:1|cll:1 ENST00000347630 2 3d SPOP W131 131 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot R:1|S:1|C:1|G:4 0.0031 7 2 prad:6|ucec:1 ENST00000347630 2 3d SPOP F133 133 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot S:3|C:4|V:4|I:2|L:9 0.0031 22 1 prad:22 ENST00000347630 2 3d SPOP K134 134 52 3hqm_B(0.0415);3ivb_A(0.0398);3hqi_B(0.0035);3hqm_A(0.0372);3hql_B(0.0385);3hql_A(0.037);2cr2_A(0.0574);3hsv_A(0.0359);3hsv_B(0.0414);3hu6_A(0.0032);3hu6_B(0.0031);3ivq_B(0.035);4o1v_A(0.0415);3ivq_A(0.0373);3hqi_A(0.0034);3hqh_A(0.0423);3ivv_A(0.0376) Hotspot-linked N:1 0.0031 1 1 prad:1 ENST00000347630 2 3d CENPE R128 128 53 1t5c_A(0.0047);1t5c_B(0.0031) Cluster-exclusive C:1 0.0031 1 1 stad:1 ENST00000265148 3 3d CENPE V129 129 53 1t5c_A(0.0047);1t5c_B(0.0031) Cluster-exclusive A:1|L:1 0.0031 2 2 lihc:1|luad:1 ENST00000265148 3 3d CENPE S130 130 53 1t5c_A(0.0047);1t5c_B(0.0031) Cluster-exclusive F:1 0.0031 1 1 skcm:1 ENST00000265148 3 3d CENPE E170 170 53 1t5c_A(0.0047);1t5c_B(0.0031) Cluster-exclusive K:2 0.0031 2 2 brca:1|coadread:1 ENST00000265148 3 3d CENPE M209 209 53 1t5c_A(0.0047);1t5c_B(0.0031) Cluster-exclusive V:1 0.0031 1 1 lihc:1 ENST00000265148 3 3d KRAS G12 12 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0034 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot A:1|R:1|C:12|D:75|V:2 0.0034 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS A59 59 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked T:1|E:1|G:3 0.0034 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot D:1 0.0034 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0034 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked G:1|K:1 0.0034 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked K:2 0.0034 2 2 mmyl:1|pias:1 ENST00000311936 3 3d KRAS Y64 64 56 1nvv_R(0.0034);1xd2_B(0.0035) Hotspot-linked D:1|H:1|N:1 0.0034 3 2 mmyl:2|coadread:1 ENST00000311936 3 3d PTEN G129 129 57 1d5r_A(0.0034) Hotspot-linked R:1|E:2|V:2 0.0034 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN R130 130 57 1d5r_A(0.0034) Hotspot P:3|Q:35|G:28|L:5 0.0034 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN V166 166 57 1d5r_A(0.0034) Hotspot-linked I:1 0.0034 1 1 lihc:1 ENST00000371953 3 3d CDK4 K22 22 58 3g33_C(0.0407);2w99_B(0.0398);2w9z_B(0.0405);3g33_A(0.0411);2w96_B(0.0378);2w9f_B(0.0034) Hotspot Q:2|M:2 0.0034 4 2 mmyl:1|skcm:3 ENST00000257904 6 3d CDK4 A23 23 58 3g33_C(0.0407);2w99_B(0.0398);2w9z_B(0.0405);3g33_A(0.0411);2w96_B(0.0378);2w9f_B(0.0034) Hotspot-linked S:1 0.0034 1 1 luad:1 ENST00000257904 6 3d CDK4 R24 24 58 3g33_C(0.0407);2w99_B(0.0398);2w9z_B(0.0405);3g33_A(0.0411);2w96_B(0.0378);2w9f_B(0.0034) Hotspot C:2|S:1|H:2|L:5 0.0034 10 3 mmyl:1|skcm:6|luad:3 ENST00000257904 6 3d CDK4 F31 31 58 3g33_C(0.0407);2w99_B(0.0398);2w9z_B(0.0405);3g33_A(0.0411);2w96_B(0.0378);2w9f_B(0.0034) Hotspot-linked C:1 0.0034 1 1 prad:1 ENST00000257904 6 3d BRAF G466 466 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot A:1|E:6|V:10 0.004 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot-linked L:2 0.004 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot A:9|R:3|S:1|E:2|V:6 0.004 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF D594 594 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot G:6|H:1|N:5 0.004 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot-linked L:1 0.004 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot R:2|S:1|D:1|V:1 0.004 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 61 3d4q_B(0.0058);3d4q_A(0.0063);3ppj_A(0.0043);3ppk_A(0.004) Hotspot Q:2|R:1|S:1 0.004 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d KRAS A11 11 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked T:1 0.0042 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0042 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot A:1|R:1|C:12|D:75|V:2 0.0042 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS P34 34 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked L:1 0.0042 1 1 coadread:1 ENST00000311936 3 3d KRAS A59 59 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked T:1|E:1|G:3 0.0042 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot D:1 0.0042 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0042 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked G:1|K:1 0.0042 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked K:2 0.0042 2 2 mmyl:1|pias:1 ENST00000311936 3 3d KRAS Y64 64 65 1nvw_Q(0.0042);6q21_A(0.0051) Hotspot-linked D:1|H:1|N:1 0.0042 3 2 mmyl:2|coadread:1 ENST00000311936 3 3d BRAF G464 464 66 4h58_C(0.0042) Hotspot-linked V:2 0.0042 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 66 4h58_C(0.0042) Hotspot A:1|E:6|V:10 0.0042 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF F595 595 66 4h58_C(0.0042) Hotspot-linked L:1 0.0042 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 66 4h58_C(0.0042) Hotspot R:2|S:1|D:1|V:1 0.0042 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 66 4h58_C(0.0042) Hotspot Q:2|R:1|S:1 0.0042 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 66 4h58_C(0.0042) Hotspot R:4|E:509|K:32 0.0042 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 66 4h58_C(0.0042) Hotspot T:1|E:12|N:2 0.0042 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PPP2R1A P179 179 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot R:12|L:1 0.0042 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked W:1 0.0042 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot Q:4|W:14|G:1 0.0042 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A Q217 217 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked K:1 0.0042 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A S219 219 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked L:3 0.0042 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 67 3k7v_A(0.0042);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked M:1 0.0042 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A P179 179 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot R:12|L:1 0.0042 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked W:1 0.0042 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot Q:4|W:14|G:1 0.0042 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A A185 185 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked T:1 0.0042 1 1 coadread:1 ENST00000322088 6 3d PPP2R1A S219 219 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked L:3 0.0042 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 68 2ie4_A(0.0048);2pkg_A(0.0054);4i5l_A(0.0047);3fga_A(0.005);3k7v_A(0.0042);4i5l_D(0.0047);1b3u_B(0.005);4i5n_A(0.0056);1b3u_A(0.0044);2ie3_A(0.0066);3k7w_A(0.0054) Hotspot-linked M:1 0.0042 1 1 ucec:1 ENST00000322088 6 3d BRAF G466 466 70 4g9c_A(0.0043) Hotspot A:1|E:6|V:10 0.0043 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 70 4g9c_A(0.0043) Hotspot-linked L:2 0.0043 2 1 skcm:2 ENST00000288602 6 3d BRAF F595 595 70 4g9c_A(0.0043) Hotspot-linked L:1 0.0043 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 70 4g9c_A(0.0043) Hotspot R:2|S:1|D:1|V:1 0.0043 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 70 4g9c_A(0.0043) Hotspot Q:2|R:1|S:1 0.0043 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 70 4g9c_A(0.0043) Hotspot R:4|E:509|K:32 0.0043 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 70 4g9c_A(0.0043) Hotspot T:1|E:12|N:2 0.0043 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PTEN K128 128 72 1d5r_A(0.0045) Hotspot-linked Q:2|N:3 0.0045 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN G129 129 72 1d5r_A(0.0045) Hotspot-linked R:1|E:2|V:2 0.0045 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN G132 132 72 1d5r_A(0.0045) Hotspot-linked S:2|D:4|V:1 0.0045 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN C136 136 72 1d5r_A(0.0045) Hotspot R:4|F:2|Y:2 0.0045 8 5 coadread:1|gbm:3|hnsc:1|skcm:1|ucec:2 ENST00000371953 3 3d PTEN L152 152 72 1d5r_A(0.0045) Hotspot-linked P:1|R:1 0.0045 2 2 lusm:1|ucec:1 ENST00000371953 3 3d PTEN Y155 155 72 1d5r_A(0.0045) Hotspot-linked C:2 0.0045 2 2 ucs:1|ucec:1 ENST00000371953 3 3d PTEN G165 165 72 1d5r_A(0.0045) Hotspot-linked R:3|E:4 0.0045 7 5 coadread:1|lusm:1|mbl:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN V166 166 72 1d5r_A(0.0045) Hotspot-linked I:1 0.0045 1 1 lihc:1 ENST00000371953 3 3d PTEN T167 167 72 1d5r_A(0.0045) Hotspot-linked S:1 0.0045 1 1 gbm:1 ENST00000371953 3 3d PTEN Q171 171 72 1d5r_A(0.0045) Hotspot-linked K:1 0.0045 1 1 lusc:1 ENST00000371953 3 3d PTEN K128 128 75 1d5r_A(0.0048) Hotspot-linked Q:2|N:3 0.0048 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN G129 129 75 1d5r_A(0.0048) Hotspot-linked R:1|E:2|V:2 0.0048 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN R130 130 75 1d5r_A(0.0048) Hotspot P:3|Q:35|G:28|L:5 0.0048 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN T131 131 75 1d5r_A(0.0048) Hotspot-linked A:1 0.0048 1 1 gbm:1 ENST00000371953 3 3d PTEN G132 132 75 1d5r_A(0.0048) Hotspot-linked S:2|D:4|V:1 0.0048 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN M134 134 75 1d5r_A(0.0048) Hotspot-linked I:1 0.0048 1 1 ucec:1 ENST00000371953 3 3d PTEN I135 135 75 1d5r_A(0.0048) Hotspot-linked K:1 0.0048 1 1 brca:1 ENST00000371953 3 3d PTEN C136 136 75 1d5r_A(0.0048) Hotspot R:4|F:2|Y:2 0.0048 8 5 coadread:1|gbm:3|hnsc:1|skcm:1|ucec:2 ENST00000371953 3 3d PTEN Y155 155 75 1d5r_A(0.0048) Hotspot-linked C:2 0.0048 2 2 ucs:1|ucec:1 ENST00000371953 3 3d PTEN V166 166 75 1d5r_A(0.0048) Hotspot-linked I:1 0.0048 1 1 lihc:1 ENST00000371953 3 3d SYT14 S410 410 80 3hhc_B(0.0052) Cluster-exclusive Y:1 0.0052 1 1 ucec:1 ENST00000472886 1 3d SYT14 L411 411 80 3hhc_B(0.0052) Cluster-exclusive V:1 0.0052 1 1 brca:1 ENST00000472886 1 3d SYT14 E412 412 80 3hhc_B(0.0052) Cluster-exclusive Q:1|D:1 0.0052 2 2 esca:1|luad:1 ENST00000472886 1 3d SYT14 G414 414 80 3hhc_B(0.0052) Cluster-exclusive D:1 0.0052 1 1 cscc:1 ENST00000472886 1 3d SYT14 S415 415 80 3hhc_B(0.0052) Cluster-exclusive A:1 0.0052 1 1 ov:1 ENST00000472886 1 3d PTPN11 G60 60 82 4h1o_A(0.0054) Hotspot-linked V:1 0.0054 1 1 laml:1 ENST00000351677 2 3d PTPN11 A72 72 82 4h1o_A(0.0054) Hotspot T:3|D:2|V:2 0.0054 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 T468 468 82 4h1o_A(0.0054) Hotspot-linked M:5 0.0054 5 3 coadread:1|stad:2|skcm:2 ENST00000351677 2 3d PTPN11 T507 507 82 4h1o_A(0.0054) Hotspot-linked K:2 0.0054 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 82 4h1o_A(0.0054) Hotspot E:1|H:3|L:3 0.0054 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d PTPN11 R512 512 82 4h1o_A(0.0054) Hotspot-linked Q:1 0.0054 1 1 coadread:1 ENST00000351677 2 3d ZNF98 L362 362 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive F:1 0.0055 1 1 hnsc:1 ENST00000357774 5 3d ZNF98 S363 363 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive F:1 0.0055 1 1 skcm:1 ENST00000357774 5 3d ZNF98 H364 364 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive Y:1 0.0055 1 1 skcm:1 ENST00000357774 5 3d ZNF98 T366 366 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive A:1|N:1 0.0055 2 2 skcm:1|luad:1 ENST00000357774 5 3d ZNF98 K369 369 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive T:1 0.0055 1 1 stad:1 ENST00000357774 5 3d ZNF98 R370 370 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive I:3|K:1 0.0055 4 2 skcm:1|ucec:3 ENST00000357774 5 3d ZNF98 R398 398 83 1y6n_R(0.0057);1lqs_R(0.007);1lqs_S(0.0055);1j7v_R(0.0057) Cluster-exclusive I:1 0.0055 1 1 ucec:1 ENST00000357774 5 3d HRAS A11 11 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot-linked D:1 0.0058 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0058 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot R:11|C:2|S:1|D:2|V:9 0.0058 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS G60 60 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot-linked S:1 0.0058 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 84 1nvx_Q(0.0074);1nvw_Q(0.0089);2lwi_A(0.0166);3kud_A(0.0097);6q21_A(0.0065);1nvu_Q(0.0075);2lcf_A(0.0182);1iaq_C(0.0058) Hotspot R:19|H:2|K:10|L:9 0.0058 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d KRAS G12 12 85 1nvv_Q(0.0059) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0059 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 85 1nvv_Q(0.0059) Hotspot A:1|R:1|C:12|D:75|V:2 0.0059 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS P34 34 85 1nvv_Q(0.0059) Hotspot-linked L:1 0.0059 1 1 coadread:1 ENST00000311936 3 3d KRAS A59 59 85 1nvv_Q(0.0059) Hotspot-linked T:1|E:1|G:3 0.0059 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 85 1nvv_Q(0.0059) Hotspot D:1 0.0059 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 85 1nvv_Q(0.0059) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0059 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 85 1nvv_Q(0.0059) Hotspot-linked G:1|K:1 0.0059 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 85 1nvv_Q(0.0059) Hotspot-linked K:2 0.0059 2 2 mmyl:1|pias:1 ENST00000311936 3 3d HRAS G12 12 86 3rs4_A(0.0077);4nym_Q(0.0075);3rs2_A(0.0089);2cl6_X(0.0086);3rs3_A(0.0078);3rs7_A(0.0079);3v4f_A(0.0061);3l8y_A(0.0095);4dls_A(0.0081);3rrz_A(0.0105);4dlv_A(0.0097);1nvv_Q(0.0079);4dlx_A(0.0075);4dly_A(0.0088);4dlz_A(0.0083);4dlr_A(0.0084);3rsl_A(0.0063);3rs0_A(0.0075);3rso_A(0.0092);4nyi_Q(0.0077);4nyj_Q(0.0063) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0061 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 86 3rs4_A(0.0077);4nym_Q(0.0075);3rs2_A(0.0089);2cl6_X(0.0086);3rs3_A(0.0078);3rs7_A(0.0079);3v4f_A(0.0061);3l8y_A(0.0095);4dls_A(0.0081);3rrz_A(0.0105);4dlv_A(0.0097);1nvv_Q(0.0079);4dlx_A(0.0075);4dly_A(0.0088);4dlz_A(0.0083);4dlr_A(0.0084);3rsl_A(0.0063);3rs0_A(0.0075);3rso_A(0.0092);4nyi_Q(0.0077);4nyj_Q(0.0063) Hotspot R:11|C:2|S:1|D:2|V:9 0.0061 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS A59 59 86 3rs4_A(0.0077);4nym_Q(0.0075);3rs2_A(0.0089);2cl6_X(0.0086);3rs3_A(0.0078);3rs7_A(0.0079);3v4f_A(0.0061);3l8y_A(0.0095);4dls_A(0.0081);3rrz_A(0.0105);4dlv_A(0.0097);1nvv_Q(0.0079);4dlx_A(0.0075);4dly_A(0.0088);4dlz_A(0.0083);4dlr_A(0.0084);3rsl_A(0.0063);3rs0_A(0.0075);3rso_A(0.0092);4nyi_Q(0.0077);4nyj_Q(0.0063) Hotspot-linked T:1 0.0061 1 1 ucec:1 ENST00000451590 1 3d HRAS G60 60 86 3rs4_A(0.0077);4nym_Q(0.0075);3rs2_A(0.0089);2cl6_X(0.0086);3rs3_A(0.0078);3rs7_A(0.0079);3v4f_A(0.0061);3l8y_A(0.0095);4dls_A(0.0081);3rrz_A(0.0105);4dlv_A(0.0097);1nvv_Q(0.0079);4dlx_A(0.0075);4dly_A(0.0088);4dlz_A(0.0083);4dlr_A(0.0084);3rsl_A(0.0063);3rs0_A(0.0075);3rso_A(0.0092);4nyi_Q(0.0077);4nyj_Q(0.0063) Hotspot-linked S:1 0.0061 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 86 3rs4_A(0.0077);4nym_Q(0.0075);3rs2_A(0.0089);2cl6_X(0.0086);3rs3_A(0.0078);3rs7_A(0.0079);3v4f_A(0.0061);3l8y_A(0.0095);4dls_A(0.0081);3rrz_A(0.0105);4dlv_A(0.0097);1nvv_Q(0.0079);4dlx_A(0.0075);4dly_A(0.0088);4dlz_A(0.0083);4dlr_A(0.0084);3rsl_A(0.0063);3rs0_A(0.0075);3rso_A(0.0092);4nyi_Q(0.0077);4nyj_Q(0.0063) Hotspot R:19|H:2|K:10|L:9 0.0061 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d TP53 R273 273 89 3q06_A(0.0065) Hotspot P:4|C:119|S:5|H:103|L:22 0.0065 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 C275 275 89 3q06_A(0.0065) Hotspot R:1|S:4|F:10|Y:15 0.0065 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d PTEN L70 70 90 1d5r_A(0.0065) Hotspot-linked H:1 0.0065 1 1 gbm:1 ENST00000371953 3 3d PTEN R130 130 90 1d5r_A(0.0065) Hotspot P:3|Q:35|G:28|L:5 0.0065 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN T131 131 90 1d5r_A(0.0065) Hotspot-linked A:1 0.0065 1 1 gbm:1 ENST00000371953 3 3d PTEN G132 132 90 1d5r_A(0.0065) Hotspot-linked S:2|D:4|V:1 0.0065 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN M134 134 90 1d5r_A(0.0065) Hotspot-linked I:1 0.0065 1 1 ucec:1 ENST00000371953 3 3d PTEN I135 135 90 1d5r_A(0.0065) Hotspot-linked K:1 0.0065 1 1 brca:1 ENST00000371953 3 3d PTEN C136 136 90 1d5r_A(0.0065) Hotspot R:4|F:2|Y:2 0.0065 8 5 coadread:1|gbm:3|hnsc:1|skcm:1|ucec:2 ENST00000371953 3 3d PTEN G127 127 91 1d5r_A(0.0065) Hotspot-linked R:3|E:1|V:1 0.0065 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN K128 128 91 1d5r_A(0.0065) Hotspot-linked Q:2|N:3 0.0065 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN G129 129 91 1d5r_A(0.0065) Hotspot-linked R:1|E:2|V:2 0.0065 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN R130 130 91 1d5r_A(0.0065) Hotspot P:3|Q:35|G:28|L:5 0.0065 71 12 coadread:6|lusm:2|prad:1|stad:1|gbm:3|ucs:2|hnsc:1|skcm:1|ucec:49|lusc:1|cesc:3|kirc:1 ENST00000371953 3 3d PTEN T131 131 91 1d5r_A(0.0065) Hotspot-linked A:1 0.0065 1 1 gbm:1 ENST00000371953 3 3d PTEN G132 132 91 1d5r_A(0.0065) Hotspot-linked S:2|D:4|V:1 0.0065 7 4 coadread:1|gbm:4|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G165 165 91 1d5r_A(0.0065) Hotspot-linked R:3|E:4 0.0065 7 5 coadread:1|lusm:1|mbl:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN V166 166 91 1d5r_A(0.0065) Hotspot-linked I:1 0.0065 1 1 lihc:1 ENST00000371953 3 3d PTEN Q171 171 91 1d5r_A(0.0065) Hotspot-linked K:1 0.0065 1 1 lusc:1 ENST00000371953 3 3d HRAS A11 11 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot-linked D:1 0.0065 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0065 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot R:11|C:2|S:1|D:2|V:9 0.0065 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS A59 59 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot-linked T:1 0.0065 1 1 ucec:1 ENST00000451590 1 3d HRAS G60 60 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot-linked S:1 0.0065 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 92 1nvw_Q(0.0089);2lwi_A(0.0166);6q21_A(0.0065) Hotspot R:19|H:2|K:10|L:9 0.0065 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d BRAF G466 466 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot A:1|E:6|V:10 0.0065 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot-linked L:2 0.0065 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot A:9|R:3|S:1|E:2|V:6 0.0065 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF L485 485 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot-linked S:1|Y:1 0.0065 2 2 skcm:1|luad:1 ENST00000288602 6 3d BRAF D594 594 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot G:6|H:1|N:5 0.0065 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF G596 596 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot R:2|S:1|D:1|V:1 0.0065 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 93 3pri_A(0.0065);3pri_B(0.0082);3ppk_B(0.0067) Hotspot Q:2|R:1|S:1 0.0065 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d TP53 C238 238 96 3igl_A(0.0098);4ibv_A(0.0091);3kz8_B(0.0112);3kz8_A(0.0113);4mzi_A(0.0066) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0066 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d BRAF G466 466 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot A:1|E:6|V:10 0.0067 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot-linked L:2 0.0067 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot A:9|R:3|S:1|E:2|V:6 0.0067 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF D594 594 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot G:6|H:1|N:5 0.0067 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot-linked L:1 0.0067 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot R:2|S:1|D:1|V:1 0.0067 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 98 3psd_B(0.0085);3psd_A(0.0075);3psb_B(0.0072);3psb_A(0.0067);4e26_B(0.008);3ppj_B(0.0092) Hotspot Q:2|R:1|S:1 0.0067 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d THRA R284 284 99 1nav_A(0.0067) Cluster-exclusive P:1 0.0067 1 1 luad:1 ENST00000264637 4 3d THRA E285 285 99 1nav_A(0.0067) Cluster-exclusive G:1 0.0067 1 1 coadread:1 ENST00000264637 4 3d THRA K288 288 99 1nav_A(0.0067) Cluster-exclusive E:1 0.0067 1 1 ucec:1 ENST00000264637 4 3d THRA V294 294 99 1nav_A(0.0067) Cluster-exclusive I:2 0.0067 2 1 stad:2 ENST00000264637 4 3d THRA S296 296 99 1nav_A(0.0067) Cluster-exclusive F:1 0.0067 1 1 skcm:1 ENST00000264637 4 3d PTEN M35 35 101 1d5r_A(0.0069) Hotspot-linked I:1 0.0069 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 101 1d5r_A(0.0069) Hotspot-linked R:2|E:1 0.0069 3 1 gbm:3 ENST00000371953 3 3d PTEN C124 124 101 1d5r_A(0.0069) Hotspot-linked R:1|S:1|G:1 0.0069 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN K125 125 101 1d5r_A(0.0069) Hotspot-linked T:1|N:1 0.0069 2 2 coadread:1|kirc:1 ENST00000371953 3 3d PTEN A126 126 101 1d5r_A(0.0069) Hotspot-linked S:1|D:2|V:1|G:1 0.0069 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G127 127 101 1d5r_A(0.0069) Hotspot-linked R:3|E:1|V:1 0.0069 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN K128 128 101 1d5r_A(0.0069) Hotspot-linked Q:2|N:3 0.0069 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d PTEN G129 129 101 1d5r_A(0.0069) Hotspot-linked R:1|E:2|V:2 0.0069 5 4 prad:1|gbm:1|ucec:2|lusc:1 ENST00000371953 3 3d PTEN T131 131 101 1d5r_A(0.0069) Hotspot-linked A:1 0.0069 1 1 gbm:1 ENST00000371953 3 3d PTEN R159 159 101 1d5r_A(0.0069) Hotspot-linked S:1|K:1 0.0069 2 1 gbm:2 ENST00000371953 3 3d PTPN11 A72 72 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot T:3|D:2|V:2 0.0074 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot A:2|G:1|K:4 0.0074 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 F285 285 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot-linked S:1|V:1 0.0074 2 2 all:1|gbm:1 ENST00000351677 2 3d PTPN11 S502 502 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot-linked P:1|L:1 0.0074 2 2 gbm:1|laml:1 ENST00000351677 2 3d PTPN11 M504 504 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot-linked I:1 0.0074 1 1 luad:1 ENST00000351677 2 3d PTPN11 Q506 506 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot-linked P:1 0.0074 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 104 4dgp_A(0.0109);4h1o_A(0.0097);4h34_A(0.009);4gwf_B(0.0087);4gwf_A(0.0074);4dgx_A(0.01) Hotspot-linked K:2 0.0074 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 E69 69 105 4dgp_A(0.0109);4h1o_A(0.0097);4gwf_B(0.0087);4h34_A(0.009);4gwf_A(0.0074);2shp_A(0.012);4dgx_A(0.01) Hotspot-linked D:1|K:3 0.0074 4 3 coadread:2|gbm:1|pias:1 ENST00000351677 2 3d PTPN11 F71 71 105 4dgp_A(0.0109);4h1o_A(0.0097);4gwf_B(0.0087);4h34_A(0.009);4gwf_A(0.0074);2shp_A(0.012);4dgx_A(0.01) Hotspot-linked L:3 0.0074 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 105 4dgp_A(0.0109);4h1o_A(0.0097);4gwf_B(0.0087);4h34_A(0.009);4gwf_A(0.0074);2shp_A(0.012);4dgx_A(0.01) Hotspot T:3|D:2|V:2 0.0074 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 105 4dgp_A(0.0109);4h1o_A(0.0097);4gwf_B(0.0087);4h34_A(0.009);4gwf_A(0.0074);2shp_A(0.012);4dgx_A(0.01) Hotspot A:2|G:1|K:4 0.0074 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 I282 282 105 4dgp_A(0.0109);4h1o_A(0.0097);4gwf_B(0.0087);4h34_A(0.009);4gwf_A(0.0074);2shp_A(0.012);4dgx_A(0.01) Hotspot-linked M:1 0.0074 1 1 gbm:1 ENST00000351677 2 3d TP53 V173 173 107 2mej_B(0.0075) Hotspot A:2|E:1|G:2|L:15|M:12 0.0075 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 107 2mej_B(0.0075) Hotspot-linked S:1|W:2|K:1 0.0075 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 107 2mej_B(0.0075) Hotspot C:4|G:7|H:143 0.0075 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C238 238 107 2mej_B(0.0075) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0075 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 107 2mej_B(0.0075) Hotspot S:8|D:6|T:1 0.0075 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 107 2mej_B(0.0075) Hotspot-linked R:1|G:2 0.0075 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 107 2mej_B(0.0075) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0075 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 107 2mej_B(0.0075) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0075 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 107 2mej_B(0.0075) Hotspot R:1|C:8|S:5|D:9|V:2 0.0075 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 107 2mej_B(0.0075) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0075 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 107 2mej_B(0.0075) Hotspot-linked R:2|V:3|I:5 0.0075 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 R248 248 107 2mej_B(0.0075) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0075 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 107 2mej_B(0.0075) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0075 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 107 2mej_B(0.0075) Hotspot-linked S:2|F:1|N:3 0.0075 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V173 173 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot A:2|E:1|G:2|L:15|M:12 0.0075 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot-linked S:1|W:2|K:1 0.0075 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot C:4|G:7|H:143 0.0075 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0075 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot-linked R:2|T:1|L:3 0.0075 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0075 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot-linked D:1|K:2 0.0075 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 P191 191 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot-linked L:1 0.0075 1 1 skcm:1 ENST00000269305 4 3d TP53 H193 193 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot P:7|R:32|D:2|Y:13|L:11|N:1 0.0075 66 20 brca:13|paad:2|coadread:1|cll:1|esca:3|ucs:3|blca:1|hnsc:9|laml:1|ov:8|hgg:1|lihc:4|lusc:4|lgg:4|kirp:1|lusm:1|prad:1|stad:1|ucec:2|luad:5 ENST00000269305 4 3d TP53 L194 194 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot P:2|R:15|F:3|H:3 0.0075 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot V:3|I:17|K:4 0.0075 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0075 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 G244 244 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot R:1|C:8|S:5|D:9|V:2 0.0075 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 108 2ata_B(0.0126);2ata_A(0.0134);3d09_A(0.0102);4qo1_B(0.0121);2j21_A(0.0106);4agm_B(0.0097);4agm_A(0.0098);4agq_B(0.0105);4agq_A(0.0106);4ago_B(0.0103);1kzy_A(0.0127);1kzy_B(0.0133);2ahi_A(0.0122);2ahi_B(0.0137);3kmd_D(0.0126);3kmd_B(0.014);3kmd_C(0.0135);2ahi_C(0.0153);3kmd_A(0.0125);2ahi_D(0.0127);4loe_B(0.0118);3q06_A(0.0075);4loe_A(0.0114);4loe_D(0.0132);4loe_C(0.0119);1tup_C(0.0161);4ibq_B(0.0122);1tup_A(0.0138);4ibq_A(0.0141);4ibs_B(0.0138);4ibs_A(0.0145);4ibq_C(0.015);4ibs_D(0.0116);4ibu_B(0.0113);4ibs_C(0.0129);4ibu_D(0.0163);4ibw_A(0.0111);4ibu_C(0.0146);2bim_A(0.0115);2ata_D(0.0161);2bim_B(0.0117);2ata_C(0.0153);4lo9_D(0.0125);2xwr_A(0.0139);1gzh_A(0.0124);4lo9_C(0.0109);2ac0_A(0.0134);1gzh_C(0.0132);2ac0_B(0.0151);4hje_D(0.0133);4agn_B(0.0097);4hje_C(0.0134);4agn_A(0.0096);4hje_B(0.0134);3ts8_A(0.0086);4hje_A(0.0127);3d0a_D(0.0159);4agp_B(0.0114);3d0a_B(0.0131);3d0a_A(0.0125);2ady_A(0.0145);2ady_B(0.0124);4ibz_D(0.0152);4kvp_D(0.0131);4kvp_C(0.0145);4kvp_B(0.0119);4kvp_A(0.0117);2ybg_B(0.0147);2ybg_A(0.0145);4lof_A(0.0106);1tsr_C(0.0146);1tsr_A(0.0122);3q05_A(0.0087);4ijt_A(0.0115);2ocj_D(0.0113);2ocj_C(0.013);2wgx_B(0.0107);2ac0_C(0.0139);3q01_A(0.0081);2ac0_D(0.0152);4ibt_A(0.011);2ybg_C(0.0138);4ibt_C(0.0132);4ibt_B(0.0106);4ibt_D(0.0129);4ibz_A(0.0129);2bin_A(0.0101) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0075 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d PPP2R1A P179 179 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot R:12|L:1 0.0075 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked W:1 0.0075 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot Q:4|W:14|G:1 0.0075 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A A185 185 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked T:1 0.0075 1 1 coadread:1 ENST00000322088 6 3d PPP2R1A D215 215 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked H:1 0.0075 1 1 lusc:1 ENST00000322088 6 3d PPP2R1A Q217 217 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked K:1 0.0075 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A V220 220 109 2nyl_A(0.0091);3dw8_D(0.0089);2nym_A(0.0099);3dw8_A(0.0091);4i5l_D(0.0095);2nym_D(0.008);4i5n_A(0.009);2nyl_D(0.0101);4i5n_D(0.008);4i5l_A(0.0085);2npp_D(0.0095);2iae_A(0.0085);2ie4_A(0.009);2pf4_B(0.0088);2pf4_A(0.0087);2npp_A(0.0089);1b3u_B(0.0084);1b3u_A(0.0079);2ie3_A(0.0107);2pkg_A(0.0102);2pkg_B(0.0082);3fga_A(0.0094);2pf4_C(0.0089);3k7v_A(0.0075);3k7w_A(0.0081) Hotspot-linked M:1 0.0075 1 1 ucec:1 ENST00000322088 6 3d TMPRSS11E S246 246 112 2oq5_A(0.0076) Cluster-exclusive F:1 0.0076 1 1 cscc:1 ENST00000305363 4 3d TMPRSS11E F247 247 112 2oq5_A(0.0076) Cluster-exclusive Y:1 0.0076 1 1 acc:1 ENST00000305363 4 3d TMPRSS11E T250 250 112 2oq5_A(0.0076) Cluster-exclusive I:1|K:1 0.0076 2 2 lgg:1|luad:1 ENST00000305363 4 3d TMPRSS11E S254 254 112 2oq5_A(0.0076) Cluster-exclusive P:1|L:2 0.0076 3 3 acc:1|coadread:1|ucec:1 ENST00000305363 4 3d TMPRSS11E M256 256 112 2oq5_A(0.0076) Cluster-exclusive I:2 0.0076 2 1 skcm:2 ENST00000305363 4 3d TMPRSS11E S246 246 113 2oq5_A(0.0076) Cluster-exclusive F:1 0.0076 1 1 cscc:1 ENST00000305363 4 3d TMPRSS11E F247 247 113 2oq5_A(0.0076) Cluster-exclusive Y:1 0.0076 1 1 acc:1 ENST00000305363 4 3d TMPRSS11E T250 250 113 2oq5_A(0.0076) Cluster-exclusive I:1|K:1 0.0076 2 2 lgg:1|luad:1 ENST00000305363 4 3d TMPRSS11E I251 251 113 2oq5_A(0.0076) Cluster-exclusive T:1 0.0076 1 1 lihc:1 ENST00000305363 4 3d TMPRSS11E P253 253 113 2oq5_A(0.0076) Cluster-exclusive H:1 0.0076 1 1 lusc:1 ENST00000305363 4 3d TMPRSS11E S254 254 113 2oq5_A(0.0076) Cluster-exclusive P:1|L:2 0.0076 3 3 acc:1|coadread:1|ucec:1 ENST00000305363 4 3d RBBP7 E313 313 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive K:2 0.0077 2 1 coadread:2 ENST00000380087 2 3d RBBP7 S314 314 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive Y:1 0.0077 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive Y:1 0.0077 1 1 skcm:1 ENST00000380087 2 3d RBBP7 D317 317 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive N:1 0.0077 1 1 cesc:1 ENST00000380087 2 3d RBBP7 G336 336 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive D:1 0.0077 1 1 stad:1 ENST00000380087 2 3d RBBP7 R340 340 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive C:1|H:2 0.0077 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 116 2xu7_A(0.0077);3cfs_B(0.013) Cluster-exclusive T:1|H:1 0.0077 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d TP53 L330 330 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive P:1|R:1 0.0079 2 2 skcm:1|lihc:1 ENST00000269305 4 3d TP53 Q331 331 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive H:7 0.0079 7 6 paad:1|coadread:1|hnsc:2|ov:1|lusc:1|luad:1 ENST00000269305 4 3d TP53 G334 334 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive A:1|V:3|W:1 0.0079 5 2 stad:1|luad:4 ENST00000269305 4 3d TP53 R337 337 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive P:2|C:18|S:2|H:4|L:9 0.0079 35 16 acc:1|brca:2|paad:2|coadread:5|esca:1|hnsc:5|laml:1|ov:1|lihc:1|lusc:2|lgg:1|kich:1|prad:1|stad:2|cesc:1|luad:8 ENST00000269305 4 3d TP53 F338 338 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive I:1|L:1 0.0079 2 2 kich:1|stad:1 ENST00000269305 4 3d TP53 F341 341 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive S:1|L:1 0.0079 2 2 brca:1|hnsc:1 ENST00000269305 4 3d TP53 R342 342 118 1pes_D(0.0079);1pes_C(0.0084);1pes_B(0.0087);1pes_A(0.0089) Cluster-exclusive P:2|L:1 0.0079 3 2 brca:2|kirp:1 ENST00000269305 4 3d EP300 Y1397 1397 119 3biy_A(0.0079) Hotspot-linked D:1 0.0079 1 1 ucec:1 ENST00000263253 7 3d EP300 L1398 1398 119 3biy_A(0.0079) Hotspot-linked P:1 0.0079 1 1 lusc:1 ENST00000263253 7 3d EP300 D1399 1399 119 3biy_A(0.0079) Hotspot Y:2|N:16 0.0079 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 Y1446 1446 119 3biy_A(0.0079) Hotspot-linked C:1 0.0079 1 1 hnsc:1 ENST00000263253 7 3d EP300 R1627 1627 119 3biy_A(0.0079) Hotspot-linked Q:1|W:4 0.0079 5 5 coadread:1|stad:1|blca:1|skcm:1|luad:1 ENST00000263253 7 3d KRAS G12 12 129 2cl6_X(0.0088) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0088 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 129 2cl6_X(0.0088) Hotspot A:1|R:1|C:12|D:75|V:2 0.0088 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS A59 59 129 2cl6_X(0.0088) Hotspot-linked T:1|E:1|G:3 0.0088 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 129 2cl6_X(0.0088) Hotspot D:1 0.0088 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 129 2cl6_X(0.0088) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0088 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 129 2cl6_X(0.0088) Hotspot-linked G:1|K:1 0.0088 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 129 2cl6_X(0.0088) Hotspot-linked K:2 0.0088 2 2 mmyl:1|pias:1 ENST00000311936 3 3d ZNF98 E493 493 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive G:1 0.0091 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive Q:1 0.0091 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive A:1|D:1 0.0091 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive I:1 0.0091 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive T:1 0.0091 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive V:1 0.0091 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive T:1 0.0091 1 1 coadread:1 ENST00000357774 5 3d ZNF98 Q501 501 133 3brt_B(0.0091);3brv_B(0.0098);3brt_D(0.0092);3brv_D(0.0134) Cluster-exclusive K:1 0.0091 1 1 npc:1 ENST00000357774 5 3d ZNF98 E494 494 137 3brv_B(0.0098) Cluster-exclusive Q:1 0.0098 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 137 3brv_B(0.0098) Cluster-exclusive A:1|D:1 0.0098 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 137 3brv_B(0.0098) Cluster-exclusive I:1 0.0098 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 137 3brv_B(0.0098) Cluster-exclusive T:1 0.0098 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 137 3brv_B(0.0098) Cluster-exclusive V:1 0.0098 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 137 3brv_B(0.0098) Cluster-exclusive T:1 0.0098 1 1 coadread:1 ENST00000357774 5 3d ZNF98 Q501 501 137 3brv_B(0.0098) Cluster-exclusive K:1 0.0098 1 1 npc:1 ENST00000357774 5 3d ZNF98 C492 492 138 3brv_B(0.0098) Cluster-exclusive F:1 0.0098 1 1 luad:1 ENST00000357774 5 3d ZNF98 E493 493 138 3brv_B(0.0098) Cluster-exclusive G:1 0.0098 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 138 3brv_B(0.0098) Cluster-exclusive Q:1 0.0098 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 138 3brv_B(0.0098) Cluster-exclusive A:1|D:1 0.0098 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 138 3brv_B(0.0098) Cluster-exclusive I:1 0.0098 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 138 3brv_B(0.0098) Cluster-exclusive T:1 0.0098 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 138 3brv_B(0.0098) Cluster-exclusive V:1 0.0098 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 138 3brv_B(0.0098) Cluster-exclusive T:1 0.0098 1 1 coadread:1 ENST00000357774 5 3d BRAF G466 466 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot A:1|E:6|V:10 0.0102 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot-linked L:2 0.0102 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot A:9|R:3|S:1|E:2|V:6 0.0102 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF D594 594 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot G:6|H:1|N:5 0.0102 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF G596 596 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot R:2|S:1|D:1|V:1 0.0102 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 140 2fb8_B(0.0113);4h58_B(0.0123);4h58_A(0.0102);4mnf_B(0.0124);4mnf_A(0.0108) Hotspot Q:2|R:1|S:1 0.0102 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d SMAD4 P130 130 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive L:1 0.0105 1 1 paad:1 ENST00000342988 3 3d SMAD4 Y131 131 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive C:1 0.0105 1 1 paad:1 ENST00000342988 3 3d SMAD4 H132 132 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive Y:2 0.0105 2 1 brca:2 ENST00000342988 3 3d SMAD4 Y133 133 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive N:1 0.0105 1 1 blca:1 ENST00000342988 3 3d SMAD4 E134 134 143 3qsv_C(0.0105);3qsv_D(0.0114) Cluster-exclusive K:1 0.0105 1 1 coadread:1 ENST00000342988 3 3d BRAF G466 466 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot A:1|E:6|V:10 0.0106 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot-linked L:2 0.0106 2 1 skcm:2 ENST00000288602 6 3d BRAF N581 581 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot S:7|T:2|H:1|I:1 0.0106 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot G:6|H:1|N:5 0.0106 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot-linked L:1 0.0106 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot R:2|S:1|D:1|V:1 0.0106 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 146 3d4q_B(0.013);3ppk_B(0.0121);3ppj_B(0.0122);3ppk_A(0.0106) Hotspot Q:2|R:1|S:1 0.0106 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d TP53 C238 238 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot R:3|S:3|F:12|G:1|Y:15 0.011 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot S:8|D:6|T:1 0.011 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot-linked R:1|G:2 0.011 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot P:3|A:2|C:6|F:19|Y:9 0.011 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot S:5|F:13|G:1|W:1|Y:3 0.011 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot-linked R:2|V:3|I:5 0.011 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot-linked I:4 0.011 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot P:5|Q:108|W:89|G:2|L:10 0.011 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.011 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 V272 272 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot E:1|G:4|K:1|L:1|M:17 0.011 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot P:4|C:119|S:5|H:103|L:22 0.011 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot A:4|D:5|F:7|G:4|L:1 0.011 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 147 2ata_B(0.0152);2ata_A(0.0169);3igl_A(0.0153);4lo9_B(0.0164);4lo9_A(0.0164);4lo9_D(0.0177);1gzh_A(0.0153);2ac0_A(0.0169);2ac0_B(0.0184);1gzh_C(0.0154);4hje_D(0.0181);4hje_C(0.0165);4hje_B(0.0166);4hje_A(0.0181);2ady_A(0.0177);1kzy_A(0.0171);4kvp_D(0.016);2ahi_A(0.0175);2ahi_B(0.0168);3kmd_D(0.0154);3kmd_B(0.0177);3kmd_C(0.0184);2ahi_C(0.0195);2ahi_D(0.0174);3kmd_A(0.0158);1tsr_B(0.0206);3q05_A(0.011);2ac0_C(0.0189);2ac0_D(0.019);1tup_B(0.0195);2ata_D(0.0222);2ata_C(0.0182) Hotspot R:1|S:4|F:10|Y:15 0.011 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d RHOA L22 22 151 3kz1_F(0.0114) Hotspot-linked P:1|R:1 0.0114 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA T37 37 151 3kz1_F(0.0114) Hotspot-linked S:1|I:1 0.0114 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 151 3kz1_F(0.0114) Hotspot-linked C:1 0.0114 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 151 3kz1_F(0.0114) Hotspot Q:6|K:1 0.0114 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA Y42 42 151 3kz1_F(0.0114) Hotspot C:7|S:2|F:1|I:1 0.0114 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 151 3kz1_F(0.0114) Hotspot-linked V:4 0.0114 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 151 3kz1_F(0.0114) Hotspot-linked G:1|Y:1|N:1 0.0114 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d RHOA T60 60 151 3kz1_F(0.0114) Hotspot-linked K:1 0.0114 1 1 stad:1 ENST00000418115 1 3d RHOA A61 61 151 3kz1_F(0.0114) Hotspot-linked D:1|V:1 0.0114 2 2 coadread:1|stad:1 ENST00000418115 1 3d PPP3CA H151 151 154 2jog_A(0.0117) Cluster-exclusive Y:2|N:1 0.0117 3 2 coadread:1|skcm:2 ENST00000394854 3 3d PPP3CA W232 232 154 2jog_A(0.0117) Cluster-exclusive C:1 0.0117 1 1 mmyl:1 ENST00000394854 3 3d PPP3CA R279 279 154 2jog_A(0.0117) Cluster-exclusive Q:1 0.0117 1 1 stad:1 ENST00000394854 3 3d PPP3CA H281 281 154 2jog_A(0.0117) Cluster-exclusive Y:1 0.0117 1 1 stad:1 ENST00000394854 3 3d PPP3CA E282 282 154 2jog_A(0.0117) Cluster-exclusive D:1|K:1 0.0117 2 2 brca:1|cesc:1 ENST00000394854 3 3d PPP3CA I305 305 154 2jog_A(0.0117) Cluster-exclusive F:1 0.0117 1 1 prad:1 ENST00000394854 3 3d SOX6 E104 104 160 4jra_D(0.012) Cluster-exclusive D:1 0.012 1 1 luad:1 ENST00000528429 1 3d SOX6 R122 122 160 4jra_D(0.012) Cluster-exclusive C:3|H:1 0.012 4 4 coadread:1|prad:1|ucs:1|lusc:1 ENST00000528429 1 3d SOX6 R123 123 160 4jra_D(0.012) Cluster-exclusive S:1|C:1|H:1 0.012 3 3 paad:1|skcm:1|lihc:1 ENST00000528429 1 3d BRAF G466 466 167 4g9c_A(0.0128) Hotspot A:1|E:6|V:10 0.0128 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 167 4g9c_A(0.0128) Hotspot-linked L:2 0.0128 2 1 skcm:2 ENST00000288602 6 3d BRAF V471 471 167 4g9c_A(0.0128) Hotspot-linked I:1 0.0128 1 1 paad:1 ENST00000288602 6 3d BRAF L514 514 167 4g9c_A(0.0128) Hotspot-linked P:1 0.0128 1 1 luad:1 ENST00000288602 6 3d BRAF N581 581 167 4g9c_A(0.0128) Hotspot S:7|T:2|H:1|I:1 0.0128 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 167 4g9c_A(0.0128) Hotspot G:6|H:1|N:5 0.0128 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 167 4g9c_A(0.0128) Hotspot-linked L:1 0.0128 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 167 4g9c_A(0.0128) Hotspot R:2|S:1|D:1|V:1 0.0128 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 167 4g9c_A(0.0128) Hotspot Q:2|R:1|S:1 0.0128 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d HRAS A11 11 170 3lbn_A(0.0167);3rs5_A(0.0196);1p2s_A(0.0136);3rs3_A(0.0176);1p2u_A(0.0156);3lbh_A(0.018);3rs7_A(0.0179);3kud_A(0.0197);3v4f_A(0.0152);3l8z_A(0.0162);4dlt_A(0.0188);221p_A(0.0144);4dlv_A(0.0191);1nvv_Q(0.0142);4dlx_A(0.016);1xd2_A(0.0202);1nvx_Q(0.0158);3tgp_A(0.0203);4dlr_A(0.0186);1lf0_A(0.0156);4nyi_Q(0.0175);1gnr_A(0.0177);2cl7_X(0.015);4nym_Q(0.0157);3ddc_A(0.0188);1gnp_A(0.0169);3rrz_A(0.018);2lcf_A(0.0296);3rs0_A(0.0164);3rso_A(0.0199);3rs4_A(0.0168);3rs2_A(0.0183);1p2t_A(0.0158);3lbi_A(0.0183);1p2v_A(0.0155);1wq1_R(0.0173);3l8y_A(0.0198);6q21_B(0.0165);6q21_A(0.0157);4dls_A(0.0175);1k8r_A(0.0136);6q21_D(0.015);4dlu_A(0.0174);6q21_C(0.0162);1nvu_Q(0.0169);4dlw_A(0.0166);4g0n_A(0.0157);4dly_A(0.017);1nvw_Q(0.017);1iaq_B(0.016);3k8y_A(0.0173);1iaq_C(0.013);4nyj_Q(0.0161);1lfd_D(0.0174);2cl6_X(0.0175);1lfd_B(0.0184);1gnq_A(0.0151);3rry_A(0.0204);3k9l_A(0.0141);3i3s_R(0.0147);4dlz_A(0.0189);2clc_X(0.0188);3rsl_A(0.0137) Hotspot-linked D:1 0.013 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 170 3lbn_A(0.0167);3rs5_A(0.0196);1p2s_A(0.0136);3rs3_A(0.0176);1p2u_A(0.0156);3lbh_A(0.018);3rs7_A(0.0179);3kud_A(0.0197);3v4f_A(0.0152);3l8z_A(0.0162);4dlt_A(0.0188);221p_A(0.0144);4dlv_A(0.0191);1nvv_Q(0.0142);4dlx_A(0.016);1xd2_A(0.0202);1nvx_Q(0.0158);3tgp_A(0.0203);4dlr_A(0.0186);1lf0_A(0.0156);4nyi_Q(0.0175);1gnr_A(0.0177);2cl7_X(0.015);4nym_Q(0.0157);3ddc_A(0.0188);1gnp_A(0.0169);3rrz_A(0.018);2lcf_A(0.0296);3rs0_A(0.0164);3rso_A(0.0199);3rs4_A(0.0168);3rs2_A(0.0183);1p2t_A(0.0158);3lbi_A(0.0183);1p2v_A(0.0155);1wq1_R(0.0173);3l8y_A(0.0198);6q21_B(0.0165);6q21_A(0.0157);4dls_A(0.0175);1k8r_A(0.0136);6q21_D(0.015);4dlu_A(0.0174);6q21_C(0.0162);1nvu_Q(0.0169);4dlw_A(0.0166);4g0n_A(0.0157);4dly_A(0.017);1nvw_Q(0.017);1iaq_B(0.016);3k8y_A(0.0173);1iaq_C(0.013);4nyj_Q(0.0161);1lfd_D(0.0174);2cl6_X(0.0175);1lfd_B(0.0184);1gnq_A(0.0151);3rry_A(0.0204);3k9l_A(0.0141);3i3s_R(0.0147);4dlz_A(0.0189);2clc_X(0.0188);3rsl_A(0.0137) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.013 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 170 3lbn_A(0.0167);3rs5_A(0.0196);1p2s_A(0.0136);3rs3_A(0.0176);1p2u_A(0.0156);3lbh_A(0.018);3rs7_A(0.0179);3kud_A(0.0197);3v4f_A(0.0152);3l8z_A(0.0162);4dlt_A(0.0188);221p_A(0.0144);4dlv_A(0.0191);1nvv_Q(0.0142);4dlx_A(0.016);1xd2_A(0.0202);1nvx_Q(0.0158);3tgp_A(0.0203);4dlr_A(0.0186);1lf0_A(0.0156);4nyi_Q(0.0175);1gnr_A(0.0177);2cl7_X(0.015);4nym_Q(0.0157);3ddc_A(0.0188);1gnp_A(0.0169);3rrz_A(0.018);2lcf_A(0.0296);3rs0_A(0.0164);3rso_A(0.0199);3rs4_A(0.0168);3rs2_A(0.0183);1p2t_A(0.0158);3lbi_A(0.0183);1p2v_A(0.0155);1wq1_R(0.0173);3l8y_A(0.0198);6q21_B(0.0165);6q21_A(0.0157);4dls_A(0.0175);1k8r_A(0.0136);6q21_D(0.015);4dlu_A(0.0174);6q21_C(0.0162);1nvu_Q(0.0169);4dlw_A(0.0166);4g0n_A(0.0157);4dly_A(0.017);1nvw_Q(0.017);1iaq_B(0.016);3k8y_A(0.0173);1iaq_C(0.013);4nyj_Q(0.0161);1lfd_D(0.0174);2cl6_X(0.0175);1lfd_B(0.0184);1gnq_A(0.0151);3rry_A(0.0204);3k9l_A(0.0141);3i3s_R(0.0147);4dlz_A(0.0189);2clc_X(0.0188);3rsl_A(0.0137) Hotspot R:11|C:2|S:1|D:2|V:9 0.013 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS G60 60 170 3lbn_A(0.0167);3rs5_A(0.0196);1p2s_A(0.0136);3rs3_A(0.0176);1p2u_A(0.0156);3lbh_A(0.018);3rs7_A(0.0179);3kud_A(0.0197);3v4f_A(0.0152);3l8z_A(0.0162);4dlt_A(0.0188);221p_A(0.0144);4dlv_A(0.0191);1nvv_Q(0.0142);4dlx_A(0.016);1xd2_A(0.0202);1nvx_Q(0.0158);3tgp_A(0.0203);4dlr_A(0.0186);1lf0_A(0.0156);4nyi_Q(0.0175);1gnr_A(0.0177);2cl7_X(0.015);4nym_Q(0.0157);3ddc_A(0.0188);1gnp_A(0.0169);3rrz_A(0.018);2lcf_A(0.0296);3rs0_A(0.0164);3rso_A(0.0199);3rs4_A(0.0168);3rs2_A(0.0183);1p2t_A(0.0158);3lbi_A(0.0183);1p2v_A(0.0155);1wq1_R(0.0173);3l8y_A(0.0198);6q21_B(0.0165);6q21_A(0.0157);4dls_A(0.0175);1k8r_A(0.0136);6q21_D(0.015);4dlu_A(0.0174);6q21_C(0.0162);1nvu_Q(0.0169);4dlw_A(0.0166);4g0n_A(0.0157);4dly_A(0.017);1nvw_Q(0.017);1iaq_B(0.016);3k8y_A(0.0173);1iaq_C(0.013);4nyj_Q(0.0161);1lfd_D(0.0174);2cl6_X(0.0175);1lfd_B(0.0184);1gnq_A(0.0151);3rry_A(0.0204);3k9l_A(0.0141);3i3s_R(0.0147);4dlz_A(0.0189);2clc_X(0.0188);3rsl_A(0.0137) Hotspot-linked S:1 0.013 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 170 3lbn_A(0.0167);3rs5_A(0.0196);1p2s_A(0.0136);3rs3_A(0.0176);1p2u_A(0.0156);3lbh_A(0.018);3rs7_A(0.0179);3kud_A(0.0197);3v4f_A(0.0152);3l8z_A(0.0162);4dlt_A(0.0188);221p_A(0.0144);4dlv_A(0.0191);1nvv_Q(0.0142);4dlx_A(0.016);1xd2_A(0.0202);1nvx_Q(0.0158);3tgp_A(0.0203);4dlr_A(0.0186);1lf0_A(0.0156);4nyi_Q(0.0175);1gnr_A(0.0177);2cl7_X(0.015);4nym_Q(0.0157);3ddc_A(0.0188);1gnp_A(0.0169);3rrz_A(0.018);2lcf_A(0.0296);3rs0_A(0.0164);3rso_A(0.0199);3rs4_A(0.0168);3rs2_A(0.0183);1p2t_A(0.0158);3lbi_A(0.0183);1p2v_A(0.0155);1wq1_R(0.0173);3l8y_A(0.0198);6q21_B(0.0165);6q21_A(0.0157);4dls_A(0.0175);1k8r_A(0.0136);6q21_D(0.015);4dlu_A(0.0174);6q21_C(0.0162);1nvu_Q(0.0169);4dlw_A(0.0166);4g0n_A(0.0157);4dly_A(0.017);1nvw_Q(0.017);1iaq_B(0.016);3k8y_A(0.0173);1iaq_C(0.013);4nyj_Q(0.0161);1lfd_D(0.0174);2cl6_X(0.0175);1lfd_B(0.0184);1gnq_A(0.0151);3rry_A(0.0204);3k9l_A(0.0141);3i3s_R(0.0147);4dlz_A(0.0189);2clc_X(0.0188);3rsl_A(0.0137) Hotspot R:19|H:2|K:10|L:9 0.013 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d RNF111 R957 957 172 2kiz_A(0.013) Cluster-exclusive C:1 0.013 1 1 ov:1 ENST00000557998 1 3d RNF111 L958 958 172 2kiz_A(0.013) Cluster-exclusive I:1 0.013 1 1 coadread:1 ENST00000557998 1 3d RNF111 H962 962 172 2kiz_A(0.013) Cluster-exclusive Y:2 0.013 2 2 coadread:1|esca:1 ENST00000557998 1 3d RNF111 L963 963 172 2kiz_A(0.013) Cluster-exclusive R:1 0.013 1 1 coadread:1 ENST00000557998 1 3d KRAS A11 11 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot-linked T:1 0.0137 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0137 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot A:1|R:1|C:12|D:75|V:2 0.0137 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS G60 60 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot D:1 0.0137 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0137 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot-linked G:1|K:1 0.0137 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS E63 63 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot-linked K:2 0.0137 2 2 mmyl:1|pias:1 ENST00000311936 3 3d KRAS R68 68 178 1nvx_Q(0.0152);1nvu_Q(0.0137) Hotspot-linked S:1|M:1 0.0137 2 2 coadread:1|lihc:1 ENST00000311936 3 3d BRAF G466 466 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot A:1|E:6|V:10 0.014 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot-linked L:2 0.014 2 1 skcm:2 ENST00000288602 6 3d BRAF H574 574 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot-linked Q:1|N:1 0.014 2 1 luad:2 ENST00000288602 6 3d BRAF N581 581 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot S:7|T:2|H:1|I:1 0.014 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot G:6|H:1|N:5 0.014 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot-linked L:1 0.014 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot R:2|S:1|D:1|V:1 0.014 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 180 2fb8_B(0.0153);2fb8_A(0.0162);3prf_A(0.014);4h58_A(0.0153);4mnf_B(0.0164);4mnf_A(0.015) Hotspot Q:2|R:1|S:1 0.014 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d PTPN11 E69 69 187 1ayd_A(0.0157);1aya_A(0.0158);1ayb_A(0.0153);3tkz_A(0.0142) Hotspot-linked D:1|K:3 0.0142 4 3 coadread:2|gbm:1|pias:1 ENST00000351677 2 3d PTPN11 F71 71 187 1ayd_A(0.0157);1aya_A(0.0158);1ayb_A(0.0153);3tkz_A(0.0142) Hotspot-linked L:3 0.0142 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 187 1ayd_A(0.0157);1aya_A(0.0158);1ayb_A(0.0153);3tkz_A(0.0142) Hotspot T:3|D:2|V:2 0.0142 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 187 1ayd_A(0.0157);1aya_A(0.0158);1ayb_A(0.0153);3tkz_A(0.0142) Hotspot A:2|G:1|K:4 0.0142 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PIK3R1 D560 560 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot-linked G:2|H:2|N:1 0.0142 5 4 gbm:2|hnsc:1|lgg:1|luad:1 ENST00000274335 5 3d PIK3R1 N564 564 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot D:6 0.0142 6 4 coadread:2|skcm:1|ucec:1|lgg:2 ENST00000274335 5 3d PIK3R1 S565 565 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot-linked R:1|N:1 0.0142 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot E:5 0.0142 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 188 4ovu_B(0.0205);4a55_B(0.019);3hiz_B(0.0142) Hotspot-linked T:1 0.0142 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 P568 568 189 4l1b_B(0.0142) Hotspot-linked T:1 0.0142 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 D569 569 189 4l1b_B(0.0142) Hotspot-linked G:1 0.0142 1 1 gbm:1 ENST00000274335 5 3d KRAS G12 12 196 1aa9_A(0.0154) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0154 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 196 1aa9_A(0.0154) Hotspot A:1|R:1|C:12|D:75|V:2 0.0154 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS P34 34 196 1aa9_A(0.0154) Hotspot-linked L:1 0.0154 1 1 coadread:1 ENST00000311936 3 3d KRAS A59 59 196 1aa9_A(0.0154) Hotspot-linked T:1|E:1|G:3 0.0154 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 196 1aa9_A(0.0154) Hotspot D:1 0.0154 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 196 1aa9_A(0.0154) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0154 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d TP53 V173 173 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot A:2|E:1|G:2|L:15|M:12 0.0157 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot-linked S:1|W:2|K:1 0.0157 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot C:4|G:7|H:143 0.0157 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0157 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot-linked R:2|T:1|L:3 0.0157 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0157 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot-linked D:1|K:2 0.0157 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 P191 191 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot-linked L:1 0.0157 1 1 skcm:1 ENST00000269305 4 3d TP53 H193 193 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot P:7|R:32|D:2|Y:13|L:11|N:1 0.0157 66 20 brca:13|paad:2|coadread:1|cll:1|esca:3|ucs:3|blca:1|hnsc:9|laml:1|ov:8|hgg:1|lihc:4|lusc:4|lgg:4|kirp:1|lusm:1|prad:1|stad:1|ucec:2|luad:5 ENST00000269305 4 3d TP53 L194 194 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot P:2|R:15|F:3|H:3 0.0157 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot V:3|I:17|K:4 0.0157 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0157 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 G245 245 198 1uol_A(0.0195);4lo9_B(0.0242);4lo9_A(0.0236);2j21_B(0.0182);2j20_B(0.0206);1uol_B(0.0236);2j20_A(0.0225);2x0u_A(0.02);2x0v_A(0.0217);2x0u_B(0.0208);2x0v_B(0.0208);2x0w_A(0.0201);2x0w_B(0.024);4ago_A(0.0159);4agl_B(0.021);4agl_A(0.0196);3d0a_C(0.0261);2vuk_B(0.0194);4agp_A(0.0179);2vuk_A(0.0187);2pcx_A(0.0199);2j1w_A(0.02);2j1w_B(0.019);2j1x_A(0.0183);4ibz_B(0.0239);2j1x_B(0.0221);2j1z_A(0.0177);2j1z_B(0.0196);1ycs_A(0.028);3zme_A(0.0174);2bip_A(0.0179);2biq_A(0.0157);1tsr_B(0.0288);3zme_B(0.0186);2wgx_A(0.0179);1tup_B(0.0284);4ibq_D(0.0215);2ocj_B(0.0257);2ocj_A(0.0213);4iby_A(0.0211);4iby_B(0.0224) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0157 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d EP300 D1399 1399 199 3biy_A(0.0159) Hotspot Y:2|N:16 0.0159 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 Y1446 1446 199 3biy_A(0.0159) Hotspot-linked C:1 0.0159 1 1 hnsc:1 ENST00000263253 7 3d EP300 H1451 1451 199 3biy_A(0.0159) Hotspot P:1|R:1|L:1 0.0159 3 3 brca:1|blca:1|ucec:1 ENST00000263253 7 3d PIK3R1 N564 564 200 4l1b_B(0.0159) Hotspot D:6 0.0159 6 4 coadread:2|skcm:1|ucec:1|lgg:2 ENST00000274335 5 3d PIK3R1 S565 565 200 4l1b_B(0.0159) Hotspot-linked R:1|N:1 0.0159 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 200 4l1b_B(0.0159) Hotspot E:5 0.0159 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 200 4l1b_B(0.0159) Hotspot-linked T:1 0.0159 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 D569 569 200 4l1b_B(0.0159) Hotspot-linked G:1 0.0159 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 200 4l1b_B(0.0159) Hotspot-linked P:1 0.0159 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 200 4l1b_B(0.0159) Hotspot-linked R:1 0.0159 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 200 4l1b_B(0.0159) Hotspot-linked P:3 0.0159 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d ITGA4 G53 53 201 4irz_A(0.0159) Cluster-exclusive V:1 0.0159 1 1 stad:1 ENST00000397033 2 3d ITGA4 L427 427 201 4irz_A(0.0159) Cluster-exclusive V:1 0.0159 1 1 skcm:1 ENST00000397033 2 3d ITGA4 S428 428 201 4irz_A(0.0159) Cluster-exclusive T:1 0.0159 1 1 luad:1 ENST00000397033 2 3d ITGA4 G431 431 201 4irz_A(0.0159) Cluster-exclusive E:1|V:1 0.0159 2 2 blca:1|hnsc:1 ENST00000397033 2 3d ITGA4 G451 451 201 4irz_A(0.0159) Cluster-exclusive R:1 0.0159 1 1 blca:1 ENST00000397033 2 3d ITGA4 A452 452 201 4irz_A(0.0159) Cluster-exclusive V:1 0.0159 1 1 coadread:1 ENST00000397033 2 3d ITGA4 R454 454 201 4irz_A(0.0159) Cluster-exclusive W:2|L:1 0.0159 3 2 skcm:2|kirp:1 ENST00000397033 2 3d ITGA4 S455 455 201 4irz_A(0.0159) Cluster-exclusive Y:1 0.0159 1 1 cesc:1 ENST00000397033 2 3d ITGA4 S457 457 201 4irz_A(0.0159) Cluster-exclusive P:1|F:1 0.0159 2 2 ucec:1|cesc:1 ENST00000397033 2 3d ITGA4 A458 458 201 4irz_A(0.0159) Cluster-exclusive P:1 0.0159 1 1 luad:1 ENST00000397033 2 3d PTPN11 F71 71 207 4h34_A(0.0163) Hotspot-linked L:3 0.0163 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 207 4h34_A(0.0163) Hotspot T:3|D:2|V:2 0.0163 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 207 4h34_A(0.0163) Hotspot A:2|G:1|K:4 0.0163 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 Q506 506 207 4h34_A(0.0163) Hotspot-linked P:1 0.0163 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 207 4h34_A(0.0163) Hotspot-linked K:2 0.0163 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 F71 71 208 4h34_A(0.0163) Hotspot-linked L:3 0.0163 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 208 4h34_A(0.0163) Hotspot T:3|D:2|V:2 0.0163 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 208 4h34_A(0.0163) Hotspot A:2|G:1|K:4 0.0163 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 I282 282 208 4h34_A(0.0163) Hotspot-linked M:1 0.0163 1 1 gbm:1 ENST00000351677 2 3d PTPN11 Q506 506 208 4h34_A(0.0163) Hotspot-linked P:1 0.0163 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 208 4h34_A(0.0163) Hotspot-linked K:2 0.0163 2 2 gbm:1|nbl:1 ENST00000351677 2 3d UQCRFS1 F265 265 209 1qcr_E(0.0163) Cluster-exclusive L:1 0.0163 1 1 ucec:1 ENST00000304863 4 3d UQCRFS1 M270 270 209 1qcr_E(0.0163) Cluster-exclusive V:1 0.0163 1 1 hnsc:1 ENST00000304863 4 3d UQCRFS1 V271 271 209 1qcr_E(0.0163) Cluster-exclusive A:1 0.0163 1 1 stad:1 ENST00000304863 4 3d UQCRFS1 I272 272 209 1qcr_E(0.0163) Cluster-exclusive T:1 0.0163 1 1 coadread:1 ENST00000304863 4 3d SPOP F102 102 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot C:2|V:2|L:1 0.0166 5 1 prad:5 ENST00000347630 2 3d SPOP K103 103 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked N:1 0.0166 1 1 ucec:1 ENST00000347630 2 3d SPOP F104 104 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked S:1|I:1 0.0166 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked V:4 0.0166 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked R:1|N:1 0.0166 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP F133 133 211 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot S:3|C:4|V:4|I:2|L:9 0.0166 22 1 prad:22 ENST00000347630 2 3d SPOP F102 102 212 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot C:2|V:2|L:1 0.0166 5 1 prad:5 ENST00000347630 2 3d SPOP M117 117 212 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked V:4 0.0166 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 212 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot-linked R:1|N:1 0.0166 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP F133 133 212 3hqi_B(0.0181);3hqi_A(0.0188);3hu6_A(0.0166);3hu6_B(0.0166) Hotspot S:3|C:4|V:4|I:2|L:9 0.0166 22 1 prad:22 ENST00000347630 2 3d TP53 V173 173 215 2mej_B(0.017) Hotspot A:2|E:1|G:2|L:15|M:12 0.017 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 215 2mej_B(0.017) Hotspot-linked S:1|W:2|K:1 0.017 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 215 2mej_B(0.017) Hotspot C:4|G:7|H:143 0.017 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 215 2mej_B(0.017) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.017 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 215 2mej_B(0.017) Hotspot-linked R:2|T:1|L:3 0.017 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 215 2mej_B(0.017) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.017 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 215 2mej_B(0.017) Hotspot-linked D:1|K:2 0.017 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 P191 191 215 2mej_B(0.017) Hotspot-linked L:1 0.017 1 1 skcm:1 ENST00000269305 4 3d TP53 H193 193 215 2mej_B(0.017) Hotspot P:7|R:32|D:2|Y:13|L:11|N:1 0.017 66 20 brca:13|paad:2|coadread:1|cll:1|esca:3|ucs:3|blca:1|hnsc:9|laml:1|ov:8|hgg:1|lihc:4|lusc:4|lgg:4|kirp:1|lusm:1|prad:1|stad:1|ucec:2|luad:5 ENST00000269305 4 3d TP53 L194 194 215 2mej_B(0.017) Hotspot P:2|R:15|F:3|H:3 0.017 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 215 2mej_B(0.017) Hotspot V:3|I:17|K:4 0.017 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 215 2mej_B(0.017) Hotspot R:3|S:3|F:12|G:1|Y:15 0.017 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 M243 243 215 2mej_B(0.017) Hotspot-linked I:1 0.017 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 215 2mej_B(0.017) Hotspot R:1|C:8|S:5|D:9|V:2 0.017 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 215 2mej_B(0.017) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.017 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 215 2mej_B(0.017) Hotspot-linked R:2|V:3|I:5 0.017 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d RHOA L22 22 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked P:1|R:1 0.0171 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA T37 37 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked S:1|I:1 0.0171 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked C:1 0.0171 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot Q:6|K:1 0.0171 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked K:1 0.0171 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot C:7|S:2|F:1|I:1 0.0171 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked V:4 0.0171 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 217 3lwn_A(0.0228);3lwn_B(0.0219);2gco_B(0.0191);3lw8_A(0.0178);1lb1_F(0.024);3lw8_B(0.0208);2gcn_A(0.0171);3lw8_C(0.0203);3lw8_D(0.0204);2gco_A(0.0196);1lb1_H(0.0225);1lb1_B(0.0233);1lb1_D(0.021);1dpf_A(0.021);4xh9_E(0.0225);4xh9_B(0.0201);1ftn_A(0.0212);2rgn_C(0.0212);4d0n_A(0.0201);3lxr_A(0.0214);2rgn_F(0.0181);1xcg_B(0.0204);3t06_B(0.0179);3t06_F(0.0208);3tvd_A(0.0185);1xcg_F(0.0211);1x86_D(0.0232);1x86_B(0.0201);1x86_H(0.0199);1cc0_C(0.0181);1x86_F(0.021);1cc0_A(0.0195) Hotspot-linked G:1|Y:1|N:1 0.0171 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d TP53 C238 238 219 2mej_B(0.0176) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0176 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 219 2mej_B(0.0176) Hotspot S:8|D:6|T:1 0.0176 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 219 2mej_B(0.0176) Hotspot-linked R:1|G:2 0.0176 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 219 2mej_B(0.0176) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0176 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 219 2mej_B(0.0176) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0176 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 219 2mej_B(0.0176) Hotspot-linked R:2|V:3|I:5 0.0176 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 219 2mej_B(0.0176) Hotspot-linked I:4 0.0176 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 219 2mej_B(0.0176) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0176 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 219 2mej_B(0.0176) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0176 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 P250 250 219 2mej_B(0.0176) Hotspot-linked L:12 0.0176 12 9 paad:1|coadread:1|kich:1|stad:1|ov:2|gbc:1|lusc:1|lgg:2|luad:2 ENST00000269305 4 3d TP53 I251 251 219 2mej_B(0.0176) Hotspot-linked S:2|F:1|N:3 0.0176 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V272 272 219 2mej_B(0.0176) Hotspot E:1|G:4|K:1|L:1|M:17 0.0176 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 219 2mej_B(0.0176) Hotspot P:4|C:119|S:5|H:103|L:22 0.0176 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 219 2mej_B(0.0176) Hotspot A:4|D:5|F:7|G:4|L:1 0.0176 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 219 2mej_B(0.0176) Hotspot R:1|S:4|F:10|Y:15 0.0176 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d HRAS A11 11 220 1xj0_A(0.0177) Hotspot-linked D:1 0.0177 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 220 1xj0_A(0.0177) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0177 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 220 1xj0_A(0.0177) Hotspot R:11|C:2|S:1|D:2|V:9 0.0177 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS Q61 61 220 1xj0_A(0.0177) Hotspot R:19|H:2|K:10|L:9 0.0177 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d HRAS V81 81 220 1xj0_A(0.0177) Hotspot-linked M:1 0.0177 1 1 gbc:1 ENST00000451590 1 3d BRAF N581 581 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot S:7|T:2|H:1|I:1 0.0177 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot G:6|H:1|N:5 0.0177 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot-linked L:1 0.0177 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot R:2|S:1|D:1|V:1 0.0177 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot Q:2|R:1|S:1 0.0177 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF K601 601 221 4g9r_B(0.0177);1uwj_A(0.019);4g9r_A(0.0205) Hotspot T:1|E:12|N:2 0.0177 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d CD300C P34 34 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive T:1 0.0177 1 1 lihc:1 ENST00000330793 1 3d CD300C V35 35 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive L:2 0.0177 2 2 lihc:1|luad:1 ENST00000330793 1 3d CD300C L97 97 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive Q:1 0.0177 1 1 luad:1 ENST00000330793 1 3d CD300C E98 98 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive D:1 0.0177 1 1 ucec:1 ENST00000330793 1 3d CD300C L100 100 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive P:1 0.0177 1 1 brca:1 ENST00000330793 1 3d CD300C E102 102 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive D:2 0.0177 2 2 ucec:1|luad:1 ENST00000330793 1 3d CD300C D104 104 222 2q87_B(0.0177);2q87_C(0.0183) Cluster-exclusive E:2 0.0177 2 1 luad:2 ENST00000330793 1 3d KRAS A11 11 225 3lbn_A(0.021);3rs5_A(0.0235);1p2s_A(0.0179);3rs3_A(0.0238);1p2u_A(0.0189);3lbh_A(0.0209);3rs7_A(0.0207);3v4f_A(0.0229);3l8z_A(0.0198);4dlt_A(0.0237);221p_A(0.0191);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);1xd2_A(0.0252);3tgp_A(0.0266);4dlr_A(0.0203);1lf0_A(0.0211);1gnr_A(0.0187);2cl7_X(0.0218);3ddc_A(0.0227);1gnp_A(0.0227);3rrz_A(0.0237);2lcf_A(0.0322);3rs0_A(0.0206);3rso_A(0.0207);3rs4_A(0.0229);3rs2_A(0.0213);1p2t_A(0.0209);1p2v_A(0.0213);3lbi_A(0.0218);1wq1_R(0.021);3l8y_A(0.023);4dls_A(0.02);6q21_A(0.023);1k8r_A(0.02);4dlu_A(0.0224);4dlw_A(0.0222);4g0n_A(0.0199);4dly_A(0.0229);1nvw_Q(0.0192);3k8y_A(0.0226);1lfd_B(0.0196);2cl6_X(0.0211);1gnq_A(0.0201);3rry_A(0.0212);3i3s_R(0.0186);4dlz_A(0.023);2clc_X(0.0207) Hotspot-linked T:1 0.0179 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 225 3lbn_A(0.021);3rs5_A(0.0235);1p2s_A(0.0179);3rs3_A(0.0238);1p2u_A(0.0189);3lbh_A(0.0209);3rs7_A(0.0207);3v4f_A(0.0229);3l8z_A(0.0198);4dlt_A(0.0237);221p_A(0.0191);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);1xd2_A(0.0252);3tgp_A(0.0266);4dlr_A(0.0203);1lf0_A(0.0211);1gnr_A(0.0187);2cl7_X(0.0218);3ddc_A(0.0227);1gnp_A(0.0227);3rrz_A(0.0237);2lcf_A(0.0322);3rs0_A(0.0206);3rso_A(0.0207);3rs4_A(0.0229);3rs2_A(0.0213);1p2t_A(0.0209);1p2v_A(0.0213);3lbi_A(0.0218);1wq1_R(0.021);3l8y_A(0.023);4dls_A(0.02);6q21_A(0.023);1k8r_A(0.02);4dlu_A(0.0224);4dlw_A(0.0222);4g0n_A(0.0199);4dly_A(0.0229);1nvw_Q(0.0192);3k8y_A(0.0226);1lfd_B(0.0196);2cl6_X(0.0211);1gnq_A(0.0201);3rry_A(0.0212);3i3s_R(0.0186);4dlz_A(0.023);2clc_X(0.0207) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0179 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 225 3lbn_A(0.021);3rs5_A(0.0235);1p2s_A(0.0179);3rs3_A(0.0238);1p2u_A(0.0189);3lbh_A(0.0209);3rs7_A(0.0207);3v4f_A(0.0229);3l8z_A(0.0198);4dlt_A(0.0237);221p_A(0.0191);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);1xd2_A(0.0252);3tgp_A(0.0266);4dlr_A(0.0203);1lf0_A(0.0211);1gnr_A(0.0187);2cl7_X(0.0218);3ddc_A(0.0227);1gnp_A(0.0227);3rrz_A(0.0237);2lcf_A(0.0322);3rs0_A(0.0206);3rso_A(0.0207);3rs4_A(0.0229);3rs2_A(0.0213);1p2t_A(0.0209);1p2v_A(0.0213);3lbi_A(0.0218);1wq1_R(0.021);3l8y_A(0.023);4dls_A(0.02);6q21_A(0.023);1k8r_A(0.02);4dlu_A(0.0224);4dlw_A(0.0222);4g0n_A(0.0199);4dly_A(0.0229);1nvw_Q(0.0192);3k8y_A(0.0226);1lfd_B(0.0196);2cl6_X(0.0211);1gnq_A(0.0201);3rry_A(0.0212);3i3s_R(0.0186);4dlz_A(0.023);2clc_X(0.0207) Hotspot A:1|R:1|C:12|D:75|V:2 0.0179 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS G60 60 225 3lbn_A(0.021);3rs5_A(0.0235);1p2s_A(0.0179);3rs3_A(0.0238);1p2u_A(0.0189);3lbh_A(0.0209);3rs7_A(0.0207);3v4f_A(0.0229);3l8z_A(0.0198);4dlt_A(0.0237);221p_A(0.0191);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);1xd2_A(0.0252);3tgp_A(0.0266);4dlr_A(0.0203);1lf0_A(0.0211);1gnr_A(0.0187);2cl7_X(0.0218);3ddc_A(0.0227);1gnp_A(0.0227);3rrz_A(0.0237);2lcf_A(0.0322);3rs0_A(0.0206);3rso_A(0.0207);3rs4_A(0.0229);3rs2_A(0.0213);1p2t_A(0.0209);1p2v_A(0.0213);3lbi_A(0.0218);1wq1_R(0.021);3l8y_A(0.023);4dls_A(0.02);6q21_A(0.023);1k8r_A(0.02);4dlu_A(0.0224);4dlw_A(0.0222);4g0n_A(0.0199);4dly_A(0.0229);1nvw_Q(0.0192);3k8y_A(0.0226);1lfd_B(0.0196);2cl6_X(0.0211);1gnq_A(0.0201);3rry_A(0.0212);3i3s_R(0.0186);4dlz_A(0.023);2clc_X(0.0207) Hotspot D:1 0.0179 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 225 3lbn_A(0.021);3rs5_A(0.0235);1p2s_A(0.0179);3rs3_A(0.0238);1p2u_A(0.0189);3lbh_A(0.0209);3rs7_A(0.0207);3v4f_A(0.0229);3l8z_A(0.0198);4dlt_A(0.0237);221p_A(0.0191);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);1xd2_A(0.0252);3tgp_A(0.0266);4dlr_A(0.0203);1lf0_A(0.0211);1gnr_A(0.0187);2cl7_X(0.0218);3ddc_A(0.0227);1gnp_A(0.0227);3rrz_A(0.0237);2lcf_A(0.0322);3rs0_A(0.0206);3rso_A(0.0207);3rs4_A(0.0229);3rs2_A(0.0213);1p2t_A(0.0209);1p2v_A(0.0213);3lbi_A(0.0218);1wq1_R(0.021);3l8y_A(0.023);4dls_A(0.02);6q21_A(0.023);1k8r_A(0.02);4dlu_A(0.0224);4dlw_A(0.0222);4g0n_A(0.0199);4dly_A(0.0229);1nvw_Q(0.0192);3k8y_A(0.0226);1lfd_B(0.0196);2cl6_X(0.0211);1gnq_A(0.0201);3rry_A(0.0212);3i3s_R(0.0186);4dlz_A(0.023);2clc_X(0.0207) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0179 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d NRAS G12 12 226 3lbn_A(0.0214);3rs5_A(0.0185);1p2s_A(0.0188);3rs3_A(0.0226);3lbh_A(0.0219);3rs7_A(0.0209);3v4f_A(0.0195);3kud_A(0.0211);3l8z_A(0.0217);4dlt_A(0.0222);221p_A(0.0187);4dlv_A(0.0221);1nvv_Q(0.0209);4dlx_A(0.0233);1xd2_A(0.0248);1nvx_Q(0.0193);3tgp_A(0.0221);4dlr_A(0.0229);1lf0_A(0.0186);1gnr_A(0.0218);2cl7_X(0.0219);3ddc_A(0.0216);1gnp_A(0.0224);3rrz_A(0.0208);2lcf_A(0.0302);3rs0_A(0.0218);3rso_A(0.0224);3rs4_A(0.018);3rs2_A(0.0219);3lbi_A(0.0236);1p2v_A(0.0216);1wq1_R(0.0212);3l8y_A(0.0213);4dls_A(0.0213);6q21_A(0.0199);1k8r_A(0.0207);4dlu_A(0.022);1nvu_Q(0.0208);4g0n_A(0.0213);4dlw_A(0.0195);4dly_A(0.0202);1nvw_Q(0.0214);3k8y_A(0.0222);2cl6_X(0.0193);1lfd_B(0.0205);1gnq_A(0.0207);3rry_A(0.0242);3i3s_R(0.0192);4dlz_A(0.0217);2lwi_A(0.0322);2clc_X(0.0203) Hotspot A:3|R:2|C:7|S:3|D:18|V:3 0.018 36 7 mmyl:3|coadread:15|stad:1|laml:6|skcm:7|ucec:2|mds:2 ENST00000369535 4 3d NRAS G13 13 226 3lbn_A(0.0214);3rs5_A(0.0185);1p2s_A(0.0188);3rs3_A(0.0226);3lbh_A(0.0219);3rs7_A(0.0209);3v4f_A(0.0195);3kud_A(0.0211);3l8z_A(0.0217);4dlt_A(0.0222);221p_A(0.0187);4dlv_A(0.0221);1nvv_Q(0.0209);4dlx_A(0.0233);1xd2_A(0.0248);1nvx_Q(0.0193);3tgp_A(0.0221);4dlr_A(0.0229);1lf0_A(0.0186);1gnr_A(0.0218);2cl7_X(0.0219);3ddc_A(0.0216);1gnp_A(0.0224);3rrz_A(0.0208);2lcf_A(0.0302);3rs0_A(0.0218);3rso_A(0.0224);3rs4_A(0.018);3rs2_A(0.0219);3lbi_A(0.0236);1p2v_A(0.0216);1wq1_R(0.0212);3l8y_A(0.0213);4dls_A(0.0213);6q21_A(0.0199);1k8r_A(0.0207);4dlu_A(0.022);1nvu_Q(0.0208);4g0n_A(0.0213);4dlw_A(0.0195);4dly_A(0.0202);1nvw_Q(0.0214);3k8y_A(0.0222);2cl6_X(0.0193);1lfd_B(0.0205);1gnq_A(0.0207);3rry_A(0.0242);3i3s_R(0.0192);4dlz_A(0.0217);2lwi_A(0.0322);2clc_X(0.0203) Hotspot R:10|D:11|V:1 0.018 22 9 mmyl:5|coadread:3|stad:1|blca:1|dlbc:1|laml:5|mbl:1|skcm:3|mds:2 ENST00000369535 4 3d NRAS G60 60 226 3lbn_A(0.0214);3rs5_A(0.0185);1p2s_A(0.0188);3rs3_A(0.0226);3lbh_A(0.0219);3rs7_A(0.0209);3v4f_A(0.0195);3kud_A(0.0211);3l8z_A(0.0217);4dlt_A(0.0222);221p_A(0.0187);4dlv_A(0.0221);1nvv_Q(0.0209);4dlx_A(0.0233);1xd2_A(0.0248);1nvx_Q(0.0193);3tgp_A(0.0221);4dlr_A(0.0229);1lf0_A(0.0186);1gnr_A(0.0218);2cl7_X(0.0219);3ddc_A(0.0216);1gnp_A(0.0224);3rrz_A(0.0208);2lcf_A(0.0302);3rs0_A(0.0218);3rso_A(0.0224);3rs4_A(0.018);3rs2_A(0.0219);3lbi_A(0.0236);1p2v_A(0.0216);1wq1_R(0.0212);3l8y_A(0.0213);4dls_A(0.0213);6q21_A(0.0199);1k8r_A(0.0207);4dlu_A(0.022);1nvu_Q(0.0208);4g0n_A(0.0213);4dlw_A(0.0195);4dly_A(0.0202);1nvw_Q(0.0214);3k8y_A(0.0222);2cl6_X(0.0193);1lfd_B(0.0205);1gnq_A(0.0207);3rry_A(0.0242);3i3s_R(0.0192);4dlz_A(0.0217);2lwi_A(0.0322);2clc_X(0.0203) Hotspot-linked 0.018 1 ENST00000369535 4 3d NRAS Q61 61 226 3lbn_A(0.0214);3rs5_A(0.0185);1p2s_A(0.0188);3rs3_A(0.0226);3lbh_A(0.0219);3rs7_A(0.0209);3v4f_A(0.0195);3kud_A(0.0211);3l8z_A(0.0217);4dlt_A(0.0222);221p_A(0.0187);4dlv_A(0.0221);1nvv_Q(0.0209);4dlx_A(0.0233);1xd2_A(0.0248);1nvx_Q(0.0193);3tgp_A(0.0221);4dlr_A(0.0229);1lf0_A(0.0186);1gnr_A(0.0218);2cl7_X(0.0219);3ddc_A(0.0216);1gnp_A(0.0224);3rrz_A(0.0208);2lcf_A(0.0302);3rs0_A(0.0218);3rso_A(0.0224);3rs4_A(0.018);3rs2_A(0.0219);3lbi_A(0.0236);1p2v_A(0.0216);1wq1_R(0.0212);3l8y_A(0.0213);4dls_A(0.0213);6q21_A(0.0199);1k8r_A(0.0207);4dlu_A(0.022);1nvu_Q(0.0208);4g0n_A(0.0213);4dlw_A(0.0195);4dly_A(0.0202);1nvw_Q(0.0214);3k8y_A(0.0222);2cl6_X(0.0193);1lfd_B(0.0205);1gnq_A(0.0207);3rry_A(0.0242);3i3s_R(0.0192);4dlz_A(0.0217);2lwi_A(0.0322);2clc_X(0.0203) Hotspot P:1|R:113|H:16|K:73|L:27 0.018 230 17 acc:1|mmyl:27|npc:1|coadread:16|cll:4|thca:34|laml:6|blca:3|ov:2|lihc:1|lgg:1|kich:1|stad:2|gbm:1|skcm:122|ucec:4|luad:4 ENST00000369535 4 3d RBBP7 V297 297 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive L:1 0.0187 1 1 ov:1 ENST00000380087 2 3d RBBP7 E313 313 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive K:2 0.0187 2 1 coadread:2 ENST00000380087 2 3d RBBP7 S314 314 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive Y:1 0.0187 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive Y:1 0.0187 1 1 skcm:1 ENST00000380087 2 3d RBBP7 D317 317 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive N:1 0.0187 1 1 cesc:1 ENST00000380087 2 3d RBBP7 G336 336 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive D:1 0.0187 1 1 stad:1 ENST00000380087 2 3d RBBP7 R340 340 230 2yba_B(0.0501);3c99_A(0.0187);2xyi_A(0.0205) Cluster-exclusive C:1|H:2 0.0187 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d KRAS A11 11 231 3tgp_A(0.0188) Hotspot-linked T:1 0.0188 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 231 3tgp_A(0.0188) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0188 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 231 3tgp_A(0.0188) Hotspot A:1|R:1|C:12|D:75|V:2 0.0188 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS A59 59 231 3tgp_A(0.0188) Hotspot-linked T:1|E:1|G:3 0.0188 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 231 3tgp_A(0.0188) Hotspot D:1 0.0188 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 231 3tgp_A(0.0188) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0188 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 231 3tgp_A(0.0188) Hotspot-linked G:1|K:1 0.0188 2 2 skcm:1|lihc:1 ENST00000311936 3 3d HRAS A11 11 232 3rs4_A(0.0239);3rs2_A(0.027);3rs3_A(0.0241);1xj0_A(0.0253);3rs7_A(0.0237);3l8y_A(0.0279);3v4f_A(0.0218);6q21_A(0.0214);4dls_A(0.0249);4dlv_A(0.0262);1nvu_Q(0.0234);1nvv_Q(0.019);4dlx_A(0.0234);4dly_A(0.0231);1nvx_Q(0.0232);1nvw_Q(0.0229);4dlr_A(0.0247);4nyi_Q(0.0241);4nyj_Q(0.0224);4nym_Q(0.0228);2cl6_X(0.0232);3rrz_A(0.0245);4dlz_A(0.0262);4q21_A(0.0223);3rsl_A(0.0193);3rs0_A(0.0231);3rso_A(0.0266) Hotspot-linked D:1 0.019 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 232 3rs4_A(0.0239);3rs2_A(0.027);3rs3_A(0.0241);1xj0_A(0.0253);3rs7_A(0.0237);3l8y_A(0.0279);3v4f_A(0.0218);6q21_A(0.0214);4dls_A(0.0249);4dlv_A(0.0262);1nvu_Q(0.0234);1nvv_Q(0.019);4dlx_A(0.0234);4dly_A(0.0231);1nvx_Q(0.0232);1nvw_Q(0.0229);4dlr_A(0.0247);4nyi_Q(0.0241);4nyj_Q(0.0224);4nym_Q(0.0228);2cl6_X(0.0232);3rrz_A(0.0245);4dlz_A(0.0262);4q21_A(0.0223);3rsl_A(0.0193);3rs0_A(0.0231);3rso_A(0.0266) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.019 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS G13 13 232 3rs4_A(0.0239);3rs2_A(0.027);3rs3_A(0.0241);1xj0_A(0.0253);3rs7_A(0.0237);3l8y_A(0.0279);3v4f_A(0.0218);6q21_A(0.0214);4dls_A(0.0249);4dlv_A(0.0262);1nvu_Q(0.0234);1nvv_Q(0.019);4dlx_A(0.0234);4dly_A(0.0231);1nvx_Q(0.0232);1nvw_Q(0.0229);4dlr_A(0.0247);4nyi_Q(0.0241);4nyj_Q(0.0224);4nym_Q(0.0228);2cl6_X(0.0232);3rrz_A(0.0245);4dlz_A(0.0262);4q21_A(0.0223);3rsl_A(0.0193);3rs0_A(0.0231);3rso_A(0.0266) Hotspot R:11|C:2|S:1|D:2|V:9 0.019 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS Q61 61 232 3rs4_A(0.0239);3rs2_A(0.027);3rs3_A(0.0241);1xj0_A(0.0253);3rs7_A(0.0237);3l8y_A(0.0279);3v4f_A(0.0218);6q21_A(0.0214);4dls_A(0.0249);4dlv_A(0.0262);1nvu_Q(0.0234);1nvv_Q(0.019);4dlx_A(0.0234);4dly_A(0.0231);1nvx_Q(0.0232);1nvw_Q(0.0229);4dlr_A(0.0247);4nyi_Q(0.0241);4nyj_Q(0.0224);4nym_Q(0.0228);2cl6_X(0.0232);3rrz_A(0.0245);4dlz_A(0.0262);4q21_A(0.0223);3rsl_A(0.0193);3rs0_A(0.0231);3rso_A(0.0266) Hotspot R:19|H:2|K:10|L:9 0.019 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d KRAS A11 11 236 1nvw_Q(0.0192) Hotspot-linked T:1 0.0192 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 236 1nvw_Q(0.0192) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0192 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 236 1nvw_Q(0.0192) Hotspot A:1|R:1|C:12|D:75|V:2 0.0192 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS G60 60 236 1nvw_Q(0.0192) Hotspot D:1 0.0192 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 236 1nvw_Q(0.0192) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0192 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 236 1nvw_Q(0.0192) Hotspot-linked G:1|K:1 0.0192 2 2 skcm:1|lihc:1 ENST00000311936 3 3d KRAS D92 92 236 1nvw_Q(0.0192) Hotspot-linked Y:1 0.0192 1 1 brca:1 ENST00000311936 3 3d KRAS A11 11 237 3rs4_A(0.0229);3rs2_A(0.0213);2cl6_X(0.0211);3rs3_A(0.0238);1xj0_A(0.0234);3rs7_A(0.0207);3v4f_A(0.0229);3l8y_A(0.023);6q21_A(0.023);4dls_A(0.02);3rrz_A(0.0237);1nvu_Q(0.0231);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);4dly_A(0.0229);4dlz_A(0.023);1nvw_Q(0.0192);1nvx_Q(0.0232);4q21_A(0.0245);4dlr_A(0.0203);3rs0_A(0.0206);3rso_A(0.0207) Hotspot-linked T:1 0.0192 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 237 3rs4_A(0.0229);3rs2_A(0.0213);2cl6_X(0.0211);3rs3_A(0.0238);1xj0_A(0.0234);3rs7_A(0.0207);3v4f_A(0.0229);3l8y_A(0.023);6q21_A(0.023);4dls_A(0.02);3rrz_A(0.0237);1nvu_Q(0.0231);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);4dly_A(0.0229);4dlz_A(0.023);1nvw_Q(0.0192);1nvx_Q(0.0232);4q21_A(0.0245);4dlr_A(0.0203);3rs0_A(0.0206);3rso_A(0.0207) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0192 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 237 3rs4_A(0.0229);3rs2_A(0.0213);2cl6_X(0.0211);3rs3_A(0.0238);1xj0_A(0.0234);3rs7_A(0.0207);3v4f_A(0.0229);3l8y_A(0.023);6q21_A(0.023);4dls_A(0.02);3rrz_A(0.0237);1nvu_Q(0.0231);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);4dly_A(0.0229);4dlz_A(0.023);1nvw_Q(0.0192);1nvx_Q(0.0232);4q21_A(0.0245);4dlr_A(0.0203);3rs0_A(0.0206);3rso_A(0.0207) Hotspot A:1|R:1|C:12|D:75|V:2 0.0192 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS Q61 61 237 3rs4_A(0.0229);3rs2_A(0.0213);2cl6_X(0.0211);3rs3_A(0.0238);1xj0_A(0.0234);3rs7_A(0.0207);3v4f_A(0.0229);3l8y_A(0.023);6q21_A(0.023);4dls_A(0.02);3rrz_A(0.0237);1nvu_Q(0.0231);4dlv_A(0.0196);1nvv_Q(0.0195);4dlx_A(0.0214);4dly_A(0.0229);4dlz_A(0.023);1nvw_Q(0.0192);1nvx_Q(0.0232);4q21_A(0.0245);4dlr_A(0.0203);3rs0_A(0.0206);3rso_A(0.0207) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0192 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d NRAS G12 12 238 2cl6_X(0.0193) Hotspot A:3|R:2|C:7|S:3|D:18|V:3 0.0193 36 7 mmyl:3|coadread:15|stad:1|laml:6|skcm:7|ucec:2|mds:2 ENST00000369535 4 3d NRAS G13 13 238 2cl6_X(0.0193) Hotspot R:10|D:11|V:1 0.0193 22 9 mmyl:5|coadread:3|stad:1|blca:1|dlbc:1|laml:5|mbl:1|skcm:3|mds:2 ENST00000369535 4 3d NRAS Q61 61 238 2cl6_X(0.0193) Hotspot P:1|R:113|H:16|K:73|L:27 0.0193 230 17 acc:1|mmyl:27|npc:1|coadread:16|cll:4|thca:34|laml:6|blca:3|ov:2|lihc:1|lgg:1|kich:1|stad:2|gbm:1|skcm:122|ucec:4|luad:4 ENST00000369535 4 3d BRAF D594 594 239 3tv4_B(0.0194) Hotspot G:6|H:1|N:5 0.0194 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 239 3tv4_B(0.0194) Hotspot-linked L:1 0.0194 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 239 3tv4_B(0.0194) Hotspot R:2|S:1|D:1|V:1 0.0194 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 239 3tv4_B(0.0194) Hotspot Q:2|R:1|S:1 0.0194 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 239 3tv4_B(0.0194) Hotspot R:4|E:509|K:32 0.0194 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 239 3tv4_B(0.0194) Hotspot T:1|E:12|N:2 0.0194 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d IQUB V135 135 241 2daf_A(0.0194) Cluster-exclusive F:1|L:1 0.0194 2 2 brca:1|lusc:1 ENST00000324698 6 3d IQUB V136 136 241 2daf_A(0.0194) Cluster-exclusive L:2 0.0194 2 2 skcm:1|luad:1 ENST00000324698 6 3d IQUB E143 143 241 2daf_A(0.0194) Cluster-exclusive K:2 0.0194 2 2 skcm:1|cscc:1 ENST00000324698 6 3d IQUB V145 145 241 2daf_A(0.0194) Cluster-exclusive L:1 0.0194 1 1 lusm:1 ENST00000324698 6 3d TP53 C238 238 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0195 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot S:8|D:6|T:1 0.0195 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot-linked R:1|G:2 0.0195 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0195 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0195 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot-linked R:2|V:3|I:5 0.0195 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot-linked I:4 0.0195 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0195 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0195 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 V272 272 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot E:1|G:4|K:1|L:1|M:17 0.0195 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot P:4|C:119|S:5|H:103|L:22 0.0195 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 242 2xwr_B(0.025);4kvp_C(0.0301);4kvp_B(0.0294);4kvp_A(0.0281);4qo1_B(0.0276);2ybg_B(0.0314);2xwr_A(0.0293);1kzy_B(0.0325);2ybg_A(0.0346);4lo9_C(0.0277);1ycs_A(0.0339);1tsr_A(0.0286);2ocj_D(0.0287);2ocj_C(0.0303);1tup_A(0.0318);3ts8_A(0.0195);3q01_A(0.0205);2ybg_C(0.0298);2ocj_B(0.0322);3kz8_B(0.0289);3kz8_A(0.0291);2ocj_A(0.0285);4mzi_A(0.0195);2ady_B(0.0298) Hotspot A:4|D:5|F:7|G:4|L:1 0.0195 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d ITGA1 Q303 303 244 2m32_A(0.0196) Cluster-exclusive E:1 0.0196 1 1 prad:1 ENST00000282588 6 3d ITGA1 R304 304 244 2m32_A(0.0196) Cluster-exclusive Q:1 0.0196 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 244 2m32_A(0.0196) Cluster-exclusive F:1 0.0196 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 244 2m32_A(0.0196) Cluster-exclusive S:1 0.0196 1 1 mcl:1 ENST00000282588 6 3d ITGA1 E333 333 244 2m32_A(0.0196) Cluster-exclusive G:1|K:1 0.0196 2 2 skcm:1|lihc:1 ENST00000282588 6 3d ITGA1 E336 336 244 2m32_A(0.0196) Cluster-exclusive K:1 0.0196 1 1 cscc:1 ENST00000282588 6 3d ITGA1 H338 338 244 2m32_A(0.0196) Cluster-exclusive P:1 0.0196 1 1 paad:1 ENST00000282588 6 3d ITGA1 F339 339 244 2m32_A(0.0196) Cluster-exclusive L:1 0.0196 1 1 coadread:1 ENST00000282588 6 3d THBS2 A685 685 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive E:1|V:1 0.0205 2 2 blca:1|luad:1 ENST00000366787 3 3d THBS2 E693 693 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive K:1 0.0205 1 1 lusm:1 ENST00000366787 3 3d THBS2 G699 699 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive A:1|C:1|V:1 0.0205 3 1 luad:3 ENST00000366787 3 3d THBS2 W700 700 247 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive R:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 D696 696 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive N:2 0.0205 2 1 skcm:2 ENST00000366787 3 3d THBS2 D698 698 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive E:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 G699 699 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive A:1|C:1|V:1 0.0205 3 1 luad:3 ENST00000366787 3 3d THBS2 W700 700 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive R:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 D718 718 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive N:1 0.0205 1 1 luad:1 ENST00000366787 3 3d THBS2 S726 726 248 2rhp_A(0.0205);1yo8_A(0.0285) Cluster-exclusive Y:1 0.0205 1 1 coadread:1 ENST00000366787 3 3d KRAS A11 11 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot-linked T:1 0.0207 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0207 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot A:1|R:1|C:12|D:75|V:2 0.0207 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS G60 60 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot D:1 0.0207 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0207 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS D92 92 249 1nvx_Q(0.0232);2lwi_A(0.0348);3kud_A(0.0207);6q21_A(0.023);1nvu_Q(0.0231);2lcf_A(0.0322) Hotspot-linked Y:1 0.0207 1 1 brca:1 ENST00000311936 3 3d KRAS A11 11 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot-linked T:1 0.0207 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0207 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot A:1|R:1|C:12|D:75|V:2 0.0207 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS G60 60 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot D:1 0.0207 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0207 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS E62 62 250 1nvx_Q(0.0232);3kud_A(0.0207);1nvu_Q(0.0231) Hotspot-linked G:1|K:1 0.0207 2 2 skcm:1|lihc:1 ENST00000311936 3 3d SPOP F102 102 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot C:2|V:2|L:1 0.0208 5 1 prad:5 ENST00000347630 2 3d SPOP K103 103 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot-linked N:1 0.0208 1 1 ucec:1 ENST00000347630 2 3d SPOP F104 104 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot-linked S:1|I:1 0.0208 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot-linked V:4 0.0208 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot-linked R:1|N:1 0.0208 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP W131 131 251 3hqi_B(0.0228);3hqi_A(0.0245);3hu6_A(0.0213);3hu6_B(0.0208) Hotspot R:1|S:1|C:1|G:4 0.0208 7 2 prad:6|ucec:1 ENST00000347630 2 3d NRAS G12 12 252 1nvv_Q(0.0209) Hotspot A:3|R:2|C:7|S:3|D:18|V:3 0.0209 36 7 mmyl:3|coadread:15|stad:1|laml:6|skcm:7|ucec:2|mds:2 ENST00000369535 4 3d NRAS G13 13 252 1nvv_Q(0.0209) Hotspot R:10|D:11|V:1 0.0209 22 9 mmyl:5|coadread:3|stad:1|blca:1|dlbc:1|laml:5|mbl:1|skcm:3|mds:2 ENST00000369535 4 3d NRAS P34 34 252 1nvv_Q(0.0209) Hotspot-linked L:1 0.0209 1 1 skcm:1 ENST00000369535 4 3d NRAS G60 60 252 1nvv_Q(0.0209) Hotspot-linked 0.0209 1 ENST00000369535 4 3d NRAS Q61 61 252 1nvv_Q(0.0209) Hotspot P:1|R:113|H:16|K:73|L:27 0.0209 230 17 acc:1|mmyl:27|npc:1|coadread:16|cll:4|thca:34|laml:6|blca:3|ov:2|lihc:1|lgg:1|kich:1|stad:2|gbm:1|skcm:122|ucec:4|luad:4 ENST00000369535 4 3d BRAF G466 466 253 4ehg_A(0.0209) Hotspot A:1|E:6|V:10 0.0209 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 253 4ehg_A(0.0209) Hotspot-linked L:2 0.0209 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 253 4ehg_A(0.0209) Hotspot A:9|R:3|S:1|E:2|V:6 0.0209 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF L485 485 253 4ehg_A(0.0209) Hotspot-linked S:1|Y:1 0.0209 2 2 skcm:1|luad:1 ENST00000288602 6 3d BRAF D594 594 253 4ehg_A(0.0209) Hotspot G:6|H:1|N:5 0.0209 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF L597 597 253 4ehg_A(0.0209) Hotspot Q:2|R:1|S:1 0.0209 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d TP53 C238 238 260 2x0w_B(0.0217) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0217 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 260 2x0w_B(0.0217) Hotspot-linked R:1|G:2 0.0217 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 260 2x0w_B(0.0217) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0217 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 260 2x0w_B(0.0217) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0217 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 260 2x0w_B(0.0217) Hotspot-linked R:2|V:3|I:5 0.0217 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 260 2x0w_B(0.0217) Hotspot-linked I:4 0.0217 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 260 2x0w_B(0.0217) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0217 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 260 2x0w_B(0.0217) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0217 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 V272 272 260 2x0w_B(0.0217) Hotspot E:1|G:4|K:1|L:1|M:17 0.0217 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 260 2x0w_B(0.0217) Hotspot P:4|C:119|S:5|H:103|L:22 0.0217 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 260 2x0w_B(0.0217) Hotspot A:4|D:5|F:7|G:4|L:1 0.0217 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 260 2x0w_B(0.0217) Hotspot R:1|S:4|F:10|Y:15 0.0217 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d BRAF G466 466 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot A:1|E:6|V:10 0.0219 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot-linked L:2 0.0219 2 1 skcm:2 ENST00000288602 6 3d BRAF N581 581 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot S:7|T:2|H:1|I:1 0.0219 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot G:6|H:1|N:5 0.0219 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot-linked L:1 0.0219 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot R:2|S:1|D:1|V:1 0.0219 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 262 4dbn_B(0.0222);4ksq_B(0.0219) Hotspot Q:2|R:1|S:1 0.0219 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d TP53 C238 238 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0221 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot S:8|D:6|T:1 0.0221 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot-linked R:1|G:2 0.0221 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0221 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0221 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot-linked R:2|V:3|I:5 0.0221 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot-linked I:4 0.0221 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0221 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0221 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 P250 250 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot-linked L:12 0.0221 12 9 paad:1|coadread:1|kich:1|stad:1|ov:2|gbc:1|lusc:1|lgg:2|luad:2 ENST00000269305 4 3d TP53 I251 251 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot-linked S:2|F:1|N:3 0.0221 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V272 272 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot E:1|G:4|K:1|L:1|M:17 0.0221 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot P:4|C:119|S:5|H:103|L:22 0.0221 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 265 1tsr_C(0.0238);1tup_C(0.0221) Hotspot A:4|D:5|F:7|G:4|L:1 0.0221 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d PTEN D24 24 266 1d5r_A(0.0223) Cluster-exclusive E:1|V:1|G:1|H:1|N:1 0.0223 5 4 brca:1|stad:2|ucs:1|ucec:1 ENST00000371953 3 3d PTEN M35 35 266 1d5r_A(0.0223) Hotspot-linked I:1 0.0223 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 266 1d5r_A(0.0223) Hotspot-linked R:2|E:1 0.0223 3 1 gbm:3 ENST00000371953 3 3d PTEN C124 124 266 1d5r_A(0.0223) Hotspot-linked R:1|S:1|G:1 0.0223 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN K125 125 266 1d5r_A(0.0223) Hotspot-linked T:1|N:1 0.0223 2 2 coadread:1|kirc:1 ENST00000371953 3 3d PTEN A126 126 266 1d5r_A(0.0223) Hotspot-linked S:1|D:2|V:1|G:1 0.0223 5 5 brca:1|stad:1|gbm:1|ucs:1|ucec:1 ENST00000371953 3 3d PTEN G127 127 266 1d5r_A(0.0223) Hotspot-linked R:3|E:1|V:1 0.0223 5 3 stad:1|skcm:1|ucec:3 ENST00000371953 3 3d PTEN K128 128 266 1d5r_A(0.0223) Hotspot-linked Q:2|N:3 0.0223 5 5 brca:1|prad:1|skcm:1|ucec:1|lusc:1 ENST00000371953 3 3d EP300 D1399 1399 268 4bhw_B(0.0228);4bhw_A(0.0245) Hotspot Y:2|N:16 0.0228 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 H1451 1451 268 4bhw_B(0.0228);4bhw_A(0.0245) Hotspot P:1|R:1|L:1 0.0228 3 3 brca:1|blca:1|ucec:1 ENST00000263253 7 3d EP300 P1452 1452 268 4bhw_B(0.0228);4bhw_A(0.0245) Hotspot-linked F:1|L:2 0.0228 3 2 hnsc:1|cscc:2 ENST00000263253 7 3d EP300 Q1455 1455 268 4bhw_B(0.0228);4bhw_A(0.0245) Hotspot-linked R:1|H:1 0.0228 2 1 blca:2 ENST00000263253 7 3d EP300 S1642 1642 268 4bhw_B(0.0228);4bhw_A(0.0245) Hotspot-linked F:1 0.0228 1 1 skcm:1 ENST00000263253 7 3d TUBB2B A9 9 274 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4f61_H(0.0322);4i55_B(0.0524);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3ut5_B(0.0389);4drx_B(0.0295);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);2xrp_A(0.0292);2hxf_B(0.0261);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);2hxh_B(0.029);3ryc_B(0.0392);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryh_B(0.0352);3ryf_D(0.0302);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive V:1 0.0231 1 1 paad:1 ENST00000259818 7 3d TUBB2B C12 12 274 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4f61_H(0.0322);4i55_B(0.0524);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3ut5_B(0.0389);4drx_B(0.0295);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);2xrp_A(0.0292);2hxf_B(0.0261);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);2hxh_B(0.029);3ryc_B(0.0392);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryh_B(0.0352);3ryf_D(0.0302);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive G:1 0.0231 1 1 brca:1 ENST00000259818 7 3d TUBB2B G13 13 274 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4f61_H(0.0322);4i55_B(0.0524);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3ut5_B(0.0389);4drx_B(0.0295);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);2xrp_A(0.0292);2hxf_B(0.0261);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);2hxh_B(0.029);3ryc_B(0.0392);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryh_B(0.0352);3ryf_D(0.0302);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive C:1 0.0231 1 1 lihc:1 ENST00000259818 7 3d TUBB2B N14 14 274 4f6r_B(0.0305);4f61_B(0.0406);4hna_B(0.0324);4f61_H(0.0322);4i55_B(0.0524);2wbe_B(0.0281);4i55_D(0.0674);4ihj_D(0.066);3iz0_B(0.0258);4i50_D(0.0633);4drx_D(0.0326);3ut5_B(0.0389);4drx_B(0.0295);4ihj_B(0.0499);4i50_B(0.0537);3edl_B(0.0324);2xrp_A(0.0292);2hxf_B(0.0261);4i4t_B(0.0455);4i4t_D(0.0648);3ryc_D(0.031);3j2u_B(0.0298);3ryf_B(0.0393);2hxh_B(0.029);3ryc_B(0.0392);1tvk_B(0.0273);4iij_B(0.0505);2p4n_B(0.0272);4iij_D(0.0682);4eb6_B(0.0352);3ryi_B(0.0275);3ryh_D(0.0291);3ryh_B(0.0352);3ryf_D(0.0302);3dco_B(0.0271);3e22_B(0.0231);4atu_A(0.0292);4atx_A(0.0276);4abo_A(0.0248);1jff_B(0.0276) Cluster-exclusive S:1 0.0231 1 1 kirc:1 ENST00000259818 7 3d PCDHB13 R530 530 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive C:1|H:3|L:1 0.0232 5 5 acc:1|coadread:1|esca:1|ov:1|luad:1 ENST00000341948 4 3d PCDHB13 S534 534 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive T:1 0.0232 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 D535 535 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive E:1 0.0232 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 G537 537 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive V:1 0.0232 1 1 paad:1 ENST00000341948 4 3d PCDHB13 S538 538 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive F:1 0.0232 1 1 skcm:1 ENST00000341948 4 3d PCDHB13 P539 539 275 4bba_A(0.0232);4bb9_A(0.0257) Cluster-exclusive L:1 0.0232 1 1 luad:1 ENST00000341948 4 3d KRAS A11 11 277 1xj0_A(0.0234) Hotspot-linked T:1 0.0234 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 277 1xj0_A(0.0234) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0234 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 277 1xj0_A(0.0234) Hotspot A:1|R:1|C:12|D:75|V:2 0.0234 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS Q61 61 277 1xj0_A(0.0234) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0234 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d KRAS D92 92 277 1xj0_A(0.0234) Hotspot-linked Y:1 0.0234 1 1 brca:1 ENST00000311936 3 3d PIK3R1 D560 560 278 4l2y_B(0.0298);2v1y_B(0.0312);4l1b_B(0.0315);3hiz_B(0.0266);3hhm_B(0.0288);4waf_B(0.0235) Hotspot-linked G:2|H:2|N:1 0.0235 5 4 gbm:2|hnsc:1|lgg:1|luad:1 ENST00000274335 5 3d PIK3R1 N564 564 278 4l2y_B(0.0298);2v1y_B(0.0312);4l1b_B(0.0315);3hiz_B(0.0266);3hhm_B(0.0288);4waf_B(0.0235) Hotspot D:6 0.0235 6 4 coadread:2|skcm:1|ucec:1|lgg:2 ENST00000274335 5 3d PIK3R1 S565 565 278 4l2y_B(0.0298);2v1y_B(0.0312);4l1b_B(0.0315);3hiz_B(0.0266);3hhm_B(0.0288);4waf_B(0.0235) Hotspot-linked R:1|N:1 0.0235 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 278 4l2y_B(0.0298);2v1y_B(0.0312);4l1b_B(0.0315);3hiz_B(0.0266);3hhm_B(0.0288);4waf_B(0.0235) Hotspot E:5 0.0235 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 278 4l2y_B(0.0298);2v1y_B(0.0312);4l1b_B(0.0315);3hiz_B(0.0266);3hhm_B(0.0288);4waf_B(0.0235) Hotspot-linked T:1 0.0235 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 Y452 452 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Cluster-exclusive C:2|H:1|N:1 0.0237 4 3 esca:1|hnsc:1|ucec:2 ENST00000274335 5 3d PIK3R1 K459 459 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked E:1 0.0237 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 D569 569 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked G:1 0.0237 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked P:1 0.0237 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked R:1 0.0237 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked P:3 0.0237 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Hotspot-linked T:1|I:2 0.0237 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d PIK3R1 T576 576 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Cluster-exclusive M:1 0.0237 1 1 esca:1 ENST00000274335 5 3d PIK3R1 R577 577 279 4ovu_B(0.0364);4l2y_B(0.0299);2v1y_B(0.0516);4l23_B(0.0343);4a55_B(0.0571);3hhm_B(0.0291);4waf_B(0.0237) Cluster-exclusive G:1 0.0237 1 1 lihc:1 ENST00000274335 5 3d NGFR V71 71 281 1sg1_X(0.0258);3ij2_Y(0.0239);3ij2_X(0.0242);3buk_C(0.024) Cluster-exclusive M:1 0.0239 1 1 stad:1 ENST00000172229 3 3d NGFR T72 72 281 1sg1_X(0.0258);3ij2_Y(0.0239);3ij2_X(0.0242);3buk_C(0.024) Cluster-exclusive M:2 0.0239 2 2 paad:1|skcm:1 ENST00000172229 3 3d NGFR F73 73 281 1sg1_X(0.0258);3ij2_Y(0.0239);3ij2_X(0.0242);3buk_C(0.024) Cluster-exclusive L:1 0.0239 1 1 coadread:1 ENST00000172229 3 3d NGFR P85 85 281 1sg1_X(0.0258);3ij2_Y(0.0239);3ij2_X(0.0242);3buk_C(0.024) Cluster-exclusive L:2 0.0239 2 2 mbl:1|skcm:1 ENST00000172229 3 3d NGFR D104 104 281 1sg1_X(0.0258);3ij2_Y(0.0239);3ij2_X(0.0242);3buk_C(0.024) Cluster-exclusive N:2 0.0239 2 2 acc:1|luad:1 ENST00000172229 3 3d STIM1 H72 72 282 2k60_A(0.0241) Cluster-exclusive R:1 0.0241 1 1 luad:1 ENST00000300737 4 3d STIM1 D78 78 282 2k60_A(0.0241) Cluster-exclusive G:1 0.0241 1 1 skcm:1 ENST00000300737 4 3d STIM1 D82 82 282 2k60_A(0.0241) Cluster-exclusive N:1 0.0241 1 1 cscc:1 ENST00000300737 4 3d STIM1 V83 83 282 2k60_A(0.0241) Cluster-exclusive A:1 0.0241 1 1 skcm:1 ENST00000300737 4 3d STIM1 S116 116 282 2k60_A(0.0241) Cluster-exclusive N:1 0.0241 1 1 gbm:1 ENST00000300737 4 3d TUBA3D D396 396 284 4aqv_A(0.0245);4aqw_A(0.0244) Cluster-exclusive N:2 0.0244 2 2 coadread:1|skcm:1 ENST00000321253 6 3d TUBA3D M398 398 284 4aqv_A(0.0245);4aqw_A(0.0244) Cluster-exclusive V:1 0.0244 1 1 stad:1 ENST00000321253 6 3d TUBA3D Y399 399 284 4aqv_A(0.0245);4aqw_A(0.0244) Cluster-exclusive S:1 0.0244 1 1 luad:1 ENST00000321253 6 3d TUBA3D R402 402 284 4aqv_A(0.0245);4aqw_A(0.0244) Cluster-exclusive Q:1 0.0244 1 1 luad:1 ENST00000321253 6 3d SPOP Y87 87 287 2cr2_A(0.025) Hotspot S:2|C:1|N:2 0.025 5 1 prad:5 ENST00000347630 2 3d SPOP F104 104 287 2cr2_A(0.025) Hotspot-linked S:1|I:1 0.025 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 287 2cr2_A(0.025) Hotspot-linked V:4 0.025 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP W131 131 287 2cr2_A(0.025) Hotspot R:1|S:1|C:1|G:4 0.025 7 2 prad:6|ucec:1 ENST00000347630 2 3d SPOP F133 133 287 2cr2_A(0.025) Hotspot S:3|C:4|V:4|I:2|L:9 0.025 22 1 prad:22 ENST00000347630 2 3d SPOP K134 134 287 2cr2_A(0.025) Hotspot-linked N:1 0.025 1 1 prad:1 ENST00000347630 2 3d PPP2R1A P179 179 288 2ie4_A(0.0272);2pf4_B(0.0285);2pf4_A(0.0279);3dw8_D(0.0286);2nyl_A(0.0312);3dw8_A(0.0308);2npp_A(0.0286);2nym_A(0.0292);4i5l_D(0.0281);2nym_D(0.0287);4i5n_A(0.0281);1b3u_B(0.0276);2nyl_D(0.0292);4i5n_D(0.0263);1b3u_A(0.0296);2pkg_A(0.0285);2pkg_B(0.0277);4i5l_A(0.0311);2npp_D(0.0297);2iae_A(0.0251);3fga_A(0.0277);2pf4_C(0.0302) Hotspot R:12|L:1 0.0251 13 2 ucs:5|ucec:8 ENST00000322088 6 3d PPP2R1A R182 182 288 2ie4_A(0.0272);2pf4_B(0.0285);2pf4_A(0.0279);3dw8_D(0.0286);2nyl_A(0.0312);3dw8_A(0.0308);2npp_A(0.0286);2nym_A(0.0292);4i5l_D(0.0281);2nym_D(0.0287);4i5n_A(0.0281);1b3u_B(0.0276);2nyl_D(0.0292);4i5n_D(0.0263);1b3u_A(0.0296);2pkg_A(0.0285);2pkg_B(0.0277);4i5l_A(0.0311);2npp_D(0.0297);2iae_A(0.0251);3fga_A(0.0277);2pf4_C(0.0302) Hotspot-linked W:1 0.0251 1 1 stad:1 ENST00000322088 6 3d PPP2R1A R183 183 288 2ie4_A(0.0272);2pf4_B(0.0285);2pf4_A(0.0279);3dw8_D(0.0286);2nyl_A(0.0312);3dw8_A(0.0308);2npp_A(0.0286);2nym_A(0.0292);4i5l_D(0.0281);2nym_D(0.0287);4i5n_A(0.0281);1b3u_B(0.0276);2nyl_D(0.0292);4i5n_D(0.0263);1b3u_A(0.0296);2pkg_A(0.0285);2pkg_B(0.0277);4i5l_A(0.0311);2npp_D(0.0297);2iae_A(0.0251);3fga_A(0.0277);2pf4_C(0.0302) Hotspot Q:4|W:14|G:1 0.0251 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A Q217 217 288 2ie4_A(0.0272);2pf4_B(0.0285);2pf4_A(0.0279);3dw8_D(0.0286);2nyl_A(0.0312);3dw8_A(0.0308);2npp_A(0.0286);2nym_A(0.0292);4i5l_D(0.0281);2nym_D(0.0287);4i5n_A(0.0281);1b3u_B(0.0276);2nyl_D(0.0292);4i5n_D(0.0263);1b3u_A(0.0296);2pkg_A(0.0285);2pkg_B(0.0277);4i5l_A(0.0311);2npp_D(0.0297);2iae_A(0.0251);3fga_A(0.0277);2pf4_C(0.0302) Hotspot-linked K:1 0.0251 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A V220 220 288 2ie4_A(0.0272);2pf4_B(0.0285);2pf4_A(0.0279);3dw8_D(0.0286);2nyl_A(0.0312);3dw8_A(0.0308);2npp_A(0.0286);2nym_A(0.0292);4i5l_D(0.0281);2nym_D(0.0287);4i5n_A(0.0281);1b3u_B(0.0276);2nyl_D(0.0292);4i5n_D(0.0263);1b3u_A(0.0296);2pkg_A(0.0285);2pkg_B(0.0277);4i5l_A(0.0311);2npp_D(0.0297);2iae_A(0.0251);3fga_A(0.0277);2pf4_C(0.0302) Hotspot-linked M:1 0.0251 1 1 ucec:1 ENST00000322088 6 3d GPT2 A131 131 293 3ihj_A(0.0258) Cluster-exclusive S:1|D:1 0.0258 2 1 lihc:2 ENST00000340124 4 3d GPT2 K132 132 293 3ihj_A(0.0258) Cluster-exclusive N:1 0.0258 1 1 ucec:1 ENST00000340124 4 3d GPT2 K133 133 293 3ihj_A(0.0258) Cluster-exclusive Q:1 0.0258 1 1 coadread:1 ENST00000340124 4 3d GPT2 R134 134 293 3ihj_A(0.0258) Cluster-exclusive H:1 0.0258 1 1 ucec:1 ENST00000340124 4 3d GPT2 R136 136 293 3ihj_A(0.0258) Cluster-exclusive Q:1|L:1 0.0258 2 2 esca:1|hnsc:1 ENST00000340124 4 3d DPP6 A303 303 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:2 0.0264 2 2 stad:1|esca:1 ENST00000377770 3 3d DPP6 W305 305 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive L:1 0.0264 1 1 lusc:1 ENST00000377770 3 3d DPP6 A314 314 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:1 0.0264 1 1 stad:1 ENST00000377770 3 3d DPP6 Y315 315 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive C:1 0.0264 1 1 gbm:1 ENST00000377770 3 3d DPP6 A316 316 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:1 0.0264 1 1 hnsc:1 ENST00000377770 3 3d DPP6 A317 317 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive T:2 0.0264 2 2 cll:1|cesc:1 ENST00000377770 3 3d DPP6 S355 355 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive F:1 0.0264 1 1 skcm:1 ENST00000377770 3 3d DPP6 L356 356 296 1xfd_B(0.0294);1xfd_C(0.0264);1xfd_D(0.0324);1xfd_A(0.0275) Cluster-exclusive Q:1 0.0264 1 1 lusc:1 ENST00000377770 3 3d TP53 V173 173 298 2fej_A(0.0265) Hotspot A:2|E:1|G:2|L:15|M:12 0.0265 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R175 175 298 2fej_A(0.0265) Hotspot C:4|G:7|H:143 0.0265 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 298 2fej_A(0.0265) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0265 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 298 2fej_A(0.0265) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0265 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 L194 194 298 2fej_A(0.0265) Hotspot P:2|R:15|F:3|H:3 0.0265 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 298 2fej_A(0.0265) Hotspot V:3|I:17|K:4 0.0265 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 298 2fej_A(0.0265) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0265 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 298 2fej_A(0.0265) Hotspot S:8|D:6|T:1 0.0265 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 298 2fej_A(0.0265) Hotspot-linked R:1|G:2 0.0265 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 298 2fej_A(0.0265) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0265 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G245 245 298 2fej_A(0.0265) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0265 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 298 2fej_A(0.0265) Hotspot-linked R:2|V:3|I:5 0.0265 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 V274 274 298 2fej_A(0.0265) Hotspot A:4|D:5|F:7|G:4|L:1 0.0265 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d PIK3R1 K459 459 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked E:1 0.0268 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 S565 565 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked R:1|N:1 0.0268 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot E:5 0.0268 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked T:1 0.0268 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 D569 569 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked G:1 0.0268 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked P:1 0.0268 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked R:1 0.0268 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked P:3 0.0268 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 301 4ovu_B(0.0319);4l2y_B(0.0268);2v1y_B(0.0388);4l1b_B(0.0295) Hotspot-linked T:1|I:2 0.0268 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d H3C10 A2 2 304 2kwk_B(0.027) Cluster-exclusive S:1|V:1|G:1 0.027 3 3 acc:1|brca:1|mmyl:1 ENST00000369163 2 3d H3C10 T4 4 304 2kwk_B(0.027) Cluster-exclusive A:1 0.027 1 1 lusm:1 ENST00000369163 2 3d H3C10 K5 5 304 2kwk_B(0.027) Cluster-exclusive M:1 0.027 1 1 hnsc:1 ENST00000369163 2 3d H3C10 Q6 6 304 2kwk_B(0.027) Cluster-exclusive H:2 0.027 2 2 hnsc:1|luad:1 ENST00000369163 2 3d BRAF G466 466 305 2fb8_A(0.0271);3prf_B(0.0271);4h58_C(0.0289);3prf_A(0.0274) Hotspot A:1|E:6|V:10 0.0271 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 305 2fb8_A(0.0271);3prf_B(0.0271);4h58_C(0.0289);3prf_A(0.0274) Hotspot-linked L:2 0.0271 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 305 2fb8_A(0.0271);3prf_B(0.0271);4h58_C(0.0289);3prf_A(0.0274) Hotspot A:9|R:3|S:1|E:2|V:6 0.0271 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF D594 594 305 2fb8_A(0.0271);3prf_B(0.0271);4h58_C(0.0289);3prf_A(0.0274) Hotspot G:6|H:1|N:5 0.0271 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF G596 596 305 2fb8_A(0.0271);3prf_B(0.0271);4h58_C(0.0289);3prf_A(0.0274) Hotspot R:2|S:1|D:1|V:1 0.0271 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d MAPK1 D321 321 306 4gsb_A(0.0271) Hotspot-linked V:1|N:2 0.0271 3 3 hnsc:1|skcm:1|cesc:1 ENST00000215832 6 3d MAPK1 E322 322 306 4gsb_A(0.0271) Hotspot K:15 0.0271 15 3 blca:1|hnsc:7|cesc:7 ENST00000215832 6 3d KRAS A11 11 308 2lwi_A(0.0273) Hotspot-linked T:1 0.0273 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 308 2lwi_A(0.0273) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0273 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 308 2lwi_A(0.0273) Hotspot A:1|R:1|C:12|D:75|V:2 0.0273 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d KRAS A59 59 308 2lwi_A(0.0273) Hotspot-linked T:1|E:1|G:3 0.0273 5 4 mmyl:2|stad:1|laml:1|kirc:1 ENST00000311936 3 3d KRAS G60 60 308 2lwi_A(0.0273) Hotspot D:1 0.0273 1 1 cscc:1 ENST00000311936 3 3d KRAS Q61 61 308 2lwi_A(0.0273) Hotspot P:1|R:11|E:1|H:44|K:10|L:8 0.0273 75 13 mmyl:15|paad:24|coadread:11|cll:1|thca:3|blca:3|laml:1|lihc:1|lusc:1|stad:3|skcm:2|ucec:3|luad:7 ENST00000311936 3 3d RBP2 E18 18 309 4efg_B(0.0371);4ede_A(0.0357);4ede_B(0.0339);4efg_A(0.0389);4qzu_D(0.0648);4qzt_D(0.0572);4qzu_C(0.0553);4gkc_A(0.0303);4qzt_A(0.0628);4qzt_C(0.0589);4qzu_B(0.0607);4qzt_B(0.0608);4qzu_A(0.062);4gkc_B(0.0321);4ruu_B(0.0478);4ruu_A(0.0438);4eej_A(0.03);4eej_B(0.0273);4qyp_D(0.0558);2rct_A(0.0582);4qyp_C(0.0571);4exz_A(0.0412);2rcq_A(0.0601);4qyn_B(0.0531);4qyn_A(0.0595);4qyp_B(0.0615);4qyp_A(0.0616);1opb_A(0.0337);1opa_A(0.0357) Cluster-exclusive D:1|G:1 0.0273 2 2 gbm:1|kirp:1 ENST00000232217 2 3d RBP2 M21 21 309 4efg_B(0.0371);4ede_A(0.0357);4ede_B(0.0339);4efg_A(0.0389);4qzu_D(0.0648);4qzt_D(0.0572);4qzu_C(0.0553);4gkc_A(0.0303);4qzt_A(0.0628);4qzt_C(0.0589);4qzu_B(0.0607);4qzt_B(0.0608);4qzu_A(0.062);4gkc_B(0.0321);4ruu_B(0.0478);4ruu_A(0.0438);4eej_A(0.03);4eej_B(0.0273);4qyp_D(0.0558);2rct_A(0.0582);4qyp_C(0.0571);4exz_A(0.0412);2rcq_A(0.0601);4qyn_B(0.0531);4qyn_A(0.0595);4qyp_B(0.0615);4qyp_A(0.0616);1opb_A(0.0337);1opa_A(0.0357) Cluster-exclusive K:1|L:1 0.0273 2 1 stad:2 ENST00000232217 2 3d RBP2 A23 23 309 4efg_B(0.0371);4ede_A(0.0357);4ede_B(0.0339);4efg_A(0.0389);4qzu_D(0.0648);4qzt_D(0.0572);4qzu_C(0.0553);4gkc_A(0.0303);4qzt_A(0.0628);4qzt_C(0.0589);4qzu_B(0.0607);4qzt_B(0.0608);4qzu_A(0.062);4gkc_B(0.0321);4ruu_B(0.0478);4ruu_A(0.0438);4eej_A(0.03);4eej_B(0.0273);4qyp_D(0.0558);2rct_A(0.0582);4qyp_C(0.0571);4exz_A(0.0412);2rcq_A(0.0601);4qyn_B(0.0531);4qyn_A(0.0595);4qyp_B(0.0615);4qyp_A(0.0616);1opb_A(0.0337);1opa_A(0.0357) Cluster-exclusive S:1|T:1 0.0273 2 2 paad:1|lusc:1 ENST00000232217 2 3d RBP2 I26 26 309 4efg_B(0.0371);4ede_A(0.0357);4ede_B(0.0339);4efg_A(0.0389);4qzu_D(0.0648);4qzt_D(0.0572);4qzu_C(0.0553);4gkc_A(0.0303);4qzt_A(0.0628);4qzt_C(0.0589);4qzu_B(0.0607);4qzt_B(0.0608);4qzu_A(0.062);4gkc_B(0.0321);4ruu_B(0.0478);4ruu_A(0.0438);4eej_A(0.03);4eej_B(0.0273);4qyp_D(0.0558);2rct_A(0.0582);4qyp_C(0.0571);4exz_A(0.0412);2rcq_A(0.0601);4qyn_B(0.0531);4qyn_A(0.0595);4qyp_B(0.0615);4qyp_A(0.0616);1opb_A(0.0337);1opa_A(0.0357) Cluster-exclusive T:1 0.0273 1 1 blca:1 ENST00000232217 2 3d ZNF98 S363 363 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive F:1 0.0275 1 1 skcm:1 ENST00000357774 5 3d ZNF98 H364 364 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive Y:1 0.0275 1 1 skcm:1 ENST00000357774 5 3d ZNF98 T366 366 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive A:1|N:1 0.0275 2 2 skcm:1|luad:1 ENST00000357774 5 3d ZNF98 T367 367 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive I:1 0.0275 1 1 ucec:1 ENST00000357774 5 3d ZNF98 K369 369 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive T:1 0.0275 1 1 stad:1 ENST00000357774 5 3d ZNF98 R370 370 311 3dgc_L(0.0287);3g9v_D(0.0432);1ykb_A(0.0319);1ykb_B(0.0275);3g9v_B(0.0453);1m4r_A(0.0357);1m4r_B(0.0318);3dlq_I(0.0291) Cluster-exclusive I:3|K:1 0.0275 4 2 skcm:1|ucec:3 ENST00000357774 5 3d TP53 C238 238 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0276 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot-linked R:1|G:2 0.0276 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0276 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0276 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot-linked R:2|V:3|I:5 0.0276 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot-linked I:4 0.0276 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0276 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0276 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 V272 272 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot E:1|G:4|K:1|L:1|M:17 0.0276 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot P:4|C:119|S:5|H:103|L:22 0.0276 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 312 1uol_A(0.0336);2j21_B(0.0307);2j21_A(0.034);1uol_B(0.039);2x0u_A(0.0306);2x0u_B(0.0339);2x0v_A(0.0355);2x0v_B(0.0348);2x0w_A(0.0347);4agn_B(0.0315);4ago_A(0.0276);4agm_B(0.0337);4agn_A(0.0313);4agl_B(0.035);4agm_A(0.0312);4agl_A(0.0331);4agq_B(0.0347);2vuk_B(0.0327);4agq_A(0.0345);4agp_B(0.0303);2vuk_A(0.0311);4ago_B(0.0304);4agp_A(0.03);2j1w_A(0.0355);2j1x_A(0.0327);2j1w_B(0.033);2j1y_A(0.0312);2j1x_B(0.0369);2j1y_B(0.0366);2j1z_A(0.0333);2j1y_C(0.0335);2j1z_B(0.0318);2j1y_D(0.0355);4loe_B(0.0361);4lof_A(0.037);3zme_A(0.0337);4loe_A(0.0366);4loe_D(0.0388);4loe_C(0.0374);3zme_B(0.0298);2wgx_B(0.0348);2wgx_A(0.0325);2bin_A(0.0312) Hotspot A:4|D:5|F:7|G:4|L:1 0.0276 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 L137 137 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot-linked Q:1 0.0284 1 1 hnsc:1 ENST00000269305 4 3d TP53 R174 174 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot-linked S:1|W:2|K:1 0.0284 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot C:4|G:7|H:143 0.0284 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0284 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0284 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 L194 194 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot P:2|R:15|F:3|H:3 0.0284 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 Y236 236 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot C:16|D:2|N:2 0.0284 20 11 brca:1|paad:1|coadread:1|prad:1|stad:1|hnsc:6|ov:2|lusc:1|lgg:3|luad:2|cscc:1 ENST00000269305 4 3d TP53 M237 237 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot V:3|I:17|K:4 0.0284 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0284 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot S:8|D:6|T:1 0.0284 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot-linked R:1|G:2 0.0284 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0284 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G245 245 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0284 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot-linked R:2|V:3|I:5 0.0284 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 V274 274 318 4ibz_B(0.0333);4ijt_A(0.0284);4ibq_B(0.0311);2ocj_B(0.0349) Hotspot A:4|D:5|F:7|G:4|L:1 0.0284 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d EPHB1 H742 742 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive N:1 0.0286 1 1 skcm:1 ENST00000398015 3 3d EPHB1 R743 743 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive Q:1 0.0286 1 1 stad:1 ENST00000398015 3 3d EPHB1 D744 744 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive Y:1|N:1 0.0286 2 2 cscc:1|luad:1 ENST00000398015 3 3d EPHB1 D762 762 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive E:1|N:4 0.0286 5 4 stad:1|gbm:1|skcm:2|ucec:1 ENST00000398015 3 3d EPHB1 D806 806 321 3zfx_D(0.0296);3zfx_E(0.0292);3zfx_B(0.0308);3zfx_A(0.0312);3zfx_H(0.0286) Cluster-exclusive N:2 0.0286 2 2 coadread:1|stad:1 ENST00000398015 3 3d TGFBI T504 504 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive N:1 0.029 1 1 ucec:1 ENST00000442011 2 3d TGFBI V505 505 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive F:1 0.029 1 1 esca:1 ENST00000442011 2 3d TGFBI D507 507 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive V:1 0.029 1 1 ucec:1 ENST00000442011 2 3d TGFBI V508 508 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive I:1 0.029 1 1 luad:1 ENST00000442011 2 3d TGFBI L509 509 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive P:2 0.029 2 2 coadread:1|lihc:1 ENST00000442011 2 3d TGFBI L531 531 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive V:1 0.029 1 1 hnsc:1 ENST00000442011 2 3d TGFBI T621 621 325 2ltb_A(0.029);2ltc_A(0.0382) Cluster-exclusive P:1 0.029 1 1 skcm:1 ENST00000442011 2 3d HDAC8 M40 40 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive V:1 0.0294 1 1 luad:1 ENST00000373573 3 3d HDAC8 L44 44 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive F:1 0.0294 1 1 luad:1 ENST00000373573 3 3d HDAC8 P332 332 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive Q:1 0.0294 1 1 skcm:1 ENST00000373573 3 3d HDAC8 H334 334 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive Y:1 0.0294 1 1 thca:1 ENST00000373573 3 3d HDAC8 F336 336 328 3f0r_B(0.0339);3f07_C(0.0294);3f07_B(0.0314);3mz6_A(0.0336);3f07_A(0.0357);3mz4_A(0.0365);3mz3_B(0.0311);3mz3_A(0.0323);1vkg_B(0.0949);1vkg_A(0.0976);3sfh_A(0.0315);4rn1_B(0.033);4qa5_B(0.0305);3rqd_A(0.0349);4rn0_B(0.0359);4rn0_A(0.0311);3rqd_B(0.0369);1t64_B(0.039);1t67_A(0.0402) Cluster-exclusive L:1 0.0294 1 1 coadread:1 ENST00000373573 3 3d TP53 Y163 163 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot C:27|D:2|H:4|N:4 0.03 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 V173 173 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot A:2|E:1|G:2|L:15|M:12 0.03 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot-linked S:1|W:2|K:1 0.03 4 1 lihc:4 ENST00000269305 4 3d TP53 L194 194 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot P:2|R:15|F:3|H:3 0.03 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 C238 238 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot R:3|S:3|F:12|G:1|Y:15 0.03 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot S:8|D:6|T:1 0.03 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot-linked R:1|G:2 0.03 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot P:3|A:2|C:6|F:19|Y:9 0.03 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot S:5|F:13|G:1|W:1|Y:3 0.03 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot R:1|C:8|S:5|D:9|V:2 0.03 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.03 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot-linked R:2|V:3|I:5 0.03 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot-linked I:4 0.03 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot P:5|Q:108|W:89|G:2|L:10 0.03 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.03 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot-linked S:2|F:1|N:3 0.03 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V274 274 330 1tsr_C(0.0473);3q06_A(0.03);1tup_C(0.0473) Hotspot A:4|D:5|F:7|G:4|L:1 0.03 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d RBBP7 S314 314 331 2xu7_A(0.03) Cluster-exclusive Y:1 0.03 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 331 2xu7_A(0.03) Cluster-exclusive Y:1 0.03 1 1 skcm:1 ENST00000380087 2 3d RBBP7 G336 336 331 2xu7_A(0.03) Cluster-exclusive D:1 0.03 1 1 stad:1 ENST00000380087 2 3d RBBP7 R340 340 331 2xu7_A(0.03) Cluster-exclusive C:1|H:2 0.03 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 331 2xu7_A(0.03) Cluster-exclusive T:1|H:1 0.03 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d SOX6 E104 104 332 4jra_D(0.0306) Cluster-exclusive D:1 0.0306 1 1 luad:1 ENST00000528429 1 3d SOX6 R122 122 332 4jra_D(0.0306) Cluster-exclusive C:3|H:1 0.0306 4 4 coadread:1|prad:1|ucs:1|lusc:1 ENST00000528429 1 3d SOX6 R123 123 332 4jra_D(0.0306) Cluster-exclusive S:1|C:1|H:1 0.0306 3 3 paad:1|skcm:1|lihc:1 ENST00000528429 1 3d SOX6 R144 144 332 4jra_D(0.0306) Cluster-exclusive Q:1 0.0306 1 1 coadread:1 ENST00000528429 1 3d SOX6 R122 122 333 4jra_D(0.0306) Cluster-exclusive C:3|H:1 0.0306 4 4 coadread:1|prad:1|ucs:1|lusc:1 ENST00000528429 1 3d SOX6 R123 123 333 4jra_D(0.0306) Cluster-exclusive S:1|C:1|H:1 0.0306 3 3 paad:1|skcm:1|lihc:1 ENST00000528429 1 3d SOX6 E140 140 333 4jra_D(0.0306) Cluster-exclusive D:1 0.0306 1 1 stad:1 ENST00000528429 1 3d SOX6 R144 144 333 4jra_D(0.0306) Cluster-exclusive Q:1 0.0306 1 1 coadread:1 ENST00000528429 1 3d PLEKHH2 E92 92 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive K:1 0.0308 1 1 skcm:1 ENST00000282406 4 3d PLEKHH2 D99 99 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive Y:1 0.0308 1 1 coadread:1 ENST00000282406 4 3d PLEKHH2 D100 100 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive N:1 0.0308 1 1 cesc:1 ENST00000282406 4 3d PLEKHH2 V101 101 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive I:1 0.0308 1 1 coadread:1 ENST00000282406 4 3d PLEKHH2 I102 102 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive T:1 0.0308 1 1 lihc:1 ENST00000282406 4 3d PLEKHH2 Q103 103 335 4k30_B(0.0308);4k30_A(0.0357);4k30_Y(0.0326) Cluster-exclusive P:2 0.0308 2 2 coadread:1|skcm:1 ENST00000282406 4 3d CUL5 V185 185 341 Cluster-exclusive I:1 0.0313 1 1 lusc:1 ENST00000393094 2 3d CUL5 N186 186 341 Cluster-exclusive K:1 0.0313 1 1 skcm:1 ENST00000393094 2 3d CUL5 C188 188 341 Cluster-exclusive F:1 0.0313 1 1 ov:1 ENST00000393094 2 3d CUL5 P191 191 341 Cluster-exclusive S:1 0.0313 1 1 skcm:1 ENST00000393094 2 3d CUL5 E192 192 341 Cluster-exclusive K:1 0.0313 1 1 blca:1 ENST00000393094 2 3d CUL5 K194 194 341 Cluster-exclusive T:1 0.0313 1 1 gbm:1 ENST00000393094 2 3d KDM5C F92 92 346 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 ucec:1 ENST00000375401 3 3d KDM5C W93 93 346 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 kirp:1 ENST00000375401 3 3d KDM5C P163 163 346 2yqe_A(0.0319) Cluster-exclusive S:1 0.0319 1 1 stad:1 ENST00000375401 3 3d KDM5C Q168 168 346 2yqe_A(0.0319) Cluster-exclusive L:1 0.0319 1 1 lusc:1 ENST00000375401 3 3d H4C13 A84 84 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive T:1 0.0328 1 1 coadread:1 ENST00000355981 2 3d H4C13 M85 85 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive I:1 0.0328 1 1 brca:1 ENST00000355981 2 3d H4C13 D86 86 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive N:1 0.0328 1 1 blca:1 ENST00000355981 2 3d H4C13 V88 88 351 3an2_B(0.0328);3an2_F(0.0662) Cluster-exclusive I:1 0.0328 1 1 mmyl:1 ENST00000355981 2 3d TP53 C238 238 352 2fej_A(0.0329) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0329 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 352 2fej_A(0.0329) Hotspot S:8|D:6|T:1 0.0329 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 352 2fej_A(0.0329) Hotspot-linked R:1|G:2 0.0329 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 352 2fej_A(0.0329) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0329 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 352 2fej_A(0.0329) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0329 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 352 2fej_A(0.0329) Hotspot-linked I:1 0.0329 1 1 ucs:1 ENST00000269305 4 3d TP53 M246 246 352 2fej_A(0.0329) Hotspot-linked R:2|V:3|I:5 0.0329 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 352 2fej_A(0.0329) Hotspot-linked I:4 0.0329 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 352 2fej_A(0.0329) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0329 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 352 2fej_A(0.0329) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0329 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 P250 250 352 2fej_A(0.0329) Hotspot-linked L:12 0.0329 12 9 paad:1|coadread:1|kich:1|stad:1|ov:2|gbc:1|lusc:1|lgg:2|luad:2 ENST00000269305 4 3d TP53 R273 273 352 2fej_A(0.0329) Hotspot P:4|C:119|S:5|H:103|L:22 0.0329 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 352 2fej_A(0.0329) Hotspot A:4|D:5|F:7|G:4|L:1 0.0329 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 352 2fej_A(0.0329) Hotspot R:1|S:4|F:10|Y:15 0.0329 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d LRRC3B G37 37 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive V:1 0.0329 1 1 luad:1 ENST00000396641 2 3d LRRC3B L39 39 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive F:2 0.0329 2 2 skcm:1|cscc:1 ENST00000396641 2 3d LRRC3B C40 40 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive W:1 0.0329 1 1 stad:1 ENST00000396641 2 3d LRRC3B S43 43 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive A:1 0.0329 1 1 lihc:1 ENST00000396641 2 3d LRRC3B P63 63 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive S:2 0.0329 2 1 skcm:2 ENST00000396641 2 3d LRRC3B P64 64 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive H:1 0.0329 1 1 lusc:1 ENST00000396641 2 3d LRRC3B E65 65 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive K:1 0.0329 1 1 skcm:1 ENST00000396641 2 3d LRRC3B L68 68 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive V:2 0.0329 2 2 stad:1|esca:1 ENST00000396641 2 3d LRRC3B S96 96 353 3kka_E(0.0329);3kka_D(0.0362) Cluster-exclusive Y:1 0.0329 1 1 luad:1 ENST00000396641 2 3d NRAS G12 12 354 1aa9_A(0.033) Hotspot A:3|R:2|C:7|S:3|D:18|V:3 0.033 36 7 mmyl:3|coadread:15|stad:1|laml:6|skcm:7|ucec:2|mds:2 ENST00000369535 4 3d NRAS G13 13 354 1aa9_A(0.033) Hotspot R:10|D:11|V:1 0.033 22 9 mmyl:5|coadread:3|stad:1|blca:1|dlbc:1|laml:5|mbl:1|skcm:3|mds:2 ENST00000369535 4 3d NRAS P34 34 354 1aa9_A(0.033) Hotspot-linked L:1 0.033 1 1 skcm:1 ENST00000369535 4 3d NRAS G60 60 354 1aa9_A(0.033) Hotspot-linked 0.033 1 ENST00000369535 4 3d NRAS Q61 61 354 1aa9_A(0.033) Hotspot P:1|R:113|H:16|K:73|L:27 0.033 230 17 acc:1|mmyl:27|npc:1|coadread:16|cll:4|thca:34|laml:6|blca:3|ov:2|lihc:1|lgg:1|kich:1|stad:2|gbm:1|skcm:122|ucec:4|luad:4 ENST00000369535 4 3d TMPRSS11E S246 246 355 2oq5_A(0.033) Cluster-exclusive F:1 0.033 1 1 cscc:1 ENST00000305363 4 3d TMPRSS11E F247 247 355 2oq5_A(0.033) Cluster-exclusive Y:1 0.033 1 1 acc:1 ENST00000305363 4 3d TMPRSS11E T250 250 355 2oq5_A(0.033) Cluster-exclusive I:1|K:1 0.033 2 2 lgg:1|luad:1 ENST00000305363 4 3d TMPRSS11E I251 251 355 2oq5_A(0.033) Cluster-exclusive T:1 0.033 1 1 lihc:1 ENST00000305363 4 3d TMPRSS11E S254 254 355 2oq5_A(0.033) Cluster-exclusive P:1|L:2 0.033 3 3 acc:1|coadread:1|ucec:1 ENST00000305363 4 3d TMPRSS11E M256 256 355 2oq5_A(0.033) Cluster-exclusive I:2 0.033 2 1 skcm:2 ENST00000305363 4 3d TUBB2B C12 12 357 4aqv_B(0.0393);4aqw_B(0.0332) Cluster-exclusive G:1 0.0332 1 1 brca:1 ENST00000259818 7 3d TUBB2B G13 13 357 4aqv_B(0.0393);4aqw_B(0.0332) Cluster-exclusive C:1 0.0332 1 1 lihc:1 ENST00000259818 7 3d TUBB2B N14 14 357 4aqv_B(0.0393);4aqw_B(0.0332) Cluster-exclusive S:1 0.0332 1 1 kirc:1 ENST00000259818 7 3d H2BC4 F71 71 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive L:1 0.0333 1 1 luad:1 ENST00000314332 5 3d H2BC4 E72 72 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive Q:2 0.0333 2 2 brca:1|blca:1 ENST00000314332 5 3d H2BC4 I74 74 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive M:1 0.0333 1 1 cesc:1 ENST00000314332 5 3d H2BC4 E77 77 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive K:2 0.0333 2 2 brca:1|cesc:1 ENST00000314332 5 3d H2BC4 A78 78 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive V:1 0.0333 1 1 coadread:1 ENST00000314332 5 3d H2BC4 S79 79 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive F:2 0.0333 2 2 brca:1|skcm:1 ENST00000314332 5 3d H2BC4 A98 98 358 2cv5_H(0.0655);3b6g_D(0.0597);2nqb_H(0.053);2nqb_D(0.0461);1hq3_F(0.0843);1f66_D(0.0606);2cv5_D(0.0635);3b6g_H(0.0492);1tzy_F(0.076);1p3b_D(0.0632);4j8v_D(0.065);3kwq_D(0.0617);1p34_H(0.0489);1p3b_H(0.0708);1p3f_D(0.084);4j8x_D(0.0666);1p34_D(0.063);3tu4_D(0.0586);1p3f_H(0.0682);1p3o_D(0.075);1p3k_H(0.0515);3kuy_D(0.062);3o62_D(0.0613);1kx3_D(0.0682);1kx5_D(0.0333);3lz1_D(0.0559);3w97_H(0.0535);3mnn_D(0.062);2fj7_D(0.0478);3w99_D(0.0621);3lz1_H(0.0547);3w97_D(0.0554);1u35_H(0.0497);3rej_H(0.0627);3rel_H(0.0534);3mvd_D(0.0589);3c1c_D(0.0686);3c1c_H(0.0516);3uta_D(0.058);3reh_D(0.0643);1m18_D(0.0655);3mgr_D(0.0669);3mgp_D(0.0605);3ut9_D(0.0553);3b6f_D(0.0469);1s32_H(0.0593);1m1a_D(0.0604);1aoi_D(0.063);3waa_D(0.0549);4ld9_H(0.0598);4ld9_D(0.0644);3b6f_H(0.0514);1s32_D(0.0606);1p3a_D(0.0685);4j8u_D(0.0599);1p3a_H(0.0596);4j8w_D(0.0664);1p3g_D(0.0635);1p3i_D(0.0598);1p3k_D(0.0685);3ut9_H(0.0546);1p3i_H(0.0534);1p3m_D(0.0752);1p3l_H(0.0572);1eqz_B(0.0965);1p3p_D(0.0662);3w98_H(0.0644);3kxb_D(0.078);3w96_H(0.0815);1zla_D(0.0689);2f8n_D(0.0576);3lz0_D(0.0578);1eqz_F(0.09);3w98_D(0.0612);1kx4_H(0.0633);3kxb_H(0.0532);3lz0_H(0.0638);2pyo_D(0.0544);1zbb_D(0.0665);3lel_D(0.0642);1zbb_H(0.0636);2aro_B(0.0751);2nzd_D(0.0641);3rek_H(0.0633);3c1b_D(0.0662);3rei_D(0.0588);1hq3_B(0.0955);3utb_H(0.0616);3c1b_H(0.0564);3mgs_D(0.0629);1m19_D(0.0612);3mgq_D(0.056);3lja_D(0.0539) Cluster-exclusive V:1 0.0333 1 1 lymbc:1 ENST00000314332 5 3d SMAD4 H92 92 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive Y:1 0.0335 1 1 cesc:1 ENST00000342988 3 3d SMAD4 Y95 95 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive C:1 0.0335 1 1 luad:1 ENST00000342988 3 3d SMAD4 A96 96 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive D:1 0.0335 1 1 paad:1 ENST00000342988 3 3d SMAD4 L109 109 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive Q:1|R:1 0.0335 2 2 brca:1|paad:1 ENST00000342988 3 3d SMAD4 C127 127 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive S:1 0.0335 1 1 paad:1 ENST00000342988 3 3d SMAD4 Y133 133 361 3qsv_C(0.0335);3qsv_D(0.0336);3qsv_A(0.0368) Cluster-exclusive N:1 0.0335 1 1 blca:1 ENST00000342988 3 3d DPYSL3 G68 68 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive A:1|E:1 0.0336 2 2 brca:1|blca:1 ENST00000398514 3 3d DPYSL3 G69 69 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive V:1 0.0336 1 1 kirc:1 ENST00000398514 3 3d DPYSL3 D71 71 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive N:2 0.0336 2 2 coadread:1|luad:1 ENST00000398514 3 3d DPYSL3 T101 101 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive I:1 0.0336 1 1 hnsc:1 ENST00000398514 3 3d DPYSL3 T102 102 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive A:1 0.0336 1 1 coadread:1 ENST00000398514 3 3d DPYSL3 R361 361 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive W:1 0.0336 1 1 brca:1 ENST00000398514 3 3d DPYSL3 M362 362 362 4bkn_A(0.0367);4cnt_A(0.0336);4bkn_B(0.0369);4cnt_D(0.0369);4cnu_A(0.0436);4cnt_B(0.0395);4cnu_B(0.0446);4cnt_C(0.0356) Cluster-exclusive L:1 0.0336 1 1 luad:1 ENST00000398514 3 3d DPYSL3 G69 69 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive V:1 0.0336 1 1 kirc:1 ENST00000398514 3 3d DPYSL3 D71 71 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive N:2 0.0336 2 2 coadread:1|luad:1 ENST00000398514 3 3d DPYSL3 T101 101 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive I:1 0.0336 1 1 hnsc:1 ENST00000398514 3 3d DPYSL3 R361 361 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive W:1 0.0336 1 1 brca:1 ENST00000398514 3 3d DPYSL3 M362 362 363 4bkn_A(0.0367);4cns_A(0.0407);4cnt_A(0.0336);4cns_B(0.0394);4bkn_B(0.0369);4cnt_D(0.0369);4cns_C(0.0406);4cnt_B(0.0395);4cnu_A(0.0436);4cnt_C(0.0356);4cns_D(0.038);4cnu_B(0.0446) Cluster-exclusive L:1 0.0336 1 1 luad:1 ENST00000398514 3 3d KDM4B E191 191 368 4lxl_A(0.0344) Cluster-exclusive K:1 0.0344 1 1 stad:1 ENST00000159111 4 3d KDM4B L195 195 368 4lxl_A(0.0344) Cluster-exclusive Q:1 0.0344 1 1 cesc:1 ENST00000159111 4 3d KDM4B Y196 196 368 4lxl_A(0.0344) Cluster-exclusive H:1 0.0344 1 1 stad:1 ENST00000159111 4 3d KDM4B S197 197 368 4lxl_A(0.0344) Cluster-exclusive N:1 0.0344 1 1 ucec:1 ENST00000159111 4 3d KDM4B P273 273 368 4lxl_A(0.0344) Cluster-exclusive S:1 0.0344 1 1 skcm:1 ENST00000159111 4 3d KDM4B F292 292 368 4lxl_A(0.0344) Cluster-exclusive V:1 0.0344 1 1 esca:1 ENST00000159111 4 3d KDM4B A293 293 368 4lxl_A(0.0344) Cluster-exclusive T:1 0.0344 1 1 coadread:1 ENST00000159111 4 3d PTK2B M537 537 370 3h3c_A(0.0345) Cluster-exclusive I:1 0.0345 1 1 ucec:1 ENST00000346049 5 3d PTK2B H547 547 370 3h3c_A(0.0345) Cluster-exclusive P:1 0.0345 1 1 luad:1 ENST00000346049 5 3d PTK2B L565 565 370 3h3c_A(0.0345) Cluster-exclusive M:1 0.0345 1 1 ucec:1 ENST00000346049 5 3d PTK2B G566 566 370 3h3c_A(0.0345) Cluster-exclusive R:1 0.0345 1 1 cll:1 ENST00000346049 5 3d PTK2B D567 567 370 3h3c_A(0.0345) Cluster-exclusive G:1 0.0345 1 1 stad:1 ENST00000346049 5 3d PTK2B L570 570 370 3h3c_A(0.0345) Cluster-exclusive F:1 0.0345 1 1 skcm:1 ENST00000346049 5 3d PTK2B M610 610 370 3h3c_A(0.0345) Cluster-exclusive I:1|L:1 0.0345 2 1 luad:2 ENST00000346049 5 3d TP53 L137 137 372 4loe_B(0.0459);2bin_A(0.035) Hotspot-linked Q:1 0.035 1 1 hnsc:1 ENST00000269305 4 3d TP53 R174 174 372 4loe_B(0.0459);2bin_A(0.035) Hotspot-linked S:1|W:2|K:1 0.035 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 372 4loe_B(0.0459);2bin_A(0.035) Hotspot C:4|G:7|H:143 0.035 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 372 4loe_B(0.0459);2bin_A(0.035) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.035 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 372 4loe_B(0.0459);2bin_A(0.035) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.035 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 L194 194 372 4loe_B(0.0459);2bin_A(0.035) Hotspot P:2|R:15|F:3|H:3 0.035 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 Y236 236 372 4loe_B(0.0459);2bin_A(0.035) Hotspot C:16|D:2|N:2 0.035 20 11 brca:1|paad:1|coadread:1|prad:1|stad:1|hnsc:6|ov:2|lusc:1|lgg:3|luad:2|cscc:1 ENST00000269305 4 3d TP53 M237 237 372 4loe_B(0.0459);2bin_A(0.035) Hotspot V:3|I:17|K:4 0.035 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 372 4loe_B(0.0459);2bin_A(0.035) Hotspot R:3|S:3|F:12|G:1|Y:15 0.035 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 372 4loe_B(0.0459);2bin_A(0.035) Hotspot-linked R:1|G:2 0.035 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 372 4loe_B(0.0459);2bin_A(0.035) Hotspot S:5|F:13|G:1|W:1|Y:3 0.035 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G245 245 372 4loe_B(0.0459);2bin_A(0.035) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.035 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 372 4loe_B(0.0459);2bin_A(0.035) Hotspot-linked R:2|V:3|I:5 0.035 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 V274 274 372 4loe_B(0.0459);2bin_A(0.035) Hotspot A:4|D:5|F:7|G:4|L:1 0.035 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d BRAF G466 466 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot A:1|E:6|V:10 0.0352 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot-linked L:2 0.0352 2 1 skcm:2 ENST00000288602 6 3d BRAF L514 514 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot-linked P:1 0.0352 1 1 luad:1 ENST00000288602 6 3d BRAF H574 574 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot-linked Q:1|N:1 0.0352 2 1 luad:2 ENST00000288602 6 3d BRAF N581 581 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot S:7|T:2|H:1|I:1 0.0352 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot G:6|H:1|N:5 0.0352 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot-linked L:1 0.0352 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 374 3d4q_A(0.0428);3psd_B(0.0414);4wo5_A(0.0357);3psd_A(0.0365);3psb_B(0.036);3psb_A(0.036);4e26_B(0.0397);3ppj_A(0.0393);4ehg_A(0.0352) Hotspot R:2|S:1|D:1|V:1 0.0352 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d VCL F212 212 375 3rf3_A(0.0669);3rf3_B(0.0649);3tj6_A(0.0352);2ibf_A(0.0407);2hsq_A(0.0382);1ydi_A(0.036);2gdc_A(0.0365);1rke_A(0.0404);3zdl_A(0.0364);1xwj_A(0.0368);1zw3_A(0.0373);3s90_A(0.0422) Cluster-exclusive C:1 0.0352 1 1 lgg:1 ENST00000211998 4 3d VCL A226 226 375 3rf3_A(0.0669);3rf3_B(0.0649);3tj6_A(0.0352);2ibf_A(0.0407);2hsq_A(0.0382);1ydi_A(0.036);2gdc_A(0.0365);1rke_A(0.0404);3zdl_A(0.0364);1xwj_A(0.0368);1zw3_A(0.0373);3s90_A(0.0422) Cluster-exclusive T:1 0.0352 1 1 coadread:1 ENST00000211998 4 3d VCL R230 230 375 3rf3_A(0.0669);3rf3_B(0.0649);3tj6_A(0.0352);2ibf_A(0.0407);2hsq_A(0.0382);1ydi_A(0.036);2gdc_A(0.0365);1rke_A(0.0404);3zdl_A(0.0364);1xwj_A(0.0368);1zw3_A(0.0373);3s90_A(0.0422) Cluster-exclusive C:1|H:1 0.0352 2 2 coadread:1|skcm:1 ENST00000211998 4 3d ITGA1 R304 304 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive Q:1 0.0358 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive F:1 0.0358 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive S:1 0.0358 1 1 mcl:1 ENST00000282588 6 3d ITGA1 E333 333 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive G:1|K:1 0.0358 2 2 skcm:1|lihc:1 ENST00000282588 6 3d ITGA1 H338 338 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive P:1 0.0358 1 1 paad:1 ENST00000282588 6 3d ITGA1 F339 339 378 1qc5_B(0.0454);2b2x_A(0.0388);1qc5_A(0.0382);1mhp_A(0.0367);1mhp_B(0.0423);1pt6_B(0.0516);4a0q_A(0.0368);4a0q_B(0.0358);1ck4_A(0.0502);1qcy_A(0.036);1pt6_A(0.0405);1ck4_B(0.0399) Cluster-exclusive L:1 0.0358 1 1 coadread:1 ENST00000282588 6 3d ZNF443 C314 314 382 1n8e_B(0.0362) Cluster-exclusive Y:1 0.0362 1 1 brca:1 ENST00000301547 5 3d ZNF443 G315 315 382 1n8e_B(0.0362) Cluster-exclusive W:1 0.0362 1 1 luad:1 ENST00000301547 5 3d ZNF443 S319 319 382 1n8e_B(0.0362) Cluster-exclusive R:1 0.0362 1 1 ucs:1 ENST00000301547 5 3d TXNL4A P36 36 384 4cdo_C(0.0438);4cdo_A(0.0416);4bwq_A(0.0376);4bws_A(0.0401);4bwq_C(0.0441);4bwq_E(0.0441);1qgv_A(0.0363);4bws_D(0.0458);4bwq_G(0.0424);1syx_A(0.0381);1syx_E(0.0426);1syx_C(0.0413) Cluster-exclusive H:1 0.0363 1 1 lihc:1 ENST00000269601 5 3d TXNL4A K40 40 384 4cdo_C(0.0438);4cdo_A(0.0416);4bwq_A(0.0376);4bws_A(0.0401);4bwq_C(0.0441);4bwq_E(0.0441);1qgv_A(0.0363);4bws_D(0.0458);4bwq_G(0.0424);1syx_A(0.0381);1syx_E(0.0426);1syx_C(0.0413) Cluster-exclusive N:1 0.0363 1 1 lgg:1 ENST00000269601 5 3d TXNL4A E43 43 384 4cdo_C(0.0438);4cdo_A(0.0416);4bwq_A(0.0376);4bws_A(0.0401);4bwq_C(0.0441);4bwq_E(0.0441);1qgv_A(0.0363);4bws_D(0.0458);4bwq_G(0.0424);1syx_A(0.0381);1syx_E(0.0426);1syx_C(0.0413) Cluster-exclusive Q:1 0.0363 1 1 cesc:1 ENST00000269601 5 3d TXNL4A V44 44 384 4cdo_C(0.0438);4cdo_A(0.0416);4bwq_A(0.0376);4bws_A(0.0401);4bwq_C(0.0441);4bwq_E(0.0441);1qgv_A(0.0363);4bws_D(0.0458);4bwq_G(0.0424);1syx_A(0.0381);1syx_E(0.0426);1syx_C(0.0413) Cluster-exclusive I:1 0.0363 1 1 skcm:1 ENST00000269601 5 3d TXNL4A A105 105 384 4cdo_C(0.0438);4cdo_A(0.0416);4bwq_A(0.0376);4bws_A(0.0401);4bwq_C(0.0441);4bwq_E(0.0441);1qgv_A(0.0363);4bws_D(0.0458);4bwq_G(0.0424);1syx_A(0.0381);1syx_E(0.0426);1syx_C(0.0413) Cluster-exclusive V:1 0.0363 1 1 skcm:1 ENST00000269601 5 3d BRAF G464 464 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot-linked V:2 0.0366 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot A:1|E:6|V:10 0.0366 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot-linked L:2 0.0366 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot A:9|R:3|S:1|E:2|V:6 0.0366 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot-linked I:1 0.0366 1 1 paad:1 ENST00000288602 6 3d BRAF D594 594 388 3psb_B(0.0382);3psb_A(0.0385);4ehg_A(0.0366);3d4q_B(0.044);2fb8_B(0.0438);3pri_A(0.0413);3pri_B(0.0451);3d4q_A(0.0455);2fb8_A(0.0398);3prf_B(0.0409);4h58_B(0.0436);3prf_A(0.0421);3psd_B(0.0443);3psd_A(0.039);4h58_A(0.0431);4wo5_A(0.0375);4e26_B(0.0399);4mnf_B(0.0438);4mnf_A(0.0427);3ppj_A(0.0388);3ppk_B(0.0417);3ppk_A(0.0428);3ppj_B(0.039) Hotspot G:6|H:1|N:5 0.0366 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d SMAD4 P91 91 391 3qsv_A(0.0368) Cluster-exclusive S:1 0.0368 1 1 skcm:1 ENST00000342988 3 3d SMAD4 H92 92 391 3qsv_A(0.0368) Cluster-exclusive Y:1 0.0368 1 1 cesc:1 ENST00000342988 3 3d SMAD4 Y95 95 391 3qsv_A(0.0368) Cluster-exclusive C:1 0.0368 1 1 luad:1 ENST00000342988 3 3d SMAD4 A96 96 391 3qsv_A(0.0368) Cluster-exclusive D:1 0.0368 1 1 paad:1 ENST00000342988 3 3d SMAD4 R97 97 391 3qsv_A(0.0368) Cluster-exclusive C:1|H:2 0.0368 3 3 coadread:1|hnsc:1|ucec:1 ENST00000342988 3 3d SMAD4 W99 99 391 3qsv_A(0.0368) Cluster-exclusive C:1 0.0368 1 1 hnsc:1 ENST00000342988 3 3d SMAD4 R100 100 391 3qsv_A(0.0368) Cluster-exclusive W:1 0.0368 1 1 luad:1 ENST00000342988 3 3d SMAD4 P130 130 391 3qsv_A(0.0368) Cluster-exclusive L:1 0.0368 1 1 paad:1 ENST00000342988 3 3d HDAC8 M40 40 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive V:1 0.0369 1 1 luad:1 ENST00000373573 3 3d HDAC8 L44 44 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive F:1 0.0369 1 1 luad:1 ENST00000373573 3 3d HDAC8 A49 49 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive V:1 0.0369 1 1 ov:1 ENST00000373573 3 3d HDAC8 R313 313 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive G:1 0.0369 1 1 kirp:1 ENST00000373573 3 3d HDAC8 P332 332 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive Q:1 0.0369 1 1 skcm:1 ENST00000373573 3 3d HDAC8 H334 334 392 3rqd_B(0.0369);1t64_B(0.039);1vkg_A(0.0976) Cluster-exclusive Y:1 0.0369 1 1 thca:1 ENST00000373573 3 3d GNAI3 Y74 74 398 4g5r_D(0.0375) Cluster-exclusive C:1 0.0375 1 1 stad:1 ENST00000369851 4 3d GNAI3 M119 119 398 4g5r_D(0.0375) Cluster-exclusive T:1 0.0375 1 1 brca:1 ENST00000369851 4 3d GNAI3 S163 163 398 4g5r_D(0.0375) Cluster-exclusive A:1|F:1 0.0375 2 2 skcm:1|kirp:1 ENST00000369851 4 3d GNAI3 Q164 164 398 4g5r_D(0.0375) Cluster-exclusive P:1|H:1 0.0375 2 2 ov:1|ucec:1 ENST00000369851 4 3d CALM1 I64 64 399 1j7o_A(0.0376) Cluster-exclusive T:1 0.0376 1 1 lihc:1 ENST00000272298 7 3d CALM1 D65 65 399 1j7o_A(0.0376) Cluster-exclusive E:1 0.0376 1 1 lihc:1 ENST00000272298 7 3d CALM1 P67 67 399 1j7o_A(0.0376) Cluster-exclusive L:1 0.0376 1 1 skcm:1 ENST00000272298 7 3d CALM1 L70 70 399 1j7o_A(0.0376) Cluster-exclusive F:2 0.0376 2 2 esca:1|luad:1 ENST00000272298 7 3d CALM1 M73 73 399 1j7o_A(0.0376) Cluster-exclusive I:1 0.0376 1 1 luad:1 ENST00000272298 7 3d TP53 C238 238 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot R:3|S:3|F:12|G:1|Y:15 0.038 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot S:8|D:6|T:1 0.038 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot-linked R:1|G:2 0.038 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot P:3|A:2|C:6|F:19|Y:9 0.038 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot S:5|F:13|G:1|W:1|Y:3 0.038 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot-linked R:2|V:3|I:5 0.038 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot-linked I:4 0.038 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot P:5|Q:108|W:89|G:2|L:10 0.038 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 V272 272 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot E:1|G:4|K:1|L:1|M:17 0.038 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot P:4|C:119|S:5|H:103|L:22 0.038 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot A:4|D:5|F:7|G:4|L:1 0.038 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 401 3igk_A(0.038);3d0a_D(0.045);3d0a_C(0.041);3d0a_B(0.0418) Hotspot R:1|S:4|F:10|Y:15 0.038 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d FBXW7 R465 465 402 2ovr_B(0.0388);2ovq_B(0.038);2ovp_B(0.0495) Hotspot P:1|C:33|G:1|H:26|L:1 0.038 62 14 acc:1|brca:2|coadread:23|cll:1|esca:1|ucs:7|hnsc:2|ov:1|lusc:1|stad:10|mbl:1|ucec:7|cesc:4|luad:1 ENST00000281708 4 3d FBXW7 R505 505 402 2ovr_B(0.0388);2ovq_B(0.038);2ovp_B(0.0495) Hotspot C:16|S:1|G:19|H:2|L:2 0.038 40 12 coadread:8|cll:1|stad:1|esca:1|ucs:3|blca:4|hnsc:7|ov:1|skcm:2|ucec:6|lusc:3|cesc:3 ENST00000281708 4 3d ITGA4 L427 427 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive V:1 0.0381 1 1 skcm:1 ENST00000397033 2 3d ITGA4 S428 428 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive T:1 0.0381 1 1 luad:1 ENST00000397033 2 3d ITGA4 A452 452 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive V:1 0.0381 1 1 coadread:1 ENST00000397033 2 3d ITGA4 R454 454 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive W:2|L:1 0.0381 3 2 skcm:2|kirp:1 ENST00000397033 2 3d ITGA4 S455 455 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive Y:1 0.0381 1 1 cesc:1 ENST00000397033 2 3d ITGA4 S457 457 403 3v4v_C(0.0424);3v4v_A(0.0426);3v4p_C(0.0391);3v4p_A(0.0381) Cluster-exclusive P:1|F:1 0.0381 2 2 ucec:1|cesc:1 ENST00000397033 2 3d SNAP29 S78 78 407 4wy4_C(0.0385) Cluster-exclusive F:1 0.0385 1 1 skcm:1 ENST00000215730 7 3d SNAP29 E79 79 407 4wy4_C(0.0385) Cluster-exclusive K:1 0.0385 1 1 blca:1 ENST00000215730 7 3d SNAP29 A82 82 407 4wy4_C(0.0385) Cluster-exclusive T:1 0.0385 1 1 paad:1 ENST00000215730 7 3d SNAP29 R83 83 407 4wy4_C(0.0385) Cluster-exclusive C:1 0.0385 1 1 skcm:1 ENST00000215730 7 3d SNAP29 E79 79 408 4wy4_C(0.0385) Cluster-exclusive K:1 0.0385 1 1 blca:1 ENST00000215730 7 3d SNAP29 A82 82 408 4wy4_C(0.0385) Cluster-exclusive T:1 0.0385 1 1 paad:1 ENST00000215730 7 3d SNAP29 R83 83 408 4wy4_C(0.0385) Cluster-exclusive C:1 0.0385 1 1 skcm:1 ENST00000215730 7 3d SNAP29 G86 86 408 4wy4_C(0.0385) Cluster-exclusive A:1 0.0385 1 1 blca:1 ENST00000215730 7 3d APLP1 R605 605 410 2v5p_A(0.0387) Cluster-exclusive S:1 0.0387 1 1 blca:1 ENST00000221891 4 3d APLP1 R606 606 410 2v5p_A(0.0387) Cluster-exclusive K:1 0.0387 1 1 cscc:1 ENST00000221891 4 3d APLP1 K607 607 410 2v5p_A(0.0387) Cluster-exclusive T:1 0.0387 1 1 skcm:1 ENST00000221891 4 3d APLP1 R632 632 410 2v5p_A(0.0387) Cluster-exclusive H:2 0.0387 2 2 stad:1|ucec:1 ENST00000221891 4 3d APLP1 E633 633 410 2v5p_A(0.0387) Cluster-exclusive K:2 0.0387 2 2 skcm:1|cscc:1 ENST00000221891 4 3d C2 E267 267 411 2i6q_A(0.0451);2i6s_A(0.0553);2odp_A(0.0387) Cluster-exclusive K:1 0.0387 1 1 skcm:1 ENST00000299367 5 3d C2 L271 271 411 2i6q_A(0.0451);2i6s_A(0.0553);2odp_A(0.0387) Cluster-exclusive V:1 0.0387 1 1 cesc:1 ENST00000299367 5 3d C2 K274 274 411 2i6q_A(0.0451);2i6s_A(0.0553);2odp_A(0.0387) Cluster-exclusive E:1 0.0387 1 1 lusc:1 ENST00000299367 5 3d C2 E275 275 411 2i6q_A(0.0451);2i6s_A(0.0553);2odp_A(0.0387) Cluster-exclusive K:1 0.0387 1 1 skcm:1 ENST00000299367 5 3d KEAP1 R459 459 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive Q:1 0.0393 1 1 skcm:1 ENST00000171111 5 3d KEAP1 R460 460 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive G:1 0.0393 1 1 luad:1 ENST00000171111 5 3d KEAP1 I461 461 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive V:1 0.0393 1 1 luad:1 ENST00000171111 5 3d KEAP1 G477 477 414 2o4u_X(0.0393);3ohs_X(0.042);2poq_X(0.0417);2o48_X(0.0465) Cluster-exclusive S:1 0.0393 1 1 thca:1 ENST00000171111 5 3d EGFR R831 831 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot-linked H:2 0.0395 2 2 coadread:1|luad:1 ENST00000275493 2 3d EGFR R832 832 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot-linked C:1|H:1 0.0395 2 2 ucec:1|kirc:1 ENST00000275493 2 3d EGFR L833 833 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot-linked F:1|V:1 0.0395 2 1 luad:2 ENST00000275493 2 3d EGFR L858 858 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot R:30 0.0395 30 1 luad:30 ENST00000275493 2 3d EGFR L861 861 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot Q:7 0.0395 7 2 lusc:2|luad:5 ENST00000275493 2 3d EGFR H893 893 415 2jit_B(0.0395);3ika_B(0.0402) Hotspot-linked Y:1 0.0395 1 1 coadread:1 ENST00000275493 2 3d ITGA1 Q303 303 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive E:1 0.0399 1 1 prad:1 ENST00000282588 6 3d ITGA1 R304 304 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive Q:1 0.0399 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive F:1 0.0399 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive S:1 0.0399 1 1 mcl:1 ENST00000282588 6 3d ITGA1 E333 333 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive G:1|K:1 0.0399 2 2 skcm:1|lihc:1 ENST00000282588 6 3d ITGA1 H338 338 419 1ck4_A(0.0502);1ck4_B(0.0399) Cluster-exclusive P:1 0.0399 1 1 paad:1 ENST00000282588 6 3d SLIT2 A455 455 425 2zmv_A(0.0404) Cluster-exclusive D:1|V:1 0.0404 2 2 coadread:1|hnsc:1 ENST00000504154 1 3d SLIT2 R456 456 425 2zmv_A(0.0404) Cluster-exclusive C:1|H:1 0.0404 2 2 stad:1|mcl:1 ENST00000504154 1 3d CENPE R128 128 427 1t5c_A(0.0408) Cluster-exclusive C:1 0.0408 1 1 stad:1 ENST00000265148 3 3d CENPE V129 129 427 1t5c_A(0.0408) Cluster-exclusive A:1|L:1 0.0408 2 2 lihc:1|luad:1 ENST00000265148 3 3d CENPE S130 130 427 1t5c_A(0.0408) Cluster-exclusive F:1 0.0408 1 1 skcm:1 ENST00000265148 3 3d CENPE E170 170 427 1t5c_A(0.0408) Cluster-exclusive K:2 0.0408 2 2 brca:1|coadread:1 ENST00000265148 3 3d TP53 G244 244 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot R:1|C:8|S:5|D:9|V:2 0.0411 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0411 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot-linked R:2|V:3|I:5 0.0411 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot-linked I:4 0.0411 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0411 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0411 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 P250 250 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot-linked L:12 0.0411 12 9 paad:1|coadread:1|kich:1|stad:1|ov:2|gbc:1|lusc:1|lgg:2|luad:2 ENST00000269305 4 3d TP53 R273 273 429 2h1l_Q(0.0457);2h1l_P(0.0459);2h1l_O(0.0458);2h1l_N(0.0431);2h1l_U(0.0491);2h1l_T(0.0446);2h1l_S(0.0493);2h1l_R(0.0454);2h1l_X(0.0415);2h1l_W(0.0411);2h1l_V(0.0492);2h1l_M(0.0451) Hotspot P:4|C:119|S:5|H:103|L:22 0.0411 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d SMAD4 D351 351 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot A:1|G:3|H:2|Y:2 0.0411 8 6 paad:2|coadread:2|prad:1|stad:1|esca:1|luad:1 ENST00000342988 3 3d SMAD4 G352 352 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked A:1|R:1 0.0411 2 2 coadread:1|stad:1 ENST00000342988 3 3d SMAD4 Y353 353 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked N:1 0.0411 1 1 prad:1 ENST00000342988 3 3d SMAD4 R361 361 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot P:1|C:18|G:2|H:20 0.0411 41 8 brca:1|paad:8|coadread:20|stad:5|esca:3|hnsc:1|cesc:2|luad:1 ENST00000342988 3 3d SMAD4 C363 363 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked Y:1 0.0411 1 1 stad:1 ENST00000342988 3 3d SMAD4 G365 365 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked R:1|D:1 0.0411 2 1 coadread:2 ENST00000342988 3 3d SMAD4 G384 384 430 1dd1_C(0.0567);1g88_C(0.0664);1g88_B(0.0484);1dd1_B(0.0411) Hotspot-linked D:1 0.0411 1 1 paad:1 ENST00000342988 3 3d SNRPN C43 43 432 3pgw_B(0.0413) Cluster-exclusive R:1 0.0413 1 1 stad:1 ENST00000346403 6 3d SNRPN D44 44 432 3pgw_B(0.0413) Cluster-exclusive V:1 0.0413 1 1 skcm:1 ENST00000346403 6 3d SNRPN G68 68 432 3pgw_B(0.0413) Cluster-exclusive C:1 0.0413 1 1 luad:1 ENST00000346403 6 3d PCDHB13 H512 512 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive N:1 0.0416 1 1 brca:1 ENST00000341948 4 3d PCDHB13 A515 515 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive G:1 0.0416 1 1 lihc:1 ENST00000341948 4 3d PCDHB13 L519 519 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive Q:1 0.0416 1 1 luad:1 ENST00000341948 4 3d PCDHB13 R530 530 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive C:1|H:3|L:1 0.0416 5 5 acc:1|coadread:1|esca:1|ov:1|luad:1 ENST00000341948 4 3d PCDHB13 S534 534 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive T:1 0.0416 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 D535 535 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive E:1 0.0416 1 1 coadread:1 ENST00000341948 4 3d PCDHB13 G537 537 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive V:1 0.0416 1 1 paad:1 ENST00000341948 4 3d PCDHB13 S538 538 435 4bba_A(0.0694);4bb9_A(0.0704);4lc9_A(0.0416) Cluster-exclusive F:1 0.0416 1 1 skcm:1 ENST00000341948 4 3d GRB2 F95 95 437 1qg1_E(0.0419) Cluster-exclusive V:1 0.0419 1 1 brca:1 ENST00000316804 5 3d GRB2 R112 112 437 1qg1_E(0.0419) Cluster-exclusive Q:1 0.0419 1 1 skcm:1 ENST00000316804 5 3d GRB2 D113 113 437 1qg1_E(0.0419) Cluster-exclusive H:1 0.0419 1 1 all:1 ENST00000316804 5 3d GRB2 G116 116 437 1qg1_E(0.0419) Cluster-exclusive R:1|W:1 0.0419 2 2 coadread:1|lihc:1 ENST00000316804 5 3d GRB2 K117 117 437 1qg1_E(0.0419) Cluster-exclusive R:1 0.0419 1 1 ucec:1 ENST00000316804 5 3d GRB2 Y118 118 437 1qg1_E(0.0419) Cluster-exclusive S:1 0.0419 1 1 mmyl:1 ENST00000316804 5 3d GRB2 S127 127 437 1qg1_E(0.0419) Cluster-exclusive Y:1 0.0419 1 1 coadread:1 ENST00000316804 5 3d MAP2K1 F53 53 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot V:1|I:1|L:4 0.0422 6 4 coadread:3|stad:1|skcm:1|luad:1 ENST00000307102 5 3d MAP2K1 Q56 56 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot-linked P:1 0.0422 1 1 luad:1 ENST00000307102 5 3d MAP2K1 K57 57 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot T:3|N:7 0.0422 10 6 prad:1|stad:1|dlbc:1|hnsc:1|skcm:2|luad:4 ENST00000307102 5 3d MAP2K1 G128 128 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot-linked D:2|V:1 0.0422 3 2 coadread:2|luad:1 ENST00000307102 5 3d MAP2K1 Y130 130 438 3eqh_A(0.0486);3zm4_A(0.0422);3w8q_A(0.0449);3zls_A(0.0467);3eqg_A(0.0482);3eqf_A(0.0472);3zlx_A(0.0455);3zly_A(0.045);3eqd_A(0.0484);3eqc_A(0.048) Hotspot-linked C:2 0.0422 2 2 dlbc:1|lihc:1 ENST00000307102 5 3d DNAJC6 P242 242 442 3n0a_A(0.0428) Cluster-exclusive S:1 0.0428 1 1 cscc:1 ENST00000395325 3 3d DNAJC6 G250 250 442 3n0a_A(0.0428) Cluster-exclusive E:1 0.0428 1 1 ucec:1 ENST00000395325 3 3d DNAJC6 C251 251 442 3n0a_A(0.0428) Cluster-exclusive F:1 0.0428 1 1 luad:1 ENST00000395325 3 3d DNAJC6 R252 252 442 3n0a_A(0.0428) Cluster-exclusive C:2|S:1|H:2 0.0428 5 4 coadread:1|stad:2|lusc:1|cscc:1 ENST00000395325 3 3d DNAJC6 R278 278 442 3n0a_A(0.0428) Cluster-exclusive H:1 0.0428 1 1 gbm:1 ENST00000395325 3 3d DNAJC6 H302 302 442 3n0a_A(0.0428) Cluster-exclusive Y:1 0.0428 1 1 skcm:1 ENST00000395325 3 3d PTPN11 F71 71 444 4dgp_A(0.0558);4h1o_A(0.0495);4gwf_B(0.0432);4gwf_A(0.0436);2shp_A(0.0697);4dgx_A(0.0566) Hotspot-linked L:3 0.0432 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 444 4dgp_A(0.0558);4h1o_A(0.0495);4gwf_B(0.0432);4gwf_A(0.0436);2shp_A(0.0697);4dgx_A(0.0566) Hotspot T:3|D:2|V:2 0.0432 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 444 4dgp_A(0.0558);4h1o_A(0.0495);4gwf_B(0.0432);4gwf_A(0.0436);2shp_A(0.0697);4dgx_A(0.0566) Hotspot A:2|G:1|K:4 0.0432 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 L262 262 444 4dgp_A(0.0558);4h1o_A(0.0495);4gwf_B(0.0432);4gwf_A(0.0436);2shp_A(0.0697);4dgx_A(0.0566) Hotspot-linked F:1 0.0432 1 1 skcm:1 ENST00000351677 2 3d PTPN11 Q506 506 444 4dgp_A(0.0558);4h1o_A(0.0495);4gwf_B(0.0432);4gwf_A(0.0436);2shp_A(0.0697);4dgx_A(0.0566) Hotspot-linked P:1 0.0432 1 1 skcm:1 ENST00000351677 2 3d ZNF548 A238 238 446 2roc_A(0.0432) Cluster-exclusive T:1|V:1 0.0432 2 2 paad:1|coadread:1 ENST00000366197 5 3d ZNF548 C286 286 446 2roc_A(0.0432) Cluster-exclusive R:1 0.0432 1 1 blca:1 ENST00000366197 5 3d ZNF548 K288 288 446 2roc_A(0.0432) Cluster-exclusive E:1 0.0432 1 1 luad:1 ENST00000366197 5 3d ZNF548 F289 289 446 2roc_A(0.0432) Cluster-exclusive L:1 0.0432 1 1 coadread:1 ENST00000366197 5 3d ZNF548 R291 291 446 2roc_A(0.0432) Cluster-exclusive W:1|L:1 0.0432 2 2 lihc:1|cscc:1 ENST00000366197 5 3d AMY1A I327 327 449 1b2y_A(0.0528);2cpu_A(0.0529);3ole_A(0.0517);1kb3_A(0.0526);3old_A(0.0529);1xv8_A(0.0593);4gqq_A(0.0549);1kbk_A(0.0546);4gqr_A(0.0596);1u2y_A(0.0537);3olg_A(0.0573);3oli_A(0.0574);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);1xd0_A(0.0557);3bay_A(0.0507);3ij9_A(0.0561);1xh0_A(0.0538);3ij8_A(0.0606);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);1u33_A(0.0566);1mfu_A(0.061);3bai_A(0.0567);3bak_A(0.0537);2qmk_A(0.0538);3baj_A(0.0537);1u30_A(0.0553);1jxk_A(0.0584);1c8q_A(0.0576);1jxj_A(0.0606);1hny_A(0.0568);3blp_X(0.0596);1kbb_A(0.0505);1xgz_A(0.0535);3cpu_A(0.0545);1xcx_A(0.0541);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive V:1 0.0432 1 1 luad:1 ENST00000330330 5 3d AMY1A D332 332 449 1b2y_A(0.0528);2cpu_A(0.0529);3ole_A(0.0517);1kb3_A(0.0526);3old_A(0.0529);1xv8_A(0.0593);4gqq_A(0.0549);1kbk_A(0.0546);4gqr_A(0.0596);1u2y_A(0.0537);3olg_A(0.0573);3oli_A(0.0574);1xd1_A(0.055);1bsi_A(0.0529);3bax_A(0.054);1xd0_A(0.0557);3bay_A(0.0507);3ij9_A(0.0561);1xh0_A(0.0538);3ij8_A(0.0606);1xh1_A(0.0555);3ij7_A(0.056);1xh2_A(0.0506);1cpu_A(0.0541);1q4n_X(0.0609);3baw_A(0.0569);1smd_A(0.0574);1u33_A(0.0566);1mfu_A(0.061);3bai_A(0.0567);3bak_A(0.0537);2qmk_A(0.0538);3baj_A(0.0537);1u30_A(0.0553);1jxk_A(0.0584);1c8q_A(0.0576);1jxj_A(0.0606);1hny_A(0.0568);3blp_X(0.0596);1kbb_A(0.0505);1xgz_A(0.0535);3cpu_A(0.0545);1xcx_A(0.0541);1xcw_A(0.0549);1kgu_A(0.0556);1kgx_A(0.0561);1kgw_A(0.0432);2qv4_A(0.0539) Cluster-exclusive E:1 0.0432 1 1 luad:1 ENST00000330330 5 3d BRAF G466 466 450 4ehe_A(0.0433) Hotspot A:1|E:6|V:10 0.0433 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 450 4ehe_A(0.0433) Hotspot-linked L:2 0.0433 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 450 4ehe_A(0.0433) Hotspot A:9|R:3|S:1|E:2|V:6 0.0433 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF K601 601 450 4ehe_A(0.0433) Hotspot T:1|E:12|N:2 0.0433 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PPP2R1A S219 219 460 2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);3dw8_D(0.055);4i5l_D(0.054);4i5n_A(0.0465);1b3u_B(0.045);4i5n_D(0.0483);1b3u_A(0.0496);2ie3_A(0.0524);4i5l_A(0.053);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Hotspot-linked L:3 0.045 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A S256 256 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive F:4|Y:2 0.045 6 2 ucs:2|ucec:4 ENST00000322088 6 3d PPP2R1A W257 257 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive C:1 0.045 1 1 ov:1 ENST00000322088 6 3d PPP2R1A R258 258 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Hotspot-linked C:1|H:3 0.045 4 3 coadread:1|ucec:2|luad:1 ENST00000322088 6 3d PPP2R1A R260 260 461 3dw8_D(0.055);2nyl_A(0.0547);3dw8_A(0.052);2nym_A(0.0504);2nym_D(0.0494);4i5l_D(0.054);2nyl_D(0.0532);4i5n_A(0.0465);4i5n_D(0.0483);4i5l_A(0.053);2npp_D(0.0564);2iae_A(0.048);2ie4_A(0.0544);2pf4_B(0.0504);2pf4_A(0.0511);2npp_A(0.052);1b3u_B(0.045);1b3u_A(0.0496);2ie3_A(0.0524);2pkg_A(0.0551);2pkg_B(0.0505);3fga_A(0.0503);2pf4_C(0.0485);3k7v_A(0.0477);3k7w_A(0.0482) Cluster-exclusive C:1|G:1 0.045 2 2 ov:1|lihc:1 ENST00000322088 6 3d ANKLE2 W495 495 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive C:1 0.0453 1 1 luad:1 ENST00000357997 5 3d ANKLE2 E533 533 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive K:1 0.0453 1 1 lusc:1 ENST00000357997 5 3d ANKLE2 D534 534 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive N:1 0.0453 1 1 brca:1 ENST00000357997 5 3d ANKLE2 R536 536 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive C:2|H:1 0.0453 3 2 coadread:2|ucec:1 ENST00000357997 5 3d ANKLE2 Q614 614 465 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive E:1 0.0453 1 1 luad:1 ENST00000357997 5 3d ANKLE2 D534 534 466 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive N:1 0.0453 1 1 brca:1 ENST00000357997 5 3d ANKLE2 R536 536 466 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive C:2|H:1 0.0453 3 2 coadread:2|ucec:1 ENST00000357997 5 3d ANKLE2 K537 537 466 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive R:1|T:1|N:1 0.0453 3 3 brca:1|stad:1|lihc:1 ENST00000357997 5 3d ANKLE2 Q614 614 466 3bxw_A(0.0492);3bxw_B(0.0453) Cluster-exclusive E:1 0.0453 1 1 luad:1 ENST00000357997 5 3d ITGA4 G53 53 471 4irz_A(0.0462) Cluster-exclusive V:1 0.0462 1 1 stad:1 ENST00000397033 2 3d ITGA4 S426 426 471 4irz_A(0.0462) Cluster-exclusive L:5 0.0462 5 2 coadread:1|skcm:4 ENST00000397033 2 3d ITGA4 L427 427 471 4irz_A(0.0462) Cluster-exclusive V:1 0.0462 1 1 skcm:1 ENST00000397033 2 3d ITGA4 S428 428 471 4irz_A(0.0462) Cluster-exclusive T:1 0.0462 1 1 luad:1 ENST00000397033 2 3d ITGA4 G451 451 471 4irz_A(0.0462) Cluster-exclusive R:1 0.0462 1 1 blca:1 ENST00000397033 2 3d ITGA4 A452 452 471 4irz_A(0.0462) Cluster-exclusive V:1 0.0462 1 1 coadread:1 ENST00000397033 2 3d ITGA4 S455 455 471 4irz_A(0.0462) Cluster-exclusive Y:1 0.0462 1 1 cesc:1 ENST00000397033 2 3d ITGA4 S457 457 471 4irz_A(0.0462) Cluster-exclusive P:1|F:1 0.0462 2 2 ucec:1|cesc:1 ENST00000397033 2 3d ITGA4 A458 458 471 4irz_A(0.0462) Cluster-exclusive P:1 0.0462 1 1 luad:1 ENST00000397033 2 3d ITGA4 V459 459 471 4irz_A(0.0462) Cluster-exclusive D:1 0.0462 1 1 brca:1 ENST00000397033 2 3d PTPN11 A72 72 472 4h34_A(0.0463) Hotspot T:3|D:2|V:2 0.0463 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 472 4h34_A(0.0463) Hotspot A:2|G:1|K:4 0.0463 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d PTPN11 S502 502 472 4h34_A(0.0463) Hotspot-linked P:1|L:1 0.0463 2 2 gbm:1|laml:1 ENST00000351677 2 3d PTPN11 Q506 506 472 4h34_A(0.0463) Hotspot-linked P:1 0.0463 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 472 4h34_A(0.0463) Hotspot-linked K:2 0.0463 2 2 gbm:1|nbl:1 ENST00000351677 2 3d EP300 Y1397 1397 473 4bhw_B(0.0464);4bhw_A(0.0493) Hotspot-linked D:1 0.0464 1 1 ucec:1 ENST00000263253 7 3d EP300 L1398 1398 473 4bhw_B(0.0464);4bhw_A(0.0493) Hotspot-linked P:1 0.0464 1 1 lusc:1 ENST00000263253 7 3d EP300 D1399 1399 473 4bhw_B(0.0464);4bhw_A(0.0493) Hotspot Y:2|N:16 0.0464 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 Y1446 1446 473 4bhw_B(0.0464);4bhw_A(0.0493) Hotspot-linked C:1 0.0464 1 1 hnsc:1 ENST00000263253 7 3d EP300 R1627 1627 473 4bhw_B(0.0464);4bhw_A(0.0493) Hotspot-linked Q:1|W:4 0.0464 5 5 coadread:1|stad:1|blca:1|skcm:1|luad:1 ENST00000263253 7 3d EP300 G1375 1375 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot-linked R:1 0.0464 1 1 lusm:1 ENST00000263253 7 3d EP300 Y1397 1397 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot-linked D:1 0.0464 1 1 ucec:1 ENST00000263253 7 3d EP300 L1398 1398 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot-linked P:1 0.0464 1 1 lusc:1 ENST00000263253 7 3d EP300 D1399 1399 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot Y:2|N:16 0.0464 18 6 esca:2|blca:2|hnsc:6|mbl:1|lusc:2|cesc:5 ENST00000263253 7 3d EP300 Y1446 1446 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot-linked C:1 0.0464 1 1 hnsc:1 ENST00000263253 7 3d EP300 H1451 1451 474 4bhw_B(0.0464);3biy_A(0.0641);4bhw_A(0.0493) Hotspot P:1|R:1|L:1 0.0464 3 3 brca:1|blca:1|ucec:1 ENST00000263253 7 3d ITGB1 M149 149 475 4wk0_B(0.0955);3vi3_D(0.0502);3vi3_B(0.0464);4wk2_B(0.0897);4wjk_B(0.0993) Cluster-exclusive V:1|I:1|L:1 0.0464 3 3 brca:1|skcm:1|lusc:1 ENST00000302278 3 3d ITGB1 D158 158 475 4wk0_B(0.0955);3vi3_D(0.0502);3vi3_B(0.0464);4wk2_B(0.0897);4wjk_B(0.0993) Cluster-exclusive N:3 0.0464 3 2 coadread:1|hnsc:2 ENST00000302278 3 3d ITGB1 V162 162 475 4wk0_B(0.0955);3vi3_D(0.0502);3vi3_B(0.0464);4wk2_B(0.0897);4wjk_B(0.0993) Cluster-exclusive G:1 0.0464 1 1 hnsc:1 ENST00000302278 3 3d TP53 S240 240 477 4lof_A(0.0467) Hotspot-linked R:1|G:2 0.0467 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 R248 248 477 4lof_A(0.0467) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0467 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 V272 272 477 4lof_A(0.0467) Hotspot E:1|G:4|K:1|L:1|M:17 0.0467 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 477 4lof_A(0.0467) Hotspot P:4|C:119|S:5|H:103|L:22 0.0467 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 477 4lof_A(0.0467) Hotspot A:4|D:5|F:7|G:4|L:1 0.0467 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 477 4lof_A(0.0467) Hotspot R:1|S:4|F:10|Y:15 0.0467 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d TP53 D281 281 477 4lof_A(0.0467) Hotspot P:1|A:1|E:4|V:4|G:1|H:2|Y:8|N:7 0.0467 28 16 brca:3|mmyl:1|paad:1|cll:1|ucs:1|blca:1|hnsc:1|ov:4|lihc:1|lusc:1|stad:1|gbm:3|nbl:1|ucec:1|kirc:1|luad:6 ENST00000269305 4 3d TUBA3D V181 181 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive M:2 0.0467 2 2 paad:1|luad:1 ENST00000321253 6 3d TUBA3D V182 182 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive M:1 0.0467 1 1 hnsc:1 ENST00000321253 6 3d TUBA3D D396 396 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive N:2 0.0467 2 2 coadread:1|skcm:1 ENST00000321253 6 3d TUBA3D M398 398 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive V:1 0.0467 1 1 stad:1 ENST00000321253 6 3d TUBA3D Y399 399 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive S:1 0.0467 1 1 luad:1 ENST00000321253 6 3d TUBA3D R402 402 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive Q:1 0.0467 1 1 luad:1 ENST00000321253 6 3d TUBA3D A403 403 478 4hna_A(0.0728);3hkb_C(0.0653);3hke_A(0.0651);4f6r_A(0.0768);4f61_C(0.064);3ut5_A(0.0652);1sa1_C(0.0578);4drx_C(0.0671);3j1t_B(0.0467);4drx_A(0.066);1sa1_A(0.0637);3ut5_C(0.0604);3hkb_A(0.068);3hkc_A(0.0614);4f61_A(0.0699);2xrp_B(0.0648);3ryf_A(0.0652);3ryc_C(0.0674);3ryc_A(0.0657);4eb6_C(0.0489);3ryh_C(0.0666);3ryi_C(0.0727);3ryf_C(0.0671);3ryh_A(0.0622);3ryi_A(0.0715);4atu_B(0.0655);3e22_C(0.0553);4abo_B(0.0681);4atx_B(0.0631);4eb6_A(0.0586) Cluster-exclusive S:1 0.0467 1 1 npc:1 ENST00000321253 6 3d KRAS A11 11 480 3kkm_A(0.0525);1iaq_A(0.0498);3k9l_B(0.0483);3rsl_A(0.0481);3k9l_C(0.0501);2rge_A(0.0489);3lo5_E(0.0471);3k9l_A(0.0481);2rgg_A(0.051);3lo5_A(0.0469);1iaq_C(0.0506);3con_A(0.0542) Hotspot-linked T:1 0.0469 1 1 paad:1 ENST00000311936 3 3d KRAS G12 12 480 3kkm_A(0.0525);1iaq_A(0.0498);3k9l_B(0.0483);3rsl_A(0.0481);3k9l_C(0.0501);2rge_A(0.0489);3lo5_E(0.0471);3k9l_A(0.0481);2rgg_A(0.051);3lo5_A(0.0469);1iaq_C(0.0506);3con_A(0.0542) Hotspot A:43|R:71|C:115|S:23|D:255|V:227|F:1 0.0469 735 21 brca:6|paad:289|mmyl:9|npc:1|coadread:151|esca:3|ucs:7|thca:1|blca:5|laml:3|ov:6|lihc:1|kirp:2|prad:1|stad:14|gbm:2|skcm:2|ucec:36|cesc:7|mds:1|luad:188 ENST00000311936 3 3d KRAS G13 13 480 3kkm_A(0.0525);1iaq_A(0.0498);3k9l_B(0.0483);3rsl_A(0.0481);3k9l_C(0.0501);2rge_A(0.0489);3lo5_E(0.0471);3k9l_A(0.0481);2rgg_A(0.051);3lo5_A(0.0469);1iaq_C(0.0506);3con_A(0.0542) Hotspot A:1|R:1|C:12|D:75|V:2 0.0469 91 10 mmyl:9|paad:2|coadread:38|cll:2|stad:10|laml:1|lihc:1|ucec:9|cesc:2|luad:17 ENST00000311936 3 3d TICAM1 R114 114 482 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_C(0.0495);4c0m_D(0.0471);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive W:1 0.0471 1 1 stad:1 ENST00000248244 5 3d TICAM1 A117 117 482 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_C(0.0495);4c0m_D(0.0471);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive T:1 0.0471 1 1 hnsc:1 ENST00000248244 5 3d TICAM1 Q119 119 482 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_C(0.0495);4c0m_D(0.0471);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive P:1 0.0471 1 1 luad:1 ENST00000248244 5 3d TICAM1 E120 120 482 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_C(0.0495);4c0m_D(0.0471);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive D:1 0.0471 1 1 lihc:1 ENST00000248244 5 3d TICAM1 A121 121 482 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_C(0.0495);4c0m_D(0.0471);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive V:1 0.0471 1 1 stad:1 ENST00000248244 5 3d PLEKHA6 W81 81 487 2yry_A(0.0474) Cluster-exclusive C:1 0.0474 1 1 kirc:1 ENST00000272203 3 3d PLEKHA6 F82 82 487 2yry_A(0.0474) Cluster-exclusive L:3 0.0474 3 3 prad:1|ov:1|skcm:1 ENST00000272203 3 3d PLEKHA6 V83 83 487 2yry_A(0.0474) Cluster-exclusive I:1 0.0474 1 1 hnsc:1 ENST00000272203 3 3d PLEKHA6 F90 90 487 2yry_A(0.0474) Cluster-exclusive L:1 0.0474 1 1 esca:1 ENST00000272203 3 3d PLEKHA6 Y92 92 487 2yry_A(0.0474) Cluster-exclusive C:1 0.0474 1 1 luad:1 ENST00000272203 3 3d H3C13 D124 124 493 1hio_C(0.0481) Cluster-exclusive Y:1 0.0481 1 1 brca:1 ENST00000331491 1 3d H3C13 L127 127 493 1hio_C(0.0481) Cluster-exclusive F:1 0.0481 1 1 coadread:1 ENST00000331491 1 3d THRA R284 284 495 3jzb_A(0.0484);3ilz_A(0.0489);3hzf_A(0.0577);2h77_A(0.053);2h79_A(0.0497) Cluster-exclusive P:1 0.0484 1 1 luad:1 ENST00000264637 4 3d THRA K288 288 495 3jzb_A(0.0484);3ilz_A(0.0489);3hzf_A(0.0577);2h77_A(0.053);2h79_A(0.0497) Cluster-exclusive E:1 0.0484 1 1 ucec:1 ENST00000264637 4 3d THRA V294 294 495 3jzb_A(0.0484);3ilz_A(0.0489);3hzf_A(0.0577);2h77_A(0.053);2h79_A(0.0497) Cluster-exclusive I:2 0.0484 2 1 stad:2 ENST00000264637 4 3d THRA S296 296 495 3jzb_A(0.0484);3ilz_A(0.0489);3hzf_A(0.0577);2h77_A(0.053);2h79_A(0.0497) Cluster-exclusive F:1 0.0484 1 1 skcm:1 ENST00000264637 4 3d THRA A298 298 495 3jzb_A(0.0484);3ilz_A(0.0489);3hzf_A(0.0577);2h77_A(0.053);2h79_A(0.0497) Cluster-exclusive T:1 0.0484 1 1 stad:1 ENST00000264637 4 3d BRAF G464 464 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot-linked V:2 0.0485 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot A:1|E:6|V:10 0.0485 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot-linked L:2 0.0485 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot A:9|R:3|S:1|E:2|V:6 0.0485 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot-linked I:1 0.0485 1 1 paad:1 ENST00000288602 6 3d BRAF F595 595 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot-linked L:1 0.0485 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot R:2|S:1|D:1|V:1 0.0485 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 497 4jvg_A(0.0541);1uwh_A(0.0533);4ksq_A(0.0508);4dbn_B(0.0574);3q96_A(0.0485);3idp_B(0.0589);3idp_A(0.0569);3ii5_B(0.0512);3ii5_A(0.0516);1uwh_B(0.0523);1uwj_B(0.0561) Hotspot Q:2|R:1|S:1 0.0485 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d MAPK1 R135 135 499 4erk_A(0.0578);4iza_C(0.052);4h3p_A(0.0486) Hotspot-linked K:1 0.0486 1 1 cesc:1 ENST00000215832 6 3d MAPK1 P319 319 499 4erk_A(0.0578);4iza_C(0.052);4h3p_A(0.0486) Hotspot-linked S:1 0.0486 1 1 skcm:1 ENST00000215832 6 3d MAPK1 D321 321 499 4erk_A(0.0578);4iza_C(0.052);4h3p_A(0.0486) Hotspot-linked V:1|N:2 0.0486 3 3 hnsc:1|skcm:1|cesc:1 ENST00000215832 6 3d MAPK1 E322 322 499 4erk_A(0.0578);4iza_C(0.052);4h3p_A(0.0486) Hotspot K:15 0.0486 15 3 blca:1|hnsc:7|cesc:7 ENST00000215832 6 3d OXSM A389 389 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive V:1 0.0486 1 1 stad:1 ENST00000280701 3 3d OXSM G391 391 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive W:1 0.0486 1 1 luad:1 ENST00000280701 3 3d OXSM V393 393 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive F:1 0.0486 1 1 lihc:1 ENST00000280701 3 3d OXSM E394 394 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive K:1 0.0486 1 1 blca:1 ENST00000280701 3 3d OXSM T442 442 502 2c9h_A(0.0507);2iwy_A(0.0526);2iwz_B(0.0535);2iwz_A(0.0509);2iwy_B(0.0486) Cluster-exclusive A:1 0.0486 1 1 lihc:1 ENST00000280701 3 3d WDR75 V521 521 503 1bhg_A(0.0527);3hn3_E(0.0486);3hn3_D(0.0542);3hn3_B(0.051);3hn3_A(0.0536) Cluster-exclusive I:1 0.0486 1 1 hnsc:1 ENST00000314761 4 3d ACVR1B A401 401 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive T:1 0.0487 1 1 paad:1 ENST00000257963 4 3d ACVR1B D402 402 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive E:1 0.0487 1 1 paad:1 ENST00000257963 4 3d ACVR1B Y404 404 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive C:1 0.0487 1 1 stad:1 ENST00000257963 4 3d ACVR1B A405 405 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive V:2 0.0487 2 2 ucec:1|lusc:1 ENST00000257963 4 3d ACVR1B G407 407 504 3faa_C(0.0487);3kcf_C(0.0512);1b6c_B(0.0639);1rw8_A(0.0656) Cluster-exclusive R:1 0.0487 1 1 coadread:1 ENST00000257963 4 3d TICAM1 S112 112 505 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive L:1 0.0488 1 1 stad:1 ENST00000248244 5 3d TICAM1 R114 114 505 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive W:1 0.0488 1 1 stad:1 ENST00000248244 5 3d TICAM1 A117 117 505 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive T:1 0.0488 1 1 hnsc:1 ENST00000248244 5 3d TICAM1 Q119 119 505 4bsx_C(0.0903);4bsx_B(0.0879);4bsx_A(0.0864);4c0m_A(0.0488);4c0m_B(0.0519);4bsx_D(0.0845) Cluster-exclusive P:1 0.0488 1 1 luad:1 ENST00000248244 5 3d BRAF G466 466 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot A:1|E:6|V:10 0.049 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot-linked L:2 0.049 2 1 skcm:2 ENST00000288602 6 3d BRAF H574 574 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot-linked Q:1|N:1 0.049 2 1 luad:2 ENST00000288602 6 3d BRAF N581 581 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot S:7|T:2|H:1|I:1 0.049 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot G:6|H:1|N:5 0.049 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot-linked L:1 0.049 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 507 3pri_A(0.049);3pri_B(0.0534);3prf_B(0.0497);4h58_B(0.0508) Hotspot R:2|S:1|D:1|V:1 0.049 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d TUBA3D M398 398 510 4ffb_A(0.0494) Cluster-exclusive V:1 0.0494 1 1 stad:1 ENST00000321253 6 3d TUBA3D Y399 399 510 4ffb_A(0.0494) Cluster-exclusive S:1 0.0494 1 1 luad:1 ENST00000321253 6 3d TUBA3D R402 402 510 4ffb_A(0.0494) Cluster-exclusive Q:1 0.0494 1 1 luad:1 ENST00000321253 6 3d TUBA3D A403 403 510 4ffb_A(0.0494) Cluster-exclusive S:1 0.0494 1 1 npc:1 ENST00000321253 6 3d PIK3R1 Y452 452 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Cluster-exclusive C:2|H:1|N:1 0.0497 4 3 esca:1|hnsc:1|ucec:2 ENST00000274335 5 3d PIK3R1 Q572 572 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Hotspot-linked R:1 0.0497 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Hotspot-linked P:3 0.0497 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Hotspot-linked T:1|I:2 0.0497 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d PIK3R1 T576 576 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Cluster-exclusive M:1 0.0497 1 1 esca:1 ENST00000274335 5 3d PIK3R1 R577 577 512 4ovu_B(0.0764);4l2y_B(0.0707);4l23_B(0.0687);4l1b_B(0.0695);4waf_B(0.0497) Cluster-exclusive G:1 0.0497 1 1 lihc:1 ENST00000274335 5 3d RORC Y369 369 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive C:1 0.05 1 1 luad:1 ENST00000318247 6 3d RORC R374 374 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive C:2 0.05 2 2 stad:1|ucec:1 ENST00000318247 6 3d RORC T375 375 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive M:1 0.05 1 1 kirp:1 ENST00000318247 6 3d RORC G383 383 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive D:1 0.05 1 1 stad:1 ENST00000318247 6 3d RORC F401 401 516 4wlb_A(0.0574);4nie_B(0.0735);4qm0_C(0.0592);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);3l0l_A(0.05);4nb6_A(0.0549);4wlb_B(0.0533);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive L:1 0.05 1 1 skcm:1 ENST00000318247 6 3d RORC Y369 369 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive C:1 0.05 1 1 luad:1 ENST00000318247 6 3d RORC R374 374 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive C:2 0.05 2 2 stad:1|ucec:1 ENST00000318247 6 3d RORC T375 375 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive M:1 0.05 1 1 kirp:1 ENST00000318247 6 3d RORC M385 385 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive I:1 0.05 1 1 skcm:1 ENST00000318247 6 3d RORC F401 401 517 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4wpf_D(0.0668);4nie_A(0.0713);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);3l0l_A(0.05);4nb6_A(0.0549);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive L:1 0.05 1 1 skcm:1 ENST00000318247 6 3d RORC R374 374 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive C:2 0.05 2 2 stad:1|ucec:1 ENST00000318247 6 3d RORC G383 383 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive D:1 0.05 1 1 stad:1 ENST00000318247 6 3d RORC M385 385 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive I:1 0.05 1 1 skcm:1 ENST00000318247 6 3d RORC S398 398 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive N:1 0.05 1 1 stad:1 ENST00000318247 6 3d RORC F401 401 518 4wlb_A(0.0574);4qm0_C(0.0592);4nie_B(0.0735);4s14_A(0.0562);4nie_A(0.0713);4wpf_D(0.0668);4qm0_A(0.0702);3l0j_A(0.0604);4nb6_B(0.0519);4wpf_A(0.0724);4wlb_B(0.0533);4nb6_A(0.0549);3l0l_A(0.05);3l0l_B(0.0709);4ymq_A(0.0565);3kyt_A(0.0666);4wqp_B(0.0572);4wqp_A(0.0666);3b0w_B(0.0824);3b0w_A(0.0805) Cluster-exclusive L:1 0.05 1 1 skcm:1 ENST00000318247 6 3d ITGB1 M149 149 523 3vi3_D(0.0502) Cluster-exclusive V:1|I:1|L:1 0.0502 3 3 brca:1|skcm:1|lusc:1 ENST00000302278 3 3d ITGB1 D158 158 523 3vi3_D(0.0502) Cluster-exclusive N:3 0.0502 3 2 coadread:1|hnsc:2 ENST00000302278 3 3d ITGB1 V162 162 523 3vi3_D(0.0502) Cluster-exclusive G:1 0.0502 1 1 hnsc:1 ENST00000302278 3 3d ITGB1 V275 275 523 3vi3_D(0.0502) Cluster-exclusive G:2 0.0502 2 2 brca:1|mmyl:1 ENST00000302278 3 3d SYT14 Q317 317 524 3hhc_A(0.0504) Cluster-exclusive H:1 0.0504 1 1 blca:1 ENST00000472886 1 3d SYT14 L411 411 524 3hhc_A(0.0504) Cluster-exclusive V:1 0.0504 1 1 brca:1 ENST00000472886 1 3d SYT14 E412 412 524 3hhc_A(0.0504) Cluster-exclusive Q:1|D:1 0.0504 2 2 esca:1|luad:1 ENST00000472886 1 3d SYT14 G414 414 524 3hhc_A(0.0504) Cluster-exclusive D:1 0.0504 1 1 cscc:1 ENST00000472886 1 3d SYT14 S415 415 524 3hhc_A(0.0504) Cluster-exclusive A:1 0.0504 1 1 ov:1 ENST00000472886 1 3d SYT14 S410 410 525 3hhc_B(0.057);3hhc_A(0.0504) Cluster-exclusive Y:1 0.0504 1 1 ucec:1 ENST00000472886 1 3d SYT14 L411 411 525 3hhc_B(0.057);3hhc_A(0.0504) Cluster-exclusive V:1 0.0504 1 1 brca:1 ENST00000472886 1 3d SYT14 E412 412 525 3hhc_B(0.057);3hhc_A(0.0504) Cluster-exclusive Q:1|D:1 0.0504 2 2 esca:1|luad:1 ENST00000472886 1 3d SYT14 G414 414 525 3hhc_B(0.057);3hhc_A(0.0504) Cluster-exclusive D:1 0.0504 1 1 cscc:1 ENST00000472886 1 3d SYT14 S415 415 525 3hhc_B(0.057);3hhc_A(0.0504) Cluster-exclusive A:1 0.0504 1 1 ov:1 ENST00000472886 1 3d SYT14 P378 378 526 3hhc_A(0.0504) Cluster-exclusive L:1 0.0504 1 1 cscc:1 ENST00000472886 1 3d SYT14 S410 410 526 3hhc_A(0.0504) Cluster-exclusive Y:1 0.0504 1 1 ucec:1 ENST00000472886 1 3d SYT14 L411 411 526 3hhc_A(0.0504) Cluster-exclusive V:1 0.0504 1 1 brca:1 ENST00000472886 1 3d SYT14 E412 412 526 3hhc_A(0.0504) Cluster-exclusive Q:1|D:1 0.0504 2 2 esca:1|luad:1 ENST00000472886 1 3d SYT14 G414 414 526 3hhc_A(0.0504) Cluster-exclusive D:1 0.0504 1 1 cscc:1 ENST00000472886 1 3d TRPV1 A209 209 527 2wa0_A(0.0506) Cluster-exclusive T:2 0.0506 2 2 coadread:1|ucec:1 ENST00000399756 4 3d TRPV1 R212 212 527 2wa0_A(0.0506) Cluster-exclusive K:1 0.0506 1 1 brca:1 ENST00000399756 4 3d TRPV1 R213 213 527 2wa0_A(0.0506) Cluster-exclusive H:2 0.0506 2 2 coadread:1|stad:1 ENST00000399756 4 3d TRPV1 A209 209 528 2wa0_A(0.0506) Cluster-exclusive T:2 0.0506 2 2 coadread:1|ucec:1 ENST00000399756 4 3d TRPV1 G225 225 528 2wa0_A(0.0506) Cluster-exclusive R:1 0.0506 1 1 paad:1 ENST00000399756 4 3d TRPV1 Q229 229 528 2wa0_A(0.0506) Cluster-exclusive H:1 0.0506 1 1 paad:1 ENST00000399756 4 3d ACOT4 P310 310 530 3k2i_B(0.052);3k2i_A(0.0507) Cluster-exclusive S:2|L:1 0.0507 3 2 skcm:2|cscc:1 ENST00000326303 4 3d ACOT4 E312 312 530 3k2i_B(0.052);3k2i_A(0.0507) Cluster-exclusive Q:1|K:2 0.0507 3 3 brca:1|skcm:1|cscc:1 ENST00000326303 4 3d ACOT4 R341 341 530 3k2i_B(0.052);3k2i_A(0.0507) Cluster-exclusive Q:1|W:1 0.0507 2 2 coadread:1|hnsc:1 ENST00000326303 4 3d RHOA T37 37 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot-linked S:1|I:1 0.051 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot-linked C:1 0.051 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot Q:6|K:1 0.051 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot-linked K:1 0.051 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot C:7|S:2|F:1|I:1 0.051 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot-linked V:4 0.051 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 532 1z2c_A(0.051);1kmq_A(0.0711);3kz1_F(0.0648);1tx4_B(0.0709);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1cxz_A(0.0631);1s1c_A(0.0679) Hotspot-linked G:1|Y:1|N:1 0.051 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d RHOA L22 22 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot-linked P:1|R:1 0.051 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA I23 23 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot-linked R:1 0.051 1 1 lymbc:1 ENST00000418115 1 3d RHOA E40 40 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot Q:6|K:1 0.051 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot-linked K:1 0.051 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot C:7|S:2|F:1|I:1 0.051 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot-linked V:4 0.051 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 533 1z2c_A(0.051);1kmq_A(0.0711);1tx4_B(0.0709);3kz1_F(0.0648);3kz1_E(0.0683);2gcp_A(0.0626);3msx_A(0.072);1ow3_B(0.0631);1cxz_A(0.0631);1s1c_B(0.0688);1a2b_A(0.0595);1s1c_A(0.0679) Hotspot-linked G:1|Y:1|N:1 0.051 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d HBA2 H123 123 537 1aj9_A(0.0968);1z8u_D(0.0592);1abw_A(0.0647);1z8u_B(0.063);3d7o_A(0.0992);1c7d_A(0.0606);1aby_A(0.062);1c7c_A(0.0567);4ij2_A(0.0973);1jy7_C(0.0962);1lft_A(0.099);1qi8_A(0.096);1yff_C(0.0983);2w72_A(0.09);2w72_C(0.0996);1a9w_C(0.0958);1jy7_P(0.0972);1jy7_W(0.0996);1jy7_U(0.0947);1uiw_E(0.0979);1o1j_A(0.0512);1o1i_A(0.0975);1uiw_C(0.0972);1o1l_A(0.0524);1uiw_A(0.0934);1hbs_E(0.0951);1o1n_A(0.0513);1o1m_A(0.0527);1o1p_A(0.064);3ia3_B(0.0587);1y01_B(0.0949);4ij2_C(0.0925);3ia3_D(0.0572);1r1x_A(0.0989);1j7s_A(0.0969);4n7n_I(0.0977) Cluster-exclusive Y:1 0.0512 1 1 hnsc:1 ENST00000251595 6 3d HBA2 S125 125 537 1aj9_A(0.0968);1z8u_D(0.0592);1abw_A(0.0647);1z8u_B(0.063);3d7o_A(0.0992);1c7d_A(0.0606);1aby_A(0.062);1c7c_A(0.0567);4ij2_A(0.0973);1jy7_C(0.0962);1lft_A(0.099);1qi8_A(0.096);1yff_C(0.0983);2w72_A(0.09);2w72_C(0.0996);1a9w_C(0.0958);1jy7_P(0.0972);1jy7_W(0.0996);1jy7_U(0.0947);1uiw_E(0.0979);1o1j_A(0.0512);1o1i_A(0.0975);1uiw_C(0.0972);1o1l_A(0.0524);1uiw_A(0.0934);1hbs_E(0.0951);1o1n_A(0.0513);1o1m_A(0.0527);1o1p_A(0.064);3ia3_B(0.0587);1y01_B(0.0949);4ij2_C(0.0925);3ia3_D(0.0572);1r1x_A(0.0989);1j7s_A(0.0969);4n7n_I(0.0977) Cluster-exclusive F:1 0.0512 1 1 luad:1 ENST00000251595 6 3d HBA2 L126 126 537 1aj9_A(0.0968);1z8u_D(0.0592);1abw_A(0.0647);1z8u_B(0.063);3d7o_A(0.0992);1c7d_A(0.0606);1aby_A(0.062);1c7c_A(0.0567);4ij2_A(0.0973);1jy7_C(0.0962);1lft_A(0.099);1qi8_A(0.096);1yff_C(0.0983);2w72_A(0.09);2w72_C(0.0996);1a9w_C(0.0958);1jy7_P(0.0972);1jy7_W(0.0996);1jy7_U(0.0947);1uiw_E(0.0979);1o1j_A(0.0512);1o1i_A(0.0975);1uiw_C(0.0972);1o1l_A(0.0524);1uiw_A(0.0934);1hbs_E(0.0951);1o1n_A(0.0513);1o1m_A(0.0527);1o1p_A(0.064);3ia3_B(0.0587);1y01_B(0.0949);4ij2_C(0.0925);3ia3_D(0.0572);1r1x_A(0.0989);1j7s_A(0.0969);4n7n_I(0.0977) Cluster-exclusive M:1 0.0512 1 1 hnsc:1 ENST00000251595 6 3d HBA2 D127 127 537 1aj9_A(0.0968);1z8u_D(0.0592);1abw_A(0.0647);1z8u_B(0.063);3d7o_A(0.0992);1c7d_A(0.0606);1aby_A(0.062);1c7c_A(0.0567);4ij2_A(0.0973);1jy7_C(0.0962);1lft_A(0.099);1qi8_A(0.096);1yff_C(0.0983);2w72_A(0.09);2w72_C(0.0996);1a9w_C(0.0958);1jy7_P(0.0972);1jy7_W(0.0996);1jy7_U(0.0947);1uiw_E(0.0979);1o1j_A(0.0512);1o1i_A(0.0975);1uiw_C(0.0972);1o1l_A(0.0524);1uiw_A(0.0934);1hbs_E(0.0951);1o1n_A(0.0513);1o1m_A(0.0527);1o1p_A(0.064);3ia3_B(0.0587);1y01_B(0.0949);4ij2_C(0.0925);3ia3_D(0.0572);1r1x_A(0.0989);1j7s_A(0.0969);4n7n_I(0.0977) Cluster-exclusive Y:1 0.0512 1 1 brca:1 ENST00000251595 6 3d KEAP1 R415 415 538 3wn7_A(0.0513) Cluster-exclusive C:1|H:1 0.0513 2 1 luad:2 ENST00000171111 5 3d KEAP1 G429 429 538 3wn7_A(0.0513) Cluster-exclusive S:1|V:1 0.0513 2 2 hnsc:1|luad:1 ENST00000171111 5 3d KEAP1 G430 430 538 3wn7_A(0.0513) Cluster-exclusive V:1 0.0513 1 1 luad:1 ENST00000171111 5 3d KEAP1 R460 460 538 3wn7_A(0.0513) Cluster-exclusive G:1 0.0513 1 1 luad:1 ENST00000171111 5 3d KEAP1 I461 461 538 3wn7_A(0.0513) Cluster-exclusive V:1 0.0513 1 1 luad:1 ENST00000171111 5 3d ZIC1 A314 314 540 2dmo_A(0.0513) Cluster-exclusive V:1|G:1 0.0513 2 2 lusc:1|luad:1 ENST00000282928 4 3d ZIC1 R315 315 540 2dmo_A(0.0513) Cluster-exclusive P:1|C:1 0.0513 2 2 stad:1|luad:1 ENST00000282928 4 3d ZIC1 S316 316 540 2dmo_A(0.0513) Cluster-exclusive C:2 0.0513 2 2 hnsc:1|luad:1 ENST00000282928 4 3d ZIC1 H326 326 540 2dmo_A(0.0513) Cluster-exclusive Q:1 0.0513 1 1 lusm:1 ENST00000282928 4 3d ZIC1 T327 327 540 2dmo_A(0.0513) Cluster-exclusive K:1 0.0513 1 1 luad:1 ENST00000282928 4 3d ZIC1 F332 332 540 2dmo_A(0.0513) Cluster-exclusive C:1 0.0513 1 1 lusc:1 ENST00000282928 4 3d ZIC1 K333 333 540 2dmo_A(0.0513) Cluster-exclusive N:1 0.0513 1 1 lihc:1 ENST00000282928 4 3d ITGA1 M276 276 544 2b2x_A(0.0517) Cluster-exclusive I:1 0.0517 1 1 skcm:1 ENST00000282588 6 3d ITGA1 Q303 303 544 2b2x_A(0.0517) Cluster-exclusive E:1 0.0517 1 1 prad:1 ENST00000282588 6 3d ITGA1 R304 304 544 2b2x_A(0.0517) Cluster-exclusive Q:1 0.0517 1 1 gbm:1 ENST00000282588 6 3d ITGA1 S306 306 544 2b2x_A(0.0517) Cluster-exclusive F:1 0.0517 1 1 skcm:1 ENST00000282588 6 3d ITGA1 S329 329 544 2b2x_A(0.0517) Cluster-exclusive L:1 0.0517 1 1 skcm:1 ENST00000282588 6 3d ITGA1 A331 331 544 2b2x_A(0.0517) Cluster-exclusive S:1 0.0517 1 1 mcl:1 ENST00000282588 6 3d ITGA1 H338 338 544 2b2x_A(0.0517) Cluster-exclusive P:1 0.0517 1 1 paad:1 ENST00000282588 6 3d SMAD4 L57 57 547 3qsv_A(0.0524) Cluster-exclusive V:1 0.0524 1 1 coadread:1 ENST00000342988 3 3d SMAD4 Y95 95 547 3qsv_A(0.0524) Cluster-exclusive C:1 0.0524 1 1 luad:1 ENST00000342988 3 3d SMAD4 A96 96 547 3qsv_A(0.0524) Cluster-exclusive D:1 0.0524 1 1 paad:1 ENST00000342988 3 3d SMAD4 W99 99 547 3qsv_A(0.0524) Cluster-exclusive C:1 0.0524 1 1 hnsc:1 ENST00000342988 3 3d SMAD4 R100 100 547 3qsv_A(0.0524) Cluster-exclusive W:1 0.0524 1 1 luad:1 ENST00000342988 3 3d SMAD4 P130 130 547 3qsv_A(0.0524) Cluster-exclusive L:1 0.0524 1 1 paad:1 ENST00000342988 3 3d SMAD4 Y131 131 547 3qsv_A(0.0524) Cluster-exclusive C:1 0.0524 1 1 paad:1 ENST00000342988 3 3d SMAD4 H132 132 547 3qsv_A(0.0524) Cluster-exclusive Y:2 0.0524 2 1 brca:2 ENST00000342988 3 3d SMAD4 Y133 133 547 3qsv_A(0.0524) Cluster-exclusive N:1 0.0524 1 1 blca:1 ENST00000342988 3 3d PTPN11 E69 69 548 4fr4_D(0.0556);4fr4_C(0.0526);4fr4_E(0.0539);4fr4_B(0.0572);4fr4_A(0.0539) Hotspot-linked D:1|K:3 0.0526 4 3 coadread:2|gbm:1|pias:1 ENST00000351677 2 3d PTPN11 F71 71 548 4fr4_D(0.0556);4fr4_C(0.0526);4fr4_E(0.0539);4fr4_B(0.0572);4fr4_A(0.0539) Hotspot-linked L:3 0.0526 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 548 4fr4_D(0.0556);4fr4_C(0.0526);4fr4_E(0.0539);4fr4_B(0.0572);4fr4_A(0.0539) Hotspot T:3|D:2|V:2 0.0526 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d CCL7 R53 53 549 1ncv_A(0.0529) Cluster-exclusive K:2 0.0529 2 2 skcm:1|cscc:1 ENST00000378569 2 3d CCL7 R61 61 549 1ncv_A(0.0529) Cluster-exclusive W:3 0.0529 3 2 coadread:2|skcm:1 ENST00000378569 2 3d CCL7 A63 63 549 1ncv_A(0.0529) Cluster-exclusive D:1 0.0529 1 1 gbm:1 ENST00000378569 2 3d CCL7 I65 65 549 1ncv_A(0.0529) Cluster-exclusive L:1 0.0529 1 1 skcm:1 ENST00000378569 2 3d CCL7 A76 76 549 1ncv_A(0.0529) Cluster-exclusive T:1 0.0529 1 1 lusc:1 ENST00000378569 2 3d CCL7 D77 77 549 1ncv_A(0.0529) Cluster-exclusive Y:1 0.0529 1 1 ucec:1 ENST00000378569 2 3d PIK3R1 Y452 452 551 3hiz_B(0.0532) Cluster-exclusive C:2|H:1|N:1 0.0532 4 3 esca:1|hnsc:1|ucec:2 ENST00000274335 5 3d PIK3R1 D569 569 551 3hiz_B(0.0532) Hotspot-linked G:1 0.0532 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 551 3hiz_B(0.0532) Hotspot-linked P:1 0.0532 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 551 3hiz_B(0.0532) Hotspot-linked R:1 0.0532 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 551 3hiz_B(0.0532) Hotspot-linked P:3 0.0532 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 551 3hiz_B(0.0532) Hotspot-linked T:1|I:2 0.0532 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d PIK3R1 T576 576 551 3hiz_B(0.0532) Cluster-exclusive M:1 0.0532 1 1 esca:1 ENST00000274335 5 3d PIK3R1 R577 577 551 3hiz_B(0.0532) Cluster-exclusive G:1 0.0532 1 1 lihc:1 ENST00000274335 5 3d PTPN11 D61 61 552 4je4_A(0.0533) Hotspot-linked Y:1|N:1 0.0533 2 2 laml:1|nbl:1 ENST00000351677 2 3d PTPN11 F71 71 552 4je4_A(0.0533) Hotspot-linked L:3 0.0533 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 552 4je4_A(0.0533) Hotspot T:3|D:2|V:2 0.0533 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 E76 76 552 4je4_A(0.0533) Hotspot A:2|G:1|K:4 0.0533 7 5 mmyl:2|coadread:2|nbl:1|lusc:1|pias:1 ENST00000351677 2 3d FGF9 G80 80 553 1ihk_A(0.0533) Cluster-exclusive D:1 0.0533 1 1 stad:1 ENST00000382353 5 3d FGF9 T81 81 553 1ihk_A(0.0533) Cluster-exclusive S:1 0.0533 1 1 hnsc:1 ENST00000382353 5 3d FGF9 I82 82 553 1ihk_A(0.0533) Cluster-exclusive V:1 0.0533 1 1 luad:1 ENST00000382353 5 3d FGF9 L124 124 553 1ihk_A(0.0533) Cluster-exclusive M:1 0.0533 1 1 skcm:1 ENST00000382353 5 3d FGF9 G126 126 553 1ihk_A(0.0533) Cluster-exclusive R:1 0.0533 1 1 cscc:1 ENST00000382353 5 3d FGF9 S127 127 553 1ihk_A(0.0533) Cluster-exclusive T:1 0.0533 1 1 prad:1 ENST00000382353 5 3d FGF9 E128 128 553 1ihk_A(0.0533) Cluster-exclusive K:1 0.0533 1 1 skcm:1 ENST00000382353 5 3d CUL5 V185 185 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive I:1 0.0535 1 1 lusc:1 ENST00000393094 2 3d CUL5 N186 186 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive K:1 0.0535 1 1 skcm:1 ENST00000393094 2 3d CUL5 L187 187 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive R:1 0.0535 1 1 nbl:1 ENST00000393094 2 3d CUL5 C188 188 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive F:1 0.0535 1 1 ov:1 ENST00000393094 2 3d CUL5 K194 194 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive T:1 0.0535 1 1 gbm:1 ENST00000393094 2 3d CUL5 R253 253 556 2wzk_A(0.0558);4jgh_D(0.0535) Cluster-exclusive Q:1 0.0535 1 1 ucec:1 ENST00000393094 2 3d TP53 C238 238 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0538 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot S:8|D:6|T:1 0.0538 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot-linked R:1|G:2 0.0538 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0538 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0538 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot-linked R:2|V:3|I:5 0.0538 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot-linked I:4 0.0538 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0538 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 V272 272 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot E:1|G:4|K:1|L:1|M:17 0.0538 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot P:4|C:119|S:5|H:103|L:22 0.0538 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 558 3d09_A(0.0673);3d08_A(0.0648);3d06_A(0.0538);3d0a_A(0.0696) Hotspot A:4|D:5|F:7|G:4|L:1 0.0538 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d SLIT2 R456 456 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive C:1|H:1 0.0538 2 2 stad:1|mcl:1 ENST00000504154 1 3d SLIT2 P460 460 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive S:1 0.0538 1 1 skcm:1 ENST00000504154 1 3d SLIT2 R467 467 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive G:1|I:2|K:1 0.0538 4 4 ucs:1|skcm:1|ucec:1|luad:1 ENST00000504154 1 3d SLIT2 A502 502 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive V:1 0.0538 1 1 luad:1 ENST00000504154 1 3d SLIT2 A505 505 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive V:1 0.0538 1 1 skcm:1 ENST00000504154 1 3d SLIT2 A536 536 559 3ee6_A(0.0538);3edy_A(0.0574) Cluster-exclusive V:1 0.0538 1 1 cscc:1 ENST00000504154 1 3d CSF1 F67 67 561 4adf_S(0.066);4adf_U(0.0538);4adf_T(0.0689);4adf_G(0.0638);4adf_I(0.0611);4adf_X(0.0625);4adf_H(0.0658);4adf_K(0.0653);3uez_E(0.0688);4adf_J(0.0713) Cluster-exclusive S:1 0.0538 1 1 paad:1 ENST00000329608 6 3d CSF1 F69 69 561 4adf_S(0.066);4adf_U(0.0538);4adf_T(0.0689);4adf_G(0.0638);4adf_I(0.0611);4adf_X(0.0625);4adf_H(0.0658);4adf_K(0.0653);3uez_E(0.0688);4adf_J(0.0713) Cluster-exclusive L:1 0.0538 1 1 coadread:1 ENST00000329608 6 3d CSF1 D71 71 561 4adf_S(0.066);4adf_U(0.0538);4adf_T(0.0689);4adf_G(0.0638);4adf_I(0.0611);4adf_X(0.0625);4adf_H(0.0658);4adf_K(0.0653);3uez_E(0.0688);4adf_J(0.0713) Cluster-exclusive H:1 0.0538 1 1 brca:1 ENST00000329608 6 3d CSF1 L88 88 561 4adf_S(0.066);4adf_U(0.0538);4adf_T(0.0689);4adf_G(0.0638);4adf_I(0.0611);4adf_X(0.0625);4adf_H(0.0658);4adf_K(0.0653);3uez_E(0.0688);4adf_J(0.0713) Cluster-exclusive M:1 0.0538 1 1 ucec:1 ENST00000329608 6 3d CSF1 V135 135 561 4adf_S(0.066);4adf_U(0.0538);4adf_T(0.0689);4adf_G(0.0638);4adf_I(0.0611);4adf_X(0.0625);4adf_H(0.0658);4adf_K(0.0653);3uez_E(0.0688);4adf_J(0.0713) Cluster-exclusive I:1 0.0538 1 1 ov:1 ENST00000329608 6 3d TGFBI T504 504 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive N:1 0.0539 1 1 ucec:1 ENST00000442011 2 3d TGFBI V505 505 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive F:1 0.0539 1 1 esca:1 ENST00000442011 2 3d TGFBI D507 507 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive V:1 0.0539 1 1 ucec:1 ENST00000442011 2 3d TGFBI V508 508 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive I:1 0.0539 1 1 luad:1 ENST00000442011 2 3d TGFBI L509 509 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive P:2 0.0539 2 2 coadread:1|lihc:1 ENST00000442011 2 3d TGFBI L531 531 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive V:1 0.0539 1 1 hnsc:1 ENST00000442011 2 3d TGFBI V625 625 562 2vxp_B(0.0583);2vxp_A(0.0539) Cluster-exclusive A:1 0.0539 1 1 acc:1 ENST00000442011 2 3d STARD5 L50 50 564 2r55_B(0.058);2r55_A(0.054) Cluster-exclusive M:1 0.054 1 1 gbm:1 ENST00000302824 6 3d STARD5 F175 175 564 2r55_B(0.058);2r55_A(0.054) Cluster-exclusive L:1 0.054 1 1 cesc:1 ENST00000302824 6 3d STARD5 F176 176 564 2r55_B(0.058);2r55_A(0.054) Cluster-exclusive L:1 0.054 1 1 blca:1 ENST00000302824 6 3d STARD5 H177 177 564 2r55_B(0.058);2r55_A(0.054) Cluster-exclusive R:1 0.054 1 1 blca:1 ENST00000302824 6 3d C2ORF16 D1105 1105 570 1rh2_A(0.0544) Cluster-exclusive N:1 0.0544 1 1 skcm:1 ENST00000408964 2 3d C2ORF16 V1106 1106 570 1rh2_A(0.0544) Cluster-exclusive A:1 0.0544 1 1 ucec:1 ENST00000408964 2 3d BRAF H574 574 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot-linked Q:1|N:1 0.0546 2 1 luad:2 ENST00000288602 6 3d BRAF N581 581 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot S:7|T:2|H:1|I:1 0.0546 11 6 mmyl:1|coadread:1|ov:1|skcm:4|kirp:1|luad:3 ENST00000288602 6 3d BRAF D594 594 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot G:6|H:1|N:5 0.0546 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot-linked L:1 0.0546 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot R:2|S:1|D:1|V:1 0.0546 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF K601 601 574 4g9r_B(0.0557);1uwj_A(0.055);4g9r_A(0.0581);1uwj_B(0.0546) Hotspot T:1|E:12|N:2 0.0546 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d TP53 C238 238 575 2pcx_A(0.0547) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0547 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 575 2pcx_A(0.0547) Hotspot S:8|D:6|T:1 0.0547 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 575 2pcx_A(0.0547) Hotspot-linked R:1|G:2 0.0547 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 575 2pcx_A(0.0547) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0547 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 575 2pcx_A(0.0547) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0547 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 575 2pcx_A(0.0547) Hotspot-linked R:2|V:3|I:5 0.0547 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 575 2pcx_A(0.0547) Hotspot-linked I:4 0.0547 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 575 2pcx_A(0.0547) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0547 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R273 273 575 2pcx_A(0.0547) Hotspot P:4|C:119|S:5|H:103|L:22 0.0547 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 575 2pcx_A(0.0547) Hotspot A:4|D:5|F:7|G:4|L:1 0.0547 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 575 2pcx_A(0.0547) Hotspot R:1|S:4|F:10|Y:15 0.0547 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d ZNF98 G496 496 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive A:1|D:1 0.0547 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive I:1 0.0547 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive T:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive V:1 0.0547 1 1 ucec:1 ENST00000357774 5 3d ZNF98 N500 500 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive T:1 0.0547 1 1 coadread:1 ENST00000357774 5 3d ZNF98 Q501 501 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive K:1 0.0547 1 1 npc:1 ENST00000357774 5 3d ZNF98 H504 504 576 3brt_B(0.0594);3brv_B(0.0547);3brt_D(0.063);3brv_D(0.0723) Cluster-exclusive N:1 0.0547 1 1 lusc:1 ENST00000357774 5 3d ZNF98 C492 492 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive F:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 E493 493 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive G:1 0.0547 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive Q:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive A:1|D:1 0.0547 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive I:1 0.0547 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 577 3brt_B(0.0594);3brt_D(0.063);3brv_B(0.0547);3brv_D(0.0723) Cluster-exclusive T:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 C492 492 578 3brv_B(0.0547) Cluster-exclusive F:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 E493 493 578 3brv_B(0.0547) Cluster-exclusive G:1 0.0547 1 1 paad:1 ENST00000357774 5 3d ZNF98 E494 494 578 3brv_B(0.0547) Cluster-exclusive Q:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 G496 496 578 3brv_B(0.0547) Cluster-exclusive A:1|D:1 0.0547 2 2 esca:1|lihc:1 ENST00000357774 5 3d ZNF98 K497 497 578 3brv_B(0.0547) Cluster-exclusive I:1 0.0547 1 1 kich:1 ENST00000357774 5 3d ZNF98 A498 498 578 3brv_B(0.0547) Cluster-exclusive T:1 0.0547 1 1 luad:1 ENST00000357774 5 3d ZNF98 F499 499 578 3brv_B(0.0547) Cluster-exclusive V:1 0.0547 1 1 ucec:1 ENST00000357774 5 3d TP53 Y163 163 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot C:27|D:2|H:4|N:4 0.0551 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 V173 173 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot A:2|E:1|G:2|L:15|M:12 0.0551 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot-linked S:1|W:2|K:1 0.0551 4 1 lihc:4 ENST00000269305 4 3d TP53 L194 194 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot P:2|R:15|F:3|H:3 0.0551 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 C238 238 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0551 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot S:8|D:6|T:1 0.0551 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot-linked R:1|G:2 0.0551 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0551 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot R:1|C:8|S:5|D:9|V:2 0.0551 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0551 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot-linked R:2|V:3|I:5 0.0551 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot-linked I:4 0.0551 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0551 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0551 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot-linked S:2|F:1|N:3 0.0551 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V274 274 581 2ata_B(0.0848);2ata_A(0.0927);3igl_A(0.0775);4qo1_B(0.0815);4mzi_A(0.0551);1kzy_A(0.0946);1kzy_B(0.0936);2ahi_A(0.0882);2ahi_B(0.0932);3kmd_D(0.0881);3kmd_B(0.0934);3kmd_C(0.0899);2ahi_D(0.0931);3kmd_A(0.0843);1tup_A(0.0919);4ibq_B(0.089);4ibq_A(0.0865);4ibq_D(0.0874);4ibq_C(0.0937);4ibu_B(0.0825);4ibu_A(0.0832);4ibu_D(0.0919);4ibu_C(0.0874);4ibw_A(0.0777);2ata_C(0.0936);2xwr_B(0.0752);4lo9_D(0.0814);2xwr_A(0.0872);1gzh_A(0.0838);4lo9_C(0.0825);2ac0_A(0.0943);2ac0_B(0.0875);1gzh_C(0.0928);4hje_D(0.0922);4hje_C(0.0912);4hje_B(0.0922);3ts8_A(0.0595);4hje_A(0.0901);2ady_A(0.0908);2ady_B(0.0913);4ibz_D(0.088);4kvp_D(0.0869);4kvp_C(0.0842);4ibz_B(0.0928);4kvp_A(0.0863);1ycs_A(0.0987);1tsr_A(0.092);3q05_A(0.0579);4ijt_A(0.0804);2ocj_D(0.0822);2ac0_C(0.092);2ac0_D(0.0998);3kz8_B(0.0869);3kz8_A(0.0884);4ibz_A(0.0879) Hotspot A:4|D:5|F:7|G:4|L:1 0.0551 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d ABCB1 R467 467 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive W:5|L:1 0.0553 6 4 prad:2|mbl:1|lihc:1|ucec:2 ENST00000265724 3 3d ABCB1 E468 468 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive K:3 0.0553 3 1 skcm:3 ENST00000265724 3 3d ABCB1 R492 492 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive L:1 0.0553 1 1 luad:1 ENST00000265724 3 3d ABCB1 R543 543 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive H:1 0.0553 1 1 ucec:1 ENST00000265724 3 3d ABCB1 L545 545 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive Q:1 0.0553 1 1 acc:1 ENST00000265724 3 3d ABCB1 R547 547 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive C:2 0.0553 2 2 hnsc:1|skcm:1 ENST00000265724 3 3d ABCB1 N548 548 582 4m1m_A(0.0609);4m2s_A(0.0952);4m2t_A(0.0919);3g5u_A(0.0647);4m1m_B(0.0553);3g60_A(0.0934) Cluster-exclusive K:1 0.0553 1 1 luad:1 ENST00000265724 3 3d BRAF S467 467 584 4wo5_A(0.0555) Hotspot-linked L:2 0.0555 2 1 skcm:2 ENST00000288602 6 3d BRAF H574 574 584 4wo5_A(0.0555) Hotspot-linked Q:1|N:1 0.0555 2 1 luad:2 ENST00000288602 6 3d BRAF F595 595 584 4wo5_A(0.0555) Hotspot-linked L:1 0.0555 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 584 4wo5_A(0.0555) Hotspot R:2|S:1|D:1|V:1 0.0555 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 584 4wo5_A(0.0555) Hotspot Q:2|R:1|S:1 0.0555 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 584 4wo5_A(0.0555) Hotspot R:4|E:509|K:32 0.0555 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 584 4wo5_A(0.0555) Hotspot T:1|E:12|N:2 0.0555 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d HGFAC V458 458 585 3k2u_A(0.0558) Cluster-exclusive I:1 0.0558 1 1 gbm:1 ENST00000382774 3 3d HGFAC S459 459 585 3k2u_A(0.0558) Cluster-exclusive F:1 0.0558 1 1 skcm:1 ENST00000382774 3 3d HGFAC V460 460 585 3k2u_A(0.0558) Cluster-exclusive M:1 0.0558 1 1 stad:1 ENST00000382774 3 3d HGFAC G478 478 585 3k2u_A(0.0558) Cluster-exclusive D:1 0.0558 1 1 stad:1 ENST00000382774 3 3d RORC Y369 369 586 4s14_A(0.0562) Cluster-exclusive C:1 0.0562 1 1 luad:1 ENST00000318247 6 3d RORC R374 374 586 4s14_A(0.0562) Cluster-exclusive C:2 0.0562 2 2 stad:1|ucec:1 ENST00000318247 6 3d RORC T375 375 586 4s14_A(0.0562) Cluster-exclusive M:1 0.0562 1 1 kirp:1 ENST00000318247 6 3d RORC F377 377 586 4s14_A(0.0562) Cluster-exclusive Y:1 0.0562 1 1 skcm:1 ENST00000318247 6 3d RORC F401 401 586 4s14_A(0.0562) Cluster-exclusive L:1 0.0562 1 1 skcm:1 ENST00000318247 6 3d TGFBI T504 504 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive N:1 0.0565 1 1 ucec:1 ENST00000442011 2 3d TGFBI V505 505 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive F:1 0.0565 1 1 esca:1 ENST00000442011 2 3d TGFBI D507 507 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive V:1 0.0565 1 1 ucec:1 ENST00000442011 2 3d TGFBI V508 508 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive I:1 0.0565 1 1 luad:1 ENST00000442011 2 3d TGFBI L531 531 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive V:1 0.0565 1 1 hnsc:1 ENST00000442011 2 3d TGFBI R533 533 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive L:1 0.0565 1 1 mbl:1 ENST00000442011 2 3d TGFBI T621 621 587 2vxp_B(0.0613);2vxp_A(0.0565) Cluster-exclusive P:1 0.0565 1 1 skcm:1 ENST00000442011 2 3d PBRM1 M731 731 589 4q0n_G(0.0652);4q0n_F(0.0673);4q0n_E(0.06);4q0n_D(0.0565);4q0n_H(0.0677);4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);3mb4_A(0.0987);3g0j_A(0.0565);3g0j_B(0.0687);3mb4_B(0.0883) Cluster-exclusive K:1 0.0565 1 1 luad:1 ENST00000394830 3 3d PBRM1 N734 734 589 4q0n_G(0.0652);4q0n_F(0.0673);4q0n_E(0.06);4q0n_D(0.0565);4q0n_H(0.0677);4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);3mb4_A(0.0987);3g0j_A(0.0565);3g0j_B(0.0687);3mb4_B(0.0883) Cluster-exclusive D:1 0.0565 1 1 skcm:1 ENST00000394830 3 3d PBRM1 A735 735 589 4q0n_G(0.0652);4q0n_F(0.0673);4q0n_E(0.06);4q0n_D(0.0565);4q0n_H(0.0677);4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);3mb4_A(0.0987);3g0j_A(0.0565);3g0j_B(0.0687);3mb4_B(0.0883) Cluster-exclusive V:1 0.0565 1 1 skcm:1 ENST00000394830 3 3d PBRM1 N739 739 589 4q0n_G(0.0652);4q0n_F(0.0673);4q0n_E(0.06);4q0n_D(0.0565);4q0n_H(0.0677);4q0n_C(0.0615);4q0o_A(0.0911);4q0n_B(0.062);4q0n_A(0.0604);3mb4_A(0.0987);3g0j_A(0.0565);3g0j_B(0.0687);3mb4_B(0.0883) Cluster-exclusive S:1 0.0565 1 1 luad:1 ENST00000394830 3 3d RAB33B T117 117 591 1z06_A(0.0566) Cluster-exclusive A:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d RAB33B K149 149 591 1z06_A(0.0566) Cluster-exclusive N:1 0.0566 1 1 skcm:1 ENST00000305626 5 3d RAB33B L152 152 591 1z06_A(0.0566) Cluster-exclusive F:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d RAB33B I156 156 591 1z06_A(0.0566) Cluster-exclusive M:1 0.0566 1 1 hnsc:1 ENST00000305626 5 3d MTOR A1459 1459 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked P:1 0.0568 1 1 kirc:1 ENST00000361445 4 3d MTOR L1460 1460 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked P:2 0.0568 2 1 kirc:2 ENST00000361445 4 3d MTOR V1461 1461 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked L:1 0.0568 1 1 ov:1 ENST00000361445 4 3d MTOR Y1463 1463 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked S:1 0.0568 1 1 kirc:1 ENST00000361445 4 3d MTOR K1465 1465 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked N:1 0.0568 1 1 luad:1 ENST00000361445 4 3d MTOR M1467 1467 592 4iwo_A(0.0665);4im3_A(0.0629);4im2_A(0.0663);4iw0_A(0.0568);4iwq_A(0.0602);4iwp_A(0.0586);4im0_A(0.0664) Hotspot-linked I:1 0.0568 1 1 cesc:1 ENST00000361445 4 3d ACP1 L14 14 594 1phr_A(0.0629);1xww_A(0.057);1c0e_A(0.0586) Cluster-exclusive V:1 0.057 1 1 kirc:1 ENST00000272065 5 3d ACP1 R19 19 594 1phr_A(0.0629);1xww_A(0.057);1c0e_A(0.0586) Cluster-exclusive Q:1 0.057 1 1 coadread:1 ENST00000272065 5 3d ACP1 I128 128 594 1phr_A(0.0629);1xww_A(0.057);1c0e_A(0.0586) Cluster-exclusive F:1 0.057 1 1 stad:1 ENST00000272065 5 3d ACP1 E129 129 594 1phr_A(0.0629);1xww_A(0.057);1c0e_A(0.0586) Cluster-exclusive Q:1 0.057 1 1 luad:1 ENST00000272065 5 3d ACP1 D130 130 594 1phr_A(0.0629);1xww_A(0.057);1c0e_A(0.0586) Cluster-exclusive E:1 0.057 1 1 ucec:1 ENST00000272065 5 3d RBBP7 E313 313 596 3c9c_A(0.0572) Cluster-exclusive K:2 0.0572 2 1 coadread:2 ENST00000380087 2 3d RBBP7 S314 314 596 3c9c_A(0.0572) Cluster-exclusive Y:1 0.0572 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 596 3c9c_A(0.0572) Cluster-exclusive Y:1 0.0572 1 1 skcm:1 ENST00000380087 2 3d RBBP7 D317 317 596 3c9c_A(0.0572) Cluster-exclusive N:1 0.0572 1 1 cesc:1 ENST00000380087 2 3d RBBP7 G336 336 596 3c9c_A(0.0572) Cluster-exclusive D:1 0.0572 1 1 stad:1 ENST00000380087 2 3d RBBP7 R340 340 596 3c9c_A(0.0572) Cluster-exclusive C:1|H:2 0.0572 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d BRAF G466 466 599 4dbn_B(0.0574) Hotspot A:1|E:6|V:10 0.0574 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 599 4dbn_B(0.0574) Hotspot-linked L:2 0.0574 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 599 4dbn_B(0.0574) Hotspot A:9|R:3|S:1|E:2|V:6 0.0574 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF D594 594 599 4dbn_B(0.0574) Hotspot G:6|H:1|N:5 0.0574 12 9 acc:1|mmyl:2|coadread:1|cll:1|blca:1|hnsc:1|skcm:1|lgg:1|luad:3 ENST00000288602 6 3d BRAF F595 595 599 4dbn_B(0.0574) Hotspot-linked L:1 0.0574 1 1 blca:1 ENST00000288602 6 3d SLIT2 R456 456 600 3edy_A(0.0574) Cluster-exclusive C:1|H:1 0.0574 2 2 stad:1|mcl:1 ENST00000504154 1 3d SLIT2 S459 459 600 3edy_A(0.0574) Cluster-exclusive 0.0574 1 ENST00000504154 1 3d SLIT2 P460 460 600 3edy_A(0.0574) Cluster-exclusive S:1 0.0574 1 1 skcm:1 ENST00000504154 1 3d SLIT2 R461 461 600 3edy_A(0.0574) Cluster-exclusive C:2 0.0574 2 2 paad:1|prad:1 ENST00000504154 1 3d SLIT2 R462 462 600 3edy_A(0.0574) Cluster-exclusive C:3 0.0574 3 3 acc:1|cll:1|lihc:1 ENST00000504154 1 3d SLIT2 N465 465 600 3edy_A(0.0574) Cluster-exclusive S:1 0.0574 1 1 luad:1 ENST00000504154 1 3d SLIT2 R467 467 600 3edy_A(0.0574) Cluster-exclusive G:1|I:2|K:1 0.0574 4 4 ucs:1|skcm:1|ucec:1|luad:1 ENST00000504154 1 3d SLIT2 A505 505 600 3edy_A(0.0574) Cluster-exclusive V:1 0.0574 1 1 skcm:1 ENST00000504154 1 3d SLIT2 A536 536 600 3edy_A(0.0574) Cluster-exclusive V:1 0.0574 1 1 cscc:1 ENST00000504154 1 3d CAMK1 T114 114 601 4fgb_A(0.0576) Cluster-exclusive M:2 0.0576 2 1 coadread:2 ENST00000256460 3 3d CAMK1 E115 115 601 4fgb_A(0.0576) Cluster-exclusive K:1 0.0576 1 1 skcm:1 ENST00000256460 3 3d CAMK1 L212 212 601 4fgb_A(0.0576) Cluster-exclusive P:1 0.0576 1 1 stad:1 ENST00000256460 3 3d CAMK1 I286 286 601 4fgb_A(0.0576) Cluster-exclusive V:1 0.0576 1 1 kirp:1 ENST00000256460 3 3d TTK E571 571 603 4jt3_A(0.058);3cek_A(0.0747);3vqu_A(0.0664);3gfw_A(0.0689);3hmp_A(0.0706);4bi1_A(0.0668);3wyy_A(0.0668);3hmo_A(0.0699);3hmn_A(0.0666);2zmc_A(0.0718);4c4i_A(0.0757) Cluster-exclusive K:4 0.058 4 4 coadread:1|hnsc:1|skcm:1|ucec:1 ENST00000369798 2 3d TTK A573 573 603 4jt3_A(0.058);3cek_A(0.0747);3vqu_A(0.0664);3gfw_A(0.0689);3hmp_A(0.0706);4bi1_A(0.0668);3wyy_A(0.0668);3hmo_A(0.0699);3hmn_A(0.0666);2zmc_A(0.0718);4c4i_A(0.0757) Cluster-exclusive V:1 0.058 1 1 coadread:1 ENST00000369798 2 3d TTK L575 575 603 4jt3_A(0.058);3cek_A(0.0747);3vqu_A(0.0664);3gfw_A(0.0689);3hmp_A(0.0706);4bi1_A(0.0668);3wyy_A(0.0668);3hmo_A(0.0699);3hmn_A(0.0666);2zmc_A(0.0718);4c4i_A(0.0757) Cluster-exclusive F:1|W:1 0.058 2 1 luad:2 ENST00000369798 2 3d TTK G666 666 603 4jt3_A(0.058);3cek_A(0.0747);3vqu_A(0.0664);3gfw_A(0.0689);3hmp_A(0.0706);4bi1_A(0.0668);3wyy_A(0.0668);3hmo_A(0.0699);3hmn_A(0.0666);2zmc_A(0.0718);4c4i_A(0.0757) Cluster-exclusive R:1|E:1 0.058 2 2 brca:1|gbm:1 ENST00000369798 2 3d TTK A668 668 603 4jt3_A(0.058);3cek_A(0.0747);3vqu_A(0.0664);3gfw_A(0.0689);3hmp_A(0.0706);4bi1_A(0.0668);3wyy_A(0.0668);3hmo_A(0.0699);3hmn_A(0.0666);2zmc_A(0.0718);4c4i_A(0.0757) Cluster-exclusive E:1 0.058 1 1 lgg:1 ENST00000369798 2 3d FGF9 G80 80 609 1g82_B(0.0587) Cluster-exclusive D:1 0.0587 1 1 stad:1 ENST00000382353 5 3d FGF9 I82 82 609 1g82_B(0.0587) Cluster-exclusive V:1 0.0587 1 1 luad:1 ENST00000382353 5 3d FGF9 G117 117 609 1g82_B(0.0587) Cluster-exclusive W:1 0.0587 1 1 skcm:1 ENST00000382353 5 3d FGF9 L124 124 609 1g82_B(0.0587) Cluster-exclusive M:1 0.0587 1 1 skcm:1 ENST00000382353 5 3d FGF9 G126 126 609 1g82_B(0.0587) Cluster-exclusive R:1 0.0587 1 1 cscc:1 ENST00000382353 5 3d FGF9 S127 127 609 1g82_B(0.0587) Cluster-exclusive T:1 0.0587 1 1 prad:1 ENST00000382353 5 3d FGF9 E128 128 609 1g82_B(0.0587) Cluster-exclusive K:1 0.0587 1 1 skcm:1 ENST00000382353 5 3d TP53 C176 176 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0588 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0588 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 C238 238 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0588 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot S:8|D:6|T:1 0.0588 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot-linked R:1|G:2 0.0588 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0588 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0588 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot-linked I:1 0.0588 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot R:1|C:8|S:5|D:9|V:2 0.0588 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0588 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot-linked R:2|V:3|I:5 0.0588 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot-linked I:4 0.0588 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 611 2ata_B(0.0902);2ata_A(0.0972);3igl_A(0.0825);3d09_A(0.0853);4qo1_B(0.0857);4mzi_A(0.0588);1kzy_A(0.1);1kzy_B(0.0986);2ahi_A(0.0929);2ahi_B(0.0982);3kmd_D(0.0937);3kmd_B(0.0977);3kmd_C(0.0944);3kmd_A(0.0887);2ahi_D(0.0968);3q06_A(0.0633);4ibq_B(0.0939);4ibq_A(0.0902);4ibq_D(0.0925);4ibs_B(0.0932);4ibs_A(0.0919);4ibq_C(0.0987);4ibu_B(0.0871);4ibs_D(0.0897);4ibs_C(0.0914);4ibu_A(0.0873);4ibu_D(0.0967);4ibu_C(0.0931);4ibw_A(0.0824);2ata_C(0.0997);2xwr_B(0.0788);3igk_A(0.0828);4lo9_B(0.0921);3d08_A(0.0846);4lo9_A(0.0871);4lo9_D(0.086);2xwr_A(0.0924);4lo9_C(0.0872);1gzh_A(0.087);3d06_A(0.0699);2ac0_A(0.0991);1gzh_C(0.0976);2ac0_B(0.0917);4hje_D(0.0976);4hje_C(0.096);4hje_B(0.0968);3ts8_A(0.0629);4hje_A(0.0956);3d0a_D(0.0989);3d0a_C(0.0923);3d0a_B(0.0893);3d0a_A(0.0931);2ady_A(0.0955);2ady_B(0.096);4ibz_D(0.0924);4kvp_D(0.0906);4kvp_C(0.0883);4ibz_B(0.0973);4ibz_C(0.0887);4kvp_B(0.0834);4kvp_A(0.0911);3q05_A(0.0603);2ocj_D(0.0868);4ijt_A(0.0843);2ocj_C(0.0968);2ac0_C(0.0972);3q01_A(0.0679);4ibt_A(0.0847);2ybg_C(0.0967);2ocj_B(0.0945);4ibt_C(0.088);3kz8_B(0.0919);3kz8_A(0.0933);2ocj_A(0.0888);4ibt_B(0.0809);4ibt_D(0.0913) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0588 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d ATP1A3 R340 340 612 3a3y_A(0.0588) Cluster-exclusive C:1 0.0588 1 1 gbm:1 ENST00000302102 5 3d ATP1A3 M341 341 612 3a3y_A(0.0588) Cluster-exclusive I:1 0.0588 1 1 lusc:1 ENST00000302102 5 3d ATP1A3 R343 343 612 3a3y_A(0.0588) Cluster-exclusive Q:1 0.0588 1 1 ucec:1 ENST00000302102 5 3d ATP1A3 K344 344 612 3a3y_A(0.0588) Cluster-exclusive M:1|N:1 0.0588 2 2 stad:1|lihc:1 ENST00000302102 5 3d ATP1A3 N345 345 612 3a3y_A(0.0588) Cluster-exclusive T:1 0.0588 1 1 acc:1 ENST00000302102 5 3d ATP1A3 D742 742 612 3a3y_A(0.0588) Cluster-exclusive N:1 0.0588 1 1 skcm:1 ENST00000302102 5 3d ATP1A3 R340 340 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive C:1 0.0588 1 1 gbm:1 ENST00000302102 5 3d ATP1A3 M341 341 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive I:1 0.0588 1 1 lusc:1 ENST00000302102 5 3d ATP1A3 R343 343 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive Q:1 0.0588 1 1 ucec:1 ENST00000302102 5 3d ATP1A3 K344 344 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive M:1|N:1 0.0588 2 2 stad:1|lihc:1 ENST00000302102 5 3d ATP1A3 N345 345 613 3a3y_A(0.0588);2zxe_A(0.0635) Cluster-exclusive T:1 0.0588 1 1 acc:1 ENST00000302102 5 3d PTEN M35 35 614 1d5r_A(0.059) Hotspot-linked I:1 0.059 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 614 1d5r_A(0.059) Hotspot-linked R:2|E:1 0.059 3 1 gbm:3 ENST00000371953 3 3d PTEN P38 38 614 1d5r_A(0.059) Cluster-exclusive S:3|F:1|L:1 0.059 5 2 ucs:1|skcm:4 ENST00000371953 3 3d PTEN L70 70 614 1d5r_A(0.059) Hotspot-linked H:1 0.059 1 1 gbm:1 ENST00000371953 3 3d PTEN C71 71 614 1d5r_A(0.059) Hotspot-linked Y:3 0.059 3 2 gbm:2|ucec:1 ENST00000371953 3 3d PTEN A121 121 614 1d5r_A(0.059) Cluster-exclusive T:1 0.059 1 1 lgg:1 ENST00000371953 3 3d PTEN H123 123 614 1d5r_A(0.059) Hotspot-linked D:2|Y:3|L:1 0.059 6 6 brca:1|gbm:1|ov:1|ucec:1|kirc:1|luad:1 ENST00000371953 3 3d PTEN C124 124 614 1d5r_A(0.059) Hotspot-linked R:1|S:1|G:1 0.059 3 2 brca:2|ucec:1 ENST00000371953 3 3d PTEN K125 125 614 1d5r_A(0.059) Hotspot-linked T:1|N:1 0.059 2 2 coadread:1|kirc:1 ENST00000371953 3 3d PTEN T131 131 614 1d5r_A(0.059) Hotspot-linked A:1 0.059 1 1 gbm:1 ENST00000371953 3 3d CDKN2C Q43 43 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive H:1 0.0591 1 1 coadread:1 ENST00000262662 1 3d CDKN2C D64 64 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive N:1 0.0591 1 1 ov:1 ENST00000262662 1 3d CDKN2C K66 66 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive E:1 0.0591 1 1 ucec:1 ENST00000262662 1 3d CDKN2C D67 67 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive N:1 0.0591 1 1 thca:1 ENST00000262662 1 3d CDKN2C A72 72 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive T:1 0.0591 1 1 esca:1 ENST00000262662 1 3d CDKN2C E99 99 615 1ihb_B(0.068);1ihb_A(0.0743);1g3n_B(0.064);1mx6_A(0.0648);1mx6_B(0.0591);1g3n_F(0.0635);1mx2_A(0.0613);1mx2_B(0.0643);1mx4_A(0.0688);1mx4_B(0.0624) Cluster-exclusive K:1 0.0591 1 1 lusc:1 ENST00000262662 1 3d CDKN2C R39 39 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive T:1 0.0591 1 1 kirc:1 ENST00000262662 1 3d CDKN2C Q43 43 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive H:1 0.0591 1 1 coadread:1 ENST00000262662 1 3d CDKN2C K66 66 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive E:1 0.0591 1 1 ucec:1 ENST00000262662 1 3d CDKN2C D67 67 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive N:1 0.0591 1 1 thca:1 ENST00000262662 1 3d CDKN2C T69 69 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive A:1 0.0591 1 1 hnsc:1 ENST00000262662 1 3d CDKN2C A72 72 616 1ihb_B(0.068);1mx6_B(0.0591) Cluster-exclusive T:1 0.0591 1 1 esca:1 ENST00000262662 1 3d POLM R229 229 624 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive P:1|W:2 0.0604 3 1 ucec:3 ENST00000242248 5 3d POLM R233 233 624 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive M:1 0.0604 1 1 kirc:1 ENST00000242248 5 3d POLM Y234 234 624 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive C:1 0.0604 1 1 coadread:1 ENST00000242248 5 3d POLM Q235 235 624 4lzg_A(0.0608);4lzd_A(0.0641);4m04_A(0.0604);4m0a_A(0.0642) Cluster-exclusive H:1 0.0604 1 1 paad:1 ENST00000242248 5 3d RHOA L22 22 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot-linked P:1|R:1 0.061 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA F39 39 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot-linked C:1 0.061 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot Q:6|K:1 0.061 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot-linked K:1 0.061 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot C:7|S:2|F:1|I:1 0.061 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot-linked V:4 0.061 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 625 3lwn_A(0.0704);3lwn_B(0.0727);4d0n_A(0.0707);3lxr_A(0.071);1xcg_B(0.0674);3t06_B(0.0677);3lw8_A(0.061);3lw8_B(0.0665);1lb1_F(0.0757);3t06_F(0.0679);3lw8_C(0.0631);1lb1_H(0.0708);3lw8_D(0.066);3tvd_A(0.0643);1lb1_B(0.0749);1lb1_D(0.0688);1xcg_F(0.0726);1dpf_A(0.0642);1x86_D(0.0721);1x86_B(0.0636);4xh9_E(0.0656);1x86_F(0.0668);4xh9_B(0.0678) Hotspot-linked G:1|Y:1|N:1 0.061 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d KMT2C P350 350 627 2ysm_A(0.061) Cluster-exclusive R:1 0.061 1 1 kirc:1 ENST00000262189 6 3d KMT2C G351 351 627 2ysm_A(0.061) Cluster-exclusive E:2 0.061 2 2 hnsc:1|skcm:1 ENST00000262189 6 3d KMT2C D352 352 627 2ysm_A(0.061) Cluster-exclusive Y:1 0.061 1 1 paad:1 ENST00000262189 6 3d KMT2C L353 353 627 2ysm_A(0.061) Cluster-exclusive F:1|H:1 0.061 2 2 lusc:1|luad:1 ENST00000262189 6 3d KMT2C Q356 356 627 2ysm_A(0.061) Cluster-exclusive E:1|K:2|L:1 0.061 4 2 blca:1|luad:3 ENST00000262189 6 3d KMT2C F357 357 627 2ysm_A(0.061) Cluster-exclusive L:1 0.061 1 1 luad:1 ENST00000262189 6 3d KMT2C Y366 366 627 2ysm_A(0.061) Cluster-exclusive S:1 0.061 1 1 ov:1 ENST00000262189 6 3d KMT2C H367 367 627 2ysm_A(0.061) Cluster-exclusive D:2|Y:3 0.061 5 3 brca:2|skcm:2|lihc:1 ENST00000262189 6 3d KMT2C G368 368 627 2ysm_A(0.061) Cluster-exclusive R:1|V:1 0.061 2 2 blca:1|lusc:1 ENST00000262189 6 3d GRB2 F95 95 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive V:1 0.0614 1 1 brca:1 ENST00000316804 5 3d GRB2 R112 112 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive Q:1 0.0614 1 1 skcm:1 ENST00000316804 5 3d GRB2 D113 113 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive H:1 0.0614 1 1 all:1 ENST00000316804 5 3d GRB2 G116 116 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive R:1|W:1 0.0614 2 2 coadread:1|lihc:1 ENST00000316804 5 3d GRB2 K117 117 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive R:1 0.0614 1 1 ucec:1 ENST00000316804 5 3d GRB2 Y118 118 628 3in7_A(0.0993);1fyr_A(0.0751);2aob_B(0.0753);2h5k_A(0.0695);1jyu_A(0.0614);1zfp_E(0.0923) Cluster-exclusive S:1 0.0614 1 1 mmyl:1 ENST00000316804 5 3d HRAS A11 11 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot-linked D:1 0.0619 1 1 hnsc:1 ENST00000451590 1 3d HRAS G12 12 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot A:2|C:3|S:10|D:8|V:1|N:1 0.0619 25 4 acc:1|hnsc:16|blca:6|cscc:2 ENST00000451590 1 3d HRAS T58 58 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot-linked I:1 0.0619 1 1 cscc:1 ENST00000451590 1 3d HRAS A59 59 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot-linked T:1 0.0619 1 1 ucec:1 ENST00000451590 1 3d HRAS G60 60 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot-linked S:1 0.0619 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 630 3lbn_A(0.0723);3rs5_A(0.081);1p2s_A(0.0639);3rs3_A(0.0724);1p2u_A(0.0635);3lbh_A(0.0739);3rs7_A(0.0715);3kud_A(0.0803);3v4f_A(0.073);3l8z_A(0.0719);4dlt_A(0.0689);221p_A(0.0672);4dlv_A(0.0787);1nvv_Q(0.0619);4dlx_A(0.0718);1xd2_A(0.0741);4dlr_A(0.072);1ctq_A(0.0693);1qra_A(0.0736);4nyi_Q(0.0681);1gnr_A(0.0714);4nym_Q(0.0661);2cl7_X(0.0696);3ddc_A(0.0764);1gnp_A(0.0749);3rrz_A(0.0791);5p21_A(0.0636);3rs0_A(0.0751);3rso_A(0.0807);3rs4_A(0.0752);4efl_A(0.0729);3rs2_A(0.0782);1p2t_A(0.0649);3lbi_A(0.0769);1p2v_A(0.0725);1wq1_R(0.0705);6q21_B(0.0644);3l8y_A(0.0844);4dls_A(0.081);6q21_A(0.0673);1k8r_A(0.0679);4dlu_A(0.0713);6q21_C(0.0693);4g0n_A(0.0738);4dlw_A(0.0715);4dly_A(0.0697);1nvw_Q(0.0702);2evw_X(0.0626);1iaq_B(0.0642);3k8y_A(0.0716);1iaq_C(0.0647);4nyj_Q(0.0672);3kkn_A(0.0677);1lfd_D(0.0721);1lfd_B(0.0747);2cl6_X(0.0752);1gnq_A(0.0674);3k9n_A(0.0708);3k9l_A(0.0717);3rry_A(0.0788);3i3s_R(0.0652);4dlz_A(0.0778);121p_A(0.0721);2clc_X(0.0682);2cl0_X(0.0704);3rsl_A(0.0646) Hotspot R:19|H:2|K:10|L:9 0.0619 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d EGFR L858 858 632 2gs7_A(0.0778);4hjo_A(0.079);2gs7_B(0.0622) Hotspot R:30 0.0622 30 1 luad:30 ENST00000275493 2 3d EGFR L861 861 632 2gs7_A(0.0778);4hjo_A(0.079);2gs7_B(0.0622) Hotspot Q:7 0.0622 7 2 lusc:2|luad:5 ENST00000275493 2 3d RBP2 E18 18 635 1b4m_A(0.0623) Cluster-exclusive D:1|G:1 0.0623 2 2 gbm:1|kirp:1 ENST00000232217 2 3d RBP2 M21 21 635 1b4m_A(0.0623) Cluster-exclusive K:1|L:1 0.0623 2 1 stad:2 ENST00000232217 2 3d RBP2 A23 23 635 1b4m_A(0.0623) Cluster-exclusive S:1|T:1 0.0623 2 2 paad:1|lusc:1 ENST00000232217 2 3d RBP2 I26 26 635 1b4m_A(0.0623) Cluster-exclusive T:1 0.0623 1 1 blca:1 ENST00000232217 2 3d RBP2 F28 28 635 1b4m_A(0.0623) Cluster-exclusive S:1 0.0623 1 1 ucec:1 ENST00000232217 2 3d EGFR R831 831 636 2jiu_B(0.0625);2jit_B(0.0638) Hotspot-linked H:2 0.0625 2 2 coadread:1|luad:1 ENST00000275493 2 3d EGFR R832 832 636 2jiu_B(0.0625);2jit_B(0.0638) Hotspot-linked C:1|H:1 0.0625 2 2 ucec:1|kirc:1 ENST00000275493 2 3d EGFR L833 833 636 2jiu_B(0.0625);2jit_B(0.0638) Hotspot-linked F:1|V:1 0.0625 2 1 luad:2 ENST00000275493 2 3d EGFR L858 858 636 2jiu_B(0.0625);2jit_B(0.0638) Hotspot R:30 0.0625 30 1 luad:30 ENST00000275493 2 3d EGFR L861 861 636 2jiu_B(0.0625);2jit_B(0.0638) Hotspot Q:7 0.0625 7 2 lusc:2|luad:5 ENST00000275493 2 3d TP53 Q331 331 637 3sak_B(0.0697);3sak_A(0.0712);3sak_D(0.0692);3sak_C(0.0628);1sal_D(0.0764);1sal_C(0.0762);1sak_D(0.0649);1sal_B(0.0724);1sak_C(0.0662);1sak_B(0.0645);1sal_A(0.071);1sak_A(0.0663);1saf_D(0.0748);1sae_D(0.0737);1saf_C(0.0761);1saf_B(0.0724);1sae_C(0.0686);1sae_B(0.0747);1saf_A(0.0699);1sae_A(0.0706);1olg_B(0.07);1olh_A(0.0744);1olh_B(0.0705);1olg_C(0.0636);1olh_C(0.0684);1olg_D(0.0687);1olh_D(0.0716);1olg_A(0.0703) Cluster-exclusive H:7 0.0628 7 6 paad:1|coadread:1|hnsc:2|ov:1|lusc:1|luad:1 ENST00000269305 4 3d TP53 R333 333 637 3sak_B(0.0697);3sak_A(0.0712);3sak_D(0.0692);3sak_C(0.0628);1sal_D(0.0764);1sal_C(0.0762);1sak_D(0.0649);1sal_B(0.0724);1sak_C(0.0662);1sak_B(0.0645);1sal_A(0.071);1sak_A(0.0663);1saf_D(0.0748);1sae_D(0.0737);1saf_C(0.0761);1saf_B(0.0724);1sae_C(0.0686);1sae_B(0.0747);1saf_A(0.0699);1sae_A(0.0706);1olg_B(0.07);1olh_A(0.0744);1olh_B(0.0705);1olg_C(0.0636);1olh_C(0.0684);1olg_D(0.0687);1olh_D(0.0716);1olg_A(0.0703) Cluster-exclusive P:1 0.0628 1 1 stad:1 ENST00000269305 4 3d TP53 G334 334 637 3sak_B(0.0697);3sak_A(0.0712);3sak_D(0.0692);3sak_C(0.0628);1sal_D(0.0764);1sal_C(0.0762);1sak_D(0.0649);1sal_B(0.0724);1sak_C(0.0662);1sak_B(0.0645);1sal_A(0.071);1sak_A(0.0663);1saf_D(0.0748);1sae_D(0.0737);1saf_C(0.0761);1saf_B(0.0724);1sae_C(0.0686);1sae_B(0.0747);1saf_A(0.0699);1sae_A(0.0706);1olg_B(0.07);1olh_A(0.0744);1olh_B(0.0705);1olg_C(0.0636);1olh_C(0.0684);1olg_D(0.0687);1olh_D(0.0716);1olg_A(0.0703) Cluster-exclusive A:1|V:3|W:1 0.0628 5 2 stad:1|luad:4 ENST00000269305 4 3d TP53 R337 337 637 3sak_B(0.0697);3sak_A(0.0712);3sak_D(0.0692);3sak_C(0.0628);1sal_D(0.0764);1sal_C(0.0762);1sak_D(0.0649);1sal_B(0.0724);1sak_C(0.0662);1sak_B(0.0645);1sal_A(0.071);1sak_A(0.0663);1saf_D(0.0748);1sae_D(0.0737);1saf_C(0.0761);1saf_B(0.0724);1sae_C(0.0686);1sae_B(0.0747);1saf_A(0.0699);1sae_A(0.0706);1olg_B(0.07);1olh_A(0.0744);1olh_B(0.0705);1olg_C(0.0636);1olh_C(0.0684);1olg_D(0.0687);1olh_D(0.0716);1olg_A(0.0703) Cluster-exclusive P:2|C:18|S:2|H:4|L:9 0.0628 35 16 acc:1|brca:2|paad:2|coadread:5|esca:1|hnsc:5|laml:1|ov:1|lihc:1|lusc:2|lgg:1|kich:1|prad:1|stad:2|cesc:1|luad:8 ENST00000269305 4 3d TP53 F338 338 637 3sak_B(0.0697);3sak_A(0.0712);3sak_D(0.0692);3sak_C(0.0628);1sal_D(0.0764);1sal_C(0.0762);1sak_D(0.0649);1sal_B(0.0724);1sak_C(0.0662);1sak_B(0.0645);1sal_A(0.071);1sak_A(0.0663);1saf_D(0.0748);1sae_D(0.0737);1saf_C(0.0761);1saf_B(0.0724);1sae_C(0.0686);1sae_B(0.0747);1saf_A(0.0699);1sae_A(0.0706);1olg_B(0.07);1olh_A(0.0744);1olh_B(0.0705);1olg_C(0.0636);1olh_C(0.0684);1olg_D(0.0687);1olh_D(0.0716);1olg_A(0.0703) Cluster-exclusive I:1|L:1 0.0628 2 2 kich:1|stad:1 ENST00000269305 4 3d PTEN D24 24 642 1d5r_A(0.063) Cluster-exclusive E:1|V:1|G:1|H:1|N:1 0.063 5 4 brca:1|stad:2|ucs:1|ucec:1 ENST00000371953 3 3d PTEN L25 25 642 1d5r_A(0.063) Cluster-exclusive V:1|F:2 0.063 3 2 gbm:2|lgg:1 ENST00000371953 3 3d PTEN I28 28 642 1d5r_A(0.063) Hotspot-linked S:1|F:1|M:1 0.063 3 3 brca:1|coadread:1|stad:1 ENST00000371953 3 3d PTEN I33 33 642 1d5r_A(0.063) Cluster-exclusive S:1 0.063 1 1 ucec:1 ENST00000371953 3 3d PTEN A34 34 642 1d5r_A(0.063) Hotspot-linked V:1 0.063 1 1 ucec:1 ENST00000371953 3 3d PTEN M35 35 642 1d5r_A(0.063) Hotspot-linked I:1 0.063 1 1 luad:1 ENST00000371953 3 3d PTEN G36 36 642 1d5r_A(0.063) Hotspot-linked R:2|E:1 0.063 3 1 gbm:3 ENST00000371953 3 3d PTEN T131 131 642 1d5r_A(0.063) Hotspot-linked A:1 0.063 1 1 gbm:1 ENST00000371953 3 3d PTEN I135 135 642 1d5r_A(0.063) Hotspot-linked K:1 0.063 1 1 brca:1 ENST00000371953 3 3d PTEN Y155 155 642 1d5r_A(0.063) Hotspot-linked C:2 0.063 2 2 ucs:1|ucec:1 ENST00000371953 3 3d PTEN R159 159 642 1d5r_A(0.063) Hotspot-linked S:1|K:1 0.063 2 1 gbm:2 ENST00000371953 3 3d H3C10 A2 2 649 4hsu_C(0.0639);4gu0_E(0.0715) Cluster-exclusive S:1|V:1|G:1 0.0639 3 3 acc:1|brca:1|mmyl:1 ENST00000369163 2 3d H3C10 T4 4 649 4hsu_C(0.0639);4gu0_E(0.0715) Cluster-exclusive A:1 0.0639 1 1 lusm:1 ENST00000369163 2 3d H3C10 Q6 6 649 4hsu_C(0.0639);4gu0_E(0.0715) Cluster-exclusive H:2 0.0639 2 2 hnsc:1|luad:1 ENST00000369163 2 3d H3C10 R9 9 649 4hsu_C(0.0639);4gu0_E(0.0715) Cluster-exclusive G:1 0.0639 1 1 ov:1 ENST00000369163 2 3d ACACA T138 138 650 2hjw_A(0.064) Cluster-exclusive I:1 0.064 1 1 nbl:1 ENST00000613687 3d ACACA S173 173 650 2hjw_A(0.064) Cluster-exclusive C:1 0.064 1 1 ucs:1 ENST00000613687 3d TP53 C238 238 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0645 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot-linked R:1|G:2 0.0645 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0645 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0645 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M246 246 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot-linked R:2|V:3|I:5 0.0645 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot-linked I:4 0.0645 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0645 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 V272 272 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot E:1|G:4|K:1|L:1|M:17 0.0645 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot P:4|C:119|S:5|H:103|L:22 0.0645 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 653 2bip_A(0.0645);2biq_A(0.0685) Hotspot A:4|D:5|F:7|G:4|L:1 0.0645 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d CEP164 Q229 229 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive R:1 0.065 1 1 lihc:1 ENST00000278935 3 3d CEP164 C324 324 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive F:1 0.065 1 1 prad:1 ENST00000278935 3 3d CEP164 R325 325 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive W:1 0.065 1 1 lihc:1 ENST00000278935 3 3d CEP164 N326 326 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive Y:1 0.065 1 1 luad:1 ENST00000278935 3 3d CEP164 V328 328 657 2w1g_A(0.0665);4jaj_A(0.0716);2w1c_A(0.0733);4dee_A(0.065) Cluster-exclusive G:1 0.065 1 1 skcm:1 ENST00000278935 3 3d EGFR R252 252 663 1yy9_A(0.0659);1nql_A(0.0672);3qwq_A(0.0694) Hotspot-linked P:3|C:3|H:2 0.0659 8 3 stad:2|gbm:3|lgg:3 ENST00000275493 2 3d EGFR A289 289 663 1yy9_A(0.0659);1nql_A(0.0672);3qwq_A(0.0694) Hotspot D:3|T:6|V:17|I:1|N:1 0.0659 28 3 gbm:24|hnsc:1|lgg:3 ENST00000275493 2 3d MAP2K1 F53 53 664 3sls_B(0.0662);3zlw_A(0.0723);3eqi_A(0.0758) Hotspot V:1|I:1|L:4 0.0662 6 4 coadread:3|stad:1|skcm:1|luad:1 ENST00000307102 5 3d MAP2K1 K57 57 664 3sls_B(0.0662);3zlw_A(0.0723);3eqi_A(0.0758) Hotspot T:3|N:7 0.0662 10 6 prad:1|stad:1|dlbc:1|hnsc:1|skcm:2|luad:4 ENST00000307102 5 3d MAP2K1 G128 128 664 3sls_B(0.0662);3zlw_A(0.0723);3eqi_A(0.0758) Hotspot-linked D:2|V:1 0.0662 3 2 coadread:2|luad:1 ENST00000307102 5 3d MAP2K1 Y130 130 664 3sls_B(0.0662);3zlw_A(0.0723);3eqi_A(0.0758) Hotspot-linked C:2 0.0662 2 2 dlbc:1|lihc:1 ENST00000307102 5 3d MAP2K1 A132 132 664 3sls_B(0.0662);3zlw_A(0.0723);3eqi_A(0.0758) Hotspot-linked V:1 0.0662 1 1 coadread:1 ENST00000307102 5 3d PAXIP1 F874 874 665 4fxg_A(0.0663) Cluster-exclusive L:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 E875 875 665 4fxg_A(0.0663) Cluster-exclusive K:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 P876 876 665 4fxg_A(0.0663) Cluster-exclusive S:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 K885 885 665 4fxg_A(0.0663) Cluster-exclusive E:1 0.0663 1 1 hnsc:1 ENST00000397192 1 3d PAXIP1 Y887 887 665 4fxg_A(0.0663) Cluster-exclusive C:1 0.0663 1 1 mmyl:1 ENST00000397192 1 3d PAXIP1 T872 872 666 4fxg_A(0.0663) Cluster-exclusive S:1 0.0663 1 1 luad:1 ENST00000397192 1 3d PAXIP1 F874 874 666 4fxg_A(0.0663) Cluster-exclusive L:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 E875 875 666 4fxg_A(0.0663) Cluster-exclusive K:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 P876 876 666 4fxg_A(0.0663) Cluster-exclusive S:1 0.0663 1 1 coadread:1 ENST00000397192 1 3d PAXIP1 K885 885 666 4fxg_A(0.0663) Cluster-exclusive E:1 0.0663 1 1 hnsc:1 ENST00000397192 1 3d TBL1XR1 D370 370 672 2y9t_A(0.067) Cluster-exclusive N:1 0.067 1 1 coadread:1 ENST00000430069 1 3d TBL1XR1 K374 374 672 2y9t_A(0.067) Cluster-exclusive N:2 0.067 2 2 stad:1|luad:1 ENST00000430069 1 3d TBL1XR1 I375 375 672 2y9t_A(0.067) Cluster-exclusive K:1 0.067 1 1 hnsc:1 ENST00000430069 1 3d TBL1XR1 W376 376 672 2y9t_A(0.067) Cluster-exclusive L:1 0.067 1 1 blca:1 ENST00000430069 1 3d TBL1XR1 N382 382 672 2y9t_A(0.067) Cluster-exclusive S:1 0.067 1 1 brca:1 ENST00000430069 1 3d TBL1XR1 Y395 395 672 2y9t_A(0.067) Cluster-exclusive H:1 0.067 1 1 coadread:1 ENST00000430069 1 3d PPP2R1A T145 145 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked P:1 0.0673 1 1 ov:1 ENST00000322088 6 3d PPP2R1A L173 173 675 3dw8_D(0.0794);2nyl_A(0.0764);2nym_A(0.0816);3dw8_A(0.0802);2nym_D(0.076);4i5l_D(0.0821);4i5n_A(0.0811);2nyl_D(0.0844);4i5n_D(0.0785);4i5l_A(0.0907);2npp_D(0.0878);2iae_A(0.0749);2ie4_A(0.0883);2pf4_B(0.0762);2pf4_A(0.0794);2npp_A(0.0818);1b3u_B(0.0673);1b3u_A(0.0742);2ie3_A(0.0824);2pkg_A(0.0846);2pkg_B(0.0874);3fga_A(0.0785);2pf4_C(0.07);3k7v_A(0.0772);3k7w_A(0.0781) Hotspot-linked M:1 0.0673 1 1 ucec:1 ENST00000322088 6 3d BRAF F595 595 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot-linked L:1 0.0679 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot R:2|S:1|D:1|V:1 0.0679 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot Q:2|R:1|S:1 0.0679 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot R:4|E:509|K:32 0.0679 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 678 4wo5_A(0.0679);4pp7_B(0.0821) Hotspot T:1|E:12|N:2 0.0679 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d PPP2R1A R183 183 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot Q:4|W:14|G:1 0.0679 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d PPP2R1A Q217 217 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot-linked K:1 0.0679 1 1 ucs:1 ENST00000322088 6 3d PPP2R1A S219 219 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot-linked L:3 0.0679 3 2 ucs:2|cscc:1 ENST00000322088 6 3d PPP2R1A V220 220 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot-linked M:1 0.0679 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A R221 221 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot-linked W:2 0.0679 2 2 stad:1|ucec:1 ENST00000322088 6 3d PPP2R1A R258 258 679 2ie4_A(0.0679);4i5l_A(0.0766);2pf4_B(0.0727);2pf4_A(0.076);3dw8_D(0.0747);2pf4_C(0.0757);4i5l_D(0.0732);1b3u_B(0.076);4i5n_A(0.073);1b3u_A(0.0721);4i5n_D(0.0727) Hotspot-linked C:1|H:3 0.0679 4 3 coadread:1|ucec:2|luad:1 ENST00000322088 6 3d VHL S80 80 682 1lqb_C(0.0691) Hotspot-linked R:2|I:1 0.0691 3 2 paad:1|kirc:2 ENST00000256474 2 3d VHL L128 128 682 1lqb_C(0.0691) Hotspot-linked H:3 0.0691 3 2 kirc:2|luad:1 ENST00000256474 2 3d VHL L129 129 682 1lqb_C(0.0691) Hotspot-linked P:1 0.0691 1 1 kirc:1 ENST00000256474 2 3d VHL V130 130 682 1lqb_C(0.0691) Hotspot-linked D:1|F:1 0.0691 2 1 kirc:2 ENST00000256474 2 3d VHL I151 151 682 1lqb_C(0.0691) Hotspot-linked T:2|F:1|N:1 0.0691 4 1 kirc:4 ENST00000256474 2 3d VHL L153 153 682 1lqb_C(0.0691) Hotspot-linked P:2 0.0691 2 1 kirc:2 ENST00000256474 2 3d ITFG1 E376 376 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive Q:1|K:1 0.0693 2 2 lusm:1|hnsc:1 ENST00000320640 6 3d ITFG1 A377 377 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive V:1 0.0693 1 1 stad:1 ENST00000320640 6 3d ITFG1 A396 396 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive V:1 0.0693 1 1 stad:1 ENST00000320640 6 3d ITFG1 M397 397 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive I:1 0.0693 1 1 luad:1 ENST00000320640 6 3d ITFG1 V398 398 685 3aad_A(0.0693);1eqf_A(0.0849);3uv5_A(0.0769) Cluster-exclusive F:1 0.0693 1 1 luad:1 ENST00000320640 6 3d MAP2K1 R49 49 692 3sls_A(0.0698) Hotspot-linked H:1 0.0698 1 1 coadread:1 ENST00000307102 5 3d MAP2K1 A52 52 692 3sls_A(0.0698) Hotspot-linked V:1 0.0698 1 1 skcm:1 ENST00000307102 5 3d MAP2K1 F53 53 692 3sls_A(0.0698) Hotspot V:1|I:1|L:4 0.0698 6 4 coadread:3|stad:1|skcm:1|luad:1 ENST00000307102 5 3d MAP2K1 Q56 56 692 3sls_A(0.0698) Hotspot-linked P:1 0.0698 1 1 luad:1 ENST00000307102 5 3d MAP2K1 K57 57 692 3sls_A(0.0698) Hotspot T:3|N:7 0.0698 10 6 prad:1|stad:1|dlbc:1|hnsc:1|skcm:2|luad:4 ENST00000307102 5 3d MAP2K1 G128 128 692 3sls_A(0.0698) Hotspot-linked D:2|V:1 0.0698 3 2 coadread:2|luad:1 ENST00000307102 5 3d PTPN11 T468 468 693 3o5x_A(0.0698);3mow_A(0.0714) Hotspot-linked M:5 0.0698 5 3 coadread:1|stad:2|skcm:2 ENST00000351677 2 3d PTPN11 S502 502 693 3o5x_A(0.0698);3mow_A(0.0714) Hotspot-linked P:1|L:1 0.0698 2 2 gbm:1|laml:1 ENST00000351677 2 3d PTPN11 Q506 506 693 3o5x_A(0.0698);3mow_A(0.0714) Hotspot-linked P:1 0.0698 1 1 skcm:1 ENST00000351677 2 3d PTPN11 T507 507 693 3o5x_A(0.0698);3mow_A(0.0714) Hotspot-linked K:2 0.0698 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 693 3o5x_A(0.0698);3mow_A(0.0714) Hotspot E:1|H:3|L:3 0.0698 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d SPOP F102 102 696 2cr2_A(0.0705) Hotspot C:2|V:2|L:1 0.0705 5 1 prad:5 ENST00000347630 2 3d SPOP K103 103 696 2cr2_A(0.0705) Hotspot-linked N:1 0.0705 1 1 ucec:1 ENST00000347630 2 3d SPOP F104 104 696 2cr2_A(0.0705) Hotspot-linked S:1|I:1 0.0705 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP M117 117 696 2cr2_A(0.0705) Hotspot-linked V:4 0.0705 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 696 2cr2_A(0.0705) Hotspot-linked R:1|N:1 0.0705 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP R121 121 696 2cr2_A(0.0705) Hotspot-linked Q:3 0.0705 3 2 ucec:2|luad:1 ENST00000347630 2 3d SPOP W131 131 696 2cr2_A(0.0705) Hotspot R:1|S:1|C:1|G:4 0.0705 7 2 prad:6|ucec:1 ENST00000347630 2 3d TP53 R175 175 699 2mej_B(0.0708) Hotspot C:4|G:7|H:143 0.0708 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 699 2mej_B(0.0708) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0708 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 699 2mej_B(0.0708) Hotspot-linked R:2|T:1|L:3 0.0708 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 S241 241 699 2mej_B(0.0708) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0708 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 699 2mej_B(0.0708) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0708 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 699 2mej_B(0.0708) Hotspot-linked I:1 0.0708 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 699 2mej_B(0.0708) Hotspot R:1|C:8|S:5|D:9|V:2 0.0708 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 699 2mej_B(0.0708) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0708 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 699 2mej_B(0.0708) Hotspot-linked R:2|V:3|I:5 0.0708 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 699 2mej_B(0.0708) Hotspot-linked I:4 0.0708 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 699 2mej_B(0.0708) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0708 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d BRAF G464 464 700 4ksq_B(0.0708) Hotspot-linked V:2 0.0708 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 700 4ksq_B(0.0708) Hotspot A:1|E:6|V:10 0.0708 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 700 4ksq_B(0.0708) Hotspot-linked L:2 0.0708 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 700 4ksq_B(0.0708) Hotspot A:9|R:3|S:1|E:2|V:6 0.0708 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF G596 596 700 4ksq_B(0.0708) Hotspot R:2|S:1|D:1|V:1 0.0708 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 700 4ksq_B(0.0708) Hotspot Q:2|R:1|S:1 0.0708 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF G466 466 704 4dbn_A(0.0713) Hotspot A:1|E:6|V:10 0.0713 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 704 4dbn_A(0.0713) Hotspot-linked L:2 0.0713 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 704 4dbn_A(0.0713) Hotspot A:9|R:3|S:1|E:2|V:6 0.0713 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 704 4dbn_A(0.0713) Hotspot-linked I:1 0.0713 1 1 paad:1 ENST00000288602 6 3d BRAF F595 595 704 4dbn_A(0.0713) Hotspot-linked L:1 0.0713 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 704 4dbn_A(0.0713) Hotspot R:2|S:1|D:1|V:1 0.0713 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 704 4dbn_A(0.0713) Hotspot Q:2|R:1|S:1 0.0713 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d IL6ST L255 255 709 1p9m_A(0.0717) Cluster-exclusive I:1 0.0717 1 1 gbc:1 ENST00000336909 5 3d IL6ST K256 256 709 1p9m_A(0.0717) Cluster-exclusive Q:1 0.0717 1 1 ucec:1 ENST00000336909 5 3d IL6ST N258 258 709 1p9m_A(0.0717) Cluster-exclusive S:2 0.0717 2 1 lihc:2 ENST00000336909 5 3d IL6ST C301 301 709 1p9m_A(0.0717) Cluster-exclusive G:1 0.0717 1 1 skcm:1 ENST00000336909 5 3d BRAF L485 485 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot-linked S:1|Y:1 0.072 2 2 skcm:1|luad:1 ENST00000288602 6 3d BRAF F595 595 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot-linked L:1 0.072 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot R:2|S:1|D:1|V:1 0.072 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot Q:2|R:1|S:1 0.072 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot R:4|E:509|K:32 0.072 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 710 3tv6_A(0.072);3skc_B(0.0832);4ehe_B(0.0742) Hotspot T:1|E:12|N:2 0.072 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d RHOA L22 22 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot-linked P:1|R:1 0.0723 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA E40 40 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot Q:6|K:1 0.0723 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot-linked K:1 0.0723 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot C:7|S:2|F:1|I:1 0.0723 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot-linked V:4 0.0723 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 711 1z2c_A(0.0723);1tx4_B(0.0993);3kz1_F(0.0945);3kz1_E(0.0982);2gcp_A(0.0876);4f38_A(0.0805);1ow3_B(0.0913);1s1c_B(0.096);1a2b_A(0.0859);1cxz_A(0.0911);1s1c_A(0.0992) Hotspot-linked G:1|Y:1|N:1 0.0723 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d AMY1C S326 326 712 1b2y_A(0.0916);3ole_A(0.0951);2cpu_A(0.0931);1kb3_A(0.0944);3old_A(0.0981);4gqr_A(0.0952);1kbk_A(0.0902);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);1xd0_A(0.0851);3bay_A(0.0913);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);1xh1_A(0.0885);3ij7_A(0.0896);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);1mfu_A(0.0986);3bai_A(0.0903);1u33_A(0.0923);2qmk_A(0.0959);3bak_A(0.0943);3baj_A(0.0824);1u30_A(0.0939);1jxj_A(0.0972);1c8q_A(0.0988);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);3cpu_A(0.092);1xcx_A(0.0892);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive Y:1 0.0723 1 1 luad:1 ENST00000370079 3 3d AMY1C I327 327 712 1b2y_A(0.0916);3ole_A(0.0951);2cpu_A(0.0931);1kb3_A(0.0944);3old_A(0.0981);4gqr_A(0.0952);1kbk_A(0.0902);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);1xd0_A(0.0851);3bay_A(0.0913);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);1xh1_A(0.0885);3ij7_A(0.0896);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);1mfu_A(0.0986);3bai_A(0.0903);1u33_A(0.0923);2qmk_A(0.0959);3bak_A(0.0943);3baj_A(0.0824);1u30_A(0.0939);1jxj_A(0.0972);1c8q_A(0.0988);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);3cpu_A(0.092);1xcx_A(0.0892);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive T:1 0.0723 1 1 luad:1 ENST00000370079 3 3d AMY1C D332 332 712 1b2y_A(0.0916);3ole_A(0.0951);2cpu_A(0.0931);1kb3_A(0.0944);3old_A(0.0981);4gqr_A(0.0952);1kbk_A(0.0902);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);1xd0_A(0.0851);3bay_A(0.0913);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);1xh1_A(0.0885);3ij7_A(0.0896);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);1mfu_A(0.0986);3bai_A(0.0903);1u33_A(0.0923);2qmk_A(0.0959);3bak_A(0.0943);3baj_A(0.0824);1u30_A(0.0939);1jxj_A(0.0972);1c8q_A(0.0988);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);3cpu_A(0.092);1xcx_A(0.0892);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive N:1 0.0723 1 1 lusc:1 ENST00000370079 3 3d AMY1C I327 327 713 1b2y_A(0.0916);2cpu_A(0.0931);3ole_A(0.0951);3old_A(0.0981);1kb3_A(0.0944);4gqq_A(0.097);1kbk_A(0.0902);4gqr_A(0.0952);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);3bay_A(0.0913);1xd0_A(0.0851);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);3ij7_A(0.0896);1xh1_A(0.0885);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);3bai_A(0.0903);1u33_A(0.0923);1mfu_A(0.0986);3bak_A(0.0943);2qmk_A(0.0959);3baj_A(0.0824);1u30_A(0.0939);1c8q_A(0.0988);1jxj_A(0.0972);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);1xcx_A(0.0892);3cpu_A(0.092);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive T:1 0.0723 1 1 luad:1 ENST00000370079 3 3d AMY1C D332 332 713 1b2y_A(0.0916);2cpu_A(0.0931);3ole_A(0.0951);3old_A(0.0981);1kb3_A(0.0944);4gqq_A(0.097);1kbk_A(0.0902);4gqr_A(0.0952);1u2y_A(0.0918);3olg_A(0.0908);3oli_A(0.0949);3blk_A(0.0982);1xd1_A(0.0933);1bsi_A(0.089);3bax_A(0.096);3bay_A(0.0913);1xd0_A(0.0851);3ij9_A(0.0927);3ij8_A(0.0922);1xh0_A(0.0876);3ij7_A(0.0896);1xh1_A(0.0885);1xh2_A(0.0856);1cpu_A(0.0951);3baw_A(0.094);3bai_A(0.0903);1u33_A(0.0923);1mfu_A(0.0986);3bak_A(0.0943);2qmk_A(0.0959);3baj_A(0.0824);1u30_A(0.0939);1c8q_A(0.0988);1jxj_A(0.0972);1hny_A(0.094);3blp_X(0.0964);1kbb_A(0.089);1xgz_A(0.0902);1xcx_A(0.0892);3cpu_A(0.092);1xcw_A(0.0916);1kgu_A(0.0964);1kgx_A(0.0834);1kgw_A(0.0723);2qv4_A(0.0938) Cluster-exclusive N:1 0.0723 1 1 lusc:1 ENST00000370079 3 3d C10ORF71 S93 93 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive L:1 0.0728 1 1 stad:1 ENST00000374144 3 3d C10ORF71 W95 95 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive L:1 0.0728 1 1 luad:1 ENST00000374144 3 3d C10ORF71 A96 96 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive V:3 0.0728 3 3 stad:1|ucec:1|luad:1 ENST00000374144 3 3d C10ORF71 A97 97 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive D:1 0.0728 1 1 luad:1 ENST00000374144 3 3d C10ORF71 Q123 123 718 3bg3_B(0.0728);3bg3_A(0.0737) Cluster-exclusive H:1 0.0728 1 1 luad:1 ENST00000374144 3 3d H3C13 K123 123 721 4ld9_A(0.0732) Cluster-exclusive N:1 0.0732 1 1 brca:1 ENST00000331491 1 3d H3C13 D124 124 721 4ld9_A(0.0732) Cluster-exclusive Y:1 0.0732 1 1 brca:1 ENST00000331491 1 3d H3C13 I125 125 721 4ld9_A(0.0732) Cluster-exclusive V:1 0.0732 1 1 hnsc:1 ENST00000331491 1 3d H3C13 L127 127 721 4ld9_A(0.0732) Cluster-exclusive F:1 0.0732 1 1 coadread:1 ENST00000331491 1 3d CACNA1E E1108 1108 724 3egx_A(0.0733) Cluster-exclusive D:1 0.0733 1 1 coadread:1 ENST00000367573 2 3d CACNA1E E1109 1109 724 3egx_A(0.0733) Cluster-exclusive D:1 0.0733 1 1 luad:1 ENST00000367573 2 3d CACNA1E E1110 1110 724 3egx_A(0.0733) Cluster-exclusive D:1 0.0733 1 1 luad:1 ENST00000367573 2 3d CACNA1E E1112 1112 724 3egx_A(0.0733) Cluster-exclusive K:1 0.0733 1 1 skcm:1 ENST00000367573 2 3d CACNA1E K1113 1113 724 3egx_A(0.0733) Cluster-exclusive N:1 0.0733 1 1 ucec:1 ENST00000367573 2 3d CACNA1E Q1116 1116 724 3egx_A(0.0733) Cluster-exclusive K:1 0.0733 1 1 lihc:1 ENST00000367573 2 3d PTPN11 G60 60 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot-linked V:1 0.0735 1 1 laml:1 ENST00000351677 2 3d PTPN11 D61 61 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot-linked Y:1|N:1 0.0735 2 2 laml:1|nbl:1 ENST00000351677 2 3d PTPN11 T468 468 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot-linked M:5 0.0735 5 3 coadread:1|stad:2|skcm:2 ENST00000351677 2 3d PTPN11 T507 507 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot-linked K:2 0.0735 2 2 gbm:1|nbl:1 ENST00000351677 2 3d PTPN11 Q510 510 726 4dgp_A(0.0934);4gwf_B(0.0735);4gwf_A(0.0765);4dgx_A(0.0963) Hotspot E:1|H:3|L:3 0.0735 7 4 all:1|gbm:2|laml:2|skcm:2 ENST00000351677 2 3d MGAT1 A186 186 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive E:1|V:1 0.0741 2 2 stad:1|lusc:1 ENST00000307826 4 3d MGAT1 R187 187 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive C:1|L:1 0.0741 2 2 ov:1|lihc:1 ENST00000307826 4 3d MGAT1 R190 190 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive S:1 0.0741 1 1 kirp:1 ENST00000307826 4 3d MGAT1 W276 276 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive C:1 0.0741 1 1 luad:1 ENST00000307826 4 3d MGAT1 P281 281 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive L:1 0.0741 1 1 cscc:1 ENST00000307826 4 3d MGAT1 W283 283 731 2am5_A(0.0783);2am4_A(0.0741);1foa_A(0.0786);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive R:1 0.0741 1 1 cscc:1 ENST00000307826 4 3d MGAT1 A186 186 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive E:1|V:1 0.0741 2 2 stad:1|lusc:1 ENST00000307826 4 3d MGAT1 R187 187 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive C:1|L:1 0.0741 2 2 ov:1|lihc:1 ENST00000307826 4 3d MGAT1 R190 190 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive S:1 0.0741 1 1 kirp:1 ENST00000307826 4 3d MGAT1 A192 192 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive V:1 0.0741 1 1 ucec:1 ENST00000307826 4 3d MGAT1 W276 276 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive C:1 0.0741 1 1 luad:1 ENST00000307826 4 3d MGAT1 W283 283 732 2am5_A(0.0783);2am4_A(0.0741);2apc_A(0.076);2am3_A(0.0779);1fo8_A(0.0755);1fo9_A(0.0796) Cluster-exclusive R:1 0.0741 1 1 cscc:1 ENST00000307826 4 3d UQCRFS1 E153 153 733 2bcc_E(0.0813);1bcc_E(0.0741);3bcc_E(0.0819) Cluster-exclusive K:2 0.0741 2 1 coadread:2 ENST00000304863 4 3d UQCRFS1 F265 265 733 2bcc_E(0.0813);1bcc_E(0.0741);3bcc_E(0.0819) Cluster-exclusive L:1 0.0741 1 1 ucec:1 ENST00000304863 4 3d UQCRFS1 M270 270 733 2bcc_E(0.0813);1bcc_E(0.0741);3bcc_E(0.0819) Cluster-exclusive V:1 0.0741 1 1 hnsc:1 ENST00000304863 4 3d UQCRFS1 V271 271 733 2bcc_E(0.0813);1bcc_E(0.0741);3bcc_E(0.0819) Cluster-exclusive A:1 0.0741 1 1 stad:1 ENST00000304863 4 3d UQCRFS1 I272 272 733 2bcc_E(0.0813);1bcc_E(0.0741);3bcc_E(0.0819) Cluster-exclusive T:1 0.0741 1 1 coadread:1 ENST00000304863 4 3d CDH1 R222 222 735 2o72_A(0.0744) Cluster-exclusive G:1 0.0744 1 1 stad:1 ENST00000261769 5 3d CDH1 D254 254 735 2o72_A(0.0744) Cluster-exclusive Y:4|N:2 0.0744 6 2 stad:5|esca:1 ENST00000261769 5 3d CDH1 A289 289 735 2o72_A(0.0744) Cluster-exclusive V:1 0.0744 1 1 coadread:1 ENST00000261769 5 3d CDH1 D290 290 735 2o72_A(0.0744) Cluster-exclusive G:1 0.0744 1 1 stad:1 ENST00000261769 5 3d CDH1 D291 291 735 2o72_A(0.0744) Cluster-exclusive N:1 0.0744 1 1 coadread:1 ENST00000261769 5 3d EPHB1 Y740 740 736 3zfx_E(0.0748) Cluster-exclusive H:1 0.0748 1 1 stad:1 ENST00000398015 3 3d EPHB1 H742 742 736 3zfx_E(0.0748) Cluster-exclusive N:1 0.0748 1 1 skcm:1 ENST00000398015 3 3d EPHB1 R743 743 736 3zfx_E(0.0748) Cluster-exclusive Q:1 0.0748 1 1 stad:1 ENST00000398015 3 3d EPHB1 D744 744 736 3zfx_E(0.0748) Cluster-exclusive Y:1|N:1 0.0748 2 2 cscc:1|luad:1 ENST00000398015 3 3d EPHB1 V760 760 736 3zfx_E(0.0748) Cluster-exclusive A:1 0.0748 1 1 cll:1 ENST00000398015 3 3d EPHB1 D762 762 736 3zfx_E(0.0748) Cluster-exclusive E:1|N:4 0.0748 5 4 stad:1|gbm:1|skcm:2|ucec:1 ENST00000398015 3 3d EPHB1 D806 806 736 3zfx_E(0.0748) Cluster-exclusive N:2 0.0748 2 2 coadread:1|stad:1 ENST00000398015 3 3d SMAD4 D351 351 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot A:1|G:3|H:2|Y:2 0.0749 8 6 paad:2|coadread:2|prad:1|stad:1|esca:1|luad:1 ENST00000342988 3 3d SMAD4 G352 352 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked A:1|R:1 0.0749 2 2 coadread:1|stad:1 ENST00000342988 3 3d SMAD4 I383 383 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked R:1 0.0749 1 1 stad:1 ENST00000342988 3 3d SMAD4 G384 384 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot-linked D:1 0.0749 1 1 paad:1 ENST00000342988 3 3d SMAD4 G386 386 737 1g88_B(0.0886);1dd1_B(0.0749) Hotspot A:1|S:1|C:1|D:5|V:3 0.0749 11 6 paad:1|coadread:3|prad:1|stad:2|esca:3|luad:1 ENST00000342988 3 3d CAND1 F371 371 743 4a0c_B(0.0758) Cluster-exclusive I:1 0.0758 1 1 stad:1 ENST00000545606 1 3d CAND1 Y372 372 743 4a0c_B(0.0758) Cluster-exclusive C:1 0.0758 1 1 luad:1 ENST00000545606 1 3d CAND1 S376 376 743 4a0c_B(0.0758) Cluster-exclusive P:1 0.0758 1 1 coadread:1 ENST00000545606 1 3d CAND1 A397 397 743 4a0c_B(0.0758) Cluster-exclusive T:1 0.0758 1 1 gbm:1 ENST00000545606 1 3d CAND1 L399 399 743 4a0c_B(0.0758) Cluster-exclusive R:1 0.0758 1 1 thca:1 ENST00000545606 1 3d CAND1 L401 401 743 4a0c_B(0.0758) Cluster-exclusive I:1 0.0758 1 1 hnsc:1 ENST00000545606 1 3d CAND1 T405 405 743 4a0c_B(0.0758) Cluster-exclusive S:1 0.0758 1 1 luad:1 ENST00000545606 1 3d MRPL11 A121 121 749 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive S:1 0.0764 1 1 skcm:1 ENST00000310999 7 3d MRPL11 V141 141 749 3iy9_G(0.0765);2ftc_G(0.0764) Cluster-exclusive L:1 0.0764 1 1 lihc:1 ENST00000310999 7 3d TP53 Y163 163 750 4ibv_A(0.0765) Hotspot C:27|D:2|H:4|N:4 0.0765 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 V173 173 750 4ibv_A(0.0765) Hotspot A:2|E:1|G:2|L:15|M:12 0.0765 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 750 4ibv_A(0.0765) Hotspot-linked S:1|W:2|K:1 0.0765 4 1 lihc:4 ENST00000269305 4 3d TP53 L194 194 750 4ibv_A(0.0765) Hotspot P:2|R:15|F:3|H:3 0.0765 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 C238 238 750 4ibv_A(0.0765) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0765 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 750 4ibv_A(0.0765) Hotspot S:8|D:6|T:1 0.0765 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 750 4ibv_A(0.0765) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0765 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 750 4ibv_A(0.0765) Hotspot R:1|C:8|S:5|D:9|V:2 0.0765 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 750 4ibv_A(0.0765) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0765 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 750 4ibv_A(0.0765) Hotspot-linked R:2|V:3|I:5 0.0765 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 750 4ibv_A(0.0765) Hotspot-linked I:4 0.0765 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 750 4ibv_A(0.0765) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0765 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 750 4ibv_A(0.0765) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0765 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 750 4ibv_A(0.0765) Hotspot-linked S:2|F:1|N:3 0.0765 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V274 274 750 4ibv_A(0.0765) Hotspot A:4|D:5|F:7|G:4|L:1 0.0765 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d CST6 T72 72 752 1g0y_R(0.0766);4dep_B(0.0816);1ira_Y(0.0779);4dep_E(0.085);4gaf_B(0.0846) Cluster-exclusive M:1 0.0766 1 1 lihc:1 ENST00000312134 2 3d CST6 T90 90 752 1g0y_R(0.0766);4dep_B(0.0816);1ira_Y(0.0779);4dep_E(0.085);4gaf_B(0.0846) Cluster-exclusive K:1|M:1 0.0766 2 2 coadread:1|lihc:1 ENST00000312134 2 3d CST6 M91 91 752 1g0y_R(0.0766);4dep_B(0.0816);1ira_Y(0.0779);4dep_E(0.085);4gaf_B(0.0846) Cluster-exclusive I:1 0.0766 1 1 skcm:1 ENST00000312134 2 3d CDKN2C Q43 43 755 1bu9_A(0.0769) Cluster-exclusive H:1 0.0769 1 1 coadread:1 ENST00000262662 1 3d CDKN2C D64 64 755 1bu9_A(0.0769) Cluster-exclusive N:1 0.0769 1 1 ov:1 ENST00000262662 1 3d CDKN2C K66 66 755 1bu9_A(0.0769) Cluster-exclusive E:1 0.0769 1 1 ucec:1 ENST00000262662 1 3d CDKN2C D67 67 755 1bu9_A(0.0769) Cluster-exclusive N:1 0.0769 1 1 thca:1 ENST00000262662 1 3d CDKN2C A72 72 755 1bu9_A(0.0769) Cluster-exclusive T:1 0.0769 1 1 esca:1 ENST00000262662 1 3d CDKN2C E99 99 755 1bu9_A(0.0769) Cluster-exclusive K:1 0.0769 1 1 lusc:1 ENST00000262662 1 3d PIK3R1 K459 459 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked E:1 0.0781 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 K567 567 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot E:5 0.0781 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked T:1 0.0781 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 D569 569 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked G:1 0.0781 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked P:1 0.0781 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked R:1 0.0781 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 L573 573 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked P:3 0.0781 3 3 gbm:1|ucec:1|lymbc:1 ENST00000274335 5 3d PIK3R1 R574 574 761 3hiz_B(0.0839);3hhm_B(0.0916);4waf_B(0.0781) Hotspot-linked T:1|I:2 0.0781 3 3 coadread:1|ucec:1|cesc:1 ENST00000274335 5 3d RXRA R426 426 765 3nsp_B(0.098);1uhl_A(0.0787);1xdk_A(0.0969) Hotspot-linked H:1 0.0787 1 1 hnsc:1 ENST00000481739 1 3d RXRA S427 427 765 3nsp_B(0.098);1uhl_A(0.0787);1xdk_A(0.0969) Hotspot F:11|Y:3 0.0787 14 3 paad:1|blca:12|lihc:1 ENST00000481739 1 3d RXRA G429 429 765 3nsp_B(0.098);1uhl_A(0.0787);1xdk_A(0.0969) Hotspot-linked V:1 0.0787 1 1 luad:1 ENST00000481739 1 3d RXRA L430 430 765 3nsp_B(0.098);1uhl_A(0.0787);1xdk_A(0.0969) Hotspot-linked H:1 0.0787 1 1 lihc:1 ENST00000481739 1 3d CTSL G145 145 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive C:1 0.0789 1 1 stad:1 ENST00000340342 6 3d CTSL A146 146 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive S:1 0.0789 1 1 ov:1 ENST00000340342 6 3d CTSL Q150 150 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive H:1 0.0789 1 1 coadread:1 ENST00000340342 6 3d CTSL V242 242 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive M:2 0.0789 2 2 brca:1|stad:1 ENST00000340342 6 3d CTSL P244 244 767 2xu4_A(0.0849);2yj9_A(0.0893);2xu3_A(0.0838);2yj8_A(0.0789);2yjb_A(0.085);2yj2_A(0.0824);2yjc_A(0.0884) Cluster-exclusive S:1 0.0789 1 1 kirp:1 ENST00000340342 6 3d PIK3R1 N564 564 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot D:6 0.0791 6 4 coadread:2|skcm:1|ucec:1|lgg:2 ENST00000274335 5 3d PIK3R1 S565 565 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot-linked R:1|N:1 0.0791 2 2 coadread:1|ov:1 ENST00000274335 5 3d PIK3R1 K567 567 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot E:5 0.0791 5 4 stad:1|esca:1|ucec:2|lymbc:1 ENST00000274335 5 3d PIK3R1 P568 568 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot-linked T:1 0.0791 1 1 ucec:1 ENST00000274335 5 3d PIK3R1 D569 569 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot-linked G:1 0.0791 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 L570 570 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot-linked P:1 0.0791 1 1 gbm:1 ENST00000274335 5 3d PIK3R1 Q572 572 769 3hiz_B(0.083);3hhm_B(0.091);4waf_B(0.0791) Hotspot-linked R:1 0.0791 1 1 ucec:1 ENST00000274335 5 3d STK24 I136 136 771 3ckx_A(0.0796) Cluster-exclusive M:1 0.0796 1 1 ucec:1 ENST00000376547 3 3d STK24 E139 139 771 3ckx_A(0.0796) Cluster-exclusive K:1 0.0796 1 1 ucec:1 ENST00000376547 3 3d STK24 I140 140 771 3ckx_A(0.0796) Cluster-exclusive M:1 0.0796 1 1 gbm:1 ENST00000376547 3 3d STK24 V170 170 771 3ckx_A(0.0796) Cluster-exclusive M:1 0.0796 1 1 cscc:1 ENST00000376547 3 3d RHOA L22 22 776 4f38_A(0.0805) Hotspot-linked P:1|R:1 0.0805 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA I23 23 776 4f38_A(0.0805) Hotspot-linked R:1 0.0805 1 1 lymbc:1 ENST00000418115 1 3d RHOA T37 37 776 4f38_A(0.0805) Hotspot-linked S:1|I:1 0.0805 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 776 4f38_A(0.0805) Hotspot-linked C:1 0.0805 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 776 4f38_A(0.0805) Hotspot Q:6|K:1 0.0805 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA N41 41 776 4f38_A(0.0805) Hotspot-linked K:1 0.0805 1 1 stad:1 ENST00000418115 1 3d RHOA Y42 42 776 4f38_A(0.0805) Hotspot C:7|S:2|F:1|I:1 0.0805 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA D59 59 776 4f38_A(0.0805) Hotspot-linked G:1|Y:1|N:1 0.0805 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d PRPF31 R288 288 778 3siu_B(0.0964);3siv_K(0.0894);3siv_H(0.0805);2ozb_E(0.0858);2ozb_B(0.0988) Cluster-exclusive Q:1|L:1 0.0805 2 2 cll:1|cesc:1 ENST00000321030 4 3d PRPF31 R289 289 778 3siu_B(0.0964);3siv_K(0.0894);3siv_H(0.0805);2ozb_E(0.0858);2ozb_B(0.0988) Cluster-exclusive Q:1|W:1 0.0805 2 2 stad:1|lgg:1 ENST00000321030 4 3d PRPF31 R293 293 778 3siu_B(0.0964);3siv_K(0.0894);3siv_H(0.0805);2ozb_E(0.0858);2ozb_B(0.0988) Cluster-exclusive W:1 0.0805 1 1 esca:1 ENST00000321030 4 3d PRPF31 V295 295 778 3siu_B(0.0964);3siv_K(0.0894);3siv_H(0.0805);2ozb_E(0.0858);2ozb_B(0.0988) Cluster-exclusive M:1 0.0805 1 1 coadread:1 ENST00000321030 4 3d PRPF31 A297 297 778 3siu_B(0.0964);3siv_K(0.0894);3siv_H(0.0805);2ozb_E(0.0858);2ozb_B(0.0988) Cluster-exclusive T:1 0.0805 1 1 coadread:1 ENST00000321030 4 3d WDR75 I520 520 779 2qnk_A(0.0805) Cluster-exclusive T:1 0.0805 1 1 brca:1 ENST00000314761 4 3d WDR75 V521 521 779 2qnk_A(0.0805) Cluster-exclusive I:1 0.0805 1 1 hnsc:1 ENST00000314761 4 3d WDR75 T522 522 779 2qnk_A(0.0805) Cluster-exclusive I:1 0.0805 1 1 ucec:1 ENST00000314761 4 3d WDR75 A539 539 779 2qnk_A(0.0805) Cluster-exclusive V:1 0.0805 1 1 lihc:1 ENST00000314761 4 3d WDR75 L565 565 779 2qnk_A(0.0805) Cluster-exclusive I:1 0.0805 1 1 ucec:1 ENST00000314761 4 3d TP53 C176 176 781 4ibv_A(0.0809) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0809 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 781 4ibv_A(0.0809) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0809 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 C238 238 781 4ibv_A(0.0809) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0809 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 781 4ibv_A(0.0809) Hotspot S:8|D:6|T:1 0.0809 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S241 241 781 4ibv_A(0.0809) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0809 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 781 4ibv_A(0.0809) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0809 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 781 4ibv_A(0.0809) Hotspot-linked I:1 0.0809 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 781 4ibv_A(0.0809) Hotspot R:1|C:8|S:5|D:9|V:2 0.0809 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 781 4ibv_A(0.0809) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0809 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 781 4ibv_A(0.0809) Hotspot-linked R:2|V:3|I:5 0.0809 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 781 4ibv_A(0.0809) Hotspot-linked I:4 0.0809 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 781 4ibv_A(0.0809) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0809 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d LCMT1 L97 97 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive H:1 0.0813 1 1 coadread:1 ENST00000399069 3 3d LCMT1 G98 98 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive V:1 0.0813 1 1 luad:1 ENST00000399069 3 3d LCMT1 A99 99 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive T:1 0.0813 1 1 paad:1 ENST00000399069 3 3d LCMT1 L172 172 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive F:1 0.0813 1 1 cesc:1 ENST00000399069 3 3d LCMT1 E198 198 784 3o7w_A(0.0813);3iei_C(0.0936);3iei_D(0.0947);3iei_A(0.0962);3iei_B(0.0943);3iei_G(0.0959);3iei_H(0.0949);3iei_E(0.0965) Cluster-exclusive Q:1 0.0813 1 1 luad:1 ENST00000399069 3 3d TP53 C135 135 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot R:3|S:2|F:9|W:2|G:1|Y:9 0.0814 26 12 acc:1|brca:5|paad:1|coadread:3|prad:2|stad:2|esca:5|blca:1|ov:2|lusc:1|lgg:1|luad:2 ENST00000269305 4 3d TP53 L137 137 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot-linked Q:1 0.0814 1 1 hnsc:1 ENST00000269305 4 3d TP53 A138 138 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot-linked P:1|T:1|V:4 0.0814 6 5 coadread:2|gbm:1|hnsc:1|ov:1|cscc:1 ENST00000269305 4 3d TP53 L194 194 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot P:2|R:15|F:3|H:3 0.0814 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 Y236 236 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot C:16|D:2|N:2 0.0814 20 11 brca:1|paad:1|coadread:1|prad:1|stad:1|hnsc:6|ov:2|lusc:1|lgg:3|luad:2|cscc:1 ENST00000269305 4 3d TP53 M237 237 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot V:3|I:17|K:4 0.0814 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0814 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 V272 272 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot E:1|G:4|K:1|L:1|M:17 0.0814 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 V274 274 786 2h1l_O(0.0874);2h1l_U(0.0983);2h1l_T(0.0882);2h1l_R(0.0814);2h1l_M(0.0919) Hotspot A:4|D:5|F:7|G:4|L:1 0.0814 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d HSD17B10 G10 10 787 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive D:1 0.0814 1 1 skcm:1 ENST00000168216 6 3d HSD17B10 L11 11 787 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive M:1 0.0814 1 1 luad:1 ENST00000168216 6 3d HSD17B10 V12 12 787 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive A:1 0.0814 1 1 coadread:1 ENST00000168216 6 3d HSD17B10 G34 34 787 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive E:1 0.0814 1 1 brca:1 ENST00000168216 6 3d HSD17B10 G10 10 788 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive D:1 0.0814 1 1 skcm:1 ENST00000168216 6 3d HSD17B10 L11 11 788 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive M:1 0.0814 1 1 luad:1 ENST00000168216 6 3d HSD17B10 V12 12 788 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive A:1 0.0814 1 1 coadread:1 ENST00000168216 6 3d HSD17B10 A13 13 788 1e3w_D(0.085);1e6w_D(0.0814) Cluster-exclusive T:1 0.0814 1 1 ucec:1 ENST00000168216 6 3d BRAF G596 596 793 4pp7_B(0.0821) Hotspot R:2|S:1|D:1|V:1 0.0821 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 793 4pp7_B(0.0821) Hotspot Q:2|R:1|S:1 0.0821 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 793 4pp7_B(0.0821) Hotspot R:4|E:509|K:32 0.0821 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 793 4pp7_B(0.0821) Hotspot T:1|E:12|N:2 0.0821 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d BRAF W604 604 793 4pp7_B(0.0821) Hotspot-linked L:1 0.0821 1 1 luad:1 ENST00000288602 6 3d CLTCL1 V478 478 794 1agq_B(0.0876);1agq_C(0.0821);1agq_D(0.0941);3fub_D(0.0982) Cluster-exclusive A:1 0.0821 1 1 lihc:1 ENST00000427926 1 3d CLTCL1 L480 480 794 1agq_B(0.0876);1agq_C(0.0821);1agq_D(0.0941);3fub_D(0.0982) Cluster-exclusive F:1 0.0821 1 1 prad:1 ENST00000427926 1 3d CLTCL1 R481 481 794 1agq_B(0.0876);1agq_C(0.0821);1agq_D(0.0941);3fub_D(0.0982) Cluster-exclusive P:1|W:2 0.0821 3 3 paad:1|coadread:1|lihc:1 ENST00000427926 1 3d SPOP F102 102 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot C:2|V:2|L:1 0.0826 5 1 prad:5 ENST00000347630 2 3d SPOP K103 103 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot-linked N:1 0.0826 1 1 ucec:1 ENST00000347630 2 3d SPOP M117 117 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot-linked V:4 0.0826 4 3 ucs:1|ucec:2|cesc:1 ENST00000347630 2 3d SPOP S119 119 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot-linked R:1|N:1 0.0826 2 2 mmyl:1|prad:1 ENST00000347630 2 3d SPOP R121 121 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot-linked Q:3 0.0826 3 2 ucec:2|luad:1 ENST00000347630 2 3d SPOP F133 133 799 3hqm_B(0.0908);3ivq_B(0.0826);4o1v_A(0.0905);3ivq_A(0.0877);3hqm_A(0.088);3hql_B(0.0908);3hql_A(0.0897);3hsv_A(0.0858);3ivv_A(0.0914) Hotspot S:3|C:4|V:4|I:2|L:9 0.0826 22 1 prad:22 ENST00000347630 2 3d MOB1B A111 111 805 1r3b_A(0.0834) Cluster-exclusive T:1 0.0834 1 1 coadread:1 ENST00000309395 2 3d MOB1B Y114 114 805 1r3b_A(0.0834) Cluster-exclusive C:1 0.0834 1 1 brca:1 ENST00000309395 2 3d MOB1B I115 115 805 1r3b_A(0.0834) Cluster-exclusive T:1 0.0834 1 1 skcm:1 ENST00000309395 2 3d MOB1B H161 161 805 1r3b_A(0.0834) Cluster-exclusive D:1 0.0834 1 1 hnsc:1 ENST00000309395 2 3d CACNA1B R1254 1254 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive H:1 0.0839 1 1 ucec:1 ENST00000371372 1 3d CACNA1B V1255 1255 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive I:1 0.0839 1 1 dlbc:1 ENST00000371372 1 3d CACNA1B K1260 1260 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive N:1 0.0839 1 1 ucec:1 ENST00000371372 1 3d CACNA1B L1268 1268 808 1vkl_A(0.0839);1c4g_A(0.0864);1lxt_A(0.0956) Cluster-exclusive V:1 0.0839 1 1 nbl:1 ENST00000371372 1 3d SMC1A R635 635 810 2wd5_A(0.0842) Cluster-exclusive H:1 0.0842 1 1 ucec:1 ENST00000322213 4 3d SMC1A K637 637 810 2wd5_A(0.0842) Cluster-exclusive R:1 0.0842 1 1 ucec:1 ENST00000322213 4 3d SMC1A T638 638 810 2wd5_A(0.0842) Cluster-exclusive K:1 0.0842 1 1 gbm:1 ENST00000322213 4 3d SMC1A F646 646 810 2wd5_A(0.0842) Cluster-exclusive L:1 0.0842 1 1 lihc:1 ENST00000322213 4 3d SMC1A Q647 647 810 2wd5_A(0.0842) Cluster-exclusive H:1 0.0842 1 1 coadread:1 ENST00000322213 4 3d GRB2 F95 95 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive V:1 0.0844 1 1 brca:1 ENST00000316804 5 3d GRB2 R112 112 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive Q:1 0.0844 1 1 skcm:1 ENST00000316804 5 3d GRB2 G116 116 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive R:1|W:1 0.0844 2 2 coadread:1|lihc:1 ENST00000316804 5 3d GRB2 K117 117 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive R:1 0.0844 1 1 ucec:1 ENST00000316804 5 3d GRB2 Y118 118 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive S:1 0.0844 1 1 mmyl:1 ENST00000316804 5 3d GRB2 S127 127 811 3in7_A(0.0993);3mxc_A(0.0983);4p9v_A(0.0875);1bm2_A(0.0941);1bmb_A(0.0844);1zfp_E(0.0923);3n7y_A(0.0963) Cluster-exclusive Y:1 0.0844 1 1 coadread:1 ENST00000316804 5 3d NCF1 F117 117 813 1gd5_A(0.0845) Cluster-exclusive V:1 0.0845 1 1 stad:1 ENST00000289473 4 3d NCF1 F118 118 813 1gd5_A(0.0845) Cluster-exclusive L:1 0.0845 1 1 brca:1 ENST00000289473 4 3d NCF1 V120 120 813 1gd5_A(0.0845) Cluster-exclusive M:1 0.0845 1 1 cscc:1 ENST00000289473 4 3d NCF1 R121 121 813 1gd5_A(0.0845) Cluster-exclusive C:3 0.0845 3 3 coadread:1|stad:1|hnsc:1 ENST00000289473 4 3d CREBBP S1778 1778 814 3p57_P(0.0846) Cluster-exclusive L:1 0.0846 1 1 skcm:1 ENST00000262367 5 3d CREBBP A1782 1782 814 3p57_P(0.0846) Cluster-exclusive T:2 0.0846 2 2 coadread:1|ucec:1 ENST00000262367 5 3d CREBBP R1786 1786 814 3p57_P(0.0846) Cluster-exclusive C:1 0.0846 1 1 coadread:1 ENST00000262367 5 3d CREBBP C1795 1795 814 3p57_P(0.0846) Cluster-exclusive R:1 0.0846 1 1 pias:1 ENST00000262367 5 3d BRAF G466 466 817 4g9c_A(0.085) Hotspot A:1|E:6|V:10 0.085 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 817 4g9c_A(0.085) Hotspot-linked L:2 0.085 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 817 4g9c_A(0.085) Hotspot A:9|R:3|S:1|E:2|V:6 0.085 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF F595 595 817 4g9c_A(0.085) Hotspot-linked L:1 0.085 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 817 4g9c_A(0.085) Hotspot R:2|S:1|D:1|V:1 0.085 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 817 4g9c_A(0.085) Hotspot Q:2|R:1|S:1 0.085 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d IL13RA2 P35 35 821 3lb6_C(0.0853) Cluster-exclusive L:1 0.0853 1 1 luad:1 ENST00000243213 1 3d IL13RA2 H106 106 821 3lb6_C(0.0853) Cluster-exclusive R:1 0.0853 1 1 coadread:1 ENST00000243213 1 3d IL13RA2 S122 122 821 3lb6_C(0.0853) Cluster-exclusive F:1 0.0853 1 1 skcm:1 ENST00000243213 1 3d IL13RA2 W123 123 821 3lb6_C(0.0853) Cluster-exclusive L:1 0.0853 1 1 luad:1 ENST00000243213 1 3d IL13RA2 A124 124 821 3lb6_C(0.0853) Cluster-exclusive T:1 0.0853 1 1 gbm:1 ENST00000243213 1 3d CFL1 V14 14 822 Cluster-exclusive G:1 0.0854 1 1 brca:1 ENST00000308162 5 3d CFL1 F15 15 822 Cluster-exclusive L:1 0.0854 1 1 stad:1 ENST00000308162 5 3d CFL1 M18 18 822 Cluster-exclusive L:2 0.0854 2 2 hnsc:1|lihc:1 ENST00000308162 5 3d CFL1 K34 34 822 Cluster-exclusive R:1 0.0854 1 1 stad:1 ENST00000308162 5 3d CFL1 V36 36 822 Cluster-exclusive M:1 0.0854 1 1 stad:1 ENST00000308162 5 3d CFL1 D86 86 822 Cluster-exclusive G:1 0.0854 1 1 cll:1 ENST00000308162 5 3d KIT V559 559 824 4hvs_A(0.0854) Cluster-exclusive A:3 0.0854 3 1 skcm:3 ENST00000288135 5 3d KIT L576 576 824 4hvs_A(0.0854) Cluster-exclusive P:2 0.0854 2 1 skcm:2 ENST00000288135 5 3d HRAS A11 11 829 821p_A(0.0861) Hotspot-linked D:1 0.0861 1 1 hnsc:1 ENST00000451590 1 3d HRAS G13 13 829 821p_A(0.0861) Hotspot R:11|C:2|S:1|D:2|V:9 0.0861 25 7 brca:1|blca:4|hnsc:13|skcm:2|lusc:3|luad:1|cscc:1 ENST00000451590 1 3d HRAS T58 58 829 821p_A(0.0861) Hotspot-linked I:1 0.0861 1 1 cscc:1 ENST00000451590 1 3d HRAS A59 59 829 821p_A(0.0861) Hotspot-linked T:1 0.0861 1 1 ucec:1 ENST00000451590 1 3d HRAS G60 60 829 821p_A(0.0861) Hotspot-linked S:1 0.0861 1 1 coadread:1 ENST00000451590 1 3d HRAS Q61 61 829 821p_A(0.0861) Hotspot R:19|H:2|K:10|L:9 0.0861 40 9 brca:1|prad:2|thca:14|blca:8|hnsc:6|skcm:3|lusc:2|cscc:3|luad:1 ENST00000451590 1 3d TP53 C238 238 833 2h1l_R(0.0866) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0866 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 833 2h1l_R(0.0866) Hotspot S:8|D:6|T:1 0.0866 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 833 2h1l_R(0.0866) Hotspot-linked R:1|G:2 0.0866 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 833 2h1l_R(0.0866) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0866 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 833 2h1l_R(0.0866) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0866 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 833 2h1l_R(0.0866) Hotspot-linked I:1 0.0866 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 833 2h1l_R(0.0866) Hotspot R:1|C:8|S:5|D:9|V:2 0.0866 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 833 2h1l_R(0.0866) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0866 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 R249 249 833 2h1l_R(0.0866) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0866 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 833 2h1l_R(0.0866) Hotspot-linked S:2|F:1|N:3 0.0866 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V272 272 833 2h1l_R(0.0866) Hotspot E:1|G:4|K:1|L:1|M:17 0.0866 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 R273 273 833 2h1l_R(0.0866) Hotspot P:4|C:119|S:5|H:103|L:22 0.0866 253 24 acc:1|brca:20|paad:12|mmyl:1|coadread:30|cll:3|esca:14|ucs:4|blca:3|hnsc:19|laml:1|ov:25|hgg:4|lihc:3|lusc:6|lgg:47|lusm:3|prad:4|stad:19|gbm:7|mbl:1|skcm:1|ucec:9|luad:16 ENST00000269305 4 3d TP53 V274 274 833 2h1l_R(0.0866) Hotspot A:4|D:5|F:7|G:4|L:1 0.0866 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d TP53 C275 275 833 2h1l_R(0.0866) Hotspot R:1|S:4|F:10|Y:15 0.0866 30 16 acc:1|mmyl:1|brca:1|paad:1|coadread:3|cll:1|esca:1|blca:1|hnsc:3|ov:4|lihc:2|lgg:2|kich:1|gbm:2|skcm:2|luad:4 ENST00000269305 4 3d MDFIC G108 108 835 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive R:1|E:1 0.0866 2 2 coadread:1|luad:1 ENST00000393486 1 3d MDFIC G112 112 835 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive R:2 0.0866 2 2 blca:1|ov:1 ENST00000393486 1 3d MDFIC S128 128 835 3qe9_Y(0.093);3qe9_Z(0.0866);3qeb_Z(0.0895);3qea_Z(0.0867) Cluster-exclusive F:1 0.0866 1 1 skcm:1 ENST00000393486 1 3d SERPINB3 N8 8 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive K:1 0.0869 1 1 luad:1 ENST00000283752 5 3d SERPINB3 T9 9 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive N:1 0.0869 1 1 luad:1 ENST00000283752 5 3d SERPINB3 K10 10 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive N:1 0.0869 1 1 luad:1 ENST00000283752 5 3d SERPINB3 F11 11 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive L:1 0.0869 1 1 coadread:1 ENST00000283752 5 3d SERPINB3 P31 31 837 2zv6_C(0.0869);2zv6_A(0.099) Cluster-exclusive L:1 0.0869 1 1 luad:1 ENST00000283752 5 3d PTPN11 E69 69 843 4fr4_D(0.0945);4fr4_C(0.0894);4fr4_E(0.0879);4fr4_B(0.0956);4fr4_A(0.0928) Hotspot-linked D:1|K:3 0.0879 4 3 coadread:2|gbm:1|pias:1 ENST00000351677 2 3d PTPN11 F71 71 843 4fr4_D(0.0945);4fr4_C(0.0894);4fr4_E(0.0879);4fr4_B(0.0956);4fr4_A(0.0928) Hotspot-linked L:3 0.0879 3 3 laml:1|skcm:1|lgg:1 ENST00000351677 2 3d PTPN11 A72 72 843 4fr4_D(0.0945);4fr4_C(0.0894);4fr4_E(0.0879);4fr4_B(0.0956);4fr4_A(0.0928) Hotspot T:3|D:2|V:2 0.0879 7 4 cll:2|laml:1|nbl:2|lgg:2 ENST00000351677 2 3d PTPN11 M82 82 843 4fr4_D(0.0945);4fr4_C(0.0894);4fr4_E(0.0879);4fr4_B(0.0956);4fr4_A(0.0928) Hotspot-linked V:1 0.0879 1 1 luad:1 ENST00000351677 2 3d LHX6 S141 141 844 1zw6_A(0.0929);621p_A(0.0987);4epw_A(0.0946);1gnq_A(0.1);4dsu_A(0.0984);3gft_B(0.0911);1bkd_R(0.0995);1nvu_Q(0.098);4lyj_A(0.0879);1nvv_Q(0.0998);1nvx_Q(0.0938);1lf5_A(0.0897);1nvv_R(0.0957);1xcm_A(0.0965);4epy_A(0.0966);1xd2_B(0.0948) Cluster-exclusive N:1 0.0879 1 1 coadread:1 ENST00000373755 2 3d LHX6 D142 142 844 1zw6_A(0.0929);621p_A(0.0987);4epw_A(0.0946);1gnq_A(0.1);4dsu_A(0.0984);3gft_B(0.0911);1bkd_R(0.0995);1nvu_Q(0.098);4lyj_A(0.0879);1nvv_Q(0.0998);1nvx_Q(0.0938);1lf5_A(0.0897);1nvv_R(0.0957);1xcm_A(0.0965);4epy_A(0.0966);1xd2_B(0.0948) Cluster-exclusive Y:1|N:1 0.0879 2 2 acc:1|skcm:1 ENST00000373755 2 3d LHX6 R145 145 844 1zw6_A(0.0929);621p_A(0.0987);4epw_A(0.0946);1gnq_A(0.1);4dsu_A(0.0984);3gft_B(0.0911);1bkd_R(0.0995);1nvu_Q(0.098);4lyj_A(0.0879);1nvv_Q(0.0998);1nvx_Q(0.0938);1lf5_A(0.0897);1nvv_R(0.0957);1xcm_A(0.0965);4epy_A(0.0966);1xd2_B(0.0948) Cluster-exclusive W:2 0.0879 2 2 coadread:1|gbm:1 ENST00000373755 2 3d LHX6 R146 146 844 1zw6_A(0.0929);621p_A(0.0987);4epw_A(0.0946);1gnq_A(0.1);4dsu_A(0.0984);3gft_B(0.0911);1bkd_R(0.0995);1nvu_Q(0.098);4lyj_A(0.0879);1nvv_Q(0.0998);1nvx_Q(0.0938);1lf5_A(0.0897);1nvv_R(0.0957);1xcm_A(0.0965);4epy_A(0.0966);1xd2_B(0.0948) Cluster-exclusive K:1 0.0879 1 1 cscc:1 ENST00000373755 2 3d RHOA L22 22 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot-linked P:1|R:1 0.0881 2 2 stad:1|blca:1 ENST00000418115 1 3d RHOA F39 39 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot-linked C:1 0.0881 1 1 stad:1 ENST00000418115 1 3d RHOA E40 40 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot Q:6|K:1 0.0881 7 3 brca:1|stad:1|hnsc:5 ENST00000418115 1 3d RHOA Y42 42 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot C:7|S:2|F:1|I:1 0.0881 11 3 stad:9|hnsc:1|lymbc:1 ENST00000418115 1 3d RHOA L57 57 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot-linked V:4 0.0881 4 1 stad:4 ENST00000418115 1 3d RHOA D59 59 845 2gcn_A(0.0881);2gco_A(0.0888) Hotspot-linked G:1|Y:1|N:1 0.0881 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d PPP2R1A A136 136 847 2ie4_A(0.0883) Cluster-exclusive T:1 0.0883 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A W140 140 847 2ie4_A(0.0883) Cluster-exclusive C:1 0.0883 1 1 luad:1 ENST00000322088 6 3d PPP2R1A S143 143 847 2ie4_A(0.0883) Hotspot-linked F:1 0.0883 1 1 skcm:1 ENST00000322088 6 3d PPP2R1A R144 144 847 2ie4_A(0.0883) Hotspot-linked C:1|H:1 0.0883 2 2 ucec:1|lusc:1 ENST00000322088 6 3d PPP2R1A T145 145 847 2ie4_A(0.0883) Hotspot-linked P:1 0.0883 1 1 ov:1 ENST00000322088 6 3d PPP2R1A S146 146 847 2ie4_A(0.0883) Hotspot-linked L:3 0.0883 3 3 ucs:1|skcm:1|luad:1 ENST00000322088 6 3d RBBP7 H315 315 850 2xu7_B(0.0885) Cluster-exclusive Y:1 0.0885 1 1 skcm:1 ENST00000380087 2 3d RBBP7 G336 336 850 2xu7_B(0.0885) Cluster-exclusive D:1 0.0885 1 1 stad:1 ENST00000380087 2 3d RBBP7 R339 339 850 2xu7_B(0.0885) Cluster-exclusive S:1 0.0885 1 1 coadread:1 ENST00000380087 2 3d RBBP7 R340 340 850 2xu7_B(0.0885) Cluster-exclusive C:1|H:2 0.0885 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 850 2xu7_B(0.0885) Cluster-exclusive T:1|H:1 0.0885 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d RBBP7 H369 369 850 2xu7_B(0.0885) Cluster-exclusive L:1 0.0885 1 1 blca:1 ENST00000380087 2 3d BRAF G464 464 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot-linked V:2 0.0887 2 2 lusc:1|luad:1 ENST00000288602 6 3d BRAF G466 466 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot A:1|E:6|V:10 0.0887 17 6 mmyl:4|coadread:1|hnsc:1|skcm:3|lusc:1|luad:7 ENST00000288602 6 3d BRAF S467 467 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot-linked L:2 0.0887 2 1 skcm:2 ENST00000288602 6 3d BRAF G469 469 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot A:9|R:3|S:1|E:2|V:6 0.0887 21 8 mmyl:3|coadread:1|prad:2|blca:1|skcm:4|lusc:1|luad:8|cscc:1 ENST00000288602 6 3d BRAF V471 471 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot-linked I:1 0.0887 1 1 paad:1 ENST00000288602 6 3d BRAF L485 485 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot-linked S:1|Y:1 0.0887 2 2 skcm:1|luad:1 ENST00000288602 6 3d BRAF L597 597 852 4jvg_A(0.0944);4g9c_B(0.0959);4ksq_A(0.0898);3q96_A(0.0887);4g9r_B(0.0935);1uwh_A(0.0947);4dbn_A(0.0938);3idp_A(0.0978);3ii5_B(0.0926);3ii5_A(0.0909);1uwj_A(0.0979);1uwh_B(0.0949);1uwj_B(0.0955) Hotspot Q:2|R:1|S:1 0.0887 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d SIRT3 F192 192 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive L:1 0.0888 1 1 hnsc:1 ENST00000382743 4 3d SIRT3 T255 255 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive A:1 0.0888 1 1 lihc:1 ENST00000382743 4 3d SIRT3 V286 286 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive I:1 0.0888 1 1 ucec:1 ENST00000382743 4 3d SIRT3 V287 287 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive L:1 0.0888 1 1 luad:1 ENST00000382743 4 3d SIRT3 K288 288 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive E:1 0.0888 1 1 luad:1 ENST00000382743 4 3d SIRT3 I291 291 853 4bn5_L(0.0975);4fvt_A(0.0899);4bn5_K(0.0992);3gls_D(0.0968);3gls_F(0.0888);4hd8_A(0.0943);4jt9_A(0.0965);3glu_A(0.0957);4jt8_A(0.0941) Cluster-exclusive S:1 0.0888 1 1 coadread:1 ENST00000382743 4 3d PPP2R1A R221 221 856 2pf4_B(0.0984);2pf4_A(0.0981);2iae_A(0.0954);2pf4_C(0.0976);1b3u_B(0.0892);4i5n_A(0.0985);4i5n_D(0.0973);1b3u_A(0.0999);3k7w_A(0.099) Hotspot-linked W:2 0.0892 2 2 stad:1|ucec:1 ENST00000322088 6 3d PPP2R1A S256 256 856 2pf4_B(0.0984);2pf4_A(0.0981);2iae_A(0.0954);2pf4_C(0.0976);1b3u_B(0.0892);4i5n_A(0.0985);4i5n_D(0.0973);1b3u_A(0.0999);3k7w_A(0.099) Cluster-exclusive F:4|Y:2 0.0892 6 2 ucs:2|ucec:4 ENST00000322088 6 3d PPP2R1A W257 257 856 2pf4_B(0.0984);2pf4_A(0.0981);2iae_A(0.0954);2pf4_C(0.0976);1b3u_B(0.0892);4i5n_A(0.0985);4i5n_D(0.0973);1b3u_A(0.0999);3k7w_A(0.099) Cluster-exclusive C:1 0.0892 1 1 ov:1 ENST00000322088 6 3d PPP2R1A R258 258 856 2pf4_B(0.0984);2pf4_A(0.0981);2iae_A(0.0954);2pf4_C(0.0976);1b3u_B(0.0892);4i5n_A(0.0985);4i5n_D(0.0973);1b3u_A(0.0999);3k7w_A(0.099) Hotspot-linked C:1|H:3 0.0892 4 3 coadread:1|ucec:2|luad:1 ENST00000322088 6 3d PPP2R1A R260 260 856 2pf4_B(0.0984);2pf4_A(0.0981);2iae_A(0.0954);2pf4_C(0.0976);1b3u_B(0.0892);4i5n_A(0.0985);4i5n_D(0.0973);1b3u_A(0.0999);3k7w_A(0.099) Cluster-exclusive C:1|G:1 0.0892 2 2 ov:1|lihc:1 ENST00000322088 6 3d TP53 Y163 163 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot C:27|D:2|H:4|N:4 0.0893 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 V173 173 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot A:2|E:1|G:2|L:15|M:12 0.0893 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot-linked S:1|W:2|K:1 0.0893 4 1 lihc:4 ENST00000269305 4 3d TP53 L194 194 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot P:2|R:15|F:3|H:3 0.0893 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 C238 238 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0893 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot-linked R:1|G:2 0.0893 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0893 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot R:1|C:8|S:5|D:9|V:2 0.0893 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0893 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot-linked R:2|V:3|I:5 0.0893 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot-linked I:4 0.0893 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0893 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0893 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot-linked S:2|F:1|N:3 0.0893 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d TP53 V274 274 857 2j21_B(0.091);2j21_A(0.098);2x0u_A(0.0933);2x0u_B(0.0985);2x0w_A(0.0982);3zme_A(0.0937);3zme_B(0.0901);4agn_B(0.0942);4ago_A(0.0893);4agn_A(0.0913);4agm_B(0.0993);4agm_A(0.0956);4agq_B(0.0976);4agq_A(0.095);4agp_B(0.0901);4agp_A(0.0944);4ago_B(0.0961) Hotspot A:4|D:5|F:7|G:4|L:1 0.0893 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d SETBP1 K939 939 858 3mrr_A(0.0916);2x4r_A(0.0992);3nfn_A(0.0985);3vxp_A(0.0953);3vxn_A(0.1);3mrf_A(0.0958);3mri_A(0.0908);2c7u_A(0.0924);3mrd_A(0.099);3mre_A(0.0982);4f7p_A(0.0985);3vxu_A(0.0894);1qsf_A(0.0946);1hhh_A(0.0921) Cluster-exclusive M:1|N:1 0.0894 2 2 coadread:1|kirp:1 ENST00000282030 5 3d SETBP1 R942 942 858 3mrr_A(0.0916);2x4r_A(0.0992);3nfn_A(0.0985);3vxp_A(0.0953);3vxn_A(0.1);3mrf_A(0.0958);3mri_A(0.0908);2c7u_A(0.0924);3mrd_A(0.099);3mre_A(0.0982);4f7p_A(0.0985);3vxu_A(0.0894);1qsf_A(0.0946);1hhh_A(0.0921) Cluster-exclusive Q:1|W:1 0.0894 2 2 coadread:1|skcm:1 ENST00000282030 5 3d SETBP1 S944 944 858 3mrr_A(0.0916);2x4r_A(0.0992);3nfn_A(0.0985);3vxp_A(0.0953);3vxn_A(0.1);3mrf_A(0.0958);3mri_A(0.0908);2c7u_A(0.0924);3mrd_A(0.099);3mre_A(0.0982);4f7p_A(0.0985);3vxu_A(0.0894);1qsf_A(0.0946);1hhh_A(0.0921) Cluster-exclusive R:1|N:1 0.0894 2 2 stad:1|skcm:1 ENST00000282030 5 3d IQUB V135 135 859 2daf_A(0.0896) Cluster-exclusive F:1|L:1 0.0896 2 2 brca:1|lusc:1 ENST00000324698 6 3d IQUB V136 136 859 2daf_A(0.0896) Cluster-exclusive L:2 0.0896 2 2 skcm:1|luad:1 ENST00000324698 6 3d IQUB G141 141 859 2daf_A(0.0896) Cluster-exclusive A:1 0.0896 1 1 hnsc:1 ENST00000324698 6 3d IQUB E143 143 859 2daf_A(0.0896) Cluster-exclusive K:2 0.0896 2 2 skcm:1|cscc:1 ENST00000324698 6 3d IQUB E201 201 859 2daf_A(0.0896) Cluster-exclusive K:1 0.0896 1 1 cscc:1 ENST00000324698 6 3d CREBBP S1778 1778 860 3io2_A(0.0899) Cluster-exclusive L:1 0.0899 1 1 skcm:1 ENST00000262367 5 3d CREBBP A1782 1782 860 3io2_A(0.0899) Cluster-exclusive T:2 0.0899 2 2 coadread:1|ucec:1 ENST00000262367 5 3d CREBBP C1795 1795 860 3io2_A(0.0899) Cluster-exclusive R:1 0.0899 1 1 pias:1 ENST00000262367 5 3d CREBBP V1802 1802 860 3io2_A(0.0899) Cluster-exclusive M:1 0.0899 1 1 stad:1 ENST00000262367 5 3d BRAF F595 595 864 3tv4_A(0.0907);4e4x_A(0.0926);3tv6_B(0.0964);4e4x_B(0.0974);4ehe_A(0.0957) Hotspot-linked L:1 0.0907 1 1 blca:1 ENST00000288602 6 3d BRAF G596 596 864 3tv4_A(0.0907);4e4x_A(0.0926);3tv6_B(0.0964);4e4x_B(0.0974);4ehe_A(0.0957) Hotspot R:2|S:1|D:1|V:1 0.0907 5 4 mmyl:1|gbm:1|blca:1|luad:2 ENST00000288602 6 3d BRAF L597 597 864 3tv4_A(0.0907);4e4x_A(0.0926);3tv6_B(0.0964);4e4x_B(0.0974);4ehe_A(0.0957) Hotspot Q:2|R:1|S:1 0.0907 4 3 mmyl:1|prad:1|skcm:2 ENST00000288602 6 3d BRAF V600 600 864 3tv4_A(0.0907);4e4x_A(0.0926);3tv6_B(0.0964);4e4x_B(0.0974);4ehe_A(0.0957) Hotspot R:4|E:509|K:32 0.0907 545 10 mmyl:5|coadread:44|gbm:6|thca:237|hnsc:1|skcm:239|hgg:2|lgg:1|kirp:1|luad:9 ENST00000288602 6 3d BRAF K601 601 864 3tv4_A(0.0907);4e4x_A(0.0926);3tv6_B(0.0964);4e4x_B(0.0974);4ehe_A(0.0957) Hotspot T:1|E:12|N:2 0.0907 15 7 prad:1|cll:1|stad:2|thca:1|skcm:6|ucec:1|luad:3 ENST00000288602 6 3d H3C13 K123 123 867 1hq3_C(0.0907) Cluster-exclusive N:1 0.0907 1 1 brca:1 ENST00000331491 1 3d H3C13 D124 124 867 1hq3_C(0.0907) Cluster-exclusive Y:1 0.0907 1 1 brca:1 ENST00000331491 1 3d H3C13 I125 125 867 1hq3_C(0.0907) Cluster-exclusive V:1 0.0907 1 1 hnsc:1 ENST00000331491 1 3d H3C13 L127 127 867 1hq3_C(0.0907) Cluster-exclusive F:1 0.0907 1 1 coadread:1 ENST00000331491 1 3d H3C13 R130 130 867 1hq3_C(0.0907) Cluster-exclusive C:1 0.0907 1 1 brca:1 ENST00000331491 1 3d ZSCAN16 P53 53 869 1e07_A(0.0907) Cluster-exclusive H:1 0.0907 1 1 ucec:1 ENST00000340487 4 3d ZSCAN16 G54 54 869 1e07_A(0.0907) Cluster-exclusive E:1 0.0907 1 1 ucec:1 ENST00000340487 4 3d TP53 C135 135 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot R:3|S:2|F:9|W:2|G:1|Y:9 0.0908 26 12 acc:1|brca:5|paad:1|coadread:3|prad:2|stad:2|esca:5|blca:1|ov:2|lusc:1|lgg:1|luad:2 ENST00000269305 4 3d TP53 Q136 136 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot-linked P:1|E:7|H:1 0.0908 9 6 brca:1|stad:1|gbm:1|hnsc:3|lihc:1|lgg:2 ENST00000269305 4 3d TP53 L137 137 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot-linked Q:1 0.0908 1 1 hnsc:1 ENST00000269305 4 3d TP53 A138 138 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot-linked P:1|T:1|V:4 0.0908 6 5 coadread:2|gbm:1|hnsc:1|ov:1|cscc:1 ENST00000269305 4 3d TP53 K139 139 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot-linked E:2|N:3 0.0908 5 3 blca:1|lihc:3|lymbc:1 ENST00000269305 4 3d TP53 C141 141 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot R:2|S:1|F:1|W:6|G:2|Y:10 0.0908 22 12 brca:5|mmyl:1|paad:1|coadread:3|prad:3|kich:1|hnsc:2|laml:1|ucec:1|lusc:1|lgg:2|luad:1 ENST00000269305 4 3d TP53 L194 194 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot P:2|R:15|F:3|H:3 0.0908 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 I195 195 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot S:2|T:25|F:11|M:2|N:5 0.0908 45 16 brca:7|paad:1|mmyl:2|coadread:4|cll:1|esca:2|ucs:1|hnsc:4|laml:1|ov:11|lihc:3|lusc:1|lgg:3|stad:1|gbm:2|luad:1 ENST00000269305 4 3d TP53 Y234 234 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot C:23|S:2|D:1|H:2|N:1 0.0908 29 14 acc:1|brca:4|paad:1|coadread:1|esca:2|blca:1|hnsc:3|ov:4|lihc:2|lusc:3|lusm:1|prad:1|stad:2|gbm:3 ENST00000269305 4 3d TP53 Y236 236 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot C:16|D:2|N:2 0.0908 20 11 brca:1|paad:1|coadread:1|prad:1|stad:1|hnsc:6|ov:2|lusc:1|lgg:3|luad:2|cscc:1 ENST00000269305 4 3d TP53 M237 237 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot V:3|I:17|K:4 0.0908 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0908 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 V272 272 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot E:1|G:4|K:1|L:1|M:17 0.0908 24 12 brca:2|paad:3|mmyl:1|coadread:2|stad:2|hnsc:3|mbl:1|ov:4|ucec:1|kirc:1|luad:3|cscc:1 ENST00000269305 4 3d TP53 V274 274 870 2bip_A(0.0909);2biq_A(0.0926);4agn_A(0.0982);4agl_A(0.0988);2bin_A(0.0908) Hotspot A:4|D:5|F:7|G:4|L:1 0.0908 21 11 brca:3|paad:2|coadread:2|prad:1|lusm:1|stad:1|ov:2|skcm:1|lihc:3|lgg:1|luad:4 ENST00000269305 4 3d EGFR V769 769 874 3w32_A(0.091) Hotspot-linked L:1 0.091 1 1 luad:1 ENST00000275493 2 3d EGFR R831 831 874 3w32_A(0.091) Hotspot-linked H:2 0.091 2 2 coadread:1|luad:1 ENST00000275493 2 3d EGFR R832 832 874 3w32_A(0.091) Hotspot-linked C:1|H:1 0.091 2 2 ucec:1|kirc:1 ENST00000275493 2 3d EGFR L833 833 874 3w32_A(0.091) Hotspot-linked F:1|V:1 0.091 2 1 luad:2 ENST00000275493 2 3d EGFR G857 857 874 3w32_A(0.091) Hotspot-linked V:1 0.091 1 1 luad:1 ENST00000275493 2 3d EGFR H893 893 874 3w32_A(0.091) Hotspot-linked Y:1 0.091 1 1 coadread:1 ENST00000275493 2 3d TP53 V173 173 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot A:2|E:1|G:2|L:15|M:12 0.0914 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot-linked S:1|W:2|K:1 0.0914 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot C:4|G:7|H:143 0.0914 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0914 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot-linked R:2|T:1|L:3 0.0914 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0914 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot-linked D:1|K:2 0.0914 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 P190 190 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot-linked R:1|L:5 0.0914 6 6 coadread:1|kich:1|gbm:1|lihc:1|lymbc:1|lgg:1 ENST00000269305 4 3d TP53 P191 191 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot-linked L:1 0.0914 1 1 skcm:1 ENST00000269305 4 3d TP53 H193 193 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot P:7|R:32|D:2|Y:13|L:11|N:1 0.0914 66 20 brca:13|paad:2|coadread:1|cll:1|esca:3|ucs:3|blca:1|hnsc:9|laml:1|ov:8|hgg:1|lihc:4|lusc:4|lgg:4|kirp:1|lusm:1|prad:1|stad:1|ucec:2|luad:5 ENST00000269305 4 3d TP53 L194 194 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot P:2|R:15|F:3|H:3 0.0914 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 M237 237 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot V:3|I:17|K:4 0.0914 24 12 brca:1|paad:1|coadread:1|stad:2|esca:3|hnsc:3|ov:4|hgg:1|ucec:1|lusc:1|lgg:3|luad:3 ENST00000269305 4 3d TP53 C238 238 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0914 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 G244 244 877 2j1y_B(0.0926);2j1y_D(0.0914) Hotspot R:1|C:8|S:5|D:9|V:2 0.0914 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d POTEE S933 933 879 3j0s_A(0.0917) Cluster-exclusive C:1|I:1 0.0917 2 2 skcm:1|luad:1 ENST00000356920 5 3d POTEE S935 935 879 3j0s_A(0.0917) Cluster-exclusive F:1 0.0917 1 1 skcm:1 ENST00000356920 5 3d POTEE E937 937 879 3j0s_A(0.0917) Cluster-exclusive K:2 0.0917 2 2 skcm:1|lusc:1 ENST00000356920 5 3d POTEE K938 938 879 3j0s_A(0.0917) Cluster-exclusive R:1|M:1 0.0917 2 2 stad:1|skcm:1 ENST00000356920 5 3d POTEE S939 939 879 3j0s_A(0.0917) Cluster-exclusive R:1|N:1 0.0917 2 2 stad:1|skcm:1 ENST00000356920 5 3d POTEE T949 949 879 3j0s_A(0.0917) Cluster-exclusive I:1 0.0917 1 1 skcm:1 ENST00000356920 5 3d PECR K291 291 881 1yxm_C(0.0917) Cluster-exclusive E:1 0.0917 1 1 lihc:1 ENST00000265322 7 3d PECR E295 295 881 1yxm_C(0.0917) Cluster-exclusive K:1 0.0917 1 1 cscc:1 ENST00000265322 7 3d ANK1 A921 921 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive T:1 0.0924 1 1 skcm:1 ENST00000347528 4 3d ANK1 R922 922 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive W:1 0.0924 1 1 hgg:1 ENST00000347528 4 3d ANK1 G923 923 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive R:1|S:1 0.0924 2 2 skcm:1|lihc:1 ENST00000347528 4 3d ANK1 P940 940 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive Q:1 0.0924 1 1 luad:1 ENST00000347528 4 3d ANK1 R941 941 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive Q:1 0.0924 1 1 thca:1 ENST00000347528 4 3d ANK1 T942 942 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive M:1 0.0924 1 1 brca:1 ENST00000347528 4 3d ANK1 L1033 1033 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive I:1 0.0924 1 1 ucec:1 ENST00000347528 4 3d ANK1 M1036 1036 885 3ud1_B(0.0924);3ud1_C(0.098) Cluster-exclusive I:2 0.0924 2 1 skcm:2 ENST00000347528 4 3d TP53 Y163 163 887 3q01_A(0.0925) Hotspot C:27|D:2|H:4|N:4 0.0925 37 14 brca:4|paad:1|coadread:1|esca:2|ucs:1|hnsc:7|ov:7|hgg:1|lihc:2|lusc:3|lgg:1|lusm:1|skcm:1|luad:5 ENST00000269305 4 3d TP53 V173 173 887 3q01_A(0.0925) Hotspot A:2|E:1|G:2|L:15|M:12 0.0925 32 15 acc:1|brca:4|paad:2|coadread:2|esca:1|hnsc:7|ov:2|hgg:1|lihc:1|lgg:3|lusm:1|stad:2|skcm:1|ucec:1|luad:3 ENST00000269305 4 3d TP53 R174 174 887 3q01_A(0.0925) Hotspot-linked S:1|W:2|K:1 0.0925 4 1 lihc:4 ENST00000269305 4 3d TP53 L194 194 887 3q01_A(0.0925) Hotspot P:2|R:15|F:3|H:3 0.0925 23 11 brca:6|paad:1|coadread:2|gbm:1|blca:2|hnsc:2|ov:3|lihc:1|cesc:1|lgg:1|luad:3 ENST00000269305 4 3d TP53 C238 238 887 3q01_A(0.0925) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0925 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 N239 239 887 3q01_A(0.0925) Hotspot S:8|D:6|T:1 0.0925 15 12 brca:1|coadread:1|kich:1|prad:1|stad:1|ucs:1|hnsc:2|ov:1|lihc:1|ucec:2|kirc:1|luad:2 ENST00000269305 4 3d TP53 S240 240 887 3q01_A(0.0925) Hotspot-linked R:1|G:2 0.0925 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 C242 242 887 3q01_A(0.0925) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0925 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 G244 244 887 3q01_A(0.0925) Hotspot R:1|C:8|S:5|D:9|V:2 0.0925 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 887 3q01_A(0.0925) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0925 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 887 3q01_A(0.0925) Hotspot-linked R:2|V:3|I:5 0.0925 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 887 3q01_A(0.0925) Hotspot-linked I:4 0.0925 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 887 3q01_A(0.0925) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0925 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d TP53 R249 249 887 3q01_A(0.0925) Hotspot S:25|T:2|W:5|G:6|K:1|M:9 0.0925 48 15 paad:2|esca:1|ucs:1|hnsc:4|ov:1|lihc:10|lusc:3|lusm:4|prad:3|stad:1|gbm:2|mbl:1|ucec:2|cscc:1|luad:12 ENST00000269305 4 3d TP53 I251 251 887 3q01_A(0.0925) Hotspot-linked S:2|F:1|N:3 0.0925 6 5 coadread:1|prad:1|hnsc:1|skcm:1|ov:2 ENST00000269305 4 3d F7 G156 156 888 1kli_L(0.0926) Cluster-exclusive D:1 0.0926 1 1 stad:1 ENST00000375581 3 3d F7 R170 170 888 1kli_L(0.0926) Cluster-exclusive C:1 0.0926 1 1 lgg:1 ENST00000375581 3 3d F7 C172 172 888 1kli_L(0.0926) Cluster-exclusive F:1 0.0926 1 1 cscc:1 ENST00000375581 3 3d F7 G184 184 888 1kli_L(0.0926) Cluster-exclusive R:2 0.0926 2 2 skcm:1|luad:1 ENST00000375581 3 3d CTPS1 E228 228 890 4eaz_A(0.0927) Cluster-exclusive D:2 0.0927 2 1 ucec:2 ENST00000372616 1 3d CTPS1 E237 237 890 4eaz_A(0.0927) Cluster-exclusive K:1 0.0927 1 1 brca:1 ENST00000372616 1 3d CTPS1 P238 238 890 4eaz_A(0.0927) Cluster-exclusive L:1 0.0927 1 1 cscc:1 ENST00000372616 1 3d CTPS1 E239 239 890 4eaz_A(0.0927) Cluster-exclusive Q:1 0.0927 1 1 luad:1 ENST00000372616 1 3d CTPS1 S300 300 890 4eaz_A(0.0927) Cluster-exclusive C:1 0.0927 1 1 luad:1 ENST00000372616 1 3d H3C13 K123 123 892 4h9s_B(0.0927) Cluster-exclusive N:1 0.0927 1 1 brca:1 ENST00000331491 1 3d H3C13 D124 124 892 4h9s_B(0.0927) Cluster-exclusive Y:1 0.0927 1 1 brca:1 ENST00000331491 1 3d H3C13 I125 125 892 4h9s_B(0.0927) Cluster-exclusive V:1 0.0927 1 1 hnsc:1 ENST00000331491 1 3d H3C13 L127 127 892 4h9s_B(0.0927) Cluster-exclusive F:1 0.0927 1 1 coadread:1 ENST00000331491 1 3d H3C13 R130 130 892 4h9s_B(0.0927) Cluster-exclusive C:1 0.0927 1 1 brca:1 ENST00000331491 1 3d H3C13 T119 119 893 4h9s_B(0.0927) Cluster-exclusive A:1 0.0927 1 1 lihc:1 ENST00000331491 1 3d H3C13 K123 123 893 4h9s_B(0.0927) Cluster-exclusive N:1 0.0927 1 1 brca:1 ENST00000331491 1 3d H3C13 D124 124 893 4h9s_B(0.0927) Cluster-exclusive Y:1 0.0927 1 1 brca:1 ENST00000331491 1 3d H3C13 I125 125 893 4h9s_B(0.0927) Cluster-exclusive V:1 0.0927 1 1 hnsc:1 ENST00000331491 1 3d H3C13 L127 127 893 4h9s_B(0.0927) Cluster-exclusive F:1 0.0927 1 1 coadread:1 ENST00000331491 1 3d CASP7 S231 231 894 1k86_B(0.0932);3r5k_A(0.0965);4jr1_A(0.0956);4hqr_B(0.0933);1kmc_A(0.0975);1kmc_B(0.0977);1i4o_A(0.0987);4jr1_B(0.0941);3r5k_B(0.0928) Cluster-exclusive L:2 0.0928 2 2 ucs:1|skcm:1 ENST00000345633 4 3d CASP7 R233 233 894 1k86_B(0.0932);3r5k_A(0.0965);4jr1_A(0.0956);4hqr_B(0.0933);1kmc_A(0.0975);1kmc_B(0.0977);1i4o_A(0.0987);4jr1_B(0.0941);3r5k_B(0.0928) Cluster-exclusive W:1 0.0928 1 1 kirc:1 ENST00000345633 4 3d CASP7 S234 234 894 1k86_B(0.0932);3r5k_A(0.0965);4jr1_A(0.0956);4hqr_B(0.0933);1kmc_A(0.0975);1kmc_B(0.0977);1i4o_A(0.0987);4jr1_B(0.0941);3r5k_B(0.0928) Cluster-exclusive N:1 0.0928 1 1 coadread:1 ENST00000345633 4 3d CASP7 P235 235 894 1k86_B(0.0932);3r5k_A(0.0965);4jr1_A(0.0956);4hqr_B(0.0933);1kmc_A(0.0975);1kmc_B(0.0977);1i4o_A(0.0987);4jr1_B(0.0941);3r5k_B(0.0928) Cluster-exclusive S:1 0.0928 1 1 skcm:1 ENST00000345633 4 3d SRP9 A25 25 895 4uyk_A(0.0928) Cluster-exclusive T:1 0.0928 1 1 kirc:1 ENST00000304786 7 3d SRP9 R26 26 895 4uyk_A(0.0928) Cluster-exclusive H:1 0.0928 1 1 stad:1 ENST00000304786 7 3d SRP9 D44 44 895 4uyk_A(0.0928) Cluster-exclusive V:1 0.0928 1 1 paad:1 ENST00000304786 7 3d ZNF548 A238 238 898 2nl9_A(0.0937) Cluster-exclusive T:1|V:1 0.0937 2 2 paad:1|coadread:1 ENST00000366197 5 3d ZNF548 C286 286 898 2nl9_A(0.0937) Cluster-exclusive R:1 0.0937 1 1 blca:1 ENST00000366197 5 3d ZNF548 K288 288 898 2nl9_A(0.0937) Cluster-exclusive E:1 0.0937 1 1 luad:1 ENST00000366197 5 3d ZNF548 F289 289 898 2nl9_A(0.0937) Cluster-exclusive L:1 0.0937 1 1 coadread:1 ENST00000366197 5 3d ZNF548 R291 291 898 2nl9_A(0.0937) Cluster-exclusive W:1|L:1 0.0937 2 2 lihc:1|cscc:1 ENST00000366197 5 3d TP53 C176 176 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.0941 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 H179 179 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.0941 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 C238 238 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot R:3|S:3|F:12|G:1|Y:15 0.0941 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 S240 240 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot-linked R:1|G:2 0.0941 3 2 coadread:1|ucec:2 ENST00000269305 4 3d TP53 S241 241 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot P:3|A:2|C:6|F:19|Y:9 0.0941 39 20 paad:1|brca:2|coadread:1|esca:1|ucs:3|blca:2|hnsc:1|ov:7|hgg:2|gbc:2|lymbc:1|lgg:1|kirp:1|kich:1|gbm:2|skcm:4|ucec:3|kirc:1|cscc:1|luad:2 ENST00000269305 4 3d TP53 C242 242 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot S:5|F:13|G:1|W:1|Y:3 0.0941 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot-linked I:1 0.0941 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot R:1|C:8|S:5|D:9|V:2 0.0941 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.0941 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d TP53 M246 246 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot-linked R:2|V:3|I:5 0.0941 10 8 brca:1|paad:1|kich:1|lusm:1|esca:1|gbm:1|hnsc:2|lgg:2 ENST00000269305 4 3d TP53 N247 247 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot-linked I:4 0.0941 4 3 brca:1|esca:1|luad:2 ENST00000269305 4 3d TP53 R248 248 899 3zme_A(0.0987);3zme_B(0.0941);4ago_A(0.0947);4agn_B(0.0995);2j21_B(0.0962);4agn_A(0.0952);4agl_B(0.0991);2wgx_A(0.0953);2x0u_A(0.0992);4agp_B(0.0953);2vuk_B(0.0996);2bin_A(0.0951) Hotspot P:5|Q:108|W:89|G:2|L:10 0.0941 214 25 brca:9|mmyl:1|coadread:34|blca:11|hgg:5|lihc:5|lgg:10|prad:5|lusm:1|ucec:9|luad:10|paad:11|cll:1|esca:13|ucs:7|hnsc:22|laml:1|ov:19|lusc:4|stad:11|gbm:13|mbl:1|skcm:3|mds:1|cscc:7 ENST00000269305 4 3d KCNH5 H54 54 900 3gqc_B(0.0941) Cluster-exclusive Q:1 0.0941 1 1 esca:1 ENST00000322893 7 3d KCNH5 R55 55 900 3gqc_B(0.0941) Cluster-exclusive Q:1 0.0941 1 1 cscc:1 ENST00000322893 7 3d KCNH5 A56 56 900 3gqc_B(0.0941) Cluster-exclusive S:1|T:1 0.0941 2 2 stad:1|lusc:1 ENST00000322893 7 3d KCNH5 V58 58 900 3gqc_B(0.0941) Cluster-exclusive I:1 0.0941 1 1 stad:1 ENST00000322893 7 3d CALM1 I64 64 905 1qx7_M(0.0942) Cluster-exclusive T:1 0.0942 1 1 lihc:1 ENST00000272298 7 3d CALM1 D65 65 905 1qx7_M(0.0942) Cluster-exclusive E:1 0.0942 1 1 lihc:1 ENST00000272298 7 3d CALM1 P67 67 905 1qx7_M(0.0942) Cluster-exclusive L:1 0.0942 1 1 skcm:1 ENST00000272298 7 3d CALM1 L70 70 905 1qx7_M(0.0942) Cluster-exclusive F:2 0.0942 2 2 esca:1|luad:1 ENST00000272298 7 3d ITGAM D156 156 906 4m76_B(0.0943) Cluster-exclusive H:1 0.0943 1 1 luad:1 ENST00000287497 8 3d ITGAM S158 158 906 4m76_B(0.0943) Cluster-exclusive C:1|Y:1 0.0943 2 2 ucec:1|cesc:1 ENST00000287497 8 3d ITGAM R224 224 906 4m76_B(0.0943) Cluster-exclusive Q:2 0.0943 2 2 coadread:1|thca:1 ENST00000287497 8 3d ITGAM T225 225 906 4m76_B(0.0943) Cluster-exclusive A:1 0.0943 1 1 kich:1 ENST00000287497 8 3d ITGAM D258 258 906 4m76_B(0.0943) Cluster-exclusive N:1 0.0943 1 1 skcm:1 ENST00000287497 8 3d CLTC N1288 1288 907 1b89_A(0.0944) Cluster-exclusive K:1 0.0944 1 1 lusc:1 ENST00000269122 3 3d CLTC Y1289 1289 907 1b89_A(0.0944) Cluster-exclusive C:1 0.0944 1 1 ov:1 ENST00000269122 3 3d CLTC Y1290 1290 907 1b89_A(0.0944) Cluster-exclusive D:1 0.0944 1 1 hnsc:1 ENST00000269122 3 3d CLTC R1293 1293 907 1b89_A(0.0944) Cluster-exclusive C:1 0.0944 1 1 esca:1 ENST00000269122 3 3d CLTC G1294 1294 907 1b89_A(0.0944) Cluster-exclusive V:1 0.0944 1 1 ucec:1 ENST00000269122 3 3d PARP1 L77 77 909 4av1_A(0.0944);4av1_C(0.0967);3od8_F(0.0954);3od8_G(0.0979) Cluster-exclusive I:1 0.0944 1 1 brca:1 ENST00000366794 5 3d PARP1 R78 78 909 4av1_A(0.0944);4av1_C(0.0967);3od8_F(0.0954);3od8_G(0.0979) Cluster-exclusive W:1 0.0944 1 1 paad:1 ENST00000366794 5 3d PARP1 W79 79 909 4av1_A(0.0944);4av1_C(0.0967);3od8_F(0.0954);3od8_G(0.0979) Cluster-exclusive L:1 0.0944 1 1 ucec:1 ENST00000366794 5 3d PARP1 D81 81 909 4av1_A(0.0944);4av1_C(0.0967);3od8_F(0.0954);3od8_G(0.0979) Cluster-exclusive G:1 0.0944 1 1 coadread:1 ENST00000366794 5 3d ITGB1 M149 149 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive V:1|I:1|L:1 0.0955 3 3 brca:1|skcm:1|lusc:1 ENST00000302278 3 3d ITGB1 V275 275 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive G:2 0.0955 2 2 brca:1|mmyl:1 ENST00000302278 3 3d ITGB1 F276 276 915 4wk0_B(0.0955);4wjk_B(0.0993) Cluster-exclusive L:1 0.0955 1 1 brca:1 ENST00000302278 3 3d VHL V130 130 919 4b95_C(0.0979);4b9k_C(0.0985);4b95_F(0.0964);4wqo_A(0.0973) Hotspot-linked D:1|F:1 0.0964 2 1 kirc:2 ENST00000256474 2 3d PPP2R1A R105 105 922 4i5n_D(0.097) Hotspot-linked Q:1 0.097 1 1 ucec:1 ENST00000322088 6 3d PPP2R1A S143 143 922 4i5n_D(0.097) Hotspot-linked F:1 0.097 1 1 skcm:1 ENST00000322088 6 3d PPP2R1A R144 144 922 4i5n_D(0.097) Hotspot-linked C:1|H:1 0.097 2 2 ucec:1|lusc:1 ENST00000322088 6 3d PPP2R1A T145 145 922 4i5n_D(0.097) Hotspot-linked P:1 0.097 1 1 ov:1 ENST00000322088 6 3d PPP2R1A S146 146 922 4i5n_D(0.097) Hotspot-linked L:3 0.097 3 3 ucs:1|skcm:1|luad:1 ENST00000322088 6 3d PPP2R1A C148 148 922 4i5n_D(0.097) Hotspot-linked F:1 0.097 1 1 luad:1 ENST00000322088 6 3d PPP2R1A R183 183 922 4i5n_D(0.097) Hotspot Q:4|W:14|G:1 0.097 19 9 brca:1|coadread:5|prad:1|stad:1|ucs:3|hnsc:1|ov:3|ucec:2|luad:2 ENST00000322088 6 3d AMY1C H314 314 924 4gqq_A(0.097) Cluster-exclusive Y:1 0.097 1 1 coadread:1 ENST00000370079 3 3d AMY1C S326 326 924 4gqq_A(0.097) Cluster-exclusive Y:1 0.097 1 1 luad:1 ENST00000370079 3 3d AMY1C I327 327 924 4gqq_A(0.097) Cluster-exclusive T:1 0.097 1 1 luad:1 ENST00000370079 3 3d RBBP7 E313 313 927 2xu7_A(0.0972) Cluster-exclusive K:2 0.0972 2 1 coadread:2 ENST00000380087 2 3d RBBP7 S314 314 927 2xu7_A(0.0972) Cluster-exclusive Y:1 0.0972 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 927 2xu7_A(0.0972) Cluster-exclusive Y:1 0.0972 1 1 skcm:1 ENST00000380087 2 3d RBBP7 R340 340 927 2xu7_A(0.0972) Cluster-exclusive C:1|H:2 0.0972 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 927 2xu7_A(0.0972) Cluster-exclusive T:1|H:1 0.0972 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d RBBP7 S314 314 928 2xu7_A(0.0972) Cluster-exclusive Y:1 0.0972 1 1 ucec:1 ENST00000380087 2 3d RBBP7 H315 315 928 2xu7_A(0.0972) Cluster-exclusive Y:1 0.0972 1 1 skcm:1 ENST00000380087 2 3d RBBP7 R340 340 928 2xu7_A(0.0972) Cluster-exclusive C:1|H:2 0.0972 3 2 mmyl:1|coadread:2 ENST00000380087 2 3d RBBP7 N342 342 928 2xu7_A(0.0972) Cluster-exclusive T:1|H:1 0.0972 2 2 hnsc:1|ucec:1 ENST00000380087 2 3d RBBP7 H369 369 928 2xu7_A(0.0972) Cluster-exclusive L:1 0.0972 1 1 blca:1 ENST00000380087 2 3d TP53 R174 174 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked S:1|W:2|K:1 0.099 4 1 lihc:4 ENST00000269305 4 3d TP53 R175 175 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot C:4|G:7|H:143 0.099 154 22 brca:18|npc:1|paad:9|coadread:36|cll:1|esca:12|ucs:2|blca:4|hnsc:16|ov:16|gbc:1|hgg:2|lihc:1|lusc:3|lgg:4|prad:3|stad:11|gbm:7|mbl:1|skcm:1|ucec:2|luad:3 ENST00000269305 4 3d TP53 C176 176 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot R:1|S:3|F:26|W:1|G:2|Y:21 0.099 54 15 brca:5|paad:4|coadread:5|esca:5|blca:1|hnsc:5|laml:1|ov:10|lihc:1|lusc:2|lgg:4|kich:1|prad:1|stad:5|luad:4 ENST00000269305 4 3d TP53 P177 177 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked R:2|T:1|L:3 0.099 6 3 ov:2|skcm:3|luad:1 ENST00000269305 4 3d TP53 H179 179 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot P:1|Q:7|R:37|D:2|Y:16|L:5|N:3 0.099 71 19 brca:9|paad:5|coadread:1|esca:3|ucs:3|hnsc:13|laml:1|ov:6|gbc:1|lihc:3|lusc:5|lgg:7|lusm:1|stad:3|gbm:3|skcm:1|ucec:1|luad:3|cscc:2 ENST00000269305 4 3d TP53 E180 180 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked D:1|K:2 0.099 3 3 lusm:1|hnsc:1|luad:1 ENST00000269305 4 3d TP53 C238 238 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot R:3|S:3|F:12|G:1|Y:15 0.099 34 17 brca:4|paad:2|mmyl:1|coadread:3|cll:1|esca:2|ucs:2|blca:1|hnsc:3|ov:4|lihc:1|lgg:1|stad:1|gbm:4|ucec:2|cesc:1|luad:1 ENST00000269305 4 3d TP53 C242 242 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot S:5|F:13|G:1|W:1|Y:3 0.099 23 11 brca:1|cll:2|stad:2|esca:1|gbm:1|ucs:1|blca:1|hnsc:5|lihc:2|lusc:3|luad:4 ENST00000269305 4 3d TP53 M243 243 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot-linked I:1 0.099 1 1 ucs:1 ENST00000269305 4 3d TP53 G244 244 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot R:1|C:8|S:5|D:9|V:2 0.099 25 13 coadread:3|esca:2|ucs:1|hnsc:1|ov:5|lihc:1|lusc:2|lgg:1|lusm:1|stad:2|gbm:2|ucec:2|luad:2 ENST00000269305 4 3d TP53 G245 245 937 3ts8_A(0.0991);4mzi_A(0.099) Hotspot A:2|R:2|S:46|C:9|D:22|V:16 0.099 97 16 paad:8|brca:5|coadread:12|esca:6|ucs:1|blca:2|hnsc:14|ov:13|hgg:1|lihc:2|lusc:4|lgg:4|prad:5|stad:6|gbm:3|luad:11 ENST00000269305 4 3d SERPINB3 N8 8 938 2zv6_A(0.099) Cluster-exclusive K:1 0.099 1 1 luad:1 ENST00000283752 5 3d SERPINB3 T9 9 938 2zv6_A(0.099) Cluster-exclusive N:1 0.099 1 1 luad:1 ENST00000283752 5 3d SERPINB3 K10 10 938 2zv6_A(0.099) Cluster-exclusive N:1 0.099 1 1 luad:1 ENST00000283752 5 3d SERPINB3 F11 11 938 2zv6_A(0.099) Cluster-exclusive L:1 0.099 1 1 coadread:1 ENST00000283752 5 3d SERPINB3 D14 14 938 2zv6_A(0.099) Cluster-exclusive H:1 0.099 1 1 hnsc:1 ENST00000283752 5 3d SERPINB3 L15 15 938 2zv6_A(0.099) Cluster-exclusive M:1 0.099 1 1 prad:1 ENST00000283752 5 3d RHOA T37 37 942 1ow3_B(0.0995) Hotspot-linked S:1|I:1 0.0995 2 2 coadread:1|hnsc:1 ENST00000418115 1 3d RHOA F39 39 942 1ow3_B(0.0995) Hotspot-linked C:1 0.0995 1 1 stad:1 ENST00000418115 1 3d RHOA D59 59 942 1ow3_B(0.0995) Hotspot-linked G:1|Y:1|N:1 0.0995 3 3 prad:1|stad:1|luad:1 ENST00000418115 1 3d RHOA T60 60 942 1ow3_B(0.0995) Hotspot-linked K:1 0.0995 1 1 stad:1 ENST00000418115 1 3d RHOA A61 61 942 1ow3_B(0.0995) Hotspot-linked D:1|V:1 0.0995 2 2 coadread:1|stad:1 ENST00000418115 1 3d