INCENTIVE Project Controlled Vocabulary
type: ConceptScheme
creator: https://orcid.org/0000-0003-2195-3997
description: Quantitative and qualitative variables describing ...
has version: 0.1.1
rights: CC0-1.0
created on: 2021-08-23T16:13+00:00
last updated on: 2023-11-23T18:01:10+00:00
has top concept: assay
has top concept: variable
has top concept: subject
has top concept: property
has top concept: entity
has top concept: constraint

assay
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: multiplex bead-based assay
narrower: flow cytometry assay
narrower: cytometric bead array assay
narrower: RNA-seq assay
narrower: antigen specific antibodies assay
narrower: liquid chromatography mass spectrometry assay
narrower: plasma proteomics assay
narrower: singleplex bead-based assay
top concept of: INCENTIVE Project Controlled Vocabulary

variable
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: levels IgG1-rHA_C
narrower: levels IgG1-rHA_C with urea
narrower: avidity levels IgG1-rHA_C
narrower: levels IgG1-rHA_B
narrower: levels IgG1-rHA_B with urea
narrower: avidity levels IgG1-rHA_B
narrower: relative concentration of lipids in plasma
narrower: absolute concentration of metablites in plasma
narrower: relative concentration of proteins in plasma
narrower: count of reads of RNAs
narrower: corrected P-value of RNAs
narrower: fold change of RNAs
narrower: retention time of lipids in plasma
narrower: mass to charge of lipids in plasma
narrower: chemical shift of metabolites in plasma
narrower: intensity of metabolites in plasma
narrower: fluorescence of multiple cytokines with luminex
narrower: fluorescence of multiple cytokines with simoa
narrower: cytokine concentration
narrower: average enzyme per beads
narrower: fluorescence intensity of immune cell populations in human blood samples
narrower: median fluorescence intensity of antibodies bound to markers on immune cells in human blood samples
narrower: frequeny of immune cell populations (phenotype and functionality) in human blood samples
narrower: counts of immune cell populations (phenotype and functionality) in human blood samples
narrower: fluorescence intensity of antibody bound to soluble factors in human blood samples
narrower: mean fluorescence intensity of antibody bound to soluble factors in human blood samples
narrower: retention time of peptides in plasma
narrower: mass to charge of peptides in plasma
narrower: intensity of peptides in plasma
narrower: concentration of soluble factors in human blood samples
top concept of: INCENTIVE Project Controlled Vocabulary

antigen specific antibodies assay
type: Concept
broader: assay
definition: An analyte assay that measures the presence or amount of antibodies to a specified antigen.
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: quantitative suspension multiplex assay to measure IgG subclasses and avidity to influenza virus antigens

quantitative suspension multiplex assay to measure IgG subclasses and avidity to influenza virus antigens
type: Concept
broader: antigen specific antibodies assay
definition: multiplex assay that measures the amount and avidity of a specific IgG subclass to several influenza virus antigens
in scheme: INCENTIVE Project Controlled Vocabulary

liquid chromatography mass spectrometry assay
type: Concept
broader: assay
definition: A mass spectrometry assay where a sample mixture is first separated by liquid chromatography before being converted into ions which are characterized by using mass spectrometry based on their mass-to-charge ratio and relative abundance.
in scheme: INCENTIVE Project Controlled Vocabulary

plasma proteomics assay
type: Concept
broader: assay
definition: A proteomics profiling assay that detects proteins in a blood plasma specimen.
in scheme: INCENTIVE Project Controlled Vocabulary

RNA-seq assay
type: Concept
broader: assay
definition: An RNA sequencing assay that determines an RNA sequence by analyzing the transcibed regions of the genome and or to quantitate transcript abundance.
in scheme: INCENTIVE Project Controlled Vocabulary

multiplex bead-based assay
type: Concept
broader: assay
definition: A molecular assay that permits the simultaneous measurement of an array of proteins in a single, small volume sample.
in scheme: INCENTIVE Project Controlled Vocabulary

singleplex bead-based assay
type: Concept
source: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp
broader: assay
definition: A type of solid-phase multiplex assay that uses microbeads coated with recombinant or infinity purified antigens from a single allele for the detection and identification of an antibody that would bind and react to this antigen.
in scheme: INCENTIVE Project Controlled Vocabulary

flow cytometry assay
type: Concept
broader: assay
definition: A cytometry assay in which an input cell population is put in solution, is passed by a laser, and optical sensors are used to detect scattering of the laser light and/or fluorescence of specific markers to count and characterize the particles in solution.
in scheme: INCENTIVE Project Controlled Vocabulary

cytometric bead array assay
type: Concept
broader: assay
definition: An analyte assay in which a series of beads coated with antibodies, antigens, or other small molecules are used to detect an analyte of interest.
in scheme: INCENTIVE Project Controlled Vocabulary

subject
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: biomarker
narrower: immunoresponse
narrower: mechanism of action
narrower: cell functionality
narrower: cell phenotype
narrower: antibody crossreactivity between vaccine antigens
narrower: functionality of vaccine induced antibodies
narrower: antibodies as biomarkers of vaccine protection
narrower: vaccine response evaluation
narrower: biomarker links pre-vaccination response to vaccine response
top concept of: INCENTIVE Project Controlled Vocabulary

antibody crossreactivity between vaccine antigens
type: Concept
broader: subject
in scheme: INCENTIVE Project Controlled Vocabulary

functionality of vaccine induced antibodies
type: Concept
broader: subject
in scheme: INCENTIVE Project Controlled Vocabulary

antibodies as biomarkers of vaccine protection
type: Concept
broader: subject
in scheme: INCENTIVE Project Controlled Vocabulary

biomarker
type: Concept
broader: subject
definition: A substance used as an indicator of a biological state.
in scheme: INCENTIVE Project Controlled Vocabulary

immunoresponse
type: Concept
broader: subject
definition: A marked decrease in contrast enhancement that is not due to actual tumor shrinkage, but that may be due to immunotherapy.
in scheme: INCENTIVE Project Controlled Vocabulary

mechanism of action
type: Concept
broader: subject
definition: The mechanism by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system.
in scheme: INCENTIVE Project Controlled Vocabulary

vaccine response evaluation
type: Concept
broader: subject
in scheme: INCENTIVE Project Controlled Vocabulary

biomarker links pre-vaccination response to vaccine response
type: Concept
broader: subject
in scheme: INCENTIVE Project Controlled Vocabulary

cell phenotype
type: Concept
broader: subject
definition: A microbial phenotype that is observed at the level of an individual cell. This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we recommend that it not be used for direct annotation. Please consider using a more specific term to annotate each phenotype.
in scheme: INCENTIVE Project Controlled Vocabulary

cell functionality
type: Concept
broader: subject
definition: The functionality of a cell.
in scheme: INCENTIVE Project Controlled Vocabulary

levels IgG1-rHA_C
type: Concept
broader: variable
definition: levels of immunoglobulin 1 against recombinant hemaglutionin from the strain A/California/04/2009 wt rHA H1 7871
in scheme: INCENTIVE Project Controlled Vocabulary

levels IgG1-rHA_C with urea
type: Concept
broader: variable
definition: levels of immunoglobulin 1 against recombinant hemaglutionin from the strain A/California/04/2009 wt rHA H1 7871 with urea
in scheme: INCENTIVE Project Controlled Vocabulary

avidity levels IgG1-rHA_C
type: Concept
broader: variable
definition: avidity of immunoglobulin 1 against recombinant hemaglutionin from the strain A/California/04/2009 wt rHA H1 7871
in scheme: INCENTIVE Project Controlled Vocabulary

levels IgG1-rHA_B
type: Concept
broader: variable
definition: levels of immunoglobulin 1 against recombinant hemaglutionin from the strain A/Brisbane/02/2018 wt rHA H1 20235
in scheme: INCENTIVE Project Controlled Vocabulary

levels IgG1-rHA_B with urea
type: Concept
broader: variable
definition: levels of immunoglobulin 1 against recombinant hemaglutionin from the strain A/Brisbane/02/2018 wt rHA H1 20235 with urea
in scheme: INCENTIVE Project Controlled Vocabulary

avidity levels IgG1-rHA_B
type: Concept
broader: variable
definition: avidity of immunoglobulin 1 against recombinant hemaglutionin from the strain A/Brisbane/02/2018 wt rHA H1 20235
in scheme: INCENTIVE Project Controlled Vocabulary

relative concentration of lipids in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

absolute concentration of metablites in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

relative concentration of proteins in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

count of reads of RNAs
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

corrected P-value of RNAs
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

fold change of RNAs
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

retention time of lipids in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

mass to charge of lipids in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

chemical shift of metabolites in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

intensity of metabolites in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

fluorescence of multiple cytokines with luminex
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

fluorescence of multiple cytokines with simoa
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

cytokine concentration
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

average enzyme per beads
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

fluorescence intensity of immune cell populations in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

median fluorescence intensity of antibodies bound to markers on immune cells in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

frequeny of immune cell populations (phenotype and functionality) in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

counts of immune cell populations (phenotype and functionality) in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

fluorescence intensity of antibody bound to soluble factors in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

mean fluorescence intensity of antibody bound to soluble factors in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

property
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: retention time
narrower: mean fluorescence intensity unit
narrower: flourescence
narrower: count
narrower: level
narrower: concentration
narrower: frequency
top concept of: INCENTIVE Project Controlled Vocabulary

retention time
type: Concept
broader: property
definition: A time interval from the start of chromatography when an analyte exits a chromatographic column.
in scheme: INCENTIVE Project Controlled Vocabulary

retention time of peptides in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

mass to charge of peptides in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

intensity of peptides in plasma
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary

entity
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: metabolite
narrower: blood
narrower: plasma
narrower: human
narrower: antibody
narrower: enzyme
narrower: cytokine
narrower: lipid
narrower: peptide
narrower: cultured immune cell population
narrower: IgG1-rHA_C
narrower: IgG1-rHA_B
narrower: IgG2-rHA_C
narrower: human donor
narrower: protein
narrower: RNA
top concept of: INCENTIVE Project Controlled Vocabulary

protein
type: Concept
broader: entity
definition: A protein or polypeptide is a long polymer of amino acids joined together by peptide bonds. The sequence of the amino acids is defined by the genetic code. Here, a protein is a perturbagen whereby its ability to modulate a physiological process or a disease pathology is assessed.
in scheme: INCENTIVE Project Controlled Vocabulary

plasma
type: Concept
broader: entity
definition: Plasma is the fluid (noncellular) portion of the circulating blood, as distinguished from the serum that is the fluid portion of the blood obtained by removal of the fibrin clot and blood cells after coagulation.
in scheme: INCENTIVE Project Controlled Vocabulary

peptide
type: Concept
broader: entity
definition: A compound of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
in scheme: INCENTIVE Project Controlled Vocabulary

human
type: Concept
broader: entity
definition: The bipedal primate mammal, Homo sapiens; belonging to man or mankind; pertaining to man or to the race of man; use of man as experimental subject or unit of analysis in research.
in scheme: INCENTIVE Project Controlled Vocabulary

lipid
type: Concept
broader: entity
definition: A class of hydrocarbon-containing organic compounds. Lipids are insoluble in water but soluble in nonpolar solvents and play important roles in living organisms: these roles include functioning as energy storage molecules, serving as structural components of cell membranes, and constituting important signaling molecules. Lipids can be subdivided into 2 groups: fatty acids and glycerides.
in scheme: INCENTIVE Project Controlled Vocabulary

metabolite
type: Concept
broader: entity
definition: Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
in scheme: INCENTIVE Project Controlled Vocabulary

RNA
type: Concept
broader: entity
definition: RNA or ribonucleic acid is a polymer of nucleotides with a backbone made of ribose sugar and phosphate groups linked together by ester bonds. RNA has the base uracil instead of thymine, which is present in DNA.
in scheme: INCENTIVE Project Controlled Vocabulary

blood
type: Concept
broader: entity
definition: A liquid tissue; its major function is to transport oxygen throughout the body. It also supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection. Several hormones also travel in the blood.
in scheme: INCENTIVE Project Controlled Vocabulary

IgG1-rHA_C
type: Concept
broader: entity
in scheme: INCENTIVE Project Controlled Vocabulary

IgG1-rHA_B
type: Concept
broader: entity
in scheme: INCENTIVE Project Controlled Vocabulary

IgG2-rHA_C
type: Concept
broader: entity
in scheme: INCENTIVE Project Controlled Vocabulary

cytokine
type: Concept
broader: entity
definition: A class of soluble glycoproteins which act nonenzymatically through specific receptors to regulate immune responses. Cytokines are derived from both immune and non-immune cells and are intercellular mediators that differ from hormones in that they are produced by a number of tissue or cell types rather than by specialized glands.
in scheme: INCENTIVE Project Controlled Vocabulary

antibody
type: Concept
broader: entity
definition: A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen.
in scheme: INCENTIVE Project Controlled Vocabulary

enzyme
type: Concept
broader: entity
definition: Molecules that catalyze a chemical reaction. They are usually proteins, although catalytic RNA and DNA molecules have been identified.
in scheme: INCENTIVE Project Controlled Vocabulary

cultured immune cell population
type: Concept
broader: entity
definition: a cultured cell population comprised of a single type of immune system cell
in scheme: INCENTIVE Project Controlled Vocabulary

count
type: Concept
broader: property
definition: Determining the number or amount of something.
in scheme: INCENTIVE Project Controlled Vocabulary

flourescence
type: Concept
broader: property
definition: Fluorescence is a luminescence (i.e., optical phenomenon) in cold bodies, in which a molecule absorbs a high-energy photon, and re-emits it as a lower-energy (longer-wavelength) photon. The energy difference between the absorbed and emitted photons ends up as molecular vibrations (heat).
in scheme: INCENTIVE Project Controlled Vocabulary

human donor
type: Concept
broader: entity
in scheme: INCENTIVE Project Controlled Vocabulary

mean fluorescence intensity unit
type: Concept
broader: property
definition: A unit of measure for the mean fluorescence intensity.
in scheme: INCENTIVE Project Controlled Vocabulary

frequency
type: Concept
broader: property
definition: Frequency is the number of occurrences of a repeating event per unit time
in scheme: INCENTIVE Project Controlled Vocabulary

constraint
type: Concept
in scheme: INCENTIVE Project Controlled Vocabulary
narrower: vaccinated
narrower: alive
narrower: diluted
top concept of: INCENTIVE Project Controlled Vocabulary

vaccinated
type: Concept
broader: constraint
definition: A status indicating that an individual has received a vaccination.
in scheme: INCENTIVE Project Controlled Vocabulary

diluted
type: Concept
broader: constraint
definition: A concentration which relatively low.
in scheme: INCENTIVE Project Controlled Vocabulary

level
type: Concept
broader: property
definition: A position on a scale measuring intensity, quality, or amount.
in scheme: INCENTIVE Project Controlled Vocabulary

alive
type: Concept
broader: constraint
definition: Showing characteristics of life; displaying signs of life.
in scheme: INCENTIVE Project Controlled Vocabulary

concentration of soluble factors in human blood samples
type: Concept
broader: variable
in scheme: INCENTIVE Project Controlled Vocabulary
has constraint: vaccinated
has context object: http://purl.org/incentive/1072
has matrix: blood
has object of interest: cytokine
has property: concentration

concentration
type: Concept
broader: property
definition: concentration is the amount of substance per unit volume of a solution
in scheme: INCENTIVE Project Controlled Vocabulary