# ALPHAPROTEIN NOVO GENERATOR OUTPUT TERMS OF USE **Last Modified:** 2026-10-05 By using Output (as defined below), without having agreed to the [AP Novo Generator Model Parameters Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md), you agree to be bound by these AP Novo Generator Output Terms of Use between you (or your organization, as applicable) and Google LLC (these "**Terms**"). If you are using Output on behalf of an organization, you confirm you are authorized either explicitly or implicitly to agree to, and are agreeing to, these Terms as an employee on behalf of, or otherwise on behalf of, your organization. If you have agreed to the [AP Novo Generator Model Parameters Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md), your use of Output is governed by those terms. **If you have not agreed to the [AP Novo Generator Model Parameters Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md) and do not agree to these Terms, do not use Output or permit any third party to do so on your behalf.** When we say "**you**", we mean the individual or organization using Output. When we say "**we**", "**us**" or "**Google**", we mean the entities that belong to the Google group of companies, which means Google LLC and its affiliates. ## Key Definitions As used in these Terms: - "**AP Novo Generator**" means the generative diffusion model for *de novo* protein structure and sequence generation, consisting of (a) the AP Novo Generator Code and (b) the Model Parameters. - **"AP Novo Generator Code"** means the source code made available at [https://github.com/google-deepmind/alphaprotein-novo](https://github.com/google-deepmind/alphaprotein-novo) and licensed under the terms of the Apache 2.0 license and any derivative source code. - **“Derived Output”** means output from any model or tool that forms part of the AP Novo Pipeline (for example, LigandMPNN) to the extent the input used to generate that output includes output from the AP Novo Generator. - "**Input**" means any data, biomolecular structures, atomic coordinates, catalytic motif specifications, residue constraints, ligand or substrate coordinates or chemical identifiers (such as CCD codes), or other conditioning information provided to or used with the AP Novo Generator. - **“Model Parameters**" means the trained AP Novo Generator model weights and parameters made available by Google to organizations (at its sole discretion) for their use in accordance with the [AP Novo Generator Model Parameters Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md) (not these Terms), together with (a) modifications to those weights and parameters, (b) works based on those weights and parameters, or (c) other code or machine learning models which incorporate, in full or in part, those weights and parameters. - **"Output"** means the generated 3D biomolecular structures, protein backbones, atomic coordinates, and initial amino acid sequences provided by the AP Novo Generator or using the Model Parameters, together with all ancillary and related generation metadata provided by the AP Novo Generator**,** as well as visual representations, descriptions, modifications, copies, or adaptations that are substantially derived from such output, including all Derived Output. For the avoidance of doubt, Output does not include your pre-existing Input in isolation, though any composite structure or file emitted by the AP Novo Generator that incorporates Input motif or ligand coordinates is governed as Output when Distributed as part of the generated design. ## Use Restrictions The AP Novo Generator belongs to us. Output is made available free of charge, for non-commercial use only, in accordance with the following use restrictions. You must not use nor allow others to use Output: 1. **On behalf of a commercial organization or in connection with any commercial activities, including research on behalf of commercial organizations.** 1. This means that only non-commercial organizations (*i.e.*, universities, non-profit organizations and research institutes, educational, journalism and government bodies) may use Output for their non-commercial activities. Output is not available for use by any other types of organization, even if conducting non-commercial work. 2. If you are a researcher affiliated with a non-commercial organization, provided **you are not a commercial organization or acting on behalf of a commercial organization**, you can use Output for your non-commercial affiliated research. 3. You must not share Output with any commercial organization. The only exception is making Output publicly available (including, indirectly, to commercial organizations) via a scientific publication or open source release or using these to support journalism, each of which is permitted. 2. **To misinform, misrepresent or mislead**, including: 1. providing false or inaccurate information in relation to your access to or use of Output; 2. misrepresenting your relationship with Google, including by using Google's trademarks, trade names, logos or suggesting endorsement by Google without Google's permission to do so (nothing in these Terms grants such permission); 3. misrepresenting the origin of Output in full or in part; 4. distributing misleading claims of expertise or capability, or engaging in the unauthorized or unlicensed practice of any profession, particularly in sensitive areas (*e.g.*, health, clinical medicine, or industrial safety); or 5. making decisions in domains that affect material or individual rights or well-being (*e.g.*, healthcare). 3. **To perform, promote or facilitate dangerous, illegal or malicious activities**, including: 1. **designing, generating, optimizing, or providing instructions for synthesizing or accessing biological toxins, venoms, virulence factors, regulated pathogens, chemical or biological weapons or their precursors, illegal or controlled substances, or hazardous metabolic disruptors;** 2. **bypassing, disabling, or attempting to circumvent biosecurity screening protocols, gene synthesis customer or sequence screening guidelines, or safety filters;** 3. abusing, harming, interfering, or disrupting any services, including generating or distributing content for deceptive or fraudulent activities or malware; 4. generating or distributing any content that infringes, misappropriates, or otherwise violates any individual's or entity's rights (including, but not limited to, rights in copyrighted content or third-party intellectual property); or 5. attempting to circumvent these Terms. 4. **To train, fine-tune, or create machine learning models or related technology for** ***de novo*** **protein or enzyme design, biomolecular structure generation, or protein sequence design similar to the AP Novo Generator as made available by Google ("Derived Models"),** including via distillation, synthetic data generation, or other methods. For the avoidance of doubt, the use restrictions set out in these Terms would apply in full to any Derived Models created in breach of these Terms. 5. **Without providing conspicuous notice that published or distributed Output is provided under and subject to these Terms and of any modifications you make to Output.** 1. This means if you remove, or cause to be removed (for example by using third-party software or format converters), these Terms, or any notice of these Terms, from Output, you must ensure further distribution or publication is accompanied by a copy of the [AP Novo Generator Output Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/OUTPUT_TERMS_OF_USE.md) and a "*Legally Binding Terms of Use*" text file that contains the following notice: "*By using this information, structure, or sequence, you agree to the AP Novo Generator Output Terms of Use found at* [*https://github.com/google-deepmind/alphaprotein-novo/blob/main/OUTPUT_TERMS_OF_USE.md*](https://github.com/google-deepmind/alphaprotein-novo/blob/main/OUTPUT_TERMS_OF_USE.md)*.* *To request access to the AP Novo Generator model parameters, follow the process set out at https://github.com/google-deepmind/alphaprotein-novo. You may only use these if received directly from Google. Use is subject to terms of use available at* [*https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md*](https://github.com/google-deepmind/alphaprotein-novo/blob/main/WEIGHTS_TERMS_OF_USE.md)*.*" 2. You must not include any additional or different terms that conflict with the [AP Novo Generator Output Terms of Use](https://github.com/google-deepmind/alphaprotein-novo/blob/main/OUTPUT_TERMS_OF_USE.md). 6. **Distribute Output, or disclose findings arising from using the AP Novo Generator or Output without citing our paper:** [Wu, Z et al. Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo*. bioRxiv (*2026*)* doi: 10.64898/2026.10.01.756017](https://www.biorxiv.org/content/10.64898/2026.10.01.756017v1). For the avoidance of doubt, this is an additional requirement to the notice requirements set out above. We grant you a non-exclusive, royalty-free, revocable, non-transferable and non-sublicensable (except as expressly permitted in these Terms) license to any intellectual property rights we have in Output to the extent necessary for these purposes. You agree that your right to use and share Output is subject to your compliance with these Terms. If you breach these Terms, Google reserves the right to request that you delete and cease use or sharing of Output in your possession or control and prohibit you from using the AP Novo Generator Assets (including the AP Novo Generator Model Parameters). You agree to immediately comply with any such request. ## Disclaimers Nothing in these Terms restricts any rights that cannot be restricted under applicable law or limits Google's responsibilities except as allowed by applicable law. **Output is provided on an "as is" basis, without warranties or conditions of any kind, either express or implied, including any warranties or conditions of title, non-infringement, merchantability, catalytic activity, stability, selectivity, or fitness for a particular purpose. You are solely responsible for determining the appropriateness of using, synthesizing, expressing, or distributing any of the Output and assume any and all risks associated with your use or distribution of any Output and your exercise of rights and obligations under these Terms. You and anyone you share Output with are solely responsible for these and their subsequent uses.** **Output consists of computational designs and predictions with varying levels of confidence and should be interpreted carefully. Use discretion before relying on, publishing, downloading, synthesizing, or otherwise using Output.** **Experimental Synthesis, Wet-Lab Expression, and Biocatalysis:** Outputs are computational designs whose physical, chemical, toxicologic, and biological properties have not been experimentally verified or safety-certified by Google. If you choose to physically synthesize nucleic acids, express proteins or enzymes, or perform chemical/biocatalytic reactions derived from Output in a laboratory setting, you do so solely at your own risk. You are solely responsible for: (a) conducting appropriate biosecurity and gene synthesis screening, (b) ensuring compliance with all applicable institutional biosafety (IBC), chemical safety, environmental, and regulatory standards, and (c) safely handling any reagents, substrates, catalytic intermediates, or reaction products. **Output is for non-commercial scientific research only. It is not intended, validated, or approved for clinical, diagnostic, or human therapeutic administration. You should not use Output for clinical purposes or rely on it for medical or other professional advice. Any content regarding those topics is provided for informational purposes only and is not a substitute for advice from a qualified professional.** ## Liabilities To the extent allowed by applicable law, you will indemnify Google and its directors, officers, employees, and contractors for any third-party legal proceedings (including actions by government authorities) arising out of or relating to your unlawful use of Output, physical synthesis or wet-lab use of Output, or violation of these Terms. This indemnity covers any liability or expense arising from claims, losses, damages, judgments, fines, litigation costs, and legal fees, except to the extent a liability or expense is caused by Google's breach, negligence, or willful misconduct. If you are legally exempt from certain responsibilities, including indemnification, then those responsibilities do not apply to you under these Terms. In no circumstances will Google be responsible for any indirect, special, incidental, exemplary, consequential, or punitive damages, or lost profits of any kind, even if Google has been advised of the possibility of such damages. Google's total, aggregate liability for all claims arising out of or in connection with these Terms or Output, including for its own negligence, is limited to $500. ## Governing Law and Disputes These Terms will be governed by the laws of the State of California. The state or federal courts of Santa Clara County, California shall have exclusive jurisdiction of any dispute arising out of these Terms. Given the nature of scientific research, it may take some time for any breach of these Terms to become apparent. To the extent allowed by applicable law, any legal claims relating to these Terms or Output can be initiated until the later of (a) the cut-off date under applicable law for bringing the legal claim; or (b) two years from the date you or Google (as applicable) became aware, or should reasonably have become aware, of the facts giving rise to that claim. You will not argue limitation, time bar, delay, waiver or the like in an attempt to bar an action filed within that time period, and neither will we. All rights not specifically and expressly granted to you by these Terms are reserved to Google. No delay, act or omission by Google in exercising any right or remedy will be deemed a waiver of any breach of these Terms and Google expressly reserves any and all rights and remedies available under these Terms or at law or in equity or otherwise, including the remedy of injunctive relief against any threatened or actual breach of these Terms without the necessity of proving actual damages. ## Miscellaneous Google may update these Terms (1) to reflect changes in how it does business, (2) for legal, regulatory, or biosecurity reasons, or (3) to prevent abuse or harm. The version of these Terms that was effective on the date the relevant Output was generated will apply to your use of that Output. If it turns out that a particular provision of these Terms is not valid or enforceable, this will not affect any other provisions.